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38,201 | Are patients with depression less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarction? | Patients with depression following an acute MI are less likely to adhere to recommended behavior and lifestyle changes intended to reduce the risk of subsequent cardiac events. This finding could explain why depression in the hospital is related to long-term prognosis in patients recovering from an MI. | WLS effectively treated severe obesity in 2 OI patients and substantially improved mobility and quality of life, theoretically reducing fracture risk. |
175,201 | Is laparoscopic anti-reflux surgery effective in obese patients with gastro-oesophageal reflux disease? | The outcome of laparoscopic anti-reflux surgery is similar between obese and non-obese patients with no trend towards a worse outcome in the obese or morbidly obese. Obesity should not be seen as a contra-indication, although it may be more technically challenging in this group of patients. Good results can be achieved in obese patients. | Slowing of muscle fiber conduction and decreased levels of circulating muscle proteins are sensitive markers of impaired muscle function, which are suitable for use in combination with clinical assessment and standard electrodiagnostic tests for accurate identification and follow-up of myopathic patients. |
67,832 | Is aging senescence : a short computer demonstration and implications for medical practice? | In this article, we debate that two popular explanations for the existence of senescence, namely, (1) the removal of elders for the benefit of the species and (2) the progressive deterioration of the organic machine due to continuous use, are not correct. While human populations continue to age, it is important that the physician understands that senescence, here defined as the progressive impairment of an organism, does not necessarily accompany aging, which we here define as the mere passage of time. As such, we argue that certain processes that were originally assumed to be part of aging should have their status changed because they are actually diseases. Physicians often encounter situations that depend on a better understanding of what limitations senescence imposes on most living species. The concepts of aging (the unavoidable passage of time), senescence (progressive physiologic impairment), and senility (the pathological development of diseases), are discussed. | The serum HGF concentration may be a useful variable for evaluating general condition and predicting perioperative surgical stress in sick children. |
198,764 | Does plasmodium chabaudi limit early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice? | P. c. chabaudi co-infection altered both local and lymph node Type 2 immune activation due to migration of N. brasiliensis larvae. Given recent work from other laboratories showing that N. brasiliensis-induced ChaFFs correlate to the extent of long-term lung damage, our results raise the possibility that co-infection with malaria might alter pulmonary repair processes following nematode migration. Further experimentation in the co-infection model developed here will reveal the longer-term consequences of the presence of both malaria and helminths in the lung. | These findings are highly consistent with our model of how auditory feedback is processed during speaking, where incoming feedback is compared with an efference-copy derived prediction of expected feedback. Thus, the results provide further insights about how speech motor output is controlled, as well as the computational role of auditory cortex in transforming auditory feedback. |
45,373 | Is dietary fiber intake associated with HbA1c level among prevalent patients with type 2 diabetes in Pudong New Area of Shanghai , China? | Dietary fiber may play an important role in reducing HbA1c level. Increasing fiber intake may be an effective approach to improve glycemic control among Chinese diabetic patients. | Untreated OSA hinders the response of exudative AMD to intravitreal bevacizumab. Treatment of OSA with continuous positive airway pressure therapy yields a subsequent anatomical response and functional improvement while requiring significantly less injections. Identifying and treating underlying OSA earlier in patients with exudative AMD may yield better functional outcomes. |
70,769 | Does iV chenodeoxycholate prevent calcium bilirubinate gallstones during total parenteral nutrition in the prairie dog? | IV CDC is effective in preventing TPN-associated gallstones in the prairie dog. | Smoking may suppress NO release in the uterine cervix in women with hrHPV infection. |
164,279 | Are neointimal hyperplasia and vascular endothelial growth factor expression increased in normoglycemic , insulin resistant , obese fatty rats? | In conclusion, insulin resistance increases neointimal hyperplasia and VEGF expression even with normoglycemia, after carotid angioplasty in rats. | In our experience, the topical use of tranexamic-acid after lung surgery reduces postoperative bleeding and blood transfusion volume. The topical administration of tranexamic-acid is safe without increasing the risk of post-operative complications related to pharmacological side-effects. |
11,838 | Is a structured implicit abstraction method to evaluate whether content of counseling before prostate cancer screening consistent with recommendations by experts? | Counseling varied but most transcripts included some expert-recommended facts. The absence of other facts could be a quality deficit or an effort to prioritize messages and lessen cognitive demands on the patient. | Many parameters of pigmented skin lesions evaluated by digital dermoscopy analysis are similar in the same patient and different from those belonging to different individuals. This indicates that, when considering a lesion, we should take into account the peculiar patient's characteristics. |
52,227 | Does long-term high-fat diet-induced obesity decrease the cardiac leptin receptor without apparent lipotoxicity? | The development of obesity via long-term feeding of a high-fat diet to rats does not result in cardiac lipotoxicity but promotes the down-regulation of OB-R. However, this does not result in altered levels of AMPK or ACC phosphorylations in this animal model. | Our study strongly suggests that supplementation of A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients. |
469 | Does miR-219-5p modulate cell growth of papillary thyroid carcinoma by targeting estrogen receptor α? | Our investigation identified miR-219-5p as a negative regulator of PTC development through targeting of ERα. | Our data confirmed the capability of N/OFQ to modulate the immune microenvironment in the lung of Th2-biased, OVA-sensitized Balb/c mice, suggesting N/OFQ-NOP axis as a novel pharmacological tool to modulate the inflammatory immune microenvironment in asthma. |
110,721 | Is clinical relevance of memory performance during Wada stimulus type dependent? | Verbal IAP stimuli show left hemispheric sensitivity in left language dominant MTLE patients. The dually encodable items of the IAP appear lesion sensitive. | Sleep apnea and obesity are independently associated with adverse LV remodeling and clinical outcomes in patients with preserved LV function, whereas continuous positive airway pressure therapy is associated with a beneficial effect on LV remodeling. Research investigating SA therapies in patients at high risk for LV remodeling and heart failure is warranted. |
210,508 | Does scopolamine improve autonomic balance in advanced congestive heart failure? | Transdermal scopolamine increases vagal activity as assessed by heart rate variability in patients with congestive heart failure. This autonomic modulation does not occur in all patients and can be predicted by RR interval changes. Whether such restoration of the autonomic balance might have beneficial effects in the long-term management of patients with congestive heart failure remains to be determined. | Echogenicity of carotid plaques is mainly determined by their elastin and calcium but not collagen or lipid content. In addition, echolucency is associated to higher elastin content. |
13,539 | Geriatric dentistry: is rethinking still required? | Complete edentulousness of both the arches was highest in the middle socio-economic group, and was the lowest in the low socio-economic group. Less than 50% of edentulous elderly and only 10% of partially edentulous elderly were wearing dentures. | Current management protocols place moderately differentiated T1 penile squamous carcinoma without vascular invasion in a low risk category for metastatic disease. As such, expectant management is currently offered as a primary option for these patients. Our experience suggests that patients in this category are in fact at higher risk for metastatic disease, and may be offered early groin dissection in place of expectant management. |
50,154 | Do site of disease and opportunistic infection predict survival in HIV-associated tuberculosis? | The site of culture-proven TB at presentation and the history of previous opportunistic infection are important predictors of survival in HIV-infected patients with TB. | These open-label data show trends toward normalization of EEG and concomitant clinical improvement using magnetic stimulation for PTSD. |
100,493 | Does mTHFR C677T variant reduce risk of sporadic Parkinson 's disease in ethnic Chinese? | We showed that the C677T polymorphism in MTHFR gene was associated with decreased PD susceptibility in a Han Chinese population from mainland China. Efforts to fully elucidate the pathophysiologic role of the variant in PD should be necessary. | In a large cohort of patients with Peyronie's disease the presence of sonographically detected sub-tunical calcifications during the initial office evaluation was independently associated with subsequent surgical intervention. |
188,024 | Is increased expression of GCNT1 associated with altered O-glycosylation of PSA , PAP , and MUC1 in human prostate cancers? | GCNT1 is over-expressed in prostate cancer and is associated with higher levels of core 2 O-sLe(x) in PSA, PAP and MUC1 proteins. Alterations of O-linked glycosylation could be important in prostate cancer biology and could provide a new avenue for development of prostate cancer specific glycoprotein biomarkers. | Although the prevalence of severe erosive esophagitis increases with age, the severity of heartburn is an unreliable indicator of the severity of erosive disease. More aggressive investigation and treatment may be necessary for elderly patients, regardless of the reported severity of heartburn. |
138,202 | Is shoulder pain a common problem following laparoscopic adjustable gastric band surgery? | Shoulder pain following LAGB surgery is common, usually affects the left shoulder, and can in some cases last 5 weeks or more. Avoiding injury to the crura during the procedure may prevent more prolonged pain. | Genistein can suppress obviously the bone resorption simulated by single IL-1beta. |
184,314 | Does ankle arthritis predict polyarticular disease course and unfavourable outcome in children with juvenile idiopathic arthritis? | In this Nordic population-based 8-year follow-up study, occurrence of ankle arthritis during the first year was associated with an unfavourable disease outcome. We suggest that ankle arthritis should be recognised in the assessment of prognosis and choice of treatment strategy in JIA. | Our results suggest that miRNA101 sustains the osteogenic differentiation of DFCs. |
79,558 | Does expression of 60-kD heat shock protein increase during carcinogenesis in the uterine exocervix? | The increasing degree of expression of HSP60 from L-SIL to carcinoma and the different intraepithelial distribution between L-SIL and H-SIL could be used as a new diagnostic tool. Moreover, HSP60 could have a role in cervical carcinogenesis. | [corrected] This observation is exceptional in many aspects: very early age of onset of extrapulmonary tuberculosis, no immune deficit, association with a rare congenital neurological syndrome. We discuss the possible link between this entity and the occurrence of tuberculosis. |
77,907 | Does wheelchair marathon create a systemic anti-inflammatory environment in persons with spinal cord injury? | The study demonstrated that half- and full-marathon wheelchair races increased plasma IL-6, but not TNF-α and hsCRP. Furthermore, the top athletes of the full-group had low plasma IL-6 and hsCRP at baseline. Wheelchair marathon competition, especially full-marathon, and daily training seem to have beneficial effects on SCI through the plasma IL-6 response. | Methylglyoxal-induced AGE accumulation impairs the activation of cell survival pathways during ischemia. Pyridoxamine-induced decrease of glycation inhibited the effects of MG accumulation in the heart, suggesting that it can be of added value to usual diabetic therapy. |
207,892 | Does ciprofloxacin reduce the stimulation of prostaglandin E ( 2 ) output by interleukin-1beta in human tendon-derived cells? | Ciprofloxacin reduces IL-1beta-induced PGE2 output in tendon-derived cells. The reduction in PGE2 output could modulate various cellular activities of IL-1beta, and may be implicated in fluoroquinolone-induced tendinopathy. | We found that a significant blood pressure rise during early upright positioning in patients with acute stroke was independently associated with a favorable outcome. No contraindication to early mobilization was found in this study. |
119,554 | Is aNLN a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer? | ANLN expression in breast cancer cells plays an important role during cell division and a high fraction of nuclear ANLN expression in tumor cells is correlated to poor prognosis in breast cancer patients, independent of Ki-67, tumor size, hormone receptor status, HER2 status, nodal status and age. | These results suggest that PKC(alpha) affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27(kip1). |
56,147 | Are maternal weight, eating and feeding practices associated with emotional eating in childhood? | The results highlight the relevance of maternal feeding behavior on emotional eating in childhood. In terms of preventing weight-related problems, the findings indicate the necessity of training parents in allowing their children more control and avoiding the restriction of food. | The low incidence of new contralateral vesicoureteral reflux diagnosed after subureteral polytetrafluoroethylene injection versus open ureteral reimplantation may be due to noninterference with the contralateral trigone in endoscopic correction. The risk of new contralateral reflux did not increase with reflux severity (grades IV and V), suggesting that the pop-off mechanism is unlikely to be the cause of contralateral reflux. |
21,077 | Does a candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibit stem-like characteristics of lung cancer stem-like cells? | FVTF inhibits the characteristics of LCSLCs through down-regulating expression of p-Akt. | DGE accelerates pancreatic anastomotic stricture development after PG in patients having soft pancreas with a pancreatic duct with a small diameter. Hence, to maintain the pancreatic duct patency, preventing DGE is important. |
57,153 | The deep inferior epigastric perforator flap for breast reconstruction: Is this the ideal flap for Asian women? | Breast reconstruction with DIEP flap is a safe and reliable method when used in Southeast Asian women, offering optimal results with less donor -site morbidity. Obesity increases the incidence of flap complication in this group of patients. | Skeletal muscle depletion is an independent prognostic factor. Intervention to prevent muscle wasting might be an effective strategy for improving the outcome of HCC. |
28,998 | Does immunosuppression with FTY720 and cyclosporine A inhibit rejection of adult porcine islet xenografts in rats? | Immunosuppression with FTY720 plus CsA inhibited almost all morphological signs of pig-to-rat islet xenograft rejection for up to 24 days after transplantation. Diabetic rats transplanted with APIs and immunosuppressed with FTY720 plus CsA remained normoglycemic for 53.0+/-15.8 days. | The clinical and biological behavior of three groups of the oral cavity tumors evaluated are similar. E-cadherin and β-catenin immunostaining showed no prognostic value for basaloid and conventional squamous cell carcinomas. |
189,965 | Is the goblet cell the cellular source of the anti-microbial angiogenin 4 in the large intestine post Trichuris muris infection? | The cellular source of mouse Ang4 in the colon following T. muris infection is the goblet cell and expression is under the control of IL-13. | Compared with patients of normal weight, overweight patients had a significantly higher risk of SSI after distal gastrectomy for cancer. |
206,376 | Does array-based DNA methylation profiling in male infertility reveal allele-specific DNA methylation in PIWIL1 and PIWIL2? | Our study identifies surrogate DNA methylation markers for idiopathic infertility in peripheral blood and suggests that allele-specific DNA methylation differences at regulatory sites of genes involved in piRNA regulation are associated with disturbed spermatogenesis. | An unhealed SLAP lesion did not preclude the successful outcome of concomitant rotator cuff repair. Therefore, repair of a concomitant SLAP lesion may not be an essential procedure for a successful outcome of a rotator cuff repair. |
95,823 | Do local sympathetic stimulation not only have local effects in patients with Raynaud 's phenomenon? | We found that statistically significant decrease of FVC values in patients with Primary RP compared to the healthy controls could be a impaired innervation of pulmonary system and a predictor of pulmonary vasospasm and/or pulmonary Raynaud's phenomenon, which may develop in future periods. | Despite the line-to-line variability of gene expression in the undifferentiated state of ES and iPS cells, the variance narrows significantly in lineage-specific iPS-derived cardiac progenitors, and these progenitor cells can be isolated and used for transplantation without generation of unwanted cell types. |
121 | Does capsular closure affect development of heterotopic ossification after hip arthroscopy? | Capsular closure did not seem to alter the rate of HO when compared with a control group of patients in whom the capsulotomy was not repaired. | Patients with prior CVD have five-year CVD risks approximately 20% higher, in absolute terms than patients without prior CVD, after accounting for standard risk factors. Almost half the CVD events occurred in those with prior CVD. These patients should be the highest priority for intensive preventive management in primary care. |
7,035 | Is increased drug resistance associated with reduced glucose levels and an enhanced glycolysis phenotype? | Hypoglycaemia increased resistance to cytotoxic agents, especially in tumour cells with a high dependence on glycolysis. Dual inhibition of the PI3K/mTOR pathway may be able to attenuate such hypoglycaemia-associated resistance. | Chiropractic Users appear no less likely to be vaccinated for influenza; whereas, younger Non-chiropractic CAM Users are more likely than Non-CAM Users to be vaccinated. |
145,754 | Does microRNA-21 act as an oncomir through multiple targets in human hepatocellular carcinoma? | MicroRNA-21 simultaneously regulates multiple programs that enhance cell proliferation, apoptosis or tumor invasiveness by targeting PTEN, PDCD4, and RECK in hepatocellular carcinomas. Targeting of microRNA-21 is sufficient to limit tumor cell proliferation and invasion in a manner that is likely to involve associated changes in multiple targets, suggesting that suppression of microRNA-21 may be a novel approach for the treatment of hepatocellular carcinoma. | These findings support the hypothesis that mast cells may play a role in the pathophysiology of haemorrhoids. Mast cells appear to participate equally in the early and later stages of these lesions. Mast cells are known to affect local vascular conditions through release of their chemical mediators and cytokines, and may influence haemorrhoid symptomatology and progression at this level. |
149,285 | Does etanercept treatment enhance clinical and neuroelectrophysiological recovery in partial spinal cord injury? | These results show that blocking TNF-α mediated inflammation pathway by an anti-TNF-α agent enhances clinical and electrophysiological recovery processes in partial SCI model. | This study suggests that EW-7197 exhibits potential as a treatment for liver fibrosis because it inhibits HIF1α-induced TGF-β signaling. |
50,974 | Is invasion of cytotrophoblastic ( JEG-3 ) cells up-regulated by interleukin-15 in vitro? | Trophoblast invasion and migration, but not proliferation, are enhanced by IL-15. Our results suggest a role for IL-15 in the modulation of MMP-1 secretion by JEG-3 cells. Furthermore, we speculate, that IL-15 might be related to the changes of cell adhesion molecule phenotype during the process of invasion. | This series indicates that the distal lip of a ruptured syringocele may function as a flap-valve, leading to anterior urethral obstruction. Advances in imaging and endoscopic instruments have altered the mode of presentation and management of this entity. |
112,954 | Does sphingosine-1-phosphate induce pro-remodelling response in airway smooth muscle cells? | S1P induces a steroid-resistant, pro-remodelling pathway in ASM cells. Targeting S1P or its receptors could be a novel treatment strategy for inhibiting airway remodelling in asthma. | Presence of hypertension and asymptomatic stroke are related with the severity of apathy and depression in Alzheimer's dementia. |
138,049 | Is aneuploidy involving chromosome 1 in failed-fertilized human oocytes unrelated to maternal age? | Aneuploidy involving chromosome 1 in failed-fertilized oocytes is unrelated to maternal age and occurs at a frequency similar to that for chromosomes 16, 18, and 21. | The results of this pilot clinical trial showed that intermittent high dose PPI enhance the antitumor effects of chemotherapy in MBC patients without evidence of additional toxicity, which requires urgent validation in a multicenter, randomized, phase III trial. |
17,182 | Sonographically measured perirenal fat thickness: an early predictor of atherosclerosis in HIV-1-infected patients receiving highly active antiretroviral therapy? | Our data demonstrated that PRFT measurement could be used as an early predictor of IMT increase in HIV-1-infected patients receiving highly active antiretroviral therapy. | SO-based LE may promote an excess of IL-6 production, especially in the T cell-dependent way of PBMC activation (via anti-CD3). OO emulsion seems to be immunologically more neutral than SO emulsion. |
19,259 | Is glycogen debranching enzyme associated with rat skeletal muscle sarcoplasmic reticulum? | These results confirm that similar to glycogen phosphorylase, glycogen debranching enzyme is associated with the skeletal muscle SR and is dissociated under exercise conditions. | Our study provides novel insights into the role of Pax8 in thyroid biology, exerted through transcriptional regulation of important genes involved in critical thyrocyte processes. In addition, we found new transcriptional partners of Pax8, which functionally cooperate with Pax8 in the regulation of thyroid gene transcription. Besides, our data demonstrate preferential location of Pax8 in non-promoter CpG regions. These data point to an orphan CpG island-mediated mechanism that represents a novel role of Pax8 in the transcriptional output of the thyrocyte. |
182,712 | Does routine Imaging for Diffuse Large B-Cell Lymphoma in First Complete Remission Improve Post-Treatment Survival : A Danish-Swedish Population-Based Study? | DLBCL relapse after first CR is infrequent, and the widespread use of routine imaging in Denmark did not translate into better survival. This favors follow-up without routine imaging and, more generally, a shift of focus from relapse detection to improved survivorship. | LDVP is effective in restoring urine output both in HRS and in CHF. This suggests that LDVP affects mechanisms not specifically related to liver disease. LDVP may be useful in critical patients with renal shutdown whilst awaiting liver or heart transplantation. |
139,417 | Is physical activity in young children reduced with increasing bronchial responsiveness? | Physical activity in preschool children was reduced with increasing bronchial responsiveness. The reduced physical activity was subclinical and not realized by parents or doctors despite daily diary cards and close clinical follow-up since birth. This observation warrants awareness of even very mild asthma symptoms in clinical practice. | This study showed that most patients with IH in The Netherlands were treated according to the main recommendations of the Dutch evidence-based guidelines. |
50,451 | Pneumonia following antipsychotic prescriptions in electronic health records: a patient safety concern? | The consistent pattern of an increased rate of chest infections after atypical antipsychotic prescriptions in older people seen in this outpatient study, together with the higher risk shown in a previous study on hospitalised patients, suggests a causal relationship. This is of importance since bronchopneumonia seems highly linked to fatal outcome. In the absence of a mechanism, further investigation of the role of antipsychotics in older people is needed. | Our data revealed that over-expression of HIF-1α and GLUT1 might play a role in the chemoresistance of AML. GLUT1 might be a potential target to reverse such drug resistance. |
9,531 | Does a Rho-kinase inhibitor improve cardiac function after 24-hour heart preservation? | Treatment with Rho-kinase inhibitor during allograft harvest and storage enhanced coronary blood flow and ventricular recovery through nitric oxide-dependent endothelial protection after reperfusion. Rho-kinase inhibitor could help prevent early myocardial dysfunction after transplantation. | Old Joe Camel cartoon advertisements are far more successful at marketing Camel cigarettes to children than to adults. This finding is consistent with tobacco industry documents that indicate that a major function of tobacco advertising is to promote and maintain tobacco addiction among children. |
152,764 | Does aTP induce c-fos expression in C6 glioma cells by activation of P ( 2Y ) receptors? | These studies demonstrate that ATP-induced c-fos mRNA expression is under multifactorial regulation. | Recent colonoscopy (within 36 months) is associated with a reduced incidence of CRC in patients with IBD, and lower mortality rates in those diagnosed with CRC. |
117,359 | Does basiliximab ( Simulect ) reduce acute rejection among sensitized kidney allograft recipients? | On the basis of appropriate selection of the donor and recipient, Simulect is effective and safety for the sensitized recipients as immunosuppressive induction therapy. | The phosphatidylcholine formula popularly used in subcutaneous injections for fat dissolution works primarily as a detergent causing nonspecific lysis of cell membranes. Our findings suggest that sodium deoxycholate is the major active component responsible for cell lysis. Detergent substances may have a role in eliminating unwanted adipose tissue. It is advised that physicians use caution until adequate safety data are available. |
44,379 | Does combined hypoxia inducible factor-1α and homogeneous endothelial progenitor cell therapy attenuate shunt flow-induced pulmonary arterial hypertension in rabbits? | Both the therapy with HIF-1α-transfected EPCs, and EPC transplantation, attenuated shunt flow-induced PAH, by means of an angiogenic effect. The former therapeutic method was more effective. | The limited disease specificity of FL-MOG-Abs identified using Alexa Fluor goat anti-human IgG (H + L) is due in part to detection of IgM-Abs. Use of the FL-MOG and restricting to IgG1-Abs substantially improves specificity for non-MS demyelinating diseases. |
144,289 | Is upper-normal waist circumference a risk marker for metabolic syndrome in normal-weight subjects? | Upper-normal WC represents a risk for acquiring a greater number of MetS components and the early stage of MetS components (prediabetes and borderline dyslipidemia), after adjusting for BMI, in a large general population with normal WC and BMI. | A risk stratification strategy for DXA scanning using a fracture risk assessment tool (FRAX) and a 10-year fracture risk threshold of 10% leads to a significant reduction in scan rates without compromising osteoporosis detection rates. |
53,339 | Is smoking linked to positive symptoms in acutely ill psychiatric patients? | In acutely ill psychiatric patients, smoking is linked with positive symptoms and not with negative symptoms. | As a social determinant of health, risk of food insecurity is a critical public health issue for low wage earners. While it is essential to increase the minimum wage in the short term, adequately addressing income adequacy in NS and elsewhere requires a shift in thinking from a focus on minimum wage towards more comprehensive policies ensuring an adequate livable income for everyone. |
110,252 | Is high frequency repetitive transcranial magnetic stimulation ( rTMS ) effective in migraine prophylaxis : an open labeled study? | High rate rTMS in left frontal cortex is effective and well tolerated for migraine prophylaxis. | The data demonstrate that diabetic kidneys have a reduced sensitivity to the anti-natriuretic action of elevated plasma aldosterone levels with no relative increase in ENaC subunit apical targeting, whereas there is increased expression of beta- and gamma-ENaC, which alone may play a role in the increased sodium reabsorption in the kidney in DM. |
182,086 | Is [ A reduced TKI dosage associated with loss of activity in EGFR mutated NSCLC patients ]? | Patients with EGFR mutated NSCLC and the need for TKI dose reduction seem to benefit in a similar manner from TKI therapy. | Although we previously showed substantial inhibition of target gene expression in DRG via intrathecal ssAAV9-shRNA administration, here we succeeded in inhibiting target gene expression in DRG neurons via intraperitoneal injection of ssAAV9-shRNA. AAV9-mediated delivery of shRNA will pave the way for creating animal models for investigating the molecular biology of the mechanisms of pain and sensory ganglionopathies. |
67,373 | Do detectable troponin levels predict poor prognosis in patients with left ventricular dysfunction undergoing internal defibrillator implantation? | In a cohort of patients with cardiomyopathy undergoing ICD implantation for standard clinical indications, presence of detectable TnT was associated with high mortality despite ICD implantation. TnT obtained before ICD implantation may be useful for risk stratification. | Long-term scarring, based on Vancouver scar assessments and histologic evaluation, was equivalent at 6 months in laser-ablated and sharply excised sites. Should this technology become practical, the potential clinical implications include a reduction in surgical blood loss without sacrifice of immediate engraftment rates or long-term outcome. |
22,040 | Do first trimester PAPP-A levels correlate with sFlt-1 levels longitudinally in pregnant women with and without preeclampsia? | Low first trimester PAPP-A levels suggests increased future risk of preeclampsia and correlate with serial sFlt-1 levels throughout pregnancy. Furthermore, low first trimester PAPP-A status significantly predicted decreased odds of normal pregnancy. | Our results showed that it was not only Bik but also Mcl-1 accumulation during the treatment of proteasome inhibitors, and combining proteasome inhibitors with Mcl-1 siRNA would enhance the ultimate anticancer effect suggesting this combination might be a more effective strategy for cancer therapy. |
39,448 | Does midazolam premedication reduce propofol requirements for sedation during regional anesthesia? | Midazolam premedication reduced propofol requirements and the incidence of intraoperative memory during sedation. These effects on sedation using propofol during spinal anesthesia are considered beneficial for patients. | Crude apple extract induces a higher paracellular resistance in differentiated Caco-2 cells. Future research will determine whether these results can be extrapolated to human small intestinal epithelia. |
12,472 | Is discharge home with drains after breast surgery producing satisfactory outcomes? | Overall patient satisfaction, hospital bed-days saved and low complication rates showed the efficacy of this early discharge policy. There were specific areas needing improvement. Patients should be more clearly informed of the early discharge plan. Greater attention should be paid to allaying patient anxiety during the first day at home, especially in older patients. | Elective LC for symptomatic cholelithiasis done by trainees under supervision does not increase surgical morbidity. |
13,984 | Does beta-Catenin mediate adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys? | These results show that beta-catenin in podocytes is dispensable for adult mice, but appears to be important in modulating the SD during ADR-induced perturbation of the filtration barrier. | In terms of patient safety, our data support a seven-day observation period for readmission rates when measuring or monitoring quality of care in emergency departments. |
103,558 | Does lower reoperation rates with the use of fibrin sealant versus tack for mesh fixation? | Fibrin sealant was superior to tacks for mesh fixation in laparoscopic groin hernia repair with regard to reoperation rates. The study could not differentiate between different hernia defect sizes, and future studies should therefore explore whether the superior effect of fibrin sealant applies for all hernia types and sizes. | Subjects with active CD have impaired oral iron absorption and elevated IL-6 levels compared with subjects with inactive disease. These findings suggest that oral iron may be of limited benefit to these patients. Future study is needed to define the molecular basis for impaired iron absorption. |
280 | Do adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction? | Adolescents with type 1 diabetes displayed evidence of endothelial dysfunction. Good metabolic control (glycated haemoglobin ≤7.5%, 58 mmol/mol) and regular physical activity of at least 4 h a week might be protective. | It has been recommended that a renal ultrasound scan be obtained in children 1 year after open ureteral reimplantation to rule out delayed obstruction. Our results suggest this is of low yield in patients with uncomplicated open ureteral reimplantation. |
147,653 | Does hypertrophic teres minor restore shoulder strength and range of external rotation in posterosuperior rotator cuff tears? | In patients with PS-RCT and atrophic ISP, shoulders with compensatory hypertrophy of the TM had greater strength and range of ER than shoulders with normal or atrophic TM. | Asthma control in real life is unsatisfactory. Rhinitis and asthma influence each other in terms of control and HRQoL. The control of rhinitis in asthma patients can lead to an optimization of HRQoL related to the upper airways, while this phenomenon is not so evident in asthma. These results suggest to strengthen the ARIA recommendation that asthma patients must be evaluated for rhinitis and vice versa. |
44,180 | Do both the concentration and redox state of glutathione and ascorbate influence the sensitivity of arabidopsis to cadmium? | Our observations indicate that GSH and AsA deficiency differentially alter plant GSH homeostasis, resulting in opposite Cd sensitivities relative to wild-type plants. Upon Cd exposure, GSH-deficient mutants were hampered in chelation. They experienced phenotypic disturbances and even more oxidative stress, and therefore activated multiple alternative pathways such as SOD, CAT and ascorbate peroxidase, indicating a higher Cd sensitivity. Ascorbate deficiency, however, was associated with enhanced PC synthesis in comparison with wild-type plants after Cd exposure, which contributed to decreased sensitivity towards Cd. | Our result indicates that the ROS production is not primarily increased in diabetic myotubes but rather is reduced. Moreover, the comparable ATP/H(2)O(2) ratios indicate that the reduced ROS production in diabetic myotubes parallels the reduced ATP production because ROS production in diabetic myotubes must be considered to be in a proportion comparable to lean. Thus, the increased ROS production seen in skeletal muscle of type 2 diabetic patients is an adaptation to the in vivo conditions. |
7,169 | Does [ GM6001 suppress scar formation after glaucoma filtration surgery in rabbits ]? | GM6001 can inhibit excessive proliferation of the fibroblasts in the filtering pathway to suppress scar tissue formation and prolong the existence of the functional filtration bleb in rabbits. | Laparoscopic adhesiolysis requires a specific skill set and may not be appropriate in all patients. Notwithstanding this, the laparoscopic approach demonstrates a benefit in 30-day morbidity and mortality even after controlling for preoperative patient characteristics. Given these findings in more than 9,000 patients and consistent rates of SBO requiring surgical intervention in the United States, increasing the use of laparoscopy could be a feasible way of to decrease costs and improving outcomes in this population. |
110,722 | Is propranolol effective in decreasing stress response due to airway manipulation and CO2 pneumoperitoneum in patients undergoing laparoscopic cholecystectomy? | Propranolol effectively blunts the stress response due to CO2 pneumoperitoneum during laparoscopic cholecystectomy. | Less-frequent urinary incontinence may be a powerful motivator for women to choose lifestyle modification to prevent diabetes. |
16,101 | Does patterns and correlate of tobacco use among suburban Philadelphia 6th- through 12th-grade students? | Cigarette experimentation and use begins as early as sixth grade and increases substantially by eighth grade. Our data suggest that efforts toward primary prevention of smoking should be pursued between sixth and eighth grade. | Administration of SR-T at a dosage 25% higher than the daily dosage of CT was safe. It ensured adequate tacrolimus levels in one-third of patients. Nevertheless, strict analytical surveillance is necessary during the initial months to allow dosage adjustments and to detect the minority of patients for whom SR-T does not achieve therapeutic tacrolimus levels. |
145,779 | Does modafinil improve functional outcomes in patients with residual excessive sleepiness associated with CPAP treatment? | In this secondary analysis of data from patients with OSA and excessive sleepiness despite CPAP use, modafinil was associated with improvements in patients' functional outcomes and their ability to engage in a broad array of everyday activities. | Although there may be a link between acetabular inclination angles and wear rates as reported by some authors, we found no differences in patient function or radiographic survivorship using alumina-on-alumina articulations. |
127,156 | Do quality scores predict discrepant statistical significances among meta-analyses on different targets of glycemic control in type 2 diabetes? | Physicians, researchers, and policy makers should bear in mind that common quality assessment instruments are necessary but not sufficient to guarantee reliable results and conclusions obtained from meta-analyses. | We report for the first time a benefit from upregulating compliant titin isoforms in a murine model with HFpEF-like symptoms. Constitutive and inducible RBM20 inhibition improves diastolic function resulting in greater tolerance to exercise. No effective therapies exists for treating this pervasive syndrome; therefore, our data on RBM20 inhibition are clinically significant. |
45,067 | Attitudes of community optometrists to smoking cessation: an untapped opportunity overlooked? | Despite low levels of current involvement, many optometrists were keen to receive training on smoking cessation topics. We suggest that there are untapped opportunities to develop brief interventions to promote smoking cessation services in community optometry settings. | Good prognosis in patients with overexpression of CD73 may be due to that overexpression of CD73 was more frequently observed in epithelial ovarian cancer patients with known good prognostic factors. Therefore, this result means that favorable differentiation and stage have more influence on survival outcome than adverse effect of CD73 per se. |
46,967 | Do dNA barcode libraries provide insight into continental patterns of avian diversification? | DNA barcodes can reveal continental patterns of diversification. Our analysis suggests that avian species are older in Argentina than in the Nearctic, supporting the idea that the greater diversity of the Neotropical avifauna is not caused by higher recent speciation rates. Species in the Palearctic also appear to be older than those in the Nearctic. These results, combined with the patterns of geographic structuring found in each region, suggest a major impact of Pleistocene glaciations in the Nearctic, a lesser effect in the Palearctic and a mild effect in the southern Neotropics. | Leukemia inhibitory factor might be one of the reasons that cause patients with salpingitis to be more susceptible to tubal pregnancy and might be involved in the implantation process of tubal pregnancy. |
167,772 | Is elevated preoperative hemoglobin A1c level associated with reduced long-term survival after coronary artery bypass surgery? | Poor preoperative glycemic control, as measured by an elevated HbA1c, is associated with reduced long-term survival after coronary artery bypass surgery. Optimizing glucose control in these patients may improve long-term survival. | In HIV patients, the presence of MAC, traditional risk factors and HIV viral load were independently associated with CAC. Presence of CAC and MAC may be useful in identifying HIV-infected individuals at higher risk for death. |
65,098 | Is poor social support associated with increases in depression but not anxiety over 2 years in heart failure outpatients? | Reducing psychological distress and increasing social support may improve health outcomes among HF outpatients. It is important for studies of HF to include assessment of depression, anxiety, and social support and evaluate their contributions to health outcomes. | In the absence of dietary surveillance, Absorbitol does not bring about improvement in weight, anthropometry, body composition, blood pressure or lipid profile. |
175,141 | Does paricalcitol counteract the increased contrast induced nephropathy caused by renin-angiotensin-aldosterone system blockade therapy in a rat model? | Our findings suggest that paricalcitol treatment counteracts increased contrast induced nephropathy caused by losartan. These findings warrant further clinical studies to investigate the benefit of paricalcitol in CIN prophylaxis. | Vascular permeability increase and cell influx are phenomena independent of gait disturbance. Neutrophils do not seem to contribute to development of gait disturbance in Zy arthritis. Sensitization of specific pain receptors in periarticular rather than in synovial tissue is responsible for gait disturbance in Zy-induced arthritis. |
37,343 | Is serum osteopontin , but not OPN gene polymorphism , associated with LVH in essential hypertensive patients? | Serum OPN is related to LVH incidence in essential hypertension subjects. OPN stimulates cardiomyocyte hypertrophy in vitro. OPN SNPs are not related to LVH incidence. | Cold pressor pain CS induces larger CPM effects than ischaemic pain CS. The larger CPM effect is, however, not associated with a larger blood pressure response. Other factors related to the CS should be investigated to understand why different CS modalities give different CPM effects. |
68,840 | Does intrapartum late deceleration develop more frequently in pre-eclamptic women with severe proteinuria? | In pre-eclampsia, the presence of severe proteinuria is associated with an increased likelihood of rLD. | These results suggest that higher CFTR expression is closely associated with cervical cancer progression, aggressive behaviors and poorer prognosis, indicating that CFTR may function as a novel tumor marker, a prospective prognostic indicator and a potential therapeutic target for cervical cancer. |
47,610 | Can UV radiation-blocking soft contact lenses attenuate UV radiation to safe levels during summer months in the southern United States? | The efficacy of the model used in this study was verified through direct comparison of the modeled and measured data. UV-blocking hydrogel soft contact lenses reduce the MED to the human eye and therefore limit the lifetime ocular dose. These lenses are highly recommended to prevent the development of UVR-related ocular pathologic conditions. | Both neutrophils and monocytes are differentiated from a common progenitor, a granulocyte macrophage colony forming cell, which can provide good explanation for the association between ANC and AMC nadirs. We would like to recommend physicians to observe the AMC nadir to predict the timing and severity of the ANC nadir. |
129,599 | Does plasticity in neuromagnetic cortical responses suggest enhanced auditory object representation? | The P2m amplitude increase and its persistence over time constitute a neuroplastic change. The P2m gain likely reflects enhanced object representation after stimulus experience and training, which enables listeners to improve their ability for scrutinizing fine differences in pre-voicing time. Different trajectories of brain and behaviour changes suggest that the preceding effect of a P2m increase relates to brain processes, which are necessary precursors of perceptual learning. Cautious discussion is required when interpreting the finding of a P2 amplitude increase between recordings before and after training and learning. | Obese children and adolescents developing IGT/T2D have a higher genetic predisposition than those who do not show these diseases, and this predisposition is mainly related to gene variants modulating the early phase of insulin secretion. Although these data are very interesting, they need to be replicated in other cohorts. |
158,592 | Does intravesical Bacillus Calmette-Guerin treatment improve patient survival in T1G3 bladder tumours? | In this study, BCG adjuvant immunotherapy was the only factor affecting recurrence, progression and survival. Conservative treatment using TUR followed by BCG may improve disease-specific survival. | Medical telephone counselling is a demanding task requiring competent specialists with dedicated training in communication supported by suitable computer technology. Provided these conditions are in place, computer-assisted telephone triage can be considered to be a safe method of assessing the potential clinical risks of patients' medical conditions. |
62,953 | Does interleukin-6 at discharge predict all-cause mortality in patients with sepsis? | Iinterleukin-6 at discharge is an independent predictor of all-cause mortality in patients with sepsis. Compared with IL-6 at admission, IL-6 at discharge better predicts all-cause mortality. | Administration of vasopressin during CPR resulted in significantly superior vital organ blood flow, but significantly decreased endogenous catecholamine plasma concentrations when compared with placebo. |
197,331 | Does coupled plasma filtration adsorption improve hemodynamics in septic shock? | Treatment with CPFA improves hemodynamic parameters in septic shock patients, ameliorating organ failure. | Signaling through both PDGF receptors is necessary for epicardial EMT and formation of epicardial-mesenchymal derivatives. PDGF receptors also have independent functions in the development of specific epicardial-derived cell fates. |
128,078 | Are distinct kinin-induced functions altered in circulating cells of young type 1 diabetic patients? | Our data point out alterations in kinin-mediated functions of circulating MNC from T1D patients, occurring before manifest macrovascular damage or progressed microvascular disease. Functional defects of MNC recruited to the vessel wall might compromise endothelial maintenance, initially without actively promoting endothelial damage, but rather by lacking supportive contribution to endothelial regeneration and healing. | The present study indicated that cigarette smoke could potentially modulate the expression of crucial molecules of NOD1 signal pathway and hBDs in human oral mucosal epithelium. NOD1 signal pathway could play an important role in the regulatory effects of CSE on hBDs levels in oral mucosal epithelial cells. |
47,251 | Trends in sociodemographic and health-related indicators in Bangladesh, 1993-2007: will inequities persist? | Persistent inequities in Bangladesh endanger equitable and sustainable human development in the country. Pro-poor development strategies based on the principles of equity and quality should be implemented to narrow existing gaps and further promote holistic and equitable human development. | LVHR is safe with a low incidence of perioperative complications. Patients with multiple, larger and recurrent hernias have longer operative times and LOS. This information can be used to guide preoperative planning for the patient, surgeon and treating institution. |
136,886 | Is a functional variant in microRNA-196a2 associated with susceptibility of colorectal cancer in a Chinese population? | The present study provides the first evidence that miR-196a2 polymorphism may contribute to CRC susceptibility in a Chinese population through modulating mature miR-196a expression. | Anti-S100A6 is a highly sensitive antibody for neurothekeomas, including CNT, and, in our experience, is superior in sensitivity to PGP9.5. However, like other antibodies used in evaluating neurothekeomas, S100A6 lacks specificity, as has been demonstrated in previous studies. Nevertheless, S100A6 can be useful in an immunohistochemical antibody panel to evaluate lesions where the differential diagnosis includes CNT. |
37,937 | Laparoscopic extraperitoneal aortic dissection: does single-port surgery offer the same possibilities as conventional laparoscopy? | The study results demonstrate the feasibility of single-port-access laparoscopy for extraperitoneal aortic lymphadenectomy. The lymph node count was similar to that described in the published experience of conventional laparoscopic extraperitoneal dissection. This preliminary report shows that SPS is usable for extraperitoneal aortic dissection and that it is possible to perform this procedure using only one skin incision compared with the three or four incisions required for conventional laparoscopy. | Among older persons with hip, clinical vertebral, or wrist/forearm fracture, although the risk for death was usually greater than the risk for a second fracture, both were high. The relatively low NNT to prevent 1 additional subsequent fracture fell within a range generally considered acceptable for secondary prevention strategies. |
5,950 | Does aquaporin-4 gene disruption in mice protect against impaired retinal function and cell death after ischemia? | AQP4 deletion in mice is neuroprotective in a transient ischemia model of retinal injury, suggesting the possible use of AQP4 inhibitors in retinal vascular occlusive and ischemic diseases. | The angle of gaze has a small but significant short-term effect on axial length, with greatest elongation occurring in inferonasal gaze. The elongation of the eye appears to be due to the influence of the extraocular muscles, in particular the oblique muscles. |
29,333 | Is lower expression of ER-α36 associated with the development of endometrial hyperplasia in PCOS patients? | Lower expression of ER-α66 is associated with the development of endometrial hyperplasia in PCOS patients. | Benign prostatic tissue was frequently found in margins of apex and bladder base, but uncommon in the anterior or posterior prostate. The presence of benign prostatic tissue at surgical margins had no prognostic relevance. |
59,808 | Is an interleukin-6 gene promoter polymorphism associated with polycystic ovary syndrome in South Indian women? | Our findings showed a significant statistical association between IL-6 -174 G/C SNP and PCOS risk in South Indian women. The 'G' allele frequency influences significantly higher in PCOS patients than controls. However, the exact mechanism by which 'G' allele frequency influence PCOS patients is yet to be determined. | Physical functional health-related quality of life measured as Short Form-36 predicts subsequent stroke risk independently of known risk factors in a general population. Poor physical functional health may indicate a high-risk population for stroke who may benefit most from targeted preventive interventions such as management of known risk factors. |
109,161 | Does toluene diisocyanate enhance human bronchial epithelial cells ' permeability partly through the vascular endothelial growth factor pathway? | TDI increases the permeability of HBE cell monolayers, partly through a VEGF-mediated pathway. This suggests the importance of VEGF in TDI-induced pulmonary diseases, but shows that other pathways may be involved in the pathogenic process. | Preserving freshly collected blood in 10% formalin is a reliable method to maintain cell morphology for manual counts for up to 1 month post collection. This is especially useful for field studies, where laboratory access is limited. Further evaluation is needed to determine the clinical usefulness of the manual RBC count in fish. |
172,304 | Does igE alone promote human lung mast cell survival through the autocrine production of IL-6? | These data taken together suggest that IgE in the absence of antigen promotes HLMC survival through the autocrine production of IL-6. This provides a further mechanism through which IL-6 and IgE contribute to the pathogenesis of asthma, and through which anti-IgE therapy might achieve its therapeutic effect. | Genetic variation at IL6R gene is associated with joint damage in RA. |
204,844 | Does concomitant gastroparesis negatively affect children with functional gallbladder disease? | Concomitant GP may occur in children with functional gallbladder disorders. Concomitant GP may negatively affect clinical outcome in children with BD. | Persistent hyperglycemia on serial glucose monitoring is an independent determinant of infarct expansion and is associated with worse functional outcome. There is an urgent need to study normalization of blood glucose after stroke. |
198,209 | Is staphylolysin an effective therapeutic agent for Staphylococcus aureus experimental keratitis? | Staphylolysin provided long-lasting protection against several strains of S. aureus, evident by both its strong anti-bacterial activity and beneficial histopathological results of treatment. | CNTF attenuated the gentamicin-elicited auditory impairment in guinea pigs. |
3,374 | Can We Predict Oral Antibiotic Treatment Failure in Children with Fast-Breathing Pneumonia Managed at the Community Level? | This study suggests that it may be difficult to create a pragmatic community-level prognostic child pneumonia tool based solely on clinical markers and pulse oximetry in an HIV and malaria endemic setting. Further work is needed to identify more accurate and reliable referral algorithms that remain feasible for use by community health workers. | Emergent colectomy in the setting of diverticulitis is associated with significantly higher morbidity, longer hospitalization, greater hospital charges, and a 9-fold increase in mortality. Prophylactic resection in the setting of recurrent diverticulitis should continue to be an acceptable and possibly more "conservative" approach. |
172,854 | Does catechol-o-methyltransferase gene polymorphism modify the effect of coffee intake on incidence of acute coronary events? | Heavy coffee consumption increases the incidence of acute coronary events in men with low but not high COMT activity. Further studies are required to determine to which extent circulating catecholamines mediate the relationship between coffee intake and CHD. | Results demonstrated the ability of FPP to preserve the integrity of liver against oxidative damage and protect hepatocytes against irreversible DNA structural modifications induced by MNU, highlighting its potential role as an immune-defense modulator during hepatocarcinoma. |
38,530 | Use of outpatient mental health services among children of different ages: are younger children more seriously ill? | Younger children showed very early use of multiple types of services for mental health problems and a pattern of persistent impairment despite long-standing use of services. These data argue strongly for focusing on emotional and behavioral issues among young children. | Analytic morphomics may be used to help assess NODAT risk in patients undergoing liver transplantation. |
179,893 | Are par-3 partitioning defective 3 homolog ( C. elegans ) and androgen-induced prostate proliferative shutoff associated protein genes mutationally inactivated in prostate cancer cells? | The mutational inactivation in a prostate cancer cell line of the PARD3 gene involved in asymmetric cell division and maintenance of cell-polarity suggests that the loss of cell-polarity contributes to prostate carcinogenesis. | Although our overall failure rate was greater than anticipated, the relatively low serum ion levels and no revisions for pseudotumors in young male patients up to 10 years postoperatively provide some evidence of the suitability of hip resurfacing in this subgroup. |
268 | Does noble-Collip Drum Trauma induce Disseminated Intravascular Coagulation But Not Acute Coagulopathy of Trauma-Shock? | The systemic thrombin generation accelerated by insufficient antithrombin control leads to the consumption of platelets and coagulation factors associated with hyperfibrin(ogen)olysis. These changes are collectively termed disseminated intravascular coagulation with the fibrinolytic phenotype. | Abrogation of the G2 checkpoint should be an effective strategy against p53-deficient leukemia cells to irradiation-induced cell killing. |
15,518 | Does an obese prepregnancy body mass index influence outcome in pregnancies complicated by mild gestational hypertension remote from term? | In patients with mild gestational hypertension remote from term, an obese prepregnancy BMI was associated with similar rates of progression to preeclampsia. Secondarily, an obese prepregnancy BMI was associated with higher birth weights and an increased incidence of cesarean delivery. | Factors associated with MHS use differ according to adult development stages. Programmes and policies should be based on age-related contextualisation to increase MHS use. |
37,639 | Is postinduction positron emission tomography assessment of N2 nodes associated with ypN2 disease or overall survival in stage IIIA non-small cell lung cancer? | Postinduction PET avidity for N2 nodes is not associated with ypN2 disease, overall survival, or disease-free survival in patients undergoing induction chemotherapy for stage IIIA/pN2 disease. | Our results suggest that chronic administration of mitragynine can altered the cognitive behavioral function in mice. |
27,530 | Do age and distal colonic findings determine the yield of advanced proximal neoplasia in Chinese patients with rectal bleeding? | Colonoscopy should be considered for Chinese patients with rectal bleeding who are aged > or =35 years or those aged <35 years who have adenoma in the distal colon. | DM is common in patients with hyperglycemia after trauma. As opposed to DH, SIH is associated with higher mortality after trauma. Further research is warranted to identify mechanisms causing hyperglycemia and subsequent worse outcomes after trauma. |
181,949 | Does a Chinese medicine formula Gegen Qinlian decoction suppress expansion of human renal carcinoma with inhibition of matrix metalloproteinase-2? | The findings of this study provide experimental evidence of the inhibition of expansion and neoangiogenesis of renal carcinoma by Chinese medicine formula GQLD with involvement of MMP-2 suppression. | IL-18 and IL-12 can synergistically enhance cytotoxic functions of TILs from human gastric cancer. |
205,448 | Does baseline Ability make a Larger Contribution to Race Performance in High-School Sprinters Than Race Experience or Training Exposure? | Although race experience and training exposure impact high-school sprinters' performance, baseline ability is the dominant influence. | The measurement of caspase-cleaved and uncleaved cytokeratin-18 appears to be an early predictor for survival in severe septic patients with hepatic dysfunction. Furthermore, the loss of parenchymal cells due to necrosis may be the primary mode of cell death in these patients. This may limit possible therapeutic options. |
12,306 | Does use of enoxaparin result in more haemorrhagic complications after breast surgery than unfractionated heparin? | LMWH thromboprophylaxis was associated with a significant increase in haemorrhagic complications after breast surgery compared with UFH. | Trendelenburg positioning and/or repositioning the heart during cardiac surgery may induce acute reperfusion injury and increase ROS. |
185,875 | Is plasma lipoprotein-associated phospholipase A2 inversely correlated with proprotein convertase subtilisin-kexin type 9? | Despite increasing effects on LDL cholesterol, higher PCSK9 levels are unlikely to confer impaired Lp-PLA(2) metabolism. We propose to evaluate the possible influence of PCSK9 inhibiting strategies on Lp-PLA(2) regulation and vice versa to determine effects of Lp-PLA(2) inhibitors on the PCSK9 pathway. | In MTC patients, extrathyroidal extension and stage at diagnosis are the only independent predictors of (recurrence-free) life expectancy. Patients diagnosed in an early stage of disease and patients without detectable recurrence have favourable life expectancy independently of biochemical cure. |
47,833 | Is hepatic Met-enkephalin immunoreactivity enhanced in primary biliary cirrhosis? | These results suggest that the human liver in cholestasis may be a source of endogenous opioids. | The SWE elasticity indices of malignant thyroid nodules were significantly high. Adding SWE to conventional US did not improve diagnostic performance. |
151,217 | Does subject body mass index affect Doppler waveform in celiac artery by duplex ultrasound? | Subjects with higher BMI showed reduced PSV due to a larger CA diameter and probably due to more fatty tissue accumulation around the CA origin. | Trastuzumab plus docetaxel is an active and well-tolerated regimen in women with HER-2 3+ overexpressing or FISH-positive metastatic breast cancer. |
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