tokens
sequence | folded_tokens
sequence | tags
sequence | labels
sequence |
---|---|---|---|
[
"Electrophoretic",
"mobility",
"shift",
"assays",
"and",
"competition",
"experiments",
"showed",
"that",
"site",
"A",
"is",
"recognized",
"by",
"an",
"NF1",
"protein",
"."
] | [
"electrophoretic",
"mobility",
"shift",
"assay",
"and",
"competition",
"experiment",
"show",
"that",
"site",
"a",
"be",
"recognize",
"by",
"a",
"nf1",
"protein",
"."
] | [
8,
7,
7,
35,
30,
7,
35,
21,
20,
7,
7,
9,
28,
20,
2,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
[
"Examination",
"of",
"the",
"MMP-2",
"RE1",
"sequence",
"revealed",
"an",
"incomplete",
"Y-box",
"sequence",
"(",
"CTGCTGGGCAAG",
")",
",",
"which",
"specifically",
"interacted",
"with",
"recombinant",
"YB-1",
"on",
"DMS",
"protection",
"footprinting",
"analysis",
"."
] | [
"examination",
"of",
"the",
"mmp-2",
"re1",
"sequence",
"reveal",
"a",
"incomplete",
"y-box",
"sequence",
"(",
"ctgctgggcaag",
")",
",",
"which",
"specifically",
"interact",
"with",
"recombinant",
"yb-1",
"on",
"dm",
"protection",
"footprinting",
"analysis",
"."
] | [
7,
20,
2,
7,
7,
7,
21,
2,
8,
7,
7,
7,
7,
39,
16,
33,
26,
21,
20,
8,
7,
20,
7,
7,
7,
7,
15
] | [
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2
] |
[
"Hence",
",",
"scs32",
"only",
"partially",
"suppressed",
"the",
"ts",
"phenotype",
"and",
"was",
"unable",
"to",
"suppress",
"the",
"Ino-phenotype",
"of",
"rpo26-31",
"."
] | [
"hence",
",",
"scs32",
"only",
"partially",
"suppress",
"the",
"t",
"phenotype",
"and",
"be",
"unable",
"to",
"suppress",
"the",
"ino-phenotype",
"of",
"rpo26-31",
"."
] | [
26,
16,
7,
26,
26,
21,
2,
35,
7,
30,
21,
8,
24,
22,
2,
7,
20,
7,
15
] | [
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2
] |
[
"In",
"contrast",
",",
"both",
"Sp1",
"and",
"ETS",
"proteins",
"are",
"required",
"to",
"bring",
"about",
"full",
"promoter",
"activity",
"in",
"the",
"Surf-1",
"direction",
"."
] | [
"in",
"contrast",
",",
"both",
"sp1",
"and",
"et",
"protein",
"be",
"require",
"to",
"bring",
"about",
"full",
"promoter",
"activity",
"in",
"the",
"surf-1",
"direction",
"."
] | [
20,
7,
16,
30,
7,
30,
7,
35,
10,
28,
24,
22,
26,
8,
7,
7,
20,
2,
7,
7,
15
] | [
2,
2,
2,
2,
0,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2
] |
[
"We",
"have",
"subcloned",
"into",
"pBR322",
"deoxyribonucleic",
"acid",
"(",
"DNA",
")",
"sequences",
"mapping",
"either",
"in",
"the",
"coding",
"region",
",",
"the",
"5",
"'",
"spacer",
",",
"or",
"the",
"3",
"'",
"spacer",
"of",
"the",
"H2B",
"histone",
"gene",
"."
] | [
"we",
"have",
"subclon",
"into",
"pbr322",
"deoxyribonucleic",
"acid",
"(",
"dna",
")",
"sequence",
"map",
"either",
"in",
"the",
"code",
"region",
",",
"the",
"5",
"'",
"spacer",
",",
"or",
"the",
"3",
"'",
"spacer",
"of",
"the",
"h2b",
"histone",
"gene",
"."
] | [
18,
10,
28,
20,
7,
8,
7,
7,
7,
7,
35,
14,
30,
20,
2,
14,
7,
16,
2,
39,
3,
7,
16,
30,
2,
39,
3,
7,
20,
2,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2
] |
[
"The",
"combination",
"of",
"hydralazine",
"hydrochloride",
"and",
"isosorbide",
"dinitrate",
"also",
"improves",
"survival",
",",
"but",
"direct",
"comparison",
"of",
"both",
"regimens",
"provided",
"evidence",
"for",
"a",
"less",
"favourable",
"effect",
"than",
"that",
"of",
"the",
"ACE",
"inhibitors",
"."
] | [
"the",
"combination",
"of",
"hydralazine",
"hydrochloride",
"and",
"isosorbide",
"dinitrate",
"also",
"improve",
"survival",
",",
"but",
"direct",
"comparison",
"of",
"both",
"regimen",
"provide",
"evidence",
"for",
"a",
"less",
"favourable",
"effect",
"than",
"that",
"of",
"the",
"ace",
"inhibitor",
"."
] | [
2,
7,
20,
7,
7,
30,
7,
7,
26,
9,
7,
16,
30,
8,
7,
20,
2,
35,
21,
7,
20,
2,
41,
8,
7,
20,
2,
20,
2,
7,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2
] |
[
"To",
"address",
"mechanisms",
"that",
"define",
"interactions",
"of",
"Site",
"II",
"regulatory",
"factors",
"with",
"this",
"cell",
"cycle",
"control",
"element",
",",
"we",
"have",
"investigated",
"these",
"determinants",
"of",
"transcriptional",
"regulation",
"at",
"the",
"G1",
"/",
"S",
"phase",
"transition",
"in",
"FDC-P1",
"hematopoietic",
"progenitor",
"cells",
"."
] | [
"to",
"address",
"mechanism",
"that",
"define",
"interaction",
"of",
"site",
"ii",
"regulatory",
"factor",
"with",
"this",
"cell",
"cycle",
"control",
"element",
",",
"we",
"have",
"investigate",
"these",
"determinant",
"of",
"transcriptional",
"regulation",
"at",
"the",
"g1",
"/",
"s",
"phase",
"transition",
"in",
"fdc-p1",
"hematopoietic",
"progenitor",
"cell",
"."
] | [
24,
22,
35,
33,
10,
35,
20,
7,
39,
8,
35,
20,
2,
7,
7,
7,
7,
16,
18,
10,
28,
2,
35,
20,
8,
7,
20,
2,
7,
40,
7,
7,
7,
20,
7,
8,
7,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"goal",
"of",
"this",
"study",
"was",
"to",
"identify",
"neuronal",
"cell",
"cultures",
"that",
"express",
"RC3",
"/",
"neurogranin",
",",
"to",
"check",
"whether",
"they",
"are",
"sensitive",
"to",
"T3",
",",
"and",
"to",
"examine",
"the",
"mechanism",
"of",
"regulation",
"."
] | [
"the",
"goal",
"of",
"this",
"study",
"be",
"to",
"identify",
"neuronal",
"cell",
"culture",
"that",
"express",
"rc3",
"/",
"neurogranin",
",",
"to",
"check",
"whether",
"they",
"be",
"sensitive",
"to",
"t3",
",",
"and",
"to",
"examine",
"the",
"mechanism",
"of",
"regulation",
"."
] | [
2,
7,
20,
2,
7,
21,
24,
22,
8,
7,
35,
33,
10,
7,
40,
7,
16,
24,
22,
20,
18,
10,
8,
24,
7,
16,
30,
24,
22,
2,
7,
20,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Although",
"previous",
"data",
"have",
"suggested",
"that",
"Rev",
"uses",
"the",
"same",
"export",
"pathway",
"as",
"uracil",
"rich",
"small",
"nuclear",
"RNAs",
"and",
"5S",
"ribosomal",
"RNA",
",",
"the",
"CTE",
"seems",
"to",
"interact",
"with",
"evolutionarily",
"conserved",
"factors",
"that",
"are",
"essential",
"for",
"cellular",
"mRNA",
"export",
"."
] | [
"although",
"previous",
"datum",
"have",
"suggest",
"that",
"rev",
"use",
"the",
"same",
"export",
"pathway",
"as",
"uracil",
"rich",
"small",
"nuclear",
"rna",
"and",
"5",
"ribosomal",
"rna",
",",
"the",
"CTE",
"seem",
"to",
"interact",
"with",
"evolutionarily",
"conserve",
"factor",
"that",
"be",
"essential",
"for",
"cellular",
"mrna",
"export",
"."
] | [
20,
8,
35,
10,
28,
20,
7,
9,
2,
8,
7,
7,
20,
7,
8,
8,
8,
35,
30,
7,
8,
7,
16,
2,
36,
9,
24,
22,
20,
26,
28,
35,
33,
10,
8,
20,
8,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Human",
"Duo",
"contains",
"a",
"guanine",
"nucleotide",
"exchange",
"factor",
"(",
"GEF",
")",
"domain",
"that",
"is",
"likely",
"to",
"be",
"rac1",
"specific",
",",
"a",
"pleckstrin",
"homology",
"(",
"PH",
")",
"domain",
"and",
"spectrin",
"like",
"repeat",
"units",
"."
] | [
"human",
"duo",
"contain",
"a",
"guanine",
"nucleotide",
"exchange",
"factor",
"(",
"gef",
")",
"domain",
"that",
"be",
"likely",
"to",
"be",
"rac1",
"specific",
",",
"a",
"pleckstrin",
"homology",
"(",
"ph",
")",
"domain",
"and",
"spectrin",
"like",
"repeat",
"unit",
"."
] | [
8,
7,
9,
2,
7,
7,
7,
7,
39,
7,
7,
7,
33,
9,
8,
24,
22,
7,
8,
16,
2,
7,
7,
39,
7,
7,
7,
30,
7,
20,
7,
35,
15
] | [
0,
1,
2,
2,
0,
1,
1,
1,
2,
0,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
0,
1,
2,
0,
2,
2,
2,
0,
1,
1,
1,
2
] |
[
"S2F",
",",
"a",
"leaf",
"specific",
"trans",
"acting",
"factor",
",",
"binds",
"to",
"a",
"novel",
"cis",
"acting",
"element",
"and",
"differentially",
"activates",
"the",
"RPL21",
"gene",
"."
] | [
"s2f",
",",
"a",
"leaf",
"specific",
"trans",
"acting",
"factor",
",",
"bind",
"to",
"a",
"novel",
"ci",
"act",
"element",
"and",
"differentially",
"activate",
"the",
"rpl21",
"gene",
"."
] | [
7,
16,
2,
7,
8,
8,
8,
7,
16,
9,
24,
2,
8,
7,
14,
7,
30,
26,
9,
2,
7,
7,
15
] | [
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
[
"ArgR",
"was",
"shown",
"to",
"be",
"a",
"dimer",
"of",
"two",
"equal",
"subunits",
",",
"each",
"with",
"a",
"molecular",
"mass",
"of",
"37,000",
"Da",
"."
] | [
"argr",
"be",
"show",
"to",
"be",
"a",
"dimer",
"of",
"two",
"equal",
"subunit",
",",
"each",
"with",
"a",
"molecular",
"mass",
"of",
"37,000",
"da",
"."
] | [
7,
21,
28,
24,
22,
2,
7,
20,
39,
8,
35,
16,
2,
20,
2,
8,
7,
20,
39,
7,
15
] | [
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Plasma",
"leptin",
"concentrations",
"were",
"higher",
"in",
"women",
"than",
"men",
",",
"even",
"after",
"the",
"adjustment",
"for",
"differences",
"in",
"fat",
"mass",
"(",
"28",
"+",
"/-",
"3",
"ng",
"/",
"ml",
"for",
"women",
"vs."
] | [
"plasma",
"leptin",
"concentration",
"be",
"higher",
"in",
"woman",
"than",
"man",
",",
"even",
"after",
"the",
"adjustment",
"for",
"difference",
"in",
"fat",
"mass",
"(",
"28",
"+",
"/-",
"3",
"ng",
"/",
"ml",
"for",
"woman",
"vs."
] | [
7,
7,
35,
21,
41,
20,
35,
20,
35,
16,
26,
20,
2,
7,
20,
35,
20,
8,
7,
7,
39,
30,
39,
39,
7,
40,
7,
20,
35,
30
] | [
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Consistent",
"with",
"effects",
"on",
"STAT",
"activation",
",",
"altered",
"SHP-1",
"expression",
"also",
"affected",
"EGF",
"induced",
"activation",
"of",
"the",
"mitogen",
"activated",
"protein",
"kinase",
"pathway",
";",
"expression",
"of",
"SHP-1",
"-",
"(",
"Cys",
"--",
">",
"Ser",
")",
"inhibited",
"activity",
"of",
"MEK",
"by",
"approximately",
"25",
"%",
",",
"whereas",
"expression",
"of",
"SHP-1",
"resulted",
"in",
"a",
"approximately",
"25",
"%",
"increase",
"."
] | [
"consistent",
"with",
"effect",
"on",
"stat",
"activation",
",",
"altered",
"shp-1",
"expression",
"also",
"affect",
"egf",
"induced",
"activation",
"of",
"the",
"mitogen",
"activate",
"protein",
"kinase",
"pathway",
";",
"expression",
"of",
"shp-1",
"-",
"(",
"cy",
"--",
">",
"ser",
")",
"inhibit",
"activity",
"of",
"mek",
"by",
"approximately",
"25",
"%",
",",
"whereas",
"expression",
"of",
"shp-1",
"result",
"in",
"a",
"approximately",
"25",
"%",
"increase",
"."
] | [
8,
20,
35,
20,
7,
7,
16,
8,
7,
7,
26,
21,
7,
8,
7,
20,
2,
7,
28,
7,
7,
7,
40,
7,
20,
7,
40,
39,
7,
40,
41,
7,
39,
21,
7,
20,
7,
20,
26,
39,
7,
16,
20,
7,
20,
7,
21,
20,
2,
26,
39,
7,
7,
15
] | [
2,
2,
2,
2,
0,
2,
2,
2,
0,
2,
2,
2,
0,
2,
2,
2,
2,
0,
1,
1,
1,
2,
2,
2,
2,
0,
1,
1,
1,
1,
1,
1,
1,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"This",
"interaction",
"involved",
"the",
"SH3",
"region",
"of",
"p50",
"(",
"csk",
")",
"and",
"a",
"proline",
"rich",
"region",
"(",
"PPPLPERTPESFVLADM",
")",
"outside",
"the",
"catalytic",
"region",
"of",
"PTP-PEST",
"."
] | [
"this",
"interaction",
"involve",
"the",
"sh3",
"region",
"of",
"p50",
"(",
"csk",
")",
"and",
"a",
"proline",
"rich",
"region",
"(",
"PPPLPERTPESFVLADM",
")",
"outside",
"the",
"catalytic",
"region",
"of",
"ptp-pest",
"."
] | [
2,
7,
21,
2,
7,
7,
20,
7,
39,
7,
7,
30,
2,
7,
8,
7,
39,
36,
39,
20,
2,
8,
7,
20,
7,
15
] | [
2,
2,
2,
2,
0,
1,
2,
0,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2
] |
[
"Following",
"2.5",
"Gy",
",",
"HbO2",
"changes",
"were",
"minimal",
"."
] | [
"follow",
"2.5",
"gy",
",",
"hbo2",
"change",
"be",
"minimal",
"."
] | [
14,
39,
7,
16,
7,
35,
21,
8,
15
] | [
2,
2,
2,
2,
0,
2,
2,
2,
2
] |
[
"Polarised",
"expression",
"of",
"human",
"intestinal",
"N-benzoyl-L-tyrosyl-p-aminobenzoic",
"acid",
"hydrolase",
"(",
"human",
"meprin",
")",
"alpha",
"and",
"beta",
"subunits",
"in",
"Madin-Darby",
"canine",
"kidney",
"cells",
"."
] | [
"polarise",
"expression",
"of",
"human",
"intestinal",
"n-benzoyl-l-tyrosyl-p-aminobenzoic",
"acid",
"hydrolase",
"(",
"human",
"meprin",
")",
"alpha",
"and",
"beta",
"subunit",
"in",
"madin-darby",
"canine",
"kidney",
"cell",
"."
] | [
28,
7,
20,
8,
8,
8,
7,
7,
39,
8,
7,
7,
7,
30,
7,
35,
20,
8,
8,
7,
35,
15
] | [
2,
2,
2,
2,
2,
0,
1,
1,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Neither",
"mutant",
"exhibited",
"derepression",
"of",
"the",
"silent",
"mating",
"type",
"loci",
"."
] | [
"neither",
"mutant",
"exhibit",
"derepression",
"of",
"the",
"silent",
"mating",
"type",
"locus",
"."
] | [
2,
8,
21,
7,
20,
2,
8,
7,
7,
35,
15
] | [
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2
] |
[
"We",
"established",
"that",
"the",
"2.6",
"kb",
"mRNA",
"V-1",
"and",
"the",
"2.3",
"kb",
"GGT",
"mRNA",
"V-2",
"derive",
",",
"by",
"alternate",
"splicing",
",",
"from",
"a",
"primary",
"transcript",
"initiated",
"on",
"a",
"distal",
"promoter",
"on",
"the",
"rat",
"GGT",
"gene",
"."
] | [
"we",
"establish",
"that",
"the",
"2.6",
"kb",
"mrna",
"v-1",
"and",
"the",
"2.3",
"kb",
"GGT",
"mrna",
"v-2",
"derive",
",",
"by",
"alternate",
"splicing",
",",
"from",
"a",
"primary",
"transcript",
"initiate",
"on",
"a",
"distal",
"promoter",
"on",
"the",
"rat",
"GGT",
"gene",
"."
] | [
18,
21,
20,
2,
39,
7,
7,
7,
30,
2,
39,
7,
36,
7,
7,
10,
16,
20,
8,
7,
16,
20,
2,
8,
7,
28,
20,
2,
8,
7,
20,
2,
7,
36,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2
] |
[
"A",
"specific",
"distal",
"promoter",
"controls",
"gamma-glutamyl",
"transpeptidase",
"gene",
"expression",
"in",
"undifferentiated",
"rat",
"transformed",
"liver",
"cells",
"."
] | [
"a",
"specific",
"distal",
"promoter",
"control",
"gamma-glutamyl",
"transpeptidase",
"gene",
"expression",
"in",
"undifferentiated",
"rat",
"transform",
"liver",
"cell",
"."
] | [
2,
8,
8,
7,
9,
7,
7,
7,
7,
20,
8,
7,
28,
7,
35,
15
] | [
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"These",
"repressor",
"sites",
"are",
"pyrimidine",
"rich",
"and",
"bind",
"avidly",
"to",
"the",
"polypyrimidine",
"tract",
"binding",
"protein",
"(",
"PTB",
")",
"in",
"HeLa",
"nuclear",
"extracts",
"as",
"determined",
"by",
"UV",
"crosslinking",
"/",
"competition",
"assays",
"."
] | [
"these",
"repressor",
"site",
"be",
"pyrimidine",
"rich",
"and",
"bind",
"avidly",
"to",
"the",
"polypyrimidine",
"tract",
"binding",
"protein",
"(",
"ptb",
")",
"in",
"helum",
"nuclear",
"extract",
"as",
"determine",
"by",
"uv",
"crosslinking",
"/",
"competition",
"assay",
"."
] | [
2,
7,
35,
10,
7,
8,
30,
10,
26,
24,
2,
7,
7,
7,
7,
39,
7,
7,
20,
7,
8,
35,
20,
28,
20,
7,
7,
40,
7,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"For",
"higher",
"expression",
"of",
"lipA",
"in",
"S.",
"lividans",
",",
"the",
"gene",
"was",
"cloned",
"next",
"to",
"the",
"strong",
"aphII",
"promoter",
"."
] | [
"for",
"higher",
"expression",
"of",
"lipa",
"in",
"S.",
"lividan",
",",
"the",
"gene",
"be",
"clone",
"next",
"to",
"the",
"strong",
"aphius",
"promoter",
"."
] | [
20,
41,
7,
20,
7,
20,
36,
35,
16,
2,
7,
21,
28,
8,
24,
2,
8,
7,
7,
15
] | [
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
[
"Within",
"a",
"135-bp",
"core",
"homology",
"region",
",",
"the",
"human",
"HS12",
"enhancers",
"are",
"approximately",
"90",
"%",
"identical",
"to",
"the",
"murine",
"homolog",
"and",
"include",
"several",
"motifs",
"previously",
"demonstrated",
"to",
"be",
"important",
"for",
"function",
"of",
"the",
"murine",
"enhancer",
";",
"additional",
"segments",
"of",
"high",
"sequence",
"conservation",
"suggest",
"the",
"possibility",
"of",
"previously",
"unrecognized",
"functional",
"motifs",
"."
] | [
"within",
"a",
"135-bp",
"core",
"homology",
"region",
",",
"the",
"human",
"hs12",
"enhancer",
"be",
"approximately",
"90",
"%",
"identical",
"to",
"the",
"murine",
"homolog",
"and",
"include",
"several",
"motif",
"previously",
"demonstrate",
"to",
"be",
"important",
"for",
"function",
"of",
"the",
"murine",
"enhancer",
";",
"additional",
"segment",
"of",
"high",
"sequence",
"conservation",
"suggest",
"the",
"possibility",
"of",
"previously",
"unrecognized",
"functional",
"motif",
"."
] | [
20,
2,
8,
7,
7,
7,
16,
2,
8,
7,
35,
10,
26,
39,
7,
8,
24,
2,
8,
7,
30,
10,
8,
35,
26,
21,
24,
22,
8,
20,
7,
20,
2,
8,
7,
40,
8,
35,
20,
8,
7,
7,
10,
2,
7,
20,
26,
8,
8,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"In",
"contrast",
"to",
"the",
"wild-type",
"protein",
",",
"expression",
"of",
"p45",
"NF-E2",
"lacking",
"this",
"activation",
"domain",
"in",
"an",
"NF-E2",
"null",
"cell",
"line",
"fails",
"to",
"support",
"enhancer",
"dependent",
"transcription",
"in",
"transient",
"assays",
"."
] | [
"in",
"contrast",
"to",
"the",
"wild-type",
"protein",
",",
"expression",
"of",
"p45",
"nf-e2",
"lack",
"this",
"activation",
"domain",
"in",
"a",
"nf-e2",
"null",
"cell",
"line",
"fail",
"to",
"support",
"enhancer",
"dependent",
"transcription",
"in",
"transient",
"assay",
"."
] | [
20,
7,
24,
2,
8,
7,
16,
7,
20,
7,
7,
14,
2,
7,
7,
20,
2,
7,
8,
7,
7,
9,
24,
22,
7,
8,
7,
20,
8,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
0,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"These",
"findings",
"suggest",
"one",
"potential",
"mechanism",
"for",
"direct",
"recruitment",
"of",
"distal",
"regulatory",
"regions",
"of",
"the",
"globin",
"loci",
"to",
"the",
"individual",
"promoters",
"."
] | [
"these",
"finding",
"suggest",
"one",
"potential",
"mechanism",
"for",
"direct",
"recruitment",
"of",
"distal",
"regulatory",
"region",
"of",
"the",
"globin",
"locus",
"to",
"the",
"individual",
"promoter",
"."
] | [
2,
35,
10,
39,
8,
7,
20,
8,
7,
20,
8,
8,
35,
20,
2,
7,
35,
24,
2,
8,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2
] |
[
"The",
"promoter",
"region",
"showed",
"no",
"consensus",
"TATA",
"box",
"but",
"it",
"contains",
"CCAAT",
"and",
"CreA",
"boxes",
"known",
"to",
"be",
"involved",
"in",
"both",
"stress",
"and",
"carbon-catabolite",
"regulation",
"of",
"fungal",
"promoters",
"."
] | [
"the",
"promoter",
"region",
"show",
"no",
"consensus",
"ta",
"box",
"but",
"it",
"contain",
"ccaat",
"and",
"crea",
"box",
"know",
"to",
"be",
"involve",
"in",
"both",
"stress",
"and",
"carbon-catabolite",
"regulation",
"of",
"fungal",
"promoter",
"."
] | [
2,
7,
7,
21,
2,
7,
7,
7,
30,
18,
9,
7,
30,
7,
35,
28,
24,
22,
28,
20,
30,
7,
30,
8,
7,
20,
8,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"por",
"gene",
"has",
"been",
"expressed",
",",
"for",
"the",
"first",
"time",
",",
"in",
"anaerobically",
"grown",
"Escherichia",
"coli",
"behind",
"the",
"isopropyl-beta-D-thiogalactopyranoside",
"inducible",
"tac",
"promoter",
",",
"resulting",
"in",
"the",
"production",
"of",
"POR",
"in",
"its",
"active",
"form",
"."
] | [
"the",
"por",
"gene",
"have",
"be",
"express",
",",
"for",
"the",
"first",
"time",
",",
"in",
"anaerobically",
"grow",
"escherichia",
"coli",
"behind",
"the",
"isopropyl-beta-d-thiogalactopyranoside",
"inducible",
"tac",
"promoter",
",",
"result",
"in",
"the",
"production",
"of",
"por",
"in",
"its",
"active",
"form",
"."
] | [
2,
7,
7,
9,
28,
28,
16,
20,
2,
8,
7,
16,
20,
26,
28,
11,
11,
20,
2,
7,
8,
7,
7,
16,
14,
20,
2,
7,
20,
7,
20,
17,
8,
7,
15
] | [
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2
] |
[
"The",
"ORF3",
"mutant",
"produced",
"reduced",
"levels",
"of",
"tabtoxin",
",",
"indicating",
"that",
"ORF3",
"may",
"have",
"a",
"role",
"in",
"T",
"beta",
"L",
"biosynthesis",
"."
] | [
"the",
"orf3",
"mutant",
"produce",
"reduce",
"level",
"of",
"tabtoxin",
",",
"indicate",
"that",
"orf3",
"may",
"have",
"a",
"role",
"in",
"t",
"beta",
"l",
"biosynthesis",
"."
] | [
2,
7,
7,
21,
28,
35,
20,
7,
16,
14,
20,
7,
13,
22,
2,
7,
20,
7,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2
] |
[
"Refined",
"Cox",
"models",
"using",
"a",
"CD4",
"count",
"of",
"150",
"/",
"microL",
"rather",
"than",
"200",
"/",
"microL",
"to",
"distinguish",
"I0",
"and",
"I1",
"yielded",
"a",
"simplified",
"model",
"with",
"better",
"fit",
"to",
"the",
"observed",
"data",
"."
] | [
"refine",
"cox",
"model",
"use",
"a",
"cd4",
"count",
"of",
"150",
"/",
"microl",
"rather",
"than",
"200",
"/",
"microl",
"to",
"distinguish",
"i0",
"and",
"i1",
"yield",
"a",
"simplify",
"model",
"with",
"better",
"fit",
"to",
"the",
"observe",
"datum",
"."
] | [
28,
7,
35,
14,
2,
7,
7,
20,
39,
40,
7,
26,
20,
39,
40,
7,
24,
22,
7,
30,
7,
21,
2,
28,
7,
20,
41,
7,
24,
2,
28,
35,
15
] | [
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"These",
"transcripts",
"contain",
"the",
"5",
"'",
"ends",
"of",
"mature",
"UbCRBP",
"mRNAs",
";",
"extend",
"through",
"UbCRBP",
",",
"across",
"the",
"intergenic",
"region",
",",
"and",
"a",
"significant",
"distance",
"3",
"'",
"into",
"the",
"enolase",
"gene",
"."
] | [
"these",
"transcript",
"contain",
"the",
"5",
"'",
"end",
"of",
"mature",
"ubcrbp",
"mrna",
";",
"extend",
"through",
"ubcrbp",
",",
"across",
"the",
"intergenic",
"region",
",",
"and",
"a",
"significant",
"distance",
"3",
"'",
"into",
"the",
"enolase",
"gene",
"."
] | [
2,
35,
10,
2,
39,
3,
35,
20,
8,
7,
35,
40,
22,
20,
7,
16,
20,
2,
8,
7,
16,
30,
2,
8,
7,
39,
3,
20,
2,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
[
"Proteasomes",
"are",
"the",
"multisubunit",
"protease",
"involved",
"in",
"the",
"generation",
"of",
"peptides",
"presented",
"by",
"MHC",
"class",
"I",
"molecules",
"."
] | [
"proteasome",
"be",
"the",
"multisubunit",
"protease",
"involve",
"in",
"the",
"generation",
"of",
"peptide",
"present",
"by",
"mhc",
"class",
"i",
"molecule",
"."
] | [
35,
10,
2,
8,
7,
28,
20,
2,
7,
20,
35,
28,
20,
7,
7,
39,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2
] |
[
"In",
"support",
"of",
"this",
"interpretation",
"we",
"demonstrate",
"that",
"MQ9b",
"binds",
"strongly",
"5",
"of",
"17",
"motif",
"positive",
",",
"pathogen",
"derived",
"synthetic",
"peptides",
"."
] | [
"in",
"support",
"of",
"this",
"interpretation",
"we",
"demonstrate",
"that",
"mq9b",
"bind",
"strongly",
"5",
"of",
"17",
"motif",
"positive",
",",
"pathogen",
"derive",
"synthetic",
"peptide",
"."
] | [
20,
7,
20,
2,
7,
18,
10,
20,
7,
9,
26,
39,
20,
39,
7,
8,
16,
7,
28,
8,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"For",
"sputum",
"interleukin-8",
"there",
"was",
"an",
"estimated",
"true",
"treatment",
"median",
"difference",
"of",
"142",
"pg",
"/",
"ml",
"(",
"95",
"%",
"confidence",
"interval",
"(",
"CI",
")",
"8",
"to",
"2866",
"pg",
"/",
"ml",
")",
"in",
"favour",
"of",
"placebo",
";",
"while",
"for",
"maximal",
"expiratory",
"flow",
"at",
"25",
"%",
"(",
"MEF25",
"%",
")",
"remaining",
"forced",
"vital",
"capacity",
"predicted",
"for",
"sex",
"and",
"height",
"there",
"was",
"a",
"15",
"percentage",
"points",
"(",
"pp",
")",
"(",
"95",
"%",
"CI",
"4",
"to",
"26",
"pp",
")",
"mean",
"treatment",
"difference",
"in",
"favour",
"of",
"placebo",
"."
] | [
"for",
"sputum",
"interleukin-8",
"there",
"be",
"a",
"estimate",
"true",
"treatment",
"median",
"difference",
"of",
"142",
"pg",
"/",
"ml",
"(",
"95",
"%",
"confidence",
"interval",
"(",
"ci",
")",
"8",
"to",
"2866",
"pg",
"/",
"ml",
")",
"in",
"favour",
"of",
"placebo",
";",
"while",
"for",
"maximal",
"expiratory",
"flow",
"at",
"25",
"%",
"(",
"mef25",
"%",
")",
"remain",
"forced",
"vital",
"capacity",
"predict",
"for",
"sex",
"and",
"height",
"there",
"be",
"a",
"15",
"percentage",
"point",
"(",
"pp",
")",
"(",
"95",
"%",
"ci",
"4",
"to",
"26",
"pp",
")",
"mean",
"treatment",
"difference",
"in",
"favour",
"of",
"placebo",
"."
] | [
20,
7,
7,
37,
21,
2,
28,
8,
7,
7,
7,
20,
39,
7,
40,
7,
7,
39,
7,
7,
7,
39,
7,
39,
39,
24,
39,
7,
40,
7,
7,
20,
7,
20,
7,
40,
20,
20,
8,
7,
7,
20,
39,
7,
39,
39,
7,
39,
14,
8,
8,
7,
28,
20,
7,
30,
7,
37,
21,
2,
39,
7,
35,
10,
7,
7,
39,
39,
7,
7,
39,
24,
39,
7,
11,
22,
7,
7,
20,
7,
20,
7,
15
] | [
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"However",
",",
"although",
"deletion",
"of",
"Fp1",
"in",
"the",
"hCRBP1",
"gene",
"yielded",
"increased",
"CAT",
"activity",
",",
"pointing",
"toward",
"a",
"negative",
"regulatory",
"function",
"exerted",
"by",
"this",
"element",
",",
"its",
"insertion",
"upstream",
"of",
"the",
"p12",
"basal",
"promoter",
"results",
"in",
"an",
"impressive",
"positive",
"stimulation",
"of",
"CAT",
"gene",
"expression",
"."
] | [
"however",
",",
"although",
"deletion",
"of",
"fp1",
"in",
"the",
"hcrbp1",
"gene",
"yield",
"increase",
"cat",
"activity",
",",
"point",
"toward",
"a",
"negative",
"regulatory",
"function",
"exert",
"by",
"this",
"element",
",",
"its",
"insertion",
"upstream",
"of",
"the",
"p12",
"basal",
"promoter",
"result",
"in",
"a",
"impressive",
"positive",
"stimulation",
"of",
"cat",
"gene",
"expression",
"."
] | [
26,
16,
20,
7,
20,
7,
20,
2,
7,
7,
21,
28,
7,
7,
16,
14,
20,
2,
8,
8,
7,
28,
20,
2,
7,
16,
17,
7,
26,
20,
2,
7,
8,
7,
9,
20,
2,
8,
8,
7,
20,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
0,
2,
2,
0,
1,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2
] |
[
"Gaucher",
"'s",
"disease",
"is",
"a",
"rare",
"metabolic",
"disorder",
"characterized",
"by",
"the",
"lack",
"of",
"beta-glucocerebrosidase",
"enzyme",
"."
] | [
"gaucher",
"'s",
"disease",
"be",
"a",
"rare",
"metabolic",
"disorder",
"characterize",
"by",
"the",
"lack",
"of",
"beta-glucocerebrosidase",
"enzyme",
"."
] | [
7,
34,
7,
9,
2,
8,
8,
7,
28,
20,
2,
7,
20,
8,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
[
"The",
"9",
";",
"22",
"chromosomal",
"translocation",
"characteristic",
"of",
"CML",
"results",
"in",
"a",
"fused",
"bcr",
"/",
"abl",
"gene",
"and",
"an",
"abnormal",
"fusion",
"protein",
",",
"p210bcr",
"/",
"abl",
"."
] | [
"the",
"9",
";",
"22",
"chromosomal",
"translocation",
"characteristic",
"of",
"cml",
"result",
"in",
"a",
"fuse",
"bcr",
"/",
"abl",
"gene",
"and",
"a",
"abnormal",
"fusion",
"protein",
",",
"p210bcr",
"/",
"abl",
"."
] | [
2,
39,
40,
39,
8,
7,
7,
20,
7,
9,
20,
2,
28,
7,
40,
7,
7,
30,
2,
8,
7,
7,
16,
7,
40,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
2
] |
[
"Overexpression",
"of",
"BAG-1",
"also",
"protected",
"certain",
"cell",
"lines",
"from",
"heat",
"shock",
"induced",
"cell",
"death",
"."
] | [
"overexpression",
"of",
"bag-1",
"also",
"protect",
"certain",
"cell",
"line",
"from",
"heat",
"shock",
"induce",
"cell",
"death",
"."
] | [
7,
20,
7,
26,
21,
8,
7,
35,
20,
7,
7,
21,
7,
7,
15
] | [
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"5",
"'",
"flanking",
"region",
"contains",
"potential",
"binding",
"sites",
"for",
"TATA",
"binding",
"protein",
",",
"Sp1",
",",
"nuclear",
"factor",
"1",
"(",
"NF1",
")",
",",
"CAAT-box",
"binding",
"protein",
"(",
"C",
"/",
"EBP",
")",
",",
"hepatocyte",
"nuclear",
"factors",
"1",
"and",
"5",
"(",
"HNF1",
",",
"HNF5",
")",
"and",
"activator",
"proteins",
"1",
"and",
"2",
"(",
"AP1",
",",
"AP2",
")",
"."
] | [
"the",
"5",
"'",
"flanking",
"region",
"contain",
"potential",
"binding",
"site",
"for",
"ta",
"binding",
"protein",
",",
"sp1",
",",
"nuclear",
"factor",
"1",
"(",
"nf1",
")",
",",
"caat-box",
"binding",
"protein",
"(",
"c",
"/",
"ebp",
")",
",",
"hepatocyte",
"nuclear",
"factor",
"1",
"and",
"5",
"(",
"hnf1",
",",
"hnf5",
")",
"and",
"activator",
"protein",
"1",
"and",
"2",
"(",
"ap1",
",",
"ap2",
")",
"."
] | [
2,
39,
3,
8,
7,
9,
8,
7,
35,
20,
7,
7,
7,
16,
7,
16,
8,
7,
39,
39,
7,
7,
16,
7,
7,
7,
7,
7,
40,
7,
7,
16,
7,
8,
35,
39,
30,
39,
39,
7,
16,
7,
7,
30,
7,
35,
39,
30,
39,
39,
7,
16,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
0,
2,
0,
1,
1,
2,
0,
2,
2,
0,
1,
1,
2,
0,
1,
1,
2,
2,
0,
1,
1,
1,
1,
1,
2,
0,
2,
0,
2,
2,
0,
1,
1,
1,
1,
2,
0,
2,
0,
2,
2
] |
[
"The",
"recognition",
"specificity",
"of",
"the",
"p55",
"PDZ",
"domain",
"appears",
"to",
"be",
"unique",
",",
"since",
"the",
"three",
"PDZ",
"domains",
"of",
"hDlg",
"(",
"human",
"lymphocyte",
"homologue",
"of",
"the",
"Drosophila",
"discs",
"large",
"tumor",
"suppressor",
")",
"do",
"not",
"bind",
"the",
"cytoplasmic",
"domain",
"of",
"glycophorin",
"C."
] | [
"the",
"recognition",
"specificity",
"of",
"the",
"p55",
"pdz",
"domain",
"appear",
"to",
"be",
"unique",
",",
"since",
"the",
"three",
"PDZ",
"domain",
"of",
"hdlg",
"(",
"human",
"lymphocyte",
"homologue",
"of",
"the",
"drosophila",
"disc",
"large",
"tumor",
"suppressor",
")",
"do",
"not",
"bind",
"the",
"cytoplasmic",
"domain",
"of",
"glycophorin",
"c."
] | [
2,
7,
7,
20,
2,
7,
7,
7,
9,
24,
22,
8,
16,
20,
2,
39,
36,
35,
20,
7,
39,
8,
7,
7,
20,
2,
11,
35,
8,
7,
7,
39,
10,
26,
22,
2,
8,
7,
20,
7,
7
] | [
2,
2,
2,
2,
2,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
0,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1
] |
[
"By",
"analyzing",
"the",
"RanGAP",
"activity",
"of",
"a",
"series",
"of",
"recombinantly",
"expressed",
"rna1p",
"mutant",
"derivatives",
",",
"we",
"show",
"that",
"the",
"highly",
"acidic",
"sequence",
"in",
"the",
"C-terminal",
"domain",
"of",
"both",
"yeast",
"proteins",
"is",
"indispensable",
"for",
"activating",
"Ran",
"mediated",
"GTP",
"hydrolysis",
"."
] | [
"by",
"analyze",
"the",
"rangap",
"activity",
"of",
"a",
"series",
"of",
"recombinantly",
"express",
"rna1p",
"mutant",
"derivative",
",",
"we",
"show",
"that",
"the",
"highly",
"acidic",
"sequence",
"in",
"the",
"c-terminal",
"domain",
"of",
"both",
"yeast",
"protein",
"be",
"indispensable",
"for",
"activate",
"ran",
"mediate",
"gtp",
"hydrolysis",
"."
] | [
20,
14,
2,
7,
7,
20,
2,
7,
20,
26,
28,
7,
7,
35,
16,
18,
10,
20,
2,
26,
8,
7,
20,
2,
8,
7,
20,
30,
7,
35,
9,
8,
20,
14,
7,
21,
7,
7,
15
] | [
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2
] |
[
"In",
"the",
"absence",
"of",
"MHC",
"class",
"II",
",",
"purified",
"soluble",
"D10",
"TCR",
"bound",
"to",
"Staphylococcus",
"aureus",
"enterotoxin",
"C2",
"with",
"an",
"association",
"rate",
"of",
"1.69+",
"/",
"-0.12",
"x",
"10",
"(",
"4",
")",
"M",
"(",
"-1",
")",
"sec",
"(",
"-1",
")",
"and",
"a",
"dissociation",
"rate",
"of",
"1.9+",
"/",
"-0.47",
"x",
"10",
"(",
"-2",
")",
"sec",
"(",
"-1",
")",
",",
"giving",
"a",
"dissociation",
"constant",
"of",
"1.1",
"microM",
"."
] | [
"in",
"the",
"absence",
"of",
"mhc",
"class",
"ii",
",",
"purify",
"soluble",
"d10",
"tcr",
"bind",
"to",
"staphylococcus",
"aureus",
"enterotoxin",
"c2",
"with",
"a",
"association",
"rate",
"of",
"1.69+",
"/",
"-0.12",
"x",
"10",
"(",
"4",
")",
"m",
"(",
"-1",
")",
"sec",
"(",
"-1",
")",
"and",
"a",
"dissociation",
"rate",
"of",
"1.9+",
"/",
"-0.47",
"x",
"10",
"(",
"-2",
")",
"sec",
"(",
"-1",
")",
",",
"give",
"a",
"dissociation",
"constant",
"of",
"1.1",
"microm",
"."
] | [
20,
2,
7,
20,
7,
7,
39,
16,
28,
8,
7,
7,
21,
24,
11,
11,
7,
7,
20,
2,
7,
7,
20,
39,
40,
39,
30,
39,
39,
39,
39,
7,
39,
39,
39,
7,
39,
39,
7,
30,
2,
7,
7,
20,
39,
40,
39,
30,
39,
39,
39,
39,
7,
39,
39,
7,
16,
14,
2,
7,
7,
20,
39,
7,
15
] | [
2,
2,
2,
2,
0,
1,
1,
2,
0,
1,
1,
1,
2,
2,
0,
1,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Mnt",
":",
"Max",
"complexes",
"also",
"efficiently",
"suppress",
"Myc",
"dependent",
"activation",
"from",
"the",
"same",
"promoter",
"."
] | [
"mnt",
":",
"Max",
"complex",
"also",
"efficiently",
"suppress",
"myc",
"dependent",
"activation",
"from",
"the",
"same",
"promoter",
"."
] | [
7,
40,
36,
35,
26,
26,
22,
7,
8,
7,
20,
2,
8,
7,
15
] | [
0,
2,
0,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2
] |
[
"In",
"the",
"United",
"States",
"high-MW",
"HES",
"480",
"which",
"is",
"difficult",
"to",
"degrade",
"is",
"most",
"frequently",
"used",
"and",
"results",
"in",
"a",
"larger",
"in",
"vivo",
"MW",
"and",
"subsequent",
"decrease",
"in",
"factor",
"VIII",
"/",
"von",
"Willebrand",
"factor",
"levels",
"."
] | [
"in",
"the",
"United",
"States",
"high-mw",
"he",
"480",
"which",
"be",
"difficult",
"to",
"degrade",
"be",
"most",
"frequently",
"use",
"and",
"result",
"in",
"a",
"larger",
"in",
"vivo",
"mw",
"and",
"subsequent",
"decrease",
"in",
"factor",
"viii",
"/",
"von",
"willebrand",
"factor",
"level",
"."
] | [
20,
2,
36,
27,
8,
7,
39,
33,
9,
8,
24,
22,
9,
31,
26,
28,
30,
9,
20,
2,
41,
11,
11,
7,
30,
8,
7,
20,
7,
39,
40,
7,
7,
7,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
0,
1,
1,
2,
2
] |
[
"Assays",
"of",
"total",
"cholesterol",
"as",
"well",
"as",
"the",
"HDL",
",",
"HDL2",
",",
"LDL",
",",
"triglycerides",
",",
"endothelin-1",
",",
"lipoprotein",
"(",
"a",
")",
",",
"estradiol",
"and",
"FSH",
"were",
"also",
"obtained",
"at",
"baseline",
"before",
"receiving",
"ERT",
"and",
"after",
"3",
"months",
"of",
"ERT",
"."
] | [
"assay",
"of",
"total",
"cholesterol",
"as",
"well",
"as",
"the",
"HDL",
",",
"hdl2",
",",
"ldl",
",",
"triglyceride",
",",
"endothelin-1",
",",
"lipoprotein",
"(",
"a",
")",
",",
"estradiol",
"and",
"fsh",
"be",
"also",
"obtain",
"at",
"baseline",
"before",
"receive",
"ERT",
"and",
"after",
"3",
"month",
"of",
"ert",
"."
] | [
35,
20,
8,
7,
26,
26,
20,
2,
36,
16,
7,
16,
7,
16,
35,
16,
7,
16,
7,
21,
2,
7,
16,
7,
30,
7,
21,
26,
28,
20,
7,
20,
14,
36,
30,
20,
39,
35,
20,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
2,
0,
2,
2,
2,
0,
2,
0,
1,
1,
1,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Six",
"tandem",
"repeats",
"of",
"the",
"P",
"element",
"linked",
"to",
"the",
"SV40",
"promoter",
"responded",
"to",
"phorbol",
"12-myristate",
"13-acetate",
",",
"while",
"that",
"of",
"other",
"elements",
"did",
"not",
"."
] | [
"six",
"tandem",
"repeat",
"of",
"the",
"p",
"element",
"link",
"to",
"the",
"sv40",
"promoter",
"respond",
"to",
"phorbol",
"12-myristate",
"13-acetate",
",",
"while",
"that",
"of",
"other",
"element",
"do",
"not",
"."
] | [
39,
8,
35,
20,
2,
7,
7,
28,
24,
2,
7,
7,
21,
24,
7,
7,
7,
16,
20,
2,
20,
8,
35,
21,
26,
15
] | [
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"cleavage",
"dipeptides",
"of",
"C1YVV",
"NIa",
"protease",
"are",
"Q",
"(",
"E",
")",
"/",
"S",
"(",
"A",
",",
"G",
")",
"."
] | [
"the",
"cleavage",
"dipeptide",
"of",
"c1yvv",
"nium",
"protease",
"be",
"Q",
"(",
"e",
")",
"/",
"s",
"(",
"a",
",",
"g",
")",
"."
] | [
2,
7,
35,
20,
7,
7,
7,
10,
36,
39,
7,
39,
40,
7,
7,
7,
16,
7,
35,
15
] | [
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"In",
"our",
"previous",
"studies",
",",
"transcriptional",
"activation",
"was",
"shown",
"to",
"correlate",
"with",
"IEP86",
"binding",
"to",
"both",
"the",
"TATA-box",
"binding",
"protein",
"(",
"TBP",
")",
"and",
"the",
"transcription",
"factor",
"bound",
"upstream",
"."
] | [
"in",
"we",
"previous",
"study",
",",
"transcriptional",
"activation",
"be",
"show",
"to",
"correlate",
"with",
"iep86",
"binding",
"to",
"both",
"the",
"tata-box",
"binding",
"protein",
"(",
"tbp",
")",
"and",
"the",
"transcription",
"factor",
"bind",
"upstream",
"."
] | [
20,
17,
8,
35,
16,
8,
7,
21,
28,
24,
22,
20,
7,
7,
24,
30,
2,
7,
7,
7,
39,
7,
7,
30,
2,
7,
7,
21,
26,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
0,
1,
1,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"However",
",",
"we",
"were",
"unable",
"to",
"identify",
"a",
"p4",
"molecule",
"."
] | [
"however",
",",
"we",
"be",
"unable",
"to",
"identify",
"a",
"p4",
"molecule",
"."
] | [
26,
16,
18,
21,
8,
24,
22,
2,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2
] |
[
"(",
"iv",
")",
"The",
"accumulation",
"of",
"cyclin",
"D3",
"protein",
"in",
"Vero",
"cells",
"infected",
"with",
"an",
"alpha0",
"deletion",
"mutant",
"was",
"reduced",
"relative",
"to",
"that",
"of",
"cells",
"infected",
"with",
"wild-type",
"virus",
"or",
"a",
"recombinant",
"virus",
"in",
"which",
"the",
"deleted",
"alpha0",
"sequences",
"were",
"restored",
"."
] | [
"(",
"iv",
")",
"the",
"accumulation",
"of",
"cyclin",
"d3",
"protein",
"in",
"vero",
"cell",
"infect",
"with",
"a",
"alpha0",
"deletion",
"mutant",
"be",
"reduce",
"relative",
"to",
"that",
"of",
"cell",
"infect",
"with",
"wild-type",
"virus",
"or",
"a",
"recombinant",
"virus",
"in",
"which",
"the",
"delete",
"alpha0",
"sequence",
"be",
"restore",
"."
] | [
7,
7,
39,
2,
7,
20,
7,
7,
7,
20,
7,
35,
28,
20,
2,
7,
7,
7,
21,
28,
8,
24,
2,
20,
35,
28,
20,
8,
7,
30,
2,
8,
7,
20,
33,
2,
28,
7,
35,
21,
28,
15
] | [
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2
] |
[
"We",
"report",
"the",
"preliminary",
"biochemical",
"characterization",
"of",
"the",
"T",
"antigens",
"encoded",
"by",
"three",
"SV40",
"mutants",
",",
"5030",
",",
"5031",
",",
"and",
"5061",
",",
"each",
"of",
"which",
"have",
"altered",
"residues",
"within",
"or",
"near",
"the",
"ATP",
"binding",
"pocket",
"."
] | [
"we",
"report",
"the",
"preliminary",
"biochemical",
"characterization",
"of",
"the",
"t",
"antigen",
"encode",
"by",
"three",
"sv40",
"mutant",
",",
"5030",
",",
"5031",
",",
"and",
"5061",
",",
"each",
"of",
"which",
"have",
"alter",
"residue",
"within",
"or",
"near",
"the",
"atp",
"binding",
"pocket",
"."
] | [
18,
10,
2,
8,
8,
7,
20,
2,
7,
35,
28,
20,
39,
7,
35,
16,
39,
16,
39,
16,
30,
39,
16,
2,
20,
33,
10,
28,
35,
20,
30,
20,
2,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"These",
"effects",
"were",
"abrogated",
"by",
"co",
"expression",
"of",
"kinase",
"deficient",
"PKC",
"zeta",
"and",
"inhibition",
"of",
"phosphatidylinositol",
"3-kinase",
"p85alpha-p110",
"by",
"wortmannin",
",",
"LY294002",
"and",
"a",
"dominant",
"negative",
"mutant",
"of",
"p85alpha",
"."
] | [
"these",
"effect",
"be",
"abrogate",
"by",
"co",
"expression",
"of",
"kinase",
"deficient",
"pkc",
"zeta",
"and",
"inhibition",
"of",
"phosphatidylinositol",
"3-kinase",
"p85alpha-p110",
"by",
"wortmannin",
",",
"ly294002",
"and",
"a",
"dominant",
"negative",
"mutant",
"of",
"p85alpha",
"."
] | [
2,
35,
21,
28,
20,
7,
7,
20,
7,
8,
7,
7,
30,
7,
20,
7,
7,
7,
20,
7,
16,
7,
30,
2,
8,
8,
7,
20,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2,
2,
2,
0,
1,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2
] |
[
"Protein",
"phosphatase",
"2A",
"is",
"a",
"critical",
"regulator",
"of",
"protein",
"kinase",
"C",
"zeta",
"signaling",
"targeted",
"by",
"SV40",
"small",
"t",
"to",
"promote",
"cell",
"growth",
"and",
"NF-kappaB",
"activation",
"."
] | [
"protein",
"phosphatase",
"2a",
"be",
"a",
"critical",
"regulator",
"of",
"protein",
"kinase",
"c",
"zeta",
"signaling",
"target",
"by",
"sv40",
"small",
"t",
"to",
"promote",
"cell",
"growth",
"and",
"nf-kappab",
"activation",
"."
] | [
7,
7,
7,
9,
2,
8,
7,
20,
7,
7,
7,
7,
7,
28,
20,
7,
8,
7,
24,
22,
7,
7,
30,
7,
7,
15
] | [
0,
1,
1,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
0,
2,
2
] |
[
"Interestingly",
",",
"the",
"RXRalphaF318A",
"constitutive",
"activity",
"generated",
"within",
"heterodimers",
"in",
"the",
"presence",
"of",
"BMS614",
"requires",
"the",
"integrity",
"of",
"both",
"RXR",
"and",
"RAR",
"AF-2",
"domains",
"."
] | [
"interestingly",
",",
"the",
"rxralphaf318a",
"constitutive",
"activity",
"generate",
"within",
"heterodimer",
"in",
"the",
"presence",
"of",
"bms614",
"require",
"the",
"integrity",
"of",
"both",
"rxr",
"and",
"rar",
"af-2",
"domain",
"."
] | [
26,
16,
2,
7,
8,
7,
28,
20,
35,
20,
2,
7,
20,
7,
9,
2,
7,
20,
30,
7,
30,
7,
7,
35,
15
] | [
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
2,
2,
2
] |
[
"These",
"introns",
"contain",
"only",
"single",
"snoRNA",
"genes",
"and",
"their",
"processing",
"involves",
"exonucleolytic",
"release",
"of",
"the",
"snoRNA",
"from",
"debranched",
"intron",
"lariats",
"."
] | [
"these",
"intron",
"contain",
"only",
"single",
"snorna",
"gene",
"and",
"they",
"processing",
"involve",
"exonucleolytic",
"release",
"of",
"the",
"snorna",
"from",
"debranched",
"intron",
"lariat",
"."
] | [
2,
35,
10,
26,
8,
7,
35,
30,
17,
7,
9,
8,
7,
20,
2,
7,
20,
8,
7,
35,
15
] | [
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Recent",
"studies",
"have",
"shown",
"that",
"the",
"Src",
"homology-2",
"(",
"SH2",
")",
"domain",
"containing",
"protein-tyrosine",
"phosphatase",
",",
"SHP-2",
",",
"associates",
"with",
"the",
"cytoplasmic",
"domain",
"of",
"PECAM-1",
"as",
"it",
"becomes",
"tyrosine",
"phosphorylated",
"during",
"platelet",
"aggregation",
":",
"a",
"process",
"that",
"can",
"be",
"mimicked",
"in",
"part",
"by",
"small",
"synthetic",
"phosphopeptides",
"corresponding",
"to",
"the",
"cytoplasmic",
"domain",
"of",
"PECAM-1",
"encompassing",
"tyrosine",
"residues",
"Tyr-663",
"or",
"Tyr-686",
"."
] | [
"recent",
"study",
"have",
"show",
"that",
"the",
"src",
"homology-2",
"(",
"sh2",
")",
"domain",
"contain",
"protein-tyrosine",
"phosphatase",
",",
"shp-2",
",",
"associate",
"with",
"the",
"cytoplasmic",
"domain",
"of",
"pecam-1",
"as",
"it",
"become",
"tyrosine",
"phosphorylate",
"during",
"platelet",
"aggregation",
":",
"a",
"process",
"that",
"can",
"be",
"mimic",
"in",
"part",
"by",
"small",
"synthetic",
"phosphopeptide",
"correspond",
"to",
"the",
"cytoplasmic",
"domain",
"of",
"pecam-1",
"encompass",
"tyrosine",
"residue",
"tyr-663",
"or",
"tyr-686",
"."
] | [
8,
35,
10,
28,
20,
2,
7,
7,
39,
7,
7,
7,
14,
8,
7,
16,
7,
16,
9,
20,
2,
8,
7,
20,
7,
20,
18,
9,
7,
28,
20,
7,
7,
40,
2,
7,
33,
13,
22,
28,
20,
7,
20,
8,
8,
35,
14,
24,
2,
8,
7,
20,
7,
14,
7,
35,
7,
30,
7,
15
] | [
2,
2,
2,
2,
2,
2,
0,
1,
2,
0,
2,
2,
2,
0,
1,
2,
0,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2
] |
[
"Supplementation",
"was",
"stopped",
"when",
"pl-ALB",
"reached",
"2.0",
"g",
"/",
"dL",
"."
] | [
"supplementation",
"be",
"stop",
"when",
"pl-alb",
"reach",
"2.0",
"g",
"/",
"dl",
"."
] | [
7,
21,
28,
0,
7,
21,
39,
7,
40,
7,
15
] | [
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2
] |
[
"These",
"findings",
"show",
"that",
"EBP50",
"is",
"a",
"physiologically",
"relevant",
"ezrin",
"binding",
"protein",
"."
] | [
"these",
"finding",
"show",
"that",
"ebp50",
"be",
"a",
"physiologically",
"relevant",
"ezrin",
"binding",
"protein",
"."
] | [
2,
35,
10,
20,
7,
9,
2,
26,
8,
7,
7,
7,
15
] | [
2,
2,
2,
2,
0,
2,
2,
2,
2,
0,
1,
1,
2
] |
[
"Previously",
",",
"we",
"reported",
"that",
"scanthrough",
"translation",
",",
"where",
"the",
"initiating",
"AUG",
"of",
"a",
"primary",
"open",
"reading",
"frame",
"is",
"bypassed",
",",
"is",
"most",
"likely",
"to",
"account",
"for",
"the",
"presentation",
"of",
"cryptic",
"epitopes",
"from",
"alternative",
"reading",
"frames",
"within",
"the",
"influenza",
"A",
"PR",
"/",
"8/34",
"nucleoprotein",
"gene",
"."
] | [
"previously",
",",
"we",
"report",
"that",
"scanthrough",
"translation",
",",
"where",
"the",
"initiate",
"aug",
"of",
"a",
"primary",
"open",
"reading",
"frame",
"be",
"bypass",
",",
"be",
"most",
"likely",
"to",
"account",
"for",
"the",
"presentation",
"of",
"cryptic",
"epitope",
"from",
"alternative",
"reading",
"frame",
"within",
"the",
"influenza",
"a",
"pr",
"/",
"8/34",
"nucleoprotein",
"gene",
"."
] | [
26,
16,
18,
21,
20,
8,
7,
16,
0,
2,
14,
7,
20,
2,
8,
8,
7,
7,
9,
28,
16,
9,
31,
8,
24,
22,
20,
2,
7,
20,
8,
35,
20,
8,
7,
35,
20,
2,
7,
7,
7,
40,
39,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
1,
1,
1,
2
] |
[
"Deletion",
"of",
"the",
"POR2",
"gene",
"alone",
"had",
"no",
"detectable",
"phenotype",
",",
"while",
"yeasts",
"with",
"deletions",
"of",
"both",
"the",
"POR1",
"and",
"POR2",
"genes",
"were",
"viable",
"and",
"able",
"to",
"grow",
"on",
"glycerol",
"at",
"30",
"degrees",
"C",
",",
"albeit",
"more",
"slowly",
"than",
"delta",
"por1",
"single",
"mutants",
"."
] | [
"deletion",
"of",
"the",
"por2",
"gene",
"alone",
"have",
"no",
"detectable",
"phenotype",
",",
"while",
"yeast",
"with",
"deletion",
"of",
"both",
"the",
"por1",
"and",
"por2",
"gene",
"be",
"viable",
"and",
"able",
"to",
"grow",
"on",
"glycerol",
"at",
"30",
"degree",
"c",
",",
"albeit",
"more",
"slowly",
"than",
"delta",
"por1",
"single",
"mutant",
"."
] | [
7,
20,
2,
7,
7,
26,
21,
2,
8,
7,
16,
20,
35,
20,
35,
20,
30,
2,
7,
30,
7,
35,
21,
8,
30,
8,
24,
22,
20,
7,
20,
39,
35,
7,
16,
20,
12,
26,
20,
7,
7,
8,
35,
15
] | [
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2
] |
[
"Furthermore",
",",
"our",
"novel",
"observation",
"that",
"expression",
"of",
"a",
"highly",
"activated",
"FGFR3",
"kinase",
"domain",
"is",
"able",
"to",
"morphologically",
"transform",
"fibroblasts",
"suggests",
"that",
"dysregulation",
"of",
"FGFR3",
"has",
"the",
"potential",
"to",
"play",
"a",
"role",
"in",
"human",
"neoplasia",
"."
] | [
"furthermore",
",",
"we",
"novel",
"observation",
"that",
"expression",
"of",
"a",
"highly",
"activate",
"fgfr3",
"kinase",
"domain",
"be",
"able",
"to",
"morphologically",
"transform",
"fibroblast",
"suggest",
"that",
"dysregulation",
"of",
"fgfr3",
"have",
"the",
"potential",
"to",
"play",
"a",
"role",
"in",
"human",
"neoplasium",
"."
] | [
26,
16,
17,
8,
7,
20,
7,
20,
2,
26,
28,
7,
7,
7,
9,
8,
24,
26,
22,
35,
9,
20,
7,
20,
7,
9,
2,
8,
24,
22,
2,
7,
20,
8,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"deduced",
"amino",
"acid",
"sequence",
"of",
"the",
"gene",
"has",
"significant",
"homology",
"to",
"the",
"interferon",
"regulatory",
"factors",
"(",
"IRFs",
")",
"."
] | [
"the",
"deduce",
"amino",
"acid",
"sequence",
"of",
"the",
"gene",
"have",
"significant",
"homology",
"to",
"the",
"interferon",
"regulatory",
"factor",
"(",
"irf",
")",
"."
] | [
2,
28,
7,
7,
7,
20,
2,
7,
9,
8,
7,
24,
2,
7,
8,
35,
10,
35,
39,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
0,
2,
2
] |
[
"Involvement",
"of",
"AP-2",
"in",
"regulation",
"of",
"the",
"R-FABP",
"gene",
"in",
"the",
"developing",
"chick",
"retina",
"."
] | [
"involvement",
"of",
"ap-2",
"in",
"regulation",
"of",
"the",
"r-fabp",
"gene",
"in",
"the",
"develop",
"chick",
"retina",
"."
] | [
7,
20,
7,
20,
7,
20,
2,
7,
7,
20,
2,
14,
7,
7,
15
] | [
2,
2,
0,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2
] |
[
"However",
",",
"Cbf5p",
"was",
"found",
"to",
"be",
"nucleolar",
"and",
"is",
"highly",
"homologous",
"to",
"the",
"rat",
"nucleolar",
"protein",
"NAP57",
",",
"which",
"coimmunoprecipitates",
"with",
"Nopp140",
"and",
"which",
"is",
"postulated",
"to",
"be",
"involved",
"in",
"nucleolar",
"cytoplasmic",
"shuttling",
"(",
"U."
] | [
"however",
",",
"cbf5p",
"be",
"find",
"to",
"be",
"nucleolar",
"and",
"be",
"highly",
"homologous",
"to",
"the",
"rat",
"nucleolar",
"protein",
"nap57",
",",
"which",
"coimmunoprecipitate",
"with",
"nopp140",
"and",
"which",
"be",
"postulate",
"to",
"be",
"involve",
"in",
"nucleolar",
"cytoplasmic",
"shuttling",
"(",
"U."
] | [
26,
16,
7,
21,
28,
24,
22,
8,
30,
9,
26,
8,
24,
2,
7,
8,
7,
7,
16,
33,
9,
20,
7,
30,
33,
9,
28,
24,
22,
28,
20,
8,
8,
7,
39,
36
] | [
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Ig",
"heavy",
"chain",
"class",
"switching",
"is",
"directed",
"by",
"cytokines",
"inducing",
"transcription",
"from",
"unrearranged",
"CH",
"genes",
"."
] | [
"ig",
"heavy",
"chain",
"class",
"switching",
"be",
"direct",
"by",
"cytokine",
"induce",
"transcription",
"from",
"unrearranged",
"ch",
"gene",
"."
] | [
7,
8,
7,
7,
7,
9,
28,
20,
35,
14,
7,
20,
8,
7,
35,
15
] | [
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
[
"The",
"available",
"data",
"suggest",
"that",
"the",
"NF",
"kappa",
"B2",
"nucleoprotein",
"complex",
"may",
"cooperate",
"with",
"DNA",
"bound",
"STAT6",
"to",
"achieve",
"IL-4",
"dependent",
"activation",
"of",
"the",
"human",
"IgE",
"germline",
"gene",
"."
] | [
"the",
"available",
"datum",
"suggest",
"that",
"the",
"nf",
"kappa",
"b2",
"nucleoprotein",
"complex",
"may",
"cooperate",
"with",
"dna",
"bind",
"stat6",
"to",
"achieve",
"il-4",
"dependent",
"activation",
"of",
"the",
"human",
"ige",
"germline",
"gene",
"."
] | [
2,
8,
35,
10,
20,
2,
7,
7,
7,
7,
7,
13,
22,
20,
7,
21,
7,
24,
22,
7,
8,
7,
20,
2,
8,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
1,
2,
2,
2,
2,
2,
0,
2,
2,
0,
2,
2,
2,
2,
0,
1,
1,
1,
2
] |
[
"The",
"pheromone",
"response",
"pathway",
"activates",
"transcription",
"of",
"Ty5",
"retrotransposons",
"located",
"within",
"silent",
"chromatin",
"of",
"Saccharomyces",
"cerevisiae",
"."
] | [
"the",
"pheromone",
"response",
"pathway",
"activate",
"transcription",
"of",
"ty5",
"retrotransposon",
"located",
"within",
"silent",
"chromatin",
"of",
"saccharomyces",
"cerevisiae",
"."
] | [
2,
7,
7,
7,
9,
7,
20,
7,
35,
8,
20,
8,
7,
20,
11,
11,
15
] | [
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"In",
"this",
"study",
"we",
"have",
"introduced",
"mutations",
"into",
"the",
"corresponding",
"elements",
"of",
"two",
"cox3",
"promoters",
"and",
"show",
"that",
"while",
"the",
"core",
"element",
"is",
"essential",
"for",
"cox3",
"promoter",
"activity",
",",
"upstream",
"element",
"mutations",
"have",
"little",
"or",
"no",
"effect",
"."
] | [
"in",
"this",
"study",
"we",
"have",
"introduce",
"mutation",
"into",
"the",
"corresponding",
"element",
"of",
"two",
"cox3",
"promoter",
"and",
"show",
"that",
"while",
"the",
"core",
"element",
"be",
"essential",
"for",
"cox3",
"promoter",
"activity",
",",
"upstream",
"element",
"mutation",
"have",
"little",
"or",
"no",
"effect",
"."
] | [
20,
2,
7,
18,
10,
28,
35,
20,
2,
8,
35,
20,
39,
7,
35,
30,
10,
20,
20,
2,
7,
7,
9,
8,
20,
7,
7,
7,
16,
8,
7,
35,
10,
8,
30,
2,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"We",
"found",
"that",
"multiple",
"tumor",
"suppressor",
"genes",
"(",
"e.g.",
",",
"p53",
",",
"DCC",
",",
"APC",
",",
"MCC",
",",
"BRCA1",
",",
"and",
"WAF1",
"/",
"CIP1",
")",
"were",
"inactivated",
"at",
"different",
"frequencies",
"via",
"various",
"mechanisms",
"[",
"e.g.",
",",
"loss",
"of",
"heterozygosity",
"(",
"LOH",
")",
",",
"loss",
"of",
"expression",
"(",
"LOE",
")",
",",
"mutation",
",",
"and",
"inactivation",
"by",
"cellular",
"binding",
"protein",
"]",
"."
] | [
"we",
"find",
"that",
"multiple",
"tumor",
"suppressor",
"gene",
"(",
"e.g.",
",",
"p53",
",",
"DCC",
",",
"apc",
",",
"mcc",
",",
"brca1",
",",
"and",
"waf1",
"/",
"cip1",
")",
"be",
"inactivate",
"at",
"different",
"frequency",
"via",
"various",
"mechanism",
"[",
"e.g.",
",",
"loss",
"of",
"heterozygosity",
"(",
"loh",
")",
",",
"loss",
"of",
"expression",
"(",
"loe",
")",
",",
"mutation",
",",
"and",
"inactivation",
"by",
"cellular",
"binding",
"protein",
"]",
"."
] | [
18,
21,
20,
8,
7,
7,
35,
10,
11,
16,
7,
16,
36,
16,
7,
16,
7,
16,
7,
16,
30,
7,
40,
7,
7,
21,
28,
20,
8,
35,
20,
8,
35,
10,
11,
16,
7,
20,
7,
39,
7,
7,
16,
7,
20,
7,
39,
7,
7,
16,
7,
16,
30,
7,
20,
8,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
2,
0,
2,
0,
2,
0,
2,
2,
0,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"histidine",
"tagged",
"gene",
",",
"rpoCHIS",
",",
"was",
"used",
"to",
"replace",
"the",
"wild-type",
"allele",
"in",
"the",
"chromosome",
"of",
"S.",
"coelicolor",
"and",
"S.",
"lividans",
"."
] | [
"the",
"histidine",
"tag",
"gene",
",",
"rpochi",
",",
"be",
"use",
"to",
"replace",
"the",
"wild-type",
"allele",
"in",
"the",
"chromosome",
"of",
"S.",
"coelicolor",
"and",
"S.",
"lividan",
"."
] | [
2,
7,
28,
7,
16,
7,
16,
21,
28,
24,
22,
2,
8,
7,
20,
2,
7,
20,
36,
7,
30,
36,
35,
15
] | [
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Because",
"the",
"deletion",
"included",
"the",
"TK",
"gene",
",",
"selection",
"with",
"gancyclovir",
"against",
"cells",
"not",
"having",
"undergone",
"recombination",
"was",
"possible",
"."
] | [
"because",
"the",
"deletion",
"include",
"the",
"tk",
"gene",
",",
"selection",
"with",
"gancyclovir",
"against",
"cell",
"not",
"have",
"undergo",
"recombination",
"be",
"possible",
"."
] | [
20,
2,
7,
21,
2,
7,
7,
16,
7,
20,
7,
20,
35,
26,
14,
28,
7,
21,
8,
15
] | [
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"malate",
"synthase",
"gene",
",",
"MLS1",
",",
"of",
"the",
"yeast",
"Saccharomyces",
"cerevisiae",
"is",
"transcriptionally",
"regulated",
"by",
"the",
"carbon",
"source",
"in",
"the",
"growth",
"medium",
"."
] | [
"the",
"malate",
"synthase",
"gene",
",",
"mls1",
",",
"of",
"the",
"yeast",
"saccharomyces",
"cerevisiae",
"be",
"transcriptionally",
"regulate",
"by",
"the",
"carbon",
"source",
"in",
"the",
"growth",
"medium",
"."
] | [
2,
7,
7,
7,
16,
7,
16,
20,
2,
7,
11,
11,
9,
26,
28,
20,
2,
7,
7,
20,
2,
7,
7,
15
] | [
2,
0,
1,
1,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"By",
"deletion",
"analysis",
"of",
"the",
"MLS1",
"control",
"region",
",",
"we",
"identified",
"two",
"sites",
",",
"UAS1",
"and",
"UAS2",
",",
"as",
"important",
"for",
"efficient",
"derepression",
"of",
"the",
"gene",
"."
] | [
"by",
"deletion",
"analysis",
"of",
"the",
"mls1",
"control",
"region",
",",
"we",
"identify",
"two",
"site",
",",
"uas1",
"and",
"uas2",
",",
"as",
"important",
"for",
"efficient",
"derepression",
"of",
"the",
"gene",
"."
] | [
20,
7,
7,
20,
2,
7,
7,
7,
16,
18,
21,
39,
35,
16,
7,
30,
7,
16,
26,
8,
20,
8,
7,
20,
2,
7,
15
] | [
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Substrates",
"include",
"the",
"p21",
"(",
"ras",
")",
"proteins",
",",
"nuclear",
"lamins",
",",
"and",
"a",
"series",
"of",
"retinal",
"proteins",
"."
] | [
"substrate",
"include",
"the",
"p21",
"(",
"ra",
")",
"protein",
",",
"nuclear",
"lamin",
",",
"and",
"a",
"series",
"of",
"retinal",
"protein",
"."
] | [
35,
10,
2,
7,
39,
7,
7,
35,
16,
8,
35,
16,
30,
2,
7,
20,
8,
35,
15
] | [
2,
2,
2,
0,
2,
0,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"Trx-CT",
"fusion",
"protein",
"was",
"produced",
"less",
"efficiently",
"(",
"20",
"%",
"of",
"total",
"soluble",
"cellular",
"protein",
")",
"."
] | [
"the",
"trx-ct",
"fusion",
"protein",
"be",
"produce",
"less",
"efficiently",
"(",
"20",
"%",
"of",
"total",
"soluble",
"cellular",
"protein",
")",
"."
] | [
2,
8,
7,
7,
21,
28,
12,
26,
26,
39,
7,
20,
8,
8,
8,
7,
7,
15
] | [
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"These",
"results",
"suggest",
"that",
"UBP41",
"may",
"play",
"an",
"important",
"role",
"in",
"the",
"recycling",
"of",
"ubiquitin",
"by",
"hydrolysis",
"of",
"branched",
"poly-ubiquitin",
"chains",
"generated",
"by",
"the",
"action",
"of",
"26",
"S",
"proteasome",
"on",
"poly",
"ubiquitinated",
"protein",
"substrates",
",",
"as",
"well",
"as",
"in",
"the",
"production",
"of",
"free",
"ubiquitin",
"from",
"linear",
"poly-ubiquitin",
"chains",
"and",
"of",
"certain",
"ribosomal",
"proteins",
"from",
"ubiquitin",
"fusion",
"proteins",
"."
] | [
"these",
"result",
"suggest",
"that",
"ubp41",
"may",
"play",
"a",
"important",
"role",
"in",
"the",
"recycling",
"of",
"ubiquitin",
"by",
"hydrolysis",
"of",
"branch",
"poly-ubiquitin",
"chain",
"generate",
"by",
"the",
"action",
"of",
"26",
"s",
"proteasome",
"on",
"poly",
"ubiquitinated",
"protein",
"substrate",
",",
"as",
"well",
"as",
"in",
"the",
"production",
"of",
"free",
"ubiquitin",
"from",
"linear",
"poly-ubiquitin",
"chain",
"and",
"of",
"certain",
"ribosomal",
"protein",
"from",
"ubiquitin",
"fusion",
"protein",
"."
] | [
2,
35,
10,
20,
7,
13,
22,
2,
8,
7,
20,
2,
7,
20,
7,
20,
7,
20,
28,
7,
35,
28,
20,
2,
7,
20,
39,
7,
7,
20,
7,
8,
7,
35,
16,
26,
26,
20,
20,
2,
7,
20,
8,
7,
20,
8,
7,
35,
30,
20,
8,
8,
35,
20,
7,
7,
35,
15
] | [
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2
] |
[
"A",
"data",
"base",
"homology",
"search",
"revealed",
"that",
"the",
"predicted",
"ER1",
"amino",
"acid",
"sequence",
"contains",
"three",
"regions",
"of",
"similarity",
"to",
"the",
"rat",
"and",
"human",
"proteins",
"encoded",
"by",
"the",
"metastasis",
"associated",
"gene",
",",
"mta1",
",",
"and",
"two",
"regions",
"of",
"similarity",
"to",
"the",
"Caenorhabditis",
"elegans",
"sequence",
"that",
"is",
"similar",
"to",
"mta1",
"."
] | [
"a",
"datum",
"base",
"homology",
"search",
"reveal",
"that",
"the",
"predict",
"er1",
"amino",
"acid",
"sequence",
"contain",
"three",
"region",
"of",
"similarity",
"to",
"the",
"rat",
"and",
"human",
"protein",
"encode",
"by",
"the",
"metastasis",
"associate",
"gene",
",",
"mta1",
",",
"and",
"two",
"region",
"of",
"similarity",
"to",
"the",
"caenorhabditis",
"elegan",
"sequence",
"that",
"be",
"similar",
"to",
"mta1",
"."
] | [
2,
7,
7,
7,
7,
21,
20,
2,
28,
7,
7,
7,
7,
9,
39,
35,
20,
7,
24,
2,
7,
30,
8,
35,
28,
20,
2,
7,
28,
7,
16,
7,
16,
30,
39,
35,
20,
7,
24,
2,
7,
35,
7,
33,
9,
8,
24,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2
] |
[
"The",
"sequenced",
"cDNA",
"predicts",
"a",
"704-amino",
"acid",
"protein",
"80",
"%",
"identical",
"to",
"human",
"progelatinase",
"B."
] | [
"the",
"sequence",
"cdna",
"predict",
"a",
"704-amino",
"acid",
"protein",
"80",
"%",
"identical",
"to",
"human",
"progelatinase",
"B."
] | [
2,
28,
7,
9,
2,
8,
7,
7,
39,
7,
8,
24,
8,
7,
36
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1
] |
[
"Sequence",
"analysis",
"of",
"this",
"region",
"revealed",
"three",
"eight-bp",
"repetitive",
"elements",
",",
"the",
"deletion",
"of",
"which",
"restored",
"wild-type",
"levels",
"of",
"luciferase",
"activity",
"to",
"the",
"-916",
"-",
"bp",
"reporter",
"plasmid",
"."
] | [
"sequence",
"analysis",
"of",
"this",
"region",
"reveal",
"three",
"eight-bp",
"repetitive",
"element",
",",
"the",
"deletion",
"of",
"which",
"restore",
"wild-type",
"level",
"of",
"luciferase",
"activity",
"to",
"the",
"-916",
"-",
"bp",
"reporter",
"plasmid",
"."
] | [
7,
7,
20,
2,
7,
21,
39,
8,
8,
35,
16,
2,
7,
20,
33,
21,
8,
35,
20,
7,
7,
24,
2,
39,
40,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"This",
"is",
"the",
"first",
"study",
"in",
"which",
"mutation",
"screening",
"has",
"been",
"performed",
"for",
"both",
"the",
"EXT1",
"and",
"EXT2",
"genes",
"prior",
"to",
"any",
"linkage",
"analysis",
"."
] | [
"this",
"be",
"the",
"first",
"study",
"in",
"which",
"mutation",
"screening",
"have",
"be",
"perform",
"for",
"both",
"the",
"ext1",
"and",
"ext2",
"gene",
"prior",
"to",
"any",
"linkage",
"analysis",
"."
] | [
2,
9,
2,
8,
7,
20,
33,
7,
7,
9,
28,
28,
20,
30,
2,
7,
30,
7,
35,
26,
24,
2,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
1,
2,
2,
2,
2,
2,
2
] |
[
"Positron",
"emission",
"tomography",
"radioligands",
"for",
"dopamine",
"transporters",
"and",
"studies",
"in",
"human",
"and",
"nonhuman",
"primates",
"."
] | [
"Positron",
"emission",
"tomography",
"radioligand",
"for",
"dopamine",
"transporter",
"and",
"study",
"in",
"human",
"and",
"nonhuman",
"primate",
"."
] | [
36,
7,
7,
35,
20,
7,
35,
30,
35,
20,
8,
30,
8,
35,
15
] | [
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Attenuation",
"from",
"the",
"vit",
"A2",
"consensus",
"ERE",
"is",
"not",
"necessarily",
"dependent",
"on",
"DNA",
"binding",
"as",
"the",
"TR",
"alpha",
"DNA",
"binding",
"mutant",
"was",
"still",
"able",
"to",
"inhibit",
"E",
"dependent",
"transactivation",
"."
] | [
"attenuation",
"from",
"the",
"vit",
"a2",
"consensus",
"ere",
"be",
"not",
"necessarily",
"dependent",
"on",
"dna",
"binding",
"as",
"the",
"tr",
"alpha",
"dna",
"binding",
"mutant",
"be",
"still",
"able",
"to",
"inhibit",
"e",
"dependent",
"transactivation",
"."
] | [
7,
20,
2,
7,
7,
7,
7,
9,
26,
26,
8,
20,
7,
7,
20,
2,
7,
7,
7,
7,
7,
21,
26,
8,
24,
22,
7,
8,
7,
15
] | [
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Expression",
"from",
"this",
"element",
"is",
"regulated",
"by",
"a",
"heteromeric",
"protein",
"complex",
"containing",
"ubiquitous",
"(",
"i.e.",
"the",
"E2A-",
"and",
"HEB",
"encoded",
"proteins",
")",
"and",
"islet",
"enriched",
"members",
"of",
"the",
"bHLH",
"family",
"."
] | [
"expression",
"from",
"this",
"element",
"be",
"regulate",
"by",
"a",
"heteromeric",
"protein",
"complex",
"contain",
"ubiquitous",
"(",
"i.e.",
"the",
"e2a-_NN",
"and",
"heb",
"encode",
"protein",
")",
"and",
"islet",
"enriched",
"member",
"of",
"the",
"bhlh",
"family",
"."
] | [
7,
20,
2,
7,
9,
28,
20,
2,
8,
7,
7,
14,
8,
39,
11,
2,
7,
30,
7,
21,
35,
39,
30,
7,
8,
35,
20,
2,
8,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
[
"Thus",
",",
"the",
"CCAAT",
"box",
"also",
"has",
"tissue",
"specific",
"characteristics",
"that",
"assist",
"in",
"targeting",
"expression",
"of",
"the",
"alpha-subunit",
"gene",
"to",
"trophoblasts",
"."
] | [
"thus",
",",
"the",
"ccaat",
"box",
"also",
"have",
"tissue",
"specific",
"characteristic",
"that",
"assist",
"in",
"target",
"expression",
"of",
"the",
"alpha-subunit",
"gene",
"to",
"trophoblast",
"."
] | [
26,
16,
2,
7,
7,
26,
9,
7,
8,
35,
33,
10,
20,
14,
7,
20,
2,
7,
7,
24,
35,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2
] |
[
"U4",
"/",
"U6",
"snRNP",
"is",
"one",
"of",
"four",
"essential",
"small",
"nuclear",
"ribonucleoprotein",
"(",
"snRNP",
")",
"particles",
"(",
"U1",
",",
"U2",
",",
"U5",
"and",
"U4",
"/",
"U6",
")",
"present",
"in",
"the",
"spliceosome",
"."
] | [
"u4",
"/",
"u6",
"snrnp",
"be",
"one",
"of",
"four",
"essential",
"small",
"nuclear",
"ribonucleoprotein",
"(",
"snrnp",
")",
"particle",
"(",
"u1",
",",
"u2",
",",
"u5",
"and",
"u4",
"/",
"u6",
")",
"present",
"in",
"the",
"spliceosome",
"."
] | [
7,
40,
7,
7,
9,
39,
20,
39,
8,
8,
8,
7,
39,
7,
7,
35,
10,
7,
16,
7,
16,
7,
30,
7,
40,
7,
39,
8,
20,
2,
7,
15
] | [
0,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
2,
0,
2,
0,
2,
0,
2,
2,
2,
2,
2,
2
] |
[
"Hprp3p",
"is",
"a",
"77",
"kDa",
"protein",
",",
"which",
"is",
"homologous",
"to",
"the",
"Saccharomyces",
"cerevisiae",
"splicing",
"factor",
"Prp3p",
"."
] | [
"hprp3p",
"be",
"a",
"77",
"kda",
"protein",
",",
"which",
"be",
"homologous",
"to",
"the",
"saccharomyces",
"cerevisiae",
"splicing",
"factor",
"prp3p",
"."
] | [
7,
9,
2,
39,
7,
7,
16,
33,
9,
8,
24,
2,
11,
11,
7,
7,
7,
15
] | [
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
1,
2
] |
[
"The",
"growth",
"promoting",
"properties",
"of",
"the",
"retroviral",
"v-erbA",
"oncogene",
",",
"a",
"highly",
"mutated",
"version",
"of",
"the",
"chicken",
"thyroid",
"hormone",
"receptor",
"(",
"TR",
")",
"alpha",
",",
"have",
"so",
"far",
"exclusively",
"been",
"linked",
"to",
"dominant",
"repression",
"of",
"the",
"antimitogenic",
"roles",
"of",
"TR",
"and",
"retinoic",
"acid",
"receptors",
"."
] | [
"the",
"growth",
"promote",
"property",
"of",
"the",
"retroviral",
"v-erba",
"oncogene",
",",
"a",
"highly",
"mutate",
"version",
"of",
"the",
"chicken",
"thyroid",
"hormone",
"receptor",
"(",
"tr",
")",
"alpha",
",",
"have",
"so",
"far",
"exclusively",
"be",
"link",
"to",
"dominant",
"repression",
"of",
"the",
"antimitogenic",
"role",
"of",
"tr",
"and",
"retinoic",
"acid",
"receptor",
"."
] | [
2,
7,
14,
35,
20,
2,
8,
7,
7,
16,
2,
26,
28,
7,
20,
2,
7,
7,
7,
7,
39,
7,
7,
7,
16,
10,
26,
26,
26,
28,
28,
24,
8,
7,
20,
2,
8,
35,
20,
7,
30,
8,
7,
35,
15
] | [
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
1,
1,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
0,
1,
1,
2
] |
[
"We",
"cloned",
"a",
"complete",
"cDNA",
"(",
"2.9",
"kb",
")",
"for",
"HET",
"from",
"an",
"MCF-7",
"cDNA",
"library",
"."
] | [
"we",
"clone",
"a",
"complete",
"cdna",
"(",
"2.9",
"kb",
")",
"for",
"het",
"from",
"a",
"mcf-7",
"cdna",
"library",
"."
] | [
18,
21,
2,
8,
7,
7,
39,
7,
7,
20,
7,
20,
2,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2
] |
[
"Interferon",
"Regulatory",
"Factor",
"(",
"IRF",
")",
"-1",
"has",
"been",
"characterized",
"as",
"an",
"important",
"growth",
"regulatory",
"and",
"immunomodulatory",
"transcription",
"factor",
"."
] | [
"interferon",
"regulatory",
"factor",
"(",
"irf",
")",
"-1",
"have",
"be",
"characterize",
"as",
"a",
"important",
"growth",
"regulatory",
"and",
"immunomodulatory",
"transcription",
"factor",
"."
] | [
7,
8,
7,
7,
7,
39,
39,
9,
28,
28,
20,
2,
8,
7,
8,
30,
8,
7,
7,
15
] | [
0,
1,
1,
1,
1,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"The",
"genomic",
"structure",
"of",
"brk",
"consists",
"of",
"8",
"exons",
",",
"whose",
"boundaries",
"are",
"distinct",
"from",
"other",
"non",
"receptor",
"PTK",
"family",
"members",
",",
"again",
"indicating",
"a",
"structural",
"and",
"functional",
"divergence",
"."
] | [
"the",
"genomic",
"structure",
"of",
"brk",
"consist",
"of",
"8",
"exon",
",",
"whose",
"boundary",
"be",
"distinct",
"from",
"other",
"non",
"receptor",
"ptk",
"family",
"member",
",",
"again",
"indicate",
"a",
"structural",
"and",
"functional",
"divergence",
"."
] | [
2,
8,
7,
20,
7,
9,
20,
39,
35,
16,
23,
35,
10,
8,
20,
8,
8,
7,
7,
7,
35,
16,
26,
14,
2,
8,
30,
8,
7,
15
] | [
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"We",
"have",
"previously",
"reported",
"that",
"expression",
"of",
"a",
"tumour",
"derived",
"brk",
"cDNA",
"in",
"mouse",
"embryonic",
"fibroblasts",
"and",
"human",
"mammary",
"epithelial",
"cells",
"supports",
"anchorage",
"independent",
"growth",
",",
"and",
"in",
"the",
"latter",
"potentiates",
"the",
"mitogenic",
"response",
"to",
"epidermal",
"growth",
"factor",
"."
] | [
"we",
"have",
"previously",
"report",
"that",
"expression",
"of",
"a",
"tumour",
"derive",
"brk",
"cdna",
"in",
"mouse",
"embryonic",
"fibroblast",
"and",
"human",
"mammary",
"epithelial",
"cell",
"support",
"anchorage",
"independent",
"growth",
",",
"and",
"in",
"the",
"latter",
"potentiate",
"the",
"mitogenic",
"response",
"to",
"epidermal",
"growth",
"factor",
"."
] | [
18,
10,
26,
28,
20,
7,
20,
2,
7,
28,
7,
7,
20,
7,
8,
35,
30,
8,
8,
8,
35,
9,
7,
8,
7,
16,
30,
20,
2,
8,
9,
2,
8,
7,
24,
8,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2
] |
[
"Anti",
"hepatitis",
"A",
"virus",
"(",
"HAV",
")",
"titer",
"after",
"vaccination",
"was",
"measured",
"in",
"83",
"HIV",
"positive",
"and",
"39",
"HIV",
"negative",
"men",
"."
] | [
"anti",
"hepatitis",
"a",
"virus",
"(",
"hav",
")",
"titer",
"after",
"vaccination",
"be",
"measure",
"in",
"83",
"hiv",
"positive",
"and",
"39",
"hiv",
"negative",
"man",
"."
] | [
8,
7,
7,
7,
39,
7,
39,
7,
20,
7,
21,
28,
20,
39,
7,
8,
30,
39,
7,
8,
35,
15
] | [
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Surprisingly",
",",
"calf",
"thymus",
"CstF",
"contained",
"an",
"additional",
",",
"novel",
"form",
"of",
"the",
"64-kDa",
"subunit",
"with",
"a",
"molecular",
"mass",
"of",
"70",
"kDa",
"."
] | [
"surprisingly",
",",
"calf",
"thymus",
"cstf",
"contain",
"a",
"additional",
",",
"novel",
"form",
"of",
"the",
"64-kda",
"subunit",
"with",
"a",
"molecular",
"mass",
"of",
"70",
"kda",
"."
] | [
26,
16,
7,
7,
7,
21,
2,
8,
16,
8,
7,
20,
2,
8,
7,
20,
2,
8,
7,
20,
39,
7,
15
] | [
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Null",
"mutations",
"in",
"daf-3",
"suppress",
"mutations",
"in",
"genes",
"encoding",
"this",
"TGF-beta",
"signal",
",",
"its",
"receptors",
",",
"and",
"associated",
"Smad",
"signal",
"transduction",
"proteins",
".",
"daf-3",
"encodes",
"a",
"Smad",
"protein",
"that",
"is",
"most",
"closely",
"related",
"to",
"mammalian",
"DPC4",
",",
"and",
"is",
"expressed",
"throughout",
"development",
"in",
"many",
"of",
"the",
"tissues",
"that",
"are",
"remodeled",
"during",
"dauer",
"development",
"."
] | [
"null",
"mutation",
"in",
"daf-3",
"suppress",
"mutation",
"in",
"gene",
"encode",
"this",
"tgf-beta",
"signal",
",",
"its",
"receptor",
",",
"and",
"associate",
"smad",
"signal",
"transduction",
"protein",
".",
"daf-3",
"encode",
"a",
"smad",
"protein",
"that",
"be",
"most",
"closely",
"related",
"to",
"mammalian",
"dpc4",
",",
"and",
"be",
"express",
"throughout",
"development",
"in",
"many",
"of",
"the",
"tissue",
"that",
"be",
"remodel",
"during",
"dauer",
"development",
"."
] | [
8,
35,
20,
7,
10,
35,
20,
35,
14,
2,
7,
7,
16,
17,
35,
16,
30,
28,
7,
7,
7,
35,
15,
7,
9,
2,
7,
7,
33,
9,
31,
26,
8,
24,
8,
7,
16,
30,
9,
28,
20,
7,
20,
8,
20,
2,
35,
33,
10,
28,
20,
7,
7,
15
] | [
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2,
0,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"Our",
"results",
"favor",
"the",
"possibility",
"that",
"the",
"Drosophila",
"EGF",
"receptor",
"DER",
"/",
"Egfr",
"expressed",
"by",
"the",
"EMA",
"cells",
"functions",
"as",
"a",
"receptor",
"for",
"Vein",
"."
] | [
"we",
"result",
"favor",
"the",
"possibility",
"that",
"the",
"drosophila",
"egf",
"receptor",
"der",
"/",
"Egfr",
"express",
"by",
"the",
"ema",
"cell",
"function",
"as",
"a",
"receptor",
"for",
"vein",
"."
] | [
17,
35,
10,
2,
7,
20,
2,
11,
7,
7,
7,
40,
36,
28,
20,
2,
7,
35,
9,
20,
2,
7,
20,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
0,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2
] |
[
"PATIENTS",
"AND",
"METHODS",
":",
"In",
"807",
"consecutive",
"patients",
"from",
"the",
"Chilean",
"National",
"Registry",
"of",
"Acute",
"Myocardial",
"Infarction",
"we",
"analyzed",
"the",
"resolution",
"of",
"chest",
"pain",
"and",
"ST",
"segment",
"elevation",
"over",
"50",
"%",
"within",
"the",
"first",
"90",
"min",
",",
"abrupt",
"CK",
"rise",
"within",
"8",
"h",
"and",
"T",
"wave",
"inversion",
"in",
"infarct",
"related",
"EKG",
"leads",
"within",
"the",
"first",
"24",
"h",
"after",
"thrombolysis",
"."
] | [
"patient",
"and",
"method",
":",
"in",
"807",
"consecutive",
"patient",
"from",
"the",
"chilean",
"National",
"Registry",
"of",
"acute",
"myocardial",
"infarction",
"we",
"analyze",
"the",
"resolution",
"of",
"chest",
"pain",
"and",
"st",
"segment",
"elevation",
"over",
"50",
"%",
"within",
"the",
"first",
"90",
"min",
",",
"abrupt",
"CK",
"rise",
"within",
"8",
"h",
"and",
"t",
"wave",
"inversion",
"in",
"infarct",
"related",
"EKG",
"lead",
"within",
"the",
"first",
"24",
"h",
"after",
"thrombolysis",
"."
] | [
35,
30,
35,
40,
20,
39,
8,
35,
20,
2,
8,
36,
36,
20,
8,
8,
7,
18,
21,
2,
7,
20,
7,
7,
30,
8,
7,
7,
20,
39,
7,
20,
2,
8,
39,
7,
16,
8,
36,
7,
20,
39,
7,
30,
7,
7,
7,
20,
7,
8,
36,
9,
20,
2,
8,
39,
7,
20,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"It",
"has",
"been",
"proposed",
"that",
"the",
"parCBA",
"operon",
"encodes",
"a",
"plasmid",
"partitioning",
"system",
"(",
"M."
] | [
"it",
"have",
"be",
"propose",
"that",
"the",
"parcba",
"operon",
"encode",
"a",
"plasmid",
"partitioning",
"system",
"(",
"m."
] | [
18,
9,
28,
28,
20,
2,
7,
7,
9,
2,
7,
7,
7,
39,
7
] | [
2,
2,
2,
2,
2,
2,
0,
1,
2,
2,
2,
2,
2,
2,
2
] |
[
"Furthermore",
",",
"the",
"insertion",
"of",
"the",
"ColE1",
"cer",
"site",
"into",
"the",
"RK2",
"plasmid",
"deleted",
"for",
"the",
"par",
"region",
"failed",
"to",
"stabilize",
"the",
"plasmid",
"in",
"the",
"MC1061K",
"strain",
",",
"indicating",
"that",
"the",
"multimer",
"resolution",
"activity",
"encoded",
"by",
"parCBA",
"is",
"not",
"by",
"itself",
"responsible",
"for",
"the",
"stabilization",
"activity",
"observed",
"for",
"this",
"operon",
"."
] | [
"furthermore",
",",
"the",
"insertion",
"of",
"the",
"cole1",
"cer",
"site",
"into",
"the",
"rk2",
"plasmid",
"delete",
"for",
"the",
"par",
"region",
"fail",
"to",
"stabilize",
"the",
"plasmid",
"in",
"the",
"mc1061k",
"strain",
",",
"indicate",
"that",
"the",
"multimer",
"resolution",
"activity",
"encode",
"by",
"parcba",
"be",
"not",
"by",
"itself",
"responsible",
"for",
"the",
"stabilization",
"activity",
"observe",
"for",
"this",
"operon",
"."
] | [
26,
16,
2,
7,
20,
2,
7,
7,
7,
20,
2,
7,
7,
28,
20,
2,
8,
7,
21,
24,
22,
2,
7,
20,
2,
7,
7,
16,
14,
20,
2,
7,
7,
7,
28,
20,
7,
9,
26,
20,
18,
8,
20,
2,
7,
7,
28,
20,
2,
7,
15
] | [
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2
] |
[
"To",
"examine",
"the",
"basis",
"for",
"the",
"apparent",
"differences",
"in",
"postsegregational",
"killing",
"between",
"the",
"two",
"E.",
"coli",
"strains",
",",
"transformation",
"assays",
"were",
"carried",
"out",
"to",
"determine",
"the",
"relative",
"sensitivities",
"of",
"the",
"strains",
"to",
"the",
"ParE",
"toxin",
"protein",
"."
] | [
"to",
"examine",
"the",
"basis",
"for",
"the",
"apparent",
"difference",
"in",
"postsegregational",
"killing",
"between",
"the",
"two",
"e.",
"coli",
"strain",
",",
"transformation",
"assay",
"be",
"carry",
"out",
"to",
"determine",
"the",
"relative",
"sensitivity",
"of",
"the",
"strain",
"to",
"the",
"pare",
"toxin",
"protein",
"."
] | [
24,
22,
2,
7,
20,
2,
8,
35,
20,
8,
7,
20,
2,
39,
11,
11,
35,
16,
7,
35,
21,
28,
25,
24,
22,
2,
8,
35,
20,
2,
35,
24,
2,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2
] |
[
"Splice-junction",
"elements",
"and",
"intronic",
"sequences",
"regulate",
"alternative",
"splicing",
"of",
"the",
"Drosophila",
"myosin",
"heavy",
"chain",
"gene",
"transcript",
"."
] | [
"splice-junction",
"element",
"and",
"intronic",
"sequence",
"regulate",
"alternative",
"splicing",
"of",
"the",
"drosophila",
"myosin",
"heavy",
"chain",
"gene",
"transcript",
"."
] | [
8,
35,
30,
8,
35,
10,
8,
7,
20,
2,
11,
7,
8,
7,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
1,
2,
2
] |
[
"Nucleotide",
"sequence",
"analysis",
"of",
"R",
"has",
"revealed",
"similarities",
"to",
"the",
"R1",
"plasmid",
"found",
"in",
"some",
"South",
"American",
"maize",
"races",
"with",
"RU",
"cytoplasm",
",",
"to",
"the",
"M1",
"plasmid",
"found",
"in",
"one",
"source",
"of",
"Zea",
"luxurians",
"teosinte",
",",
"to",
"the",
"atp9",
"mitochondrial",
"gene",
"and",
"its",
"3",
"'",
"flanking",
"sequence",
",",
"and",
"also",
"to",
"a",
"region",
"3",
"'",
"to",
"the",
"orf221",
"gene",
"."
] | [
"nucleotide",
"sequence",
"analysis",
"of",
"r",
"have",
"reveal",
"similarity",
"to",
"the",
"r1",
"plasmid",
"find",
"in",
"some",
"south",
"american",
"maize",
"race",
"with",
"ru",
"cytoplasm",
",",
"to",
"the",
"m1",
"plasmid",
"find",
"in",
"one",
"source",
"of",
"Zea",
"luxurian",
"teosinte",
",",
"to",
"the",
"atp9",
"mitochondrial",
"gene",
"and",
"its",
"3",
"'",
"flanking",
"sequence",
",",
"and",
"also",
"to",
"a",
"region",
"3",
"'",
"to",
"the",
"orf221",
"gene",
"."
] | [
7,
7,
7,
20,
7,
9,
28,
35,
24,
2,
7,
7,
28,
20,
2,
8,
8,
7,
35,
20,
7,
7,
16,
24,
2,
7,
7,
28,
20,
39,
7,
20,
36,
9,
7,
16,
24,
2,
7,
8,
7,
30,
17,
39,
3,
8,
7,
16,
30,
26,
24,
2,
7,
39,
3,
24,
2,
7,
7,
15
] | [
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
1,
2
] |
Subsets and Splits