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JFK Assassination Records - 2018 Additional Documents Release | National Archives Have a question about JFK Assassination Records? Ask it on HistoryHub! The National Archives is releasing documents previously withheld in accordance with the JFK Assassination Records Collection Act. The vast majority of the Collection (88%) has been open in full and released to the public since the late 1990s. The records at issue are documents previously identified as JFK Assassination Records - 2018 Additional Documents Release The National Archives is releasing documents previously withheld in accordance with the JFK Assassination Records Collection Act.  The vast majority of the Collection (88%) has been open in full and released to the public since the late 1990s. The records at issue are documents previously identified as assassination records, but withheld in full or withheld in part.Learn more These releases include FBI, CIA, and other agency documents (both formerly withheld in part and formerly withheld in full) identified by the Assassination Records Review Board as assassination records. The releases to date are as follows: July 24, 2017: 3,810 documents (read press release ) October 26, 2017: 2,891 documents (read press release ) November 3, 2017: 676 documents (read press release ) November 9, 2017: 13,213 documents (read press release ) November 17, 2017: 10,744 documents (read press release ) December 15, 2017: 3,539 documents * (read press release ) April 26, 2018: 18,731 documents * (read press release ) * Note: There are instances where multiple record identification numbers are associated with the same pdf. This is due to the fact that the files were scanned in batches. Accessing the Release Files The table below displays metadata about all the released documents. You can alsodownload the spreadsheet as an Excel file(4.7MB). To view or download a specific document, follow the link in the "Doc Date" column. The files are sorted by NARA Release Date, with the most recent files appearing first. The previous withholding status (i.e., formerly withheld in part or formerly withheld in full) is identified in the “Formerly Withheld Status” column. JFK Table Row Num Record Num NARA Release Date Formerly Withheld Agency Doc Date Doc Type File Num To Name From Name Title Num Pages Originator Record Series Review Date Comments Pages Released Row Num Record Num NARA Release Date Formerly Withheld Agency Doc Date Doc Type File Num To Name From Name Title Num Pages Originator Record Series Review Date Comments Pages Released 36251 104-10072-10182 11/09/2017 In Part CIA 08/09/1973 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A COS COS COPY OF THE WATCHLIST PER REFERENCE. 29 CIA JFK 11/09/2017 JFK15 : F59 : 1993.08.02.19:23:48:810033 : 29 36252 104-10072-10228 11/09/2017 In Part CIA 05/11/1963 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A CHIEF, SAS COS COPIES OF SUBJECT CONTACT REPORTS DATED 11 MAY, 14 MAY, AND 15 MAY 1963. 13 CIA JFK 11/09/2017 JFK15 : F45 : 1993.08.03.19:37:02:870033 : 13 36253 104-10183-10342 11/09/2017 In Part CIA 04/15/1965 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A CHIEF, WH COS DISPATCH: FORMS FOR AMMUG/1. 1 CIA JFK 11/09/2017 JFK64-19 : F11 : 1998.04.22.20:35:30:420102 : 1 36254 104-10185-10010 11/09/2017 In Part CIA 10/13/1960 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A CHIEF, KUDOVE COS DISPATCH: ENVELOPE FOR JAMES N. RABNEY 2 CIA JFK 11/09/2017 JFK64-20 : F10 : 20040310-1056296 : 2 36255 104-10215-10014 11/09/2017 In Part CIA 12/02/1966 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A CHIEF, SB COS SUBJ: REDTOP VALENTIN VASILYEVICH BAKULIN. 1 CIA JFK 11/09/2017 JFK64-50 : F4 : 20040311-1057085 : 1 36256 104-10216-10025 11/09/2017 In Part CIA 09/15/1969 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A CHIEF, WHD COS DISPATCH: INFORMATION ON 13 OF MARZO MEMBERS FROM GUILLERMO GONZALES SEAVEDRA. 5 CIA JFK 11/09/2017 JFK64-51 : F10 : 20040315-1057838 : 5 36257 104-10216-10030 11/09/2017 In Part CIA 01/01/1964 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A DC/WH/SA COS DISPATCH: CUBAN ELECTRIC COMPANY. 1 CIA JFK 11/09/2017 JFK64-51 : F10 : 20040315-1057843 : 1 36258 104-10216-10031 11/09/2017 In Part CIA 03/04/1965 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A DC/WH/SA COS DISPATCH: AMLASH/1. 3 CIA JFK 11/09/2017 JFK64-51 : F10 : 20040315-1057844 : 3 36259 104-10216-10037 11/09/2017 In Part CIA 06/13/1965 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A D/CHIEF, WH,SA COS DISPATCH: TRANSMITTAL OF LETTER. 6 CIA JFK 11/09/2017 JFK64-51 : F10 : 20040315-1057846 : 6 36260 104-10216-10038 11/09/2017 In Part CIA 06/20/1967 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A D/CHIEF, WH/C COS DISPATCH: IDENTIFICATION OF COMMUNIST PARTY AND DSE MEMBERS. 2 CIA JFK 11/09/2017 JFK64-51 : F10 : 20040315-1057847 : 2 36261 104-10216-10058 11/09/2017 In Part CIA 07/10/1969 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A COS COS DISPATCH: SHOLOMO CLIKSBERG 2 CIA JFK 11/09/2017 JFK64-51 : F15 : 1998.04.25.14:19:17:623102 : 2 36262 104-10216-10104 11/09/2017 In Part CIA 11/01/1960 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A CHIEF, WHD COS DISPATCH-PBPRIME CITIZEN WITH EQUADOREAN GOVERNMENT CONNECTIONS. 1 CIA JFK 11/09/2017 JFK64-51 : F12 : 1998.04.29.13:10:08:340082 : 1 36263 104-10218-10006 11/09/2017 In Part CIA 08/15/1962 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A COS JMWAVE COS DISPATCH: INTERROGATION OF CUBAN REFUGEES. 9 CIA JFK 11/09/2017 JFK64-53 : F9 : 1998.04.25.17:24:30:233102 : 9 36264 104-10220-10022 11/09/2017 In Part CIA 08/08/1969 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A CHIEF, EUROPEAN DIV COS DISPATCH: NEWSPAPER ARTICLE CONCERNING RICHARD CASE NAGELL. 1 CIA JFK 11/09/2017 JFK64-55 : F7 : 20040316-1058567 : 1 36265 104-10087-10094 07/24/2017 In Part CIA 12/20/1963 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A DIRECTOR COS PLAN FOR PASSING INFORMATION TO W.C. CIA JFK 06/12/2017 JFK27 : F34 : 20040106-1030748 : 36266 104-10112-10160 07/24/2017 In Part CIA 08/09/1957 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A KING, J.C., C/WHD COS REQUEST FOR FIELD TRACES AND INVESTIGATION. CIA JFK 06/14/2017 JFK41 : F4 : 20040112-1033642 : 36267 104-10003-10085 04/26/2018 Redact 05/14/1964 [ PDF ] PAPER-TEXTUAL DOCUMENT 201-289248 C/WE COS SPANISH WEEKLY "SP" AND THE O'BRIEN ARTICLE, "LA POLICIA DE DALLAS MATO A KENNEDY" ("THE DALLAS POLICE KILLED KENNEDY") 8 CIA 03/12/2018 OSW9 : V37 : 1993.06.08.18:11:03:620000 : IDEN AID UPDATE TO CORRECT PAGE NUMBERS 36268 104-10003-10085 04/26/2018 Redact 05/14/1964 [ PDF ] PAPER-TEXTUAL DOCUMENT 201-289248 C/WE COS SPANISH WEEKLY "SP" AND THE O'BRIEN ARTICLE, "LA POLICIA DE DALLAS MATO A KENNEDY" ("THE DALLAS POLICE KILLED KENNEDY") 8 CIA 03/12/2018 OSW9 : V37 : 1993.06.08.18:11:03:620000 : IDEN AID UPDATE TO CORRECT PAGE NUMBERS 36269 104-10055-10045 04/26/2018 Redact CIA 11/23/1963 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A DIRECTOR COS CONDOLENCES OVER LOSS OF PRES KENNEDY AND OSWALD CALLS TO SOVIET EMBASSY IN MEXICO 2 CIA JFK 03/12/2018 JFK7 : F25 : 20031203-1019857 : 2 36270 104-10072-10182 04/26/2018 Redact CIA 08/09/1973 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A COS COS COPY OF THE WATCHLIST PER REFERENCE. 29 CIA JFK 03/12/2018 JFK15 : F59 : 1993.08.02.19:23:48:810033 : 29 36271 104-10072-10228 04/26/2018 Redact CIA 05/11/1963 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A CHIEF, SAS COS COPIES OF SUBJECT CONTACT REPORTS DATED 11 MAY, 14 MAY, AND 15 MAY 1963. 13 CIA JFK 03/12/2018 JFK15 : F45 : 1993.08.03.19:37:02:870033 : 13 36272 104-10183-10342 04/26/2018 Redact CIA 04/15/1965 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A CHIEF, WH COS DISPATCH: FORMS FOR AMMUG/1. 1 CIA JFK 03/16/2018 JFK64-19 : F11 : 1998.04.22.20:35:30:420102 : 1 36273 104-10185-10010 04/26/2018 Redact CIA 10/13/1960 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A CHIEF, KUDOVE COS DISPATCH: ENVELOPE FOR JAMES N. RABNEY 2 CIA JFK 03/16/2018 JFK64-20 : F10 : 20040310-1056296 : 2 36274 104-10215-10014 04/26/2018 Redact CIA 12/02/1966 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A CHIEF, SB COS SUBJ: REDTOP VALENTIN VASILYEVICH BAKULIN. 1 CIA JFK 03/16/2018 JFK64-50 : F4 : 20040311-1057085 : 1 36275 104-10216-10025 04/26/2018 Redact CIA 09/15/1969 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A CHIEF, WHD COS DISPATCH: INFORMATION ON 13 OF MARZO MEMBERS FROM GUILLERMO GONZALES SEAVEDRA. 5 CIA JFK 03/12/2018 JFK64-51 : F10 : 20040315-1057838 : 5 36276 104-10216-10030 04/26/2018 Redact CIA 01/01/1964 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A DC/WH/SA COS DISPATCH: CUBAN ELECTRIC COMPANY. 1 CIA JFK 03/12/2018 JFK64-51 : F10 : 20040315-1057843 : 1 36277 104-10216-10031 04/26/2018 Redact CIA 03/04/1965 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A DC/WH/SA COS DISPATCH: AMLASH/1. 3 CIA JFK 03/16/2018 JFK64-51 : F10 : 20040315-1057844 : 3 36278 104-10216-10037 04/26/2018 Redact CIA 06/13/1965 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A D/CHIEF, WH,SA COS DISPATCH: TRANSMITTAL OF LETTER. 6 CIA JFK 03/16/2018 JFK64-51 : F10 : 20040315-1057846 : 6 36279 104-10216-10038 04/26/2018 Redact CIA 06/20/1967 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A D/CHIEF, WH/C COS DISPATCH: IDENTIFICATION OF COMMUNIST PARTY AND DSE MEMBERS. 2 CIA JFK 03/16/2018 JFK64-51 : F10 : 20040315-1057847 : 2 36280 104-10216-10058 04/26/2018 Redact CIA 07/10/1969 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A COS COS DISPATCH: SHOLOMO CLIKSBERG 2 CIA JFK 03/12/2018 JFK64-51 : F15 : 1998.04.25.14:19:17:623102 : 2 36281 104-10216-10104 04/26/2018 Redact CIA 11/01/1960 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A CHIEF, WHD COS DISPATCH-PBPRIME CITIZEN WITH EQUADOREAN GOVERNMENT CONNECTIONS. 1 CIA JFK 03/16/2018 JFK64-51 : F12 : 1998.04.29.13:10:08:340082 : 1 36282 104-10218-10006 04/26/2018 Redact CIA 08/15/1962 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A COS JMWAVE COS DISPATCH: INTERROGATION OF CUBAN REFUGEES. 9 CIA JFK 03/16/2018 JFK64-53 : F9 : 1998.04.25.17:24:30:233102 : 9 36283 104-10220-10022 04/26/2018 Redact CIA 08/08/1969 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A CHIEF, EUROPEAN DIV COS DISPATCH: NEWSPAPER ARTICLE CONCERNING RICHARD CASE NAGELL. 1 CIA JFK 03/12/2018 JFK64-55 : F7 : 20040316-1058567 : 1 36284 104-10100-10237 11/09/2017 In Part CIA 10/18/1963 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A NONE CORPUS CHRISTI DELIVERY OF CARTRIDGES TO CORPUS CHRISTI 1 CIA JFK 11/09/2017 JFK33 : F5 : 20040108-1032333 : 1 36285 104-10100-10237 04/26/2018 Redact CIA 10/18/1963 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A NONE CORPUS CHRISTI DELIVERY OF CARTRIDGES TO CORPUS CHRISTI 1 CIA JFK 03/16/2018 JFK33 : F5 : 20040108-1032333 : 1 36286 180-10110-10103 10/26/2017 In Full HSCA 08/29/1978 [ PDF ] LETTER 127-JFK RHOADS, JAMES B. CORNWELL, GARY 2 HSCA SECURITY CLASSIFIED FILES 09/25/2017 Box 4. 3 36287 104-10180-10094 11/09/2017 In Part CIA 01/06/1965 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A COPS/WH (SA) MEMORANDUM FOR THE RECORD: SUBJECT - MANOLO RAY 1 CIA JFK 11/09/2017 JFK64-16 : F3 : 1998.04.04.18:37:34:140115 : 1 36288 104-10180-10094 04/26/2018 Redact CIA 01/06/1965 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A COPS/WH (SA) MEMORANDUM FOR THE RECORD: SUBJECT - MANOLO RAY 1 CIA JFK 03/12/2018 JFK64-16 : F3 : 1998.04.04.18:37:34:140115 : 1 36289 104-10225-10004 11/09/2017 In Part CIA 11/10/1964 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A HEADQUARTERS COPS, WH/SA/CI FITNESS REPORT ON JOSEPH S. PICCOLO 2 CIA JFK 11/09/2017 JFK64-60 : F2 : 20040316-1058692 : 2 36290 104-10225-10004 04/26/2018 Redact CIA 11/10/1964 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A HEADQUARTERS COPS, WH/SA/CI FITNESS REPORT ON JOSEPH S. PICCOLO 2 CIA JFK 03/16/2018 JFK64-60 : F2 : 20040316-1058692 : 2 36291 104-10165-10033 11/09/2017 In Part CIA 07/02/1959 [ PDF ] PAPER - TEXTUAL DOCUMENT 80T01357A SECRETARY OF STATE COPENHAGEN INCOMING TELEGRAM DOS: HAROLD CITRYNELL. 1 CIA JFK 11/09/2017 JFK64-4 : F8 : 1998.01.06.19:31:02:123102 : 1 36292 104-10165-10033 04/26/2018 Redact CIA 07/02/1959 [ PDF ] PAPER-TEXTUAL DOCUMENT 80T01357A SECRETARY OF DOS COPENHAGEN INCOMING TELEGRAM DOS: HAROLD CITRYNELL. 1 CIA JFK 03/12/2018 JFK64-4 : F8 : 1998.01.06.19:31:02:123102 : 1 36293 178-10003-10127 12/15/2017 In Part KISS/SCOW 12/01/1963 [ PDF ] MEMORANDUM 7602957 (2) DCI COOPER, CHESTER L. CONSIDERATIONS FOR US POLICY TOWARD CUBA AND LATIN AMERICA 6 CIA CHURCH COM. 11/30/2017 Attached to 1781000310109. Bad copy. Unmarked but contains classified information. 36294 178-10003-10158 12/15/2017 In Part KISS/SCOW 12/01/1963 [ PDF ] MEMORANDUM 7602957 (7) DCI COOPER, CHESTER L. CONSIDERATIONS FOR US POLICY TOWARD CUBA AND LATIN AMERICA 6 CIA CHURCH COM. 11/30/2017 Attached to 1781000310151. Bad copy. Unmarked but contains classified information. #4 and 4a on list. 36295 178-10003-10127 04/26/2018 Redact KISS/SCOW 12/01/1963 [ PDF ] PAPER-TEXTUAL DOCUMENT 7602957 (2) DCI COOPER, CHESTER L. CONSIDERATIONS FOR US POLICY TOWARD CUBA AND LATIN AMERICA 6 CIA CHURCH COM. 03/12/2018 Attached to 1781000310109. Bad copy. Unmarked but contains classified information. 36296 178-10003-10158 04/26/2018 Redact KISS/SCOW 12/01/1963 [ PDF ] PAPER-TEXTUAL DOCUMENT 7602957 (7) DCI COOPER, CHESTER L. CONSIDERATIONS FOR US POLICY TOWARD CUBA AND LATIN AMERICA 6 CIA CHURCH COM. 03/12/2018 Attached to 1781000310151. Bad copy. Unmarked but contains classified information. #4 and 4a on list. 36297 124-10194-10251 11/17/2017 In Part FBI 07/25/1963 [ PDF ] PAPER, TEXTUAL DOCUMENT 92-3182-807 DIRECTOR, FBI COOK, ROBERT A. 21 FBI HQ 11/17/2017 36298 124-10194-10314 11/17/2017 In Part FBI 11/29/1963 [ PDF ] PAPER, TEXTUAL DOCUMENT 92-3182-869 DIRECTOR, FBI COOK, ROBERT A. 19 FBI HQ 11/17/2017 36299 124-10194-10338 11/17/2017 In Part FBI 01/22/1964 [ PDF ] PAPER, TEXTUAL DOCUMENT 92-3182-893 DIRECTOR, FBI COOK, ROBERT A. 15 FBI HQ 11/17/2017 36300 124-10199-10112 11/17/2017 In Part FBI 03/10/1961 [ PDF ] PAPER, TEXTUAL DOCUMENT 92-3182-160 DIRECTOR, FBI COOK, ROBERT A. 37 FBI HQ 11/17/2017
https://www.archives.gov/research/jfk/release?order=From%20Name&page=725&sort=desc
Compressive CSIT estimation for multi-user massive MIMO with autonomous adaptation of pilot and feedback | Request PDF Request PDF | On May 1, 2016, Feibai Zhu and others published Compressive CSIT estimation for multi-user massive MIMO with autonomous adaptation of pilot and feedback | Find, read and cite all the research you need on ResearchGate Conference Paper Compressive CSIT estimation for multi-user massive MIMO with autonomous adaptation of pilot and feedback May 2016 DOI: 10.1109/ICC.2016.7510946 Conference: ICC 2016 - 2016 IEEE International Conference on Communications Authors: . In this paper, we focus on a downlink training framework for FDD massive MIMO systems. ... ... In addition, it is shown from many experimental studies of massive MIMO channels that the channel matrices are sparse in the angular domain due to limited scattering around the BTS [10]- [14]. Therefore, such hidden sparsity structure has been utilized in [6]- [9] by applying compressed sensing techniques to estimate CSIT with significantly reduced training overhead. ... ... However, most of the sparsity-inspired approaches assume that receivers perfectly feed back the analog received signal to the BTS [7]- [9] . One possible implementation is to quantize the received signal and feed back the quantized symbols to the BTS. ... Sparse Channel Estimation for Massive MIMO with 1-Bit Feedback Per Dimension Conference Paper In massive multiple-input multiple-output (MIMO) systems, acquisition of the channel state information at the transmitter side (CSIT) is crucial. In this paper, a practical CSIT estimation scheme is proposed for frequency division duplexing (FDD) massive MIMO systems. Specifically, each received pilot symbol is first quantized to one bit per dimension at the receiver side and then the quantized bits are fed back to the transmitter. A joint one-bit compressed sensing algorithm is implemented at the transmitter to recover the channel matrices. The algorithm leverages the hidden joint sparsity structure in the user channel matrices to minimize the training and feedback overhead, which is considered to be a major challenge for FDD systems. Moreover, the one-bit compressed sensing algorithm accurately recovers the channel directions for beamforming. The one-bit feedback mechanism can be implemented in practical systems using the uplink control channel. Simulation results show that the proposed scheme nearly achieves the maximum output signal-to-noise-ratio for beamforming based on the estimated CSIT. ... In current wireless standards based on Orthogonal Frequency Division Multiplexing (OFDM), there is little flexibility for adaptive signaling, such as support for multiple classes of adaptive waveform parameters such as subcarrier spacing, OFDM symbol duration, frame structures and adaptive control channel overhead based on different operating conditions. In the evolution from 4G to 5G, there is considerable interest in the research community to adopt multicarrier waveforms with adaptive transmission parameters at the physical layer in order to enhance the spectral efficiency [4], [5] , [6]. Although not all control channels can be eliminated to reduce system overhead, one class of control signals whose overhead can be controlled are 'pilots' or 'reference signals'. ... ... Zhu et. al [5] Adaptive Pilot Patterns for CA-OFDM Systems in Nonstationary Wireless Channels IEEE T VEH TECHNOL Raghunandan M Rao In this paper, we investigate the performance gains of adapting pilot spacing and power for Carrier Aggregation (CA)-OFDM systems in nonstationary wireless channels. In current multi-band CA-OFDM wireless networks, all component carriers use the same pilot density, which is designed for poor channel environments. This leads to unnecessary pilot overhead in good channel conditions and performance degradation in the worst channel conditions. We propose adaptation of pilot spacing and power using a codebook-based approach, where the transmitter and receiver exchange information about the fading characteristics of the channel over a short period of time, which are stored as entries in a channel profile codebook. We present a heuristic algorithm that maximizes the achievable rate by finding the optimal pilot spacing and power, from a set of candidate pilot configurations. We also analyze the computational complexity of our proposed algorithm and the feedback overhead. We describe methods to minimize the computation and feedback requirements for our algorithm in multi-band CA scenarios and present simulation results in typical terrestrial and air-to-ground/air-to-air nonstationary channels. Our results show that significant performance gains can be achieved when adopting adaptive pilot spacing and power allocation in nonstationary channels. We also discuss important practical considerations and provide guidelines to implement adaptive pilot spacing in CA-OFDM systems. Equipping base stations (BSs) with very large antenna arrays is a promising way to increase the spectral and energy efficiency of mobile communication systems without the need for new cell sites. However, the prominently theoretical works on this topic are based on several crucial assumptions about the wireless channel which have not been sufficiently validated by measurements. In this paper, we report on an outdoor measurement campaign with a scalable virtual antenna array consisting of up to 112 elements. The large amount of acquired data allows us to study several important aspects of large-scale MIMO systems. For example, we partially confirm the theoretical results based on uncorrelated channels which predict that the channels at different positions become more and more orthogonal as the number of antennas grows. However, for the measured channels, the marginal gain of an additional antenna quickly diminishes. Nevertheless, our results indicate that most of the theoretical benefits of large-scale MIMO could be realized also over the measured channels. Article Full-text available Jul 2010 P IEEE Waheed U. Bajwa Jarvis Haupt Akbar M Sayeed Robert Nowak High-rate data communication over a multipath wireless channel often requires that the channel response be known at the receiver. Training-based methods, which probe the channel in time, frequency, and space with known signals and reconstruct the channel response from the output signals, are most commonly used to accomplish this task. Traditional training-based channel estimation methods, typically comprising linear reconstruction techniques, are known to be optimal for rich multipath channels. However, physical arguments and growing experimental evidence suggest that many wireless channels encountered in practice tend to exhibit a sparse multipath structure that gets pronounced as the signal space dimension gets large (e.g., due to large bandwidth or large number of antennas). In this paper, we formalize the notion of multipath sparsity and present a new approach to estimating sparse (or effectively sparse) multipath channels that is based on some of the recent advances in the theory of compressed sensing. In particular, it is shown in the paper that the proposed approach, which is termed as compressed channel sensing (CCS), can potentially achieve a target reconstruction error using far less energy and, in many instances, latency and bandwidth than that dictated by the traditional least-squares-based training methods. Linear Pre-Coding Performance in Measured Very-Large MIMO Channels Conference Paper Full-text available Sep 2011 Veh Tech Conf Xiang Gao Ove Edfors Fredrik Rusek Fredrik Tufvesson Wireless communication using very-large multiple-input multiple-output (MIMO) antennas is a new research field, where base stations are equipped with a very large number of antennas as compared to previously considered systems. In theory, as the number of antennas increases, propagation properties that were random before start to become deterministic. Theoretical investigations with independent identically distributed (i.i.d.) complex Gaussian (Rayleigh fading) channels and unlimited number of antennas have been done, but in practice we need to know what benefits we can get from very large, but limited, number of antenna elements in realistic propagation environments. In this study we evaluate properties of measured residential-area channels, where the base station is equipped with 128 antenna ports. An important property to consider is the orthogonality between channels to different users, since this property tells us how advanced multi-user MIMO (MU-MIMO) pre-coding schemes we need in the downlink. We show that orthogonality improves with increasing number of antennas, but for two single-antenna users there is very little improvement beyond 20 antennas. We also evaluate sum-rate performance for two linear pre-coding schemes, zero-forcing (ZF) and minimum mean squared error (MMSE), as a function of the number of base station antennas. Already at 20 base station antennas these linear pre-coding schemes reach 98% of the optimal dirty-paper coding (DPC) capacity for the measured channels. Message Passing Algorithms for Compressed Sensing Article Full-text available Nov 2009 P NATL ACAD SCI USA David Donoho Arian Maleki Andrea Montanari Compressed sensing aims to undersample certain high-dimensional signals yet accurately reconstruct them by exploiting signal characteristics. Accurate reconstruction is possible when the object to be recovered is sufficiently sparse in a known basis. Currently, the best known sparsity-undersampling tradeoff is achieved when reconstructing by convex optimization, which is expensive in important large-scale applications. Fast iterative thresholding algorithms have been intensively studied as alternatives to convex optimization for large-scale problems. Unfortunately known fast algorithms offer substantially worse sparsity-undersampling tradeoffs than convex optimization. We introduce a simple costless modification to iterative thresholding making the sparsity-undersampling tradeoff of the new algorithms equivalent to that of the corresponding convex optimization procedures. The new iterative-thresholding algorithms are inspired by belief propagation in graphical models. Our empirical measurements of the sparsity-undersampling tradeoff for the new algorithms agree with theoretical calculations. We show that a state evolution formalism correctly derives the true sparsity-undersampling tradeoff. There is a surprising agreement between earlier calculations based on random convex polytopes and this apparently very different theoretical formalism. A Convergent Iterative Restricted Complexity Control Design Scheme Conference Paper Full-text available Jan 1995 Håkan Hjalmarsson Svante Gunnarsson Michel Gevers In this contribution we propose an optimization approach to the design of a restricted complexity controller. The design criterion is of LQG type containing two terms. The first term is the quadratic norm of the error between the output of the true closed loop and a desired response. The second term is the quadratic norm of the input signal. It is shown that the minimization of this criterion does not require a model of the system. Closed loop experimental data can be used instead. The result is an iterative scheme of closed loop experiments and controller updates which converges to a local minimum of the design criterion under the condition of bounded signals Full-text available Nov 2002 IEEE T SIGNAL PROCES Akbar M Sayeed Accurate and tractable channel modeling is critical to realizing the full potential of antenna arrays in wireless communications. Current approaches represent two extremes: idealized statistical models representing a rich scattering environment and parameterized physical models that describe realistic scattering environments via the angles and gains associated with different propagation paths. However, simple rules that capture the effects of scattering characteristics on channel capacity and diversity are difficult to infer from existing models. We propose an intermediate virtual channel representation that captures the essence of physical modeling and provides a simple geometric interpretation of the scattering environment. The virtual representation corresponds to a fixed coordinate transformation via spatial basis functions defined by fixed virtual angles. We show that in an uncorrelated scattering environment, the elements of the channel matrix form a segment of a stationary process and that the virtual channel coefficients are approximately uncorrelated samples of the underlying spectral representation. For any scattering environment, the virtual channel matrix clearly reveals the two key factors affecting capacity: the number of parallel channels and the level of diversity. The concepts of spatial zooming and aliasing are introduced to provide a transparent interpretation of the effect of antenna spacing on channel statistics and capacity. Numerical results are presented to illustrate various aspects of the virtual framework. Correlation analysis based on MIMO channel measurements in an indoor environment Article Full-text available Jul 2003 IEEE J SEL AREA COMM Persefoni Kyritsi D.C. Cox Reinaldo A. Valenzuela Peter Wolniansky Multiple-input-multiple-output (MIMO) systems have the potential to achieve very high capacities, depending on the propagation environment. Capacity increases as signal correlation decreases. We present the measurements of a MIMO system under strong and weak line-of-sight conditions. The system capacity decreases as the distance from the transmitter increases. Indeed the transmitter correlation increases as the distance increases. The receiver correlation is lower than the transmitter correlation under both propagation conditions. On the bang-bang control problem Article Mar 1955 Richard Bellman Irving Glicksberg Oliver Gross Let S be a physical system whose state at any time is described by an n-dimensional vector x(t), where x(t) is determined by a linear differential equation Z = Az, with A a constant matrix. Application of external influences will yield an inhomogeneous equation, Z = Az + f, where f, the 'forcing term', represents the control. A problem of some importance in the theory of control circuits is that of choosing f so as to reduce z to 0 in minimum time. If f is restricted to belong to the class of vectors whose i(th) components can assume only the values =b sub i, the control is said to be of the 'bang-bang' type. The case where all the solutions of Z = Az approach zero as t approaches infinity is considered. Fundamentals of Wireless Communication (Hardcover) Article May 2005 David Tse Pramod Viswanath The past decade has seen many advances in physical layer wireless communication theory and their implementation in wireless systems. This textbook takes a unified view of the fundamentals of wireless communication and explains the web of concepts underpinning these advances at a level accessible to an audience with a basic background in probability and digital communication. Topics covered include MIMO (multi-input, multi-output) communication, space-time coding, opportunistic communication, OFDM and CDMA. The concepts are illustrated using many examples from real wireless systems such as GSM, IS-95 (CDMA), IS-856 (1 x EV-DO), Flash OFDM and UWB (ultra-wideband). Particular emphasis is placed on the interplay between concepts and their implementation in real systems. An abundant supply of exercises and figures reinforce the material in the text. This book is intended for use on graduate courses in electrical and computer engineering and will also be of great interest to practising engineers. Distributed compressive CSIT estimation and feedback for FDD multi-user massive MIMO systems Article Jun 2014 IEEE T SIGNAL PROCES Xiongbin Rao Vincent Lau To fully utilize the spatial multiplexing gains or array gains of massive MIMO, the channel state information must be obtained at the transmitter side (CSIT). However, conventional CSIT estimation approaches are not suitable for FDD massive MIMO systems because of the overwhelming training and feedback overhead. In this paper, we consider multi-user massive MIMO systems and deploy the compressive sensing (CS) technique to reduce the training as well as the feedback overhead in the CSIT estimation. The multi-user massive MIMO systems exhibits a hidden joint sparsity structure in the user channel matrices due to the shared local scatterers in the physical propagation environment. As such, instead of naively applying the conventional CS to the CSIT estimation, we propose a distributed compressive CSIT estimation scheme so that the compressed measurements are observed at the users locally, while the CSIT recovery is performed at the base station jointly. A joint orthogonal matching pursuit recovery algorithm is proposed to perform the CSIT recovery, with the capability of exploiting the hidden joint sparsity in the user channel matrices. We analyze the obtained CSIT quality in terms of the normalized mean absolute error, and through the closed-form expressions, we obtain simple insights into how the joint channel sparsity can be exploited to improve the CSIT recovery performance. Closed-Loop Autonomous Pilot and Compressive CSIT Feedback Resource Adaptation in Multi-user FDD Mas... October 2016 · IEEE Transactions on Signal Processing Acquisition of accurate channel state information (CSI) at the transmitter (CSIT) is a major challenge of deploying frequency-division duplexing (FDD) massive MIMO systems. Although compressive sensing (CS) based CSIT estimation approaches have been proposed to reduce the pilot training overhead for massive MIMO systems, the existing schemes cannot properly dimension the minimum required pilot ... [Show full abstract] symbols to estimate the CSIT of all users at the required CSIT quality, because of the loose bounds on the required number of measurements for successful CS recovery and the unknown sparsity levels of user channels. In this paper, we propose a robust closed-loop pilot and CSIT feedback resource adaptation framework which not only exploits the joint sparsity of the multi-user (MU) massive MIMO channels to improve the CSIT estimation performance, but also has the built-in learning capability to adapt to the minimum pilot and feedback resources needed for successful CSIT recovery under unknown and time-varying channel sparsity levels. We establish the convergence of the proposed closed-loop adaptation algorithm under certain conditions. Simulations show that the proposed framework has substantial performance gain over conventional schemes with a fixed number of pilots and is very robust to dynamic sparsity as well as model mismatch. Nailed It: Autonomous Roofing with a Nailgun-Equipped Octocopter View Video Presentation: https://doi.org/10.2514/6.2021-3211.vid This paper presents the first demonstration of autonomous roofing with a multicopter. A DJI S1000 octocopter equipped with an off-the-shelf nailgun was used to secure shingles on an adjustable-slope roof mock-up. The nailgun was modified to allow safe, autonomous triggering from the multicopter through tooltip compression feedback. ... [Show full abstract] A mount was designed to adjust the angle to match representative roof slopes. An open-source octocopter autopilot facilitated controller adaptation for the roofing application. An autonomous nailing sequence was developed using smooth trajectories designed to apply prescribed contact forces for reliable nail deployment. Experimental results showed that the system is capable of nailing within a required three centimeter vertical gap on the shingle at 30 degree roof slope. Extensions to achieve a complete autonomous roofing system are discussed as future work.
https://www.researchgate.net/publication/305675776_Compressive_CSIT_estimation_for_multi-user_massive_MIMO_with_autonomous_adaptation_of_pilot_and_feedback
Materials | Free Full-Text | Sulfur-Deficient Porous SnS2−x Microflowers as Superior Anode for Alkaline Ion Batteries SnS2 as a high energy anode material has attracted extensive research interest recently. However, the fast capacity decay and low rate performance in alkaline-ion batteries associated with repeated volume variation and low electrical conductivity plague them from practical application. Herein, we propose a facile method to solve this problem by synthesizing porous SnS2 microflowers with in-situ formed sulfur vacancies. The flexible porous nanosheets in the three-dimensional flower-like nanostructure provide facile strain relaxation to avoid stress concentration during the volume changes. Rich sulfur vacancies and porous structure enable the fast and efficient electron transport. The porous SnS2−x microflowers exhibit outstanding performance for lithium ion battery in terms of high capacity (1375 mAh g−1 at 100 mA g−1) and outstanding rate capability (827 mA h g−1 at high rate of 2 A g−1). For sodium ion battery, a high capacity (~522 mAh g−1) can be achieved at 5 A g−1 after 200 cycles for SnS2−x microflowers. The rational design in nanostructures, as well as the chemical compositions, might create new opportunities in designing the new architecture for highly efficient energy storage devices. Sulfur-Deficient Porous SnS 2−x Microflowers as Superior Anode for Alkaline Ion Batteries by Lei Zhang 1,2 , Bin Yao 2 , Congli Sun 1,* , Shanshan Shi 3 , Wangwang Xu 4 and Kangning Zhao 1,3,* 1 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China 2 3 College of Sciences & Institute for Sustainable Energy, Shanghai University, Shanghai 200444, China 4 Department of Mechanical and Industrial Engineering, Louisiana State University Baton Rouge, LA 70830, USA * Authors to whom correspondence should be addressed. Materials 2020 , 13 (2), 443; https://doi.org/10.3390/ma13020443 Received: 9 December 2019 / Revised: 3 January 2020 / Accepted: 14 January 2020 / Published: 17 January 2020 (This article belongs to the Section Energy Materials ) Abstract : SnS 2 as a high energy anode material has attracted extensive research interest recently. However, the fast capacity decay and low rate performance in alkaline-ion batteries associated with repeated volume variation and low electrical conductivity plague them from practical application. Herein, we propose a facile method to solve this problem by synthesizing porous SnS 2 microflowers with in-situ formed sulfur vacancies. The flexible porous nanosheets in the three-dimensional flower-like nanostructure provide facile strain relaxation to avoid stress concentration during the volume changes. Rich sulfur vacancies and porous structure enable the fast and efficient electron transport. The porous SnS 2−x at 100 mA g −1 ) and outstanding rate capability (827 mA h g −1 at high rate of 2 A g −1 ). For sodium ion battery, a high capacity (~522 mAh g −1 ) can be achieved at 5 A g −1 after 200 cycles for SnS 2−x microflowers. The rational design in nanostructures, as well as the chemical compositions, might create new opportunities in designing the new architecture for highly efficient energy storage devices. Keywords: lithium-ion battery ; porous nanosheet ; SnS 2 ; sulfur vacancy ; sodium-ion battery 1. Introduction The energy crisis brings about a challenge to human life and sustainable and clean energy storage devices play a key role to overcome these issues [ 1 ]. Lithium-ion batteries (LIBs) dominate the commercial portable energy storage devices, including cell phones. However, their low energy density hinders them from some emerging applications such as electric vehicle (EVs) [ 2 ]. In commercial LIBs, graphite is commercialized as an anode electrode and its limited theoretical capacity (372 mAh g −1 ) is far from the increasing demand [ 3 , 4 , 5 ]. Thus, high capacity anode development becomes crucial. Additionally, sodium-ion batteries (SIBs) have become promising alternative energy storage devices for large-scale applications due to the low cost and earth-abundance of sodium resources [ 6 ]. Nevertheless, due to the narrow lattice spacing of graphite and large radius of the Na + ions (0.97 Å), graphite usually exhibits sluggish kinetics for Na + ions and inferior performance as anode for SIBs [ 7 , 8 , 9 ]. Therefore, development of high energy and long life anode materials is urgently needed. Tin-based materials have received more and more research interest due to the high theoretical capacity and low charging/discharging potential platform [ 10 , 11 ]. Despite the high lithium/sodium storage capability, the fast capacity loss during repetitive huge volume expansion–contraction remains a major challenge to tin-based materials [ 12 ]. As a typical layered metal dichalcogenide material, SnS 2 is a typical two-dimensional layered structure and the large interlayer spacing could not only store the intercalated Li + or Na + ions but also release the stress induced by volume change [ 13 ]. However, as a ceramic semiconductor, tin disulfide suffers from low electronic conductivities [ 14 , 15 , 16 , 17 , 18 , 19 ]. Different highly conductive materials have been added to composite with SnS 2 , such as grapheme [ 20 , 21 , 22 , 23 , 24 , 25 ], PPy [ 18 ], and so on [ 26 , 27 ]. Another method is to decrease the feature size of SnS 2 and build nanostructures in order to reduce the length of ion transportation. Sulfur vacancies have been recently reported to increase the electrical conductivity of SnS 2 [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Thus, rational design of hierarchical structures with sulfur vacancies would improve the electrochemical performance of SnS 2 . Herein, we designed three-dimensional hierarchical porous SnS 2−x microflowers with interconnected porous nanosheets as anode for LIBs and SIBs. The SnS 2−x microflowers exhibit excellent electrochemical properties for LIBs and SIBs. The excellent electrochemical performance of SnS 2−x microflowers can be attributed to the porous structure of SnS 2−x nanosheets, which provide more accessible active sites and shorten the length for alkaline ion diffusion and rich sulfur vacancy. The rich sulfur vacancy would increase the electric conductivity and the formation of porous structure would lead to the facile strain relaxation during battery cycling. In this way, the porous SnS 2−x microflowers exhibit promising performance in both lithium and sodium ion storage. 2. Results and Discussion SnS 2−x microflowers were synthesized via a hydrothermal reaction and this was followed by annealing process ( Figure 1 ). After the hydrothermal reaction, SnS 2 microflowers were formed. The microflowers are composed of interconnected flexible thin SnS 2 nanosheets. The additional annealing process not only increases the crystallinity of the SnS 2 microflowers but also introduces sulfur vacancies in the SnS 2−x nanosheets. XRD spectra were carried out to investigate the crystal structure of the products ( Figure 2 a). All the diffraction peaks of the SnS 2 , SnS 2 -400, and SnS 2 -450 are well indexed to the hexagonal structure of SnS 2 (JCPDS No.01-089-2358). All of these well-defined identified diffraction peaks at 15.0°, 28.2°, 32.1°, and 41.9° can be well assigned to (001), (100), (011), and (012) planes of hexagonal SnS 2 , respectively. When the annealing temperature was increased to 500 °C, the impurity phase Sn 4 S 3 (Orthorhombic, JCPDS No.00-030-1379) is generated accompanying with the main phase SnS 2 . Furthermore, the morphologies of the as-prepared samples were characterized by SEM and TEM. The SnS 2 microflowers are composed of thin and smooth nanosheets ( Figure 2 b). The SEM morphology of microflowers kept unchanged for SnS 2−x -400 and SnS 2−x -450 ( Figure 2 c and Figure S1 ), while it became a mixture of microflowers and bulks for SnS 2−x -500 ( Figure S2 ). The energy dispersive spectrometer (EDS) mapping confirms the homogeneous distribution of Sn and S elements in the entire sample of SnS 2−x microflowers ( Figure S2 ). In order to further identify the pore size and crystallographic structure of the SnS 2−x microflowers, scanning transmission electron microscopy (STEM) and high resolution scanning transmission electron microscopy (HRSTEM) were further carried out. There are no obvious pores observed on SnS 2 nanosheets ( Figure S3 ). Pores become distinct on the nanoflakes of SnS 2−x -400 and SnS 2−x -450, while the pore size of the SnS 2−x -450 nanosheets is larger than that in SnS 2−x -400 nanosheets ( Figure 2 c, Figure S3 ). However, further increasing the annealing temperature, no pores were observed on SnS 2−x -500 due to the phase evolution to Sn 3 S 4 ( Figure S3 ). HRTEM image in Figure 2 d shows that the pore size is in the range of 2–20 nm. The side view of the nanosheet suggests that the nanosheet is composed of 15 layers ( Figure 2 e). The HRSTEM image reveals the typical 2H phase of SnS 2 and no obvious lattice shift was observed, suggesting that the formation of pores does not affect the crystal structure. In order to investigate the contents of sulfur vacancies in SnS 2−x samples, thermogravimetric (TG) analysis was carried out in the air ( Figure 3 a,b). For SnS 2 microflowers, the total weight loss is 17.6%, while the total weight loss of SnS 2−x microflowers is only 13.7%. During the annealing in air, the SnS 2 is oxided to SnO 2 . The much lower weight loss of SnS 2−x microflowers corresponds to the rich sulfur vacancies in SnS 2−x microflowers, which is formed during the annealing process under sulfur-deficient environment. To further study the formation of sulfur vacancies in SnS 2−x microflowers during annealing process, XPS measurements were conducted on the samples before and after the annealing ( Figure 3 ). In Figure 3 c–f, both Sn 3d and S 2p peaks in XPS spectra were shifted to lower binding energies after annealing, suggesting the formation of low-valance Sn 2+ and sulfur vacancies [ 32 ]. In addition, the Sn 3d spectrum shown in Figure 3 c can be further deconvoluted into four peaks. The two dominating peaks at 495.3 eV and 487.0 eV correspond to Sn 4+ , while the two small peaks at 485.8 eV and 494 eV correspond to Sn 2+ , indicating the coexistence of Sn 4+ and Sn 2+ in SnS 2−x microflowers [ 35 ]. However, there are only two peaks ( Figure 3 e) for the SnS 2 microflowers (495.3 eV, 487.0 eV), suggesting the presence of Sn 4+ in the SnS 2 microflowers. The N 2 adsorption–desorption isotherms of SnS 2 microflowers and SnS 2−x microflowers are shown in Figure S4 . The specific surface area of porous SnS 2−x -450 microflowers is 20.1 m 2 g –1 , which is much higher than SnS 2 microflowers (5.8 m 2 g −1 ), SnS 2−x -400 (9.8 m 2 g −1 ), and SnS 2−x -500 (6.6 m 2 g −1 ). The higher surface area is attributed to a greater number of pores, as evidenced by the STEM images in Figure 2 d. Sulfur vacancies are believed to stabilize this material for alkaline ion storage. Cyclic voltammetry (CV) of SnS 2−x microflower sample was measured at 0.1 mV s −1 in the potential range of 0.01–3 V vs. Li/Li + , which is shown in Figures S5 and S6 . In the initial sweeping process, the CV curves show two broad peaks located at ~1.4 V and ~0.2 V, ascribing to the conversion reaction of SnS 2 into metallic Sn and Li 2 S (reaction 1) and the alloying reaction of Li-Sn alloy (reaction 2), respectively. Cycling performances of the samples are one of the most important parameters for batteries and are evaluated by a galvanostatic charging/discharging test as in Figure 4 a. SnS 2−x -450 exhibits much better cycling stability than those of SnS 2 , SnS 2 -400, and SnS 2 -500. At 100 mA g −1 (corresponding to 0.06C), the initial discharging capacity of SnS 2−x -450 is 1375 mA h g −1 , surpassing those of SnS 2 (1311 mAh g −1 ), SnS 2 -400 (1128 mAh g −1 ), and SnS 2 -500 (1306 mAh g −1 ). The 50th capacity of SnS 2−x -450 is 865 mA h g −1 corresponding to a capacity retention of 62.9%, which is much higher than that of SnS 2 (362 mA h g −1 , 27.8%), SnS 2−x -400 (643 mA h g −1 , 57.0%), and SnS 2−x -500 (575 mA h g −1 , 44.0%), manifesting the increased capacity and enhanced cycling stability. Figure 4 b displays the galvanostatic charging/discharging curves of the SnS 2−x -450 at 100 mA g −1 . The initial discharging capacity is 1375 mA h g −1 , and the initial charging capacity is 1176 mA h g −1 . Figure 4 c summarizes the rate performances of all samples. At rates of 100, 200, 500, 1000, 2000, and 200 mA g −1 ( Figure 4 d), the discharging capacities of the SnS 2−x -450 microflowers were 1130, 1010, 954, 899, 827, and 1005 mA h g −1 , respectively. Notably, even at a high current density of 2000 mAh g −1 , the SnS 2−x -450 microflowers still retain a high capacity of 827 mAh g −1 . Besides, the capacity at each current density was far higher than that of the SnS 2 , SnS 2−x -400, and SnS 2−x -500. The cycling stability at 1000 mA g −1 was further measured. ( Figure 4 c). After 100 cycles, the SnS 2−x -450 still maintained a high capacity of 712 mA h g −1 , surpassing those of SnS 2 (111 mA h g −1 , 19.0%), SnS 2−x -400 (431 mA h g −1 , 57%), and SnS 2−x -500 (91 mA h g −1 , 13.0%). The capacity of SnS 2−x -450 is still more than twice that of graphite. To further investigate the charge storage mechanism in SnS 2−x microflowers, the kinetics of the charging process was studied to gain more quantitative charge storage processes [ 36 ]. Figure 4 e shows the contributions from the diffusion-controlled process. When the scan rates were increased from 0.1 to 1.0 mV s −1 , the proportions of the capacitive contribution increased. The capacitive contribution reaches 62.6% at 1.0 mV s −1 . Figure 4 f shows the capacitive and diffusion-controlled contributions to charge storage in the SnS 2−x -450-based lithium-ion battery at 1 mV s −1 . The diffusion-controlled regions are mainly located around the peaks of the CV, revealing that the redox peaks are governed by the diffusion, while the rest of the regions are capacitive-controlled. In order to further investigate the electrochemical kinetics, electrochemical impedance spectra (EIS) in Figure S7 shows that SnS 2−x -450 holds enhanced kinetics for Li-ion insertion/extraction. The TEM images and the EDS mapping of the sample after 100 cycles are carried out to reveal the stability of the SnS 2−x nanostructure in Figure S8 . It is found that the microflowers tend to aggregate together, while the nanosheet morphology keeps stable. The EDS mapping in Figure S8 shows the homogeneous distribution of the Sn and S elements in the area, which confirms the excellent stability of SnS 2−x nanostructure. In addition, we studied the electrochemical performance of SnS 2−x microflower electrodes for sodium ion storage. The Na-storage behavior of the SnS 2−x microflower electrode was measured based on the half cell with Na metal anode and SnS 2−x microflower cathodes in the range of 0.01–3 V. CV curves of SnS 2−x microflower-based SIB were first tested at 0.1 mV s −1 . As shown in Figure 5 a, the cathodic peak located at 1.74 V is attributed to the sodium intercalation into SnS 2 host, while the peak at 0.73 V to the conversion reaction, alloying reaction, and solid electrolyte interface (SEI) film formation [ 35 ]. Figure S9 shows the galvanostatic charging/discharging profiles of the SnS 2−x microflower electrode at a current density of 200 mA g −1 at different cycles. The initial discharge capacity is 984 mAh g −1 , and the first charge capacity is 793 mAh g −1 . The observed potential plateaus in the charging/discharging curves correspond to the redox peaks in the CV curves. Figure 5 b shows the cycling performance of SnS 2−x microflower-based SIB at 200 mAh g −1 . The initial capacity of SnS 2−x -450 and SnS 2 is 984, 641 mAh g −1 , respectively. After 30 cycles, the SnS 2−x -450 still retained a capacity of 608 mAhg −1 , which was much higher than SnS 2 (340 mAh g −1 ), demonstrating the improved capacity and cycling stability. Furthermore, the rate performances were investigated in Figure 5 d. Notably, even at a high current density of 5000 mA g −1 , the SnS 2−x -450 still keeps a high capacity of 491 mAh g −1 , showing an excellent rate capability. Besides, the capacity of SnS 2−x -450 was much higher than that of the SnS 2 , SnS 2−x -400, and SnS 2−x -500 at each current density. As displayed in Figure 5 c, at current density of 1000 mA g −1 , SnS 2−x -450 could maintain a capacity of 522 mA h g −1 after 200 cycles, with a capacity retention of 89.5% from 3 to 200 cycles, surpassing those of SnS 2 (84 mAh g −1 , 14.8%), SnS 2−x -400 (96 mAh g −1 , 21.6%), and SnS 2−x -500 (43 mAh g −1 , 7.0%). 3. Conclusions In summary, we have successfully fabricated porous SnS 2−x microflower structure through a facile solvothermal method, followed by the thermal treatment. The porous structure and sulfur vacancies are formed mainly due to the partial loss of sulfur during the annealing under sulfur-deficient environment. The rich sulfur vacancy increases the electric conductivity and the formation of porous structure leads to the facile strain relaxation during battery cycling. In this way, the porous SnS 2−x microflowers exhibit promising performance as the anode for LIBs in terms of high capacity (1375 mAh g −1 at 100 mA g −1 ) and outstanding rate capability (827 mA h g −1 at 2 A g −1 ). For SIBs, a high capacity of ~522 mAh g −1 is achieved at 5 A g −1 after 200 cycles for SnS 2−x microflowers. The simultaneous rational structural design and chemical composition control of SnS 2−x microflowers in this work brings new insight to the synthesis of advanced functional electrode materials and offers great potential for next-generation energy storage devices. Supplementary Materials The following are available online at https://www.mdpi.com/1996-1944/13/2/443/s1 , Figure S1: SEM images of SnS 2 (a, b), SnS 2−x -400 (c, d), SnS 2−x -450 (e, f) and SnS 2−x -500 (g, h). Figure S2: SEM image of a representive SnS 2−x nanoflower and its elemental mapping images of S (b), and Sn (c). Figure S3. TEM images of SnS 2 (a, b), SnS 2−x -400 (c, d), and SnS 2−x -500 (e, f). Figure S4. Nitrogen adsorption-desorption isotherms and pore size distributions (insets) of SnS 2 (a), SnS 2−x -400 (b), SnS 2−x -450 (c) and SnS 2−x -500 (d). Figure S5. CV curves of the LIB based on SnS 2−x -450 nanoflowers. Figure S6. CV curves of SnS 2−x -450 at different scan rates ranging from 0.1 to 1 mV s −1 . Figure S7. EIS of of LIBs based on SnS 2 , SnS 2−x -400, SnS 2−x -450 and SnS 2−x -500 nanoflowers. Figure S8. Charge and discharge curves of SnS 2−x -450 at different cycles as SIBs. Author Contributions Data curation, L.Z., B.Y. and C.S.; Formal analysis, B.Y. and S.S.; Funding acquisition, K.Z.; Investigation, C.S. and K.Z.; Methodology, L.Z.; Project administration, K.Z.; Software, L.Z., S.S. and W.X.; Writing—original draft, L.Z. and K.Z.; Writing—review & editing, C.S., W.X. and K.Z. All authors have read and agreed to the published version of the manuscript. 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SnO 2 Quantum [email protected] Oxide as a High-Rate and Long-Life Anode Material for Lithium-Ion Batteries. Small 2016 , 12 , 588–594. [ Google Scholar ] [ CrossRef ] Zhao, K.; Liu, F.; Niu, C.; Xu, W.; Dong, Y.; Zhang, L.; Xie, S.; Yan, M.; Wei, Q.; Zhao, D.; et al. Graphene Oxide Wrapped Amorphous Copper Vanadium Oxide with Enhanced Capacitive Behavior for High-Rate and Long-Life Lithium-Ion Battery Anodes. Adv. Sci. 2015 , 2 , 1500154. [ Google Scholar ] [ CrossRef ] Figure 1. Schematic of the synthesis of SnS 2 microflowers. Figure 2. ( a ) XRD patterns of SnS 2 , SnS 2−x -400, SnS 2−x -450, and SnS 2−x -500. ( b , c ) SEM images of SnS 2 microflowers and SnS 2−x -450 microflowers. ( d ) TEM image and ( e , f ) canning transmission electron microscopy (STEM) images of SnS 2−x -450 microflowers, showing the atomic resolution of the 2H-SnS 2 . Figure 2. ( a ) XRD patterns of SnS 2 , SnS 2−x -400, SnS 2−x -450, and SnS 2−x -500. ( b , c ) SEM images of SnS 2 microflowers and SnS 2−x -450 microflowers. ( d ) TEM image and ( e , f ) canning transmission electron microscopy (STEM) images of SnS 2−x -450 microflowers, showing the atomic resolution of the 2H-SnS 2 . Figure 3. ( a , b ) Thermogravimetric (TG) curves and their corresponding DSC curves of the SnS 2 and SnS 2−x microflowers. ( c , d ) Sn 3d spectrum and S 2p spectrum for SnS 2−x microflowers. ( e , f ) Sn 3d spectrum and S 2p spectrum for SnS 2 microflowers. Figure 3. ( a , b ) Thermogravimetric (TG) curves and their corresponding DSC curves of the SnS 2 and SnS 2−x microflowers. ( c , d ) Sn 3d spectrum and S 2p spectrum for SnS 2−x microflowers. ( e , f ) Sn 3d spectrum and S 2p spectrum for SnS 2 microflowers. Figure 4. ( a ) Cycling performances at 100 mA g −1 . ( b ) Charge and discharge curves of SnS 2−x -450. ( c ) Rate performances and ( d ) Cycling performances at 1000 mA g −1 . ( e ) Capacitive and diffusion-controlled contributions to charge storage in SnS 2−x -450 at different scan rates of 0.1, 0.5, 0.8, and 1 mV s −1 . ( f ) Capacitive contributions of SnS 2−x -450 to charge storage at 1 mV s −1 . The shaded region is the pseudocapacitive contribution in SnS 2−x -450. Figure 4. ( a ) Cycling performances at 100 mA g −1 . ( b ) Charge and discharge curves of SnS 2−x -450. ( c ) Rate performances and ( d ) Cycling performances at 1000 mA g −1 . ( e ) Capacitive and diffusion-controlled contributions to charge storage in SnS 2−x -450 at different scan rates of 0.1, 0.5, 0.8, and 1 mV s −1 . ( f ) Capacitive contributions of SnS 2−x -450 to charge storage at 1 mV s −1 . The shaded region is the pseudocapacitive contribution in SnS 2−x -450. Figure 5. ( a ) Cyclic voltammetry (CV) curves of of SnS 2−x microflowers. ( b ) Cycling performances of SnS 2 and SnS 2−x microflowers at 200 mA g −1 . ( c ) Cycling performances of SnS 2 , SnS 2−x -400, SnS 2−x -450, and SnS 2−x -500 at 2000 mA g −1 ( d ) Rate performances of SnS 2 , SnS 2−x -450 and SnS 2−x -500 at current densities ranging from 200 to 5000 mA g −1 . ( e ) EIS spectra of the SnS 2 , SnS 2−x -400, SnS 2−x -450, and SnS 2−x -500. Figure 5. ( a ) Cyclic voltammetry (CV) curves of of SnS 2−x microflowers. ( b ) Cycling performances of SnS 2 and SnS 2−x microflowers at 200 mA g −1 . ( c ) Cycling performances of SnS 2 , SnS 2−x -400, SnS 2−x -450, and SnS 2−x -500 at 2000 mA g −1 ( d ) Rate performances of SnS 2 , SnS 2−x -450 and SnS 2−x -500 at current densities ranging from 200 to 5000 mA g −1 . ( e ) EIS spectra of the SnS 2 , SnS 2−x -400, SnS 2−x -450, and SnS 2−x -500. MDPI and ACS Style Zhang, L.; Yao, B.; Sun, C.; Shi, S.; Xu, W.; Zhao, K. Sulfur-Deficient Porous SnS 2−xMicroflowers as Superior Anode for Alkaline Ion Batteries. Materials 2020, 13, 443. https://doi.org/10.3390/ma13020443 AMA Style Zhang L, Yao B, Sun C, Shi S, Xu W, Zhao K. Sulfur-Deficient Porous SnS 2−xMicroflowers as Superior Anode for Alkaline Ion Batteries. Materials. 2020; 13(2):443. https://doi.org/10.3390/ma13020443 Chicago/Turabian Style Zhang, Lei, Bin Yao, Congli Sun, Shanshan Shi, Wangwang Xu, and Kangning Zhao. 2020. "Sulfur-Deficient Porous SnS 2−xMicroflowers as Superior Anode for Alkaline Ion Batteries" Materials13, no. 2: 443. https://doi.org/10.3390/ma13020443
https://www.mdpi.com/1996-1944/13/2/443/xml
HB4390 98TH GENERAL ASSEMBLY 98TH GENERAL ASSEMBLY State of Illinois 2013 and 2014 HB4390 Introduced , by Rep. Patrick J. Verschoore SYNOPSIS AS INTRODUCED: 35 ILCS 105/3-5 35 ILCS 110/3-5 35 ILCS 115/3-5 35 ILCS 120/2-5 Amends the Use Tax Act, the Service Use Tax Act, the Service Occupation Tax Act, and the Retailers' Occupation Tax Act. Provides that medical appliances purchased for use by a person aged 65 or older are exempt from taxation under the Acts. Provides that the Acts' automatic sunset provisions do not apply to that exemption. LRB098 15788 HLH 50821 b FISCAL NOTE ACT MAY APPLY A BILL FOR HB4390 LRB098 15788 HLH 50821 b 1 AN ACT concerning revenue. 2 Be it enacted by the People of the State of Illinois, 3 represented in the General Assembly: 4 Section 5. The Use Tax Act is amended by changing Section 5 3-5 as follows: 6 (35 ILCS 105/3-5) 7 Sec. 3-5. Exemptions. Use of the following tangible 8 personal property is exempt from the tax imposed by this Act: 9 (1) Personal property purchased from a corporation, 10 society, association, foundation, institution, or 11 organization, other than a limited liability company, that is 12 organized and operated as a not-for-profit service enterprise 13 for the benefit of persons 65 years of age or older if the 14 personal property was not purchased by the enterprise for the 15 purpose of resale by the enterprise. 16 (2) Personal property purchased by a not-for-profit 17 Illinois county fair association for use in conducting, 18 operating, or promoting the county fair. 19 (3) Personal property purchased by a not-for-profit arts or 20 cultural organization that establishes, by proof required by 21 the Department by rule, that it has received an exemption under 22 Section 501(c)(3) of the Internal Revenue Code and that is 23 organized and operated primarily for the presentation or HB4390 - 2 - LRB098 15788 HLH 50821 b 1 support of arts or cultural programming, activities, or 2 services. These organizations include, but are not limited to, 3 music and dramatic arts organizations such as symphony 4 orchestras and theatrical groups, arts and cultural service 5 organizations, local arts councils, visual arts organizations, 6 and media arts organizations. On and after the effective date 7 of this amendatory Act of the 92nd General Assembly, however, 8 an entity otherwise eligible for this exemption shall not make 9 tax-free purchases unless it has an active identification 10 number issued by the Department. 11 (4) Personal property purchased by a governmental body, by 12 a corporation, society, association, foundation, or 13 institution organized and operated exclusively for charitable, 14 religious, or educational purposes, or by a not-for-profit 15 corporation, society, association, foundation, institution, or 16 organization that has no compensated officers or employees and 17 that is organized and operated primarily for the recreation of 18 persons 55 years of age or older. A limited liability company 19 may qualify for the exemption under this paragraph only if the 20 limited liability company is organized and operated 21 exclusively for educational purposes. On and after July 1, 22 1987, however, no entity otherwise eligible for this exemption 23 shall make tax-free purchases unless it has an active exemption 24 identification number issued by the Department. 25 (5) Until July 1, 2003, a passenger car that is a 26 replacement vehicle to the extent that the purchase price of HB4390 - 3 - LRB098 15788 HLH 50821 b 1 the car is subject to the Replacement Vehicle Tax. 2 (6) Until July 1, 2003 and beginning again on September 1, 3 2004 through August 30, 2014, graphic arts machinery and 4 equipment, including repair and replacement parts, both new and 5 used, and including that manufactured on special order, 6 certified by the purchaser to be used primarily for graphic 7 arts production, and including machinery and equipment 8 purchased for lease. Equipment includes chemicals or chemicals 9 acting as catalysts but only if the chemicals or chemicals 10 acting as catalysts effect a direct and immediate change upon a 11 graphic arts product. 12 (7) Farm chemicals. 13 (8) Legal tender, currency, medallions, or gold or silver 14 coinage issued by the State of Illinois, the government of the 15 United States of America, or the government of any foreign 16 country, and bullion. 17 (9) Personal property purchased from a teacher-sponsored 18 student organization affiliated with an elementary or 19 secondary school located in Illinois. 20 (10) A motor vehicle that is used for automobile renting, 21 as defined in the Automobile Renting Occupation and Use Tax 22 Act. 23 (11) Farm machinery and equipment, both new and used, 24 including that manufactured on special order, certified by the 25 purchaser to be used primarily for production agriculture or 26 State or federal agricultural programs, including individual HB4390 - 4 - LRB098 15788 HLH 50821 b 1 replacement parts for the machinery and equipment, including 2 machinery and equipment purchased for lease, and including 3 implements of husbandry defined in Section 1-130 of the 4 Illinois Vehicle Code, farm machinery and agricultural 5 chemical and fertilizer spreaders, and nurse wagons required to 6 be registered under Section 3-809 of the Illinois Vehicle Code, 7 but excluding other motor vehicles required to be registered 8 under the Illinois Vehicle Code. Horticultural polyhouses or 9 hoop houses used for propagating, growing, or overwintering 10 plants shall be considered farm machinery and equipment under 11 this item (11). Agricultural chemical tender tanks and dry 12 boxes shall include units sold separately from a motor vehicle 13 required to be licensed and units sold mounted on a motor 14 vehicle required to be licensed if the selling price of the 15 tender is separately stated. 16 Farm machinery and equipment shall include precision 17 farming equipment that is installed or purchased to be 18 installed on farm machinery and equipment including, but not 19 limited to, tractors, harvesters, sprayers, planters, seeders, 20 or spreaders. Precision farming equipment includes, but is not 21 limited to, soil testing sensors, computers, monitors, 22 software, global positioning and mapping systems, and other 23 such equipment. 24 Farm machinery and equipment also includes computers, 25 sensors, software, and related equipment used primarily in the 26 computer-assisted operation of production agriculture HB4390 - 5 - LRB098 15788 HLH 50821 b 1 facilities, equipment, and activities such as, but not limited 2 to, the collection, monitoring, and correlation of animal and 3 crop data for the purpose of formulating animal diets and 4 agricultural chemicals. This item (11) is exempt from the 5 provisions of Section 3-90. 6 (12) Until June 30, 2013, fuel and petroleum products sold 7 to or used by an air common carrier, certified by the carrier 8 to be used for consumption, shipment, or storage in the conduct 9 of its business as an air common carrier, for a flight destined 10 for or returning from a location or locations outside the 11 United States without regard to previous or subsequent domestic 12 stopovers. 13 Beginning July 1, 2013, fuel and petroleum products sold to 14 or used by an air carrier, certified by the carrier to be used 15 for consumption, shipment, or storage in the conduct of its 16 business as an air common carrier, for a flight that (i) is 17 engaged in foreign trade or is engaged in trade between the 18 United States and any of its possessions and (ii) transports at 19 least one individual or package for hire from the city of 20 origination to the city of final destination on the same 21 aircraft, without regard to a change in the flight number of 22 that aircraft. 23 (13) Proceeds of mandatory service charges separately 24 stated on customers' bills for the purchase and consumption of 25 food and beverages purchased at retail from a retailer, to the 26 extent that the proceeds of the service charge are in fact HB4390 - 6 - LRB098 15788 HLH 50821 b 1 turned over as tips or as a substitute for tips to the 2 employees who participate directly in preparing, serving, 3 hosting or cleaning up the food or beverage function with 4 respect to which the service charge is imposed. 5 (14) Until July 1, 2003, oil field exploration, drilling, 6 and production equipment, including (i) rigs and parts of rigs, 7 rotary rigs, cable tool rigs, and workover rigs, (ii) pipe and 8 tubular goods, including casing and drill strings, (iii) pumps 9 and pump-jack units, (iv) storage tanks and flow lines, (v) any 10 individual replacement part for oil field exploration, 11 drilling, and production equipment, and (vi) machinery and 12 equipment purchased for lease; but excluding motor vehicles 13 required to be registered under the Illinois Vehicle Code. 14 (15) Photoprocessing machinery and equipment, including 15 repair and replacement parts, both new and used, including that 16 manufactured on special order, certified by the purchaser to be 17 used primarily for photoprocessing, and including 18 photoprocessing machinery and equipment purchased for lease. 19 (16) Coal and aggregate exploration, mining, off-highway 20 offhighway hauling, processing, maintenance, and reclamation 21 equipment, including replacement parts and equipment, and 22 including equipment purchased for lease, but excluding motor 23 vehicles required to be registered under the Illinois Vehicle 24 Code. The changes made to this Section by Public Act 97-767 25 apply on and after July 1, 2003, but no claim for credit or 26 refund is allowed on or after August 16, 2013 ( the effective HB4390 - 7 - LRB098 15788 HLH 50821 b 1 date of Public Act 98-456) this amendatory Act of the 98th 2 General Assembly for such taxes paid during the period 3 beginning July 1, 2003 and ending on August 16, 2013 ( the 4 effective date of Public Act 98-456) this amendatory Act of the 5 98th General Assembly . 6 (17) Until July 1, 2003, distillation machinery and 7 equipment, sold as a unit or kit, assembled or installed by the 8 retailer, certified by the user to be used only for the 9 production of ethyl alcohol that will be used for consumption 10 as motor fuel or as a component of motor fuel for the personal 11 use of the user, and not subject to sale or resale. 12 (18) Manufacturing and assembling machinery and equipment 13 used primarily in the process of manufacturing or assembling 14 tangible personal property for wholesale or retail sale or 15 lease, whether that sale or lease is made directly by the 16 manufacturer or by some other person, whether the materials 17 used in the process are owned by the manufacturer or some other 18 person, or whether that sale or lease is made apart from or as 19 an incident to the seller's engaging in the service occupation 20 of producing machines, tools, dies, jigs, patterns, gauges, or 21 other similar items of no commercial value on special order for 22 a particular purchaser. The exemption provided by this 23 paragraph (18) does not include machinery and equipment used in 24 (i) the generation of electricity for wholesale or retail sale; 25 (ii) the generation or treatment of natural or artificial gas 26 for wholesale or retail sale that is delivered to customers HB4390 - 8 - LRB098 15788 HLH 50821 b 1 through pipes, pipelines, or mains; or (iii) the treatment of 2 water for wholesale or retail sale that is delivered to 3 customers through pipes, pipelines, or mains. The provisions of 4 Public Act 98-583 this amendatory Act of the 98th General 5 Assembly are declaratory of existing law as to the meaning and 6 scope of this exemption. 7 (19) Personal property delivered to a purchaser or 8 purchaser's donee inside Illinois when the purchase order for 9 that personal property was received by a florist located 10 outside Illinois who has a florist located inside Illinois 11 deliver the personal property. 12 (20) Semen used for artificial insemination of livestock 13 for direct agricultural production. 14 (21) Horses, or interests in horses, registered with and 15 meeting the requirements of any of the Arabian Horse Club 16 Registry of America, Appaloosa Horse Club, American Quarter 17 Horse Association, United States Trotting Association, or 18 Jockey Club, as appropriate, used for purposes of breeding or 19 racing for prizes. This item (21) is exempt from the provisions 20 of Section 3-90, and the exemption provided for under this item 21 (21) applies for all periods beginning May 30, 1995, but no 22 claim for credit or refund is allowed on or after January 1, 23 2008 for such taxes paid during the period beginning May 30, 24 2000 and ending on January 1, 2008. 25 (22) Computers and communications equipment utilized for 26 any hospital purpose and equipment used in the diagnosis, HB4390 - 9 - LRB098 15788 HLH 50821 b 1 analysis, or treatment of hospital patients purchased by a 2 lessor who leases the equipment, under a lease of one year or 3 longer executed or in effect at the time the lessor would 4 otherwise be subject to the tax imposed by this Act, to a 5 hospital that has been issued an active tax exemption 6 identification number by the Department under Section 1g of the 7 Retailers' Occupation Tax Act. If the equipment is leased in a 8 manner that does not qualify for this exemption or is used in 9 any other non-exempt manner, the lessor shall be liable for the 10 tax imposed under this Act or the Service Use Tax Act, as the 11 case may be, based on the fair market value of the property at 12 the time the non-qualifying use occurs. No lessor shall collect 13 or attempt to collect an amount (however designated) that 14 purports to reimburse that lessor for the tax imposed by this 15 Act or the Service Use Tax Act, as the case may be, if the tax 16 has not been paid by the lessor. If a lessor improperly 17 collects any such amount from the lessee, the lessee shall have 18 a legal right to claim a refund of that amount from the lessor. 19 If, however, that amount is not refunded to the lessee for any 20 reason, the lessor is liable to pay that amount to the 21 Department. 22 (23) Personal property purchased by a lessor who leases the 23 property, under a lease of one year or longer executed or in 24 effect at the time the lessor would otherwise be subject to the 25 tax imposed by this Act, to a governmental body that has been 26 issued an active sales tax exemption identification number by HB4390 - 10 - LRB098 15788 HLH 50821 b 1 the Department under Section 1g of the Retailers' Occupation 2 Tax Act. If the property is leased in a manner that does not 3 qualify for this exemption or used in any other non-exempt 4 manner, the lessor shall be liable for the tax imposed under 5 this Act or the Service Use Tax Act, as the case may be, based 6 on the fair market value of the property at the time the 7 non-qualifying use occurs. No lessor shall collect or attempt 8 to collect an amount (however designated) that purports to 9 reimburse that lessor for the tax imposed by this Act or the 10 Service Use Tax Act, as the case may be, if the tax has not been 11 paid by the lessor. If a lessor improperly collects any such 12 amount from the lessee, the lessee shall have a legal right to 13 claim a refund of that amount from the lessor. If, however, 14 that amount is not refunded to the lessee for any reason, the 15 lessor is liable to pay that amount to the Department. 16 (24) Beginning with taxable years ending on or after 17 December 31, 1995 and ending with taxable years ending on or 18 before December 31, 2004, personal property that is donated for 19 disaster relief to be used in a State or federally declared 20 disaster area in Illinois or bordering Illinois by a 21 manufacturer or retailer that is registered in this State to a 22 corporation, society, association, foundation, or institution 23 that has been issued a sales tax exemption identification 24 number by the Department that assists victims of the disaster 25 who reside within the declared disaster area. 26 (25) Beginning with taxable years ending on or after HB4390 - 11 - LRB098 15788 HLH 50821 b 1 December 31, 1995 and ending with taxable years ending on or 2 before December 31, 2004, personal property that is used in the 3 performance of infrastructure repairs in this State, including 4 but not limited to municipal roads and streets, access roads, 5 bridges, sidewalks, waste disposal systems, water and sewer 6 line extensions, water distribution and purification 7 facilities, storm water drainage and retention facilities, and 8 sewage treatment facilities, resulting from a State or 9 federally declared disaster in Illinois or bordering Illinois 10 when such repairs are initiated on facilities located in the 11 declared disaster area within 6 months after the disaster. 12 (26) Beginning July 1, 1999, game or game birds purchased 13 at a "game breeding and hunting preserve area" as that term is 14 used in the Wildlife Code. This paragraph is exempt from the 15 provisions of Section 3-90. 16 (27) A motor vehicle, as that term is defined in Section 17 1-146 of the Illinois Vehicle Code, that is donated to a 18 corporation, limited liability company, society, association, 19 foundation, or institution that is determined by the Department 20 to be organized and operated exclusively for educational 21 purposes. For purposes of this exemption, "a corporation, 22 limited liability company, society, association, foundation, 23 or institution organized and operated exclusively for 24 educational purposes" means all tax-supported public schools, 25 private schools that offer systematic instruction in useful 26 branches of learning by methods common to public schools and HB4390 - 12 - LRB098 15788 HLH 50821 b 1 that compare favorably in their scope and intensity with the 2 course of study presented in tax-supported schools, and 3 vocational or technical schools or institutes organized and 4 operated exclusively to provide a course of study of not less 5 than 6 weeks duration and designed to prepare individuals to 6 follow a trade or to pursue a manual, technical, mechanical, 7 industrial, business, or commercial occupation. 8 (28) Beginning January 1, 2000, personal property, 9 including food, purchased through fundraising events for the 10 benefit of a public or private elementary or secondary school, 11 a group of those schools, or one or more school districts if 12 the events are sponsored by an entity recognized by the school 13 district that consists primarily of volunteers and includes 14 parents and teachers of the school children. This paragraph 15 does not apply to fundraising events (i) for the benefit of 16 private home instruction or (ii) for which the fundraising 17 entity purchases the personal property sold at the events from 18 another individual or entity that sold the property for the 19 purpose of resale by the fundraising entity and that profits 20 from the sale to the fundraising entity. This paragraph is 21 exempt from the provisions of Section 3-90. 22 (29) Beginning January 1, 2000 and through December 31, 23 2001, new or used automatic vending machines that prepare and 24 serve hot food and beverages, including coffee, soup, and other 25 items, and replacement parts for these machines. Beginning 26 January 1, 2002 and through June 30, 2003, machines and parts HB4390 - 13 - LRB098 15788 HLH 50821 b 1 for machines used in commercial, coin-operated amusement and 2 vending business if a use or occupation tax is paid on the 3 gross receipts derived from the use of the commercial, 4 coin-operated amusement and vending machines. This paragraph 5 is exempt from the provisions of Section 3-90. 6 (30) Beginning January 1, 2001 and through June 30, 2016, 7 food for human consumption that is to be consumed off the 8 premises where it is sold (other than alcoholic beverages, soft 9 drinks, and food that has been prepared for immediate 10 consumption) and prescription and nonprescription medicines, 11 drugs, medical appliances, and insulin, urine testing 12 materials, syringes, and needles used by diabetics, for human 13 use, when purchased for use by a person receiving medical 14 assistance under Article V of the Illinois Public Aid Code who 15 resides in a licensed long-term care facility, as defined in 16 the Nursing Home Care Act, or in a licensed facility as defined 17 in the ID/DD Community Care Act or the Specialized Mental 18 Health Rehabilitation Act of 2013. 19 (31) Beginning on the effective date of this amendatory Act 20 of the 92nd General Assembly, computers and communications 21 equipment utilized for any hospital purpose and equipment used 22 in the diagnosis, analysis, or treatment of hospital patients 23 purchased by a lessor who leases the equipment, under a lease 24 of one year or longer executed or in effect at the time the 25 lessor would otherwise be subject to the tax imposed by this 26 Act, to a hospital that has been issued an active tax exemption HB4390 - 14 - LRB098 15788 HLH 50821 b 1 identification number by the Department under Section 1g of the 2 Retailers' Occupation Tax Act. If the equipment is leased in a 3 manner that does not qualify for this exemption or is used in 4 any other nonexempt manner, the lessor shall be liable for the 5 tax imposed under this Act or the Service Use Tax Act, as the 6 case may be, based on the fair market value of the property at 7 the time the nonqualifying use occurs. No lessor shall collect 8 or attempt to collect an amount (however designated) that 9 purports to reimburse that lessor for the tax imposed by this 10 Act or the Service Use Tax Act, as the case may be, if the tax 11 has not been paid by the lessor. If a lessor improperly 12 collects any such amount from the lessee, the lessee shall have 13 a legal right to claim a refund of that amount from the lessor. 14 If, however, that amount is not refunded to the lessee for any 15 reason, the lessor is liable to pay that amount to the 16 Department. This paragraph is exempt from the provisions of 17 Section 3-90. 18 (32) Beginning on the effective date of this amendatory Act 19 of the 92nd General Assembly, personal property purchased by a 20 lessor who leases the property, under a lease of one year or 21 longer executed or in effect at the time the lessor would 22 otherwise be subject to the tax imposed by this Act, to a 23 governmental body that has been issued an active sales tax 24 exemption identification number by the Department under 25 Section 1g of the Retailers' Occupation Tax Act. If the 26 property is leased in a manner that does not qualify for this HB4390 - 15 - LRB098 15788 HLH 50821 b 1 exemption or used in any other nonexempt manner, the lessor 2 shall be liable for the tax imposed under this Act or the 3 Service Use Tax Act, as the case may be, based on the fair 4 market value of the property at the time the nonqualifying use 5 occurs. No lessor shall collect or attempt to collect an amount 6 (however designated) that purports to reimburse that lessor for 7 the tax imposed by this Act or the Service Use Tax Act, as the 8 case may be, if the tax has not been paid by the lessor. If a 9 lessor improperly collects any such amount from the lessee, the 10 lessee shall have a legal right to claim a refund of that 11 amount from the lessor. If, however, that amount is not 12 refunded to the lessee for any reason, the lessor is liable to 13 pay that amount to the Department. This paragraph is exempt 14 from the provisions of Section 3-90. 15 (33) On and after July 1, 2003 and through June 30, 2004, 16 the use in this State of motor vehicles of the second division 17 with a gross vehicle weight in excess of 8,000 pounds and that 18 are subject to the commercial distribution fee imposed under 19 Section 3-815.1 of the Illinois Vehicle Code. Beginning on July 20 1, 2004 and through June 30, 2005, the use in this State of 21 motor vehicles of the second division: (i) with a gross vehicle 22 weight rating in excess of 8,000 pounds; (ii) that are subject 23 to the commercial distribution fee imposed under Section 24 3-815.1 of the Illinois Vehicle Code; and (iii) that are 25 primarily used for commercial purposes. Through June 30, 2005, 26 this exemption applies to repair and replacement parts added HB4390 - 16 - LRB098 15788 HLH 50821 b 1 after the initial purchase of such a motor vehicle if that 2 motor vehicle is used in a manner that would qualify for the 3 rolling stock exemption otherwise provided for in this Act. For 4 purposes of this paragraph, the term "used for commercial 5 purposes" means the transportation of persons or property in 6 furtherance of any commercial or industrial enterprise, 7 whether for-hire or not. 8 (34) Beginning January 1, 2008, tangible personal property 9 used in the construction or maintenance of a community water 10 supply, as defined under Section 3.145 of the Environmental 11 Protection Act, that is operated by a not-for-profit 12 corporation that holds a valid water supply permit issued under 13 Title IV of the Environmental Protection Act. This paragraph is 14 exempt from the provisions of Section 3-90. 15 (35) Beginning January 1, 2010, materials, parts, 16 equipment, components, and furnishings incorporated into or 17 upon an aircraft as part of the modification, refurbishment, 18 completion, replacement, repair, or maintenance of the 19 aircraft. This exemption includes consumable supplies used in 20 the modification, refurbishment, completion, replacement, 21 repair, and maintenance of aircraft, but excludes any 22 materials, parts, equipment, components, and consumable 23 supplies used in the modification, replacement, repair, and 24 maintenance of aircraft engines or power plants, whether such 25 engines or power plants are installed or uninstalled upon any 26 such aircraft. "Consumable supplies" include, but are not HB4390 - 17 - LRB098 15788 HLH 50821 b 1 limited to, adhesive, tape, sandpaper, general purpose 2 lubricants, cleaning solution, latex gloves, and protective 3 films. This exemption applies only to the use of qualifying 4 tangible personal property by persons who modify, refurbish, 5 complete, repair, replace, or maintain aircraft and who (i) 6 hold an Air Agency Certificate and are empowered to operate an 7 approved repair station by the Federal Aviation 8 Administration, (ii) have a Class IV Rating, and (iii) conduct 9 operations in accordance with Part 145 of the Federal Aviation 10 Regulations. The exemption does not include aircraft operated 11 by a commercial air carrier providing scheduled passenger air 12 service pursuant to authority issued under Part 121 or Part 129 13 of the Federal Aviation Regulations. The changes made to this 14 paragraph (35) by Public Act 98-534 this amendatory Act of the 15 98th General Assembly are declarative of existing law. 16 (36) Tangible personal property purchased by a 17 public-facilities corporation, as described in Section 18 11-65-10 of the Illinois Municipal Code, for purposes of 19 constructing or furnishing a municipal convention hall, but 20 only if the legal title to the municipal convention hall is 21 transferred to the municipality without any further 22 consideration by or on behalf of the municipality at the time 23 of the completion of the municipal convention hall or upon the 24 retirement or redemption of any bonds or other debt instruments 25 issued by the public-facilities corporation in connection with 26 the development of the municipal convention hall. This HB4390 - 18 - LRB098 15788 HLH 50821 b 1 exemption includes existing public-facilities corporations as 2 provided in Section 11-65-25 of the Illinois Municipal Code. 3 This paragraph is exempt from the provisions of Section 3-90. 4 (37) Medical appliances purchased for use by a person aged 5 65 or older. This paragraph is exempt from the provisions of 6 Section 3-90. 7 (Source: P.A. 97-38, eff. 6-28-11; 97-227, eff. 1-1-12; 97-431, 8 eff. 8-16-11; 97-636, eff. 6-1-12; 97-767, eff. 7-9-12; 98-104, 9 eff. 7-22-13; 98-422, eff. 8-16-13; 98-456, eff. 8-16-13; 10 98-534, eff. 8-23-13; 98-574, eff. 1-1-14; 98-583, eff. 1-1-14; 11 revised 9-9-13.) 12 Section 10. The Service Use Tax Act is amended by changing 13 Section 3-5 as follows: 14 (35 ILCS 110/3-5) 15 Sec. 3-5. Exemptions. Use of the following tangible 16 personal property is exempt from the tax imposed by this Act: 17 (1) Personal property purchased from a corporation, 18 society, association, foundation, institution, or 19 organization, other than a limited liability company, that is 20 organized and operated as a not-for-profit service enterprise 21 for the benefit of persons 65 years of age or older if the 22 personal property was not purchased by the enterprise for the 23 purpose of resale by the enterprise. 24 (2) Personal property purchased by a non-profit Illinois HB4390 - 19 - LRB098 15788 HLH 50821 b 1 county fair association for use in conducting, operating, or 2 promoting the county fair. 3 (3) Personal property purchased by a not-for-profit arts or 4 cultural organization that establishes, by proof required by 5 the Department by rule, that it has received an exemption under 6 Section 501(c)(3) of the Internal Revenue Code and that is 7 organized and operated primarily for the presentation or 8 support of arts or cultural programming, activities, or 9 services. These organizations include, but are not limited to, 10 music and dramatic arts organizations such as symphony 11 orchestras and theatrical groups, arts and cultural service 12 organizations, local arts councils, visual arts organizations, 13 and media arts organizations. On and after the effective date 14 of this amendatory Act of the 92nd General Assembly, however, 15 an entity otherwise eligible for this exemption shall not make 16 tax-free purchases unless it has an active identification 17 number issued by the Department. 18 (4) Legal tender, currency, medallions, or gold or silver 19 coinage issued by the State of Illinois, the government of the 20 United States of America, or the government of any foreign 21 country, and bullion. 22 (5) Until July 1, 2003 and beginning again on September 1, 23 2004 through August 30, 2014, graphic arts machinery and 24 equipment, including repair and replacement parts, both new and 25 used, and including that manufactured on special order or 26 purchased for lease, certified by the purchaser to be used HB4390 - 20 - LRB098 15788 HLH 50821 b 1 primarily for graphic arts production. Equipment includes 2 chemicals or chemicals acting as catalysts but only if the 3 chemicals or chemicals acting as catalysts effect a direct and 4 immediate change upon a graphic arts product. 5 (6) Personal property purchased from a teacher-sponsored 6 student organization affiliated with an elementary or 7 secondary school located in Illinois. 8 (7) Farm machinery and equipment, both new and used, 9 including that manufactured on special order, certified by the 10 purchaser to be used primarily for production agriculture or 11 State or federal agricultural programs, including individual 12 replacement parts for the machinery and equipment, including 13 machinery and equipment purchased for lease, and including 14 implements of husbandry defined in Section 1-130 of the 15 Illinois Vehicle Code, farm machinery and agricultural 16 chemical and fertilizer spreaders, and nurse wagons required to 17 be registered under Section 3-809 of the Illinois Vehicle Code, 18 but excluding other motor vehicles required to be registered 19 under the Illinois Vehicle Code. Horticultural polyhouses or 20 hoop houses used for propagating, growing, or overwintering 21 plants shall be considered farm machinery and equipment under 22 this item (7). Agricultural chemical tender tanks and dry boxes 23 shall include units sold separately from a motor vehicle 24 required to be licensed and units sold mounted on a motor 25 vehicle required to be licensed if the selling price of the 26 tender is separately stated. HB4390 - 21 - LRB098 15788 HLH 50821 b 1 Farm machinery and equipment shall include precision 2 farming equipment that is installed or purchased to be 3 installed on farm machinery and equipment including, but not 4 limited to, tractors, harvesters, sprayers, planters, seeders, 5 or spreaders. Precision farming equipment includes, but is not 6 limited to, soil testing sensors, computers, monitors, 7 software, global positioning and mapping systems, and other 8 such equipment. 9 Farm machinery and equipment also includes computers, 10 sensors, software, and related equipment used primarily in the 11 computer-assisted operation of production agriculture 12 facilities, equipment, and activities such as, but not limited 13 to, the collection, monitoring, and correlation of animal and 14 crop data for the purpose of formulating animal diets and 15 agricultural chemicals. This item (7) is exempt from the 16 provisions of Section 3-75. 17 (8) Until June 30, 2013, fuel and petroleum products sold 18 to or used by an air common carrier, certified by the carrier 19 to be used for consumption, shipment, or storage in the conduct 20 of its business as an air common carrier, for a flight destined 21 for or returning from a location or locations outside the 22 United States without regard to previous or subsequent domestic 23 stopovers. 24 Beginning July 1, 2013, fuel and petroleum products sold to 25 or used by an air carrier, certified by the carrier to be used 26 for consumption, shipment, or storage in the conduct of its HB4390 - 22 - LRB098 15788 HLH 50821 b 1 business as an air common carrier, for a flight that (i) is 2 engaged in foreign trade or is engaged in trade between the 3 United States and any of its possessions and (ii) transports at 4 least one individual or package for hire from the city of 5 origination to the city of final destination on the same 6 aircraft, without regard to a change in the flight number of 7 that aircraft. 8 (9) Proceeds of mandatory service charges separately 9 stated on customers' bills for the purchase and consumption of 10 food and beverages acquired as an incident to the purchase of a 11 service from a serviceman, to the extent that the proceeds of 12 the service charge are in fact turned over as tips or as a 13 substitute for tips to the employees who participate directly 14 in preparing, serving, hosting or cleaning up the food or 15 beverage function with respect to which the service charge is 16 imposed. 17 (10) Until July 1, 2003, oil field exploration, drilling, 18 and production equipment, including (i) rigs and parts of rigs, 19 rotary rigs, cable tool rigs, and workover rigs, (ii) pipe and 20 tubular goods, including casing and drill strings, (iii) pumps 21 and pump-jack units, (iv) storage tanks and flow lines, (v) any 22 individual replacement part for oil field exploration, 23 drilling, and production equipment, and (vi) machinery and 24 equipment purchased for lease; but excluding motor vehicles 25 required to be registered under the Illinois Vehicle Code. 26 (11) Proceeds from the sale of photoprocessing machinery HB4390 - 23 - LRB098 15788 HLH 50821 b 1 and equipment, including repair and replacement parts, both new 2 and used, including that manufactured on special order, 3 certified by the purchaser to be used primarily for 4 photoprocessing, and including photoprocessing machinery and 5 equipment purchased for lease. 6 (12) Coal and aggregate exploration, mining, off-highway 7 offhighway hauling, processing, maintenance, and reclamation 8 equipment, including replacement parts and equipment, and 9 including equipment purchased for lease, but excluding motor 10 vehicles required to be registered under the Illinois Vehicle 11 Code. The changes made to this Section by Public Act 97-767 12 apply on and after July 1, 2003, but no claim for credit or 13 refund is allowed on or after August 16, 2013 ( the effective 14 date of Public Act 98-456) this amendatory Act of the 98th 15 General Assembly for such taxes paid during the period 16 beginning July 1, 2003 and ending on August 16, 2013 ( the 17 effective date of Public Act 98-456) this amendatory Act of the 18 98th General Assembly . 19 (13) Semen used for artificial insemination of livestock 20 for direct agricultural production. 21 (14) Horses, or interests in horses, registered with and 22 meeting the requirements of any of the Arabian Horse Club 23 Registry of America, Appaloosa Horse Club, American Quarter 24 Horse Association, United States Trotting Association, or 25 Jockey Club, as appropriate, used for purposes of breeding or 26 racing for prizes. This item (14) is exempt from the provisions HB4390 - 24 - LRB098 15788 HLH 50821 b 1 of Section 3-75, and the exemption provided for under this item 2 (14) applies for all periods beginning May 30, 1995, but no 3 claim for credit or refund is allowed on or after the effective 4 date of this amendatory Act of the 95th General Assembly for 5 such taxes paid during the period beginning May 30, 2000 and 6 ending on the effective date of this amendatory Act of the 95th 7 General Assembly. 8 (15) Computers and communications equipment utilized for 9 any hospital purpose and equipment used in the diagnosis, 10 analysis, or treatment of hospital patients purchased by a 11 lessor who leases the equipment, under a lease of one year or 12 longer executed or in effect at the time the lessor would 13 otherwise be subject to the tax imposed by this Act, to a 14 hospital that has been issued an active tax exemption 15 identification number by the Department under Section 1g of the 16 Retailers' Occupation Tax Act. If the equipment is leased in a 17 manner that does not qualify for this exemption or is used in 18 any other non-exempt manner, the lessor shall be liable for the 19 tax imposed under this Act or the Use Tax Act, as the case may 20 be, based on the fair market value of the property at the time 21 the non-qualifying use occurs. No lessor shall collect or 22 attempt to collect an amount (however designated) that purports 23 to reimburse that lessor for the tax imposed by this Act or the 24 Use Tax Act, as the case may be, if the tax has not been paid by 25 the lessor. If a lessor improperly collects any such amount 26 from the lessee, the lessee shall have a legal right to claim a HB4390 - 25 - LRB098 15788 HLH 50821 b 1 refund of that amount from the lessor. If, however, that amount 2 is not refunded to the lessee for any reason, the lessor is 3 liable to pay that amount to the Department. 4 (16) Personal property purchased by a lessor who leases the 5 property, under a lease of one year or longer executed or in 6 effect at the time the lessor would otherwise be subject to the 7 tax imposed by this Act, to a governmental body that has been 8 issued an active tax exemption identification number by the 9 Department under Section 1g of the Retailers' Occupation Tax 10 Act. If the property is leased in a manner that does not 11 qualify for this exemption or is used in any other non-exempt 12 manner, the lessor shall be liable for the tax imposed under 13 this Act or the Use Tax Act, as the case may be, based on the 14 fair market value of the property at the time the 15 non-qualifying use occurs. No lessor shall collect or attempt 16 to collect an amount (however designated) that purports to 17 reimburse that lessor for the tax imposed by this Act or the 18 Use Tax Act, as the case may be, if the tax has not been paid by 19 the lessor. If a lessor improperly collects any such amount 20 from the lessee, the lessee shall have a legal right to claim a 21 refund of that amount from the lessor. If, however, that amount 22 is not refunded to the lessee for any reason, the lessor is 23 liable to pay that amount to the Department. 24 (17) Beginning with taxable years ending on or after 25 December 31, 1995 and ending with taxable years ending on or 26 before December 31, 2004, personal property that is donated for HB4390 - 26 - LRB098 15788 HLH 50821 b 1 disaster relief to be used in a State or federally declared 2 disaster area in Illinois or bordering Illinois by a 3 manufacturer or retailer that is registered in this State to a 4 corporation, society, association, foundation, or institution 5 that has been issued a sales tax exemption identification 6 number by the Department that assists victims of the disaster 7 who reside within the declared disaster area. 8 (18) Beginning with taxable years ending on or after 9 December 31, 1995 and ending with taxable years ending on or 10 before December 31, 2004, personal property that is used in the 11 performance of infrastructure repairs in this State, including 12 but not limited to municipal roads and streets, access roads, 13 bridges, sidewalks, waste disposal systems, water and sewer 14 line extensions, water distribution and purification 15 facilities, storm water drainage and retention facilities, and 16 sewage treatment facilities, resulting from a State or 17 federally declared disaster in Illinois or bordering Illinois 18 when such repairs are initiated on facilities located in the 19 declared disaster area within 6 months after the disaster. 20 (19) Beginning July 1, 1999, game or game birds purchased 21 at a "game breeding and hunting preserve area" as that term is 22 used in the Wildlife Code. This paragraph is exempt from the 23 provisions of Section 3-75. 24 (20) A motor vehicle, as that term is defined in Section 25 1-146 of the Illinois Vehicle Code, that is donated to a 26 corporation, limited liability company, society, association, HB4390 - 27 - LRB098 15788 HLH 50821 b 1 foundation, or institution that is determined by the Department 2 to be organized and operated exclusively for educational 3 purposes. For purposes of this exemption, "a corporation, 4 limited liability company, society, association, foundation, 5 or institution organized and operated exclusively for 6 educational purposes" means all tax-supported public schools, 7 private schools that offer systematic instruction in useful 8 branches of learning by methods common to public schools and 9 that compare favorably in their scope and intensity with the 10 course of study presented in tax-supported schools, and 11 vocational or technical schools or institutes organized and 12 operated exclusively to provide a course of study of not less 13 than 6 weeks duration and designed to prepare individuals to 14 follow a trade or to pursue a manual, technical, mechanical, 15 industrial, business, or commercial occupation. 16 (21) Beginning January 1, 2000, personal property, 17 including food, purchased through fundraising events for the 18 benefit of a public or private elementary or secondary school, 19 a group of those schools, or one or more school districts if 20 the events are sponsored by an entity recognized by the school 21 district that consists primarily of volunteers and includes 22 parents and teachers of the school children. This paragraph 23 does not apply to fundraising events (i) for the benefit of 24 private home instruction or (ii) for which the fundraising 25 entity purchases the personal property sold at the events from 26 another individual or entity that sold the property for the HB4390 - 28 - LRB098 15788 HLH 50821 b 1 purpose of resale by the fundraising entity and that profits 2 from the sale to the fundraising entity. This paragraph is 3 exempt from the provisions of Section 3-75. 4 (22) Beginning January 1, 2000 and through December 31, 5 2001, new or used automatic vending machines that prepare and 6 serve hot food and beverages, including coffee, soup, and other 7 items, and replacement parts for these machines. Beginning 8 January 1, 2002 and through June 30, 2003, machines and parts 9 for machines used in commercial, coin-operated amusement and 10 vending business if a use or occupation tax is paid on the 11 gross receipts derived from the use of the commercial, 12 coin-operated amusement and vending machines. This paragraph 13 is exempt from the provisions of Section 3-75. 14 (23) Beginning August 23, 2001 and through June 30, 2016, 15 food for human consumption that is to be consumed off the 16 premises where it is sold (other than alcoholic beverages, soft 17 drinks, and food that has been prepared for immediate 18 consumption) and prescription and nonprescription medicines, 19 drugs, medical appliances, and insulin, urine testing 20 materials, syringes, and needles used by diabetics, for human 21 use, when purchased for use by a person receiving medical 22 assistance under Article V of the Illinois Public Aid Code who 23 resides in a licensed long-term care facility, as defined in 24 the Nursing Home Care Act, or in a licensed facility as defined 25 in the ID/DD Community Care Act or the Specialized Mental 26 Health Rehabilitation Act of 2013. HB4390 - 29 - LRB098 15788 HLH 50821 b 1 (24) Beginning on the effective date of this amendatory Act 2 of the 92nd General Assembly, computers and communications 3 equipment utilized for any hospital purpose and equipment used 4 in the diagnosis, analysis, or treatment of hospital patients 5 purchased by a lessor who leases the equipment, under a lease 6 of one year or longer executed or in effect at the time the 7 lessor would otherwise be subject to the tax imposed by this 8 Act, to a hospital that has been issued an active tax exemption 9 identification number by the Department under Section 1g of the 10 Retailers' Occupation Tax Act. If the equipment is leased in a 11 manner that does not qualify for this exemption or is used in 12 any other nonexempt manner, the lessor shall be liable for the 13 tax imposed under this Act or the Use Tax Act, as the case may 14 be, based on the fair market value of the property at the time 15 the nonqualifying use occurs. No lessor shall collect or 16 attempt to collect an amount (however designated) that purports 17 to reimburse that lessor for the tax imposed by this Act or the 18 Use Tax Act, as the case may be, if the tax has not been paid by 19 the lessor. If a lessor improperly collects any such amount 20 from the lessee, the lessee shall have a legal right to claim a 21 refund of that amount from the lessor. If, however, that amount 22 is not refunded to the lessee for any reason, the lessor is 23 liable to pay that amount to the Department. This paragraph is 24 exempt from the provisions of Section 3-75. 25 (25) Beginning on the effective date of this amendatory Act 26 of the 92nd General Assembly, personal property purchased by a HB4390 - 30 - LRB098 15788 HLH 50821 b 1 lessor who leases the property, under a lease of one year or 2 longer executed or in effect at the time the lessor would 3 otherwise be subject to the tax imposed by this Act, to a 4 governmental body that has been issued an active tax exemption 5 identification number by the Department under Section 1g of the 6 Retailers' Occupation Tax Act. If the property is leased in a 7 manner that does not qualify for this exemption or is used in 8 any other nonexempt manner, the lessor shall be liable for the 9 tax imposed under this Act or the Use Tax Act, as the case may 10 be, based on the fair market value of the property at the time 11 the nonqualifying use occurs. No lessor shall collect or 12 attempt to collect an amount (however designated) that purports 13 to reimburse that lessor for the tax imposed by this Act or the 14 Use Tax Act, as the case may be, if the tax has not been paid by 15 the lessor. If a lessor improperly collects any such amount 16 from the lessee, the lessee shall have a legal right to claim a 17 refund of that amount from the lessor. If, however, that amount 18 is not refunded to the lessee for any reason, the lessor is 19 liable to pay that amount to the Department. This paragraph is 20 exempt from the provisions of Section 3-75. 21 (26) Beginning January 1, 2008, tangible personal property 22 used in the construction or maintenance of a community water 23 supply, as defined under Section 3.145 of the Environmental 24 Protection Act, that is operated by a not-for-profit 25 corporation that holds a valid water supply permit issued under 26 Title IV of the Environmental Protection Act. This paragraph is HB4390 - 31 - LRB098 15788 HLH 50821 b 1 exempt from the provisions of Section 3-75. 2 (27) Beginning January 1, 2010, materials, parts, 3 equipment, components, and furnishings incorporated into or 4 upon an aircraft as part of the modification, refurbishment, 5 completion, replacement, repair, or maintenance of the 6 aircraft. This exemption includes consumable supplies used in 7 the modification, refurbishment, completion, replacement, 8 repair, and maintenance of aircraft, but excludes any 9 materials, parts, equipment, components, and consumable 10 supplies used in the modification, replacement, repair, and 11 maintenance of aircraft engines or power plants, whether such 12 engines or power plants are installed or uninstalled upon any 13 such aircraft. "Consumable supplies" include, but are not 14 limited to, adhesive, tape, sandpaper, general purpose 15 lubricants, cleaning solution, latex gloves, and protective 16 films. This exemption applies only to the use of qualifying 17 tangible personal property transferred incident to the 18 modification, refurbishment, completion, replacement, repair, 19 or maintenance of aircraft by persons who (i) hold an Air 20 Agency Certificate and are empowered to operate an approved 21 repair station by the Federal Aviation Administration, (ii) 22 have a Class IV Rating, and (iii) conduct operations in 23 accordance with Part 145 of the Federal Aviation Regulations. 24 The exemption does not include aircraft operated by a 25 commercial air carrier providing scheduled passenger air 26 service pursuant to authority issued under Part 121 or Part 129 HB4390 - 32 - LRB098 15788 HLH 50821 b 1 of the Federal Aviation Regulations. The changes made to this 2 paragraph (27) by Public Act 98-534 this amendatory Act of the 3 98th General Assembly are declarative of existing law. 4 (28) Tangible personal property purchased by a 5 public-facilities corporation, as described in Section 6 11-65-10 of the Illinois Municipal Code, for purposes of 7 constructing or furnishing a municipal convention hall, but 8 only if the legal title to the municipal convention hall is 9 transferred to the municipality without any further 10 consideration by or on behalf of the municipality at the time 11 of the completion of the municipal convention hall or upon the 12 retirement or redemption of any bonds or other debt instruments 13 issued by the public-facilities corporation in connection with 14 the development of the municipal convention hall. This 15 exemption includes existing public-facilities corporations as 16 provided in Section 11-65-25 of the Illinois Municipal Code. 17 This paragraph is exempt from the provisions of Section 3-75. 18 (29) Medical appliances purchased for use by a person aged 19 65 or older. This paragraph is exempt from the provisions of 20 Section 3-75. 21 (Source: P.A. 97-38, eff. 6-28-11; 97-227, eff. 1-1-12; 97-431, 22 eff. 8-16-11; 97-636, eff. 6-1-12; 97-767, eff. 7-9-12; 98-104, 23 eff. 7-22-13; 98-422, eff. 8-16-13; 98-456, eff. 8-16-13; 24 98-534, eff. 8-23-13; revised 9-9-13.) 25 Section 15. The Service Occupation Tax Act is amended by HB4390 - 33 - LRB098 15788 HLH 50821 b 1 changing Section 3-5 as follows: 2 (35 ILCS 115/3-5) 3 Sec. 3-5. Exemptions. The following tangible personal 4 property is exempt from the tax imposed by this Act: 5 (1) Personal property sold by a corporation, society, 6 association, foundation, institution, or organization, other 7 than a limited liability company, that is organized and 8 operated as a not-for-profit service enterprise for the benefit 9 of persons 65 years of age or older if the personal property 10 was not purchased by the enterprise for the purpose of resale 11 by the enterprise. 12 (2) Personal property purchased by a not-for-profit 13 Illinois county fair association for use in conducting, 14 operating, or promoting the county fair. 15 (3) Personal property purchased by any not-for-profit arts 16 or cultural organization that establishes, by proof required by 17 the Department by rule, that it has received an exemption under 18 Section 501(c)(3) of the Internal Revenue Code and that is 19 organized and operated primarily for the presentation or 20 support of arts or cultural programming, activities, or 21 services. These organizations include, but are not limited to, 22 music and dramatic arts organizations such as symphony 23 orchestras and theatrical groups, arts and cultural service 24 organizations, local arts councils, visual arts organizations, 25 and media arts organizations. On and after the effective date HB4390 - 34 - LRB098 15788 HLH 50821 b 1 of this amendatory Act of the 92nd General Assembly, however, 2 an entity otherwise eligible for this exemption shall not make 3 tax-free purchases unless it has an active identification 4 number issued by the Department. 5 (4) Legal tender, currency, medallions, or gold or silver 6 coinage issued by the State of Illinois, the government of the 7 United States of America, or the government of any foreign 8 country, and bullion. 9 (5) Until July 1, 2003 and beginning again on September 1, 10 2004 through August 30, 2014, graphic arts machinery and 11 equipment, including repair and replacement parts, both new and 12 used, and including that manufactured on special order or 13 purchased for lease, certified by the purchaser to be used 14 primarily for graphic arts production. Equipment includes 15 chemicals or chemicals acting as catalysts but only if the 16 chemicals or chemicals acting as catalysts effect a direct and 17 immediate change upon a graphic arts product. 18 (6) Personal property sold by a teacher-sponsored student 19 organization affiliated with an elementary or secondary school 20 located in Illinois. 21 (7) Farm machinery and equipment, both new and used, 22 including that manufactured on special order, certified by the 23 purchaser to be used primarily for production agriculture or 24 State or federal agricultural programs, including individual 25 replacement parts for the machinery and equipment, including 26 machinery and equipment purchased for lease, and including HB4390 - 35 - LRB098 15788 HLH 50821 b 1 implements of husbandry defined in Section 1-130 of the 2 Illinois Vehicle Code, farm machinery and agricultural 3 chemical and fertilizer spreaders, and nurse wagons required to 4 be registered under Section 3-809 of the Illinois Vehicle Code, 5 but excluding other motor vehicles required to be registered 6 under the Illinois Vehicle Code. Horticultural polyhouses or 7 hoop houses used for propagating, growing, or overwintering 8 plants shall be considered farm machinery and equipment under 9 this item (7). Agricultural chemical tender tanks and dry boxes 10 shall include units sold separately from a motor vehicle 11 required to be licensed and units sold mounted on a motor 12 vehicle required to be licensed if the selling price of the 13 tender is separately stated. 14 Farm machinery and equipment shall include precision 15 farming equipment that is installed or purchased to be 16 installed on farm machinery and equipment including, but not 17 limited to, tractors, harvesters, sprayers, planters, seeders, 18 or spreaders. Precision farming equipment includes, but is not 19 limited to, soil testing sensors, computers, monitors, 20 software, global positioning and mapping systems, and other 21 such equipment. 22 Farm machinery and equipment also includes computers, 23 sensors, software, and related equipment used primarily in the 24 computer-assisted operation of production agriculture 25 facilities, equipment, and activities such as, but not limited 26 to, the collection, monitoring, and correlation of animal and HB4390 - 36 - LRB098 15788 HLH 50821 b 1 crop data for the purpose of formulating animal diets and 2 agricultural chemicals. This item (7) is exempt from the 3 provisions of Section 3-55. 4 (8) Until June 30, 2013, fuel and petroleum products sold 5 to or used by an air common carrier, certified by the carrier 6 to be used for consumption, shipment, or storage in the conduct 7 of its business as an air common carrier, for a flight destined 8 for or returning from a location or locations outside the 9 United States without regard to previous or subsequent domestic 10 stopovers. 11 Beginning July 1, 2013, fuel and petroleum products sold to 12 or used by an air carrier, certified by the carrier to be used 13 for consumption, shipment, or storage in the conduct of its 14 business as an air common carrier, for a flight that (i) is 15 engaged in foreign trade or is engaged in trade between the 16 United States and any of its possessions and (ii) transports at 17 least one individual or package for hire from the city of 18 origination to the city of final destination on the same 19 aircraft, without regard to a change in the flight number of 20 that aircraft. 21 (9) Proceeds of mandatory service charges separately 22 stated on customers' bills for the purchase and consumption of 23 food and beverages, to the extent that the proceeds of the 24 service charge are in fact turned over as tips or as a 25 substitute for tips to the employees who participate directly 26 in preparing, serving, hosting or cleaning up the food or HB4390 - 37 - LRB098 15788 HLH 50821 b 1 beverage function with respect to which the service charge is 2 imposed. 3 (10) Until July 1, 2003, oil field exploration, drilling, 4 and production equipment, including (i) rigs and parts of rigs, 5 rotary rigs, cable tool rigs, and workover rigs, (ii) pipe and 6 tubular goods, including casing and drill strings, (iii) pumps 7 and pump-jack units, (iv) storage tanks and flow lines, (v) any 8 individual replacement part for oil field exploration, 9 drilling, and production equipment, and (vi) machinery and 10 equipment purchased for lease; but excluding motor vehicles 11 required to be registered under the Illinois Vehicle Code. 12 (11) Photoprocessing machinery and equipment, including 13 repair and replacement parts, both new and used, including that 14 manufactured on special order, certified by the purchaser to be 15 used primarily for photoprocessing, and including 16 photoprocessing machinery and equipment purchased for lease. 17 (12) Coal and aggregate exploration, mining, off-highway 18 offhighway hauling, processing, maintenance, and reclamation 19 equipment, including replacement parts and equipment, and 20 including equipment purchased for lease, but excluding motor 21 vehicles required to be registered under the Illinois Vehicle 22 Code. The changes made to this Section by Public Act 97-767 23 apply on and after July 1, 2003, but no claim for credit or 24 refund is allowed on or after August 16, 2013 ( the effective 25 date of Public Act 98-456) this amendatory Act of the 98th 26 General Assembly for such taxes paid during the period HB4390 - 38 - LRB098 15788 HLH 50821 b 1 beginning July 1, 2003 and ending on August 16, 2013 ( the 2 effective date of Public Act 98-456) this amendatory Act of the 3 98th General Assembly . 4 (13) Beginning January 1, 1992 and through June 30, 2016, 5 food for human consumption that is to be consumed off the 6 premises where it is sold (other than alcoholic beverages, soft 7 drinks and food that has been prepared for immediate 8 consumption) and prescription and non-prescription medicines, 9 drugs, medical appliances, and insulin, urine testing 10 materials, syringes, and needles used by diabetics, for human 11 use, when purchased for use by a person receiving medical 12 assistance under Article V of the Illinois Public Aid Code who 13 resides in a licensed long-term care facility, as defined in 14 the Nursing Home Care Act, or in a licensed facility as defined 15 in the ID/DD Community Care Act or the Specialized Mental 16 Health Rehabilitation Act of 2013. 17 (14) Semen used for artificial insemination of livestock 18 for direct agricultural production. 19 (15) Horses, or interests in horses, registered with and 20 meeting the requirements of any of the Arabian Horse Club 21 Registry of America, Appaloosa Horse Club, American Quarter 22 Horse Association, United States Trotting Association, or 23 Jockey Club, as appropriate, used for purposes of breeding or 24 racing for prizes. This item (15) is exempt from the provisions 25 of Section 3-55, and the exemption provided for under this item 26 (15) applies for all periods beginning May 30, 1995, but no HB4390 - 39 - LRB098 15788 HLH 50821 b 1 claim for credit or refund is allowed on or after January 1, 2 2008 (the effective date of Public Act 95-88) for such taxes 3 paid during the period beginning May 30, 2000 and ending on 4 January 1, 2008 (the effective date of Public Act 95-88). 5 (16) Computers and communications equipment utilized for 6 any hospital purpose and equipment used in the diagnosis, 7 analysis, or treatment of hospital patients sold to a lessor 8 who leases the equipment, under a lease of one year or longer 9 executed or in effect at the time of the purchase, to a 10 hospital that has been issued an active tax exemption 11 identification number by the Department under Section 1g of the 12 Retailers' Occupation Tax Act. 13 (17) Personal property sold to a lessor who leases the 14 property, under a lease of one year or longer executed or in 15 effect at the time of the purchase, to a governmental body that 16 has been issued an active tax exemption identification number 17 by the Department under Section 1g of the Retailers' Occupation 18 Tax Act. 19 (18) Beginning with taxable years ending on or after 20 December 31, 1995 and ending with taxable years ending on or 21 before December 31, 2004, personal property that is donated for 22 disaster relief to be used in a State or federally declared 23 disaster area in Illinois or bordering Illinois by a 24 manufacturer or retailer that is registered in this State to a 25 corporation, society, association, foundation, or institution 26 that has been issued a sales tax exemption identification HB4390 - 40 - LRB098 15788 HLH 50821 b 1 number by the Department that assists victims of the disaster 2 who reside within the declared disaster area. 3 (19) Beginning with taxable years ending on or after 4 December 31, 1995 and ending with taxable years ending on or 5 before December 31, 2004, personal property that is used in the 6 performance of infrastructure repairs in this State, including 7 but not limited to municipal roads and streets, access roads, 8 bridges, sidewalks, waste disposal systems, water and sewer 9 line extensions, water distribution and purification 10 facilities, storm water drainage and retention facilities, and 11 sewage treatment facilities, resulting from a State or 12 federally declared disaster in Illinois or bordering Illinois 13 when such repairs are initiated on facilities located in the 14 declared disaster area within 6 months after the disaster. 15 (20) Beginning July 1, 1999, game or game birds sold at a 16 "game breeding and hunting preserve area" as that term is used 17 in the Wildlife Code. This paragraph is exempt from the 18 provisions of Section 3-55. 19 (21) A motor vehicle, as that term is defined in Section 20 1-146 of the Illinois Vehicle Code, that is donated to a 21 corporation, limited liability company, society, association, 22 foundation, or institution that is determined by the Department 23 to be organized and operated exclusively for educational 24 purposes. For purposes of this exemption, "a corporation, 25 limited liability company, society, association, foundation, 26 or institution organized and operated exclusively for HB4390 - 41 - LRB098 15788 HLH 50821 b 1 educational purposes" means all tax-supported public schools, 2 private schools that offer systematic instruction in useful 3 branches of learning by methods common to public schools and 4 that compare favorably in their scope and intensity with the 5 course of study presented in tax-supported schools, and 6 vocational or technical schools or institutes organized and 7 operated exclusively to provide a course of study of not less 8 than 6 weeks duration and designed to prepare individuals to 9 follow a trade or to pursue a manual, technical, mechanical, 10 industrial, business, or commercial occupation. 11 (22) Beginning January 1, 2000, personal property, 12 including food, purchased through fundraising events for the 13 benefit of a public or private elementary or secondary school, 14 a group of those schools, or one or more school districts if 15 the events are sponsored by an entity recognized by the school 16 district that consists primarily of volunteers and includes 17 parents and teachers of the school children. This paragraph 18 does not apply to fundraising events (i) for the benefit of 19 private home instruction or (ii) for which the fundraising 20 entity purchases the personal property sold at the events from 21 another individual or entity that sold the property for the 22 purpose of resale by the fundraising entity and that profits 23 from the sale to the fundraising entity. This paragraph is 24 exempt from the provisions of Section 3-55. 25 (23) Beginning January 1, 2000 and through December 31, 26 2001, new or used automatic vending machines that prepare and HB4390 - 42 - LRB098 15788 HLH 50821 b 1 serve hot food and beverages, including coffee, soup, and other 2 items, and replacement parts for these machines. Beginning 3 January 1, 2002 and through June 30, 2003, machines and parts 4 for machines used in commercial, coin-operated amusement and 5 vending business if a use or occupation tax is paid on the 6 gross receipts derived from the use of the commercial, 7 coin-operated amusement and vending machines. This paragraph 8 is exempt from the provisions of Section 3-55. 9 (24) Beginning on the effective date of this amendatory Act 10 of the 92nd General Assembly, computers and communications 11 equipment utilized for any hospital purpose and equipment used 12 in the diagnosis, analysis, or treatment of hospital patients 13 sold to a lessor who leases the equipment, under a lease of one 14 year or longer executed or in effect at the time of the 15 purchase, to a hospital that has been issued an active tax 16 exemption identification number by the Department under 17 Section 1g of the Retailers' Occupation Tax Act. This paragraph 18 is exempt from the provisions of Section 3-55. 19 (25) Beginning on the effective date of this amendatory Act 20 of the 92nd General Assembly, personal property sold to a 21 lessor who leases the property, under a lease of one year or 22 longer executed or in effect at the time of the purchase, to a 23 governmental body that has been issued an active tax exemption 24 identification number by the Department under Section 1g of the 25 Retailers' Occupation Tax Act. This paragraph is exempt from 26 the provisions of Section 3-55. HB4390 - 43 - LRB098 15788 HLH 50821 b 1 (26) Beginning on January 1, 2002 and through June 30, 2 2016, tangible personal property purchased from an Illinois 3 retailer by a taxpayer engaged in centralized purchasing 4 activities in Illinois who will, upon receipt of the property 5 in Illinois, temporarily store the property in Illinois (i) for 6 the purpose of subsequently transporting it outside this State 7 for use or consumption thereafter solely outside this State or 8 (ii) for the purpose of being processed, fabricated, or 9 manufactured into, attached to, or incorporated into other 10 tangible personal property to be transported outside this State 11 and thereafter used or consumed solely outside this State. The 12 Director of Revenue shall, pursuant to rules adopted in 13 accordance with the Illinois Administrative Procedure Act, 14 issue a permit to any taxpayer in good standing with the 15 Department who is eligible for the exemption under this 16 paragraph (26). The permit issued under this paragraph (26) 17 shall authorize the holder, to the extent and in the manner 18 specified in the rules adopted under this Act, to purchase 19 tangible personal property from a retailer exempt from the 20 taxes imposed by this Act. Taxpayers shall maintain all 21 necessary books and records to substantiate the use and 22 consumption of all such tangible personal property outside of 23 the State of Illinois. 24 (27) Beginning January 1, 2008, tangible personal property 25 used in the construction or maintenance of a community water 26 supply, as defined under Section 3.145 of the Environmental HB4390 - 44 - LRB098 15788 HLH 50821 b 1 Protection Act, that is operated by a not-for-profit 2 corporation that holds a valid water supply permit issued under 3 Title IV of the Environmental Protection Act. This paragraph is 4 exempt from the provisions of Section 3-55. 5 (28) Tangible personal property sold to a 6 public-facilities corporation, as described in Section 7 11-65-10 of the Illinois Municipal Code, for purposes of 8 constructing or furnishing a municipal convention hall, but 9 only if the legal title to the municipal convention hall is 10 transferred to the municipality without any further 11 consideration by or on behalf of the municipality at the time 12 of the completion of the municipal convention hall or upon the 13 retirement or redemption of any bonds or other debt instruments 14 issued by the public-facilities corporation in connection with 15 the development of the municipal convention hall. This 16 exemption includes existing public-facilities corporations as 17 provided in Section 11-65-25 of the Illinois Municipal Code. 18 This paragraph is exempt from the provisions of Section 3-55. 19 (29) Beginning January 1, 2010, materials, parts, 20 equipment, components, and furnishings incorporated into or 21 upon an aircraft as part of the modification, refurbishment, 22 completion, replacement, repair, or maintenance of the 23 aircraft. This exemption includes consumable supplies used in 24 the modification, refurbishment, completion, replacement, 25 repair, and maintenance of aircraft, but excludes any 26 materials, parts, equipment, components, and consumable HB4390 - 45 - LRB098 15788 HLH 50821 b 1 supplies used in the modification, replacement, repair, and 2 maintenance of aircraft engines or power plants, whether such 3 engines or power plants are installed or uninstalled upon any 4 such aircraft. "Consumable supplies" include, but are not 5 limited to, adhesive, tape, sandpaper, general purpose 6 lubricants, cleaning solution, latex gloves, and protective 7 films. This exemption applies only to the transfer of 8 qualifying tangible personal property incident to the 9 modification, refurbishment, completion, replacement, repair, 10 or maintenance of an aircraft by persons who (i) hold an Air 11 Agency Certificate and are empowered to operate an approved 12 repair station by the Federal Aviation Administration, (ii) 13 have a Class IV Rating, and (iii) conduct operations in 14 accordance with Part 145 of the Federal Aviation Regulations. 15 The exemption does not include aircraft operated by a 16 commercial air carrier providing scheduled passenger air 17 service pursuant to authority issued under Part 121 or Part 129 18 of the Federal Aviation Regulations. The changes made to this 19 paragraph (29) by Public Act 98-534 this amendatory Act of the 20 98th General Assembly are declarative of existing law. 21 (30) Medical appliances purchased for use by a person aged 22 65 or older. This paragraph is exempt from the provisions of 23 Section 3-55. 24 (Source: P.A. 97-38, eff. 6-28-11; 97-73, eff. 6-30-11; 97-227, 25 eff. 1-1-12; 97-431, eff. 8-16-11; 97-636, eff. 6-1-12; 97-767, 26 eff. 7-9-12; 98-104, eff. 7-22-13; 98-422, eff. 8-16-13; HB4390 - 46 - LRB098 15788 HLH 50821 b 1 98-456, eff. 8-16-13; 98-534, eff. 8-23-13; revised 9-9-13.) 2 Section 20. The Retailers' Occupation Tax Act is amended by 3 changing Section 2-5 as follows: 4 (35 ILCS 120/2-5) 5 Sec. 2-5. Exemptions. Gross receipts from proceeds from the 6 sale of the following tangible personal property are exempt 7 from the tax imposed by this Act: 8 (1) Farm chemicals. 9 (2) Farm machinery and equipment, both new and used, 10 including that manufactured on special order, certified by the 11 purchaser to be used primarily for production agriculture or 12 State or federal agricultural programs, including individual 13 replacement parts for the machinery and equipment, including 14 machinery and equipment purchased for lease, and including 15 implements of husbandry defined in Section 1-130 of the 16 Illinois Vehicle Code, farm machinery and agricultural 17 chemical and fertilizer spreaders, and nurse wagons required to 18 be registered under Section 3-809 of the Illinois Vehicle Code, 19 but excluding other motor vehicles required to be registered 20 under the Illinois Vehicle Code. Horticultural polyhouses or 21 hoop houses used for propagating, growing, or overwintering 22 plants shall be considered farm machinery and equipment under 23 this item (2). Agricultural chemical tender tanks and dry boxes 24 shall include units sold separately from a motor vehicle HB4390 - 47 - LRB098 15788 HLH 50821 b 1 required to be licensed and units sold mounted on a motor 2 vehicle required to be licensed, if the selling price of the 3 tender is separately stated. 4 Farm machinery and equipment shall include precision 5 farming equipment that is installed or purchased to be 6 installed on farm machinery and equipment including, but not 7 limited to, tractors, harvesters, sprayers, planters, seeders, 8 or spreaders. Precision farming equipment includes, but is not 9 limited to, soil testing sensors, computers, monitors, 10 software, global positioning and mapping systems, and other 11 such equipment. 12 Farm machinery and equipment also includes computers, 13 sensors, software, and related equipment used primarily in the 14 computer-assisted operation of production agriculture 15 facilities, equipment, and activities such as, but not limited 16 to, the collection, monitoring, and correlation of animal and 17 crop data for the purpose of formulating animal diets and 18 agricultural chemicals. This item (2) is exempt from the 19 provisions of Section 2-70. 20 (3) Until July 1, 2003, distillation machinery and 21 equipment, sold as a unit or kit, assembled or installed by the 22 retailer, certified by the user to be used only for the 23 production of ethyl alcohol that will be used for consumption 24 as motor fuel or as a component of motor fuel for the personal 25 use of the user, and not subject to sale or resale. 26 (4) Until July 1, 2003 and beginning again September 1, HB4390 - 48 - LRB098 15788 HLH 50821 b 1 2004 through August 30, 2014, graphic arts machinery and 2 equipment, including repair and replacement parts, both new and 3 used, and including that manufactured on special order or 4 purchased for lease, certified by the purchaser to be used 5 primarily for graphic arts production. Equipment includes 6 chemicals or chemicals acting as catalysts but only if the 7 chemicals or chemicals acting as catalysts effect a direct and 8 immediate change upon a graphic arts product. 9 (5) A motor vehicle that is used for automobile renting, as 10 defined in the Automobile Renting Occupation and Use Tax Act. 11 This paragraph is exempt from the provisions of Section 2-70. 12 (6) Personal property sold by a teacher-sponsored student 13 organization affiliated with an elementary or secondary school 14 located in Illinois. 15 (7) Until July 1, 2003, proceeds of that portion of the 16 selling price of a passenger car the sale of which is subject 17 to the Replacement Vehicle Tax. 18 (8) Personal property sold to an Illinois county fair 19 association for use in conducting, operating, or promoting the 20 county fair. 21 (9) Personal property sold to a not-for-profit arts or 22 cultural organization that establishes, by proof required by 23 the Department by rule, that it has received an exemption under 24 Section 501(c)(3) of the Internal Revenue Code and that is 25 organized and operated primarily for the presentation or 26 support of arts or cultural programming, activities, or HB4390 - 49 - LRB098 15788 HLH 50821 b 1 services. These organizations include, but are not limited to, 2 music and dramatic arts organizations such as symphony 3 orchestras and theatrical groups, arts and cultural service 4 organizations, local arts councils, visual arts organizations, 5 and media arts organizations. On and after the effective date 6 of this amendatory Act of the 92nd General Assembly, however, 7 an entity otherwise eligible for this exemption shall not make 8 tax-free purchases unless it has an active identification 9 number issued by the Department. 10 (10) Personal property sold by a corporation, society, 11 association, foundation, institution, or organization, other 12 than a limited liability company, that is organized and 13 operated as a not-for-profit service enterprise for the benefit 14 of persons 65 years of age or older if the personal property 15 was not purchased by the enterprise for the purpose of resale 16 by the enterprise. 17 (11) Personal property sold to a governmental body, to a 18 corporation, society, association, foundation, or institution 19 organized and operated exclusively for charitable, religious, 20 or educational purposes, or to a not-for-profit corporation, 21 society, association, foundation, institution, or organization 22 that has no compensated officers or employees and that is 23 organized and operated primarily for the recreation of persons 24 55 years of age or older. A limited liability company may 25 qualify for the exemption under this paragraph only if the 26 limited liability company is organized and operated HB4390 - 50 - LRB098 15788 HLH 50821 b 1 exclusively for educational purposes. On and after July 1, 2 1987, however, no entity otherwise eligible for this exemption 3 shall make tax-free purchases unless it has an active 4 identification number issued by the Department. 5 (12) Tangible personal property sold to interstate 6 carriers for hire for use as rolling stock moving in interstate 7 commerce or to lessors under leases of one year or longer 8 executed or in effect at the time of purchase by interstate 9 carriers for hire for use as rolling stock moving in interstate 10 commerce and equipment operated by a telecommunications 11 provider, licensed as a common carrier by the Federal 12 Communications Commission, which is permanently installed in 13 or affixed to aircraft moving in interstate commerce. 14 (12-5) On and after July 1, 2003 and through June 30, 2004, 15 motor vehicles of the second division with a gross vehicle 16 weight in excess of 8,000 pounds that are subject to the 17 commercial distribution fee imposed under Section 3-815.1 of 18 the Illinois Vehicle Code. Beginning on July 1, 2004 and 19 through June 30, 2005, the use in this State of motor vehicles 20 of the second division: (i) with a gross vehicle weight rating 21 in excess of 8,000 pounds; (ii) that are subject to the 22 commercial distribution fee imposed under Section 3-815.1 of 23 the Illinois Vehicle Code; and (iii) that are primarily used 24 for commercial purposes. Through June 30, 2005, this exemption 25 applies to repair and replacement parts added after the initial 26 purchase of such a motor vehicle if that motor vehicle is used HB4390 - 51 - LRB098 15788 HLH 50821 b 1 in a manner that would qualify for the rolling stock exemption 2 otherwise provided for in this Act. For purposes of this 3 paragraph, "used for commercial purposes" means the 4 transportation of persons or property in furtherance of any 5 commercial or industrial enterprise whether for-hire or not. 6 (13) Proceeds from sales to owners, lessors, or shippers of 7 tangible personal property that is utilized by interstate 8 carriers for hire for use as rolling stock moving in interstate 9 commerce and equipment operated by a telecommunications 10 provider, licensed as a common carrier by the Federal 11 Communications Commission, which is permanently installed in 12 or affixed to aircraft moving in interstate commerce. 13 (14) Machinery and equipment that will be used by the 14 purchaser, or a lessee of the purchaser, primarily in the 15 process of manufacturing or assembling tangible personal 16 property for wholesale or retail sale or lease, whether the 17 sale or lease is made directly by the manufacturer or by some 18 other person, whether the materials used in the process are 19 owned by the manufacturer or some other person, or whether the 20 sale or lease is made apart from or as an incident to the 21 seller's engaging in the service occupation of producing 22 machines, tools, dies, jigs, patterns, gauges, or other similar 23 items of no commercial value on special order for a particular 24 purchaser. The exemption provided by this paragraph (14) does 25 not include machinery and equipment used in (i) the generation 26 of electricity for wholesale or retail sale; (ii) the HB4390 - 52 - LRB098 15788 HLH 50821 b 1 generation or treatment of natural or artificial gas for 2 wholesale or retail sale that is delivered to customers through 3 pipes, pipelines, or mains; or (iii) the treatment of water for 4 wholesale or retail sale that is delivered to customers through 5 pipes, pipelines, or mains. The provisions of Public Act 98-583 6 this amendatory Act of the 98th General Assembly are 7 declaratory of existing law as to the meaning and scope of this 8 exemption. 9 (15) Proceeds of mandatory service charges separately 10 stated on customers' bills for purchase and consumption of food 11 and beverages, to the extent that the proceeds of the service 12 charge are in fact turned over as tips or as a substitute for 13 tips to the employees who participate directly in preparing, 14 serving, hosting or cleaning up the food or beverage function 15 with respect to which the service charge is imposed. 16 (16) Petroleum products sold to a purchaser if the seller 17 is prohibited by federal law from charging tax to the 18 purchaser. 19 (17) Tangible personal property sold to a common carrier by 20 rail or motor that receives the physical possession of the 21 property in Illinois and that transports the property, or 22 shares with another common carrier in the transportation of the 23 property, out of Illinois on a standard uniform bill of lading 24 showing the seller of the property as the shipper or consignor 25 of the property to a destination outside Illinois, for use 26 outside Illinois. HB4390 - 53 - LRB098 15788 HLH 50821 b 1 (18) Legal tender, currency, medallions, or gold or silver 2 coinage issued by the State of Illinois, the government of the 3 United States of America, or the government of any foreign 4 country, and bullion. 5 (19) Until July 1 2003, oil field exploration, drilling, 6 and production equipment, including (i) rigs and parts of rigs, 7 rotary rigs, cable tool rigs, and workover rigs, (ii) pipe and 8 tubular goods, including casing and drill strings, (iii) pumps 9 and pump-jack units, (iv) storage tanks and flow lines, (v) any 10 individual replacement part for oil field exploration, 11 drilling, and production equipment, and (vi) machinery and 12 equipment purchased for lease; but excluding motor vehicles 13 required to be registered under the Illinois Vehicle Code. 14 (20) Photoprocessing machinery and equipment, including 15 repair and replacement parts, both new and used, including that 16 manufactured on special order, certified by the purchaser to be 17 used primarily for photoprocessing, and including 18 photoprocessing machinery and equipment purchased for lease. 19 (21) Coal and aggregate exploration, mining, off-highway 20 offhighway hauling, processing, maintenance, and reclamation 21 equipment, including replacement parts and equipment, and 22 including equipment purchased for lease, but excluding motor 23 vehicles required to be registered under the Illinois Vehicle 24 Code. The changes made to this Section by Public Act 97-767 25 apply on and after July 1, 2003, but no claim for credit or 26 refund is allowed on or after August 16, 2013 ( the effective HB4390 - 54 - LRB098 15788 HLH 50821 b 1 date of Public Act 98-456) this amendatory Act of the 98th 2 General Assembly for such taxes paid during the period 3 beginning July 1, 2003 and ending on August 16, 2013 ( the 4 effective date of Public Act 98-456) this amendatory Act of the 5 98th General Assembly . 6 (22) Until June 30, 2013, fuel and petroleum products sold 7 to or used by an air carrier, certified by the carrier to be 8 used for consumption, shipment, or storage in the conduct of 9 its business as an air common carrier, for a flight destined 10 for or returning from a location or locations outside the 11 United States without regard to previous or subsequent domestic 12 stopovers. 13 Beginning July 1, 2013, fuel and petroleum products sold to 14 or used by an air carrier, certified by the carrier to be used 15 for consumption, shipment, or storage in the conduct of its 16 business as an air common carrier, for a flight that (i) is 17 engaged in foreign trade or is engaged in trade between the 18 United States and any of its possessions and (ii) transports at 19 least one individual or package for hire from the city of 20 origination to the city of final destination on the same 21 aircraft, without regard to a change in the flight number of 22 that aircraft. 23 (23) A transaction in which the purchase order is received 24 by a florist who is located outside Illinois, but who has a 25 florist located in Illinois deliver the property to the 26 purchaser or the purchaser's donee in Illinois. HB4390 - 55 - LRB098 15788 HLH 50821 b 1 (24) Fuel consumed or used in the operation of ships, 2 barges, or vessels that are used primarily in or for the 3 transportation of property or the conveyance of persons for 4 hire on rivers bordering on this State if the fuel is delivered 5 by the seller to the purchaser's barge, ship, or vessel while 6 it is afloat upon that bordering river. 7 (25) Except as provided in item (25-5) of this Section, a 8 motor vehicle sold in this State to a nonresident even though 9 the motor vehicle is delivered to the nonresident in this 10 State, if the motor vehicle is not to be titled in this State, 11 and if a drive-away permit is issued to the motor vehicle as 12 provided in Section 3-603 of the Illinois Vehicle Code or if 13 the nonresident purchaser has vehicle registration plates to 14 transfer to the motor vehicle upon returning to his or her home 15 state. The issuance of the drive-away permit or having the 16 out-of-state registration plates to be transferred is prima 17 facie evidence that the motor vehicle will not be titled in 18 this State. 19 (25-5) The exemption under item (25) does not apply if the 20 state in which the motor vehicle will be titled does not allow 21 a reciprocal exemption for a motor vehicle sold and delivered 22 in that state to an Illinois resident but titled in Illinois. 23 The tax collected under this Act on the sale of a motor vehicle 24 in this State to a resident of another state that does not 25 allow a reciprocal exemption shall be imposed at a rate equal 26 to the state's rate of tax on taxable property in the state in HB4390 - 56 - LRB098 15788 HLH 50821 b 1 which the purchaser is a resident, except that the tax shall 2 not exceed the tax that would otherwise be imposed under this 3 Act. At the time of the sale, the purchaser shall execute a 4 statement, signed under penalty of perjury, of his or her 5 intent to title the vehicle in the state in which the purchaser 6 is a resident within 30 days after the sale and of the fact of 7 the payment to the State of Illinois of tax in an amount 8 equivalent to the state's rate of tax on taxable property in 9 his or her state of residence and shall submit the statement to 10 the appropriate tax collection agency in his or her state of 11 residence. In addition, the retailer must retain a signed copy 12 of the statement in his or her records. Nothing in this item 13 shall be construed to require the removal of the vehicle from 14 this state following the filing of an intent to title the 15 vehicle in the purchaser's state of residence if the purchaser 16 titles the vehicle in his or her state of residence within 30 17 days after the date of sale. The tax collected under this Act 18 in accordance with this item (25-5) shall be proportionately 19 distributed as if the tax were collected at the 6.25% general 20 rate imposed under this Act. 21 (25-7) Beginning on July 1, 2007, no tax is imposed under 22 this Act on the sale of an aircraft, as defined in Section 3 of 23 the Illinois Aeronautics Act, if all of the following 24 conditions are met: 25 (1) the aircraft leaves this State within 15 days after 26 the later of either the issuance of the final billing for HB4390 - 57 - LRB098 15788 HLH 50821 b 1 the sale of the aircraft, or the authorized approval for 2 return to service, completion of the maintenance record 3 entry, and completion of the test flight and ground test 4 for inspection, as required by 14 C.F.R. 91.407; 5 (2) the aircraft is not based or registered in this 6 State after the sale of the aircraft; and 7 (3) the seller retains in his or her books and records 8 and provides to the Department a signed and dated 9 certification from the purchaser, on a form prescribed by 10 the Department, certifying that the requirements of this 11 item (25-7) are met. The certificate must also include the 12 name and address of the purchaser, the address of the 13 location where the aircraft is to be titled or registered, 14 the address of the primary physical location of the 15 aircraft, and other information that the Department may 16 reasonably require. 17 For purposes of this item (25-7): 18 "Based in this State" means hangared, stored, or otherwise 19 used, excluding post-sale customizations as defined in this 20 Section, for 10 or more days in each 12-month period 21 immediately following the date of the sale of the aircraft. 22 "Registered in this State" means an aircraft registered 23 with the Department of Transportation, Aeronautics Division, 24 or titled or registered with the Federal Aviation 25 Administration to an address located in this State. 26 This paragraph (25-7) is exempt from the provisions of HB4390 - 58 - LRB098 15788 HLH 50821 b 1 Section 2-70. 2 (26) Semen used for artificial insemination of livestock 3 for direct agricultural production. 4 (27) Horses, or interests in horses, registered with and 5 meeting the requirements of any of the Arabian Horse Club 6 Registry of America, Appaloosa Horse Club, American Quarter 7 Horse Association, United States Trotting Association, or 8 Jockey Club, as appropriate, used for purposes of breeding or 9 racing for prizes. This item (27) is exempt from the provisions 10 of Section 2-70, and the exemption provided for under this item 11 (27) applies for all periods beginning May 30, 1995, but no 12 claim for credit or refund is allowed on or after January 1, 13 2008 (the effective date of Public Act 95-88) for such taxes 14 paid during the period beginning May 30, 2000 and ending on 15 January 1, 2008 (the effective date of Public Act 95-88). 16 (28) Computers and communications equipment utilized for 17 any hospital purpose and equipment used in the diagnosis, 18 analysis, or treatment of hospital patients sold to a lessor 19 who leases the equipment, under a lease of one year or longer 20 executed or in effect at the time of the purchase, to a 21 hospital that has been issued an active tax exemption 22 identification number by the Department under Section 1g of 23 this Act. 24 (29) Personal property sold to a lessor who leases the 25 property, under a lease of one year or longer executed or in 26 effect at the time of the purchase, to a governmental body that HB4390 - 59 - LRB098 15788 HLH 50821 b 1 has been issued an active tax exemption identification number 2 by the Department under Section 1g of this Act. 3 (30) Beginning with taxable years ending on or after 4 December 31, 1995 and ending with taxable years ending on or 5 before December 31, 2004, personal property that is donated for 6 disaster relief to be used in a State or federally declared 7 disaster area in Illinois or bordering Illinois by a 8 manufacturer or retailer that is registered in this State to a 9 corporation, society, association, foundation, or institution 10 that has been issued a sales tax exemption identification 11 number by the Department that assists victims of the disaster 12 who reside within the declared disaster area. 13 (31) Beginning with taxable years ending on or after 14 December 31, 1995 and ending with taxable years ending on or 15 before December 31, 2004, personal property that is used in the 16 performance of infrastructure repairs in this State, including 17 but not limited to municipal roads and streets, access roads, 18 bridges, sidewalks, waste disposal systems, water and sewer 19 line extensions, water distribution and purification 20 facilities, storm water drainage and retention facilities, and 21 sewage treatment facilities, resulting from a State or 22 federally declared disaster in Illinois or bordering Illinois 23 when such repairs are initiated on facilities located in the 24 declared disaster area within 6 months after the disaster. 25 (32) Beginning July 1, 1999, game or game birds sold at a 26 "game breeding and hunting preserve area" as that term is used HB4390 - 60 - LRB098 15788 HLH 50821 b 1 in the Wildlife Code. This paragraph is exempt from the 2 provisions of Section 2-70. 3 (33) A motor vehicle, as that term is defined in Section 4 1-146 of the Illinois Vehicle Code, that is donated to a 5 corporation, limited liability company, society, association, 6 foundation, or institution that is determined by the Department 7 to be organized and operated exclusively for educational 8 purposes. For purposes of this exemption, "a corporation, 9 limited liability company, society, association, foundation, 10 or institution organized and operated exclusively for 11 educational purposes" means all tax-supported public schools, 12 private schools that offer systematic instruction in useful 13 branches of learning by methods common to public schools and 14 that compare favorably in their scope and intensity with the 15 course of study presented in tax-supported schools, and 16 vocational or technical schools or institutes organized and 17 operated exclusively to provide a course of study of not less 18 than 6 weeks duration and designed to prepare individuals to 19 follow a trade or to pursue a manual, technical, mechanical, 20 industrial, business, or commercial occupation. 21 (34) Beginning January 1, 2000, personal property, 22 including food, purchased through fundraising events for the 23 benefit of a public or private elementary or secondary school, 24 a group of those schools, or one or more school districts if 25 the events are sponsored by an entity recognized by the school 26 district that consists primarily of volunteers and includes HB4390 - 61 - LRB098 15788 HLH 50821 b 1 parents and teachers of the school children. This paragraph 2 does not apply to fundraising events (i) for the benefit of 3 private home instruction or (ii) for which the fundraising 4 entity purchases the personal property sold at the events from 5 another individual or entity that sold the property for the 6 purpose of resale by the fundraising entity and that profits 7 from the sale to the fundraising entity. This paragraph is 8 exempt from the provisions of Section 2-70. 9 (35) Beginning January 1, 2000 and through December 31, 10 2001, new or used automatic vending machines that prepare and 11 serve hot food and beverages, including coffee, soup, and other 12 items, and replacement parts for these machines. Beginning 13 January 1, 2002 and through June 30, 2003, machines and parts 14 for machines used in commercial, coin-operated amusement and 15 vending business if a use or occupation tax is paid on the 16 gross receipts derived from the use of the commercial, 17 coin-operated amusement and vending machines. This paragraph 18 is exempt from the provisions of Section 2-70. 19 (35-5) Beginning August 23, 2001 and through June 30, 2016, 20 food for human consumption that is to be consumed off the 21 premises where it is sold (other than alcoholic beverages, soft 22 drinks, and food that has been prepared for immediate 23 consumption) and prescription and nonprescription medicines, 24 drugs, medical appliances, and insulin, urine testing 25 materials, syringes, and needles used by diabetics, for human 26 use, when purchased for use by a person receiving medical HB4390 - 62 - LRB098 15788 HLH 50821 b 1 assistance under Article V of the Illinois Public Aid Code who 2 resides in a licensed long-term care facility, as defined in 3 the Nursing Home Care Act, or a licensed facility as defined in 4 the ID/DD Community Care Act or the Specialized Mental Health 5 Rehabilitation Act of 2013. 6 (36) Beginning August 2, 2001, computers and 7 communications equipment utilized for any hospital purpose and 8 equipment used in the diagnosis, analysis, or treatment of 9 hospital patients sold to a lessor who leases the equipment, 10 under a lease of one year or longer executed or in effect at 11 the time of the purchase, to a hospital that has been issued an 12 active tax exemption identification number by the Department 13 under Section 1g of this Act. This paragraph is exempt from the 14 provisions of Section 2-70. 15 (37) Beginning August 2, 2001, personal property sold to a 16 lessor who leases the property, under a lease of one year or 17 longer executed or in effect at the time of the purchase, to a 18 governmental body that has been issued an active tax exemption 19 identification number by the Department under Section 1g of 20 this Act. This paragraph is exempt from the provisions of 21 Section 2-70. 22 (38) Beginning on January 1, 2002 and through June 30, 23 2016, tangible personal property purchased from an Illinois 24 retailer by a taxpayer engaged in centralized purchasing 25 activities in Illinois who will, upon receipt of the property 26 in Illinois, temporarily store the property in Illinois (i) for HB4390 - 63 - LRB098 15788 HLH 50821 b 1 the purpose of subsequently transporting it outside this State 2 for use or consumption thereafter solely outside this State or 3 (ii) for the purpose of being processed, fabricated, or 4 manufactured into, attached to, or incorporated into other 5 tangible personal property to be transported outside this State 6 and thereafter used or consumed solely outside this State. The 7 Director of Revenue shall, pursuant to rules adopted in 8 accordance with the Illinois Administrative Procedure Act, 9 issue a permit to any taxpayer in good standing with the 10 Department who is eligible for the exemption under this 11 paragraph (38). The permit issued under this paragraph (38) 12 shall authorize the holder, to the extent and in the manner 13 specified in the rules adopted under this Act, to purchase 14 tangible personal property from a retailer exempt from the 15 taxes imposed by this Act. Taxpayers shall maintain all 16 necessary books and records to substantiate the use and 17 consumption of all such tangible personal property outside of 18 the State of Illinois. 19 (39) Beginning January 1, 2008, tangible personal property 20 used in the construction or maintenance of a community water 21 supply, as defined under Section 3.145 of the Environmental 22 Protection Act, that is operated by a not-for-profit 23 corporation that holds a valid water supply permit issued under 24 Title IV of the Environmental Protection Act. This paragraph is 25 exempt from the provisions of Section 2-70. 26 (40) Beginning January 1, 2010, materials, parts, HB4390 - 64 - LRB098 15788 HLH 50821 b 1 equipment, components, and furnishings incorporated into or 2 upon an aircraft as part of the modification, refurbishment, 3 completion, replacement, repair, or maintenance of the 4 aircraft. This exemption includes consumable supplies used in 5 the modification, refurbishment, completion, replacement, 6 repair, and maintenance of aircraft, but excludes any 7 materials, parts, equipment, components, and consumable 8 supplies used in the modification, replacement, repair, and 9 maintenance of aircraft engines or power plants, whether such 10 engines or power plants are installed or uninstalled upon any 11 such aircraft. "Consumable supplies" include, but are not 12 limited to, adhesive, tape, sandpaper, general purpose 13 lubricants, cleaning solution, latex gloves, and protective 14 films. This exemption applies only to the sale of qualifying 15 tangible personal property to persons who modify, refurbish, 16 complete, replace, or maintain an aircraft and who (i) hold an 17 Air Agency Certificate and are empowered to operate an approved 18 repair station by the Federal Aviation Administration, (ii) 19 have a Class IV Rating, and (iii) conduct operations in 20 accordance with Part 145 of the Federal Aviation Regulations. 21 The exemption does not include aircraft operated by a 22 commercial air carrier providing scheduled passenger air 23 service pursuant to authority issued under Part 121 or Part 129 24 of the Federal Aviation Regulations. The changes made to this 25 paragraph (40) by Public Act 98-534 this amendatory Act of the 26 98th General Assembly are declarative of existing law. HB4390 - 65 - LRB098 15788 HLH 50821 b 1 (41) Tangible personal property sold to a 2 public-facilities corporation, as described in Section 3 11-65-10 of the Illinois Municipal Code, for purposes of 4 constructing or furnishing a municipal convention hall, but 5 only if the legal title to the municipal convention hall is 6 transferred to the municipality without any further 7 consideration by or on behalf of the municipality at the time 8 of the completion of the municipal convention hall or upon the 9 retirement or redemption of any bonds or other debt instruments 10 issued by the public-facilities corporation in connection with 11 the development of the municipal convention hall. This 12 exemption includes existing public-facilities corporations as 13 provided in Section 11-65-25 of the Illinois Municipal Code. 14 This paragraph is exempt from the provisions of Section 2-70. 15 (42) Medical appliances purchased for use by a person aged 16 65 or older. This paragraph is exempt from the provisions of 17 Section 2-70. 18 (Source: P.A. 97-38, eff. 6-28-11; 97-73, eff. 6-30-11; 97-227, 19 eff. 1-1-12; 97-431, eff. 8-16-11; 97-636, eff. 6-1-12; 97-767, 20 eff. 7-9-12; 98-104, eff. 7-22-13; 98-422, eff. 8-16-13; 21 98-456, eff. 8-16-13; 98-534, eff. 8-23-13; 98-574, eff. 22 1-1-14; 98-583, eff. 1-1-14; revised 9-9-13.)
https://www.ilga.gov/legislation/98/HB/09800HB4390.htm
Noradrenaline inhibits neurogenic propulsive motor patterns but not neurogenic segmenting haustral progression in the rabbit colon | Request PDF Request PDF | Noradrenaline inhibits neurogenic propulsive motor patterns but not neurogenic segmenting haustral progression in the rabbit colon | Background Excessive sympathetic inhibition may be a cause of colon motor dysfunction. Our aim was to better understand the mechanisms of... | Find, read and cite all the research you need on ResearchGate Noradrenaline inhibits neurogenic propulsive motor patterns but not neurogenic segmenting haustral progression in the rabbit colon February 2019 Neurogastroenterology and Motility 31(Suppl. 1) DOI: 10.1111/nmo.13567 Request full-text Abstract Background Excessive sympathetic inhibition may be a cause of colon motor dysfunction. Our aim was to better understand the mechanisms of sympathetic inhibition on colonic motor patterns using the rabbit colon, hypothesizing that noradrenaline selectively inhibits propulsive motor patterns. Methods Changes in motor patterns of the rabbit colon were studied ex vivo using noradrenaline and adrenoceptor antagonists and analyzed using spatiotemporal diameter maps. Key Results Noradrenaline abolished propulsive contractions: it abolished the long‐distance contractions (LDCs) from a baseline frequency of 0.8 ± 0.3 and the clusters of fast propagating contractions (FPCs) at a frequency of 14.4 ± 2.8 cpm. Both motor patterns recovered after addition of the α2‐adrenoceptor antagonist yohimbine to a frequency of 0.5 ± 0.2 and 9.9 ± 3.3 cpm, respectively. The β‐adrenoceptor antagonist propranolol did not prevent the loss of propulsive motor patterns with noradrenaline. Noradrenaline did not inhibit haustral boundary contractions and increased the frequency of the myogenic ripples from 8.3 ± 1.4 to 10.5 ± 1.3 cpm which was not affected by yohimbine, propranolol nor the α1‐adrenoceptor blocker prazosin. Conclusions and Inferences Noradrenergic inhibition of propulsive motor patterns is mediated by the α2‐adrenoceptor to inhibit the neurogenic LDCs and the neurogenic clustering of FPCs. The neurogenic haustral boundary contractions are not affected, suggesting that α2‐receptors are on selective neural circuits. The excitatory effect of noradrenaline on ripples may be due to the activation of adrenoceptors on interstitial cells of Cajal, but action on α1‐receptors was excluded. No role for the β‐adrenoceptor was found. ... Inflammatory, pharmacological, and cellular factors are thought to contribute to ACPO, though excessive sympathetic drive and/or reduced parasympathetic activity appear to be a common pathophysiological pathway (Wells et al., 2017). Overactive noradrenergic signaling may suppress neurogenic HAPS, and unmask intrinsic pacemaker activity in the distal colon (Hanman et al., 2019; Rosli et al., 2020). No HAPS were observed in 24 h of manometric recordings from this patient, although events may have been missed due to the distal location of the manometry catheter. ... A novel mechanism for acute colonic pseudo-obstruction revealed by high-resolution manometry: A case report Article Full-text available Jul 2021 Cameron Wells Nira Paskaranandavadivel Peng Du Gregory O'Grady Background: Acute colonic pseudo-obstruction (ACPO) is a severe form of colonic dysmotility and is associated with considerable morbidity. The pathophysiology of ACPO is considered to be multifactorial but has not been clarified. Although colonic motility is commonly assumed to be hypoactive, there is little direct pathophysiologi- cal evidence to support this claim. Methods: A 56-year-old woman who developed ACPO following spinal surgery un- derwent 24 h of continuous high-resolution colonic manometry (1 cm resolution over 36 cm) following endoscopic decompression. Manometry data were analyzed and correlated with a three-dimensional colonic model developed from computed tomog- raphy (CT) imaging. Results: The distal colon was found to be profoundly hyperactive, showing near- continuous non-propagating motor activity. Dominant frequencies at 2–6 and 8–12 cycles per minute were observed. The activity was often dissociated and out-of-phase across adjacent regions. The mean amplitude of motor activity was higher than that reported from pre- and post-prandial healthy controls. Correlation with CT imag- ing suggested that these disordered hyperactive motility sequences might act as a functional pseudo-obstruction in the distal colon resulting in secondary proximal dilatation. Conclusions: This is the first detailed description of motility patterns in ACPO and suggests a novel underlying disease mechanism, warranting further investigation and identification of potential therapeutic targets. ... Propulsive activity in the rabbit colon takes the form of the Colonic Motor Complexes (CMCs) (15, 24, 33,39,45). The development of the CMC occurs in a dose-dependent and antagonist sensitive manner, manifested in various levels of excitation beginning with clusters of fast propagating contractions followed by long distance contractions (LDCs) as the most forceful representation of the CMC in the rabbit. ... Intraluminal Prucalopride Increases Propulsive Motor Activities in the Human Colon Preprint May 2020 Mitra Shokrollahi Xuan Yu Wang Natalija Milkova Ji Hong Chen Background: Luminal application of 5-HT4 receptor agonists can increase peristalsis in the guinea pig, mouse, rat and rabbit colon. Our aim in the present study was to test the effects of intraluminal prucalopride on motor patterns in the human colon. Methods: Colonic motor patterns were studied in vivo in a healthy volunteer using High-Resolution Colonic Manometry (HRCM) with an 84-sensor water perfused catheter with 1cm spacing. 5-HT and 5-HT4 receptor immunohistochemistry was performed on human tissue biopsies throughout the colon. Key results: Activating mucosal 5‐HT4 receptors via intraluminal prucalopride enhanced propulsive motor activity in the human colon by increasing occurrence and amplitude of propulsive motor patterns including high-amplitude propagating pressure waves (HAPWs), pancolonic simultaneous pressure waves (SPWs) and HAPW-SPWs. Prucalopride-induced motor patterns had a close temporal association with a significant degree of anal sphincter relaxation and some were accompanied by a strong urge to defecate. Biopsies showed 100% colocalization of the 5-HT4 receptor to enterochromaffin cells throughout the colon and rectum. Conclusions and inferences: Activating luminal 5‐HT4 receptors on enterochromaffin cells by intraluminal prucalopride increased propulsive motor activity. 5-HT4 receptors were found only on enterochromaffin cells and not ubiquitous on all epithelial cells. Our data support incorporation of prucalopride in colon‐specific drug delivery systems as a prokinetic to treat colonic hypomotility disorders. View ... Propulsive activity in the rabbit colon takes the form of the Colonic Motor Complexes (CMCs) (15, 24, 33,39,45). The development of the CMC occurs in a dose-dependent and antagonist sensitive manner, manifested in various levels of excitation beginning with clusters of fast propagating contractions followed by long distance contractions (LDCs) as the most forceful representation of the CMC in the rabbit. ... Intraluminal Prucalopride Increases Propulsive Motor Activities in the Human Colon Preprint Full-text available May 2020 Mitra Shokrollahi Xuan-Yu Wang Natalija Milkova Jihong Chen Background: Luminal application of 5-HT4 receptor agonists can increase peristalsis in the guinea pig, mouse, rat and rabbit colon. Our aim in the present study was to test the effects of intraluminal prucalopride on motor patterns in the human colon. Methods: Colonic motor patterns were studied in vivo in a healthy volunteer using High- Resolution Colonic Manometry (HRCM) with an 84-sensor water perfused catheter with 1cm spacing. 5-HT and 5-HT4 receptor immunohistochemistry was performed on human tissue biopsies throughout the colon. Key results: Activating mucosal 5-HT4 receptors via intraluminal prucalopride enhanced propulsive motor activity in the human colon by increasing occurrence and amplitude of propulsive motor patterns including high-amplitude propagating pressure waves (HAPWs), pan-colonic simultaneous pressure waves (SPWs) and HAPW-SPWs. Prucalopride-induced motor patterns had a close temporal association with a significant degree of anal sphincter relaxation and some were accompanied by a strong urge to defecate. Biopsies showed 100% colocalization of the 5-HT4 receptor to enterochromaffin cells throughout the colon and rectum. Conclusions and inferences: Activating luminal 5-HT4 receptors on enterochromaffin cells by intraluminal prucalopride increased propulsive motor activity. 5-HT4 receptors were found only on enterochromaffin cells and not ubiquitous on all epithelial cells. Our data support incorporation of prucalopride in colon‐specific drug delivery systems as a prokinetic to treat colonic hypomotility disorders. ... 39 Another prominent motor pattern in the rabbit colon is the propagating haustral boundary contraction that also has neurogenic and myogenic features. 31,39, 40 The haustral boundary contractions are segmental in nature due to their continuous interaction with ripples 31,39,41 which are rhythmic myogenic slowwave-driven contractions of low amplitude. 31 ... Intraluminal Prucalopride Increases Propulsive Motor Activities via Luminal 5-HT4 Receptors in the Rabbit Colon Article Apr 2019 Mitra Shokrollahi Jihong Chen
https://www.researchgate.net/publication/331090898_Noradrenaline_inhibits_neurogenic_propulsive_motor_patterns_but_not_neurogenic_segmenting_haustral_progression_in_the_rabbit_colon
Cultural revolution One of the world’s blandest regions has become one of its most creative | Special report Cultural revolution One of the world’s blandest regions has become one of its most creative TWENTY YEARS AGO the Nordic region was a cultural backwater. Even the biggest cities were dead after 8pm. The restaurants offered meatballs or pale versions of Italian or French favourites. The region did come up with a few cultural icons such as Ingmar Bergman and Abba, and managed to produce world-class architects and designers even at the height of post-war brutalism. But the few successes served only to emphasise the general dullness. The backwater has now turned into an entrepot. Stockholm relishes its reputation as one of the liveliest cities in Europe (and infuriates its neighbours by billing itself as “the capital of Scandinavia”). Scandinavian crime novels have become a genre in their own right. Danish television shows such as “The Killing” and “Borgen” are syndicated across the world. Swedish music producers are fixtures in Hollywood. Copenhagen’s Noma is one of the world’s most highly rated restaurants and has brought about a food renaissance across the region. Why has the land of the bland become a cultural powerhouse? Jonas Bonnier, CEO of the Bonnier Group, Sweden’s largest media company, thinks that it is partly because new technologies are levelling the playing field. Popular music was once dominated by British and American artists who were able to use all sorts of informal barriers to protect their position. Today, thanks to the internet, somebody sitting in a Stockholm attic can reach the world. Rovio’s Michael Hed suggests that network effects are much more powerful in small countries: as soon as one writer cracks the global detective market, dozens of others quickly follow. All true. But there is no point in giving people microphones if they have nothing to say. The bigger reason why the region’s writers and artists—and indeed chefs and game designers—are catching the world’s attention is that they are so full of vim. They are reinventing old forms such as the detective story or the evening meal but also coming up with entirely new forms such as video games for iPads. The cultural renaissance is thus part of the other changes that have taken place in the region. A closed society that was dominated by a single political orthodoxy (social democracy) and by a narrow definition of national identity (say, Swedishness or Finnishness) is being shaken up by powerful forces such as globalisation and immigration. All the Nordics are engaged in a huge debate about their identity in a post-social democratic world. Think-tanks such as Denmark’s Cepos flaunt pictures of Milton Friedman in the same way that student radicals once flaunted pictures of Che Guevara. Writers expose the dark underbelly of the old social democratic regime. Chefs will prepare anything under the sun as long as it is not meatballs. The region’s identity crisis is creating a multicultural explosion. The Nordics are scavenging the world for ideas. They continue to enjoy a love-hate relationship with America. They are discovering inspiration from their growing ethnic minorities but are also reaching back into their own cultural traditions. Swedish crime writers revel in the peculiarities of their culture. Danish chefs refuse to use foreign ingredients. A region that has often felt the need to apologise for its culture—those bloodthirsty Vikings! Those toe-curling Abba lyrics! Those naff fishermen’s jumpers!—is enjoying a surge of regional pride. Blood and snow Over the past decade Scandinavia has become the world’s leading producer of crime novels. The two Swedes who did more than anyone else to establish Nordic noir—Stieg Larsson and Henning Mankell—have both left the scene of crime. Larsson died of a heart attack in 2004 before his three books about a girl with a dragon tattoo became a global sensation. Mr Mankell consigned his hero, Kurt Wallander, to Alzheimer’s after a dozen bestsellers. But their books continue to be bought in their millions: “Dragon Tattoo” has sold more than 50m, and the Wallander books collectively even more. A group of new writers, such as Jo Nesbo in Norway and Camilla Lackberg in Sweden, are determined to keep the flame burning. And the crime wave is spreading beyond adult fiction and the written word. Sweden’s Martin Widmark writes detective stories for children. Swedish and British television producers compete to make the best version of Wallander. “The Killing” established a new standard for televised crime drama. The region has a long tradition of crime writing. Per Wahloo and Maj Sjowall, a Swedish husband-and-wife team, earned a dedicated following among aficionados with their police novels in the 1960s and 1970s. They also established two of Nordic noir’s most appealing memes. Martin Beck is an illness-prone depressive who gets to the truth by dint of relentless plodding. The ten Martin Beck novels present Sweden as a capitalist hellhole that can be saved only by embracing Soviet-style communism (the crime at the heart of the novels is the social democratic system’s betrayal of its promise). Today’s crime writers continue to profit from these conventions. Larsson’s Sweden, for example, is a crypto-fascist state run by a conspiracy of psychopathic businessmen and secret-service agents. But today’s Nordic crime writers have two advantages over their predecessors. The first is that their hitherto homogenous culture is becoming more variegated and their peaceful society has suffered inexplicable bouts of violence (such as the assassination in 1986 of Sweden’s prime minister, Olof Palme, and in 2003 of its foreign minister, Anna Lindh, and Anders Breivik’s murderous rampage in Norway in 2011). Nordic noir is in part an extended meditation on the tension between the old Scandinavia, with its low crime rate and monochrome culture, and the new one, with all its threats and possibilities. Mr Mankell is obsessed by the disruption of small-town life by global forces such as immigration and foreign criminal gangs. Each series of “The Killing” focuses as much on the fears—particularly of immigrant minorities—that the killing exposes as it does on the crime itself. The second advantage is something that Wahloo and Sjowall would have found repulsive: a huge industry complete with support systems and the promise of big prizes. Ms Lackberg began her career in an all-female crime-writing class. Mr Mankell wrote unremunerative novels and plays before turning to a life of crime. Thanks in part to Larsson, crime fiction is one of the region’s biggest exports: a brand that comes with a guarantee of quality and a distribution system that stretches from Stockholm to Hollywood. Copenhagen is the restaurant capital of Europe, largely thanks to Noma, which has been rated among the world’s best restaurants for the past three years, and to its founders, Claus Meyer and René Redzepi. Mr Redzepi, the head chef, eschews the standard fare of Mediterranean cooking such as olive oil and sun-dried tomatoes in favour of local products such as mushrooms, cloudberries, seaweed and flowers, which he collects from beaches and hedgerows. His signature dishes include vegetables in “soil” (a mixture of flour, melted butter and beer) and “the Hen and the Egg” (which customers are asked to cook for themselves, under supervision). Noma’s guests should “experience something that can only happen in this particular part of the world and in this particular city”, he says. But they need to be patient: the waiting list for bookings is three months. The thousands who are turned away from Noma still have plenty to choose from. Mr Meyer’s food empire includes a bakery chain, a catering business, a vinegar brewery, an organic orchard, a collection of public allotments and a “Nordic Food Lab” that operates from a boat berthed round the corner from Noma, all dedicated to his mission to rid Denmark of its “uniform, generic, passionless food”. Noma has dozens of imitators-cum-competitors, such as Geranium in Copenhagen, Malling & Schmidt in Aarhus and Ti Trin Ned in Fredericia. Local supermarkets sell local wild garlic. The beaches and hedgerows are thick with foodies scavenging for their dinner. Open-source culture The Bremen theatre used to be one of the mainstays of the pornography industry: mighty printing presses whirred day and night in order to slake the world’s thirst for pictures of copulating Danes. Today it is the home of Volcano, a “multifaceted entertainment company” that employs 22 people. Its boss, Kristian Riis, is trying to bring imaginative flair to the often routine business of running a nightclub-cum-concert hall. He mixes concerts with stand-up comedy and quiz nights and particularly prides himself on his ability to connect different worlds. He helps the foreign ministry feature Danish musicians in Danish embassies abroad. He arranges deals between companies who want to reach the young and bands that want to make money. These deals usually break down because companies lack nuance (they expect bands to wear their logos or T-shirts) and bands constantly worry about selling out. Volcano feels it can bring these two worlds together because “we’re not afraid of talking about money.” Much the biggest regional power in the music industry is Sweden. Its record producers and songwriters are a big force in the American record industry: about a third of the records in the Billboard 100 bestsellers have Swedish fingerprints on them. Sweden has also produced groups that have enjoyed international success in their own right, such as Swedish House Mafia, Robyn and, more recently, The Tallest Man on Earth. So far Finland has not extended its success in video games to other areas of the culture industry. Finnish detective novels are too depressing. Finnish music is too tortured. But do not mistake lack of global reach for lack of creativity: the country that produced Linux, an open-source computer operating system, is also proud to be able to organise “open-source” cultural happenings that allow anyone to have a go. The biggest annual national opera festival featured an open-source opera in 2012. Helsinki has an annual restaurant day when everybody is encouraged to serve up what they like. Parks fill with pop-up restaurants. Streets are converted into outdoor eateries. Restaurant day has inspired a succession of other “days” such as spring-cleaning day (when Helsinki becomes a giant flea market) and teaching day (when games players teach people how to design games and cobblers how to cobble). “These kinds of citizen-led events and innovations make Helsinki a really good city at the moment,” says Outi Kuittinen of Demos, a local think-tank. “It used to be a lot duller.”
https://www.economist.com/special-report/2013/01/31/cultural-revolution
(PDF) Enhanced dissolved organic carbon production in aquatic ecosystems in response to elevated atmospheric CO2 PDF | Although aquatic ecosystems are a major carbon reservoir, how their carbon dynamics will respond to increasing concentrations of atmospheric CO2... | Find, read and cite all the research you need on ResearchGate Article PDF Available Enhanced dissolved organic carbon production in aquatic ecosystems in response to elevated atmospheric CO2 April 2014 Biogeochemistry118(1-3) DOI: 10.1007/s10533-013-9904-7 Authors: <here is a image 26ac25ec4553b6ce-2362255dfe8752a1> Chao Song Lanzhou University <here is a image f2f62089ad6ff61c-d19572ff1996375a> Ford Ballantyne IV Ford Ballantyne IV This person is not on ResearchGate, or hasn't claimed this research yet. <here is a image c8904468c9f9f693-5ddcb1b9b9b9be58> Val H. Smith University of Kansas Abstract and Figures Although aquatic ecosystems are a major carbon reservoir, how their carbon dynamics will respond to increasing concentrations of atmospheric CO2 is not well understood. The availability of essential nutrients has the potential to modify carbon fluxes under elevated CO2 by altering carbon processing and storage in the biota. Here, we describe a semi-continuous culture experiment with natural phytoplankton and bacteria assemblages designed to investigate (1) how carbon dynamics in aquatic ecosystems respond to continuously elevated atmospheric CO2, and (2) whether carbon fluxes resulting from elevated CO2 are modified by changes in inorganic nitrogen and phosphorus availability. Our results showed that elevated CO2 led to significant increases in photosynthetic carbon uptake, despite a decrease in the algal chlorophyll a concentrations and no significant change in total algal biovolume. This enhancement of inorganic carbon uptake was accompanied by a significant increase in dissolved organic carbon (DOC) production. Concurrent increases in the C/N and C/P ratios of dissolved organic matter also suggested that DOC stability increased. Nutrient availability, especially nitrogen availability, had strong effects on inorganic carbon uptake and biomass carbon pools. In contrast, CO2-enhanced DOC production was not significantly affected by varying concentrations of inorganic nitrogen and phosphorus. Our study underscores the importance of DOC as a potential carbon sink in aquatic ecosystems. The observed responses to changes in CO2 and nutrient availability could have important implications for long-term carbon cycling in aquatic ecosystems, and highlight the potential buffering capacity of aquatic ecosystems to future environmental change. <here is a image 52640be1692b9c8d-54f48555259f50a5> Schematic diagram of carbon pools and carbon fluxes in the experimental systems … Figures - uploaded by Chao Song ... Freshwater systems have garnered less attention than marine systems in terms of elevated CO 2 effects, and the high heterogeneity in carbonate chemistry within and among freshwater systems complicates predictions of long-term responses to elevated atmospheric CO 2 (Cole et al. 2007; Song et al. 2014 ). Among freshwater systems, ambient pH can range from 3.8 to 9.9 and ambient DIC (CO 2 + HCO 3 − + CO 3 2− ) concentrations can vary from 0.005 to 146 mM (Cole et al. 1994). ... ... Nutrient levels (e.g., nitrogen and phosphorus) also vary within and among freshwater systems, and impacts of elevated CO 2 may be increased when nutrients are not limiting (Low-Decarie et al. 2014;Hasler et al. 2016). With such variations in freshwater DIC dynamics, it is not well understood or easily predictable how freshwater systems will respond to longterm increases in atmospheric CO 2 (Cole et al. 2007; Song et al. 2014) . ... Strong effects of elevated CO2 on freshwater microalgae and ecosystem chemistry Article Full-text available Aug 2019 LIMNOL OCEANOGR <here is a image 52758f80a23cab8d-335e34ed0d33669a> Terry-René Brown <here is a image d7a5cbbf04e8e7c6-0a6594b333e19c0d> Marc J. Lajeunesse Kathleen Scott The carbonate chemistry of freshwater systems can range from inorganic carbon‐limited to supersaturated with respect to the atmosphere, and the pH of these systems can vary temporally and spatially from alkaline to acidic. Determining how these heterogeneous systems respond to increases in atmospheric CO2 is critical to understanding global impacts of these changes. Here, we synthesize 22 studies from a variety of systems to explore the effects of elevated CO2 on freshwater chemistry and microalgae, which form the base of autotrophic food webs. Across the variability in freshwater systems, elevated CO2 significantly affected water chemistry by decreasing pH and increasing dissolved inorganic carbon. Microalgae were also affected by elevated CO2 with measured increases in (1) nutrient acquisition through microalgal carbon‐to‐nutrient ratios, (2) photosynthetic activity, and (3) growth. While these effects were measured from controlled experiments, the results indicate a wide range of potential freshwater ecosystem effects from elevated atmospheric CO2. Our synthesis also identified several knowledge gaps. Generally, larger sample sizes and studies of longer duration are needed for more robust analyses and conclusions. Additionally, more field experiments across a range of freshwater ecosystem types and studies involving benthic species and multiple trophic levels are needed to strengthen global predictions across the broad variability found within and among freshwater systems. ... In the tributaries of the Mississippi River DOC subsequently decreased with 58%, leading to a lower downstream DOC concentration in the river (Duan et al., 2017). A third cause that could lead to increased DOC concentration is the effects of climate change such as: (i) increased precipitation (Wu et al., 2007;Brothers et al., 2014), but in other cases also (ii) decreased precipitation (Porcal et al., 2009) in combination with (iii) increased temperature (Fenner and Freeman, 2011), (iv) rising CO 2 emissions, which can cause increased organic matter production by terrestrial (Zangerl and Bazzaz, 1984) and aquatic (Song et al., 2013) primary producers, and (v) increased nitrogen deposition (McElarney et al., 2010), although there are also studies that claim that DOC increases are caused by a decrease in nitrogen deposition (Musolff et al., 2017). ... ... If the quantity and quality of DOC are changed by climate change, this may have large effects on the extent of C sequestration in aquatic sediments and on aquatic CO 2 emissions. Although it is important to study the fate of DOC, DOC itself can also be regarded as C sink for anthropogenically emitted CO 2 as DOC production in algae increases under elevated CO 2 concentrations (Song et al., 2013) . ... The Future of Freshwater Macrophytes in a Changing World: Dissolved Organic Carbon Quantity and Quality and Its Interactions With Macrophytes May 2018 <here is a image 909998d85a2d9b6b-b9a978f18cdcc426> Rosanne E. Reitsema <here is a image a556cda72b671309-078d40d97bc9bd2a> Patrick Meire <here is a image 41a127784e6d89e5-a79722e85b93909e> Jonas Schoelynck Freshwater ecosystems are confronted with the effects of climate change. One of the major changes is an increased concentration of aquatic carbon. Macrophytes are important in the aquatic carbon cycle and play as primary producers a crucial role in carbon storage in aquatic systems. However, macrophytes are affected by increasing carbon concentrations. The focus of this review lies on dissolved organic carbon (DOC), one of the most abundant forms of carbon in aquatic ecosystems which has many effects on macrophytes. DOC concentrations are rising; the exact cause of this increase is not known, although it is hypothesized that climate change is one of the drivers. The quality of DOC is also changing; for example, in urban areas DOC composition is different from the composition in natural watersheds, resulting in DOC that is more resistant to photo-degradation. Plants can benefit from DOC as it attenuates UV-B radiation, it binds potentially harmful heavy metals and provides CO2 as it breaks down. Yet plant growth can also be impaired under high DOC concentrations, especially by humic substances (HS). HS turn the water brown and attenuate light, which limits macrophyte photosynthesis at greater depths. This leads to lower macrophyte abundance and lower species diversity. HS form a wide class of chemicals with many different functional groups and they therefore have the ability to interfere with many biochemical processes that occur in freshwater organisms. Few studies have looked into the direct effects of HS on macrophytes, but there is evidence that HS can interfere with photosynthesis by entering macrophyte cells and causing damage. DOC can also affect reactivity of heavy metals, water and sediment chemistry. This indirectly affects macrophytes too, so they are exposed to multiple stressors that may have contradictive effects. Finally, macrophytes can affect DOC quality and quantity as they produce DOC themselves and provide a substrate to heterotrophic bacteria that degrade DOC. Because macrophytes take a key position in the aquatic ecosystem, it is essential to understand to what extent DOC quantity and quality in surface water are changing and how this will affect macrophyte growth and species diversity in the future. ... Rhizosphere activities in response to elevated CO2 and phosphorous availability The effect of elevated CO2 on rhizosphere properties is likely to impact on the ability of plants to acquire P from the soil. Elevated CO2 is likely to increase C flow from plant to soil by increasing the release of root exudates (Lin et al., 2000; Song et al., 2014) . These exudates contain functional molecules that facilitate an increase in rhizosphere P solubility, and hence improve P nutrition to plants (Richardson et al., 2009;. ... Climatic changes and their effects on physiological and nutritional status of crop plants: importance and Strategies. A review Jul 2021 Abou Seeda <here is a image a2f1cd154e6b5733-6b1d64324145f388> El-Zanaty Abd El-Motaleb Aly Abou El-Nour Sahar M Zaghloul Climate change represents one of the greatest research challenges currently faced by plant biologists, agronomists and conservation biologists. Greenhouse gas emissions set to continue to rise for the near future. Impact of elevated atmospheric eCO2 and associated shifts in temperature and precipitation are all expected to impact plant ecophysiology, distribution and interactions with other organisms. Climate change such as drought, flood, high temperature, storm etc. are increased dramatically. Climate change has both direct and indirect impacts on agricultural production systems. Direct impacts include effects caused by a modification of physical characteristics e.g. temperature levels and rainfall distribution on specific agricultural production systems. Indirect impacts are those that affect production through changes on other species such as pollinators, pests, disease vectors and invasive species. These indirect effects can play a major role. They are much more difficult to assess and project given the high number of interacting parameters and links, many of which are still unknown. Climate change influences food security in a very complicated manner, it hampers the agricultural yield directly by means of disturbing the agro-ecological environment and indirectly by putting pressure on growth and circulation of income and consequently, increased the necessity of agricultural products. Impacts of climate change on food security have been calculated in several ways. Consequently, due to climate changes, many regions of cultivated land may become unsuitable for cultivation, and other tropical regions may produce more crops. Temperature instability will also provide more favorable environmental conditions for insect, pests of crops to boost their capacity to stay alive in cold temperatures and then emerge in outbreaks in spring. It is very crucial to observe that in case of food accessibility, all recent calculations for food security and safety have concentrated mainly on the effects of climate change in ways that did not measure the probability of substantial alteration in the rate of climate extremes on crop productivity. The atmospheric eCO2 levels have been progressing from the 280 ppm, preindustrial reference levels to current global levels exceed now above 400 ppm. Although the increasing concentration of atmospheric eCO2 is the main driver of harmful anthropogenic. Climate change, it can also improve crop performance by increasing rates of photosynthesis and water use efficiency (WUE), particularly in C3 plants. The putative positive effect in agriculture is in fact denoted to as the "CO2 fertilization effect" This effect has already been observed in crop plants and vegetables. However, longer treatments with eCO2 might lead to photosynthetic acclimation, due to increased soluble sugars leading to an imbalanced C: N ratio, accelerated leaf senescence and/or limited growth rate. ... Aquatic macrophytes play a crucial role in carbon storage in aquatic systems. However, aquatic macrophytes are affected by increasing carbon concentrations which are related to rising CO2 emissions, which increase organic matter production by aquatic primary producers [17] . ... Ecosystem Organic Carbon Stock Estimations in the Sile River, North Eastern Italy <here is a image 0cfcaa3f83397c98-c438649e3fe3cf85> Alessandro Buosi <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Yari Tomio <here is a image 71dc02af1ea9d85b-b46e84aa08e59413> abdul-salam Juhmani <here is a image 8986132969cb2e6c-e6a077b829c0c2f6> Adriano Sfriso River ecosystems are one of the dynamic components of the terrestrial carbon cycle that provide a crucial function in ecosystem processes and high value to ecosystem services. A large amount of carbon is transported from terrestrial to the ocean through river flows. In order to evaluate the contribution of Sile River ecosystem to the global carbon stock, the river ecosystem Organic Carbon (OC) stock was quantified for sediments and dominant submerged aquatic macrophytes (SAMs) during the two sampling periods at three different stations along the Sile River (North Eastern Italy). The total mean ecosystem OC stock was 95.2 ± 13.8 Mg C ha −1 while those of SAMs ranged from 7.0 to 10.9 Mg C ha −1 which accounted for approx. 10% of the total OC stock. The total aboveground biomass retains approx. 90% of the SAM carbon stock, with a mean of 8.9 ± 1.6 Mg C ha−1. The mean sediment OC stock was 86.6 ± 14.5 Mg C ha −1 with low seasonal variations among the sites. Indeed, various environmental parameters and hydrodynamics appear to affect the accumulation of OC within the river ecosystem. The results highlight the role that freshwater river ecosystems play in the global carbon cycle, which consequently provide a baseline for future river ecosystem monitoring programs. Furthermore, future studies with additional sites and seasonal surveys of the river will enhance our understanding of the effects of global climate change on the river ecosystem and improve the ecosystem services. ... Changes in intracellular metabolites of phytoplankton were also shown to affect higher trophic level organisms that are feeding on them (Rossoll et al., 2012;Cripps et al., 2016). Elevated CO 2 has also been found to promote extracellular organic carbon release in phytoplankton (Torstensson et al., 2013; Song et al., 2014) , changing the dynamics of the biological carbon pump and the remineralization of organic carbon. ... A metabolomic approach to investigate effects of ocean acidification on a polar microalga Chlorella sp Article AQUAT TOXICOL <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Yong Hao Tan <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Phaik Eem Lim <here is a image 3b2699a730ca7e00-edf911ab71c4d3f5> John Beardall <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Siew-Moi Phang ... This supports a previous work illustrating increased available phosphorus in soil, with various crops, including cotton, okra, and mungbean (Prasanna et al. 2014(Prasanna et al. , 2015Manjunath et al. 2016). Increase in CO 2 concentration may have increased the release of root exudates, which enhanced the flow of carbon between soil and plant (Lin et al. 2000; Song et al. 2014) . Root exudates influence rhizospheric activity, thereby modulating P availability and P acquisition by plants (Norby et al. 2001;deGraaff et al. 2006;Shen et al. 2011). ... Interplay of phosphorus doses, cyanobacterial inoculation, and elevated carbon dioxide on yield and phosphorus dynamics in cowpea Article Full-text available ENVIRON MONIT ASSESS <here is a image 0fd5062569988a04-5a60da3c8d868ad9> Sumit Kumar Dey Bidisha Chakrabarti <here is a image 4dee63d0fef5304a-46c2daf8b9f8e074> Tapan Purakayastha <here is a image 1b09587f5860686c-fd630674cb503203> Himanshu Pathak Phosphorus (P) demand is likely to increase especially in legumes to harness greater benefits of nitrogen fixation under elevated CO2 condition. In the following study, seed yield and seed P uptake in cowpea increased by 26.8% and 20.9%, respectively, under elevated CO2 level. With an increase in phosphorus dose up to 12 mg kg⁻¹, seed yield enhanced from 2.6 to 5.4 g plant⁻¹. P application and cyanobacterial inoculation increased the microbial activity of soil, leading to increased availability of P. Under elevated CO2 condition, microbial activity, measured as dehydrogenase, acid phosphatase, and alkaline phosphatase activities showed stimulation. Soil available P also increased under elevated CO2 condition and was stimulated by both P application and cyanobacterial inoculation. Higher P uptake in elevated CO2 condition led to lower values of inorganic P in soil. Stepwise regression analysis showed that aboveground P uptake, soil available P, and alkaline phosphatase activity of soil influenced the yield while available P, and organic and inorganic P influenced the aboveground P uptake of the crop. This study revealed that under elevated CO2 condition, P application and cyanobacterial inoculation facilitated P uptake and yield, mediated through enhanced availability of nutrients, in cowpea crop. Role of Phosphorus in Imparting Abiotic Stress Tolerance to Plants Chapter <here is a image 30a66cb4564068b1-8e8b944260e93804> Bhaswatee Baroowa <here is a image 76b79f82047157cd-71183dc6a3e5d07a> Sreyashi Paul <here is a image 82fa9e8338c9f667-a87f623981dc423e> Nirmali Gogoi Phosphorus (P) is one of the most abundant macronutrients in plant tissues and is indispensable for several key plant functions, including energy transfer, photosynthesis, transformation of sugars and starches, nutrient movement within the plant, and transfer of genetic characteristics from one generation to the next. Abiotic stresses such as low and high temperatures, osmotic shock and drought, excess soil moisture, elevated carbon dioxide (CO 2 ) lower the rate of nutrient transport from the root to the shoot by reducing transpiration rates and altering the cell transporter functions. This in turn hampers the growth, development, and yield processes leading to a decline in global crop productivity by more than 50% every year. Tolerance against these adverse environmental conditions is a complex phenomenon involving an array of mechanisms that will be critical in evaluating the impact of climate change and climate variability on crop production. Also, assessing the role of externally applied P in tolerating these unfavourable conditions will give an insight towards management practices against these stresses. In the present chapter, an overview of the influences of these abiotic stresses on various plant processes is provided. The chapter also covers the mitigation options to improve stress tolerance of crops especially through the external application of P that may become a promising strategy for minimizing the impact of climate change in near future. Differential responses of dominant and rare epiphytic bacteria from a submerged macrophyte to elevated CO2 ENVIRON SCI POLLUT R <here is a image 9994d93177b006f9-0587dd14e00277b7> Yang Li Lei Yang <here is a image fa7c1219ae993a10-6d2fb764d9c16cc4> Fei Ma <here is a image 5a9e7ed5289f04b2-8ce75f96507967a4> Dan Yu Epiphytic bacteria develop complex interactions with their host macrophytes and play an important role in the ecological processes in freshwater habitats. However, how dominant and rare taxa respond to elevated atmospheric CO2 remains unclear. A manipulated experiment was carried out to explore the effects of elevated CO2 on the diversity or functional characteristics of leaf epiphytic dominant and rare bacteria from a submerged macrophyte. Three levels (high, medium, normal) of dissolved inorganic carbon (DIC) were applied to the overlying water. The physicochemical properties of the overlying water were measured. Elevated atmospheric CO2 significantly decreased the pH and dissolved oxygen (DO) of overlying water. Proteobacteria, Cyanobacteria, Bacteroidetes, Planctomycetes, and Actinobacteria are the dominant phyla of leaf epiphytic bacteria from Myriophyllum spicatum, occupying over 90% of the accumulated relative abundances. The aquatic DIC level and further pH significantly drove the epiphytic community composition differences among the three DIC levels. For dominant epiphytic bacteria, the functional potential of nutrient processes and mutualistic relationships were strongly affected by a high DIC level, while responses of rare epiphytic bacteria were more related to trace element processes, pathogens, and defense strategies under a high DIC level. Our results showed the responses of epiphytic bacteria to elevated CO2 varied across dominant and rare taxa. Short-term effects of winter warming and acidification on phytoplankton growth and mortality: more losers than winners in a temperate coastal lagoon HYDROBIOLOGIA <here is a image ce83614a61cb68ec-3f802ac1455a1530> Rita B Domingues <here is a image 07cc3a392a5a2853-879164f20e6256a1> Marcelle Barreto <here is a image 8b41c4d80a5eb932-d8a520607e4dc865> Vanda Brotas <here is a image 77b3a51d9d1619b1-4c55f6d23e1ed5c3> Ana Branco Barbosa Changes in temperature and CO2 are typically associated with climate change, but they also act on shorter time scales, leading to alterations in phytoplankton physiology and community structure. Interactions among stressors may cause synergistic or antagonistic effects on phytoplankton dynamics. Therefore, the main goal of this work is to understand the short-term isolated and interactive effects of warming and high CO2 on phytoplankton nutrient consumption, growth, production, and community structure in the Ria Formosa coastal lagoon (southern Portugal). We performed microcosm experiments with temperature and CO2 manipulation, and dilution experiments under temperature increase, using winter phytoplankton assemblages. Phytoplankton responses were evaluated using inverted and epifluorescence microscopy. Overall, phytoplankton growth and microzooplankton grazing on phytoplankton decreased with warming. Negative antagonist interactions with CO2 alleviated the negative effect of temperature on phytoplankton and cryptophytes. In contrast, higher temperature benefited smaller-sized phytoplankton, namely cyanobacteria and eukaryotic picophytoplankton. Diatom growth was not affected by temperature, probably due to nutrient limitation, but high CO2 had a positive effect on diatoms, alleviating the effect of nutrient limitation. Results suggest that this winter phytoplankton assemblage is well acclimated to ambient conditions, and short-term increases in temperature are detrimental, but can be alleviated by high CO2. Responses of the large centric diatom Coscinodiscus sp. to interactions between warming, elevated CO 2 , and nitrate availability: Diatom responses to climate changes LIMNOL OCEANOGR Pingping Qu <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Fei-Xue Fu <here is a image c23e04f7c598b97b-0e158d5ed27fa076> D. A. Hutchins Marine ecosystems are facing multiple anthropogenic global changes, including ocean acidification, warming, and reduced nutrient supplies. Together, these will challenge phytoplankton including large centric diatoms such as Coscinodiscus sp., a group that is important to ocean food webs and carbon export. We investigated the interactive effects of warming, elevated CO2, and nitrate availability on Coscinodiscus growth, elemental stoichiometry, and Fe and C uptake rates in a four-treatment factorial experiment combining two CO2 levels (∼400 ppm and 800 ppm) and two temperatures (16°C and 20°C) across seven nitrate concentrations (1–100 μmol L−1). Higher temperatures led to higher maximum growth rates (μmax), but also higher half-saturation constants for nitrate (K1/2), while elevated CO2 increased K1/2 only at the warmer temperature. Lower μmax/K1/2 ratios under warming and rising CO2 indicated a higher nitrate requirement at these conditions. High temperature decreased cellular P and Si contents and consequently increased N : P and C : Si ratios, especially at ambient CO2. Fe : C uptake ratios responded positively to lower nitrate levels, lower CO2, and warming. Significant interactions between nitrate availability and temperature or CO2 were observed for specific growth rates, chlorophyll a and Si contents, Fe : C, N : P, and Si : C, while temperature and CO2 interactions were only significant for μmax/K1/2 and cellular P content. The mutual interactions among CO2 concentrations, temperature, and nitrate supply may all affect future growth, physiology, and carbon export by Coscinodiscus sp., however, in general warming and nitrate availability appear to be more influential than CO2. Carbon to volume relationship for dinoflagellates, diatoms and other protist plankton
https://www.researchgate.net/publication/260835850_Enhanced_dissolved_organic_carbon_production_in_aquatic_ecosystems_in_response_to_elevated_atmospheric_CO2
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(PDF) Biomineralisation of 1,2,4-trichlorobenzene in soils by an adapted microbial population PDF | In laboratory experiments the mineralisation of 14C-labelled 1,2,4-trichlorobenzene (1,2,4-TCB) in soils was studied by direct measurement of the... | Find, read and cite all the research you need on ResearchGate Biomineralisation of 1,2,4-trichlorobenzene in soils by an adapted microbial population February 2004 Environmental Pollution127(3):395-401 DOI: 10.1016/j.envpol.2003.08.012 Authors: <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Reiner Schroll Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) <here is a image 2a46b775da3de6e3-6c393ba537a7a119> Ferdi Brahushi Agricultural University of Tirana <here is a image f2f62089ad6ff61c-d19572ff1996375a> U Dörfler U Dörfler <here is a image f2f62089ad6ff61c-d19572ff1996375a> S Kühn S Kühn Abstract In laboratory experiments the mineralisation of 14C-labelled 1,2,4-trichlorobenzene (1,2,4-TCB) in soils was studied by direct measurement of the evolved 14CO2. The degradation capacity of the indigenous microbial population was investigated in an agricultural soil and in a soil from a contaminated site. Very low mineralisation of 1% within 23 days was measured in the agricultural soil. Whereas in the soil from the contaminated site the mineralisation occurred very fast and in high rates; up to 62% of the initially applied amount of 1,2,4-TCB were mineralised within 23 days. The transfer of the adapted microbial population into the agricultural soil significantly enhanced the mineralisation of 1,2,4-TCB in this soil, reflecting, that the transferred microbial population survived and maintained its degradation ability in the new microbial ecosystem. Additional nutrition sources ((NH4)2HPO4) increased the mineralisation rates in the first days significantly in the contaminated soil. In the soil from the contaminated site high amounts of non extractable 14C-residues were formed. Content uploaded by Ferdi Brahushi Biomineralisation of 1,2,4-trichlorobenzene in soils by an adapted microbial population R. Schroll a , F. Brahushi a ,U.Do ¨ rfler a, * ,S.Ku ¨ hn a , J. Fekete b , J.C. Munch a a GSF—National Research Center for Environment and Health, Institute of Soil Ecology, D-85764 Neuherberg, Germany b Budapest University of Technology and Economics, Institute of General and Analytical Chemistry, H-111 Budapest, Hungary Received 30 April 2003; accepted 1 August 2003 ‘‘Capsule’’: Enhanced mineralisation of 1,2,4-trichlorobenzene was observed in an agricultural soil by inoculating it with an adapted microbial community. Abstract In laboratory experiments the mineralisation of 14 C-labelled 1,2,4-trichlorobenzene(1,2,4-TCB) in soils was studied by direct measure- ment of the evolved 14 CO 2 . The degradation capacity of the indigenous microbial population was investigated in an agricultural soil and in a soil from a contaminated site. Very low mineralisation of 1% within 23 dayswas measured in the agricultural soil. Whereas in the soil from the contaminated site the mineralisation occurred very fast and in high rates; up to62% of the initially applied amount of 1,2,4-TCB were mineralised within 23 days. The transfer of the adapted microbial population into the agricultural soil significantly enhanced the miner- alisation of 1,2,4-TCBin this soil, reflecting, that thetransferred microbial population survived and maintained itsdegradationability in the new microbial ecosystem. Additional nutrition sources ((NH 4 ) 2 HPO 4 ) increased the mineralisation rates in the first days significantly in the contaminated soil. In the soil from the contaminated site high amounts of non extractable 14 C-residues were formed. # 2003 Elsevier Ltd. All rights reserved. Keywords: 1,2,4-Trichlorobenzene; Soil; Mineralisation; Adapted microorganisms; Non extractable residues 1. Introduction 1,2,4-Trichlorobenzene (1,2,4-TCB) is one of the most widely used chlorobenzenes. Due to its use as a dye carrier, pesticide intermediate, heat-transfer medium, dielectric fluid in transformers, degreaser, lubricant and solvent in chemical manufacturing it has become a ubi- quitous environmental pollutant. High chlorinatedbenzenes can only be degraded by preliminary reductive dechlorination ( Beurskens et al., 1993; Ramanand et al., 1993; Nowak et al., 1996; Prytula and Pavlostathis, 1996; Chang et el., 1998; Yuan et al., 1999; Pavlostathis and Prytula, 2000; Wu et al., 2002 ), whereas lower chlorinated benzenes can be mineralised under aerobic conditions. Aerobic mineralisation of mono-, di-, tri- and even tetrachlorobenzenes is reported ( Marinucci and Bartha, 1979, Nishino et al., 1992, Brunsbach and Reineke, 1995, Yadav et al., 1995, Rapp and Timmis,1999, Tchelet et al., 1999, Brahushi et al., 2002, Dermietzel and Vieth, 2002 ). Furthermore, several pure strains were isolated and described which used chlorobenzenes as the sole source of carbon and energy ( de Bont et al., 1986; Schraa et al., 1986; van der Meer et al., 1987; Spain and Nishino, 1987; Haigler et al., 1988; Sander et al., 1991; Potrawfke et al., 1998 ). Many biodegradation and mineralisation studies of 1,2,4-TCB in pure cultures and environmental samples have been performed. The results from these laboratory experiments are diverse. In aquifer samples no sig- nificant mineralisation was found for 1,2,4-TCB after eight months of incubation ( Aelion et al., 1987 ). Under aerobic conditions 1,2,4-TCB was only degraded in low amounts in the presence of nutrients (KH 2 PO 4 , K 2 HPO 4 ,Na 2 HPO 4 , (NH 4 ) 2 SO 4 , MgSO 4 , FeSO 4 )by the indigenous microorganisms originated from a con- taminated aquifer ( Dermietzel and Vieth, 2002 ). Very low mineralisation rates of 1,2,4-TCB were also repor- ted in soil ( Scheunert and Korte, 1986, Marinucci and Bartha, 1979 ); mineral fertilisers or cosubstrates failed to increase the mineralisation rates ( Marinucci and Bartha, 1979 ). Moreover, in soil slurry ( Brunsbach and 0269-7491/$ - see front matter # 2003 Elsevier Ltd. All rights reserved. doi:10.1016/j.envpol.2003.08.012 Environmental Pollution 127 (2004) 395–401 www.elsevier.com/locate/envpol *Corresponding author. Fax: +49-89-3187-3376. E-mail address: doerfl[email protected] (U. Do ¨ rfler). Reineke, 1994 ) and activated sludge ( Freitag et al., 1985 ) 1,2,4-TCB was not degraded, but after inocul- ation of the soil slurry with a Pseudomonas aeruginosa strain, which is a known mono- and 1,4-dichloro- benzene-degrading organism, 1,2,4-TCB was co-meta- bolized, but the degradation was incomplete and stopped when mono- and 1,4-dichlorobenzene were totally con- sumed ( Brunsbach and Reineke, 1994 ). The native microbial population of sandy sediments from the river Rhine was not able to degrade 1,2,4-TCB; inoculation of the percolation columns with Pseudomonas sp. strain P51 however resulted in rapid degradation,as was measured by disappearance of 1,2,4-TCB ( van der Meer et al., 1987 ). Tchelet et al. (1999) investigated the survival of Pseudomonas sp. strain P51 after its release into two experimental systems. When strain P51 was released into microcosms of water saturated sandy river sedi- ments it remained active and was able to degrade 1,2,4-TCB since profile measurements along the length of the column showed a clear decrease in 1,2,4-TCB concentration; but when Pseudomonas sp. strain P51 was released into sludge microcosms it did not survive. In a BBA standard soil inoculated with Burkholderiasp. strain PS14 the initially applied 1,2,4-TCB concen- tration of 54.4 ppb fell below the detection limit of 0.09 ppb within an incubation time of 72 h and mineralisa- tion amounted to 80% as was recorded by indirect measurement of CO 2 ( Rapp and Timmis, 1999 ). Sander et al. (1991) elucidated the metabolic pathway for 1,2,4-TCB degradation by Pseudomonas sp. PS12 which was isolated from soil samples of an industrial waste deposit. This microbial species degrades 1,2,4-TCB via a chlorinated dihydrodiol (3,4,6-trichloro-1,2-dihydroxy- cyclohexa-3,5-diene), a chloro-substituted catecol (3,4,6-Trichlorocatecol) and a chlorinated muconic acid (2,3,5-trichloro- cis , cis -muconic acid) to the central metabolic intermediates succinate (2,5-dichloro-4-car- boxy-methylenebut-2-en-4-olide) and (chloro)acetate (2,5-dichloromaleylacetic acid). The reported data show that biodegradation of 1,2,4-TCB in natural samples occur in very low rates due to insufficient degradation capacity and slow adap- tation of the indigenous microorganisms. By inocul- ation with specialised bacteria the biodegradation of 1,2,4-TCB could be enhanced. But the release of these strains may be related with difficulties because they often are not able to maintain their activity in natural ecosystems and even do not survive. Moreover the reported data are often based on the disappearance of the parent compound and processes like volatilisation and formation of bound residues which are also involved in the fate of a xenobiotic in soil environments are not considered. The main objective of our study was to find an applic- able method to enhance the in situ biodegradation of 1,2,4-TCB in soils by inoculating them with a microbial community with known degradation ability. Since an overall evaluation of the fate and behaviour of a xeno- biotic in soils is only possible when all relevant pro- cesses are considered, we conducted our experiments with 14 C-1,2,4-TCB and measured not only mineralisa- tion directly but also volatilisation and formation of nonextractable residues. The use of the 14 C-technique enabled the establishment of a 14 C mass balance. The experiments were performed in a special closed laboratory system which allowed a clear separation between miner- alisation and volatilisation processes aswell asthe deter- mination of soil respiration as a microbial activity parameter. Mineralisation of 14 C-1,2,4-TCB was first studied in soils from anagricultural and acontaminated site to evaluate the degradation capacity of the indigenous microorganisms. In afurther approach, it was investigated whether the mineralisation potential in the agricultural soil could be enhanced by inoculation with the adapted microbial community ofthe soil from a contaminated site. 2. Materials and methods 2.1. Chemicals Uniformly 14 C-ring-labelled 1,2,4-trichlorobenzene (purity > 98%, specific radioactivity 185 MBq/mMol) was obtained from International Isotope (Munich, Germany). Non labelled 1,2,4-trichlorobenzene was purchased from Dr. Ehrenstorfer (purity > 99.5%, Augsburg, Germany). The solvents were of analytical grade and were purchased from Merck (Darmstadt, Germany). The scintillation cocktails were obtained from Packard (Dreieich, Germany). 2.2.Soil materials For the model mineralisation experiments two differ- ent soil samples were used: an agricultural soil (AS) and a nonagricultural soil from a 1,2,4-TCB contaminated site (CS). In this soil the concentration of 1,2,4-tri- chlorobenzene amounted to 5.36 m g/g soil. Soils were sampled from the upper 20cm, sieved ( < 2 mm) and stored at 4  C for 1 month. Prior to starting the laboratory experiments, the soil samples were equilibrated for one week at 20  1  C and 50% of the water holding capacity (WHC). Some of the soil samples were homogeneously mixed with fertiliser and inoculum before they were equi- librated. Some soil properties are listed in Table 1 . 2.3.Spiking of soil samples 14 C-1,2,4-TCB, mixed with unlabelled 1,2,4-TCB was dissolved in n -hexane and applied to an aliquot of 3.5 g dried and pulverised soil sample in a 50 ml beaker glass. After evaporation of n-hexane the soil aliquot was 396 R.Schroll etal. / EnvironmentalPollution127 (2004)395–401 carefully stirred with a spatula and then transferred to a 200 ml beaker glass where it was mixed with 46.5 g(dry weight equivalent) of equilibrated soil. The spiked soil sample was transferred to the incubation flask, adjusted to 60% of WHC and connected to the closed laboratory system ( Fig. 1 ). The 14 C-losses during application amounted to 19.5 ( 1.8)%, as measured in preliminary experiments. Regarding these losses, the initial amount of 14 C-1,2,4-TCB in each soil sample was 5 (  0.1) mg/g soil (dry weight), corresponding to 23.5 (  0.47) kBq. 2.4.Mineralisation experiments The mineralisation of 14 C-1,2,4-TCB to 14 CO 2 was studied in a closed aerated laboratory system, as descri- bed previously ( Brahushi et al., 2002 ). The soil samples were incubated at 20  1  C for 23 days in the dark. At the sampling times the system was aerated for 1h with humidified CO 2 free air (1.0 l h  1 ) and the 14 C-volatile substances, the evolved 14 CO 2 from mineralisation of 14 C-1,2,4-TCB and CO 2 from soil respiration were absorbed in special traps. First sampling of the liquids in the traps was three days after application and then three times per week. For details see Brahushi et al. (2002) . Since 1,2,4-TCB is a volatile compound it was important, to use a laboratory system which allowed a strict separation between volatilised and mineralised radioactivity, otherwise the process of mineralisation would be overestimated ( Brahushi et al., 2002 ). Trapped CO 2 from microbial respiration was determined according to the method of Isermeyer (1952) . Biomi- neralisation of 14 C-1,2,4-trichlorobenzene was investi- gated in the agricultural soil (AS) and in the soil from the contaminated site (CS). Since soil CS was a non agricultural soil it was amended with a fertilizer ((NH 4 ) 2 HPO 4 , 2 mg/g soil). In another approach agri- cultural soil material was supplied with 5% of CS (dry weight), to investigate, whether the addition of soil material that contains 1,2,4-TCB adapted microorgan- isms could enhance the mineralisation of 1,2,4-TCB ina soil, where the indigenous microbial population was not exposed to a chlorobenzene contamination. The experi- ments were conducted in three replicates. 2.5.Soil residues At the end of the mineralisation experiments the soil samples were extracted. Three extraction methods (accelerated solvent extraction (ASE), soxhlet extrac- tion, and column extraction) were tested for their extraction efficiency of 1,2,4-trichlorobenzene from soil. For these tests, the 14 C-1,2,4-trichlorobenzene standard was applied prior to the extraction procedure directly to the soil in the ASE cell, the soxhlet thimble, or the glass column. Accelerated solvent extraction was performed in an ASE-200 (Dionex, Idstein, Germany) at a tem- perature of 90  C and a pressure of 10 MPa. Soxhlet extraction was conducted in a soxhlet apparatus for 8 h at 60  C, the cooler was kept at a temperature of  10 C to minimise the losses during the extraction process and column extraction was carried out in a glass column (50  2.5 cm). A mixture of hexane/acetone (3:1 v/v) was used as extraction solvent in each extraction method. The extraction efficiency experiments were conducted in Table 1 Physical and chemical properties of the soil samples (AS=soil from an agricultural site, CS=soil from a contaminated site, top soil 0 – 20 cm) Soil AS CS Clay (%)2424 Silt (%)6065 Sand (%)1611 pH (CaCl 2 )7.1 7.2 Corg. (%)1.681.96 N total (%)0.180.14 P 2 O 5 (mg/100 g soil)221.8 C/N ratio9.3/114/1 Fig. 1.Closed laboratory system: 1=humidifier (distilled water),2=incubation flask with soil sample, 3=cryostate (20  C), 4=cryostate (  10 C), 5=traps (cooled) for volatile organic substances (10 ml ethyleneglycolmonomethylether), 6=traps for CO 2 (15 ml 0.1N NaOH), 7=gas flow meter, 8=Woulfe‘s bottle, 9=charcoal filter, 10=pump. R.Schroll etal. / EnvironmentalPollution127 (2004)395–401 397 three replicates. For determination of radioactivity in liquid samples, aliquots of the sample were mixed witha scintillation cocktail (Ultima Gold XR) and measured in a liquid scintillation counter (Tricarb 1900 TR, Packard, Dreieich, Germany). The extraction recoveries of 14 C-1,2,4-TCB from soil for the tested extraction methods were 88.0 3.3%, 92.9  14.5% and 86.8  7.6% for accelerated solvent extraction, soxhlet extraction and column extraction, respectively. Since there were no significant differences between the extraction efficiencies of the three tested methods, we used ASE for the extraction of 1,2,4-TCB from the soil samples, which consumes less time and solvents than the other extraction techniques. The residual radioactivity in the soil after extraction (non extractable residues) was determined by combust- ing aliquots of the soil samples (Oxidizer 306, Packard, Dreieich, Germany), trapping the evolved 14 CO 2 in Carbo-Sorb E (Packard, Dreieich, Germany) and mix- ing it with Permafluor E (Packard, Dreieich, Germany) prior to liquid scintillation counting. The sum of 14 C-volatile compounds, 14 CO 2 , extrac- table and non extractable 14 C-residues, allowed the establishment of a 14 C mass balance. 3. Results 3.1.Mineralisation of 14 C-1,2,4-TCB Mineralisation of 1,2,4-TCB was followed for a per- iod of 23 days after application ( Fig. 2 ). High rates of mineralisation were observed in soil CS. Within the first 3 daysofincubation about 44% of 1,2,4-TCB was con- verted to CO 2 in soil CS with additional NP fertiliser, whereas in the same soilwithout NP fertiliser only 15% were mineralised. But after 23 daysof incubation no sig- nificant differences could be observed between the two treatments: 62 and 61% of applied 14 C-1,2,4-TCB were recovered as 14 CO 2 from soil CS without NP and from soil CS with NP, respectively. Incontrast, very low miner- alisation of 1% wasmeasuredin soil AS after the incu- bation time of 23 days. Addition of 5% soil CS to soil AS however strongly enhanced the mineralisation rate, result- ing in 51% mineralisation of 1,2,4-TCB within 23 days. In all treatments the mineralisation of 1,2,4-TCB started without a lag phase. In soil CS with NP-addition and without NP-addition the time courses of 14 CO 2 production were different. NP addition led to high mineralisation rates in the first days of incubation and the mineralisation curve reached a plateau after the first week of incubation. Without NP addition mineralisa- tion occurred in lower rates in the first days and the plateau phase was reached later. Mineralisation of 1,2,4-TCB in soil AS inoculated with soil CS showed a similar time course as in soil CS+NP which waschar- acterised by high rates of mineralisation during the first week of incubation, and decreasing rates with increasing incubation time. In soil AS without inoculum the mineralisation rates increased continuously, but in very much lower rates than in the other treatments. 3.2.Soil respiration To evaluate the microbial activity in the investigated soils the total evolution of CO 2 was determined during Fig. 2.Mineralisation of 14 C-1,2,4-trichlorobenzene in soils from a contaminated site (CS) and an agricultural site (AS) during 23 days ( n =3,  S.D.). Soil CS was amended with fertiliser (CS+NP) and soil AS was inoculated with 5% of soil CS (AS+inoc. CS). 398 R.Schroll etal. / EnvironmentalPollution127 (2004)395–401 the whole incubation time. Generally, soil respiration rates decreased with time in all treatments ( Fig. 3 ). In soil CS the addition of NP led to a striking increase of the microbial activity. Inoculating the soil AS with soil CS had no effect on the soil respiration. 3.3.Soil residues The extractable and non extractable 14 C-residues in the incubated soil samples varied considerably between the soils CS and AS ( Table 2 ). In soil AS without inoculum the extractable residues were between 64 and 74% and the non extractable residues were in the range of 3–4% of the applied radioactivity. Whereasin soil CS the extractable residues were very much lower (9%) with corresponding higher non extractable residues (25%). A similar distribution was observed in soil AS inoculated with soil CS: 15% extractable residues and 25% non extractable residues. The total recoveries of 14 C-radioactivity after the end of the experiments ran- ged from 75 to 100% of the applied radioactivity ( Table 2). 4. Discussion The very low rates of mineralisation observed in soil AS indicate that the native microbial population was not adapted to 1,2,4-TCB. The observed low miner- alisation in soil AS is in agreement with the results of former biodegradation studies of 1,2,4-TCB which were performed in arable soil ( Scheunert and Korte, 1986, Marinucci and Bartha, 1979 ), soil slurry (Brunsbach and Reineke, 1994 ) and aquifer solid samples ( Aelion et al., 1987 ). The occurrence of mineralisation in very low rates could be an indicator that the native microbial population of the agricultural soil had a potential ability for 1,2,4-TCB mineralisation but since the applied 14 C-1,2,4-TCB was not 100% pure, the measured 14 CO 2 production could also be due to the mineralisation of radiochemical impurities. In contrast, the mineralisation of 1,2,4-TCB in soil CS occurred in high rates up to 62%, because the indigen- ous microbial population of this soil was adapted to 1,2,4-TCB for 25 years and was therefore able to mineralise the contaminant in high amounts. Thus, the Fig. 3.The rates of total CO 2 production from soils from a contaminated site (CS) and an agricultural site (AS) during 23 days ( n =3,  S.D.). Soil CS was amended with fertiliser (CS+NP) and soil AS was inoculated with 5% of soil CS (AS+inoc. CS). Table 2 Distribution and mass balance of 14 C-1,2,4-TCB in the incubated soil samples (CS=soil from a contaminated site; AS=soil from an agricultural site; CS+NP=soil CS with fertiliser; AS+inoculum CS=soil AS, inoculated with 5% of soil CS) after 23 days of incubation (in % of applied radioactivity, n =3, S.D.) Treatments 14 CO 2 14 C-volatile substances 14 C-extractable 14 C-non extractable 14 C-recovery Soil CS60.5  4.8 5.0  3.2 9.0  0.7 25.0  1.0 99.5 6.8 Soil CS+NP62.3  3.9 1.0  0.2 8.6  1.3 23.9  1.3 95.8 6.0 Soil AS1.0  0.1 5.6  0.3 64.1  5.9 4.2  0.4 74.9 6.1 Soil AS+inoculum CS50.9  2.2 2.8  4.1 14.7  1.0 17.9  0.3 86.3 4.3 R.Schroll etal. / EnvironmentalPollution127 (2004)395–401 399 degradation ability of microorganisms appears to be closely dependent on their long-term adaptation to contaminated habitats as has been previously supposed by van der Meer et al. (1998) . The transfer of the adap- ted microbial community from soil CS into the agri- cultural soil significantly enhanced the mineralisation of 1,2,4-TCB in soil AS, reflecting, that the degrading capability of the transferred microbial population was conserved and that it was able to perform its degrada- tion potential in soil AS. Rapp and Timmis (1999) reported a higher mineralisation rate of 80% for 1,2,4-TCB in a soil inoculated with Burkholderiasp. Strain PS14. But these results cannot be directly com- pared with our data since the experiments of Rapp and Timmis (1999) were conducted at higher temperature (30  C) and the mineralisation was estimated by an indirect measurement of the evolved CO 2 . In addition, the quantification of non extractable residues was not performed. The mineralisation dynamics of 1,2,4-TCB in soil AS showed the typical pattern of co-metabolic degradation: first order kinetics and slow degradation rates ( Bending et al., 2003 ). The mineralisation curves of 1,2,4-TCB in soil CS and in inoculated soil AS however showed an exponential phase of degradation and a high rate of total mineralisation. The same mineralisation kinetic was found in previous experiments with 14 C-glucose (Ku ¨ hn et al., 2003, unpublished). This indicates a meta- bolic rather than a co-metabolic degradation. In soil CS the microbial community was influenced by a relative nitrogen deficiency as could be seen from the C/N ratio; the phosphorous content was also very low. Addition of NP fertiliser therefore led to a striking increase of the microbial respiration in this soil. The increase of microbial activity significantly enhanced the mineralisation rates in the first days of incubation. But when soil CS was not amended with NP the microbial community was also able to mineralise 1,2,4-TCB, though the microbial activity was not increased. Under these suboptimal nitrogen and phosphorous conditions the mineralisation rates were lower in the first days but after about 20 days the extent of mineralisation had reached the same values than in the NP amended soil CS. These results indicate that (1) the adapted microbial population in soil CS had a very strong mineralisation capability for 1,2,4-TCB which was even maintained under suboptimal nitrogen and phosphorous conditions when the total soil respiration was low, (2) additional nitrogen and phosphorous had only an effect in the first days where it strikingly enhanced the mineralisation, and (3) in a long-term range the extent of mineralisation was not dependent from additional NP sources. It seems that 14 CO 2 was produced until a plateau was reached above which no further mineralisation of 1,2,4-TCB could be measured. Additional NP nutrients had there- fore only a positive effect before the plateau was reached. On the other side, under suboptimal nitrogen and phosphorous conditions the microbial community was also able to mineralise 1,2,4-TCB up to the same CO 2 plateau, but in this case more time was needed till this plateau was reached. In inoculated soil AS no increase of the microbial activity could be observed but the mineralisation rate was significantly increased com- pared with non inoculated soil AS. This should be due to the change of the active microbial population by introducing the inoculum; it also indicates, that the degrading potential of this microbial consortium does not depend on the total soil respiration, as already dis- cussed above. In soil AS only low amounts of non extractable resi- dues were formed. The formation of non extractable residues is often explained by binding of a xenobiotic to the soil matrix, specially to the soil organic matter. Therefore it should be expected that the formation rates of non extractable residues should be similar in soil AS and soil CS since the chemical-physical properties of these soils did not differ very much. But in soil CSsig- nificantly higher amounts of non extractable residues were formed, moreover, the mineralisation of 1,2,4-TCB was very much higher than in soil AS. Thus, thestrong formation of non extractable residues is related to the microbial activity of 1,2,4-TCB degrading microbes. This becomes also evident by the fact, that after inocu- lation of soil AS the formation of non extractable resi- dues as well as 1,2,4-TCB mineralisation were enhanced. The much higher formation of non extractable residues in soil CS and in the inoculated soil AS could therefore be due to the binding or incorporation of 1,2,4-TCB and its degradation and mineralisation products not only to the soil matrix but also to the microbial biomass. Since 1,2,4-TCB is a volatile substance the biode- gradation studies were complicated by the volatility of this compound. We tried to overcome these difficulties by using a specially designed laboratory system. But it was not possible to avoid the losses completely, the established 14 C-mass balances varied from 75 to 100%. When the transformation rates of 1,2,4-TCB (miner- alisation and formation of bound residues) were high, the 14 C-recoveries were quite good, but with decreasing transformation rates, the 14 C-recoveries also decreased. Therefore, the losses could be due to the volatile parent compound which could be lost during incubation time and after removing the soil sample from the incubation flask for further analysis. Especially, handling of the soil after disconnection from the closed test system can cause considerable losses of the parent compoundas could be seen during the application process, where 18% of the initially applied 1,2,4-TCB was lost. Fur- thermore, the established 14 C-mass balances indicate that 1,2,4-TCB was mineralised by direct ring cleavage without formation of dechlorinated intermediates like dichlorobenzenes or monochlorobenzene. Otherwise, in 400 R.Schroll etal. / EnvironmentalPollution127 (2004)395–401 soil CS where 1,2,4-TCB was mineralised to a high extent, the formation of highly volatile dechlorination products during the mineralisation process should have resulted in lower 14 C-recoveries. Moreover the dechlor- ination process takes place under reductive conditions and starts only after a considerable lag phase, as pre- vious experiments have shown ( Brahushi et al., 2003, unpublished ). Establishing a 14 C mass balance is not only helpful to control the correct handling of the experi- mental set up but it also supports the overall evaluation of the behaviour of the investigated pollutant. The results of the current study indicate that the adapted microbial population of a soil from a 1,2,4-TCB contaminated site was able to mineralise 1,2,4-TCB in considerable amounts. When this adapted microbial community was transferred to another soil it conserved its degradation ability. The very low miner- alisation rates in an agricultural soil could therefore be considerably enhanced. References Aelion, C.M., Swindoll, C.M., Pfaender, F.K., 1987. Adaptation to and biodegradation of xenobiotic compounds by microbial com- munities from a pristine aquifer. Appl. Environ. Microbiol. 53, 2212–2217.
https://www.researchgate.net/publication/8991211_Biomineralisation_of_124-trichlorobenzene_in_soils_by_an_adapted_microbial_population?_sg%5B0%5D=started_experiment_milestone
Conceptual Assessment Framework for Forested Wetland Restoration: The Pen Branch Experience. Restoration of a Severely Impacted Riparian Wetland System - The Pen Branch Project (Journal Article) | OSTI.GOV The U.S. Department of Energy's Office of Scientific and Technical Information Title: Conceptual Assessment Framework for Forested Wetland Restoration: The Pen Branch Experience. Restoration of a Severely Impacted Riparian Wetland System - The Pen Branch Project Abstract Development of an assessment framework and indicators can be used to evaluate effectiveness of wetland restoration. Example of these include index of biotic integrity and the hydrogeomorphic method. Both approaches provide qualitative ranks. We propose a new method based on the EPA wetland research program. Similar to other methods, indexes are compared to reference communities; however, the comparisons are quantitative. In this paper we discuss the results of our framework using the Pen Branch riparian wetland system as an example. Authors: Kolka, R;Nelson, E A; Trettin, C C Publication Date: 2000-10-01 Research Org.: USDA Forest Service, Savannah River, New Ellenton, SC (US) Sponsoring Org.: (US) OSTI Identifier: 807723 DOE Contract Number: AI09-00SR22188 Resource Type: Journal Article Journal Name: Ecological Engineering Additional Journal Information: Journal Volume: 15; Journal Issue: 1; Other Information: PBD: 1 Oct 2000; Journal ID: ISSN 0925-8574 Country of Publication: United States Language: English Subject: 54 ENVIRONMENTAL SCIENCES; WETLANDS; FORESTS; LAND RECLAMATION; PERFORMANCE; EVALUATION; RESTORATION; RIPARIAN SYSTEMS; IBI; HGM Restoration of a Severely Impacted Riparian Wetland System-The Pen Branch Project Journal Article Barton, C; Nelson, E; Kolka, R; ... - Ecological Engineering The Pen Banch riparian wetland system was impacted by hot water releases from the reactor operations at the SRS. Several hundred acres of swamp and bottomland forest were destroyed and degraded as a result of thermal effects and sedimentation. The SRS developed a plan to restore the system based upon planting both early and last successional tree species. The goal was to develop a https://doi.org/10.1016/S0925-8574(99)00084-1 Use of fish community data to evaluate restoration success of a riparian stream. Journal Article From 1985 to 1988, stream and riparian habitats in Pen branch and Four Mile branch began recovering from deforestation caused by the previous release of hot water from nuclear reactors. The Pen branch corridor was replanted with wetland trees in 1995 to expedite recovery and restore the Pen branch ecosystem. Pen branch, Four Mile branch, and two relatively undisturbed streams were electrofished in 1995:1996 to determine how fish assemblages differed between the previously disturbed and undisturbed streams and whether such difference could be used to measure restoration success in Pen branch. Fish assemblages were analyzed using nonparametric multivariate statistical methods more » and the index of biotic integrity (IBI), a bioassessment method based on measurement of ecologically sensitive characteristics of fish assemblages. Many aspects of fish assemblage structure (e.g. species richness, disease incidence, taxonomic composition at the family level) did not differ between disturbed and undisturbed streams; however, the disturbed streams were characterized by higher densities of a number of species. These differences were successfully detected with the multivariate statistical methods; whereas, the IBI did not differ between most recovering and undisturbed sampling sites. Because fish assemblages are strongly influenced by instream habitat, and because instream habitat is strongly influenced by the riparian zone, fish assemblages can be used to measure restoration success. Nonparametric ordination methods may provide the most sensitive measure of progress towards restoration goals, although the IBI can be used during early stages of recovery to indicate when certain ecologically important aspects of structure and function in recovering streams have reached levels typical of undisturbed streams. « less Application of EPA wetland research program approach to a floodplain wetland restoration assessment. Journal Article Kolka, R.K., C.C. Trettin, E.A. Nelson, C.D. Barton, and D.E. Fletcher. 2002. Application of the EPA Wetland Research Program Approach to a floodplain wetland restoration assessment. J. Env. Monitoring & Restoration 1(1):37-51. Forested wetland restoration assessment is difficult because of the timeframe necessary for the development of a forest ecosystem. The development of a forested wetland ecosystem includes the recovery of hydrology, soils, vegetation, and faunal communities. To assess forested wetland restoration projects, measures need to be developed that are sensitive to early changes in community development and are predictive of future conditions. In this study we apply the EPS's more » Wetland Research Program's (WRP) approach to assess the recovery of two thermally altered riparian wetland systems in South Carolina. In one of the altered wetland systems, approximately 75% of the wetland was planted with bottomland tree seedlings in an effort to hasten recovery. Individual studies addressing hydrology, soils, vegetation, and faunal communities indicate variable recovery responses. « less https://doi.org/10.4029/2002jemrest1no13 Restoration of a forested wetland ecosystem in a thermally impacted stream corridor Conference Nelson, E; McKee, Jr, W; Dulohery, C The Savannah River Swamp is a 3,020 Ha forested wetland on the floodplain of the Savannah River and is located on the Department of Energy`s Savannah River Site (SRS). Major impacts to the swamp hydrology occurred with the completion of the production reactors and one coal-fired powerhouse at the SRS in the early 1950`s. Water was pumped from the Savannah River, through secondary heat exchangers of the reactors, and discharged into three of the tributary streams that flow into the swamp. This continued from 1954 to 1988 at various levels. The sustained increases in water volume resulted in overflow of more » the original stream banks and the creation of additional floodplains. Accompanying this was considerable erosion of the original stream corridor and deposition of a deep silt layer on the newly formed delta. Heated water was discharged directly into Pen Branch and water temperature in the stream often exceeded 50 C. The nearly continuous flood of the swamp, the thermal load of the water, and the heavy silting resulted in complete mortality of the original vegetation in large areas of the floodplain. Research has been ongoing to determine methods to reintroduce tree species characteristic of more mature forested wetlands. The goal of the restoration is to create structural and biological diversity in the forest canopy by establishing a mix of species typically present in riparian and wetland forests of the area. « less Operational restoration of the Pen Branch bottomland hardwood and swamp wetlands - the research setting Journal Article Nelson, E - Ecological Engineering The Savannah River Swamp is a 3020 Ha forested wetland on the floodplain of the Savannah River and is located on the Department of Energy's Savannah River Site (SRS) near Aiken, SC. Historically the swamp consisted of approximately 50 percent bald cypress-water tupelo stands, 40 percent mixed bottomland hardwood stands, and 10 percent shrub, marsh, and open water. Creek corridors were typical of Southeastern bottomland hardwood forests. The hydrology was controlled by flooding of the Savannah River and by flow from four creeks that drain into the swamp prior to flow into the Savannah River. Upstream dams have caused some more » alteration of the water levels and timing of flooding within the floodplain. Major impacts to the swamp hydrology occurred with the completion of the production reactors and one coal-fired powerhouse at the SRS in the early 1950's. Water was pumped from the Savannah River, through secondary heat exchangers of the reactors, and discharged into three of the tributary streams that flow into the swamp. Flow in one of the tributaries, Pen Branch, was typically 0.3 m3 s-1 (10-20) cfs prior to reactor pumping and 11.0 m3 s-1 (400 cfs) during pumping. This continued from 1954 to 1988 at various levels. The sustained increases in water volume resulted in overflow of the original stream banks and the creation of additional floodplains. Accompanying this was considerable erosion of the original stream corridor and deposition of a deep silt layer on the newly formed delta. Heated water was discharged directly into Pen Branch and water temperature in the stream often exceeded 65 degrees C. The nearly continuous flooding of the swamp, the thermal load of the water, and the heavy silting resulted in complete mortality of the original vegetation in large areas of the floodplain. In the years since pumping was reduced, early succession has begun in some affected areas. Most of this has been herbs, grasses, and shrubs. Areas that have seedlings are generally willow thickets that support a lower diversity of wildlife. No volunteer seedlings of heavy-seeded hardwoods or cypress have been found in the corridor areas. Research was conducted to determine methods to reintroduce tree species characteristic of more mature forested wetlands. Three restoration strategies were formulated to deal with the differing conditions of the Upper Corridor, the Lower Corridor, and the Delta regions of the impacted area. Site preparation and planting of each area with mixtures of tree species were carried out to speed the restoration of the ecosystem. Species composition and selection were altered based on the current and expected hydrological regimes that the reforestation areas will be experiencing. Because of the operational design of the restoration project, a research program naturally followed to document the success. Many of those efforts are detailed here. « less https://doi.org/10.1016/S0925-8574(99)00069-5
https://www.osti.gov/biblio/807723
(PDF) Prevalence and Predictors of Sexually Transmitted Infections in Hazardously-Drinking Incarcerated Women PDF | Incarcerated women are at high risk for sexually transmitted infections. Left untreated, these infections can have severe adverse health effects.... | Find, read and cite all the research you need on ResearchGate Prevalence and Predictors of Sexually Transmitted Infections in Hazardously-Drinking Incarcerated Women March 2012 Women & Health 52(2):119-34 DOI: 10.1080/03630242.2011.649396 Abstract Incarcerated women are at high risk for sexually transmitted infections. Left untreated, these infections can have severe adverse health effects. In this study the authors present prevalence rates of trichomonas, chlamydia, and gonorrhea, and factors related to having a sexually transmitted infection in a sample of 245 hazardously-drinking incarcerated women who reported heterosexual intercourse in the previous 3 months. Vaginal swabs were collected following the self-report baseline assessment. Participants averaged 34.0 (±8.8) years of age; 174 (71.3%) were non-Hispanic Caucasian, 47 (19.3%) were African-American, 17 (7.0%) were Hispanic, and 6 (2.5%) were of other racial or ethnic origins. Twenty-three percent of participants tested positive for chlamydia, trichomonas, or gonorrhea. Being African-American, more frequent sex with a casual partner, and reporting more than one male partner were significantly positively related to sexually transmitted infection, while more frequent sex with a main partner was inversely related. Due to the high rates of infection in this population, jail admission provides a public health opportunity to access a concentrated group of sexually transmitted infectious women. Sexually transmitted infection testing targeted at specific demographic factors, for instance younger age, will miss infected women. Risky sexual partnerships, as well as the benefit of maintaining stable main partnerships may be important topics during sexually transmitted infection prevention interventions. Content uploaded by Bradley Anderson Author content ... Low socioeconomic status and level of education was observed among female prisoners (8,(11)(12)(16)(17)(20)(21)(24)(25)28) . Prisoners come from marginalized social groups located in suburbs and urban centers (11,20) , from unstructured family nuclei (11,17,22) , belonging to racial and ethnic minorities (8,10,12,(14) (15) (18)(19)22,24,(27)(28). They are mostly young (11,13,20,27) , some were homeless (11)(12)24,28) , victims of domestic (12) and gender (11,25,28) violence, with a history of sexual and physical abuse or (8,(11)(12)17,22,26,28) who were unemployed or engaged in low-paid works (11,13,25) , which often determined their involvement with prostitution (10)(11)(14)(15)(16)18,26) with crime under the influence of affective-sexual partners (13) . ... ... Prisoners come from marginalized social groups located in suburbs and urban centers (11,20) , from unstructured family nuclei (11,17,22) , belonging to racial and ethnic minorities (8,10,12,(14)(15)(18)(19)22,24,(27)(28). They are mostly young (11,13,20,27) , some were homeless (11)(12)24,28) , victims of domestic (12) and gender (11,25,28) violence, with a history of sexual and physical abuse or (8,(11)(12)17,22,26,28) who were unemployed or engaged in low-paid works (11,13,25) , which often determined their involvement with prostitution (10)(11)(14) (15) (16)18,26) with crime under the influence of affective-sexual partners (13) . Imprisonment would happen mainly due to drug use and/or trafficking (8,(11)(12)15,(22)(23)26,28) , with probability of criminal recidivism (25,28) and difficulties of social reintegration due to postincarceration stigma (28) . ... ... They are mostly young (11,13,20,27) , some were homeless (11)(12)24,28) , victims of domestic (12) and gender (11,25,28) violence, with a history of sexual and physical abuse or (8,(11)(12)17,22,26,28) who were unemployed or engaged in low-paid works (11,13,25) , which often determined their involvement with prostitution (10)(11)(14)(15)(16)18,26) with crime under the influence of affective-sexual partners (13) . Imprisonment would happen mainly due to drug use and/or trafficking (8,(11)(12) 15, (22)(23)26,28) , with probability of criminal recidivism (25,28) and difficulties of social reintegration due to postincarceration stigma (28) . ... Sexual and reproductive health risk factors of imprisoned women: integrative review Objective to identify sexual and reproductive health risk factors related to health vulnerability of imprisoned women. Method integrative literature review held in Virtual Health Library databases in December 2016, using the strategy Population, Variables and Outcomes. A sample of 21 articles was obtained. Results there are risk factors related to sexual and reproductive health vulnerability that are enhanced by the absence and/or deficit of actions on health promotion, protection, recovery and rehabilitation in the prison context. Conclusion sexual and reproductive grievances of imprisoned women are related tosocial and programmatic individual risk factors. ... Incarcerated women are at high risk for sexually transmitted infections (STI), which if left untreated can lead to adverse complications such as preterm delivery, infertility, pelvic inflammatory diseases, ectopic pregnancy, and even increased HIV transmission (1, 2) . Overall, chlamydial infection, trichomoniasis, and gonorrhea are the most common STIs among American women (3), who are generally affected by STI at higher rates than men. ... ... Overall, incarcerated women are among the subpopulation of females at high risk for STIs. Recent data indicate that the prevalence of some STIs such as chlamydia and gonorrhea in female prisoners is much higher than the general population (2) . Commercial sex, elevated rates of substance use, exchanging drugs for sex, and hazardous drinking are quite common in detained women and are important risk factors for STIs. ... Prevalence of Commonly Encountered Sexually Transmitted Infections Among Imprisoned Incarcerated Women Background: Sexually transmitted infections are major causes of morbidity among incarcerated women. However, little is known about the prevalence of these infections among female prisoners in Iran. Objectives: This cross-sectional study, assessed the prevalence of sexually transmitted infections among a group of women imprisoned in Adelabad Prison, Shiraz, Iran. Patients and Methods: Over a 6-month period, we screened 129 female inmates in Adelabad Prison, Shiraz, Iran for sexually transmitted infections by appropriate clinical and routine laboratory assessments. Infected inmates were treated and followed up free of charge by the prison medical staff. Results: All inmates had evidence of at least one sexually transmitted infection. Chlamydial infection was the most common infection, which detected in 44 (34%) inmates, followed by candidiasis in 34 (26%), trichomoniasis in 26 (20%), syphilis in 8 (6%), and finally gonorrhea in 6 (4.5%) inmates. The least common infection was HIV infection, which was present in only 1 out of 129 subjects. In addition, 1 out of 58 (1.72%) serologically examined prisoners had hepatitis B, and 4 cases from 58 (7%) had evidence of hepatitis C, one of them was a drug addict and the other 3 had histories of past tattooing. Conclusions: Because of high rate of sexually transmitted infections (STIs) in incarcerated women, it is necessary to conduct a comprehensive screening program, treatment, follow-up, and partner notification in order to reduce the frequency of STIs in this high-risk, vulnerable group of females. ... ► Sexual and reproductive healthcare services: Women in prisons have a higher prevalence of sexually transmitted infections, such as chlamydia, gonorrhoea and HIV compared with men. 26 Integrating sexual and reproductive health strategies and programmes within prisons, such as information and education, ensuring the availability of safer sex materials, contraception and sexual health clinics 12 26 can help meet the aspirations of Target 3.7. ... Leaving no one behind in prison: Improving the health of people in prison as a key contributor to meeting the Sustainable Development Goals 2030 Mar 2021 Nasrul Ismail Audrey Lazaris Eamonn O'Moore Sunita Sturup-Toft Worldwide, approximately 11 million people are currently being held in prison, a number that has steadily grown since the turn of the 21st century. The prison population is more likely to suffer from physical and mental ailments both during and prior to their imprisonment due to poverty, social exclusion and chaotic lifestyles. Recognition of people in prison is noticeably absent from the Sustainable Development Goals (SDGs), despite the goals’ ethos of ‘leaving no one behind’. We present the first analysis of how improving the health of people in prison can contribute to achieving 15 SDGs. Relevant indicators are proposed to fulfil these goals while meeting the existing international prison health standards. We also assess the political, economic and social challenges, alongside the unparalleled COVID-19 pandemic that can thwart the realisation of the SDGs. To reach the ‘furthest behind first’, prison health must be at the forefront of the SDGs. ... Although few reports on behavioural interventions and STIs incidence exist [18], we are in agreement with the thought that reducing STIs-related risk behaviours among youth and other vulnerable population groups is essential for the effectiveness of any prevention programs [17, 19, 20,21,22,23,24]. However, optimization of developing countries' response to prevent the transmission of STIs requires both information and the capacity to use this information to build an efficient response. ... Chlamydia trachomatis, Human Immunodeficiency Virus (HIV) Distribution and Sexual Behaviors across Gender and Age Group in an African Setting Mar 2014 PLOS ONE Joel Fleury Djoba Siawaya The purpose of this study was to (1) describe the distribution of Chlamydia trachomatis (CT) and Human Immunodeficiency Virus (HIV) cases across gender and age groups in Libreville (Gabon); (2) examine Gabonese Sexually Transmitted Infections (STIs)-related risk behaviour. The sampled population was people attending the "Laboratoire National de Santé Plublique". Between 2007 and 2011, 14 667 and 9 542 people respectively, were tested for CT and HIV infections. 1 854 of them were tested for both infections. We calculated CT and HIV rates across gender and age groups. Also analysed was the groups' contribution to the general CT and HIV epidemiology. STIs-related risk behaviours were assessed in 224 men and 795 women (between July 2011 and March 2013) who agreed and answered a questionnaire including questions on their marital status, number of sex partners, sexual practices, history of STIs, sex frequency and condom use. Data showed a 24% dropped in the CT infection rate between 2007 and 2010, followed by a 14% increase in 2011. The HIV infection rates for the same period were between 15% and 16%. The risk of a CT-positive subject getting HIV is about 0.71 times the risk of a CT-negative subject. Young adult aged between 18 and 35 years old represented 65.2% of people who had STIs. 80% of women and 66% of men confessed to an inconsistent use of condoms. 11.6% of women and 48% of men declared having multiple sex partners. 61% of questioned women and 67% of men declared knowing their HIV status. In this Gabonese setting, the population-aged from18 to 35 years is the most affected by STIs. Other matters of concern are the inconsistent use of protection and sex with non-spousal or non-life partners. Assessing sexual behavior with self-report is essential to research on a variety of health topics, including pregnancy and infertility, sexually transmitted infections, and sexual health and functioning. Recent methodological research has provided new insights regarding the accuracy of self-reports of sexual behavior. We review these studies, paying particular attention to a promising new development: the use of computer-assisted assessments. The collection of sexual risk behavior data with computers has increased dramatically in recent years, but little is known about the accuracy of such assessments. We summarize the evidence, discuss methodological issues that arise in studies evaluating the accuracy of self-reports, and offer recommendations for future research. Background: Nationally representative surveys of chlamydia and gonorrhea are an important measure of disease burden and progress of screening programs. Objective: To measure chlamydia and gonorrhea prevalence in the United States. Design: Analysis of sexual history information and urine specimens collected in the National Health and Nutrition Examination Survey (NHANES), 1999-2002. Setting: U.S. civilian noninstitutionalized population as sampled by NHANES, 1999-2002. Participants: 6632 NHANES respondents. Measurements: Urine specimens were tested for chlamydia and gonorrhea. Results were weighted to represent the U.S. civilian, noninstitutionalized population between 14 and 39 years of age. Results: Prevalence of gonorrheal infection was 0.24% (95% Cl, 0.16% to 0.38%). Prevalence of gonorrheal infection was higher among non-Hispanic black persons (1.2% [Cl, 0.7% to 1.9%]) than among non-Hispanic white persons (0.07% [Cl, 0.02% to 0.24%]). Among those with gonorrheal infection, 46% also had chlamydial infection. Prevalence of chlamydial infection was 2.2% (Cl, 1.8% to 2.8%) and was similar between males (2.0% [Cl, 1.6% to 2.5%]) and females (2.5% [Cl, 1.8% to 3.4%]). Among females, the highest prevalence was in those age 14 to 19 years, whereas among males, it was highest in those age 14 to 29 years. Prevalence was higher among non-Hispanic black persons (6.4% [Cl, 5.4% to 7.5%]) than non-Hispanic white persons (1.5% [Cl, 1.0% to 2.4%]). Among females with a history of gonorrhea or chlamydia in the previous 12 months, chlamydia prevalence was 16.7% (Cl, 5.5% to 50.7%). Limitations: The specificity of urine-based assays for chlamydia and gonorrhea is limited, and the possible misclassification of sexual experience status may have affected the accuracy of some estimates. Conclusions: The findings support current recommendations to screen sexually active females age 25 years or younger for chlamydia, to retest infected females for chlamydial infection, and to co-treat individuals with gonorrhea for chlamydia. Background: No unbiased estimates of the rates of psychiatric disorder among women prison inmates are available. Nonetheless, available data suggest that some psychiatric disorders are prevalent in this population. The objective of the study was to determine the rates, risk factors, and outcomes of specific psychiatric disorders among women prison inmates. Methods: A virtual census of women felons (N=805) entering prison in North Carolina was assessed using in-person interviews. Assessments were conducted for 8 disorders, using the Composite International Diagnostic Interview as the primary assessment measure. For validation purposes, one quarter of the inmates were reassessed for 2 of these disorders, using structured clinical interviews. Results: Inmates were found to have high rates of substance abuse and dependence and antisocial and borderline personality disorders compared with women in community epidemiologic studies. Rates among inmates were also somewhat elevated for mood disorders but not for anxiety disorders. The rate of reports of lifetime exposure to traumatic events was also high. Rates of disorder tended to be higher among white than among African American women. Conclusion: High rates of substance abuse, psychiatric disorder, and psychological distress associated with exposure to traumatic events suggest that women in prison have a need for treatment for substance abuse and other mental health problems.
https://www.researchgate.net/publication/223994179_Prevalence_and_Predictors_of_Sexually_Transmitted_Infections_in_Hazardously-Drinking_Incarcerated_Women
Condensed Matter | Free Full-Text | Investigating the Morphology, Optical, and Thermal Properties of Multiphase-TiO2/MAPbI3 Heterogeneous Thin-Films for Solar Cell Applications The present study evaluates the effect of mesoporous multiphase titanium dioxide (TiO2) nanoparticles (NPs) as an electron transporting layer and investigates the influence of phase composition on the perovskite solar cell (PSC) performances. This study also aims to evaluate PSC performance using conductive silver ink as an alternative counter electrode. The heterogeneous PSC thin-film solar cells were successfully fabricated and assembled by using a simple a doctor blade and two-step spin coating methods under ambient conditions. Scanning electron microscopy (SEM) micrograph images investigate methyl ammonium lead iodide (MAPbI3) crystal formation on the mesoporous TiO2 surface structure. Energy-dispersive x-ray spectroscopy (EDX) spectra reveal excellent qualitative and quantitative analysis corresponding to the SEM images in the TiO2/MAPbI3 heterogeneous thin films. Thermogravimetric analysis (TGA) characterization reveals that the TiO2/MAPbI3 thin films are thermally stable recording a maximum of 15.7% mass loss at 800 °C elevated temperatures. Photoluminescence spectroscopy (PL) characterized the effect of multiphase TiO2 phase transformation on the TiO2/MAPbI3 recombination efficiencies. A maximum of 6% power conversion efficiency (PCE) with the open-circuit voltage (Voc) of 0.58 ± 0.02 V and short circuit current (Jsc) of 3.89 ± 0.17 mAcm−2 was achieved for devices with an active area of 3 × 10−4 m2 demonstrating that the synthesized multiphase TiO2 nanoparticles are promising for large surface area manufacturing. Therefore, it is apparent that multiphase TiO2 NPs play a significant role in the performance of the final device. Investigating the Morphology, Optical, and Thermal Properties of Multiphase-TiO 2 /MAPbI 3 Heterogeneous Thin-Films for Solar Cell Applications by Thembinkosi D. Malevu 1,* , Tshwafo E. Motaung 2,3 , Lehlohonolo F. Koao 5 , Teboho P. Mokoena 1 and Motlalepula R. Mhlongo 1 1 Department of Physics, Sefako Makgatho Health Sciences University, P.O. Box 94, Medunsa 0204, South Africa 2 Department of Chemistry, Sefako Makgatho Health Sciences University, P.O. Box 235, Medunsa 0204, South Africa 3 Department of Chemistry, School of Science, College of Science Engineering and Technology, University of South Africa, Preller Street, Muckleneuk Ridge, City of Tshwane, P.O. Box 392, Unisa 0003, South Africa 4 Department of Chemical and Physical Sciences, Walter Sisulu University, Private Bag X1, Mthatha 5117, South Africa 5 Department of Physics, University of the Free State (Qwa Qwa Campus), Private Bag X13, Phuthaditjhaba 9866, South Africa * Author to whom correspondence should be addressed. Condens. Matter 2022 , 7 (2), 39; https://doi.org/10.3390/condmat7020039 Received: 11 April 2022 / Revised: 9 May 2022 / Accepted: 11 May 2022 / Published: 6 June 2022 : The present study evaluates the effect of mesoporous multiphase titanium dioxide (TiO 2 ) nanoparticles (NPs) as an electron transporting layer and investigates the influence of phase composition on the perovskite solar cell (PSC) performances. This study also aims to evaluate PSC performance using conductive silver ink as an alternative counter electrode. The heterogeneous PSC thin-film solar cells were successfully fabricated and assembled by using a simple a doctor blade and two-step spin coating methods under ambient conditions. Scanning electron microscopy (SEM) micrograph images investigate methyl ammonium lead iodide (MAPbI 3 ) crystal formation on the mesoporous TiO 2 surface structure. Energy-dispersive x-ray spectroscopy (EDX) spectra reveal excellent qualitative and quantitative analysis corresponding to the SEM images in the TiO 2 /MAPbI 3 heterogeneous thin films. Thermogravimetric analysis (TGA) characterization reveals that the TiO 2 /MAPbI 3 thin films are thermally stable recording a maximum of 15.7% mass loss at 800 °C elevated temperatures. Photoluminescence spectroscopy (PL) characterized the effect of multiphase TiO 2 phase transformation on the TiO 2 /MAPbI 3 recombination efficiencies. A maximum of 6% power conversion efficiency (PCE) with the open-circuit voltage (Voc) of 0.58 ± 0.02 V and short circuit current (Jsc) of 3.89 ± 0.17 mAcm − 2 was achieved for devices with an active area of 3 × 10 −4 m 2 demonstrating that the synthesized multiphase TiO 2 nanoparticles are promising for large surface area manufacturing. Therefore, it is apparent that multiphase TiO 2 NPs play a significant role in the performance of the final device. Keywords: multiphase TiO 2 ; mesoporous TiO 2 ; perovskite solar cells ; doctor blade ; conductive silver ink 1. Introduction P- and n-type semiconducting transition metal oxides are extensively studied and put in use in third-generation solar cells ranging from dye-sensitized solar cells (DSSCs), quantum dot solar cells (QDSCs), organic solar cells (OSCs), and perovskite solar cells (PSCs) [ 1 , 2 , 3 ]. Thin films of TiO 2 , ZnO, V 2 O 5 , MoO, CuO, and NiO 2 are used due to their nanostructural properties to facilitate charge extraction and transport from photoactive hybrid materials [ 4 , 5 , 6 , 7 ]. The mesoporous structure in titanium dioxide (TiO 2 ) makes it a successful n-type photoanode electrode in photovoltaics (PVs). This unique TiO 2 morphology appears to serve as a host/absorber matrix for light active materials on its surface in DSSCs, QDSCs, and PSCs, which increases the metal oxide/light active material intermediate contact [ 8 , 9 ]. Tailoring the structure, morphology, and optical properties of metal oxides is key to optimizing the performance of solar cell devices [ 10 , 11 , 12 ]. Changes in TiO 2 merit properties such as phase composition, degree of crystallinity, porosity, crystalline size, particle size, and bandgap structure are significant to improving hybrid solar cell’s photocurrent, open-circuit voltage, and energy conversion efficiencies. Similar to DSSCs, TiO 2 thin films are coated over conductive glass substrates, annealed, and stained with a light sensitive ABX 3 perovskite material in PSCs. The annealing process is known to transform TiO 2 into a crystalline and conductive electron transport layer (ETL), remove residual impurities, precursor solvents, and encourage brookite, anatase, and rutile phases formation [ 13 ]. In addition, significant research has demonstrated that annealing alters TiO 2 merit properties, which subsequently influence the metal oxide/light active interface properties [ 13 , 14 ]. In PVs anatase, TiO 2 is the most preferred phase due to its higher open-circuit voltage, photoactivity, and surface area than rutile-based PV cells [ 15 ]. An important concept that has not received much attention is the use of mixed-phase (anatase: rutile) TiO 2 nanoparticles (NPs) in PSCs. Extensive research on mixed-phase TiO 2 photoanode has been carried out in DSSCs. The majority of these studies observe synergy at less than 20% rutile phase formation [ 16 , 17 ]. Material characterization results reveal that changes in phase composition bring about changes in TiO 2 merit properties such as crystallinity, morphology, and optical properties of the photoanode [ 18 ]. The authors [ 14 ] have previously reported similar changes and are included in the article to further demonstrate the influence of multiphase-TiO 2 ETL on PSCs performance. Existing studies on mixed-phase TiO 2 achieve phase composition through a mixture of two-phase different titanium precursors, (e.g., P25 and P90), the addition of phase controlling agents/additives, (e.g., CH 3 COOH, EDTA, and (NH 4 ) 2 SO), and annealing TiO 2 NPs [ 16 , 17 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Li et al. [ 17 ] fabricated mixed-phase TiO 2 photoelectrodes based on phase pure anatase and rutile TiO 2 . The authors’ results demonstrate that the addition of small rutile phase content into anatase enhances the photoelectrode absorption coefficient, improving the photocurrent density and efficiency in comparison to the phase pure PV cells. In addition, Yun et al. [ 16 ] prepared mixed-phase TiO 2 NPs by (NH 4 ) 2 SO 2 hydrolysis. The concentration of the sulfate ion successfully tunes anatase and rutile phase composition. The authors’ characterization results indicate that the improved photocurrent and efficiencies in comparison to pure phase devices are attributed to high light scattering by large rutile particles. However, large amounts of rutile phase content decrease surface area and as a consequence dramatically reduce the device’s performance. In similar research work, Ruan et al. [ 19 ] supplement the explanation of synergy in mixed-phase TiO 2 by symbiosis in anatase and rutile surface morphologies, which facilitates maximum interparticle charge transfer. The above synthesis of mixed-phase TiO 2 NPs results in two distinctive rod-like and spherical morphologies associated with rutile and anatase phases, respectively, with rutile morphology relative to anatase decreasing solar cell performances due to its low surface area and packing structure both phenomena decreasing the electron collection in the devices. Earlier studies conducted by the authors Lekesi et al. [ 28 ] on the formation of multiphase titanium dioxide (TiO 2 ) suggested that increasing the annealing temperature of TiO 2 brings about changes in material merit properties such as porosity, particle size, crystallinity, and optical properties. Without any further treatment, the as-synthesized multiphase titanium dioxide (TiO 2 ) was employed in this study and used as is to fabricate heterogeneous thin films of TiO 2 /MAPbI 3 . Therefore, the main aim of this work was to use the mesoporous multiphase-TiO 2 NPs to investigate the influence of phase composition on PSC performance, and additionally, to evaluate the PSC performance using conductive silver ink as an alternative counter electrode. The phase transformation is achieved through annealing TiO 2 NPs from 200 to 1200 °C. Scanning electron microscopy coupled with energy-dispersive x-ray spectroscopy (SEM-EDX) was used to investigate the perovskite MAPbI 3 crystal formation and interaction with TiO 2 ETL. Fourier transform infrared spectroscopy (FT-IR) was used to confirm functional groups within the multiphase-TiO 2 /MAPbI 3 heterogeneous thin films. Thermogravimetric analysis (TGA) was used to determine the thermal behavior and confirm the existence of heterogeneous TiO 2 and MAPbI 3 mixture from the TGA degradations steps within a temperature range of 0 to 800 °C. Photoluminescence spectroscopy (PL) was used to study recombination efficiencies. The increasing TiO 2 particle size and rutile phase increase photoexcitation and efficient electron extraction from the MAPbI 3 light active material. A detailed explanation of the effect of annealing/phase composition on the PSC IV performance is given. Maximum efficiency of up to 6.7% is reported, attributed to factors discussed in SEM and PL. 2. Methods Perovskite Solar Cell (PSCs) Device Fabrication Indium-doped tin oxide (ITO) glass substrates (Sigma-Aldrich, Burlington, MA, USA) were first cleaned with a detergent and ultrasonicated three times using water, isopropanol, and ethanol for 20 min separately. The glass substrates were later allowed to dry at ambient atmosphere and thereafter subjected to Ultraviolet (UV)–Ozone cleaning for a period of 15 min. To form a dense compact TiO 2 blocking layer, the UV–Ozone-cleaned substrates were coated with a 0.15 M titanium diisopropoxide bis(acetylacetonate) (75% in isopropanol, Sigma-Aldrich) in 1-butanol by spin-coating at 2000 rpm for 20 s which were then heated at 100 °C for 5 min. After the coated glass substrates were allowed to cool at room temperature, the process was repeated two times using a 0.3 M titanium diisopropoxide bis(acetylacetonate). Following the three-times coating of titanium diisopropoxide bis(acetylacetonate) the glass substrates were then heated at 250 °C for 15 min and allowed to cool at room temperature. A few micrometers thick layer of mesoporous-TiO 2 photoelectrode was formed from a paste of the authors’ previously synthesized TiO 2 [ 28 ]. The micrometer thick layers were coated over the compact layer using the doctor blade technique thereafter the substrates were heated at 250 °C for 45 min. From here the substrates/photoelectrodes were treated with a 0.02 M TiCl 4 (98%, Sigma-Aldrich) solution maintained at 80 °C for 10 min, washed with deionized water, and dried at 100 °C in an open atmosphere. A single halide perovskite layer of CH 3 NH 3 PbI 3 -(MAPbI 3 ) was formed by a two-step spin coating of PbI 2 and MAI at ambient conditions (relative humidity = 45–60%) to form TiO 2 /MAPbI 3 heterogeneous thin films. Firstly, a solution of 0.02 mL of 1 M PbI 2 (4.61 g) in a solvent mixture of dimethyl formamide DMF: dimethyl sulfoxide DMSO (3:1) prepared at 70 °C was spin-coated over the mesoporous TiO 2 layers at 3000 rpm for 10 s without loading time. The ITO/c-TiO 2 /m-TiO 2 /PbI 2 glass substrates were then dried at 100 °C for 10 min and allowed to cool to room temperature. The perovskite layer was completed by spin-coating 0.2 mL of 0.038 M CH 3 NH 3 I at 4000 rpm for 20 s with a loading time of 20 s. The ITO/c-TiO 2 /m-TiO 2 /MAPbI 3 glass substrates were then dried at 100 °C for 10 min. A 0.02 mL solution of spiro-MeOTAD was spin-coated over the perovskite bearing substrated at 3500 rpm for 35 s. The spiro-MeOTAD deposited solution was obtained by dissolving 0.072 g of spiro-MeOTAD (Sigma-Aldrich) in 1 mL chlorobenzene (Sigma-Aldrich) solvent. This was followed by the addition of 0.029 mL 4- tert -butyl pyridine (Sigma-Aldrich) and 0.018 mL (0.52 g) lithium bis(trifluoromethanesulfonyl)imide in 1 mL acetonitrile (Sigma-Aldrich) solutions. The counter electrode was obtained by using silver (Ag) ink on an opposite ITO substrate. Approximately 80% of the ITO substrate was covered with a deposition mask and a conductive Ag ink (Sigma-Aldrich) was deposited over the exposed area via doctor blade technique. The solar cells were assembled by preheating the TiO 2 coated substrates at 100 °C for 5 min and thereafter clamped with the opposite Ag coated electrodes. The fabricated cells were then heated at 100 °C for 15 min to form solar cells with device architecture of ITO/c-TiO 2 /m-TiO 2 /MAPbI 3 /Ag/ITO. A total of six (6) devices are reported by varying only the mesoporous TiO 2 electron transport layer and the remaining layers are kept constant. Figure 1 shows the fabrication steps of the different TiO2/MAPbI3 films. 3. Characterization To determine the surface morphology of TiO 2 /MAPbI 3 heterogeneous thin-films, a TESCAN VEGAN3 scanning electron microscopy (OXFORD X-MAX N ) coupled with EDX operated at 20 kV was used and the analysis was done at room temperature. The surface of the samples was sputter-coated with carbon for 9.9 s to produce a conductive coating on the samples. To characterize the thermal behavior of the samples Perkin-Elmer STA6000 thermogravimetric analyzer (TGA) was used. A total of 20–25 mg of the photoanode/perovskite was obtained by scraping the TiO 2 /MAPbI 3 heterogeneous thin films off the ITO conductive substrate. The samples were heated at 10 °C min −1 from ambient to 800 °C under 20 mL min −1 nitrogen flow. In this work, a Perkin-Elmer Spectrum 100 Fourier transform infrared (FT-IR) spectroscope fitted with an attenuated total reflection (ATR) detector was used. FT-IR spectrometer was used in this study to identify functional groups in the TiO 2 /MAPbI 3 heterogeneous thin films. The infrared (IR) spectra were recorded between 4000 and 650 cm −1 at a resolution of 4 cm −1 . Photoluminescence spectroscopy (PL) characterization was performed on as-prepared TiO 2 nanopowder, annealed TiO 2 nanopowder, and TiO 2 /MAPbI 3 heterogeneous films under a Carry Eclipse Fluorescence spectrophotometer with a 150 W xenon lamp (λ ex = 238 nm). The electrical properties of the final devices with an active area of 3 cm 2 = 3 × 10 −4 m 2 were measured using Newport Oriel LCS-100 solar simulator and Keithley source meter (Keithley 2450) under AM1.5 G and 1000 W/m 2 standard irradiation test conditions calibrated from a standard Si-based solar cell. 4. Results and Discussion 4.1. Morphology and Chemical Analysis Figure 2 a–f shows low-magnification SEM surface morphology of the as-prep TiO 2 /MAPbI 3 and annealed heterogeneous thin films, respectively. It should be mentioned that the low magnification was used in this work to allow us to have an overview of how the surface looks following the deposition of MAPbI 3 solution on top of multiphase TiO 2 nanomaterials. The surface images depict that annealing the multiphase-TiO 2 nanopowder has a strong influence on MAPbI 3 crystals formation over the TiO 2 surface structure. The images show two distinctive morphologies; (1) small particles (assumed to be nanometer-sized TiO 2 nanoparticles (NPs)) and (2) relatively large particles (assumed to be MAPbI 3 crystals). Similar perovskite crystal morphology is reported by Christians et al. [ 22 ] from the two-step MAPbI 3 deposition method. In Figure 1 1t is observed that the increased annealing temperature in the multiphase-TiO 2 NPs encourages a non-uniform MAPbI 3 crystal dispersion increasing the distribution over the nanoporous TiO 2 surface. Im et al. [ 23 ] demonstrated comparable perovskite crystal growth. From all the SEM images the MAPbI 3 crystals are of the same size due to the consistent preparation method. Figure 3 shows high-magnification SEM micrographs and the corresponding SEM-EDX micrographs of TiO 2 /MAPbI 3 heterogeneous thin-films used to investigate MAPbI 3 crystal formation onto the mesoporous TiO 2 NPs on a particular/selected region marked by white dotted squares in Figure 2 a. The observed morphology from the magnified SEM image in Figure 3 a shows an incomplete or initial stage of perovskite crystal formation. This is confirmed by the corresponding SEM-EDX micrograph presented in Figure 3 b demonstrating the presence of C, Pb, and I perovskite main elements. It is anticipated in this study that the TiO 2 surface charging leads to possible perovskite nucleating (or crystallization) sites depending on the MAPbI 3 surface charging density leading to the heterogeneous morphology shown in Figure 3 c illustrating a cluster of crystals emerging from the surface of the TiO 2 nanoporous host material. Based on the observed MAPbI 3 crystal morphology, it is noted that there exists a preferred MAPbI 3 orientated crystal growth that propagates away from a fixed-point source justifying the proposed localized nucleating sites discussed above. Figure 3 d demonstrates the presence of perovskite main elements similarly to Figure 3 b. Figure 4 a,b shows EDX spectra of as-prepared TiO 2 /MAPbI 3 , 200°C/MAPbI 3, and annealed MAPbI 3 heterogeneous thin films. In these results, all the expected elements such as Ti, O, Pb, and I were attained; however, the C element emerged from the carbon tape on which the samples were mounted. The EDX peak position (keV) and intensities (cps/eV) values provide excellent qualitative and quantitative analysis of the elements present in the TiO 2 /MAPbI 3 heterogeneous thin films, respectively, consistent with SEM surface analysis. There were no significant differences worth mentioning in the proportion of expected elements in any of the annealed samples. The weight percent of Ti, O, Pb, and I elements obtained from EDX is nearly stoichiometric. 4.2. Fourier Transform Infrared Spectroscopy FT-IR spectroscopy was used to investigate the compatibility between the TiO 2 NPs and MAPbI 3 crystal in the heterogeneous thin films. Figure 5 presents FT-IR spectra of the heterogeneous TiO 2 /MAPbI 3 thin films. The activity of the IR-spectra was recorded between 4000 to 500 wavenumber regions. Vibrational modes from the heterogeneous thin films centered at 2902, 2804, 1703, and 709 cm −1 were identified and correlated with SEM surface images. The large absorption bands located at low annealing temperatures at 2902, 2804, and 1703 cm −1 are associated with low compatibility between the TiO 2 NPs and MAPbI 3 crystals. However, these vibrational bands systematically decrease with increasing TiO 2 annealing temperature, indicating that the interface contact compatibility in the heterogeneous thin films is improved. This can be successfully correlated with the increase in surface coverage from the SEM images. The appearance of a new vibrational mode located at 709 cm −1 substantiates enhanced compatibility, indicating that a good interface contact has been established. 4.3. Thermogravimetric Analysis To understand the thermal behavior and determine the degradation steps from the TiO 2 /MAPbI 3 perovskite heterogeneous thin films TGA analysis was performed by heating the samples from ambient temperature to 800 °C in triplicate, average values are reported in Table 1 . From the percentage mass loss in Figure 6 a, it is apparent that all the heterogeneous thin films are thermally stable, recording a maximum mass loss percentage of 15.7% at high temperatures of up to 800 °C. The as-prep TiO 2 /MAPbI 3 heterogeneous thin films experience the highest mass loss, recording a final residual mass percent of 84.3%. The remaining heterogeneous thin films increase systematically with increasing annealing temperature, exhibiting mass residues greater than 84.3%. A minimum of 2.2% mass loss is recorded for the 1200 °C/MAPbI 3 heterogeneous thin films. This shows that annealing of the TiO 2 nanopowder removes temperature-initiated degrading agents, resulting in thermally stable heterogeneous films. This observation is further depicted by the decreasing peak intensities in the DTGA graphs in Figure 6 b. This systematic increase in the residual mass % in the heterogeneous films is further correlated to the TiO 2 phase transformation. TiO 2 NPs are naturally characterized by thermal transitions from the metastable phases to the stable rutile phase. Therefore, samples annealed at higher temperatures possess the thermodynamically stable rutile phase, whereas samples at lower annealing temperatures are metastable anatase phases. Hence, the 2.2% mass loss belongs to the heterogeneous samples bearing more stable-TiO 2 NPs. In Figure 6 a,b TiO 2 /MAPbI 3 heterogeneous thin films decompose through three degradation mechanisms located at temperatures ≥ 106, 438, and 513 °C. The first and small degradation step located at ~106 °C is associated with the evaporation of absorbed water molecules on the surface of TiO 2 NPs, the second degradation step approximated at 438 °C is associated with the characteristic TiO 2 anatase to rutile phase transition [ 24 , 25 ]. As expected in both events, the mass loss % is significantly reduced with increasing annealing temperature as outlined above and summarized in Table 1 . The third degradation step results from the decomposition of the MAPbI 3 perovskite by desorption of volatile MAI organic group [ 26 ]. 4.4. Photoluminescence Spectroscopy Photoluminescence (PL) is used to characterize photogenerated recombination pathways caused by defect levels within the bandgap structure of a semiconductor and the resulting PL peak emissions indicate the recombination of excitons, electrons, and holes between the conduction band and valence band. TiO 2 NPs are characterized by PL peak emissions caused by oxygen vacancies, surface states, and free and bound exciton recombinations [ 20 , 21 , 27 ]. The emission spectra in Figure 7 a–c present PL peak emissions in the 300–700 nm range obtained from the excitation wavelength of λ ex = 238 nm for the as-prep TiO 2 nanopowder, annealed TiO 2 nanopowders, and as-prep TiO 2 /MAPbI 3 and annealed heterogeneous thin films. The peak emissions were analyzed to investigate the effect of annealing/phase transformation on the recombination efficiencies. The deconvoluted gaussian fit for the as-prep TiO 2 nanopowder in Figure 7 a shows characteristic peak emissions centered at λ em = 426, 466, 501, and 537 nm, a similar PL spectrum has previously been reported by Tsega et al. [ 27 ] and Acchutharaman et al. [ 21 ]. The prominent emissions located at 426 and 466 nm are associated with the oxygen vacancies and surface state dominant defect levels in the TiO 2 forbidden gap, whereas the shoulder peak emissions at high wavelengths of 501 and 537 nm are associated with the free edge and bound exciton minority recombinations. Figure 7 b demonstrates the effect of annealing multiphase-TiO 2 on the material’s recombination rates, insert of Figure 7 b (normalized peak intensities) presents similar peak emissions reported in Figure 6 a indicating that throughout the annealing process the peak emissions result from intrinsic trapping sites within the forbidden gap of multiphase-TiO 2 . From Figure 7 b, it is observed that by increasing annealing temperature, the multiphase-TiO 2 NPs undergo PL quenching. The observed luminescence quenching may be attributed to several factors, including the presence of trap centers, grain boundary defects, and the band structure thermal quenching effect. In this study, the band structure thermal quenching is observed indicated by the decreasing trend in peak intensities of the samples as follows; from the samples: as-prep TiO 2 → 200 °C → 400 °C. This indicates that the intrinsic recombination rates (or concentration of defect levels) from oxygen vacancies, surface states, and excitons are significantly reduced. A similar observation has been reported by Fan et al. [ 20 ] in mixed-phase TiO 2 NPs and is ascribed to the increase in TiO 2 degree of crystallinity and the desorption of oxygen molecules reducing TiO 2 dominant defect levels. However, with a further increase in annealing temperature, a counteractive phenomenon emerges, substantially increasing the peak intensities dramatically. This apparent change in behavior from the PL peak emissions is attributed to the multiphase-TiO 2 phase transition and an increase in TiO 2 particle size. Comparable results are reported by Yun et al. [ 16 ] and Ruan et al. [ 19 ] demonstrating that more rutile phase formation and large particle size result in a low electron mobile phase and increased light-scattering, respectively, providing an efficient charge carrier recombination pathway. Figure 7 c depicts PL peak emissions from the as-prep TiO 2 /MAPbI 3 and annealed heterogeneous thin films. A new dominant peak emission in all the heterogeneous films located at 540 nm appears. This shows that an intermediate contact is established between the ETLs and the light active material; therefore, such recombination rate is attributed to TiO 2 ETL and MAPbI 3 interface electron decaying pathway. For comparison, it is observed that all the maximum peak intensities of the TiO 2 /MAPbI 3 heterogeneous thin films are significantly reduced when compared to the maximum peak intensity of the as-prep TiO 2 nanopowder reported in Figure 7 a,b. This behavior may indicate that the incorporation of the light active MAPbI 3 perovskite material encourages maximum electron collection as a result of minimum photon emissions. A systematic decrease in TiO 2 /MAPbI 3 PL peak emission is observed with increasing annealing temperature/rutile phase content. This unusual trend highlights the synergistic effect of the multiphase-TiO 2 material influencing the overall photogenerated electron collection. The synergy results from the large photon scattering caused by the large particle size, which contributes to large photoexcitation in the perovskite material. 4.5. Electrical Characterization Figure 8 depicts a simplified schematic image of the devices. Figure 9 shows IV characterization curves measured under AM1.5G and 1000 W/m 2 standard illumination conditions. Table 2 summarizes electrical average parameter values with standard deviations from the three best cells for each sample. The power conversion efficiency of the devices given in Table 2 is calculated from Equation (1). From the IV curves in Figure 9 and Table 2 , it is observed that there is a prominent increase in current density (J sc ) and power conversion efficiency (ղ) from the PSCs with increasing rutile phase content and annealing temperature. This observation is correlated with the increasing MAPbI 3 surface coverage morphology (SEM) over the large multiphase-TiO 2 NPs, and the evident decrease in PL in Figure 7 c, resulting in enhanced J sc and ղ. This indicates that the increase in the rutile phase establishes an efficient electron transfer from the photoexcited perovskite material into the conduction band of the anatase phase. A maximum of 6.7% efficiency is achieved for the solar cells fabricated from the 1000 °C/MAPbI 3 heterogeneous thin films. Therefore, the IV characterization demonstrates that although the rutile phase is characterized by slow electron mobility resulting in increased multiphase-TiO 2 recombination rates as shown in Figure 6 b, the increasing PSC performance with increasing rutile content demonstrates that rutile is a high electron harvesting phase that extracts maximum photogenerated electrons from the perovskite material into the more electron mobile anatase phase decreasing the recombination as shown by Figure 7 c. This is followed by a significant decrease to 5.1% efficiencies as rutile becomes the more dominant phase indicating that phase optimization in the multiphase-TiO 2 NPs is required for optimal PSC performances. ղ = V oc · J sc · FF P in = V oc · J sc · FF A · 1000 W / m (1) Equation (1) is used in the calculation of the power conversion efficiency (ղ), whereby V oc represents open-circuit voltage, J sc represents short circuit current density, FF represents the fill factor, A represents the active area of the solar cells, and P in represents the maximum power from the solar simulator lamp. 5. Conclusions In this study, the use of multiphase TiO 2 nanoparticles proved to be an excellent mediator for maximum electron collection of the light active MAPbI 3 perovskite material to the ITO glass substrate. Heterogeneous thin films of TiO 2 and MAPbI 3 for solar cells were successfully fabricated from doctor blade and two-step spin coating methods. In this work, the silver conductive ink was used as a counter electrode. The SEM-EDX micrographs reveal that the MAPbI 3 crystal formation mechanism involved TiO 2 pore filling (nucleation) followed by crystallization (growth) during the evaporation of the deposition solvents. The thermal analysis reveals that the TiO 2 /MAPbI 3 thin films are thermally stable, recording a maximum of 15.7% mass loss at elevated temperatures. A systematic decrease in TiO 2 /MAPbI 3 PL peak emission is observed with increasing annealing temperature/rutile phase content. This unusual trend highlights synergy from the multiphase-TiO 2 material influencing the overall photogenerated electron collection. Finally, PSCs of device structure ITO/c-TiO 2 /m-TiO 2 /MAPbI 3 /Spiro-MeoTAD/Conductive Ag ink/ITO were fabricated and their performance was evaluated using the Keithley solar simulator. 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Schematic scheme representing steps involved in the fabricated device. Figure 2. Low-magnification SEM micrographs presenting the surface morphology of the ( a ) as-prep TiO 2 /MAPbI 3 , ( b ) 200 °C/MAPbI 3 ( c ) 400 °C/MAPbI 3, ( d ) 800 °C/MAPbI 3, ( e ) 1000 °C/MAPbI 3 , and ( f ) 1200 °C/MAPbI 3 heterogeneous thin-films. Figure 2. Low-magnification SEM micrographs presenting the surface morphology of the ( a ) as-prep TiO 2 /MAPbI 3 , ( b ) 200 °C/MAPbI 3 ( c ) 400 °C/MAPbI 3, ( d ) 800 °C/MAPbI 3, ( e ) 1000 °C/MAPbI 3 , and ( f ) 1200 °C/MAPbI 3 heterogeneous thin-films. Figure 3. High-magnification SEM micrographs illustrating ( a ) surface morphology of as-prep TiO 2 /MAPbI 3 interaction on ITO substrate, corresponding ( b ) SEM-EDX mapping image, ( c ) heterogeneous morphology interaction of MAPbI 3 nanocrystals embedded within TiO 2 nanopores, and corresponding ( d ) SEM-EDX image. Figure 4. ( a , b ) Shows EDX spectra of as prepared TiO 2 /MAPbI 3 and annealed 200 °C/MAPbI 3 heterogeneous thin films. Figure 4. ( a , b ) Shows EDX spectra of as prepared TiO 2 /MAPbI 3 and annealed 200 °C/MAPbI 3 heterogeneous thin films. Figure 5. FT-IR spectra of the heterogeneous TiO 2 /MAPbI 3 thin films. Figure 5. FT-IR spectra of the heterogeneous TiO 2 /MAPbI 3 thin films. Figure 6. ( a ) TGA and ( b ) DTGA graphs present the effect of annealing TiO 2 NPs on the thermal degradation behavior of the resulting TiO 2 /MAPbI 3 heterogeneous thin films. Figure 6. ( a ) TGA and ( b ) DTGA graphs present the effect of annealing TiO 2 NPs on the thermal degradation behavior of the resulting TiO 2 /MAPbI 3 heterogeneous thin films. Figure 7. Presents PL peak emissions of the ( a ) deconvoluted as-prep TiO 2 nanopowder, ( b ) annealed TiO 2 nanopowders, and ( c ) as-prep TiO 2 /MAPbI 3 and annealed heterogeneous thin films at λ ex = 238 nm excitation wavelength. Figure 7. Presents PL peak emissions of the ( a ) deconvoluted as-prep TiO 2 nanopowder, ( b ) annealed TiO 2 nanopowders, and ( c ) as-prep TiO 2 /MAPbI 3 and annealed heterogeneous thin films at λ ex = 238 nm excitation wavelength. Figure 8. Schematic representation of the fabricated solar cell with device architecture ITO/c-TiO 2 /m-TiO 2 /MAPbI 3 /Spiro-MeoTAD/Conductive Ag ink/ITO. Figure 8. Schematic representation of the fabricated solar cell with device architecture ITO/c-TiO 2 /m-TiO 2 /MAPbI 3 /Spiro-MeoTAD/Conductive Ag ink/ITO. Figure 9. IV characterization curves. Table 1. Presents DTGA peak temperatures, TGA degradation steps, and total mass loss from the TiO 2 /MAPbI 3 heterogeneous thin films. Table 1. Presents DTGA peak temperatures, TGA degradation steps, and total mass loss from the TiO 2 /MAPbI 3 heterogeneous thin films. Samples Degradation Steps Total Average Mass (%) Loss H 2 O Evaporation A-R Phase Transition MAI Volatilization DTGA Temperatures (°C) ≥106.2 ≥437.5 ≥512.5 - As-pre TiO 2 /MAPbI 3 1.7% 9.5% 4.5% 15.7% 200/MAPbI 3 0.5% 8.3% 4.4% 13.2% 400/MAPbI 3 0% 6.9% 2.8% 9.7% 800/MAPbI 3 0% 4.5% 1.9% 6.4% 1000/MAPbI 3 0% 3.5% 1.2% 4.7% 1200/MAPbI 3 0% 1.8% 0.4% 2.2% Table 2. Photovoltaic parameters for the PSCs with device architecture ITO/c-TiO 2 /m-TiO 2 /MAPbI 3 /Spiro-MeoTAD/Conductive Ag ink/ITO. Table 2. Photovoltaic parameters for the PSCs with device architecture ITO/c-TiO 2 /m-TiO 2 /MAPbI 3 /Spiro-MeoTAD/Conductive Ag ink/ITO. Device Phase Composition (A/R) V oc (V) J sc (mA·cm −2 ) FF (%) ղ (%) As-pre TiO 2 /MAPbI 3 68/32 0.53 ± 0.02 1.57 ± 0.15 65.7 ± 0.028 1.82 ± 0.55 200/MAPbI 3 65/35 0.54 ± 0.02 1.86 ± 0.13 66.5 ± 0.015 2.22 ± 0.42 400/MAPbI 3 46/54 0.56 ± 0.02 2.31 ± 0.11 66.8 ± 0.023 2.88 ± 0.58 800/MAPbI 3 60/40 0.57 ± 0.02 2.98 ± 0.18 67.4 ± 0.021 3.82 ± 0.72 1000/MAPbI 3 36/64 0.59 ± 0.02 5.02 ± 0.16 68.1 ± 0.025 6.72 ± 0.68 1200/MAPbI 3 34/66 0.58 ± 0.02 3.89 ± 0.17 68.0 ± 0.018 5.11 ± 0.64 Malevu TD, Motaung TE, Motloung SV, Koao LF, Mokoena TP, Mhlongo MR. Investigating the Morphology, Optical, and Thermal Properties of Multiphase-TiO 2/MAPbI 3Heterogeneous Thin-Films for Solar Cell Applications. Condensed Matter. 2022; 7(2):39. https://doi.org/10.3390/condmat7020039 Chicago/Turabian Style Malevu, Thembinkosi D., Tshwafo E. Motaung, Setumo V. Motloung, Lehlohonolo F. Koao, Teboho P. Mokoena, and Motlalepula R. Mhlongo. 2022. "Investigating the Morphology, Optical, and Thermal Properties of Multiphase-TiO 2/MAPbI 3Heterogeneous Thin-Films for Solar Cell Applications" Condensed Matter7, no. 2: 39. https://doi.org/10.3390/condmat7020039 Malevu, T.D.; Motaung, T.E.; Motloung, S.V.; Koao, L.F.; Mokoena, T.P.; Mhlongo, M.R. Investigating the Morphology, Optical, and Thermal Properties of Multiphase-TiO 2/MAPbI 3Heterogeneous Thin-Films for Solar Cell Applications. Condens. Matter 2022, 7, 39. https://doi.org/10.3390/condmat7020039 Malevu TD, Motaung TE, Motloung SV, Koao LF, Mokoena TP, Mhlongo MR. Investigating the Morphology, Optical, and Thermal Properties of Multiphase-TiO 2/MAPbI 3Heterogeneous Thin-Films for Solar Cell Applications. Condensed Matter. 2022; 7(2):39. https://doi.org/10.3390/condmat7020039 Chicago/Turabian Style Malevu, Thembinkosi D., Tshwafo E. Motaung, Setumo V. Motloung, Lehlohonolo F. Koao, Teboho P. Mokoena, and Motlalepula R. Mhlongo. 2022. "Investigating the Morphology, Optical, and Thermal Properties of Multiphase-TiO 2/MAPbI 3Heterogeneous Thin-Films for Solar Cell Applications" Condensed Matter7, no. 2: 39. https://doi.org/10.3390/condmat7020039
https://www.mdpi.com/2410-3896/7/2/39/xml
Basic Bakunin Basic Bakunin Republished from the (British) Anarchist Communist Federation's original pamphlet in 1993 by P.A.C. (Paterson Anarchist Collective) Publications. This electronic version has the extra ACF text added to the PAC version, for more completeness. "The star of revolution will rise high above the streets of Moscow, from a sea of blood and fire, and turn into a lodestar to lead a liberated humanity" -Mikhail Bakunin Preface The aim of this pamphlet is to do nothing more than present an outline of what the author thinks are the key features of Mikhail Bakunin's anarchist ideas. Bakunin was extremely influential in the 19th century socialist movement, yet his ideas for decades have been reviled, distorted or ignored. On reading this pamphlet, it will become apparent that Bakunin has a lot to offer and that his ideas are not at all confused (as some writers would have us think) but make up a full coherent and well argued body of thought. For a detailed but difficult analysis of Bakunin's revolutionary ideas, Richard B. Saltman's book, "The Social and Political Thought of Michael Bakunin" is strongly recommended. Ask your local library to obtain a copy. Class Bakunin saw revolution in terms of the overthrow of one oppressing class by another oppressed class and the destruction of political power as expressed as the state and social hierarchy. According to Bakunin, society is divided into two main classes which are fundamentally opposed to each other. The oppressed class, he variously described as commoners, the people, the masses or the workers, makes up a great majority of the population. It is in 'normal' time not conscious of itself as a class, though it has an 'instinct' for revolt and whilst unorganized, is full of vitality. The numerically much smaller oppressing class, however is conscious of its role and maintains its ascendancy by acting in a purposeful, concerted and united manner. The basic differences between the two classes, Bakunin maintained, rests upon the ownership and control of property, which is disproportionately in the hands of the minority class of capitalists. The masses, on the other hand, have little to call their own beyond their ability to work. Bakunin was astute enough to understand that the differences between the two main classes is not always clear cut. He pointed out that it is not possible to draw a hard line between the two classes, though as in most things, the differences are most apparent at the extremes. Between these extremes of wealth and power there is a hierarchy of social strata which can be assessed according to the degree to which they exploit each other or are exploited themselves. The further away a given group is from the workers, the more likely it is to be part of the exploiting category and the less it suffers from exploitation. Between the two major classes there is a middle class or middle classes which are both exploiting and exploited, depending on their position of social hierarchy. The masses who are the most exploited form, in Bakunin's view, the great revolutionary class which alone can sweep away the present economic system. Unfortunately, the fact of exploitation and its resultant poverty are in themselves no guarantee of revolution. Extreme poverty is, Bakunin thought, likely to lead to resignation if the people can see no possible alternative to the existing order. Perhaps, if driven to great depths of despair, the poor will rise up in revolt. Revolts however tend to be local and therefore, easy to put down. In Bakunin's view, three conditions are necessary to bring about popular revolution. They are: sheer hatred for the conditions in which the masses find themselves the belief the change is a possible alternative Without these three factors being present, plus a united and efficient self organization, no liberatory revolution can possibly succeed. Bakunin had no doubts that revolution must necessarily involve destruction to create the basis of the new society. He stated that, quite simply, revolution means nothing less than war, that is the physical destruction of people and property. Spontaneous revolutions involve, often, the vast destruction of property. Bakunin noted that when circumstances demanded it, the workers will destroy even their own houses, which more often than not, do not belong to them. The negative, destructive urge is absolutely necessary, he argued, to sweep away the past. Destruction is closely linked with construction, since the "more vividly the future is visualized, the more powerful is the force of destruction." Given the close relationship between the concentration of wealth and power in capitalist societies, it is not surprising that Bakunin considered economic questions to be of paramount importance. It is in the context of the struggle between labor and capital that Bakunin gave great significance of strikes by workers. Strikes, he believed, have a number of important functions in the struggle against capitalism. Firstly they are necessary as catalysts to wrench the workers away from their ready acceptance of capitalism, they jolt them out of their condition of resignation. Strikes, as a form of economic and political warfare, require unity to succeed, thus welding the workers together. During strikes, there is a polarization between employers and workers. This makes the latter more receptive to the revolutionary propaganda and destroys the urge to compromise and seek deals. Bakunin thought that as the struggle between labor and capital increases, so will the intensity and number of strikes. The ultimate strike is the general strike. A revolutionary general strike, in which class conscious workers are infused with anarchist ideas will lead, thought Bakunin, to the final explosion which will bring about anarchist society. Bakunin's ideas are revolutionary in a very full sense, being concerned with the destruction of economic exploitation and social/political domination and their replacement by a system of social organization which is in harmony with human nature. Bakunin offered a critique of capitalism, in which authority and economic inequality went hand in hand, and state socialism, (e.g. Marxism) which is one sided in its concentration on economic factors whilst, grossly underestimating the dangers of social authority. State Bakunin based his consistent and unified theory upon three interdependent platforms, namely: human beings are naturally social (and therefore they desire social solidarity) are more or less equal and, want to be free His anarchism is consequently concerned with the problem of creating a society of freedom within the context of an egalitarian system of mutual interaction. The problem with existing societies, he argued, is that they are dominated by states that are necessarily violent, anti-social, and artificial constructs which deny the fulfillment of humanity. Whilst there are, in Bakunin's view, many objectionable features within capitalism, apart from the state, (e.g. the oppression of women, wage slavery), it is the state which nurtures, maintains and protects the oppressive system as a whole. The state is defined as an anti-social machine which controls society for the benefit of an oppressing class or elite. It is essentially an institution based upon violence and is concerned with its maintenance of inequality through political repression. In addition the state relies upon a permanent bureaucracy to help carry out its aims. The bureaucratic element, incidentally, is not simply a tool which it promotes. All states, Bakunin believed, have internal tendencies toward self perpetuation, whether they be capitalist or socialist and are thus to be opposed as obstacles to human freedom. It might be objected that states are not primarily concerned with political repression and violence and indeed that liberal democratic states, in particular, are much interested in social welfare. Bakunin argues that such aspects are only a disguise, and that when threatened, all states reveal their essentially violent natures. In Britain and Northern Ireland this repressive feature of state activity has come increasingly to the fore, when the state has been challenged to any significant degree, it has responded with brutal firmness. And developments within Britain over the last couple decades tend to substantiate another feature of the state which Bakunin drew attention to, their tendency toward over increasing authoritarianism and absolutism. He believed that there were strong pressures in all states whether they are liberal, socialist, capitalist, or whatever, toward military dictatorship but that the rate of such development will vary, however according to factors such as demography, culture and politics. Finally, Bakunin noted that states tend toward warfare against other states. Since there is no internationally accepted moral code between states, then rivalries between them will be expressed in terms of military conflict. "So long as there's government, there will be no peace. There will only be more or less prolonged respites, armistices concluded by the perpetually belligerent states; but as soon as a state feels sufficiently strong to destroy this equilibrium to its advantage, it will never fail to do so." Bourgeois Democracy Political commentators and the media are constantly singing the praises of the system of representative democracy in which every few years or so the electorate is asked to put a cross on a piece of paper to determine who will control them. This system works good insofar as the capitalist system has found a way of gaining legitimacy through the illusion that some how the voters are in charge of running the system. Bakunin's writings on the issue are of representative democracy were made at the time when it barely existed in the world. Yet he could see on the basis of a couple of examples (the United States and Switzerland) that the widening of the franchise does little to improve the lot of the great mass of the population. True, as Bakunin noted, middle class politicians are prepared to humble themselves before the electorate issuing all sorts of promises. But this leveling of candidates before the populace disappears the day after the election, once they are transformed into members of the Parliament. The workers continue to go to work and the bourgeoisie takes up once again the problems of business and political intrigue. Today, in the United States and Western Europe, the predominant political system is that of liberal democracy. In Britain the electoral system is patently unfair in its distribution of parliamentary seats, insofar as some parties with substantial support get negligible representation. However, even where strict proportional representation applies, the Bakuninist critique remains scathing. For the representative system requires that only a small section of the population concern itself directly with legislation and governing (in Britain a majority out of 650 MP's (Members of Parliament)). Bakunin's objections to representative democracy rests basically on the fact that it is an expression of the inequality of power which exists in society. Despite constitutions guaranteeing the rights of citizens and equality before the law, the reality is that the capitalist class is in permanent control. So long as the great mass of the population has to sell its labor power in order to survive, there can not be democratic government. So long as people are economically exploited by capitalism and there are gross inequalities of wealth, there can not be real democracy. As Bakunin made clear, economic facts are much stronger than political rights. So long as there is economic privilege there will be political domination by the rich over the poor. The result of this relationship is that representatives of capitalism (bourgeois democracy) "posses in fact, if not by right, the exclusive privilege of governing." A common fiction that is expounded in liberal democracies is that the people rule. However the reality is that minorities necessarily do the governing. A privileged few who have access to wealth, education and leisure time, clearly are better equipped to govern than ordinary working people, who generally have little free time and only a basic education. "determined aristocrats, bold or timid worshipers of the principle of authority who will also become exploiters and oppressors." The point that Bakunin makes time and time again in his writings is that no one can govern for the people in their interests. Only personal and direct control over our lives will ensure that justice and freedom will prevail. To abdicate direct control is to deny freedom. To grant political sovereignty to others, whether under the mantle of democracy, republicanism, the people's state, or whatever, is to give others control and therefore domination over our lives. It might be thought that the referendum, in which people directly make laws, would be an advance upon the idea of representative democracy. This is not the case according to Bakunin, for a variety of reasons. Firstly, the people are not in a position to make decisions on the basis of full knowledge of all the issues involved. Also, laws may be a complex, abstract, and specialized nature and that in order to vote for them in a serious way, the people need to be fully educated and have available the time and facilities to reflect upon and discuss the implications involved. The reality of referenda is that they are used by full-time politicians to gain legitimacy for essentially bourgeois issues. It is no coincidence that Switzerland, which has used the referendum frequently, remains one of the most conservative countries in Europe. With referenda, the people are guided by politicians, who set the terms of the debate. Thus despite popular input, the people still remain under bourgeois control. Finally, Bakunin on the whole concept of the possibility of the democratic state: For him the democratic state is a contradiction in terms since the state is essentially about force, authority and domination and is necessarily based upon an inequality of wealth and power. Democracy, in the sense of self rule for all, means that no one is ruled. If no one rules, there can be no state. If there is a state, there can be no self rule. Marx Bakunin's opposition to Marxism involves several separate but related criticisms. Though he thought Marx was a sincere revolutionary, Bakunin believed that the application of the Marxist system would necessarily lead to the replacement of one repression (capitalist) by another (state socialist). Firstly, Bakunin opposed what he considered to be the economic determinist element in Marx's thought, most simply stated that "Being determines consciousness." Put in another way, Bakunin was against the idea that the whole range of 'super structural' factors of society, its laws, moralities, science, religion, etc. were "but the necessary after effects of the development of economic facts." Rather than history or science being primarily determined by economic factors (e.g. the 'mode of production'), Bakunin allowed much more for the active intervention of human beings in the realization of their destiny. More fundamental was Bakunin's opposition to the Marxist idea of dictatorship of the proletariat which was, in effect, a transitional state on the way to stateless communism. Marx and Engles, in the Communist Manifesto of 1848, had written of the need for labor armies under state supervision, the backwardness of the rural workers, the need for centralized and directed economy, and for wide spread nationalization. Later, Marx also made clear that a workers' government could come into being through universal franchise. Bakunin questioned each of these propositions. The state, whatever its basis, whether it be proletarian or bourgeois, inevitably contains several objectionable features. States are based upon coercion and domination. This domination would, Bakunin stated, very soon cease to be that of the proletariat over its enemies but would become a state over the proletariat. This would arise, Bakunin believed, because of the impossibility of a whole class, numbering millions of people, governing on its own behalf. Necessarily, the workers would have to wield power by proxy by entrusting the tasks of government to a small group of politicians. Once the role of government was taken out of the hands of the masses, a new class of experts, scientists and professional politicians would arise. This new elite would, Bakunin believed, be far more secure in its domination over the workers by means of the mystification and legitimacy granted by the claim to acting in accordance with scientific laws (a major claim by Marxists). Furthermore, given that the new state could masquerade as the true expression of the people's will. The institutionalizing of political power gives rise to a new group of governors with the same self seeking interests and the same cover-ups of its dubious dealings. Another problem posed by the statist system, that of centralized statist government would, argued Bakunin, further strengthen the process of domination. The state as owner, organizer, director, financier, and distributor of labor and economy would necessarily have to act in an authoritarian manner in its operations. As can be seen by the Soviet system, a command economy must act with decision flowing from top to bottom; it cannot meet the complex and various needs of individuals and, in the final analysis, is a hopeless, inefficient giant. Marx believed that centralism, from whatever quarter, was a move toward the final, statist solution of revolution. Bakunin, in contrast opposed centralism by federalism. Bakunin's predictions as to the operation of Marxist states has been borne out of reality. The Bolsheviks seized power in 1917, talked incessantly of proletarian dictatorship and soviet power, yet inevitably, with or without wanting to, created a vast bureaucratic police state. Unions Most of the left in Britain view the present structures of trade unions in a positive light. This is true for members of the Labor Party, both left and right, the Communist Party, the Militant Tendency and many other Marxist organizations. These bodies wish to capture or retain control of the unions, pretty much as they stand, in order to use them for their own purposes. As a result, there are frequently bitter conflicts and maneuverings within the unions for control. This trend is most apparent in the C.P.S.A. where a vicious anti-communist right wing group alternates with the Militant Tendency and its supporters for control of the union executive and full time posts. The major exception to this is the Socialist Workers Party which advocates rank and file organization, so long as the S.W.P. can control it. Bakunin laid the foundations of the anarchist approach to union organization and the general tendency of non-anarchist unions to decay into personal fiefdoms and bureaucracy over a century ago. Arguing in the context of union organization within the International Working Mens Association, he gave examples of how unions can be stolen from the membership whose will they are supposed to be an expression of. He identified several interrelated features which lead to the usurpation of power by union leaders. Firstly, he indicated a psychological factor which plays a key part. Honest, hardworking, intelligent and well meaning militants win through hard work the respect and admiration of their fellow members and are elected to union office. They display self sacrifice, initiative and ability. Unfortunately, once in positions of leadership, these people soon imagine themselves to be indispensable and their focus of attention centers more and more on the machinations within the various union committees. Given the existence of union bureaucracies and secret debating chambers in which leaders decide union actions and policies, a 'governmental aristocracy' arises within the union structures, no matter how democratic those structures may formally be. With the growing authority of the union committees etc., the workers become indifferent to union affairs, with the exception Bakunin asserts, of issues which directly affect them e.g. dues payment, strikes etc. Unions have always had great problems in getting subscriptions from alienated memberships, a solution which has been found in the 'check off' system by which unions and employers collaborate to remove the required sum at source, i.e. from the pay packet. Where workers do not directly control their union and delegate authority to committees and full-time agents, several things happen. Firstly, so long as union subscriptions are not too high, and back dues are not pressed too hard for, the substituting bodies can act with virtual impunity. This is good for the committees but brings almost to an end the democratic life of the union. Power gravitates increasingly to the committees and these bodies, like all governments substitute their will for that of the membership. This in turn allows expression for personal intrigues, vanity, ambition and self-interest. Many intra-union battles, which are ostensibly fought on ideological grounds, are in fact merely struggles for control by ambitious self seekers who have chosen the union for their career structure. This careerism occasionally surfaces in battles between rival leftists, for example where no political reasons for conflict exist. In the past the Communist Party offered a union career route within certain unions and such conflicts constantly arose. Presumably, within the Militant Tendency, which also wishes to capture unions, the same problem exists. Within the various union committees, which are arranged on a hierarchical basis (mirroring capitalism), one or two individuals come to dominate on the basis of superior intelligence or aggressiveness. Ultimately, the unions become dominated by bosses who hold great power in their organizations, despite the safeguards of democratic procedures and constitutions. Over the last few decades, many such union bosses have become national figures, especially in periods of Labor government. Bakunin was aware that such union degeneration was inevitable but only arises in the absence of rank and file control, lack of opposition to undemocratic trends and the accession to union power to those who allow themselves to be corrupted. Those individuals who genuinely wish to safeguard their personal integrity should, Bakunin argued, not stay in office too long and should encourage strong rank and file opposition. Union militants have a duty to remain faithful to their revolutionary ideals. Personal integrity, however, is an insufficient safeguard. Other, institutional and organizational factors must also be brought into play. These include regular reporting to the proposals made by the officials and how they voted, in other words frequent and direct accountability. Secondly, such union delegates must draw their mandates from the membership being subject to rank and file instructions. Thirdly, Bakunin suggests the instant recall of unsatisfactory delegates. Finally, and most importantly, he urged the calling of mass meetings and other expressions of grass roots activity to circumvent those leaders who acted in undemocratic ways. Mass meetings inspire passive members to action, creating a camaraderie which would tend to repudiate the so called leaders. (Electronic Ed- From this, one can conclude that Bakunin was a major inspiration for the anarcho-syndicalist movement.) Revolutionary Organization Above all else, Bakunin the revolutionary, believed in the necessity of collective action to achieve anarchy. After his death there was a strong tendency within the anarchist movement towards the abandonment of organization in favor of small group and individual activity. This development, which culminated in individual acts of terror in the late nineteenth century France, isolating anarchism from the very source of the revolution, namely the workers. Bakunin, being consistent with other aspects of his thought, saw organization not in terms of a centralized and disciplined army (though he thought self discipline was vital), but as the result of decentralized federalism in which revolutionaries could channel their energies through mutual agreement within a collective. It is necessary, Bakunin argued, to have a coordinated revolutionary movement for a number of reasons. Firstly, is anarchists acted alone, without direction they would inevitably end up moving in different directions and would, as a result, tend to neutralize each other. Organization is not necessary for its own sake, but is necessary to maximize strength of the revolutionary classes, in the face of the great resources commanded by the capitalist state. However, from Bakunin's standpoint, it was the spontaneous revolt against authority by the people which is of the greatest importance. The nature of purely spontaneous uprisings is that they are uneven and vary in intensity from time to time and place to place. The anarchist revolutionary organization must not attempt to take over and lead the uprising but has the responsibility of clarifying goals, putting forward revolutionary propaganda, and working out ideas in correspondence with the revolutionary instincts of the masses. To go beyond this would undermine the whole self-liberatory purpose of the revolution. Putchism has no place in Bakunin's thought. Bakunin then, saw revolutionary organization in terms of offering assistance to the revolution, not as a substitute. It is in this context that we should interpret Bakunin's call for a "secret revolutionary vanguard" and "invisible dictatorship" of that vanguard. The vanguard it should be said, has nothing in common with that of the Leninist model which seeks actual, direct leadership over the working class. Bakunin was strongly opposed to such approaches and informed his followers that The vanguard was, however, to influence the revolutionary movement on an informal basis, relying on the talents of it's members to achieve results. Bakunin thought that it was the institutionalization of authority, not natural inequalities, that posed a threat to the revolution. The vanguard would act as a catalyst to the working classes' own revolutionary activity and was expected to fully immerse itself in the movement. Bakunin's vanguard then, was concerned with education and propaganda, and unlike the Leninist vanguard party, was not to be a body separate from the class, but an active agent within it. The other major task of the Bakuninist organization was that it would act as the watchdog for the working class. Then, as now, authoritarian groupings posed as leaders of the revolution and supplied their own members as "governments in waiting." The anarchist vanguard has to expose such movements in order that the revolution should not replace one representative state by another 'revolutionary' one. After the initial victory, the political revolutionaries, those advocates of so-called workers' governments and the dictatorship of the proletariat, would according to Bakunin try "to squelch the popular passions. They appeal for order , for trust in, for submission to those who, in the course and the name of the revolution, seized and legalized their own dictatorial powers; this is how such political revolutionaries reconstitute the state. We on the other hand, must awaken and foment all the dynamic passions of the people." Anarchy Throughout Bakunin's criticisms of capitalism and state socialism he constantly argues for freedom. It is not surprising, then, to find that in his sketches of future anarchist society that the principle of freedom takes precedence. In a number of revolutionary programs he outlined which he considered to be the essential features of societies which would promote the maximum possible individual and collective freedom. The societies envisioned in Bakunin's programs are not Utopias, the sense of being detailed fictional communities, free of troubles, but rather suggest the basic minimum skeletal structures which would guarantee freedom. The character of future anarchist societies will vary, said Bakunin depending on a whole range of historical, cultural, economic and geographical factors. The basic problem was to lay down the minimum necessary conditions which would bring about a society based upon justice and social welfare for all and would also generate freedom. The negative, that is, destructive features of the programs are all concerned with the abolition of those institutions which lead to domination and exploitation. The state, including the established church, the judiciary, state banks and bureaucracy, the armed forces and the police are all to be swept away. Also, all ranks, privileges, classes and the monarchy are to be abolished. The positive, constructive features of the new society all interlink to promote freedom and justice. For a society to be free, Bakunin argued, it is not sufficient to simply impose equality. No, freedom can only be achieved and maintained through the full participation in society of a highly educated and healthy population, free from social and economic worries. Such an enlightened population, can then be truly free and able to act rationally on the basis of a popularly controlled science and a thorough knowledge of the issues involved. Bakunin advocated complete freedom of movement, opinion, morality where people would not be accountable to anyone for their beliefs and acts. This must be, he argued, complete and unlimited freedom of speech, press and assembly. Freedom, he believed, must be defended by freedom, for to "advocate the restriction of freedom on the pretext that it is being defended is a dangerous delusion." A truly free and enlightened society, Bakunin said, would adequately preserve liberty. An ordered society, he thought, stems not from suppression of ideas, which only breeds opposition and factionalism, but from the fullest freedom for all. This is not to say that Bakunin did not think that a society has the right to protect itself. He firmly believed that freedom was to be found within society, not through its destruction. Those people who acted in ways that lessen freedom for others have no place; These include all parasites who live off the labor of others. Work, the contribution of one's labor for the creation of wealth, forms the basis of political rights in the proposed anarchist society. Those who live by exploiting others do not deserve political rights. Others, who steal, violate voluntary agreements within and by society, inflict bodily harm etc. can expect to be punished by the laws which have been created by that society. The condemned criminal, on the other hand, can escape punishment by society by removing himself/herself from society and the benefits it confers. Society can also expel the criminal if it so wishes. Basically thought, Bakunin set great store on the power of enlightened public opinion to minimize anti-social activity. Bakunin proposed the equalization of wealth, though natural inequalities which are reflected in different levels of skill, energy and thrift, should he argued be tolerated. The purpose of equality is to allow individuals to find full expression of their humanity within society. Bakunin was strongly opposed to the idea of hired labor which if introduced into an anarchist society, would lead to the reintroduction of inequality and wage slavery. He proposed instead collective effort because it would, he thought, tend to be more efficient. However, so long as individuals did not employ others, he had no objection to them working alone. Through the creation of associations of labor which could coordinate worker's activities, Bakunin proposed the setting up of an industrial assembly in order to harmonize production with the demand for products. Such an assembly would be necessary in the absence of the market. Supplied with statistical information from the various voluntary organization who would be federated, production could be specialized on an international basis so that those countries with inbuilt economic advantages would produce most efficiently for the general good. Then, according to Bakunin, waste, economic crisis and stagnation "will no longer plague mankind; the emancipation of human labor will regenerate the world." Turning to the question of the political organization of society, Bakunin stressed that they should all be built in such a way as to achieve order through the realization of freedom on the basis of the federation of voluntary organizations. In all such political bodies power is to flow "from the base to the summit" and from "the circumference to the center/" In other words, such organizations should be the expressions of individual and group opinions, not directing centers which control people. On the basis of federalism, Bakunin proposed a multi-tier system of responsibility for decision making which would be binding on all participants, so long as they supported the system. Those individuals, groups or political institutions which made up the total structure would have the right to secede. Each participating unit would have an absolute right to self-determination, to associate with the larger bodies, or not. Starting at the local level, Bakunin suggested as the basic political unit, the completely autonomous commune. The commune, on the basis of universal suffrage, would elect all of its functionaries, law makers, judges, and administrators of communal property. The commune would decide its own affairs but, if voluntarily federated to the next tier of administration, the provincial assembly, its constitution must conform to the provincial assembly. Similarly, the constitution of the province must be accepted by the participating communes. The provincial assembly would define the rights and obligations existing between communes and pass laws affecting the province as a whole. The composition of the provincial assembly would be decided on the basis of universal suffrage. Further levels of political organization would be the national body, and, ultimately, the international assembly. As regards international organization, Bakunin proposed that there should be no permanent armed forces, preferring instead, the creation of local citizens' defense militias. Disputes between nations and their provinces would be settled by an international assembly. This assembly, if required, could wage war against outside aggressors but should a member nation of the international federation attack another member, then it faces expulsion and the opposition of the federation as a whole. Thus, from root to branch, Bakunin's outline for anarchy is based upon the free federation of participants in order to maximize individual and collective well being. Bakunin's Relevance Today Throughout most of this pamphlet Bakunin has been allowed to speak for himself and any views by the writer of the pamphlet are obvious. In this final section it might be valuable to make an assessment of Bakunin's ideas and actions. With the dominance of Marxism in the world labor and revolutionary movements in the twentieth century, it became the norm to dismiss Bakunin as muddle-headed or irrelevant. However, during his lifetime he was a major figure who gained much serious support. Marx was so pressured by Bakunin and his supporters that he had to destroy the First International by dispatching it to New York. In order that it should not succumb to Anarchism, Marx killed it off through a bureaucratic maneuver. Now that Marxism has been seriously weakened following the collapse of the USSR and the ever increasingly obvious corruption in China, Bakunin's ideas and revolutionary Anarchism have new possibilities. If authoritarian, state socialism has proved to be a child devouring monster, then libertarian communist ideas once again offer a credible alternative. The enduring qualities of Bakunin and his successors are many, but serious commitment to the revolutionary overthrow of capitalism and the state must rank high. Bakunin was much more of a doer than a writer, he threw himself into actual insurrections, much to the trepidation of European heads of state. This militant tradition was continued by Malatesta, Makhno, Durruti, and many other anonymous militants. Those so-called anarchists who adopt a gradualist approach are an insult to Anarchism. Either we are revolutionaries or we degenerate into ineffective passivism. Bakunin forecast the dangers of statist socialism. His predictions of a militarized, enslaved society dominated by a Marxist ruling class came to pass in a way that even Bakunin could not have fully envisaged. Lenin, Trotsky and Stalin outstripped even the Tsars in their arrogance and brutality. And, after decades of reformist socialism which have frequently formed governments, Bakunin's evaluations have been proved correct. In Britain we have the ultimate insult to working people in the form of "socialist Lords". For services to capitalism, Labor MP's are ultimately granted promotion to the aristocracy. Bakunin fought for a society based upon justice, equality and freedom. Unlike political leaders of the left he had great faith in the spontaneous, creative and revolutionary potential of working people. His beliefs and actions reflect this approach. So, revolutionaries can learn much of value from his federalism, his militancy and his contempt for the state, which, in the twentieth century, has assumed gigantic and dangerous proportions, Bakunin has much to teach us but we too must develop our ideas in the face of new challenges and opportunities. We must retain the revolutionary core of his thought yet move forward. Such is the legacy of Bakunin. With this in mind, the Anarchist Communist Federation is developing a revolutionary anarchist doctrine, which whilst being ultimately based on Bakunin's ideas, goes much further to suit the demands of present-day capitalism. Ecological issues, questions of imperialist domination of the world, the massive oppression of women, the automation of industry, computerized technology etc. are all issues that have to be tackled. We welcome the challenge! FURTHER READING There are two main compilations of Bakunin's works which are quite readily available through public libraries. They are "Bakunin on Anarchy" edited by Sam Dolgoff and "The Political Philosophy of Bakunin" edited by G.P. Maximoff. Also worth looking at, if you can get hold of them are "The Basic Bakunin - Writings 1869-1871" edited by Robert M. Cutler and "Mikhail Bakunin - From Out of the Dustbin" , edited by the same person. For an understanding of the full profundity of Bakunin's ideas, there is nothing to match "The Social and Political Thought of Michael Bakunin" by Richard B Saltman. This American publication should be available through your local library. Bakunin's works currently available: "God and the State" "Marxism, Freedom and the State" (edited by K.J. Kenafik) "The Paris Commune and the Idea of the State" "Statism and Anarchy" (heavy going) ed. Marshall Shatz.
https://www.j12.org/spunk/library/writers/bakunin/sp001862.html
Coordination and Joint Action Accessibility for the Blind: The Necessity for Coordination and Joint Action Technology for the blind has been the hope and the frustration of blind people for as long as technology has existed. Even Braille, which was invented more than a hundred and fifty years ago and which has provided literacy to many blind people, has often been more of a promise of hope than a reality of achievement. This is so because many blind people never had competent Braille instruction available to them, and sometimes administrators of programs for the blind failed to believe in their own clients and ignored the skills and techniques that are used by the blind. In the 1960's the portable tape recorder became generally available, and a number of people said that this new technology would (at long last) make the world of literary works available to the blind for the first time. Braille (it was said), though effective for many, was difficult to learn, was bulky, and would forever be in short supply. The tape recorder--especially the cassette recorder--would open literacy for the blind. In the 1970's a number of new products for the blind were being developed--many of which used the computer as the framework for managing information. As the '70's dissolved into the '80's, specialized technological adaptations of the computer proliferated. The Reading Machine developed by Dr. Kurzweil in the mid 1970's became less expensive and more efficient. Braille printers increased in speed and accuracy. The Port-a-Braille was invented by Dr. Cranmer, and this invention was modified, enhanced, and streamlined by Deane Blazie to become the Braille 'n Speak, which has altered learning methods for blind students and note-taking for blind adults. In the 1980's, with the advent of access technology using the disk operating system, obtaining information from the computer began to be manageable. Then the graphical user interface became a part of the computer scene, and access by the blind to computer information deteriorated. There were those who said that making information on the computer screen into speech or Braille could never happen. Some blind people met this announcement with despair, and others greeted it with anger or a determination to make things different. A number of sighted technicians told the blind that presenting information visually was fundamentally different from presenting it in audio form or in Braille. They said that access to information from a computer would always be more limited and circumscribed for the blind than the same access for the sighted. What had been available to the blind in the DOS environment could not be replicated with the graphical user interface. Blind people responded by telling the manufacturers that our lives are being crippled, that our jobs are being taken, that we are being prevented from participating in the eerie world of the Internet, and that with the increasing use of computers in the schools even our opportunities for education are being diminished. The systematic exclusion of the blind from the world of technology could not be permitted to continue. We let it be known that we would fight for the right to be a part of the technological world. We would urge our cause on the public platforms, in the governmental offices of regulatory agencies, in the halls of Congress, in the academic arenas, and in the public mind. If necessary, we would take to the streets and make a public demonstration of the urgency that faced us in the information age. We would never be satisfied until the blind had the same opportunities for participation that were available to everybody else. In the midst of the effort to bring public attention to the changing environment in the technological world, we asked the experts what had happened. What was there about the graphical user interface that made the information presented through it so difficult to interpret? It seemed particularly ironic that, as computers became more powerful, the blind had less access to the information that was in them. What appeared to have happened was that the increasing power of the computers offered more opportunities for visual presentation, and these became so numerous that interpretation for an alternate presentation in speech and Braille was difficult. In the DOS environment the number of windows available was usually one, the screen of the computer. The number of characters used for presenting information was limited to two hundred and fifty-five. With the graphical user interface, the number of windows for presentation increased to whatever the eye could interpret, and the character set became essentially unlimited. In the DOS medium most things were presented using text. With Windows, text and other representations were used together. The DOS computer manipulated pages of print. Windows computers manipulated information that looks much more like what an individual might find along a street. There are storefront windows with displays, streetlights, signs on buildings or lampposts, and other images such as a raised hand in red light to indicate don't walk. Interpreting the jumble of text, icons, decorations, and other symbols requires a level of sophisticated knowledge unlike anything previously presented in the computer environment. The job of transforming this mixture into intelligible speech or readable Braille is daunting, but it must be done. What began with the computer has in many respects occurred with other machines. Many devices have visual display panels and a set of operating symbols that demand interaction with them. Microwaves, bread machines, televisions, stereos, and a host of other devices have interactive visual displays. In an increasing number of cases even the knobs and buttons have disappeared. When I was a boy at the school for the blind, operating a radio was easy. One knob turned it on and set the volume. The other knob selected the frequency. Occasionally, radios like my old friend at the school for the blind can still be found. However, radios now often have arrow buttons and a mode selector. It is essential to see the screen to get the frequency you want, and independent operation for the blind is completely impractical. The frustrations in achieving access to technology for the blind are well known to us all. We have tried individually to solve them, and sometimes we have had substantial success in doing so. However, we have frequently discovered that the talent and power we possess individually are insufficient to address the universe of needs. To meet the objectives of full access to technology for the blind, we need coordinated action. I suggest that we establish a board to review technology for the blind. We might call it the National Information Access Board for the Blind. This board would pool resources from its participating members, and it would establish standards to determine whether products are accessible to the blind. Such a board would encourage manufacturers to submit products and programs for technology-access review. It would provide feedback regarding the characteristics essential for accessibility to the blind. Organizations of consumers should be a central part of such a review board because the users of the products are those who will be most dramatically affected. However, the manufacturers will also have much to provide in judging products produced by others. The standards for accessibility should provide that no organization is permitted to determine whether its product meets the guidelines. Each organization that wants to be a part of the board must commit resources to make such an enterprise practical, and all organizations participating will have an equal voice in decision-making. Each organization should be prepared to contribute both funding to meet the ongoing expenses of the board and personnel who are technically competent. Each participating organization should contribute $25,000 a year for the initial costs of operating the board. If this sum is insufficient to meet the on-going expenses, each should share the expense of the shortfall. The National Federation of the Blind will pledge to put $25,000 aside for this purpose, and we urge others to join us in creating the National Information Access Board for the Blind. Can a particular device be operated by a blind person? Can it be used by a blind person to get data from the Internet? Is it effective in assisting a blind person to retrieve information from a device that would ordinarily provide it only visually? These are fundamental questions to be answered by the board. Everybody is invited to be a part of it. Today many of the answers would necessarily be "no." We must combine our energies to open the doors for the blind to enter the information age. When the answers are "yes," our joint efforts to promote accessibility will have been a success, and I think we should do it.
https://nfb.org/images/nfb/publications/bm/bm00/bm0001/bm000119.htm
Rotman v. Progressive Ins. Co., Case No. 5:12–cv–67. - Federal Cases - Case Law - VLEX 893797128 0: [object Object]. 1: [object Object]. 2: [object Object]. 3: [object Object]. 4: [object Object]. 5: [object Object] Rotman v. Progressive Ins. Co., Case No. 5:12–cv–67. Court United States District Courts. 2nd Circuit. District of Vermont Writing for the Court CHRISTINA REISS Citation 955 F.Supp.2d 272 Parties Lisa ROTMAN, Plaintiff, v. PROGRESSIVE INSURANCE COMPANY and The Concord Group, Defendants. Docket Number Case No. 5:12–cv–67. Decision Date 28 June 2013 955 F.Supp.2d 272 Lisa ROTMAN, Plaintiff, v. PROGRESSIVE INSURANCE COMPANY and The Concord Group, Defendants. Case No. 5:12–cv–67. United States District Court, D. Vermont. June 28, 2013. [955 F.Supp.2d 275] Susan J. Flynn, Clark Werner & Flynn, P.C., Burlington, VT, Barbara R. Blackman, Lynn, Lynn & Blackman, P.C., for Defendants. OPINION AND ORDER GRANTING IN PART DEFENDANTS' MOTION TO EXCLUDE AND DENYING DEFENDANTS' MOTION FOR SUMMARY JUDGMENT (Doc. 31, 35) CHRISTINA REISS, Chief Judge. Plaintiff Lisa Rotman brings this insurance coverage action seeking compensation under the uninsured motorist insurance policy she holds with Defendants Progressive Insurance Company (“Progressive”), as well as the excess coverage uninsured motorist insurance policy she holds with The Concord Group (“Concord”) (collectively “Defendants”). Plaintiff alleges she was injured in a motorcycle crash in Sheldon, Vermont, after exiting the roadway to avoid oncoming vehicles which she claims were “crowding” the centerline and travelling at an excessive rate of speed in the opposite lane of travel. Presently before the court are Defendants' motions to exclude the testimony of Plaintiff's expert witness, Robert Duhaime, and for summary judgment.(Docs. 31 & 35.) Defendants contend that Mr. Duhaime's opinion is unreliable and is based entirely on the observations of an interested witness. Defendants further contend that without Mr. Duhaime's opinion, Plaintiff cannot survive summary judgment. Plaintiff opposes the motions and requested an evidentiary hearing to address the Daubert issue raised by Defendants. An evidentiary hearing was held on April 11, 2013. Plaintiff is represented by Brooks G. McArthur, Esq. and David J. Williams, Esq. Defendants are represented by Susan J. Flynn, Esq. and Barbara R. Blackman, Esq. I. Factual Background. A. Plaintiff's Supplemental Statement of Undisputed Facts. Plaintiff filed a supplemental statement of undisputed material facts in addition to her response to Defendants' statement of undisputed facts.(Doc. 36–1.) Defendants have neither moved to strike Plaintiff's additional facts nor responded to [955 F.Supp.2d 276] them in any manner. Accordingly, it is difficult to discern whether Plaintiff's additional facts are in fact disputed. In Schroeder v. Makita Corp., 2006 WL 335680 (D.Vt. Feb. 13, 2006) (Sessions, C.J.), this court ruled that the Local Rules do not provide an opportunity for the nonmoving party to file a statement of undisputed facts at the summary judgment stage. Id.at *3. The court explained: Local Rule 7.1(c)(2) afforded Schroeder [the party opposing summary judgment] the opportunity to bring relevant disputed factual matters to the Court's attention, and he took full advantage of this opportunity by filing a 33–page response to Makita's statement of undisputed facts. The Local Rules make no provision for the second document filed by Schroeder. Furthermore, because a party's ability to withstand summary judgment depends on the existence of disputed facts, not undisputed ones, there is no need for Schroeder to establish undisputed facts at this stage of the litigation. Accordingly, the Court will strike Schroeder's Statement of Undisputed Facts, and Makita is under no obligation to respond to it. The Court will not consider the document in its disposition of the remaining motions. Id.at *4. The court adopted this same approach in Post v. Killington Ltd., 2010 WL 3323659, at *1 n. 1 (D.Vt. May 17, 2010), as well as in Boule v. Pike Industries, Inc., 2013 WL 711937, at *1–2 (D.Vt. Feb. 27, 2013), although in both instances it considered any additional facts that were both integral to the parties' arguments and undisputed. Local Rule 56(b) (effective June 29, 2012) provides that “a party opposing summary judgment ... must provide a separate, concise statement of disputed material facts.” All material facts in the movant's statement of undisputed facts are deemed to be admitted unless controverted by the opposing party's statement. The rule thus does not authorize the filing of a statement of additional undisputed facts by the non-moving party. In this case, the court will follow Schroeder, Post, and Boule, and will disregard Plaintiff's additional facts unless it is clear from the parties' briefing that those facts are both material and undisputed. B. Undisputed Facts. On August 20, 2011, Plaintiff and Daren Hall, the son of Plaintiff's domestic partner, 1 were riding motorcycles southbound on Main Street in Sheldon, Vermont. Mr. Hall was traveling in the left-hand tire groove 2 of the southbound lane, closest to the centerline, while Plaintiff was riding behind him, staggered, in the right-hand tire groove furthest away from the centerline. While travelling southbound, Mr. Hall and Plaintiff approached a curve in the roadway. 3 Mr. Hall navigated the [955 F.Supp.2d 277] curve first and, after doing so, observed at least one oncoming vehicle driving northbound in the opposite lane of travel. He noted that the oncoming vehicle or vehicles appeared to be “crowding” the centerline without crossing into his lane of travel. He estimated that the vehicle or vehicles were “a foot if not closer” to the centerline.(Doc. 33–2 at 10–11.) Mr. Hall did not discern the color, make, model, or occupants of the vehicle or vehicles, however, he observed that the vehicles were not sports utility vehicles or vans. After the oncoming vehicle or vehicles passed him, Mr. Hall looked in his rearview mirror and observed that Plaintiff's motorcycle had left the roadway. He did not witness the accident and cannot testify as to what caused it. The Vermont State Police (“VSP”) responded to the accident scene. VSP Trooper Cory Lozier completed an accident report and created a not-to-scale diagram indicating Plaintiff's crash location on the western shoulder of the road. Trooper Lozier did not take photographs or otherwise memorialize the scene. Based on his observations, Trooper Lozier estimated that Plaintiff's motorcycle travelled approximately seventy-five yards after exiting the road and before crashing. Trooper Lozier did not observe skid marks on the road or make an estimate as to the speed of the vehicles although he indicated that Plaintiff's motorcycle appeared to be travelling at a low rate of speed at the time of the crash. Plaintiff has no independent recall of the events leading up to and culminating in her injuries. Plaintiff disclosed Robert Duhaime, a retired VSP Detective Sergeant, as an expert in accident reconstruction. Mr. Duhaime prepared a two-page “Expert Accident Reconstruction Opinion” (the “Expert Report”) dated January 19, 2012.(Doc. 33–1.) In his Expert Report, Mr. Duhaime initially opined that “this motorcycle accident was caused by two unidentified speeding vehicles traveling left of center when meeting [Plaintiff's] motorcycle causing [her] to go off the road to avoid a collision.” Id.at 1–2. He noted that there was damage to the northbound lane of travel and he “found the timing sequence of events as experienced by the lead motorcyclist [Mr. Hall] to be correct.” Id.at 2. He opined that Plaintiff: was confronted with a sudden dangerous situation of being in a left hand curve on the motorcycle and meeting vehicles traveling at a high rate of speed and the lead vehicle being partially on [Plaintiff's] side of the road causing [Plaintiff's motorcycle] to drive away from the danger of a head on collision, straighten the motorcycle, thus reducing the turning radius resulting in the motorcycle going off the road resulting in the accident and subsequent injuries. (Doc. 33–1 at 2.) Mr. Duhaime bases his opinions on “my experience, training and education together with my inspection and evaluation of the accident scene, my review of the police reports and interviews with witnesses ... including [Mr.] Hall, the lead motorcyclist.” Id.at 1. Although Plaintiff agreed that Mr. Duhaime's Expert Report was a “complete and accurate” disclosure of his expert opinion, it was later revealed that Mr. Duhaime was under the misimpression that the oncoming vehicle or vehicles had crossed into Plaintiffs line of travel while passing Mr. Hall. When this misunderstanding [955 F.Supp.2d 278] was corrected, Mr. Duhaime's opinion remained unchanged. Mr. Duhaime testified that determining speed, distance, and time are three critical variables in accident reconstruction. In this case, he was unable to make exact measurements or establish timing sequences because the investigating VSP troopers failed to document or otherwise memorialize the accident scene. He therefore did not measure any distances at the scene so as to correlate them with the supposed positions of the relevant vehicles traveling at various speeds. Mr. Duhaime has not examined Plaintiff's motorcycle or any photographs of it. He concedes that Plaintiff “technically” violated 23 V.S.A. § 1081 4 at the time of the accident by driving off the roadway. Mr. Duhaime's conclusions regarding the specific facts of the incident are derived from Mr. Hall. As Mr. Duhaime explained, “[w]e don't know what happened at that accident other than what that witness [Mr. Hall] saw when he was riding and facing those cars”(Doc. 32 at ¶ 19) and “I don't know what startled [Plaintiff], but something startled her about those vehicles, and she lost control.”(Doc. 33–6 at 48.) Plaintiff is covered for bodily injury damages caused by an “uninsured motorist” by Progressive, with excess coverage from Concord. Plaintiff's insurance policy with Progressive provides coverage as follows: INSURING AGREEMENT—UNINSURED/UNDERINSURED MOTORIST BODILY INJURY COVERAGE If you pay the premium for this coverage, we will pay for damages that an insured person is legally entitled to recover from the owner or operator of an uninsured motor vehicle or underinsured motor vehicle... 24 practice notes
https://case-law.vlex.com/vid/rotman-v-progressive-ins-893797128
A thromboxane synthetase antagonist ameliorates progressive renal disease of Dahl-S rats | Request PDF Request PDF | A thromboxane synthetase antagonist ameliorates progressive renal disease of Dahl-S rats | Recent studies have suggested a role for thromboxane in the progression of renal disease. The current study evaluated the role of this arachidonic... | Find, read and cite all the research you need on ResearchGate A thromboxane synthetase antagonist ameliorates progressive renal disease of Dahl-S rats February 1988 Kidney International 33(1):77-83 DOI: 10.1038/ki.1988.12 Authors: Abstract Recent studies have suggested a role for thromboxane in the progression of renal disease. The current study evaluated the role of this arachidonic acid metabolite in a model of renal disease which bears many biologic similarities to that in the kidneys of patients with chronic progressive renal failure. The model is that induced by ferritin-anti-ferritin immune complex nephritis in Dahl-salt sensitive rats rendered hypertensive by a high salt intake. Rats with this model of renal disease were chronically given a thromboxane synthetase antagonist OKY-046 or a placebo treatment from 16 to 29 weeks of age. Sequential observations of serum creatinine and 24-hour urinary protein excretion showed an ameliorating effect of OKY-046 on these renal parameters. Histologic examination of the kidneys also showed significantly less glomerular sclerosis in OKY-046 treated animals. The efficacy of OKY-046 was monitored by measurements of serum TXB2 levels and of glomerular production of TXB2 (and other prostaglandins); amounts of TXB2 were significantly reduced in the OKY-046 group. It is concluded that blockade of thromboxane generation has been successful in ameliorating the functional and structural lesions in this model of renal disease, providing further support to the thesis that thromboxane is an important mediator in events leading to eventual chronic renal failure and sclerosis. Discover the world's research ... In another model of progressive renal insufficiency that shares many biologic similarities with the human condition, immune complex nephritis induced by ferritin-anti-ferritin complexes in DahI-salt sensitive rats, a thromboxane synthase inhibitor, ameliorated urinary protein excretion and renal function [134] . Histological examination of the kidney showed that animals given the thromboxane synthase inhibitor were also significantly protected from glomeruloscberosis. ... ... proteinuria [102] Puromycin nephrosis (rat) proteinuria [103] Passive Heymann nephritis proteinuria [105] (rat) STZ-induced diabetes (rat) TxB [107] . albuminuria, GFR [107] Milan normotensive strain glomeruli [1191 proteinuria [1101 (rat) Nephrotoxic nephritis (rabbit) glomeruli [112] 1 proteinuria, ' GFR [112] CsA nephrotoxicity (rat) glomeruli [121] ' TxB2 [119,120,121] 2,3-dinor-TxB [120,121] 1 GFR [119] Endotoxin-induced ARF (rat) cortex [122] 1' GFR and RPF [122] Ureteral obstruction (rat, kidney microsomes 1' GFR and RBF [124] rabbit) [123] Renal allograft rejection (rat) 1 Dahl-S strain (rat) glomeruli [134] proteinuria, GFR, I FSG [134] Noninsulin-dependent diabetes cortex type IV collagen mRNA [ ... ... proteinuria [102] Puromycin nephrosis (rat) proteinuria [103] Passive Heymann nephritis proteinuria [105] (rat) STZ-induced diabetes (rat) TxB [107] . albuminuria, GFR [107] Milan normotensive strain glomeruli [1191 proteinuria [1101 (rat) Nephrotoxic nephritis (rabbit) glomeruli [112] 1 proteinuria, ' GFR [112] CsA nephrotoxicity (rat) glomeruli [121] ' TxB2 [119,120,121] 2,3-dinor-TxB [120,121] 1 GFR [119] Endotoxin-induced ARF (rat) cortex [122] 1' GFR and RPF [122] Ureteral obstruction (rat, kidney microsomes 1' GFR and RBF [124] rabbit) [123] Renal allograft rejection (rat) 1 Dahl-S strain (rat) glomeruli [134] proteinuria, GFR, I FSG [134] Noninsulin-dependent diabetes cortex type IV collagen mRNA [ ... Thromboxane synthesis and action within the kidney Article Giuseppe Remuzzi Garret A. FitzGerald Carlo Patrono Thromboxane (Tx) A2 is a labile derivative of arachidonic acid metabolism that amplifies the platelet response to a variety of aggregating agents [1]. In addition, TxA2 contracts vascular smooth muscle [2] and glomerular mesangial cells [3] through receptor-mediated actions, resulting in increased intracellular calcium [4–6]. TxA2 is formed by the sequential cyclooxygenation and peroxidation of arachidonic acid to the prostaglandin (PG) endoperoxides, PGG2 and PGH2. The last of these compounds is then transformed to TxA2 by a specific TxA2 synthase. Platelets represent a major source of TxA2 formed in vivo under physiological conditions. However, TxA2 synthase is widely distributed in other cells, particularly in macrophages, in the lung, peritoneum and kidney [7, 8], which may augment their contribution to systemic TxA2 biosynthesis in disease states. The most convincing evidence for the biological importance of TxA2 and its precursor endoperoxides derives from the beneficial effects of aspirin in platelet-mediated vascular occlusive disease [9]. Aspirin irreversibly inhibits platelet cyclooxygenase activity by acetylating a serine residue of the enzyme PGG/H synthase [10, 11]. This mechanism is presumed to underlie its effectiveness in preventing death in unstable angina [12–14] and in patients who have suffered a myocardial infarction [15], conditions in which TxA2 biosynthesis is augmented [16]. More recently, evidence has accumulated to support a role for these eicosanoids in the pathogenesis of various forms of renal disease. The purpose of this review will be to consider the role of TxA2 within the kidney and to consider the potential therapeutic benefit which might derive from modulating TxA2 synthesis and/or action by pharmacological or dietary intervention. ... 14,15 In these processes, thromboxane A 2 (TXA 2 ) plays a crucial role in the progression of chronic renal disability over the course of inflammation-implicated ROS in SHRSP 16 or SHR, 17 and the expression of TXA 2 and/or the prostaglandin endoperoxide (PGH 2 ) receptor (TPR) are shown to increase because of salt loading in the rat cortical kidney. 18,19 Thromboxane A 2 , or its stable analogue U-46,619, reduces renal blood flow (RBF) and the glomerular filtration rate (GFR), and potentiates tubuloglomerular feedback (TGF), 19,20 platelet aggregation 21 and monocyte chemoattractant protein-1 (MCP-1) production via the induction of nuclear factor (NF) κB and activating protein 1 (AP-1) binding activity, 22 vascular smooth muscle contraction, 23 and the production of extracellular matrix proteins. 24 The TXA 2 synthase inhibitor Dazmegrel increases prostaglandin E2 (PGE 2 ) synthesis, 20 which preserves kidney function. ... Thromboxane A2 receptor antagonist (ONO‐8809) attenuates renal disorders caused by salt overload in stroke‐prone spontaneously hypertensive rats Article Full-text available Yusuke Nagatani Toshihide Higashino Kosho Kinoshita Hideaki Higashino Epidemiological and clinical studies have demonstrated that excessive salt intake causes severe hypertension and exacerbates organ derangement, such as in chronic kidney disease (CKD). In this study, we focused on evaluating the histological and gene expression effects in the kidneys of stroke‐prone spontaneously hypertensive rats (SHRSP) with a high salt intake and the thromboxane A2/ prostaglandin H2 receptor (TPR) blocker ONO‐8809. Six‐week‐old SHRSPs aged 6 weeks, were divided into three groups and were fed normal chow containing 0.4% NaCl, 2.0%NaCl, or 2.0%NaCl +ONO‐8809 (0.6 mg/kg p.o. daily). Histological analyses with immunohistochemistry and a gene expression assay with a DNA kidney microarray were performed after eight weeks. The following changes were observed in SHRSPs with the high salt intake. Glomerular sclerotic changes were remarkably observed in the juxtamedullary cortex areas. The ED1, monocyte chemoattractant protein‐1 (MCP‐1), nitrotyrosine, and hypoxia inducible factor 1α (HIF‐1α) staining areas were increased in the glomeruli and interstitial portion of the kidneys. The genesTbxa2r (which encodes TPR), Prcp, and Car7 were significantly under‐expressed in the kidneys. The plasma 8‐isoprostane level was significantly elevated and was attenuated with the ONO‐8809 treatment. Thromboxane A2 (TXA2) and oxidative stress exaggerated renal dysfunction in the salt‐loaded SHRSPs, and ONO‐8809 as a TPR blocker suppressed these changes. Therefore, ONO‐8809 is a candidate drug to prevent CKD in hypertensive patients when CKD is associated with a high salt intake. ... Despite being lower than in healthy controls, serum Tx B 2 s howed a weak, but significant independent relationship to the rate of progression of renal failure in non-diabetics. This finding is of interest since thromboxane synthetase inhibitors protect the kidney in both the renal ablation [180] and the Dahl-S rat models of progressive C R F [181] . In the former study, amelioration of progressive C R F could not be explained by reduction in blood pressure, renal hypertrophy or glomerular hyperfiltation (which, if anything, was increased). ... Haemostasis in progressive renal failure Thesis Jan 1991 Michael Patrick Gordge This thesis describes a series of clinical and haematological studies of patients with chronic renal failure. My aim was to investigate the role of haemostatic abnormality in two aspects of renal disease: (1) The bleeding tendency of uraemia. (2) The progression of renal failure. (1) In the first part of the thesis I show that anaemia appears to be the most important determinant of uraemic bleeding. The development of a prolonged bleeding time in the early stages of renal failure was documented, and experiments were performed to identify platelet functional abnormalities which might develop in parallel, and hence explain the haemorrhagic defect. The only significant relationship which emerged was a negative correlation between the haematocrit and the bleeding time. This was further investigated by studying platelet function during correction of anaemia with recombinant human erythropoietin. Bleeding time was shortened following erythropoietin, by a degree which correlated with the increase in the haematocrit, but not with any changes in platelet reactivity. A study of platelet aggregation in whole blood showed an aggregation-enhancing effect of uraemic red cells which was not evident with normal erythrocytes. (2) In the second part of the thesis, increased blood viscosity and intravascular haemostatic activation were demonstrated in both diabetic and non-diabetic patients with progressive renal disease, abnormalities which might promote non-immune glomerular injury and hence the progression of renal failure. It was not clear, however, whether these changes represented cause or effect of disease, since in multiple regression analysis, proteinuria emerged as the major independent determinant of progression. A clinical study of antiplatelet therapy in progressive renal failure showed a slowing of progression in half the patients treated, and, in diabetic nephropathy, a significant reduction in proteinuria. These results suggest a partial role for haemostasis in the progression of renal injury. ... TXA2, or its stable analog, U-46,619, reduced renal blood flow (RBF) and glomerular filtration rate (GFR); and potentiated tubuloglomerular feedback (TGF) [19][20], platelet aggregation [21], and monocyte chemoattractant protein-1 (MCP-1) production via the induction of nuclear factor (NF) κB and activating protein 1 (AP-1) binding activity [22], vascular smooth muscle contraction [23] , and the production of extracellular matrix proteins [24]. The TXA2 synthase inhibitor Dazmegrel, increased PGE2 synthesis [20], which preserved kidney function. ... Thromboxane A2 Receptor Antagonist (ONO-8809) Attenuates the Renal Disorders Caused by Salt-Overload in Stroke-Prone Spontaneously Hypertensive Rats Preprint Jan 2021 Yusuke Nagatani Toshihide Higashino Kosho Kinoshita Hideaki Higashino Background. Epidemiological and clinical studies demonstrated that excessive salt intake causes severe hypertension and exacerbated organ derangement such as chronic kidney disease (CKD). In this study, we focused on evaluating histological and gene-expression findings in the kidney using stroke-prone spontaneously hypertensive rats (SHRSP) with high-salt intake and thromboxane A2/ prostaglandin H2 receptor (TPR) blocker ONO-8809. Methods. SHRSP aged 6 weeks were divided into three groups eating normal chow containing 0.4% NaCl, 2.0%NaCl, or 2.0%NaCl +ONO-8809 (0.6mg/kg p.o. daily). Histological analyses with immunohistochemistry and a gene-expression assay with a DNA kidney microarray were performed after 8 weeks. Results. The following changes were observed with high-salt intake. Glomerular sclerotic changes were remarkably observed in the juxtaglomerular cortex areas. ED1, MCP-1, nitrotyrosine, and HIF-1α staining areas were increased in the glomeruli and interstitial portion. Tbxa2r which encodes TPR, Prcp, and Car7 were significantly underexpressed in the kidney. The plasma 8-isoprostane level was significantly elevated, and was attenuated with ONO-8809 treatment. Conclusion. TXA2 and oxidative stresses exaggerated renal dysfunction in salt-loading SHRSP, and ONO-8809 as a TPR blocker suppressed these changes. Therefore, ONO-8809 is a candidate drug to prevent CKD for hypertensive patients associated with high-salt intake. ... Chronic administration of a thromboxane synthesis inhibitor almost completely prevents the decrease in GFR and the hypertension in the SHR. 6 In addition, thromboxane receptor blockade attenuates the reduction in GFR caused by high salt diet in Dahl salt sensitive rats, 16 and a similar beneficial effect on renal function is observed in diabetes mellitus 17 and after acute cyclosporine administration in rats. 18 Moreover, acute infusion of a thromboxane mimetic was reported to decrease GFR through an afferent arteriolar constriction action. ... Inhibition of Thromboxane Synthesis Attenuates Insulin Hypertension in Rats Article Oct 1997 Henry L. Keen Chronic insulin infusion in rats increases mean arterial pressure (MAP) and reduces glomerular filtration rate (GFR), but the mechanisms for these actions are not known. This study tested whether thromboxane synthesis inhibition (TSI) would attenuate the renal and blood pressure responses to sustained hyperinsulinemia. Male Sprague-Dawley rats were instrumented with arterial and venous catheters, and MAP was measured 24 h/day. After 4 days of baseline measurements, endogenous synthesis of thromboxane was suppressed in 7 rats by infusing the thromboxane synthetase inhibitor, U63557A, intravenously (30 μg/kg/min) for the remainder of the experiment; 7 other rats received vehicle. Baseline MAP was not significantly different between vehicle and TSI rats (96 ± 1 v 99 ± 1 mm Hg). After 3 days of U63557A or vehicle, a 5-day control period was started, followed by a 7-day infusion of insulin (1.5 mU/kg/min, intravenously). Glucose (22 mg/kg/min, intravenously) was infused along with insulin to prevent hypoglycemia. In the control period, MAP was not different between vehicle and TSI rats (99 ± 2 v 100 ± 1 mm Hg), but MAP increased throughout the 7-day infusion period only in the vehicle rats with an average increase in blood pressure of 7 ± 2 mm Hg. In the control period, GFR was lower in vehicle rats compared with TSI rats (2.5 ± 0.1 v 3.1 ± 0.2 mL/min, P = .06), and the decrease to 81% ± 4% and 91% ± 6% of control, respectively, during insulin was significant only in the vehicle rats. All variables returned toward control during a 6-day recovery period. These results suggest that full expression of hypertension and renal vasoconstriction during hyperinsulinemia in rats is dependent on a normal ability to synthesize thromboxane. ... In contrast to SHR, the depressor effect is not obtained in hypertensive Dahl rats, although blockage of TXA 2 synthetase ameliorates renal functional and structural lesions. 23, 24 Gomi et al 24 postulated that the abnormality of renal thromboxane seems to play a minor role in the development of hypertension in DS rats in contrast to SHR. ... Endothelium-Derived Contracting Factor in Carotid Artery of Hypertensive Dahl Rats Article Aug 1999 Ming-Sheng Zhou Yasuhiro Nishida Qing-Hui Chen Hiroaki Kosaka The present study is designed to investigate whether acetylcholine (ACh) elicits an endothelium-derived contracting factor (EDCF) and whether it contributes to decreased relaxant response induced by ACh in Dahl rats. Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a 0.4% NaCl or an 8% NaCl diet for 4 weeks. High sodium intake significantly increased blood pressure in DS rats but not in DR rats. The carotid rings were suspended for isometric tension recording. ACh caused an endothelium-dependent contraction in carotid rings from hypertensive DS rats but not from normotensive Dahl rats. Atropine, indomethacin, SQ29548, or ONO-3708 (prostaglandin H(2) [PGH(2)]/thromboxane A(2) [TXA(2)] receptor antagonist) abolished ACh-induced contraction, and OKY-046 (inhibitor of TXA(2) synthetase) partially attenuated the contraction. High sodium intake significantly enhanced contraction evoked by U46619, a PGH(2)/TXA(2) receptor agonist, in both DS and DR rats. In contrast, ACh-induced relaxation was significantly depressed in the rings from hypertensive DS rats, and ONO-3708 partially improved the depressed relaxation. Administration of ONO-8809 (an orally active PGH(2)/TXA(2) receptor antagonist; 30 micrograms per body per day) for 4 weeks neither reduced blood pressure nor improved the depressed ACh-induced relaxation in hypertensive DS rats. These results suggest that ACh causes release of EDCF in carotid rings of hypertensive DS rats, which is likely to be PGH(2) and TXA(2). The EDCF contributed in part to the depressed ACh-induced relaxation. ... The higher levels of COX-1 activity would result in higher levels of prostanoids in the renal vascular tissue, mesangium, and/or collecting tubules, while increased COX-2 would increase prostanoid levels in the macula densa, the surrounding loop of Henle and/or medullary interstitial cells. TXA 2 is a vasoconstrictor and associated with reduced renal blood flow and kidney damage (3,34, 54) , whereas the prostaglandins are vasodilators (42), so the balance of these prostanoids would dictate the net physiological effect. In diseased kidneys, the TXB 2 to prostaglandin ratios are higher than in normals, suggesting that the balance shifts toward a greater vasoconstrictory effect in diseased kidneys. ... Selectivity of cyclooxygenase isoform activity and prostanoid production in normal and diseased Han : SPRD-cy rat kidneys Article May 2006 Lori Warford-Woolgar Claudia Yu-Chen Peng Jamie N Shuhyta Harold M Aukema Renal prostanoids are important regulators of normal renal function and maintenance of renal homeostasis. In diseased kidneys, renal cylooxygenase (COX) expression and prostanoid formation are altered. With the use of the Han:Sprague-Dawley-cy rat, the aim of this study was to determine the relative contribution of renal COX isoforms (protein, gene expression, and activity) on renal prostanoid production [thromboxane B(2) (TXB(2), stable metabolite of TXA(2)), prostaglandin E(2) (PGE(2)), and 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha), stable metabolite of PGI(2))] in normal and diseased kidneys. In diseased kidneys, COX-1-immunoreactive protein and mRNA levels were higher and COX-2 levels were lower compared with normal kidneys. In contrast, COX activities were higher in diseased compared with normal kidneys for both COX-1 [0.05 +/- 0.02 vs. 0.45 +/- 0.11 ng prostanoids x min(-1) x mg protein(-1) (P < 0.001)] and COX-2 [0.64 +/- 0.10 vs. 2.32 +/- 0.22 ng prostanoids x min(-1).mg protein(-1) (P < 0.001)]. As the relative difference in activity was greater for COX-1, the ratio of COX-1/COX-2 was higher in diseased compared with normal kidneys, although the predominant activity was still due to the COX-2 isoform in both genotypes. Endogenous and steady-state in vitro levels of prostanoids were approximately 2-10 times higher in diseased compared with normal kidneys. The differences between normal and diseased kidney prostanoids were in the order of TXB(2) > 6-keto-PGF(1alpha) > PGE(2), as determined by higher renal prostanoid levels and COX activity ratios of TXB(2)/6-keto-PGF(1alpha), TXB(2)/PGE(2), and 6-keto-PGF(1alpha)/PGE(2). This specificity in both the COX isoform type and for the prostanoids produced has implications for normal and diseased kidneys in treatments involving selective inhibition of COX isoforms. ... Thromboxane (TXA 2 ) is another potent vasoconstrictor derived from the endothelium that has been suggested to influence the development of hypertension. Vascular and (or) renal production of TXA 2 has been demonstrated to be increased in different hypertensive animal models including spontaneously hypertensive rats, the Dahl salt-sensitive rats, angiotensin II salt-induced hypertensive animals, and in renovascular hypertension (Ishimitsu et al. 1988; Yamashita et al. 1988; Stahl et al. 1984;Mistry and Nasjletti 1989). ... Endothelin-1 blockade prevents COX2 induction and TXA 2 production in the fructose hypertensive rat Article Full-text available May 2007 Jihong Jiang Linda T Tran Harish Vasudevan John H McNeill Feeding rats with a high fructose diet results in insulin resistance and hypertension. Fructose-hypertensive rats (FHR) have increased vascular levels of endothelin-1 (ET-1) and thromboxane (TXA2). We have previously shown that chronic treatment with either the dual endothelin receptor blocker, bosentan, or the thromboxane synthase inhibitor, dazmegrel, prevented fructose-induced increases in blood pressure, suggesting that both ET-1 and TXA2 play important roles in the development of hyperinsulinemia/insulin resistance-associated hypertension. In this study, we investigated the potential interrelationship between ET-1 and TXA2 in the development of fructose-induced hypertension in vivo. Male Wistar rats were fed on a high fructose diet for 9 weeks. Either bosentan or dazmegrel treatment (daily by oral gavage) was initiated 3 weeks after the start of fructose feeding for a total duration of 6 weeks. At the end of drug treatment, blood and aorta were collected from each animal. Plasma thromboxane B2 (TXB2), a stable TXA2 metabolite, increased significantly in FHR and was reduced to control level by both chronic bosentan and dazmegrel treatment. Protein expression of cyclooxygenase 2 (COX2) was elevated significantly in FHR aortas and treatment with bosentan and dazmegrel corrected these changes. These results indicate that the actions of ET-1 in the aorta of FHR may be mediated through COX2-derived TXA2. Bosentan may prevent the development of hypertension in fructose-fed rats through inhibition of COX2 induction and subsequently the reduction in plasma TXA2. The effects of excess salt intake on the kidney metabolism in Sprague-Dawley rats Preprint Jan 2023 Satoshi Shimada Brian Hoffmann Chun Yang Allen W Cowley In the present study, novel methods were developed which allowed continuous (24/7) measurement of blood pressure (BP) and renal blood flow (RBF) in freely moving rats and the intermittent collection of arterial and renal venous blood to estimate kidney metabolic fluxes of O2 and metabolites. The study determined the effects of a high salt (HS) diet upon whole kidney O2 consumption and the metabolomic profiles of normal Sprague Dawley (SD) rats. A separate group of rats was studied to determine changes in the cortex (Cx) and outer medulla (OM) tissue metabolomic and mRNAseq profiles before and following the switch from a 0.4% to a 4.0% NaCl diet. Significant changes in the metabolomic and transcriptomic profiles occurred with feeding of the HS diet. A progressive increase of kidney O2 consumption was found despite a reduction in expression of most of the mRNA encoding enzymes of TCA cycle. Increased glycolysis was evident with the elevation of mRNA expression encoding key glycolytic enzymes and release of pyruvate and lactate from the kidney in the renal venous blood. Glycolytic production of NADH is used in either the production of lactate or oxidized via the malate aspartate shuttle. Aerobic glycolysis (e.g., Warburg-effect) may account for the needed increase in cellular energy. The study provides interesting and provocative new data of how normal kidneys respond to a HS diet and guides us toward deeper mechanistic studies examining the effects of a HS diet upon kidney metabolism. Defibrotide Treatment and Disease Progression in Patients with IgA Nephropathy and Impaired Renal Function at Diagnosis Article Apr 1997 Giovanni Maria Frasca' Mauro Martello Cristina Canova Vittorio Bonomini Defibrotide is an antithrombotic agent that is capable of increasing the synthesis and release of prostaglandin I2 from endothelial cells, and improving fibrinolysis. The aim of this study was to evaluate the effectiveness of defibrotide therapy in slowing down the rate of progression of immunoglobulin (Ig) A nephropathy in patients with impaired renal function at diagnosis. 20 such patients were randomised to receive either prednisolone for 6 months plus defibrotide for 2 years (group A) or a 6-month prednisolone course only (group B). No significant difference was found at baseline between the two groups with regard to renal function, daily protein excretion or renal histological lesions. After 24 months, patients in group A had a mean decrease in serum creatinine level of 14%, compared with a 9% increase observed in group B (p = 0.007). A 14% increase in creatinine clearance occurred in group A patients as opposed to a 12% decrease in group B (p = 0.003). Daily protein excretion was significantly reduced in group A relative to baseline (p = 0.02), while it did not change in group B. These results suggest that nonimmunological factors are important in the progression of IgA nephropathy and that drugs that improve renal haemodynamics can contribute to the maintenance of renal function. Vasoconstrictors and Renal Protection Induced by β-Selective Adrenoceptor Antagonist Bisoprolol Article Jun 1994 J CARDIOVASC PHARM A TP receptor (TP-R) mimetic causes salt-sensitive hypertension and renal afferent arteriolar vasoconstriction. TP-Rs mediate effects of ANG II on renal vascular resistance and drinking. Therefore, we investigated the hypothesis that thromboxane A(2) synthase (TxA(2)-S) and/or TP-R expression is regulated by salt and/or ANG II. Rats (n = 6) received high-salt (HS) or low-salt (LS) diets. Additional HS-diet rats received ANG II while other HS- and LS-diet rats received the AT(1) receptor (AT(1)-R) antagonist losartan. Excretion of thromboxane B(2) by conscious rats was increased with the HS diet compared with the LS diet (126 +/- 10 vs. 48 +/- 5 pmol/24 h, respectively; P < 0.01). The mRNA abundance for TP-Rs (relative to beta-actin) in the kidney cortex was enhanced 30% by the HS diet (P < 0.001) and was reduced 50% by the addition of ANG II (P < 0.001). However, during losartan administration, the effects of salt were reversed; mRNA more than doubled during the LS diet (P < 0.001). Similarly, the mRNA abundance for TP-Rs in the brain stem was reduced by 50% with the addition of ANG II (P < 0.001) and during losartan administration was almost doubled by the LS diet (P < 0.001). The mRNA abundance for TxA(2)-S in the kidney cortex also was increased many times with the HS diet (P < 0.001). In contrast, the mRNA for TxA(2)-S in the brain was unaffected by salt. ANG II did not affect TxA(2)-S at either site. During losartan administration, TxA(2)-S increased modestly in the brain stem with the LS diet. mRNA abundance for TP-Rs in the kidney cortex and brain stem is suppressed by ANG II acting on AT(1)-Rs. In the absence of AT(1)-Rs, expression of TP-Rs at both sites is enhanced by LS intake. In contrast, ANG II does not affect the mRNA abundance for TxA(2)-S. Expression of TxA(2)-S is enhanced by HS intake in the kidney cortex but by LS intake in the brain stem only during losartan administration. Thus TP-Rs are strongly dependent on ANG II acting on AT(1)-Rs, whereas TxA(2)-S is regulated differentially in the kidney cortex and brain stem by salt intake.
https://www.researchgate.net/publication/20191534_A_thromboxane_synthetase_antagonist_ameliorates_progressive_renal_disease_of_Dahl-S_rats
Mount Jefferson State Natural Area | NCpedia Mount Jefferson State Natural Area (formerly Mt. Jefferson State Park) North Carolina Division of Parks and Recreation, 2015; Revised by Jared Dease, Government and Heritage Library, January 2023 https://www.ncparks.gov/ Established: 1956, 1999 GPS Coordinates: 36.393564,-81.468012 Size: 975 acres Photograph of a small farming community in Jefferson, N.C. with Mount Jefferson in the distance, ca. 1920. The mountain was given the name "Mount Jefferson" at the time the park was created in 1956. Item H.19XX.313.27 from the collection of the N.C. Museum of History. Park Area History and Geology Mount Jefferson lies along the drainage divide between the north and south forks of the New River—one of the oldest rivers in North America and in the world. This drainage system had an important influence on the size and shape of the mountain. The mountain and its nearby peaks are remnants of a once lofty, mountainous region that existed throughout much of the western part of the state. Weathering and the erosive action of streams throughout millions of years wore away the softer, less resistant rocks. More resistant rocks, including the amphibolite and metagraywacke of Mount Jefferson, were slower to erode. These and other rocks comprise the peaks standing above their surrounding plateau. Though there is no evidence of permanentNative Americansettlements in the Ashe County area, game was plentiful and both theCherokeeand the Shawnee claimed it as a hunting ground. The first settlers in the area were from Virginia. Few North Carolinians, other than adventurous individuals likeDaniel Boone, had ventured westward beyond the Blue Ridge Mountains. Before theAmerican Revolution, Mount Jefferson was known asPanther Mountain, perhaps because of a legend that tells of a panther that attacked and killed a child there. Area residents gave the mountain other names until 1952 when Mount Jefferson received its official name. The mountain's name was chosen in honor of Thomas Jefferson and his father, Peter, who owned land in the area and surveyed the nearby North Carolina-Virginia border in 1749. Around the time of theCivil War, legend holds that the "caves" beneath Mount Jefferson's ledges served as hideouts for freedom-seeking enslaved people traveling to freedom on the Underground Railroad. Park Development By the 1930s people began to take an interest in creating widespread access to the mountain. The site as a park had its beginnings when theWorks Progress Administrationconstructed a two-mile road to the summit. In 1939, local officials sought to have the road improved, but the state could not provide funds for a private road. In order to get needed road improvements, two local residents who owned land on the mountain -- H.C. Tucker and J.B. Hash -- donated 26 acres, and the site became a state wayside park. In 1942, citizens petitioned the General Assembly to take the park as a state park, but the effort failed. In 1955, attempts were made again to establish the park as a state park; they failed once again due to legislation passed that year specifying a minimum size of 400 acres for state parks. Citizens then began campaigns to raise funds and land donations. By 1956 300 acres had been obtained by gift and an additional 164 acres by fundraising, sufficient to establish a state park. The mountain's named was changed to Mount Jefferson at the establishment of the state park. In 1974 the park was designated by the federal government as a National Natural Landmark, recognizing its natural heritage with undisturbed red oak forests and as a key example of existing oak-chesnut forests in the Southeast.  The state changed its designation to a state natural area in 1999. Park Ecology The slopes and summit of the mountain are home to a diverse population of trees, shrubs and wildflowers. This large variety of interesting and unusual plants qualified the area for designation as a national natural landmark by the National Park Service in 1974. The forests of the area vary with the altitude and the direction of the slope. At altitudes above 4,000 feet, an oak/chestnut forest dominates the slopes facing south, east and west. This forest is one of the best examples of its type in the southeastern United States. Beneath the canopy of oak is an understory of Catawba rhododendron, mountain laurel, flame azalea and dogwood. Wildflowers include trillium, pink lady slipper and false lily of the valley. Until the early 20th century, American chestnut trees were abundant in the area. The chestnut's rot-resistant wood was immensely valuable to early settlers for the construction of buildings and fences, and its large, sweet nuts provided food for humans and animals. Tragically, the chestnut blight, introduced from Europe in 1910, destroyed the species here and elsewhere. At the summit of Mount Jefferson, ghostly trunks stand; sprouts rise from the diseased roots and thrive until maturity when they become susceptible to the blight. On the north slopes, a cove forest includes red maple, yellow birch, tulip tree and basswood. In the understory are mountain ash, prairie willow, black huckleberry and mountain pepperbush. Hobblebush, mayapple, blue bead lily and other shrubs and herbs cover the forest floor. On the slopes below Luther Rock is a stand of big-toothed aspen trees. The big-toothed aspen is primarily a northern plant, found in North Carolina only in Ashe and Haywood counties. Trees growing on the northern ridges and slopes of Mount Jefferson are gnarled and dwarfed, averaging only about 20 feet. Their growth has been stunted by exposure to strong northerly winds and heavy loads of ice in winter. The animal life of the natural area has not been as well studied as the plant life but is typical of the western part of the state. Red squirrels, locally known as “boomers,” live in forests near the peak. Several species of small mice, including deer mice, and southern red-backed voles are also common. Bird life in these high-altitude forests includes several species not seen at lower elevations. Lucky visitors may catch a glimpse of a red-tailed hawk, the most common hawk in the area. Chestnut-sided warblers, Canada warblers and black-throated blue warblers, as well as rose-breasted grosbeaks, slate-colored juncos and white-breasted nuthatches nest in the woodlands. Their melodies are often heard with the song of the veery at dusk and dawn. The wing beats of flushed ruffed grouse often surprise hikers along the trail. The park's mature deciduous forests are home to many common mammals, including gray squirrels, southern flying squirrels, eastern chipmunks, red foxes, raccoons and Virginia opossums. Shrews, moles and mice also make their homes in the middle altitudes. Woodchucks and an occasional white-tailed deer inhabit the forest edges. Reptiles, such as skinks and small snakes, travel in and around rotting logs and other places offering food and seclusion. References: North Carolina Division of Parks and Recreation. Mount Jefferson State Natural Area.https://www.ncparks.gov/mount-jefferson-state-natural-area (accessed December 29, 2015). Additional Resources: North Carolina Division of Parks and Recreation. Mount Jefferson State Park General Management Plan.  January 1993.https://digital.ncdcr.gov/digital/collection/p16062coll9/id/215849(accessed December 29, 2015). North Carolina Division of Parks and Recreation. North Carolina State Parks.1965 . North Carolina Division of Parks and Recreation. North Carolina State Parks.1959. North Carolina Division of Parks and Recreation. North Carolina State Parks.1957. "Around Capitol Square." Burlington Daily Times News(Burlington, N.C.), October 20, 1951. "State Park Use Growing." High Point Enterprise(High Point, N.C.), June 6, 1965. Image Credits: [Small farm community in Jefferson, N.C., with mountain in the distance.] Photograph. ca. 1920. Item H.19XX.313.27, collection of the N.C. Museum of History.https://www.ncmuseumofhistory.org/collections(accessed December 29, 2015). Subjects: Natural resources Parks Places Origin - location: Mountains Ashe County From: NC Division of Parks and Recreation, NC Dept. of Natural and Cultural Resources
https://ncpedia.org/mount-jefferson-state-natural-area
The Euro and the battle of ideas Why is the Euro in trouble? Are philosophical differences between the founding countries to blame and can those differences be reconciled? Event The Euro and the battle of ideas Why is the Euro in trouble? Are philosophical differences between the founding countries to blame and can those differences be reconciled? Date and time 13 October 2016 10:30-12:30 Speakers Markus Brunnermeier Professor, Princeton University, Maria Demertzis Senior fellow, Bruegel Harold James Professor, Princeton University, Marco Buti Chief of Staff of the Commissioner for the economy, Paolo Gentiloni, European Commission SUMMARY See below for the video and audio and the event materials At this event Markus Brunnermeier and Harold James presented their new book The Euro and the Battle for Ideas(co-authored with Jean-Pierre Landau). A joint work which combined not only their different backgrounds (the authors are, respectively, an economist, a historian and a former deputy governor of the Banque de France), but also their different national perspectives. The authors outlined how the political response to the euro crisis has led to a seismic shift of power in Europe. With the notable expection of the ECB which gained significantly in stature and influence, decision-making capacity moved from European institutions to the capitals of member states, particularly Berlin and Paris. However, the differences between Northern (but above all German) and what are sometimes called Southern (but above all French) visions of the appropriate economic policy emerged with great clarity in the management of the crisis. In this regards, the authors contested the usual way of interpreting the political dynamics as simple result of a balancing between contrasting economic interests. Conversely, since material interests are always interpreted through the lens of ideas, they claimed that we should take into account more the different economic philosophies developed in each country to fully understand the origin and the rationale of any European political dispute. The declared attempt of the book is to trace the long-term historical, intellectual, and cultural origins of the “French” and “German” economic traditions. The authors claimed that the indeterminate cohabitation of these two traditions of economic and political thought, in addition to mutual incomprehension and national stereotyping, prevented an adequate response during the crisis and led to downward compromises on the future design of the European Union. In terms of policy contribution, the authors supported the proposal presented in 2011 to create Euro Safe Bonds (“ESBies”), as a practical solution to permanently break the link between sovereign debt and the stability of banking sector in a manner amenable to different political (and philosophical) positions. According to the main discussant, Marco Buti, the book provides important insights with respect to the origin and the persistence of clashing economic cultures within European project. He agreed with the opinion expressed by the authors regarding the shift towards intergovernamentalism, reclaiming, nevertheless, an active role of the European Commission during the crisis, bringing the EFSM and the Banking Union as example of important policy proposals. He added to the discussion evidence that economic differences across EA countries widened during the first years of EMU and linked them to the increasingly diverging social and political preferences. To bridge these differences and address the transition to an enchanced European governance, he called for the parallel progress on risk sharing and risk reduction in the current phase of development of Banking and Capital Markets Union. A relevant obstacle, however, is represented by the fact that these over-present differences of economic ideas increased substantially during the crisis. After several year of digging trenches around established intellectual and theoretical propositions, Marco Buti warned that economics ideas tranformed even into ideologies, from which an open discussion in the quest for a compromise becomes more difficult. Finally, he showed interest for the proposal of the ESBies, as a good balance between the non-mutualisation concerns (German position) and the (French) necessity to address systemic risks, but it would require a nontrivial transition in the current sovereign bonds market. A relevant comment from the audience came from Mario Monti, according to who the reciprocal interaction between European political authorities and the ECB have been somewhat underestimated by the authors (at least in their presentation). As an example of this, he recalled the importance of the decisions taken during the Euro Area Summit in 29 June 2012, which thereafter represented the political pre-conditions for Mario Draghi’s “whatever it takes” speech. Moreover, the discussions during that Summit represented another suggestive example of the battle of ideas evoked by the authors. In that context, indeed, the German position emphasizing the need to put one’s house in order first (“often falling into the fallacy of composition”) severely confronted in the quest of compromise (truly necessary at that time) with the French and others’ ones pointing more to systemic problems requiring systemic responsabilities. In conclusion Guntram Wolff made two points. Firstly, he questioned the “shift towards intergovernmentalism” argument identified by the authors since it provided a wrong description of the events: in fact there was nothing to be shifted. What actually occurred and eventually added political tension during the crisis was the difficult creation of new mechanisms for fiscal risk-sharing across countries, which was not originally included in the Maastricht treaty. Secondly, regarding financial stability issues, he agreed on the necessity to complete the Banking Union, while arguing that the real missing part is a proper fiscal backstop, and not necessarily the ESBies. Event notes by Filippo Biondi , Research Assistant. AUDIO & VIDEO RECORDING event materials Presentation by Markus Brunnermeier and Harold James Presentation by Marco Buti Theme Macroeconomic policies European governance Keyword Euro crisis euro area Language English
https://www.bruegel.org/event/euro-and-battle-ideas
Goldfarb v. Bronston - Florida - Case Law - VLEX 894105920 0: [object Object]. 1: [object Object]. 2: [object Object]. 3: [object Object] Florida Goldfarb v. Bronston Court United States State Supreme Court of Florida Citation 17 So.2d 300,154 Fla. 180 Parties GOLDFARB v. BRONSTON et al. Decision Date 15 February 1944 17 So.2d 300 154 Fla. 180 GOLDFARBv.BRONSTON et al. Florida Supreme Court February 15, 1944 Rehearing Denied March 6, 1944. E. F. P. Brigham, of Miami, for appellant. Edward E. Fleming and Bernstein & Hodsdon, all of Miami, for appellee. BROWN, Justice. We are here dealing with a motion to dismiss an appeal taken by the plaintiff below from what purports to be a final judgment in favor of the defendant below on four counts of an eight count declaration in a common law action for damages. On July 5, 1943, Irwin Goldfarb, by his next friend and father, Albert M. Goldfarb, filed a declaration consisting of four counts against Walter Bronston, Jr., a minor, and Walter Bronston, Sr., to recover damages for serious personal injuries, alleged to have been permanent, caused by the negligence of the defendants. The defendants filed a demurrer to the declaration on August 2, 1943. On October 25, 1943, Irwin Goldfarb having died as a result of the alleged injuries, his father Albert M. Goldfarb, as administrator of the estate of Irwin Goldfarb, filed a petition to revive said suit. On the same day, the Circuit Court made an order in which it stated that it appearing to the court [154 Fla. 182] 'that the cause of action therein sued on survives said death,' the cause 'is hereby revived in the name of Albert M. Goldfarb as administrator of the estate of Irwin Goldfarb deceased, and the plaintiff's pending declaration in the cause is amended by the substitution of this new party plaintiff in lieu of the deceased plaintiff, Irwin Goldfarb.' On the same date, October 25, 1943, the plaintiff administrator amended his declaration by adding four additional counts, claiming damages to the estate of Irwin Goldfarb as a result of his death, based on the prospective future earnings of Irwin Goldfarb [17 So.2d 301] which he would have earned after he had obtained his majority and during his life expectancy had he not died. On November 1, 1943, the defendants filed an adoption and application of the demurrer previously filed to the original declaration to the 5th, 6th, 7th and 8th counts which had been filed as an amendment to the original declaration, and on the same day defendants filed their motion to strike the first four counts of the plaintiff's original declaration as amended upon the ground that the damages alleged in said counts were not recoverable by said administrator. On November 19, 1943, the court granted the motion to strike the first four counts of plaintiff's declaration and the plaintiff sought to have this order reviewed by this court by certiorari, but the petition was by this court, on December 23, 1943, denied. On December 28, 1943, the circuit court entered an order purporting to be a final judgment reading as follows: 'The Plaintiff having elected to stand on Counts One, Two, Three and Four of his declaration without amendment, the Court having stricken the same from Plaintiff's declaration; now, therefore, it is 'Considered, ordered and adjudged that the Plaintiff take nothing by said... 8 practice notes Southern Ry. Co. v. Bowling, No. 60-622 United States Court of Appeal of Florida (US) April 24, 1961 ...one. Obviously it is not a final order, as it would have been if the cause had been dismissed. See Page 439 Goldfarb v. Bronston, 154 Fla. 180 , 17 So.2d 300. In denying the motion, the court is not disposing of the case; it simply decides that the inconvenience to the defendant of the chose...... Raphael v. Carner, No. 289 United States Court of Appeal of Florida (US) January 17, 1967 ...only on appeal from a subsequent judgment or order finally adjudicating the entire cause or complaint. Goldfarb v. Bronston, 1944, 154 Fla. 180 , 17 So.2d 300; Morse v. Hendry Corporation, Fla.App.1965, 177 So.2d 31. Further, an order which dismisses a complaint but also grants leave to amen...... Bailey v. Allstate Ins. Co., No. 68--333 United States Court of Appeal of Florida (US) February 5, 1969 ...Chastain v. Embry, id. See, also, Strazzulla et al. v. Hinson (Fla.App.2d 1959), 113 So.2d 419; and Goldfarb v. Bronston et al. (1944), 154 Fla. 180 , 17 So.2d 3 State ex rel. Royal Ins. Co. v. Barrs (Fla.1924), 87 Fla. 168, 99 So. 668. 4 See Craft v. Clarembeaux, (Fla.App.2d 1964), 162 So.2...... Russell v. Russell, No. 4-86-0876 United States Court of Appeal of Florida (US) April 29, 1987 ...an order's being non-appealable until a further order dismissing the complaint has been rendered. See, for example Goldfarb v. Bronston, 154 Fla. 180 , 184, 17 So.2d 300, 301 (1944) and Gates v. Hayner, 22 Fla. 325 (1886), cited therein. See, also, Baker v. Colley, 104 So.2d 473 (Fla. 2d DCA...... 8 cases Southern Ry. Co. v. Bowling, No. 60-622 United States Court of Appeal of Florida (US) April 24, 1961 ...one. Obviously it is not a final order, as it would have been if the cause had been dismissed. See Page 439 Goldfarb v. Bronston, 154 Fla. 180 , 17 So.2d 300. In denying the motion, the court is not disposing of the case; it simply decides that the inconvenience to the defendant of the chose...... Raphael v. Carner, No. 289 United States Court of Appeal of Florida (US) January 17, 1967 ...only on appeal from a subsequent judgment or order finally adjudicating the entire cause or complaint. Goldfarb v. Bronston, 1944, 154 Fla. 180 , 17 So.2d 300; Morse v. Hendry Corporation, Fla.App.1965, 177 So.2d 31. Further, an order which dismisses a complaint but also grants leave to amen...... Bailey v. Allstate Ins. Co., No. 68--333 United States Court of Appeal of Florida (US) February 5, 1969 ...Chastain v. Embry, id. See, also, Strazzulla et al. v. Hinson (Fla.App.2d 1959), 113 So.2d 419; and Goldfarb v. Bronston et al. (1944), 154 Fla. 180 , 17 So.2d 3 State ex rel. Royal Ins. Co. v. Barrs (Fla.1924), 87 Fla. 168, 99 So. 668. 4 See Craft v. Clarembeaux, (Fla.App.2d 1964), 162 So.2...... Russell v. Russell, No. 4-86-0876 United States Court of Appeal of Florida (US) April 29, 1987 ...an order's being non-appealable until a further order dismissing the complaint has been rendered. See, for example Goldfarb v. Bronston, 154 Fla. 180 , 184, 17 So.2d 300, 301 (1944) and Gates v. Hayner, 22 Fla. 325 (1886), cited therein. See, also, Baker v. Colley, 104 So.2d 473 (Fla. 2d DCA......
https://case-law.vlex.com/vid/goldfarb-v-bronston-894105920
Genes | Free Full-Text | The 5′-3′ Exoribonuclease XRN4 Regulates Auxin Response via the Degradation of Auxin Receptor Transcripts Auxin is a major hormone which plays crucial roles in instructing virtually all developmental programs of plants. Its signaling depends primarily on its perception by four partially redundant receptors of the TIR1/AFB2 clade (TAARs), which subsequently mediate the specific degradation of AUX/IAA transcriptional repressors to modulate the expression of primary auxin-responsive genes. Auxin homeostasis depends on complex regulations at the level of synthesis, conjugation, and transport. However, the mechanisms and principles involved in the homeostasis of its signaling are just starting to emerge. We report that xrn4 mutants exhibit pleiotropic developmental defects and strong auxin hypersensitivity phenotypes. We provide compelling evidences that these phenotypes are directly caused by improper regulation of TAAR transcript degradation. We show that the cytoplasmic 5′-3′ exoribonuclease XRN4 is required for auxin response. Thus, our work identifies new targets of XRN4 and a new level of regulation for TAAR transcripts important for auxin response and for plant development. Background: The 5′-3′ Exoribonuclease XRN4 Regulates Auxin Response via the Degradation of Auxin Receptor Transcripts by David Windels 1,2,* and Etienne Bucher 1,2 1 Botanical Institute, University of Basel, Zurich-Basel Plant Science Center, Part of the Swiss Plant Science Web, Schönbeinstrasse 6, 4056 Basel, Switzerland 2 IRHS, Agrocampus-Ouest, INRA, Université d’Angers, SFR 4207 QuaSaV, 49071 Beaucouzé, France * Author to whom correspondence should be addressed. Genes 2018 , 9 (12), 638; https://doi.org/10.3390/genes9120638 Received: 26 November 2018 / Revised: 13 December 2018 / Accepted: 13 December 2018 / Published: 17 December 2018 (This article belongs to the Section Plant Genetics and Genomics ) Auxin is a major hormone which plays crucial roles in instructing virtually all developmental programs of plants. Its signaling depends primarily on its perception by four partially redundant receptors of the TIR1/AFB2 clade (TAARs), which subsequently mediate the specific degradation of AUX/IAA transcriptional repressors to modulate the expression of primary auxin-responsive genes. Auxin homeostasis depends on complex regulations at the level of synthesis, conjugation, and transport. However, the mechanisms and principles involved in the homeostasis of its signaling are just starting to emerge. We report that xrn4 mutants exhibit pleiotropic developmental defects and strong auxin hypersensitivity phenotypes. We provide compelling evidences that these phenotypes are directly caused by improper regulation of TAAR transcript degradation. We show that the cytoplasmic 5′-3′ exoribonuclease XRN4 is required for auxin response. Thus, our work identifies new targets of XRN4 and a new level of regulation for TAAR transcripts important for auxin response and for plant development. Keywords: XRN4 ; RNA Decay ; Auxin 1. Introduction Plant growth, organogenesis, and diverse responses to environmental changes are control by auxins plant hormones [ 1 , 2 ]. The perception of Auxin signaling depends on auxin receptors of the TAAR [TRANSPORT INHIBITOR RESPONSE 1 (TIR1)/AUXIN SIGNALLING F-BOX PROTEIN 2 (AFB2)] family. There are four TAARs genes which have partially-redundant functions [ 3 , 4 , 5 ]. TAAR proteins belong to SKIP/CULLIN/F-BOX (SCF)-ubiquitin ligase complexes and in presence of auxins can form a complex with AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) transcriptional repressors [ 6 , 7 , 8 ]. These AUX/IAA proteins are ubiquitinated and degraded by the 26S proteasome [ 6 ]. The degradation of AUX/IAA induces the release of AUXIN RESPONSE FACTOR (ARF) transcription factors. ARFs leads to the activation (5 ARFs) or to the repression (18 ARFs) of primary auxin-responsive genes [ 1 , 9 , 10 ]. Auxin signaling is an extremely robust system which invokes complex homeostatic regulations at the levels of synthesis, conjugation, and transport [ 2 , 11 ]. Moreover, recent works, including ours, have shown that it also involves complex regulation at the level of signaling [ 12 , 13 , 14 , 15 , 16 , 17 ]. Thus, auxin signaling homeostasis also appears to depend on the homeostasis of TAAR transcripts and to involve tight regulation orchestrated by the microRNA miR393 and by a complex network of secondary small interfering RNAs (siRNAs), the siTAARs [ 13 , 14 , 15 , 18 ]. Importantly, this regulation is highly significant for auxin signaling, since it appears necessary for the production of proper signaling outputs important for plant development [ 16 ]. RNA surveillance and RNA decay encompass a large array of ubiquitous regulatory mechanisms involved in controlling the integrity and turn-over of cellular RNAs [ 19 , 20 ]. These mechanisms depend on specific recognition factors and on the activity of endonucleases and of 5′-3′ and 3′-5′ exonucleases to degrade decapped, improperly terminated, improperly processed or improperly spliced RNA molecules [ 19 , 20 ]. In Arabidopsis, the family of 5′-3′ exonucleases comprises 3 proteins: XRN2 and XRN3, which are localized in the nucleus and are involved in processing of pre-rRNA and for surveillance of proper termination of transcription [ 21 , 22 ], and XRN4, which is localized in the cytoplasm and is implicated in the degradation of a subset of 3′ RNA fragments generated upon microRNA-guided cleavages [ 23 , 24 , 25 , 26 ]. Importantly, none of the XRN proteins of plants seem to have a general role in mRNA turn-over [ 23 , 24 , 26 ]. Indeed, although the steady-state level of many transcripts is increased in xrn4 mutants, none of these transcripts exhibit altered turn-over rate [ 27 ]. For example, although XRN4 is an important component of signaling by the plant hormone ethylene, its involvement in this signaling pathway, via regulation of EIN3 BINDING F-BOX1 and 2 (EBF1 and EBF2) messenger RNA (mRNA) levels, was shown to be indirect [ 28 , 29 , 30 , 31 ]. Still recently, Merret et al. found that many transcripts may be targeted by XRN4 under heat stress, and at least eight of those were directly degraded [ 32 ]. We report here that xrn4 mutant plants exhibit pleiotropic developmental defects and hypersensitive responses to auxin that are caused by their inability to generate accurate auxin response. We show that xrn4 mutants are unable to properly regulate the turn-over of TIR1/AFB2 auxin receptor (TAAR) transcripts and that chemical suppression of TAAR functions leads to suppression of certain developmental defects observed in xrn4 plants. Thus, our data provide evidences showing that XRN4 is a component and a direct regulator of the auxin signaling pathway. Our work identifies new direct XRN4 target RNAs and a new layer of regulation of TAAR transcripts. 2. Materials and Methods 2.1. Plant Material, Growth Conditions, and Treatments Arabidopsis thaliana plants were grown in soil under long day conditions (16 h 10,000 lux lights at 21 °C/8 h dark at 16 °C) in growth chambers at 65% relative humidity [ 15 , 16 , 33 ]. Assays for inhibition of root elongation were done as described in [ 4 ]. For scoring the incidence of leaf serration, seeds were germinated and grown for 28 days on MS medium supplemented with PEO-IAA (alpha-(phenylethyl-2-oxo)-IAA) in dimethyl sulfoxide (DMSO) or DMSO alone as a control in 5.5 cm high Petri dishes. For studies of IAA3pro:GUS, IAA12pro:GUS, and DR5pro:GUS expression, seven day old seedlings were incubated in MS medium containing 10 µM 2,4-D in ethanol or ethanol alone as a control for the time indicated before proceeding to staining. For studies of AXR3-NT:GUS fusion protein stability, seven day old seedlings were placed in water at 37 °C for 2 h to induce the expression of the HSpro:AXR3-NT:GUS gene and incubated for 30 min at room temperature before proceeding to GUS staining. For the treatments, either 10 µM 2,4-D were added to the solution 4 h before the heat shock. 2.2. Histochemical GUS Assays Arabidopsis seedlings were incubated into a staining solution containing 1 mM X-Gluc in 100 mM Na 3 PO 4 (pH 7.2), 0.1% Triton X-100, 5 mM K 3 Fe(CN) 6 , and 5 mM K 4 Fe(CN) 6 for 24 h at 37 °C in the dark. Seedlings were then cleared in 70% ethanol for two days and mounted in 50% v/v glycerol before observations. 2.3. RNA Decay Assay For determining the rate of RNA decay, seeds were grown in short day (SD) conditions for 14 days in liquid MS medium and treated with 0.6 mM cordycepin as described in [ 34 ]. Tissues were collected at the indicated intervals before RNA extraction. Half-life times of transcripts were estimated by calculation of signal decay rate per minute. 2.4. RNA Preparation and RNA Analysis RNA extractions and Northern blot hybridizations were done as described in [ 15 ]. 3. Results 3.1. XRN4 Defective Plants Exhibit Pleiotropic Developmental Defects We observed that mutants impaired in the function of XRN4 exhibit developmental abnormalities which resulted in an increase of their global stature and altered the morphology of several of their organs, as for the T-DNA insertion allele xrn4-3 ( Figure 1 ). As exemplified in Table 1 , ein5-7 mutants, another allele of xrn4 , develop longer leaves and generate significantly more of these leaves (Student t -test, p = 1.2 × 10 −5 ) than the wild-type (wt) plants. Their rosettes are three times heavier than those of wt plants ( p = 4.4 × 10 −7 ), their stems have shorter internodes ( p = 2.7 × 10 −6 ), and they develop a greater number of flowers ( p = 1.9 × 10 −3 ). Their root system is also affected; primary roots are longer with less lateral roots ( p > 1.6 × 10 −5 ) than in wt plants. The morphology of their organs is also altered; the leaves develop significantly more serrations ( p > 3 × 10 −4 ) and the flowers are more often duplicated ( p = 3.1 × 10 −4 ) in xrn4 compared to wt plants. Thus, deficiency in XRN4 function leads to production of pleiotropic morphological defects. These observations suggested that XRN4 regulates the expression of genes involved in several important developmental programs. 3.2. Defects in XRN4 Result in Hypersensitive Physiological Responses to Auxin The pleiotropic defects observed for xrn4 plants, especially their greater stature, their affected root architecture, and their serrated leaves suggested that these mutants are deficient in the regulation of auxin responses. This hypothesis was also supported by our observation that, in normal axenic growth conditions, ein5-7 and xrn4-3 mutants exhibit a significantly higher frequency of root enrolling (37.3% and 52.2%, respectively) (student t -test, p < 1.2 × 10 −5 , n = 66) than wild-type plants (11.9%) which was similar to that of the hypersensitive auxin mutants mir393b-1 , and thus indicative of defects in auxin-dependent gravitropic responses ( Figure S1 ). To test whether auxin-dependent physiological and developmental responses are affected in xrn4 mutants, we compared the incidence of extreme cotyledon epinasty, typical for hypersensitive auxin response [ 15 , 16 ] in wt, in the two xrn4 alleles xrn4-3 and ein5-7 , and in the ein3-1 mutant, which serves as a control to evaluate indirect effects of ethylene signaling deficiency ( Figure 2 ). When grown on standard medium, a high and significantly greater fraction of xrn4-3 and ein5-7 mutants (>74%; Fischer exact test, p < 3.1 × 10 −8 ) than wt (2%) or ein3-1 (19%) plants exhibited the extreme cotyledon epinasty phenotype typical for hypersensitive response to auxin ( Figure 2 ). Similar to what we observed earlier for miR393-deficient mutants and the siTAARs deficient mutant dcl4-2 [ 15 , 16 ], this incidence was decreased by increasing the concentration of the auxin transport inhibitor NPA (1-N-naphthylphthalamic acid) in the medium. Thus, these observations showed that xrn4 mutants exhibit a hypersensitive response to auxin and that the cotyledon epinasty response to auxin depends on the regulation by XRN4, independently of the ethylene pathway. As an additional test of hypersensitive auxin responses, we compared the inhibition of root elongation typical for response to the synthetic auxin 2,4-D in these organs [ 4 ]. Although the changes were subtler, the root elongation of both xrn4 mutant alleles was slightly more inhibited than that of wt plants at all 2,4-D concentrations tested ( Figure S2 ). The 2,4-D concentration necessary to reach 50% inhibition (RI50) was 12% to 24% lower for xrn4 alleles than for wt. Thus, these observations showed that xrn4 mutants also exhibit an auxin hypersensitive response phenotype in roots. Together with the cotyledon epinasty phenotype, these experiments established that XRN4 is important for proper physiological and developmental auxin-mediated responses. 3.3. Chemical Inhibition of TAAR Function Suppresses Specific xrn4 Phenotypes The xrn4 plants exhibit pleiotropic developmental defects, and at least some of these are hypersensitive auxin responses. To test whether some of the xrn4 phenotypes are directly caused by improper auxin signaling, we suppressed the activity of TAAR proteins with the auxin antagonist PEO-IAA, which blocks auxin signaling by occupying the auxin binding site of TAAR proteins [ 35 ]. Interestingly, a significantly greater fraction of xrn4-3 plants (76%; Fischer exact test, p < 1.8 × 10 −11 ) relative to wt plants (12.5%) showed an extreme cotyledon epinasty phenotype which was gradually decreased by increasing the concentration of PEO-IAA in the medium ( Figure 3 A). Furthermore, 80 µM of PEO-IAA was necessary to observe no significative difference between the xrn4-3 and wt plants. We also measured the effect of PEO-IAA on the incidence of leaf serrations ( Figure 3 B). While the number of serrations, which we measured on the third and fourth leaf, was significantly higher in xrn4 compared to wt plants grown on MS medium, this number was decreased to similar values when 80 µM PEO-IAA was applied. Thus, these experiments demonstrated that the chemical suppression of TAAR activity leads to suppression of some of the developmental and physiological defects of xrn4 mutants. 3.4. XRN4 Regulates the Turn-Over of TAAR Transcripts The molecular function of XRN4, the phenotype displayed by xrn4 plants that could be reverted by a TAAR inhibitor and their hypersensitive auxin responses which were reminiscent to what we previously recorded for mir393b-1 suggested a potential role for XRN4 in the regulation of TAAR transcripts. Thus, to determine whether these hypersensitive auxin responses was the result of improper regulation of TAAR gene expression, we analyzed their steady-state mRNA levels in xrn4 mutants by northern blot. Interestingly, we found that the levels of full-length TIR1 , AFB2, and AFB3 mRNAs was higher in xrn4 mutants than in wt plants ( Figure 4 A). AFB1, as for it, could not be detected using this method. To know if the increase of TAAR transcripts in xrn4 plants can affect the production of siTAARs derived from AFB2 (AFB2 3′D2(+)) ( Figure 4 B), we analyzed the accumulation of AFB2 3′D2(+) in xrn4-3 and xrn4-3/rdr6-14 . Whereas the level of mir393 still remained unchanged in xrn4-3 ( Figure S3 ), we can observe an increase of AFB2 3′D2(+) in xrn4-3 but not in the double mutants xrn4/rdr6 as expected, because the production of AFB2 3′D2(+) is dependent of RDR6. To understand why the increase of siTAARs did not result in a decrease of TAAR transcripts, we analyzed the accumulation of AFB2 and AFB2 3′D2(+) in the xrn4 / rdr6 double mutants. In the xrn4/rdr6 double mutants the level of AFB2 is much higher than in the xrn4 mutants ( Figure 4 C), indicating that XRN4 is important for the control of TAAR transcript and siTAAR levels. The expression of auxin receptor genes of the TIR1 / AFB2 clade is affected in xrn4 mutants. However, whether this effect is direct or indirect, and, whether it is responsible for the hypersensitive auxin responses of xrn4 plants remains to be addressed. To address if the TIR / AFB2 transcripts are targeted directly or indirectly by XRN4, we treated the plants with the transcription inhibitor cordycepin [ 30 ] and we measured the kinetic of TAAR transcripts decay. The signals obtained by northern blot for TIR1 and AFB3 were too weak to provide informative conclusion, however, for AFB2 , the signals for full-length mRNAs decreased faster in wt than in xrn4 plants. Indeed, the half-life of AFB2 transcripts was more than three times longer in xrn4 (340 min) than in wt plants (100 min) ( Figure 4 D). Moreover, we ruled out the possibility that this is due to an increased activity of the AFB2 promoter since the expression pattern of AFB2p:GUS was similar or lower, but not higher, in xrn4 compared to wt plants ( Figure S4 ). Thus, together these observations demonstrated that the increased accumulation of AFB2 mRNAs in xrn4 , and possibly that of other TAAR mRNAs, is directly due to improper decay of these mRNAs. Our experiments identified new targets of XRN4. 3.5. xrn4 Plants Exhibit Hypersensitive Auxin Signaling Responses We previously showed that the auxin-hypersensitive mutants mir393a-1 and mir393b-1 exhibit a decreased basal level of DR5pro:GUS expression and a conversely increased basal level of IAA3pro:GUS , of IAA12pro:GUS, and of HS:AXR3-NT:GUS expression, which we could explain by an increased basal level of AUX/IAA proteins [ 16 ]. To determine whether the auxin-dependent hypersensitive phenotypes of xrn4 arise from similar hypersensitive auxin responses, we analyzed the expression of these reporter genes in xrn4 . While the synthetic primary auxin-responsive gene DR5pro:GUS was expressed in the margins and in the hydathodes of leaves, and in the hypocotyls and in the root tips of wt plants, it was only weakly or not at all expressed in xrn4 mutants ( Figure 5 A), and even after 2,4-D treatment, the induction of DR5pro:GUS was still weaker in xrn4 mutant roots compare to the wt roots ( Figure 5 B). Thus, the hypersensitive auxin signaling responses recorded in xrn4 were even stronger ( Figure 5 A) than those observed in mir393a-1 , mir393b-1, and even mir393ab double mutant plants [ 16 ]. Conversely, the IAA12pro:GUS, which are not detected in wt plants, had much higher basal expression levels in emerging leaves and in the meristematic region of xrn4 mutants ( Figure 5 D). In the case of IAA3pro:GUS, we did not observe a difference between xrn4 and wt plants. However, like in miR393-deficient mutants, the expression of IAA3pro:GUS and IAA12pro:GUS was more rapidly induced in xrn4 compared to wt plants by the synthetic auxin 2,4-D ( Figure 5 C,D). Thus, altogether, these results showed that, like miR393 mutants, xrn4 mutants exhibit strong hypersensitive responses to auxin. To determine whether these hypersensitive auxin responses also rely on an increased basal level of AUX/IAA proteins, we analyzed the rate of AUX/IAA degradation by monitoring the accumulation of the AXR3-NT:GUS protein fusion ( Figure 6 ) [ 16 ]. After induction of the HSpro:AXR3-NT:GUS gene for two hours at 37 °C ( Figure 6 ), the AXR3-NT:GUS protein was stable in the roots of xrn4 and accumulated to a level similar to that observed in mir393b-1, while it could not be detected in wt plants ( Figure 6 ) [ 16 ]. Moreover, the two mutants occasionally exhibited ectopic expression of AXR3-NT:GUS in cotyledons and leaves ( Figure 6 ). These observations showed that xrn4-3 plants are also unable to properly degrade AUX/IAA proteins under normal growth conditions. To test whether these hypersensitive auxin responses were due to increased basal levels of AUX/IAA proteins as well, we treated the plants with 2,4-D for 4 h before inducing the HSpro:AXR3-NT:GUS gene. As we anticipated, chasing the high level of AUX/IAA proteins by inducing their degradation with high levels of auxin led to a restoration of the proper degradation of the AXR3-NT:GUS protein ( Figure 6 ). Thus, altogether, these experiments suggest that xrn4 , like miR393-deficient plants, likely accumulate high basal levels of endogenous AUX/IAA proteins. More importantly, these experiments demonstrated that the hypersensitive auxin responses exhibited by xrn4 are comparable and stronger than that exhibited by miR393-deficient mutants and that XRN4 is required to ensure the timely degradation of AUX/IAA proteins and to generate reliable auxin signaling outputs. 4. Discussion We have shown here that the 5′-3′ exoribonuclease XRN4 is a component of the auxin signaling pathway and that this function is achieved through a mechanism involving controlled degradation of TAAR transcripts. The Arabidopsis family of 5′-3′ exonuclease comprises 3 members, only one of which is localized in the cytoplasm and can potentially be involved in mature mRNA turn-over. XRN4 had been implicated in the degradation of 3′ RNA fragments generated upon microRNA-guided cleavages. Rymarquis and colleagues have shown that special features comprised within the 150 nucleotides downstream of the miRNA-binding site are necessary and sufficient for degradation of the 3′ cleavage fragments by XRN4 [ 25 ]. Their bioinformatic analyses also proposed that the basis for XRN4 selectivity might reside at least partially in the presence of hexameric nucleotide motifs. However, none of the xrn4-enriched transcripts used for the analysis have yet been shown to be directly degraded. It is therefore possible that these hexameric motifs rather represent sequences used by other proteins directly or indirectly regulated by XRN4. Similarly, the role of XRN4 in the ethylene signaling pathway occurs by indirectly controlling the mRNA level of EBF1 and EBF2. Because ethylene and auxin pathways are subjected to complex cross-talks at the level of their synthesis and likely at the level of their signaling, it is possible that the effects observed on EBFs are an indirect consequence of direct TAAR regulation. However, this hypothesis remains to be demonstrated. We have shown that the mRNAs of AFB2, and presumably those of the other TAARs, are directly degraded by XRN4. However, the basis for this selectivity or the underlying mechanism remain to be determined. Although the mechanism involved is unknown, we believe that it is highly regulated and specific for selected full-length transcripts. Indeed, accumulation of TAAR transcripts in the xrn4 mutants leads to hypersensitive responses to auxin and developmental defects. Studies by Gregory and colleagues have used deep sequencing approaches to identify Arabidopsis transcripts which might be decapped and degraded by XRN4 [ 36 ]. The experimental validation of at least some of these hypothetical targets will help determining the molecular determinants important for selection by XRN4. Of course, we also expect that the TAAR transcripts are decapped before degradation. Martinez de Alba and colleagues have shown that XRN4 is co-localized with decapping proteins such as decapping (DCP) and varicose (VCS) in the P-bodies [ 37 ]. Like in animals, where XRN1 interacts with DCP1, selection of TAARs for degradation by XRN4 should depend on a specific interaction with a decapping protein [ 38 ]. Martinez de Alba and colleagues have also shown that decapping prevents RDR6-dependent production of small RNAs. RDR6 is localized in siRNA bodies, which are themselves closely linked with the P-bodies, indicating a strong interaction between RNA turnover and RNA silencing. Thus, we can speculate that XRN4 could modulate the quantity of the matrix available for the production and amplification of siTAARs necessary for the TAARs silencing, and so to ensure an appropriate auxin response. We anticipate that siTAARs may also act as non-cells autonomously. Indeed, the pathway that we have identified might be responsible for the generation of certain auxin signaling maxima important for initiation of lateral organ formation [ 39 , 40 ]. Indeed, considering that XRN4 would not be expressed in a given cell or cell group, this would lead to the accumulation of high levels of TAAR transcripts in these cells and to the production of high levels of siTAARs. These would create auxin signaling maxima by subsequently moving and silencing TAAR transcripts in the surrounding cells. Importantly, some of the phenotypic defects observed in XRN4, like the perturbed phyllotaxis characterized by the stochastic production of flowers on the stems or the high degree of leaf serration, strongly support our model [ 41 ] ( Figure 1 ). Our work reveals that TAAR mRNA are targets of XRN4 and demonstrates that their regulation by XRN4 is necessary for the proper auxin response and plant development. Supplementary Materials The following are available online at https://www.mdpi.com/2073-4425/9/12/638/s1 , Figure S1: miR393b-1 and xrn4 mutants exhibit root enrolling phenotype typical for auxin-dependent gravitropy defects, Figure S2: Both ein5-7 and xrn4-3 mutants exhibit hypersensitive auxin-induced root growth inhibition, Figure S3: Level of mir393 remains unchanged in xrn4-3 , Figure S4: Expression of the AFB2 promoter in xrn4-3 . Author Contributions D.W. performed the experiments and analyzed the data. D.W. designed the research. E.B. and D.W. wrote the paper. Funding This work was supported by the Swiss National Science Foundation (Ambizione individual research grants PZ00P3_126329 and PZ00P3_142106 to Franck Vazquez) and by the EPICENTER ConnecTalent grant of the Pays de la Loire (E.B.). Acknowledgments We thank Franck Vazquez, who initiated this work, and for his constant support. The authors thank NASC for providing seeds of xrn4-3 mutants (N014209), Thomas Potuschak for seeds of ein5-7 mutants, Miltos Tsiantis for seeds of DR5pro:GUS line, Mark Estelle for seeds of AFB2pro:GUS line, and Ken-ichiro Hayashi for providing samples of PEO-IAA and auxinole. We thank the organizers and participants of the Auxin’2012 meeting in Hawai’i for informative talks and discussions. We thank Thomas Boller and Christian Körner for providing laboratory space and facilities at the Botanical Institute of the University of Basel. Conflicts of Interest The authors declare no conflict of interest. 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See Table 1 for quantifications. Figure 1. The xrn4 mutants exhibit pleiotropic development defects. For Col-0 and xrn4-3 , the photographs show representative series of rosette leaves and cauline leaves ( A , G ) and magnified views of the 5th leaves ( B , H ), stems with siliques and flowers ( C , I ), terminal inflorescences ( D , J ), closed flower buds ( E , K ), and opened flowers ( F , L ). See Table 1 for quantifications. Figure 2. The xrn4 mutants exhibit extreme auxin-dependent epinasty of cotyledons. The incidence of the auxin-hypersensitive response in populations of Col-0 (open bars), ein3-1 (light grey bars), ein5-7 (dark-grey bars), and xrn4-3 mutants (dark bars). Seedlings ( n > 17 for each condition and genotype) were grown on media containing the concentration of N-1-Naphthylphthalamic Acid (NPA) indicated and harvested four days after germination. The p values (two-tailed Fisher’s exact test) for significant differences towards each other are indicated. Figure 2. The xrn4 mutants exhibit extreme auxin-dependent epinasty of cotyledons. The incidence of the auxin-hypersensitive response in populations of Col-0 (open bars), ein3-1 (light grey bars), ein5-7 (dark-grey bars), and xrn4-3 mutants (dark bars). Seedlings ( n > 17 for each condition and genotype) were grown on media containing the concentration of N-1-Naphthylphthalamic Acid (NPA) indicated and harvested four days after germination. The p values (two-tailed Fisher’s exact test) for significant differences towards each other are indicated. Figure 3. Reversion of xrn4 ’s developmental phenotypes by chemical suppression of TAAR functions. ( A ) The incidence of the auxin-hypersensitive response in populations of Col-0 (open bars); xrn4-3 (solid bars) seedlings grown on media containing the concentration of the auxin antagonist PEO-IAA (alpha-(phenylethyl-2-oxo)-IAA) indicated. The p values (two-sided Fisher exact test) for significant differences between pairs is indicated; no significant (NS), p > 0.05. ( B ) The mean number of serrations per leaf in populations of Col-0 (open bars) and xrn4-3 (solid bars) plantlets grown on media supplemented (+) or (−) with 80 μM of the auxin antagonist PEO-IAA. The p -values (Student t-test) for significant differences are indicated; NS, p > 0.05. Figure 3. Reversion of xrn4 ’s developmental phenotypes by chemical suppression of TAAR functions. ( A ) The incidence of the auxin-hypersensitive response in populations of Col-0 (open bars); xrn4-3 (solid bars) seedlings grown on media containing the concentration of the auxin antagonist PEO-IAA (alpha-(phenylethyl-2-oxo)-IAA) indicated. The p values (two-sided Fisher exact test) for significant differences between pairs is indicated; no significant (NS), p > 0.05. ( B ) The mean number of serrations per leaf in populations of Col-0 (open bars) and xrn4-3 (solid bars) plantlets grown on media supplemented (+) or (−) with 80 μM of the auxin antagonist PEO-IAA. The p -values (Student t-test) for significant differences are indicated; NS, p > 0.05. Figure 4. XRN4 is required for proper accumulation and turn-over of TAAR messenger RNAs (mRNAs) and siTAARs. ( A ) Comparison of TIR1 , AFB2, and AFB3 mRNA accumulation in Col-0, xrn4-3, and mir393b-1 by Northern blot. Signals detected in tir1-10 , afb2-3, and afb3-5 mutants serve as negative controls; ( B , C ) analysis of AFB 3′D2(+) and AFB2 mRNA accumulation, respectively, in mir393b-1 , Col-0, rdr6-14 , xrn4-1, and xrn4-3/rdr6-14 by RNA-blot hybridization and Northern blot. ( D ) Analysis of AFB2 mRNA decay by Northern blot in Col-0 and xrn4-3 mutants for the time indicated after treatment with the transcription inhibitor cordycepin. The half-life (t1/2) of the AFB2 transcript was determined by normalizing the AFB2 signals to the 25S rRNA signals. Arrows indicate the full-length mRNA and asterisks indicate non-specific signals. Midori Green ® stained 25S rRNAs serve as a loading standard for northern blot and U6 for RNA-Blot hybridization. Figure 4. XRN4 is required for proper accumulation and turn-over of TAAR messenger RNAs (mRNAs) and siTAARs. ( A ) Comparison of TIR1 , AFB2, and AFB3 mRNA accumulation in Col-0, xrn4-3, and mir393b-1 by Northern blot. Signals detected in tir1-10 , afb2-3, and afb3-5 mutants serve as negative controls; ( B , C ) analysis of AFB 3′D2(+) and AFB2 mRNA accumulation, respectively, in mir393b-1 , Col-0, rdr6-14 , xrn4-1, and xrn4-3/rdr6-14 by RNA-blot hybridization and Northern blot. ( D ) Analysis of AFB2 mRNA decay by Northern blot in Col-0 and xrn4-3 mutants for the time indicated after treatment with the transcription inhibitor cordycepin. The half-life (t1/2) of the AFB2 transcript was determined by normalizing the AFB2 signals to the 25S rRNA signals. Arrows indicate the full-length mRNA and asterisks indicate non-specific signals. Midori Green ® stained 25S rRNAs serve as a loading standard for northern blot and U6 for RNA-Blot hybridization. Figure 5. The xrn4 mutant exhibits hypersensitive molecular responses to auxin. ( A ) Typical decrease in the basal expression levels of DR5pro:GUS in leaves, hypocotyl, and roots tips of xrn4-3 compared to wt plants; ( B ) lant treatment with 2,4-D for 4 h induced the expression of DR5pro:GUS more rapidly in wt than in xrn4-3 mutants; ( C , D ) expression levels of IAA3pro:GUS and IAA12pro:GUS in leaves of ein5-7 compared to wt plants. Figure 5. The xrn4 mutant exhibits hypersensitive molecular responses to auxin. ( A ) Typical decrease in the basal expression levels of DR5pro:GUS in leaves, hypocotyl, and roots tips of xrn4-3 compared to wt plants; ( B ) lant treatment with 2,4-D for 4 h induced the expression of DR5pro:GUS more rapidly in wt than in xrn4-3 mutants; ( C , D ) expression levels of IAA3pro:GUS and IAA12pro:GUS in leaves of ein5-7 compared to wt plants. Figure 6. XRN4 is required for proper degradation of AXR3-NT:GUS proteins. Pictures of cotyledons and roots of wt, xrn4-3 and mir393b-1 mutant expressing the HSpro:AXR3-NT:GUS gene. Without treatments, the AXR3-NT:GUS fusion protein is more stable in xrn4-3 and mir393b-1 than in wild-type (wt) plants, and sometimes accumulates ectopically in cotyledons. Clearance of high levels of endogenous AUX/IAA proteins by treatment with 2,4-D for 4 h before heat shock (HS) allowed proper degradation of AXR3-NT:GUS. Figure 6. XRN4 is required for proper degradation of AXR3-NT:GUS proteins. Pictures of cotyledons and roots of wt, xrn4-3 and mir393b-1 mutant expressing the HSpro:AXR3-NT:GUS gene. Without treatments, the AXR3-NT:GUS fusion protein is more stable in xrn4-3 and mir393b-1 than in wild-type (wt) plants, and sometimes accumulates ectopically in cotyledons. Clearance of high levels of endogenous AUX/IAA proteins by treatment with 2,4-D for 4 h before heat shock (HS) allowed proper degradation of AXR3-NT:GUS. Table 1. Comparison of wild type (wt) and xrn4 phenotypes at different stages of plant development. Table 1. Comparison of wild type (wt) and xrn4 phenotypes at different stages of plant development. Col-0 xrn4 p -Value 14 days-old Primary Root Length (mm) 51.3 ± 1.3 61.6 ± 1.4 4.0 × 10 −6 N. Lateral Roots 19.9 ± 1.2 12.8 ± 0.7 1.6 × 10 −5 28 days-old Fresh Weight (mg) 105 ± 10 325 ± 29 4.4 × 10 −7 N. of Serrations on 5th Leaf 0.8 ± 0.2 2.0 ± 0.2 3.1 × 10 −4 N. of Serrations on 7th Leaf 1.3 ± 0.3 3.5 ± 0.2 2.5 × 10 −6 34 days-old Number of Leaves 11.9 ± 0.2 17.4 ± 1.0 1.2 × 10 −5 45 days-old N. of duplicated siliques 0.0 ± 0.0 3.3 ± 0.6 3.1 × 10 −4 N. of aborted siliques 0.1 ± 0.1 0.7 ± 0.2 3.4 × 10 −2 N. of Silique insertions 25.0 ± 1.3 29.3 ± 0.7 2.9 × 10 −3 Internode length (mm) 7.9 ± 0.1 6.3 ± 0.2 2.7 × 10 −6 The values are Mean ± SE (standard error) for N = 10 plants grown in standard long day (LD) conditions. Statistical t -test p -values relative to Col-0 are given. Root measurements were done on vertically grown plantlets. The number of leaves was determined at 34 days just before bolting of the plants. These data are for the ein5-7 mutant allele. Similar values were recorded for the ein5-1 allele. Windels D, Bucher E. The 5′-3′ Exoribonuclease XRN4 Regulates Auxin Response via the Degradation of Auxin Receptor Transcripts. Genes. 2018; 9(12):638. https://doi.org/10.3390/genes9120638 Chicago/Turabian Style Windels, David, and Etienne Bucher. 2018. "The 5′-3′ Exoribonuclease XRN4 Regulates Auxin Response via the Degradation of Auxin Receptor Transcripts" Genes9, no. 12: 638. https://doi.org/10.3390/genes9120638 Windels D, Bucher E. The 5′-3′ Exoribonuclease XRN4 Regulates Auxin Response via the Degradation of Auxin Receptor Transcripts. Genes. 2018; 9(12):638. https://doi.org/10.3390/genes9120638 Chicago/Turabian Style Windels, David, and Etienne Bucher. 2018. "The 5′-3′ Exoribonuclease XRN4 Regulates Auxin Response via the Degradation of Auxin Receptor Transcripts" Genes9, no. 12: 638. https://doi.org/10.3390/genes9120638
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(PDF) Drosophihla topoisomerase I: Isolation, purificatioann and characterization PDF | We have purified and characterized topoisomerase I from Drosophila melanogasts. The molecular weight of the enzyme is 135,000; 100,000, 90,000,... | Find, read and cite all the research you need on ResearchGate Drosophihla topoisomerase I: Isolation, purificatioann and characterization December 1982 Nucleic Acids Research 10(21) DOI: 10.1093/nar/10.21.6945 Abstract and Figures We have purified and characterized topoisomerase I from Drosophila melanogasts. The molecular weight of the enzyme is 135,000; 100,000, 90,000, and 65,000 molecular weight products result from degradation of the enzyme. The enzyme relaxes both positive and negative supercoiled DNA. M++ is not absolutely required, but stimulates the enzymatic activity considerably. . Purification of topoisomerase 1 from Drosophila eggs (100 gms) … a). Isoelectric focusing of topoiomerase I. 20 ug each of myoglob in, carbonic anhydrase and bovine serum albumin (Sigma) with isoelectric points of 8.3, 5.9 and 4.9 respectively were used as standards (a). Approximately 1 vg of enzyme was dialyzed extensively against 30 mM potassium phosphate, pH 7.1 and applied in lane (b). Fig. 3(b). Topoisomerase activity from individual segments of agarose gel in lane (b) of Fig. 3(a). Using protein markers as top and bottom of the gel the agarose strip was cut into eight pieces followed by elution and renaturation as described in the text. Lane 4 corresponds to the enzyme band. … a). Formation of the covalent complex between denatured 32P-labelled PM2 DNA and Drosophila topoisomerase I. The sample was prepared as described in Materials and Methods, and run on an SDS gel with 5% acrylamide using 0.075 M sodium phosphate buffer, pH 7, with 0.1% SDS. The resultant … Figures - uploaded by Yuk-Ching Tse-Dinh 2.3+ billion citations Join for free ... Several eukaryotic type I topoisomerases have been characterized including enzymes encoded by some viruses that infect eukaryotes (12) (13) (14)(15). For example, studies on topoisomerase I from vaccinia virus provided valuable insights into the structure-function relationships and the mechanism of type I enzymes (15). ... Topoisomerase II from Chlorella virus PBCV-1 - Characterization of the smallest known type II topoisomerase Article Full-text available Mar 2000 Oleg V. Lavrukhin John M. Fortune Thomas G. Wood R. Stephen Lloyd Type II topoisomerases, a family of enzymes that govern topological DNA interconversions, are essential to many cellular processes in eukaryotic organisms. Because no data are available about the functions of these enzymes in the replication of viruses that infect eukaryotic hosts, this led us to express and characterize the first topoisomerase II encoded by one of such viruses. Paramecium bursaria chlorella virus 1 (PBCV-1) infects certain chlorella-like green algae and encodes a 120-kDa protein with a similarity to type II topoisomerases. This protein was expressed in Saccharomyces cerevisiae and was highly active in relaxation of both negatively and positively supercoiled plasmid DNA, catenation of plasmid DNA, and decatenation of kinetoplast DNA networks. Its optimal activity was determined, and the omission of Mg2+ or its replacement with other divalent cations abolished DNA relaxation, All activities of the recombinant enzyme were ATP dependent. Increasing salt concentrations shifted DNA relaxation from a normally processive mechanism to a distributive mode. Thus, even though the PBCV-1 enzyme is considerably smaller than other eukaryotic topoisomerase II enzymes (whose molecular masses are typically 160-180 kDa), it displays all the catalytic properties expected for a type II topoisomerase. View Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II Oct 1991 Paul J. Laybourn James T Kadonaga The relation between chromatin structure and transcriptional activity was examined by in vitro transcription analysis of chromatin reconstituted in the absence or presence of histone H1. To maintain well-defined template DNA, purified components were used in the reconstitution of chromatin. Reconstitution of nucleosomal cores to an average density of 1 nucleosome per 200 base pairs of DNA resulted in a mild reduction of basal RNA polymerase II transcription to 25 to 50 percent of that obtained with naked DNA templates. This nucleosome-mediated repression was due to nucleosomal cores located at the RNA start site and could not be counteracted by the sequence-specific transcription activators Sp1 and GAL4-VP16. When H1 was incorporated into the chromatin at 0.5 to 1.0 molecule per nucleosome (200 base pairs of DNA), RNA synthesis was reduced to 1 to 4 percent of that observed with chromatin containing only nucleosomal cores, and this H1-mediated repression could be counteracted by the addition of Sp1 or GAL4-VP16 (antirepression). With naked DNA templates, transcription was increased by a factor of 3 and 8 by Sp1 and GAL4-VP-16, respectively (true activation). With H1-repressed chromatin templates, however, the magnitude of transcriptional activation mediated by Sp1 and GAL4-VP16 was 90 and more than 200 times higher, respectively, because of the combined effects of true activation and antirepression. The data provide direct biochemical evidence that support and clarify previously proposed models in which there is depletion or reconfiguration of nucleosomal cores and histone H1 at the promoter regions of active genes. Microinjection of Anti-Topoisomerase I Immunoglobulin G Into Nuclei of Chironomus Tentans Salivary Gland Cells Leads tO Blockage of Transcription Elongation Dec 1987 E Egyházi Egon Durban Purified anti-topoisomerase I immunoglobulin G (IgG) was microinjected into nuclei of Chironomus tentans salivary gland cells, and the effect on DNA transcription was investigated. Synthesis of nucleolar preribosomal 38S RNA by RNA polymerase I and of chromosomal Balbiani ring RNA by RNA polymerase II was inhibited by about 80%. The inhibitory action of anti-topoisomerase I IgG could be reversed by the addition of exogenous topoisomerase I. Anti-topoisomerase I IgG had less effect on RNA polymerase II-promoted activity of other less efficiently transcribing heterogeneous nuclear RNA genes. The pattern of inhibition of growing nascent Balbiani ring chains indicated that the transcriptional process was interrupted at the level of chain elongation. The highly decondensed state of active Balbiani ring chromatin, however, remained unaffected after injection of topoisomerase I antibodies. These data are consistent with the interpretation that topoisomerase I is an essential component in the transcriptional process but not in the maintenance of the decondensed state of active chromatin. Localization of Specific Topoisomerase I Interactions within the Transcribed Region of Active Heat Shock Genes by Using the Inhibitor Camptothecin Article Jan 1987 David S. Gilmour Sarah C. R. Elgin Camptothecin stabilizes the topoisomerase I-DNA covalent intermediate that forms during the relaxation of torsionally strained DNA. By mapping the position of the resultant DNA nicks, we analyzed the distribution of the covalent intermediates formed on heat shock genes in cultured Drosophila melanogaster cells. Topoisomerase I was found to interact with the transcriptionally active genes hsp22, hsp23, hsp26, and hsp28 after heat shock but not with the inactive genes before heat shock. The interaction occurred predominantly within the transcribed region, with specific sites occurring on both the transcribed and nontranscribed strands of the DNA. Little interaction was seen with nontranscribed flanking sequences. Camptothecin only partially inhibited transcription of the hsp28 gene during heat shock, causing a reduced level of transcripts which were nonetheless full length. Topoisomerase I also interacted with the DNA throughout the transcriptionally active hsp83 gene, including an intron, in both heat-shocked and non-heat-shocked cells. The results point to a dynamic set of interactions at the active locus.
https://www.researchgate.net/publication/31290084_Drosophihla_topoisomerase_I_Isolation_purificatioann_and_characterization
India grapples with second wave of COVID-19 - The Lancet Microbe India grapples with second wave of COVID-19 Udani Samarasekera Open Access Published: June, 2021 DOI: https://doi.org/10.1016/S2666-5247(21)00123-3 India's devastating second wave of COVID-19 has overwhelmed its health system and the country. In several cities and states, oxygen supplies have been critical, hospitals have turned patients away, and crematoriums have run out of space. As of May 18, India had reported more than 26·4 million confirmed cases and over 274 000 deaths from COVID-19. The country's surge in cases started in mid-March 2021 and rose rapidly in April. After 10 consecutive days of recording more than 300 000 new infections, on May 1, India reported just over 400 000 new COVID-19 cases in a single day. The country had been lulled into a false sense of security by low COVID-19 case numbers in February. “Functions, marriages that had been delayed for a year were suddenly held day, after day, after day”, Anurag Agrawal, Director of the CSIR Institute of Genomics and Integrative Biology (New Delhi, India) told The Lancet Microbe . Large public festivals and election rallies also went ahead, attended mostly by people not wearing masks or physically distancing. “Laxity was clearly increased all over the country at every level because there was a feeling of getting on with life”, said Agrawal. Variants of SARS-CoV-2 are also probably contributing to the second wave. In late March, the Indian health ministry announced that a new variant, now known as B.1.617, had been identified in the state of Maharashtra. B.1.617 and the variant first identified in the UK, B.1.1.7, are linked to the surge in cases, said Agrawal: “March was a time of B.1.1.7 dominating in India and April the time when B.1.617 really started to rise…From India's point of view, B.1.617 is a variant of concern.” Andrew Rambaut, professor of Molecular Evolution at University of Edinburgh (UK) and a co-investigator in COVID-19 Genomics UK (COG-UK), said that three mutations in B.1.617—causing substitutions E484Q, L452R, and P681R—are worrying. Three global variants of concern, including those first reported in Brazil (P.1 variant) and South Africa (B.1.351 variant), have substitutions at position 484, but these variants contain E484K. E484Q meanwhile has been “shown to have reduced neutralisation by some but not all convalescent plasma samples from people who have had natural infection with SARS-CoV-2 using an experimental system”, wrote Sharon Peacock, Director of COG-UK, and Professor of Public Health and Microbiology, University of Cambridge, UK, in a UK Science Media Centre statement on April 19. L452R is present in several variants of interest, including B.1.429, which is linked to COVID-19 outbreaks in California. “This mutation has been associated with weaker neutralisation of the virus by convalescent plasma from people who have been infected with SARS-CoV-2”, noted Peacock. Agrawal said that on the basis of data from the USA on L452R and the presence of E484Q, Indian scientists thought “moderate increased transmissibility” might occur, “not highly increased transmissibility as we really saw in April”. As for the P681R substitution, it “is located adjacent to the furin cleavage site of the spike protein, which could mean a change in spike protein processing or other changes in biology”, said Peacock. Rambaut noted that all three sublineages of B.1.617 have the P681R mutation. WHO's epidemiological update on April 27 noted that multiple other variants are also circulating in India. However, “preliminary modelling by WHO based on sequences submitted to [global database] GISAID suggest that B.1.617 has a higher growth rate than other circulating variants in India, suggesting potential increased transmissibility, with other co-circulating variants also demonstrating increased transmissibility.” Rambaut cautioned against attributing India's second wave to a single variant: “It's very premature to say that any one of these variants is the predominant reason for the surge. The fact that multiple variants are seen to be going to quite high prevalence possibly indicates a more complex picture than simply a new transmissible variant.” Another factor behind the crisis in India has been its struggle to immunise its large population against SARS-CoV-2. India launched its vaccination drive in January, 2021, with a focus on vaccinating frontline workers and adults older than 45 years. On May 1, all adults older than 18 years became eligible for vaccination. During India's first wave of COVID-19, “young people were simply not getting infected or having much of a severe disease at all” but that is “not what we are seeing this time”, said Agrawal. Vaccine supply has been an issue, with several states reporting shortages of COVID-19 vaccines in early May. As of May 3, just over 9% of India's 1·4 billion population had one dose of a COVID-19 vaccine and only 2% were fully vaccinated. The Serum Institute of India, the world's largest vaccine manufacturer, is set to deliver 220 million doses of Covishield, a version of Oxford–AstraZeneca's COVID-19 vaccine, to India's federal and state governments over the next few months. Still, that amount will only cover 8% of the country's population. Article info Publication history Identification
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(21)00123-3/fulltext
Porsche Newsroom & Notas de Prensa: Porsche extends electric sports car model range with the Taycan 4S - Porsche América Latina Sala de prensa La sala de prensa de Porsche es un servicio proporcionado por Porsche Communication para periodistas, blogueros y multiplicadores. www.newsroom.porsche.com Esta sección contiene una lista completa de nuestras notas de prensa. Current Porsche AG Press releases Porsche extends electric sports car model range with the Taycan 4S New entry-level model with two battery sizes and a range of up to 463 kilometres according to WLTP Stuttgart . It was only in September that the new electric sports car from Porsche celebrated its high-profile premiere on three continents simultaneously. Now, the company is already presenting the third version of the sports saloon with the Taycan 4S. The new model is available with two battery sizes and delivers with the Performance battery up to 390 kW (530 PS) or with the Performance battery Plus up to 420 kW (571 PS). Following the Taycan Turbo S and the Taycan Turbo , the Taycan 4S is therefore the new entry-level model in the series. A single-deck Performance battery with a total capacity of 79.2 kWh comes as standard. The two-deck Performance battery Plus familiar from the Taycan Turbo S and Taycan Turbo is optionally available. The total capacity here is 93.4 kWh. The power output and range therefore vary correspondingly: with the Performance battery, the Taycan 4S generates up to 390 kW (530 PS) overboost power output. Equipped with the Performance battery Plus, it delivers up to 420 kW (571 PS). In both variants, the Taycan 4S accelerates from a standing start to 100 km/h in 4.0 seconds. The top speed is also 250 km/h in both cases. The range is up to 407 kilometres with the Performance battery and up to 463 kilometres with the Performance battery Plus (in accordance with WLTP in each case) – the highest value of the current Taycan range. The maximum charging capacity (peak) is 225 kW (Performance battery) or 270 kW (Performance battery Plus). Innovative drive machines and dynamic performance Breathtaking acceleration, tractive power typical of sports cars and outstanding continuously available power – the new model 4S also features these strengths of the Taycan . The permanently excited synchronous machine on the rear axle has an active length of 130 millimetres and is therefore exactly 80 millimetres shorter than the corresponding drive component on the Taycan Turbo S and Taycan Turbo . The pulse-controlled inverter used on the front axle in the Taycan 4S operates with up to 300 amps, and the inverter on the rear axle with up to 600 amps. With two permanently excited synchronous machines on the front and rear axles, in other words all-wheel drive, as well as a two-speed transmission on the rear axle, the drive architecture comprises the same main technical highlights as on its model brothers. The same also applies to the intelligent charging management and exemplary aerodynamics. With a cd value from 0.22, the aerodynamics makes a significant contribution to low energy consumption and thus long range. The clear, puristic exterior design with Porsche DNA is also typical for the Taycan , as is the unique interior design with wide display band. Puristic exterior design with PorscheDNA With its clear, puristic design, the Taycan signals the beginning of a new era. At the same time, it retains the unmistakable Porsche design DNA. From the front, it looks particularly wide and flat with highly contoured wings. The silhouette is shaped by the sporty roof line sloping downward to the rear. The highly sculpted side sections are also characteristic. The sleek cabin, the drawn-in rear C-pillar and the pronounced shoulders of the wings result in a sharply emphasised rear, typical of the brand. There are also innovative elements such as the glass-effect Porsche logo, which has been integrated into the light bar at the rear. Distinguishing features of the Taycan 4S compared with the Turbo and Turbo S include the aerodynamically optimised 19-inch Taycan S Aero wheels and the red-painted brake callipers. The front apron with new geometry, side sills and rear diffuser in black ensure further visual differentiation. LED headlights including Porsche Dynamic Light System Plus (PDLS Plus) are equipped as standard. Unique interior design with a wide display band The cockpit also signals the start of a new era with its clear structure and completely new architecture. The free-standing, curved instrument cluster forms the highest point on the dashboard. This places a clear focus on the driver axis. A central 10.9-inch infotainment display and an optional passenger display are combined to form an integrated glass band in a black-panel look. As standard, the Taycan 4S comes with a partial leather interior as well as front comfort seats with eight-way electrical adjustment. With the Taycan , Porsche offers an entirely leather-free interior for the first time. Interiors made from innovative recycled materials underscore the sustainable concept of the electric sports car. Centrally networked chassis systems Porsche uses a centrally networked control system for the Taycan chassis. The integrated Porsche 4D Chassis Control analyses and synchronises all chassis systems in real time. As standard, the Taycan 4S features adaptive air suspension with three-chamber technology including electronic damper control PASM ( Porsche Active Suspension Management). The Taycan 4S has six-piston fixed-calliper brakes on the front axle with internally vented cast iron brake discs. The brake disc diameter is 360 millimetres on the front axle and 358 millimetres on the rear axle. Four-piston brakes are used on the rear axle. The brake callipers of the brake system are painted red. The Taycan 4S can be ordered immediately and will arrive in European dealerships in January 2020. Prices in Germany start at 105,607 euros – including VAT and country-specific equipment. Further information, film and photo material in the Porsche Newsroom: newsroom.porsche.com The consumption and CO 2 emission values were calculated according to the new Worldwide Harmonised Light Vehicle Test Procedure (WLTP). The NEDC values derived from this must continue to be specified for the time being. These values cannot be compared with the values calculated on the basis of the previously used NEDC test. Further information on the official fuel consumption and official, specific CO 2 emissions of new passenger cars is available in the publication entitled “Guide on the fuel economy, CO 2 emissions and power consumption of all new passenger car models offered for sale on the German market”, which is available free of charge from all sales outlets and from Deutsche Automobil Treuhand GmbH (DAT). Taycan 4S with Performance battery: combined power consumption 24.6 kWh/100 km; combined CO 2 emissions 0 g/km Taycan 4S with Performance battery Plus: combined power consumption 25.6 kWh/100 km; combined CO 2 emissions 0 g/km Further information and pictures for journalists and media representatives can be found on the Porsche press database at http://presse.porsche.de/ .
https://www.porsche.com/latin-america-es/aboutporsche/pressreleases/?lang=none&pool=international-de&id=565834
Closed-Loop Fluid Administration System Using Hemodynamic Monitors - Full Text View - ClinicalTrials.gov Closed-Loop Fluid Administration System Using Hemodynamic Monitors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT02020863 Recruitment Status : Completed First Posted : December 25, 2013 Results First Posted : May 27, 2016 Last Update Posted : May 27, 2016 Sponsor: University of California, Irvine Information provided by (Responsible Party): Maxime Cannesson, University of California, Irvine Study Details Study Description Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Brief Summary: The purpose of this study is to evaluate the feasibility of a closed-loop (automated) fluid administration system to deliver fluids using feedback from standard operating room hemodynamic monitors. In standard anesthesia care the rate of IV fluid administration to the patient is determined by the anesthesiologist caring for the patient. In this study protocol, the rate of fluid administration will be determined instead by the closed-loop (automated) control system under the supervision of the anesthesiologist. The system will independently decide when to give fluid and at what rate; the supervising anesthesiologist will monitor the system to ensure appropriate volumes are being delivered and to intervene if necessary. Condition or disease Intervention/treatment Phase Intraoperative Volume Status Postoperative Complications Device: Closed Loop Not Applicable Detailed Description: In our protocol we will test the hypothesis that closed-loop fluid administration can maintain higher cardiac stroke volume (shown to improve patient outcomes after surgery) than anesthesiologist management. We have shown this to be the case in multiple simulation studies and in-vivo animal studies, but not yet experimentally in a clinical setting. Investigators will recruit their patients from the surgical record that that require cardiac output monitoring undergoing surgery and require mechanical ventilation and consent to participate in the study will be included in the study. They will receive standard patient care in that in no way will their anesthetic or surgical procedure will be altered as part of the study, with the exception of fluid administration. Fluids are usually given to a patient based on the physician's discretion. As part of the study patients will receive fluid management via a closed loop (automated) system that will use an infusion pump (Q-Core) and a controller (a computer run index and algorithm developed by Sironis) to make frequent, regular and accurate adjustments to the amount of fluid the patient receives using feedback from standard operating room monitors at UCI). Data from this study will be retrospectively compared to subjects case matched to evaluate differences in cardiac output, total fluid given, and patient outcomes. Study Design Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Layout table for study information Study Type : Interventional  (Clinical Trial) Actual Enrollment : 40 participants Allocation: N/A Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Closed-Loop Fluid Administration System Using Hemodynamic Monitors Study Start Date : November 2012 Actual Primary Completion Date : May 2014 Actual Study Completion Date : May 2014 Arms and Interventions Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Arm Intervention/treatment Experimental: Closed Loop Study patients will receive a baseline crystalloid infusion of 3 cc/kg/hr and all additional fluid management will be performed via a closed loop (automated) system that will determine rate, amount, and timing of fluid administration. Device: Closed Loop Fluid management in the closed loop group will be performed via a closed loop (automated) system that will use an infusion pump (Q-Core) and a controller (a computer run index and algorithm developed by Sironis) to make frequent, regular and accurate adjustments to the amount of fluid the patient receives using feedback from standard operating room monitors. Outcome Measures Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Primary Outcome Measures : Fluid Status During Surgery [ Time Frame: Duration of Surgery, up to 8 hours ] The primary outcome between groups is preload independence, defined as % case time where Stroke Volume Variation (SVV) is ≤12%. Eligibility Criteria Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Layout table for eligibility information Ages Eligible for Study: 18 Years and older   (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Adult subjects (over the age of 18) Subjects undergoing elective major, abdominal surgery Subjects requiring general anesthesia and mechanical ventilation Subjects requiring cardiac output monitoring and an arterial line Exclusion Criteria: Subjects under 18 years of age Subjects not undergoing surgery Subjects not requiring general anesthesia or mechanical ventilation Subjects not requiring cardiac output monitoring or an arterial line Subjects who are pregnant Subjects without the capacity to give informed consent Publications: Rinehart J, Liu N, Alexander B, Cannesson M. Review article: closed-loop systems in anesthesia: is there a potential for closed-loop fluid management and hemodynamic optimization? Anesth Analg. 2012 Jan;114(1):130-43. doi: 10.1213/ANE.0b013e318230e9e0. Epub 2011 Sep 29. Bednarski P, Siclari F, Voigt A, Demertzis S, Lau G. Use of a computerized closed-loop sodium nitroprusside titration system for antihypertensive treatment after open heart surgery. Crit Care Med. 1990 Oct;18(10):1061-5. doi: 10.1097/00003246-199010000-00002. Colvin JR, Kenny GN. Development and evaluation of a dual-pump microcomputer-based closed-loop arterial pressure control system. Int J Clin Monit Comput. 1989 Jan;6(1):31-5. doi: 10.1007/BF01723370. Blankenship HB, Wallace FD, Pacifico AD. Clinical application of closed-loop postoperative autotransfusion. Med Prog Technol. 1990 May;16(1-2):89-93. Bowman RJ, Westenskow DR. A microcomputer-based fluid infusion system for the resuscitation of burn patients. IEEE Trans Biomed Eng. 1981 Jun;28(6):475-9. doi: 10.1109/TBME.1981.324822. No abstract available. Chaisson NF, Kirschner RA, Deyo DJ, Lopez JA, Prough DS, Kramer GC. Near-infrared spectroscopy-guided closed-loop resuscitation of hemorrhage. J Trauma. 2003 May;54(5 Suppl):S183-92. doi: 10.1097/01.TA.0000064508.11512.28. DeBey RK, Westenskow DR, Jordan WS, McJames SW. A urine based control system for fluid infusion. Biomed Sci Instrum. 1987;23:195-8. No abstract available. Rinehart J, Alexander B, Le Manach Y, Hofer C, Tavernier B, Kain ZN, Cannesson M. Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: an in silico simulation study. Crit Care. 2011;15(6):R278. doi: 10.1186/cc10562. Epub 2011 Nov 23. Rinehart J, Lee C, Cannesson M, Dumont G. Closed-loop fluid resuscitation: robustness against weight and cardiac contractility variations. Anesth Analg. 2013 Nov;117(5):1110-8. doi: 10.1213/ANE.0b013e3182930050. Rinehart J, Lee C, Canales C, Kong A, Kain Z, Cannesson M. Closed-loop fluid administration compared to anesthesiologist management for hemodynamic optimization and resuscitation during surgery: an in vivo study. Anesth Analg. 2013 Nov;117(5):1119-29. doi: 10.1213/ANE.0b013e3182937d61. Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds RM, Bennett ED. Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. Crit Care. 2005;9(6):R687-93. doi: 10.1186/cc3887. Epub 2005 Nov 8. Forget P, Lois F, de Kock M. Goal-directed fluid management based on the pulse oximeter-derived pleth variability index reduces lactate levels and improves fluid management. Anesth Analg. 2010 Oct;111(4):910-4. doi: 10.1213/ANE.0b013e3181eb624f. Epub 2010 Aug 12. Rinehart J, Chung E, Canales C, Cannesson M. Intraoperative stroke volume optimization using stroke volume, arterial pressure, and heart rate: closed-loop (learning intravenous resuscitator) versus anesthesiologists. J Cardiothorac Vasc Anesth. 2012 Oct;26(5):933-9. doi: 10.1053/j.jvca.2012.05.015. Epub 2012 Jul 12. Rinehart J, Lilot M, Lee C, Joosten A, Huynh T, Canales C, Imagawa D, Demirjian A, Cannesson M. Closed-loop assisted versus manual goal-directed fluid therapy during high-risk abdominal surgery: a case-control study with propensity matching. Crit Care. 2015 Mar 19;19(1):94. doi: 10.1186/s13054-015-0827-7. Joosten A, Huynh T, Suehiro K, Canales C, Cannesson M, Rinehart J. Goal-Directed fluid therapy with closed-loop assistance during moderate risk surgery using noninvasive cardiac output monitoring: A pilot study. Br J Anaesth. 2015 Jun;114(6):886-92. doi: 10.1093/bja/aev002. Epub 2015 Feb 17.
https://clinicaltrials.gov/show/NCT02020863
Children’s Perceptions of Sibling Conflict During Middle Childhood: Issues and Sibling (Dis)similarity | Request PDF Request PDF | Children’s Perceptions of Sibling Conflict During Middle Childhood: Issues and Sibling (Dis)similarity | This study focused on the content (rather than the frequency) of sibling conflict, conflict initiation, and conflict resolution during middle... | Find, read and cite all the research you need on ResearchGate Children’s Perceptions of Sibling Conflict During Middle Childhood: Issues and Sibling (Dis)similarity December 2001 Review of Social Development 9(2):173 - 190 DOI: 10.1111/1467-9507.00118 Authors: Afsoon Eftekhari Abstract This study focused on the content (rather than the frequency) of sibling conflict, conflict initiation, and conflict resolution during middle childhood. Sibling similarity and heritability of children’s perceptions of sibling conflict were also examined. One hundred and eight school-aged sibling pairs were interviewed using a semi-structured interview format (average ages were 11.1 years and 8.2 years, respectively). Children’s responses were coded using 16 categories extracted from the literature and interviews. Results showed that descriptions of disagreements revolved around issues between the siblings (e.g., sharing personal possessions and physical aggression) rather than parental favoritism. Parental intervention, on the other hand, was cited as the most common outcome. Children in the same family rarely mentioned the same issues and only six out of 16 of the topics showed a pattern suggesting heritability. The importance of the school-aged sibling relationship to children’s sense of self, personal rights, and social understanding is discussed. ... For example, sibling cooperation yielded an estimate of 75 %, with this increasing to 85 % for sibling conflict. McGuire et al. (2000) focused their paper on sibling negativity, using a sample of full (biological) siblings and unrelated (adoptive) siblings, rather than twins. The authors reported evidence of a significant environmental contribution towards conflict within these dyads when children's reports were explored. ... ... Much of the existing research exploring SRQ in twins has compared MZ and DZ twins in the absence of a non-twin group (e.g., Penninkilampi-Kerola et al. 2005), or compared twins to non-twins, without considering twin zygosity (e.g., Tancredy and Fraley 2006). With the exception of Reiss et al.'s (2000) work, the BG papers discussed here have also either left out non-twin siblings in their research (e.g., Lemery and Goldsmith 2001), or have recruited biological siblings versus adoptive siblings (e.g., McGuire et al. 2000) . These methodologies make it difficult to confirm, or disconfirm, inclusive fitness or attachment theories when studying sibling relationships. ... ... Also in line with the existing evidence (Lemery and Goldsmith 2001; McGuire et al. 2000; Reiss et al. 2000;Rende et al. 1992), parents tended to rate their children's behaviour towards one another in similar terms, yielding a large shared environmental component. This is indicative of consistency among children within the same family, once genetic similarity has been accounted for. ... Using Twins to Better Understand Sibling Relationships Article Full-text available Katharine M. Mark Alison Pike Rachel M Latham Bonamy R Oliver We compared the nature of the sibling relationship in dyads of varying genetic relatedness, employing a behavioural genetic design to estimate the contribution that genes and the environment have on this familial bond. Two samples were used-the Sisters and Brothers Study consisted of 173 families with two target non-twin children (mean ages = 7.42 and 5.22 years respectively); and the Twins, Family and Behaviour study included 234 families with two target twin children (mean age = 4.70 years). Mothers and fathers reported on their children's relationship with each other, via a postal questionnaire (the Sisters and Brothers Study) or a telephone interview (the Twins, Family and Behaviour study). Contrary to expectations, no mean level differences emerged when monozygotic twin pairs, dizygotic twin pairs, and non-twin pairs were compared on their sibling relationship quality. Behavioural genetic analyses also revealed that the sibling bond was modestly to moderately influenced by the genetic propensities of the children within the dyad, and moderately to substantially influenced by the shared environment common to both siblings. In addition, for sibling negativity, we found evidence of twin-specific environmental influence-dizygotic twins showed more reciprocity than did non-twins. Our findings have repercussions for the broader application of results from future twin-based investigations. ... É possível que disputas sobre direitos e propriedades sejam uma característica única e consistente da relação fraterna, ao menos enquanto ambos os irmãos vivem em casa. Além deste tema, a divisão de tarefas domésticas (Felson, 1983), a agressão física e verbal (McGuire et al., 2000) e o mau humor ou problemas de personalidade dos irmãos foram apontados como temas centrais das disputas (McGuire et al., 2000;Prochaska & Prochaska, 1985). O relato dos irmãos raramente incluiu o relacionamento com os progenitores como fonte de conflito. ... ... É possível que disputas sobre direitos e propriedades sejam uma característica única e consistente da relação fraterna, ao menos enquanto ambos os irmãos vivem em casa. Além deste tema, a divisão de tarefas domésticas (Felson, 1983), a agressão física e verbal (McGuire et al., 2000) e o mau humor ou problemas de personalidade dos irmãos foram apontados como temas centrais das disputas (McGuire et al., 2000; Prochaska & Prochaska, 1985). O relato dos irmãos raramente incluiu o relacionamento com os progenitores como fonte de conflito. ... ... O relato dos irmãos raramente incluiu o relacionamento com os progenitores como fonte de conflito. A luta por ter a atenção e o amor dos progenitores, conflitos envolvendo o tratamento parental diferencial ou comparações, estiveram entre as causas menos frequentes de conflito relatadas pelos irmãos (Felson, 1983; McGuire et al., 2000; Prochaska & Prochaska, 1985). Dunn (1995) corroborou esta perspectiva, ao afirmar que o conflito fraterno possuiria diversas causas, além da rivalidade e do ciúme. ... sibling rivalry ... However, for many families in the modern western world (where our study was conducted), access to resources is adequate if not abundant. Studies focusing on proximate explanations of sibling conflict have suggested that the most common sources of conflict include issues of relative power, selfinterest (sharing personal items), violation of rules, and activities outside the family (McGuire et al., 2000) . Both younger and older siblings' most common complaint is about sharing personal possessions with the least common complaint competition over parental attention from toddlers to adolescents (Campione- Barr & Smetana, 2010;Dunn & Munn, 1985;McGuire et al., 2000). ... ... Studies focusing on proximate explanations of sibling conflict have suggested that the most common sources of conflict include issues of relative power, selfinterest (sharing personal items), violation of rules, and activities outside the family (McGuire et al., 2000). Both younger and older siblings' most common complaint is about sharing personal possessions with the least common complaint competition over parental attention from toddlers to adolescents (Campione- Barr & Smetana, 2010;Dunn & Munn, 1985; McGuire et al., 2000) . ... Good Friends, Better Enemies? The Effects of Sibling Sex, Co-Residence, and Relatedness on Sibling Conflict and Cooperation Dec 2021 Catherine A. Salmon While siblings can be close allies, they can also be significant competitors. They are also family members that are typically with us for most of our lives. Research has raised questions about the factors shaping sibling relationships, and an adaptationist perspective would predict a role for a number of factors including sex, genetic relatedness, and childhood co-residence. Recent work has highlighted sex differences with regard to conflict and emotional closeness, greater conflict among full-siblings than half-siblings, and a role for co-residence in increasing sibling altruism. This study examines levels of both sibling conflict and sibling cooperation as a function of respondent sex, sex of sibling, birth interval (or absolute age difference), co-residence, and relatedness. Results indicate that sibling conflict and cooperation may not be shaped by the same set of factors. Sibling conflict was predicted by own sex, sex of sibling, birth interval, duration of co-residence, and the degree of relatedness. Greater levels of conflict were reported by sisters, those closer in age, those who have co-resided longer, and full-siblings compared to half-siblings. However, sibling prosocialness was only predicted by sex and relatedness with females and full siblings reporting greater levels of sibling prosocialness. More research investigating patterns of conflict and cooperation within families using more ecologically valid cues are necessary to determine whether the two are operating under the same mechanism, sensitive to the same cues, or are, indeed, operating under different mechanisms. ... To date, studies of adolescent siblings' conflict content have only utilized questionnaires (Campione- Barr et al., 2013;Campione-Barr & Smetana, 2010) or standardized interviews (Raffaelli, 1992) about previous sibling conflicts. Studies of younger siblings' conflicts also have used semi-structured or open interviews, as well as observations (McGuire et al., 2000; Recchia & Howe, 2010;Ross et al., 2006;Wilson et al., 2004). Conducting observational studies with adolescent siblings also is important in order to better understand the content of sibling conflict and how the content of conflicts is associated with the quality of conflict discussions and relationship quality. ... ... Finally, future research could examine sibling conflicts over a larger age range. For instance, prior studies on the content of sibling conflicts in early and middle childhood have found that conflicts typically surround sharing, possessions, inappropriate/ irritating behavior, and physical aggression (e.g., McGuire et al., 2000) . Although these topics were present in some of adolescents' conflicts, conflicts involving invasion of the personal domain (more broadly than possessions) appear to be more evident in adolescence than earlier in development (based on comparison of rates across separate studies). ... Differing Domains of Actual Sibling Conflict Discussions and Associations with Conflict Styles and Relationship Quality ... The most commonly cited source of conflict by both older and younger siblings has been the sharing of personal possessions, and the least commonly cited source has been competition over parental attention. This has been a consistent finding in studies conducted with toddlers and preschool-aged siblings (Dunn and Munn 1987;Stenimetz 1977), school-aged siblings (McGuire et al. 2000) , as well as adolescent siblings who noted conflict over personal space and possessions as not only the most frequent source of conflict, but also the most intense one (Campione-Barr and Smetana 2010). Given the consistency of these findings, it has been suggested that sibling conflict may be a process by which children learn their place in the world, learn how to set personal boundaries, and (especially for young adolescents) learn to assert their independence and claim autonomy over their personal choices (McGuire et al. 2000). ... ... This has been a consistent finding in studies conducted with toddlers and preschool-aged siblings (Dunn and Munn 1987;Stenimetz 1977), school-aged siblings (McGuire et al. 2000), as well as adolescent siblings who noted conflict over personal space and possessions as not only the most frequent source of conflict, but also the most intense one (Campione-Barr and Smetana 2010). Given the consistency of these findings, it has been suggested that sibling conflict may be a process by which children learn their place in the world, learn how to set personal boundaries, and (especially for young adolescents) learn to assert their independence and claim autonomy over their personal choices (McGuire et al. 2000) . ... The Evolution of Violence This volume is an interdisciplinary exploration of our understanding of the causes and consequences of violence. Represented in its chapters are noted scholars from a variety of fields including psychology, anthropology, law, and literature. The contributions reflect a broad scope of inquiry and diverse levels of analysis. With an underlying evolutionary theme each of the contributors invoke their separate areas of expertise, offering empirical and theoretical insights to this complex subject. The multi-faceted aspect of the book is meant to engender new perspectives that will synthesize current knowledge and lead to a more nuanced understanding of an ever timely issue in human behavior. Of additional interest, is a foreword written by world renowned psychologist, Steven Pinker, and an afterword by noted evolutionary scholar, Richard Dawkins. © Springer Science+Business Media New York 2014. All rights are reserved. ... Given that younger siblings look up to their older siblings, they may be eager to maintain harmony and engage in shared activities, whereas older siblings may perceive this 36 POWER, CONTROL, AND INFLUENCE IN SIBLING RELATIONSHIPS ACROSS DEVELOPMENT solicitousness as a source of irritation. In contrast, older siblings may be more concerned with issues of autonomy and privacy, especially with increasing age as they focus on extending their boundaries of personal jurisdiction (Helwig, 2006; McGuire, Manke, Eftekhari, & Dunn, 2000) . Furthermore, given older siblings' greater tendency to engage in aggressive conflict actions, self-protective motives may be more salient to younger siblings. ... ... Coding categories were drawn from theory and research pertaining to sibling conflict issues and motivations, as described in the introduction (e.g., McGuire et al., 2000; Recchia et al., 2015;. Categories were subsequently refined based on family members' responses. ... Relative Power in Sibling Relationships Across Adolescence During childhood, older siblings typically hold a more powerful position in their relationship with their younger siblings, but these relationships are thought to become more egalitarian during adolescence as siblings begin to prepare for their relationships as adults and as younger siblings become more socially and cognitively competent. Little is known about relationship factors that may explain this shift in power dynamics, however. The present study therefore examined longitudinal changes in adolescents’ and their siblings’ perceptions of sibling relative power from age 12 to 18 (n = 145 dyads), and examined whether different levels of sibling relationship positivity and negativity, as well as sibling structural variables, indicated different over-time changes in relative power. Multilevel models indicated that adolescents reported significant declines in their siblings’ relative power across adolescence, with older siblings relinquishing the most power over time. However, only siblings with less positively involved relationships reported declines in relative power, suggesting that siblings who maintain highly involved relationships may not become more egalitarian during adolescence. ... Specifically, it has been found that although more siblings are associated with more overall incidents of sibling conflict, fewer siblings are associated with more severe acts of violence (Straus, Gelles, & Steinmetz, 2006). Studies which have investigated proximate explanations of sibling conflict found the most commonly cited sources of conflict (cited by both older and younger siblings) involved issues of relative power, self-interest (e.g., sharing of personal items), violation of rules (e.g., perceived immaturity and inappropriate behavior), as well as interests outside the family (McGuire, Manke, Eftekhari, & Dunn, 2000) . Across different ages from toddlerhood through adolescence, the most commonly cited source of conflict (in terms of both frequency as well as intensity) has been the sharing of personal space and possessions, while the least cited source of conflict has been competition over parental attention (Campione-Barr & Smetana, 2010;Dunn & Munn, 1987;McGuire et al., 2000;Steinmetz, 1977). ... ... Studies which have investigated proximate explanations of sibling conflict found the most commonly cited sources of conflict (cited by both older and younger siblings) involved issues of relative power, self-interest (e.g., sharing of personal items), violation of rules (e.g., perceived immaturity and inappropriate behavior), as well as interests outside the family (McGuire, Manke, Eftekhari, & Dunn, 2000). Across different ages from toddlerhood through adolescence, the most commonly cited source of conflict (in terms of both frequency as well as intensity) has been the sharing of personal space and possessions, while the least cited source of conflict has been competition over parental attention (Campione-Barr & Smetana, 2010;Dunn & Munn, 1987; McGuire et al., 2000; Steinmetz, 1977). ... Sibling Conflict ... Furthermore, behavior and choices were the most frequent source of conflict among television siblings, while physical possessions were the least frequent source. These findings counter real-life conclusions that siblings most often fight over personal property or personal space (Dunn & Munn, 1987; McGuire et al., 2000; Raffaelli, 1997;Ross et al., 2006;Wilson et al., 2004). Real-life siblings also have conflicts surrounding fairness of time with personal possessions and time spent with other family members (McGuire et al., 2000). ... ... These findings counter real-life conclusions that siblings most often fight over personal property or personal space (Dunn & Munn, 1987;McGuire et al., 2000;Raffaelli, 1997;Ross et al., 2006;Wilson et al., 2004). Real-life siblings also have conflicts surrounding fairness of time with personal possessions and time spent with other family members (McGuire et al., 2000) . However, television siblings appear more concerned with helping one another make better choices, rather than arguing over toys or money. ... Women Leaders in Higher Education: Constructing an Active Voice Full-text available Jan 2014 Despite a substantial increase in the number of women with advanced degrees in higher education, women leaders remain underrepresented in top leadership positions. This continued underrepresentation in numbers and status indicates that having more women in the university pipeline is not enough to improve the leadership status of women in higher education. Therefore, a fundamental change is needed in the approach that women take when considering and pursuing leadership positions. This qualitative study proposes that an essential component of this change should be an increase in women’s use of an “active voice” on college campuses. This study investigates how seven successful women leaders in higher education have constructed and implemented an active voice in developing their own leadership skills, and advancing opportunities for future women leaders, despite barriers that traditionally impede leadership attainment for women in higher education. Collectively, the stories of the seven women leaders depict higher education as a complex environment in which women struggle not only for equality, but also for their voices to be heard by both men and women. ... In relation to family size, evidence suggests more siblings are associated with more overall incidents of violence (Straus, Gelles, and Steinmetz 2006). Investigations of proximate explanations have found the most common sources of sibling conflict to involve issues of relative power, selfinterest such as the sharing of personal items, violation of rules (e.g., perceived immaturity and inappropriate behavior), and interests outside the family (McGuire, Manke, Eftekhari, and Dunn 2000) . The most commonly cited source of conflict by both older and younger siblings is the sharing of personal possessions, and the least commonly cited source is competition over parental attention. ... ... The most commonly cited source of conflict by both older and younger siblings is the sharing of personal possessions, and the least commonly cited source is competition over parental attention. This has been a consistent finding in studies conducted with toddlers and preschool-aged siblings (Dunn and Munn 1985;Steinmetz 1977), school-aged siblings (McGuire et al. 2000) , as well as adolescent siblings who noted conflict over personal space and possessions as not only the most frequent source of conflict but also the most intense (Campione-Barr and Smetana 2010). ... The Evolutionary Psychology of Sibling Conflict and Siblicide Our siblings can be our closest allies and yet are often our first rivals. What factors influence the nature of these relationships, and are there certain aspects that make our sib-lings more likely to be a source of conflict rather than solidar-ity? From an adaptationist perspective, sibling conflict should vary in frequency and intensity as a function of degree of relatedness. For example, conflict should be most frequent and intense between non-biological and step-siblings while conflict between full biological siblings should be least frequent and intense with half-sibling conflict being of an intermediate degree. This study examines levels of sibling conflict as a function of sex of participant, sex of sibling, degree of relatedness, and length of co-residence as well as self-reported sources of conflict. Results indicate that genetic relatedness does influence the frequency and intensity of conflict, though the most intense conflict was between non-biological siblings and the least was between half-siblings. ... In relation to family size, evidence suggests more siblings are associated with more overall incidents of violence (Straus, Gelles, & Steinmetz, 2006). Investigations of proximate explanations have found the most common sources of sibling conflict to involve issues of relative power, self-interest such as the sharing of personal items, violation of rules (e.g., perceived immaturity and inappropriate behavior), and interests outside the family (McGuire, Manke, Eftekhari, & Dunn, 2000) . It is interesting that the most commonly cited source of conflict by both older and younger siblings has been the sharing of personal possessions, and the least commonly cited source has been competition over parental attention. ... ... It is interesting that the most commonly cited source of conflict by both older and younger siblings has been the sharing of personal possessions, and the least commonly cited source has been competition over parental attention. This has been a consistent finding in studies conducted with toddlers and preschool aged siblings (Dunn & Munn, 1987;Stenimetz, 1977), school aged siblings (McGuire et al., 2000) , as well as adolescent siblings who noted conflict over personal space and possessions as not only the most frequent source of conflict, but also the most intense (Campione- Barr & Smetana, 2010). ... Evolutionary Perspectives on the Nature of Sibling Conflict: the Impact of Sex, Relatedness, and Co-residence Our siblings can be our closest allies and yet are often our first rivals. What factors influence the nature of these relationships, and are there certain aspects that make our siblings more likely to be a source of conflict rather than solidarity? From an adaptationist perspective, sibling conflict should vary in frequency and intensity as a function of degree of relatedness. For example, conflict should be most frequent and intense between non-biological and step-siblings while conflict between full biological siblings should be least frequent and intense with half-sibling conflict being of an intermediate degree. This study examines levels of sibling conflict as a function of sex of participant, sex of sibling, degree of relatedness, and length of co-residence as well as self-reported sources of conflict. Results indicate that genetic relatedness does influence the frequency and intensity of conflict, though the most intense conflict was between non-biological siblings and the least was between half-siblings. ... The quality of sibling relationships may, however, be affected by a wide range of factors. As young children are learning social skills and self-regulation, while cohabiting in close quarters and sharing possessions, conflict is common (McGuire et al., 2000) . Individual differences in age, gender and personality may lead to more or less friction between siblings (Milevsky, 2021). ... A Randomized Controlled Trial of a Parenting Program to Improve Sibling Relationships Jinny Hong Matthew R. Sanders Although parents of siblings play a crucial role in the development of both the positive and negative aspects of their children’s relationships, relatively few parenting programs specifically target sibling conflict alongside sibling warmth. To bridge this gap, the current study reports the outcomes of a randomized controlled trial evaluating a brief parenting intervention focusing on improving sibling relationships. A total of 74 parents reporting concerns about sibling conflict were randomized to either the Triple P brief discussion group intervention condition (n = 37) or the waitlist control condition (n = 37). Parents were predominately Caucasian, female, from a middle-income background. Parents completed a range of self-report measures examining the quality of the sibling relationship, parenting practices, family functioning, and child emotional and behavioral problems. Across treatment groups, participants showed improvements on almost all measures of sibling conflict, sibling warmth, child emotional and behavioral problems, parenting practices, and parenting confidence. Participants in the treatment group also experienced a greater reduction in the amount of help they wanted to manage sibling warmth, relative to participants in the control group. These results suggest that a low-intensity parenting intervention may only have a small effect on improving sibling relationships. Additional research is needed to determine how to broaden program efficacy for sibling conflict and parental adjustment, for families from diverse levels of income and family composition. Trial registration: ANZCTR 365567. ... While some studies have shown that larger sibships are associated with more sibling conflict (Straus et al., 2006), much of the research in the modern west has taken place in populations where resources are at least adequate if not abundant. In such populations, research suggests the most common sources of sibling conflict include issues of relative power, self-interest (sharing), violations of rules/obligations, and activities outside the family (Campione- Barr & Smetana, 2010; McGuire et al., 2000) . ... Sibling Conflict and Closeness: The Effects of Sex, Number of Siblings, Relatedness, Parental Resemblance and Investment Siblings may be our staunchest supporters as well as our most significant rivals. What factors shape these sibling relationships into ones of conflict versus closeness? Are conflict and closeness shaped by the same factors, occupying opposite ends of the same spectrum? Or are conflict and closeness independent of each other, being shaped by different factors? The current study examined conflict and closeness between siblings as a function of respondent sex; sex of sibling; genetic relatedness; age difference; time spent together; and perceived parental resemblance, investment, and favoritism. Results indicate the factors that shape conflict differ from those that shape closeness, suggesting they are not simply opposite ends of the same spectrum. While genetic relatedness, perceived parental favoritism, and sex of sibling relative to the respondent explained most of the variance in sibling conflict, most of the variance in sibling closeness was explained by time spent with the sibling and perceived sibling resemblance—not genetic relatedness. Furthermore, the factors examined in the study explained much more variance in closeness than in conflict. Future research utilizing within-family designs as well as cross-cultural data will be useful in adding to our understanding of how sibling conflict and closeness are shaped. ... In contrast, boys have been found to have more conflict with their siblings and are more likely to engage in destructive conflict resolution strategies (i.e., physical aggression) (Brody et al., 1985). Boy-boy pairs demonstrate the highest rate of intersibling conflict and aggression, followed by mixed-sex and girl-girl pairs, suggesting that sibling aggression may be higher when the dyad contains a boy (Aguilar et al., 2001;Buhrmester & Furman, 1990;Buist, 2010;Hoffman et al., 2005; McGuire et al., 2000) . ... Do siblings influence one another? Unpacking processes that occur during sibling conflict Sahar Borairi André Plamondon Michelle Rodrigues Jennifer M. Jenkins This study examined the extent to which 205 sibling dyads influenced each other during conflict. Data were collected between 2013 to 2015. The sample included 5.9% Black, 15.1% South Asian, 15.1% East Asian, and 63.8% White children. Older siblings were between 7–13 years old (Female = 109) and younger siblings were 5–9 years old (Female = 99). Siblings' conflict resolution was analyzed using dynamic structural equation modeling. Modeling fluctuations in moment‐to‐moment data (20‐s intervals) allowed for a close approximation of causal influence. Older and younger siblings were found to influence one another. Younger sisters were more constructive than younger brothers, especially in sister–sister dyads. Sibling age gap predicted inertia in older siblings. Socialization processes within sibling relationships are discussed. ... Another important area to explore is examining the influence of body-related parental differential treatment. Specifically, examining whether or not parents differentially encourage their children to diet or exercise or compare their children's appearances is important to study because it may negatively impact individual's body image and lead to negative parentchild and sibling relationships (McGuire et al., 2000; Padilla et al., 2016). Van Diest and Tylka (2010) explain the need to explore caregivers' messages because caregivers' messages may vary by their level of internalization of societal standards and as a result may treat their children differently. ... Negative messages from parents and sisters and Latina college students’ body image shame BODY IMAGE Avelina Rivero Sarah Killoren Gabrielle Kline Nicole Campione-Barr Using the sociocultural model and risk and resilience theory, we examined the moderating role of Latinas’ family relationship quality on the associations between negative eating and weight messages from fathers, mothers, and sisters, and Latinas’ body image shame. Utilizing Amazon Mechanical Turk, we recruited a sample of 195 Latina young adults (Mage = 23.24, range = 18 −25; SD = 1.95; 67.4 % Mexican-origin) who reported retrospectively on negative appearance-related messages from each family member (i.e., fathers, mothers, and sisters), positive (e.g., parental warmth and sibling intimacy) and negative (i.e., parental psychological control and sibling negativity) relationship quality with parents and sisters, and current body image shame. Hierarchical linear regression analyses revealed that negative eating and weight messages from fathers, mothers, and sisters and sibling negativity were positively and significantly associated with Latinas’ body image shame. Further, we found that under conditions of high paternal psychological control but not low, the associations between fathers’ messages and Latinas’ body image shame were strengthened. For mothers, under conditions of low maternal psychological control but not high, the associations between mothers’ messages and Latinas’ body image shame were strengthened. Our findings reveal that family members’ negative comments are harmful for Latinas’ body image. ... They can describe their own and their siblings' goals and emotions, and how they harmed one another. Although children's descriptions of conflict tend to highlight the harms done to them and selectively elaborate on justifications for their own position (McGuire et al., 2000; Ross et al., 2004;Wilson et al., 2004), they can also describe ways in which they share blame for conflict. In the aftermath of having harmed their sibling, they can consider the morally laden implications of their own transgressions (Recchia & Howe, 2010;Recchia et al., 2013). ... Sibling relations in early childhood Amy L Paine Nina Howe Hildy S. Ross This chapter focuses on sibling relations in early and middle childhood, but children are acutely aware of their younger sibling from their birth, and early interaction patterns influence later development. Relationships theory posits that children's development occurs in the context of intimate and close relationships, such as with parents and siblings. Children's sibling relationships are an important influence on their developmental outcomes and a context for developing understanding of the social world. The chapter discusses features of different sibling interactions associated with individual differences in social understanding and relationship quality: teaching, play and prosocial behavior, and conflict and aggression. Prominent developmental theories (e.g., social learning, attachment) suggest that children's interactions with close family members influence their patterns of behavior, social skills, and models of relationships. Siblings play an important role in one another's development in the early years. The sibling relationship is a natural laboratory for learning about the social world. ... The most cherished moments of Manjula's life are the ones she spends with her parents during holidays. Behrman (1997) and McGuire et al. (2000) point out that siblings compete frequently for the resources, including time and attention, of parents, and the fi nancial assets and material possessions of the family. While Malini lives in Koramangala with their parents, Manjula lives in Dharwad with their grandparents. ... Understanding Rivalry: Staging Jealousy in Karnad’s “Broken Images” Acclaimed Kannada and English playwright, Girish Karnad’s play Broken Images focuses on human relationships and their intricacies, as well as on the relationship between languages. Outwardly, it addresses the sibling relationship and focuses on its destructive side. However, on a close reading, this monologue unfolds a series of diverse human relationships, viz., the relationship of the two sisters, Manjula and Malini; the husband-wife relationship between Manjula and Pramod; the camaraderie of Pramod and Malini; the friendship between Pramod and Lucy; and the amity between Lucy and Manjula. Besides these personal relationships, the play deals with and explores at length another important relationship, the one between two languages, one regional and one global, the legacy of the erstwhile colonizers. The relationship between Manjula and Malini acts as a metaphor for the mismatch and the hierarchy between regional language writers and Indian English writers on the Indian literary scene. This paper, therefore, examines the aforementioned human relationships in the play to reveal the motives behind the enmity and the causes which lead to sinful actions that remain invisible at all times, and in the process comments upon the relationship between different language writers, as well as what leads to the formation of existing hierarchies. First, the paper investigates the sororal bond between Manjula and Malini; second, it examines the tripartite relationships and how the third party is perceived as a rival in the relationships of Manjula-Lucy-Pramod and Manjula-Malini-Pramod; and finally, it looks at the relationship that exists between the Bhasha writers and Indian English writers, and exposes the enmity in these relationships and its various causes. ... In the context of the current study, key adults may make assumptions about sibling dynamics, such that the behaviours they see youth depicting (e.g., conflict) may be interpreted as 'normal' sibling behaviours, and overestimate the quality of the sibling relationship when in fact they may be perceived as problematic by the youth. For instance, sibling conflict has been reported as the most prevalent form of family violence (Straus et al., 2003) and parents are brought in to help resolve the majority of sibling conflict (McGuire et al., 2000; Ross et al., 1996). Key adults may see their role as helping siblings avoid conflict. ... Levels of agreement between youth in out-of-home care and key adults’ ratings of sibling and peer relationships: The impact of respondent characteristics and associations to youth resilience The current study utilized survey data to determine if respondent characteristics and inter-rater agreement on measures of important relationships were associated with resilience among child welfare involved youth. Youth and key adults (e.g., caregivers or caseworkers) each completed a multidimensional survey of youth well-being. Both responded to measures of sibling and peer relationships, youth also completed a brief resilience measure. Inter-rater agreement for sibling and peer relationship constructs were established through independent samples t-test, Pearson correlation coefficient, Cronbach’s kappa, and double-entry intraclass correlation coefficient. Linear regression models then examined associations of respondent and dyad characteristics to inter-rater disagreement, and inter-rater disagreement to youth reported resilience. Post-hoc analyses probed interactions for respondent characteristics and inter-rater disagreement to youth resilience. Results indicate key adults overestimated the quality of youth’s sibling relationships, and inter-rater disagreement was highest when the youth was older and the adult was a caregiver. Sibling rater disagreement was associated with higher youth reported resilience. For peer relationships, significant inter-rater disagreement was not observed. Higher relative disagreement however was associated with lower youth resilience. Findings suggest levels of inter-rater agreement may be an important consideration when assessing the well-being of youth in out-of-home care. ... Παρότι συνήθως τα αδέλφια κατά την παιδική ηλικία συγκρούονται για θέματα ισχύος ή ιδιοτέλειας (όπως ανταλλαγή προσωπικών αντικειμένων) (McGuire et al., 2000) , υπάρχουν και καταστάσεις όπου η επιθετικότητα εμφανίζεται με μορφή βίας, η οποία μάλιστα παρουσιάζεται με μεγαλύτερη συχνότητα απ' ότι άλλες μορφές παιδικής κακοποίησης (Button & Gealt, 2009). ... Εφαρμογή εκπαιδευτικής καινοτομίας με ανάλυση SWOT: Σχεδιασμός παρέμβασης με οπτική φύλου και στόχο την ολοκλήρωση της φοίτησης μαθητριών σε Εσπερινό Γυμνάσιο Article Full-text available Evangelos Papakitsos Xanthippi Foulidi Επιστημονική Επετηρίδα, τεύχος 10, σελ. 91-100. Ελεύθερα διαθέσιμο από: http://dipe.kor.sch.gr/files/epetirid10o.pdf ... Investigations of specific processes involved insibling relationships across all age groups, as wellas adolescent siblings more generally, have beenlimited until the last few decades (Feinberg, McHale,Crouter, &Cumsille, 2003;Kim, McHale, Osgood,&Crouter, 2006). Research suggeststhat siblings continue to be important influences,even as adolescents begin spending less timewith family members as they enter young adulthood(Carbery&Buhrmester; D'Amico &Fromme, 1997).Research on sibling relationships in early and middle childhood has examined someaspects of sibling relationships such as sibling conflicts(McGuire,Manke, Eftekhari, & Dunn, 2000) and conflict resolution strategies (Howe, Rinaldi, Jennings, & Petrakos,2002), and parental intervention (Ross, Filyer, Lollis,Perlman, & Martin, 1994). ... IJRMSS Journal V4, I2 Full-text available Amima Shoeb Adeel Maqbool ... However, it seems justified to refer to the psychological mechanisms that explain the results on adults such as greater egoism and focusing on the self-interest of richer people than those with a lower social status (Piff et al., 2012). This explanation seems to be justified in the case of the age group in which the study was concerned, because, as shown by the results of several studies, preschool age children are characterized by high self-centredness and concentration on self-interest (Birch & Billman, 1986;Blake & Rand, 2010; McGuire, Manke, Eftekhari, & Dunn, 2000) . ... Preschoolers’ honesty and prosocial behavior determined by a sense of wealth and poverty Preprint Dariusz Karaś Numerous studies of adults indicate that people who perceive themselves as rich are less prosocial than those who describe themselves as belonging to the poorer classes. Furthermore the state of being rich or poor affects immoral behavior. Surprisingly little is known regarding whether having more or less resources affects children’s behavior towards others. Presented study verify whether preschool children with an experimentally created sense of being rich or poor would present different social behaviors. Findings suggest that immoral behavior appears more often among children with a created sense of wealth and is an indirect effect between the prosocial behavior and the sense of wealth and poverty. ... . It corresponds with naturalistic observations indicating that spontaneous acts of sharing are relatively infrequent among toddlers and pre-schoolers when self-interest is at stake (Birch & Billman, 1986; McGuire, Manke, Eftekhari, & Dunn, 2000) . The self-centred behaviour of young children is in stark contrast with their believe in equality as a basic fairness principle and their marked inequity aversion (Fehr, Bernhard, & Rockenbach, 2008), which has been demonstrated in numerous studies using a variety of methodological approaches (e.g., Damon, 1977;Olson & Spelke, 2008;Shaw & Olson, 2012;Sommerville, Schmidt, Yun, & Burns, 2013). ... Fairness, prosociality, hypocrisy, and happiness: Children's and adolescents’ motives for showing unselfish behaviour and positive emotions Article Jun 2019 BRIT J DEV PSYCHOL Tobias Krettenauer Kathleen Bauer Sonia Sengsavang The present study examined what motives account for age‐related decreases in selfish behaviour and whether these motives equally predict positive emotions when making a moral decision. The study was based on a sample of 190 children and adolescents (101 females) from three different age groups (childhood, early adolescence, and middle adolescence, M = 12.9 years, SD = 2.58). A decision‐making task was used where participants chose between (1) maximizing their own self‐interest versus (2) being prosocial, (3) being fair, or (4) appearing fair while avoiding the costs of actually being fair. Overall, prosociality and fairness were equally important motives for unselfish behaviour. At the same time, the importance of fairness motivation increased with age. Hypocrisy motivation was less frequent than expected by chance. Prosociality was most strongly and positively associated with self‐rated happiness about the decision, whereas the opposite was found for individuals who were motivated by fairness. Overall, the study indicates that children's or adolescents’ unselfish behaviour in decision‐making tasks are driven by a variety of motives with diverse emotional implications. The relative importance of these motives changes over the course of development. Statement of contribution What is already known on this subject? • Older children behave less selfishly in resource allocation tasks. • Prosocial behaviour is associated with positive emotions. What the present study adds? • Unselfish behaviour is equally motivated by fairness and prosociality. • Fairness motivation increases from childhood throughout adolescence. • Decisions motivated by prosociality are experienced as more positive than decisions motivated by fairness. ... found that parental differential treatment was associated with intersibling differences in adolescents' delinquent behaviors. Furthermore, McGuire, Manke, Eftekhari, and Dunn (2000) showed that children who perceived higher levels of differential treatment were also more likely to report conflicted relationships with their siblings. Kowal and Kramer (1997) extended this line of research to show that siblings often evaluated the fairness of parental differential treatment; siblings who reported that differential treatment was warranted, perhaps because it was performed in the service of meeting the unique needs, characteristics, and interests of individual children, reported more positive relationships with siblings than those who perceived parental differential treatment to be unfair. ... Siblings Chapter Full-text available Apr 2019 Laurie F Kramer Katherine J Conger Christy Rae Rogers Niyantri Ravindran In this chapter, we examine how siblings and sibling relationships affect, and are affected by, other family relationships. One key objective is to help researchers , educators and practitioners move beyond the traditional parent-driven model of how families operate to explore some of the ways that children-who are growing up with siblings-also affect the quality of family life. In so doing, we will consider some of the mutual influences of parent-child, marital , and sibling subsystems over the life course. As we examine relevant research and theory, we aim to enhance our understanding of the roles that sibling relationships play in promoting resilient families. More specifically, we will ask whether positivity in sibling relationships results in better functioning for individuals, parents, and for families as a whole-and, if so, whether this is true across the life course. In the United States, approximately 85% to 90% of families include multiple children (Milevsky, 2011). This means at least two things: First, children largely grow up in contexts that include other children , each of whom faces her or his own developmental challenges. And, second, that in addition to meeting the unique needs of each of their children as individuals, parents are also challenged to support and manage their children's relationships with one another (Dunn, 2014; Kramer, 2010). The implications of these two factors are powerful. At the very least, they require researchers, educators, and practitioners to move beyond the "social address models" of sibling relations that are concerned with the potential influences of immutable factors, such as birth order, age spacing, and sex constellation, and to examine the dynamic qualities of sibling relationships and their role in family systems. View Show abstract ... Research on birth order tends to focus on the impact that birth order has on children's futures, considering how it may shape their personalities (Berthoud 1996;Sulloway 1996) as well as influence their successes and failures as adults (Conley 2004;Leman 2002). Psychological literature has tended to perceive siblings in relation to the "roles" and "expectations" of their birth order position (Boer and Dunn 1992; McGuire et al. 2000; Sutton-Smith and Rosenberg 1970). However, there is a lack of geographical or sociological studies on birth order Evans 2012). ... Negotiating Sibling Relationships and Birth Order Hierarchies Chapter Jan 2018 Samantha Punch ... Several researchers have been able to elicit sharing among preschool aged children (Brownell, Svetlova, & Nichols, 2009;Fehr, Bernhard, & Rockenbach, 2008;Moore, 2009;Thompson et al., 1997;Williams et al., 2014), with the literature converging on the idea that children as young as 2 know that it is important to share (e.g., Rheingold et al., 1976). However, several other researchers found that while children under the age of 7 understand the importance of sharing, they did not actually engage in sharing behaviour (Birch & Billman, 1986;Eisenberg-Berg & Hand, 1979; McGuire, Manke, Eftekhari, & Dunn, 2000; Smith, Blake, & Harris, 2013). Thus, there is a considerable amount of variation exhibited in children's decisions to share with others. ... The role of empathy and motivational context on children's prosocial lying and responding Thesis Aug 2017 P. Megha Nagar ... Research on birth order tends to focus on the impact that birth order has on children's futures, considering how it may shape their personalities (Berthoud 1996;Sulloway 1996) as well as influence their successes and failures as adults (Conley 2004;Leman 2002). Psychological literature has tended to perceive siblings in relation to the "roles" and "expectations" of their birth order position (Boer and Dunn 1992; McGuire et al. 2000; Sutton-Smith and Rosenberg 1970). However, there is a lack of geographical or sociological studies on birth order Evans 2012). ... Negotiating Sibling Relationships and Birth Order Hierarchies Chapter Jan 2017 Samantha Punch This chapter argues that the birth order is socially constructed and shows how birth order hierarchies are negotiated in everyday interactions between siblings. It explores the relative opportunities and constraints of children’s birth order positions within families. The chapter indicates that both children and parents recognize the existence of age and birth order hierarchies and that this may influence how siblings behave as well as how they are treated by family members. However, the ways in which age and birth order hierarchies are played out in children’s everyday lives are dynamic and do not follow rigid rules. The benefits and limitations of being in any birth order position are negotiated, contested, and accepted in a multitude of ways across different sibling groups. The chapter draws on the perspectives of older, middle, and younger siblings in order to demonstrate the many tensions and complexities which surround the perceived strengths and weaknesses of different locations in the birth order. ... Investigating this question would allow us to gain a more comprehensive understanding of what issues are likely to draw additional family members into a dispute, even if they are not previously or directly involved. While sibling disputes that require parental intervention concern issues related to possession, aggression, and obnoxious behavior (McGuire, Manke, Eftekhari, & Dunn, 2000) , this question has not been investigated in the context of the additional roles assumed during polyadic conflicts. In addition, Vuchinich et al. included a wide age range of children crossing several developmental periods; this makes it difficult to disentangle age and developmental factors associated with the processes of conflict resolution (Raffaelli, 1992). ... Family members' helping behavior: Alliance formations during naturalistic polyadic conflicts: Alliances in polyadic family conflicts Ryan J. Persram Nina Howe Sandra Della Porta Hildy S. Ross The present study investigated the role of alliances in naturalistic polyadic conflicts, which involved at least three family members, through a comparative analysis of parent–child‐ and sibling‐originated conflicts. Thirty‐nine families with two children (aged 4 and 6 years) were observed in the home setting. Transcripts of six 90‐min observational sessions per family resulted in identifying 306 polyadic family sequences; conflict initiators, topic, and resolution, as well as additional party roles (e.g., ally, judge, additional combatant, and mediator), were coded. Findings reveal that despite all family members being involved in polyadic conflicts, children tended to be initiators, while parents were more involved as additional parties. Alliances occurred more often than the other types of additional party roles. Alliance partnerships were most evident between mothers and fathers in parent–child‐originated conflicts, and mothers were more likely to ally with the younger child in sibling‐originated conflicts. Finally, submission was the most common resolution of polyadic conflicts; however, allies were more likely to win conflicts than to compromise or lose. This study highlights the dynamic nature of family conflict at home and is discussed in terms of links between relationships with family members, as well as informal learning of conflict behaviors. Highlights • Conflicts involving three or more family members occurs quite often at home. • Alliances are a common role that family members assume in conflict, as they try to achieve a favourable outcome for their side. • Children's involvement both as initiators and additional parties highlight their learning of various complex conflict behaviours in childhood. ... When young children are in possession of resources, they are not very generous in giving them away to others. This is apparent both in natural observations in which preschool children are mostly reluctant to share their toys with others (e.g., Eisenberg-Berg & Hand, 1979;Levitt, Weber, Clark, & McDonnell, 1985; McGuire, Manke, Eftekhari, & Dunn, 2000) and in experimental situations resembling a dictator game in which preschool donators across many different cultures tend to keep the majority of resources for themselves (e.g., Benenson, Pascoe, & Radmore, 2007;Blake & Rand, 2010;Fehr, Bernhard, & Rockenbach, 2008;Rochat et al., 2009;Thompson, Barresi, & Moore, 1997). This is despite the fact that, when asked, 3-year-olds explicitly endorse the principle of egalitarianism (Smith, Blake, & Harris, 2013). ... How 18- and 24-month-old peers divide resources among themselves J EXP CHILD PSYCHOL Julia Ulber Katharina Hamann Michael Tomasello ... Pour les jeunes adultes, un frère ou une soeur représente quelqu'un ou quelqu'une de fiable, qui est là et sur qui ils peuvent compter en cas de besoin (Floyd, 1995). Cependant, comme en témoignent les travaux de Raffaelli (1996 ) et McGuire, Manke, Eftekhari et Dunn (2000 , les relations entre les frères et soeurs sont également source de conflits. ... La Qualité Des Relations Fraternelles Chez Des Jeunes Ayant Connu ou Non Une Transition Familiale Article Jan 2002 Can J Community Ment Health Marie Simard Madeleine Beaudry Sylvie Drapeau Cécile Charbonneau In this study, similarities and differences in sibling relationships between children who have experienced family transitions and those who have not are examined. Comparisons are made between children who live in intact families, those whose parents have separated, and those who live in substitute care regarding the quality of their relationships with one of their siblings. More specifically, 4 dimensions describing the quality of sibling relationships are compared: Warmth/Closeness, Conflict, Relative Status/Power, and Rivalry (Furman & Buhrmester, 1985). The sample is made up of 3 groups of children (N = 158) aged between 8 and 12 years old: children living in intact families (n = 101), children who have experienced parental separation (n = 35), and children living in substitute care (n = 22). Results indicate differences on dimensions of Warmth/Closeness, Conflict, and Relative Status/Power. Different patterns of responses between the children who have experienced family transitions and those who have not are observed for the dimensions of Conflict and Power. The significant difference observed between the groups for the dimension of Warmth appears difficult to explain. Discussion of these results emphazises the importance of the relationship between brothers and sisters experiencing family transition. ... It is possible that these older children are appraising the cancer as more threatening because they understand that the ill child may die from the cancer, whereas some very young children cannot reach this conclusion. As well, due to different developmental stages, children at different ages may focus on different aspects of the cancer experience (McGuire, Manke, Eftekhari, & Dunn, 2000) . For example, younger children may focus on the loss in family routines because that may be the most challenging aspect of being the sibling of a child with cancer for them, whereas older children may focus more on the health related concerns for the child who is ill (Hoffman, 1991). ... “Cancer is a family diagnosis and it just hits everybody in a different way”: The Non-shared Experiences of the Siblings of Pediatric Cancer Patients Article Aug 2011 Laura Calvert ... One possible explanation relates to the meaning of parent-rated sibling conflict and parents' strategies for managing that conflict. Some parents might view frequent sibling conflict as a recurring need to respond to unpleasant whining or tattling (McGuire et al. 2000) . Research has shown that parents' approach to managing sibling conflict can convey important messages to children about how to respond to conflict, and not all of the messages are adaptive (Perlman et al. 2007). ... Conflict and Dominance Between Siblings as Predictors of Children’s Peer Victimization Article Full-text available Mar 2015 Melissa A Faith Lawrence Christian Elledge Rebecca A. Newgent Timothy A Cavell This study examined relations among sibling conflict, sibling dominance, and peer victimization. Participants were 65 elementary school students and their parents, with additional data provided by teachers and classmates. Structured interviews were used to gather information about children’s relationship with their nearest-age sibling. Findings differed substantially based on parent versus child sibling conflict ratings. Sibling dominance negatively predicted parent-rated sibling conflict. Sibling dominance moderated the relation between child-rated sibling conflict and self-rated peer victimization such that sibling conflict positively predicted peer victimization for dominant siblings, but negatively predicted victimization for children who were submissive to their sibling. The linear and curvilinear sibling dominance terms moderated relations between sibling conflict and peer victimization as rated by teachers and peers, but the nature of interactions varied by parent versus child report of sibling conflict. Children regarded by parents as engaging in frequent sibling conflict were at greater risk of teacher- and peer-reported victimization, but not if the child was dominant over their sibling. The curvilinear dominance term also moderated the relation between child-rated sibling conflict and peer-reported victimization. Child-rated conflict negatively predicted victimization for children in balanced sibling relationships but positively predicted victimization for children in sibling dyads characterized by dominance disparity. Findings are complex, but suggest healthy sibling relationships characterized by balanced levels of social dominance can protect against peer victimization. ... In addition, both preschool girls and boys with (especially older) brothers have been found to be more masculine and less feminine in their interests, activities, and characteristics than children with sisters (Rust et al., 2000). Quality of the sibling relationship may also vary for different sibling gender combinations (McGuire, Manke, Eftekhari, & Dunn, 2000) , which in turn can influence child behavior (Scholte, Engels, De Kemp, Harakeh, & Overbeek, 2007). For example, there is evidence that girls are generally more positive and nurturing toward their younger siblings than boys (Dunn, Deater-Deckard, Pickering, & Golding, 1999), but especially when the younger sibling is a girl (Kier & Lewis, 1998). ... Sibling Gender Configuration and Family Processes Article Feb 2015 J FAM ISSUES Lotte D. van der Pol Judi Mesman Marleen Groeneveld Marian bakermans-kranenburg The current study focuses on the effects of sibling gender configuration on family processes during early childhood. In a sample of 369 two-parent families with two children (youngest 12 months, oldest about 2 years older), both siblings’ noncompliant and oppositional behaviors and fathers’ and mothers’ sensitivity and discipline strategies were observed. Both siblings’ aggressive behaviors and empathy of the oldest sibling were assessed with parent-reports. Children in families with two sons showed more problematic interaction patterns compared with children in families with an oldest girl. In families with two boys, older siblings were more aggressive and fathers were less sensitive toward their youngest child in comparison with families with two girls. Furthermore, in boy-boy families older siblings showed more oppositional behavior and younger siblings more noncompliance compared with girl-boy families. These findings highlight the importance of sibling gender configuration in the development of child behavior and parent-child interactions. ... However, this article emphasizes the importance of social context and children's own understandings of the sibling order (Edwards et al., 2005a). Much of the focus of extant scholarship concerned with siblings is upon rivalry, conflict and support networks (Bank and Kahn, 1982; McGuire et al., 2000 ). Forms of exchange and relations of reciprocity have been underresearched . ... McIntosh, I. and Punch, S. (2009) ‘Barter’, ‘deals’, ‘bribes’ and ‘threats’: Exploring Sibling Interactions, Childhood, 16 (1):49-65. Article Full-text available Jan 2009 Samantha Punch Sibling Influences on Prosociality: From Infancy to Adolescence Chapter May 2023 Claire Hughes Gabrielle McHarg Alison Pike Prosociality is a multifaceted concept referring to the many ways in which individuals care about and benefit others. Human prosociality is foundational to social harmony, happiness, and peace; it is therefore essential to understand its underpinnings, development, and cultivation. This handbook provides a state-of-the-art, in-depth account of scientific, theoretical, and practical knowledge regarding prosociality and its development. Its thirty chapters, written by international researchers in the field, elucidate key issues, including: the development of prosociality across infancy, childhood, adolescence, and beyond; the biological, cognitive, emotional, and motivational mechanisms that underlie and influence prosociality; how different socialization agents and social contexts can affect children's prosociality; and intervention approaches aimed at cultivating prosociality in children and adolescents. This knowledge can benefit researchers, students, practitioners, and policy makers seeking to nurture socially responsible, caring youth. Typical and Atypical Child and Adolescent Development 7: Social Relations, Self-awareness and Identity فاعلية برنامج إرشادي في تحسين جودة الحياة والعلاقات الأخوية لدى الأخوة العاديين، وأثره في تنمية السلوك التكيفي لأخيهم المصاب بمتلازمة داون This study aims to explore the effectivess of a designed counseling program for improving the quality of life, and the Sibling Relationship among « normal » brothers, in addition to improving the adjustment behaviour of their handicaped brothers. The hypothesis is : The designed counseling program helps to improve the psychological quality of life, and the Sibling Relationships among «normal» brothers. The program improves also the « adjustment behavior » of the brothers who have Down syndrome. The methodology is based on a quasi-experimental longitudinal approach. One group design with before and after testing was used. To test this study hypothesis Ten « normal » adolescents who are brothers of handicaped were selected. Their age ranges between 13 and 18 years. The sample is selected from Two places : ‘Mentally Retarted Children Pedagogical Center’, and ‘Mentally Handicaped Children Hope Association in chlef state. The researcher used the following instruments :sibling relationship questionnaire prepared by Furman & Buhrmester (1985), Quality of psychological life scale prepared by Caroll Ryff (1989), American Adaptation Behavior Scale of Mental retardation (2004), This scale is translated by Al Hussein (2004), and counseling program for improving the quality of life, and the brotherhood relations among « normal » brothers, in addition to improving the adjustment behaviour of their handicaped brothers. This program is prepared by the researcher. Data analysis was performed by using SPSS program. The results partially confirmed the hypothses, which implies that the designed counseling program was effective in improving the psychological life quality, and the brotherhood relationships, and in improving the adaptation behavior of the handicaped brothers who safer from Down syndrome. The results were discussed on the basis of literature review, previous studies, and on the basis of the sample characteristics هدفت الدراسة الحالية بشكل أساسي إلى معرفة فاعلية برنامج إرشادي في تحسين جودة الحياة والعلاقات الأخوية لدى الأخوة العاديين، وأثره في تنمية مهارات السلوك التكيفي لدى الاخوة المعاقين عقليا المصابين "بمتلازمة داون"، وذلك انطلاقا من الفرضية التالية: يعين البرنامج الارشادي في تحسين جودة الحياة النفسية والعلاقات الأخوية لدى الإخوة العاديين، وتنمية مهارات السلوك التكيفي لدى الاخوة المعاقين المصابين "بمتلازمة داون". تم استخدام المنهج شبه التجريبي من خلال التصميم التجريبي لمجموعة واحدة بتطبيق قبلي وبعدي وتتبعي. وقد تكونت عينة الدراسة من (10) مراهقين من إخوة الاطفال المعاقين المصابين "بمتلازمة داون" القابلين للتعلم الذين تتراوح أعمارهم بين (13 -18) سنة. تم اختيار العينة من "المركز البيداغوجي للأطفال المتخلفين عقليا"، "وجمعية الأمل للاطفال المعاقين" عقليا على مستوى ولاية الشلف. تمثلت أدوات الدراسة في: استبيان العلاقات الاخوية من إعداد "فورمان وبهرمستر" "Furman& Buhrmester "(1985) ، ومقياس جودة الحياة النفسية من إعداد "كارول رايف" "Ryff"(1989)، ومقياس السلوك التكيفي للجمعية الأمريكية للتخلف العقلي(AAMR, ABS, S:2) من تقنين وتعريب "عبد الله الحسين"(2004) ، وبرنامج إرشادي موجه لإخوة المعاقين المصابين بمتلازمة داون، من إعداد الباحثة. استخدمت الباحثة الأساليب الإحصائية المناسبة لطبيعة الدراسة ، ومتغيراتها وحجم العينة، عن طريق البرنامج الاحصائي للعلوم الاجتماعيةspss 20 . وقد تجلت أهم نتائج الدراسة في تحقق فروضها بشكل جزئي، مما يعنى أن البرنامج الارشادي كان ذو فاعلية في تحسين جودة الحياة النفسية والعلاقات الأخوية لدى الاخوة العاديين، وتنمية مهارات السلوك التكيفي لدة الاخوة المعاقين المصابين بمتلازمة داون. تم مناقشة نتائج الدراسة على ضوء الدراسات السابقة وخصائص عينة الدراسة. Psychological Well-Being and Family Functioning in Middle Childhood: The Unique Role of Sibling Relational Dynamics Despite being the longest relationships across the lifespan, the sibling dyad is the most under-studied relationship in the family system. Researchers have documented the harmful and beneficial effects of sibling relationships and family dynamics on individual well-being. Extending this research to middle childhood, the current study examined family functioning, sibling relational dynamics, and self-reported adjustment and internalizing symptoms among 8- to 11-year-old children. Path analyses revealed significant direct effects between conflictual family functioning and children’s psychological well-being. Significant interactions between family functioning and sibling dynamics suggested that congruent relational dynamics at multiple levels of the family system had a cumulative impact on the child’s well-being. Findings from the current study highlight the role of family functioning and the unique contributions of sibling relationships to children’s functioning, suggesting that consideration of sibling relational dynamics may improve treatment planning by pointing out additional targets for intervention and/or potential sources of support. Impact On Siblings This chapter draws on the work of some seminal authors to explore theoretical perspectives surrounding the sibling, the sibling relationship and factors that impact on sibling social development, as this will provide a foundation before exploring and giving an insight into the wider issues and influences that can impact upon them as a consequence of the chronic illness trajectory. Siblings as care‐givers are also explored. Sibling conflict can result in positive outcomes for siblings as it can help them to develop social competence in terms of dealing with different situations, as well as help in the formation of identity and development of self. The chapter discusses supportive interventions that can be used to help understand the needs and care of siblings within their family. Case studies are used to explore different aspects of sibling experiences, using cystic fibrosis as the long‐term illness example. Sibling Relationships in Adolescence Across Cultures: Predictors, Transitions, and Support In addition to being the most long-lasting relationship an individual can develop, the sibling relationship has the potential of offering unique cognitive, social, and emotional provisions throughout the lifespan. This potency is particularly distinct during adolescence, a time of shifting identity and social constellations. This chapter will review research findings on the structural and familial predictors of sibling relationship quality during adolescence. In addition to gender, age, age gap, family size, and gender tilting factors that may impact sibling relationship quality, familial characteristics, particularly parent base factors, have been shown to impact sibling relationship quality both indirectly and directly. The chapter will also assess outcomes associated with sibling support and will examine these predictors and outcomes within a cultural context. Genetic Relatedness, Emotional Closeness and Physical Aggression: A Comparison of Full and Half Sibling Experiences Two studies investigated whether perceived closeness of siblings, and aggression between siblings, were associated with genetic relatedness. In following Hamilton’s rule, we predicted that as the coefficient of relatedness between siblings increased, emotional closeness would also increase while conflict would decrease. Contrary to the predictions, we found no effect of genetic relatedness in Study 1 when we compared participants’ (n = 240) ratings of emotional closeness; participants also reported significantly higher levels of conflict with full siblings than with half siblings. In Study 2, participants (n = 214) also reported a higher frequency of physical aggression with full siblings than with half siblings. These findings were contrary to the prediction from Hamilton’s rule. We discuss them in relation to parental investment in biological and non-biological offspring. Quality of sibling relationship and family functioning in Greek families with school-age children The aim of the current study is to examine the quality of sibling relationships in relation to family functioning in Greek families with typically developing school-age children. The sample: 251 intact Greek families with two children (251 parents — 1 parent participated from each family — and 251 children). Research instruments: (a) the Family Adaptability and Cohesion Evaluation Scales III (FACES III; Olson, 1986), administered to both parents and children), (b) the Sibling Relationship Questionnaire (SRQ; Furman& Buhrmester, 1985); and (c) the family constellation: number of children, birth order, gender and socioeconomic level. According to the findings, the quality of a sibling relationship is associated with family cohesion and adaptability. Regarding children’s gender, the Warmth/Closeness scale is lower in families with children of different gender compared to families with children of the same gender. Regarding birth order, first-born children report higher levels of cohesion (ideal and actual), as well as higher Warmth/Closeness (children and parents), in comparison to the second-born children. Regarding parental educational level, parents and children report a higher level when it comes to ideal family and cohesion type (ideal level), as well as higher Warmth/Closeness (parents) when at least one of the parents has a university education background. Chapter 3: The Positional Self and Researcher Emotion: Destabilising Sibling Equilibrium in the Context of Cystic Fibrosis Sibling Caregiving and Its Implications in Sub-Saharan Africa Most children worldwide grow up with at least one sibling, and the sibling relationship is usually the longest-lasting one in a person’s life. Understanding sibling relationships therefore is important as it contributes to our understanding of human development. This chapter attempts to make a contribution to the knowledge base on sibling interactions by discussing the implications of sibling caregiving in sub-Saharan Africa. The roles siblings play in individuals’ social and cognitive development and mental health are described. In addition, sibling caregiving in sub-Saharan Africa and specifically sibling caregiving among the Agikuyu of Kenya are described. In the conclusion section, some policy implications for child development, learning, and educational processes are presented. Family Perspectives on Siblings’ Conflict Goals in Middle Childhood: Links to Hierarchical and Affective Features of Sibling Relationships: Family Perspectives on Siblings’ Conflict Goals in Middle Childhood This study examined parents’ and children's descriptions of older and younger siblings’ conflict goals in the late preschool and middle childhood years, and how these attributions were related to sibling relationship quality. Parents and 4- to 10-year-old children from 62 families were interviewed separately about siblings’ motivations in two disputes and completed assessments of sibling relationship quality. Goal attributions varied across respondents in ways reflecting their family roles and positioning within disputes. Findings also revealed variations in the goals ascribed to older and younger siblings in line with hierarchical features of sibling relationships, such as younger siblings’ conciliation/connectedness motives and older siblings’ desires for autonomy/respect. Goal attributions were related to differences between families in the affective tenor of sibling relationships. Results demonstrate how power dynamics in sibling relationships play out in their everyday disputes, and underscore the importance of considering different family members’ unique perspectives on children's sibling conflict experiences. Destructive Sibling Aggression Destructive sibling aggression is presumably the most widespread form of interpersonal hostility. It is associated with a wide array of negative consequences. Yet it has been relatively overlooked by researchers, educators, and practitioners, compared to other forms of aggression. Sibling maltreatment remains perhaps the only form of socially sanctioned violence. This chapter will provide an overview of sibling aggression and its normalization, highlight its different types and estimates of prevalence, its links to negative developmental outcomes, describe the factors that support it, and present prevention and intervention considerations. Finally, implications for practice, education and research are offered. Developmental Differences in Infants' Fairness Expectations From 6 to 15 Months of Age The present research investigated the developmental trajectory of infants' fairness expectations from 6 to 15 months of age (N = 150). Findings revealed a developmental transition in infants' fairness expectations between 6 and 12 months, as indicated by enhanced visual attention to unfair outcomes of resource distribution events (a 3:1 distribution) relative to fair outcomes (a 2:2 distribution). The onset of naturalistic sharing behavior predicted infants' fairness expectations at transitional ages. Beyond this period of developmental transition, the presence of siblings and infants' prompted giving behavior predicted individual differences in infants' fairness concerns. These results provide evidence for the role of experience in the acquisition of fairness expectations and reveal early individual differences in such expectations. Familial Relationships Kinship has been a central organizing principle in evolutionary explorations of social behavior ever since Hamilton (J Theor Biol 7:1–52, 1964) extended the concept of Darwinian fitness benefits to include actions that benefit not only own offspring but also collateral kin. This insight into humans as nepotistic strategists has fueled an extensive literature on the adaptations that make up the repertoire that is our family psychology from those that shape mothers’ and fathers’ substantial investment in offspring, to parent–offspring conflict over the allocation of investment, to sibling conflict and cooperation, and the valuable investment that some grandparents make to the survival and success of their grandchildren. No understanding of social behavior can be complete without understanding where it all starts: with the families we grow up in. Sibling relationship in early/middle childhood: Trait- and dyad-centered approach In a two-year prospective longitudinal study, mothers and fathers of 93 sibling dyads in early childhood reported on perceived characteristics of their children's sibling relationship. At the beginning of the study, all of the children attended pre-school institutions. Younger children were on average 3 years old and their siblings were on average 2 years older. One year later, 53 of the older siblings entered primary school. The Parental Expectations and Perceptions of Children's Sibling Relationships (Kramer, 2001a) questionnaire was used as a measure of three dimensions of the sibling relationship, i.e. warmth, agonism and rivalry/competition. Interrater agreement, differences between maternal and paternal data sources, age changes and temporal stability of the sibling relationship over a period of one year were investigated at two levels of analyses, applying a trait- and a dyad-centered approach. Results showed a moderate interrater agreement between spouses reporting on same sibling dyads and a moderate temporal stability of the three dimensions of sibling relationship within as well as across the reporters. Dyad-centered analysis revealed three sibling relationship types. The Affectionate type was characterized by relatively high warmth and low agonism as well as by low rivalry/competition. Parents of sibling dyads engaged in the Involved relationship observed high levels of expression of the three dimensions of sibling relationship, while sibling dyads classified within the Average sibling relationship type were ascribed moderate levels of warmth, agonism, and rivalry/competition. The empirically derived sibling relationship types were established as internally replicable and structurally stable across data sources and over time. However, the individual consistency and temporal stability of type membership were estimated as low across the reporters. Positive illusions have been explained either through the limited functions of the cognitive system or through the egocentric construction of memory and attention. We argue that the function of positive illusions can be better understood by integrating them in the process responsible for forming the cognitive anthropological architecture and some specific problems to which we have had to find solutions throughout our evolution. The purpose of this study is to offer some original explanations to the question "for what reason and in which way positive illusions occurred" and to analyze illusions from a theoretical perspective in which the anthropological, biological, psychological and social models could be possibly integrated. Siblicide in Humans and Other Species Sibling conflict is common across a wide variety of species, including humans. It is an expected process because offspring compete for dominance as well as food resources (most common in nonhuman species) and also for parental attention, money, and other personal resources in the case of human children. While most conflict in humans has no long lasting effects, under some circumstances, sibling conflict can turn violent and even result in death, what is commonly referred to as siblicide. While siblicide is quite rare in humans, from an evolutionary perspective, we would expect it to be influenced by some of the same factors as less intense sibling conflict. Such factors include sex of sibling, resource availability, birth spacing, and relatedness. These factors will be discussed with respect to research on sibling conflict and siblicide in human and nonhuman species. A Self-Serving Bias in Children's Memories? Although children's initial perceptions and judgments about sociomoral situations are being actively explored, little is known about what children remember about them. In four experiments testing over 400 children, we investigated children's memories for small acts of giving and taking. When asked to recall their own giving and taking, children were relatively accurate following a number of delays. In contrast, when asked to recall a child's giving or taking, children exaggerated the child's taking after a 1-day or 1-week delay. Notably, this pattern of misremembering occurred only when children recalled the actions of a child but not an adult. We consider the idea that children spontaneously engage in social comparison, which colors their memories of the social world. (PsycINFO Database Record (c) 2015 APA, all rights reserved). Assessed children's worries about the behaviors of significant people in the family with a new measure that focused on both the target of the worry and the types of behavior that worry the child. One hundred twenty-one 7 to 12-year-old in families with and without domestic violence rated, on a 4-point scale ranging form 1 (not a lot) to 4 (a lot) how much they worried about 20 behaviors concerning five people in the family: mother, father, brother, sister, and self. Varimax analyses provided two factors - Vulnerable and Harmful - that indicate worry about the vulnerable and harmful behavior of each family member. The measure has acceptable internal and test-retest reliability, as well as known-groups validity. Children in the domestic violence families were significantly more worried about the vulnerability of their mothers, brothers, and sisters, and they tended to worry more about the harmful behavior of their fathers than did children in the comparison group. Significant associations were found, for the children of battered women, between child adjustment and worry about the harmful behavior of family members. Examined change in prosocial moral judgment over a 7-year period; determined whether there are gender differences in the development of prosocial moral judgment; and examined the interrelations of moral judgment, affect (empathy), and behavior in middle childhood. Participants were two groups of children who have been followed for 5 and 7 years and two groups of children interviewed for the first time at either ages 9–10 or 11–22. Hedonistic reasoning decreased with age; simple needs-oriented moral judgments increased with age and then leveled off; most other more sophisticated types of reasoning increased in a linear fashion with age. Modes of reasoning that most explicitly reflect role taking or empathy increased in use with age for girls but not for boys. Empathy was positively related to needs-oriented judgments and to higher-level prosocial reasoning and was negatively related to hedonistic reasoning (depending on the age of the children). Empathy was positively related to donating at 11–22 years of age but not at 9–20 years of age. Relations between behavior and reasoning varied depending on the structure and costs of a specific behavior. The results are discussed in relation to theory and research concerning developmental change in moral reasoning and possible mediators of prosocial development. (PsycINFO Database Record (c) 2012 APA, all rights reserved) the main focus of developmental psychopathology research has been on identifying factors that increase children's risk of psychological difficulties / in more recent years attention has also been given to factors that might ameliorate or lessen the impact of negative experiences on children / there are two important questions to consider in relation to sibling relationships in stressful circumstances / the first relates to whether there is any difference in the frequency of positive relationships between children in stressful family circumstances and those in non-stressful family circumstances / the second issue relates to the potential benefit of sibling relationships for children under stress aim in this chapter is to present data pertaining to whether children are protected by close sibling relationships, to distinguish between factors that are protective and those that increase children's risk, and to compare the frequency of negative and positive sibling relationships in disharmonious and harmonious homes [the samples for the study] were 83 families in which the marriage had been rated as disharmonious . . . and 83 families in which the marriage had been rated as harmonious / children were between 9 and 12 years old / parents were interviewed in their homes simultaneously but separately using a semi-structured interview / children were interviewed approximately 1 week later (PsycINFO Database Record (c) 2012 APA, all rights reserved)
https://www.researchgate.net/publication/229784136_Children%27s_Perceptions_of_Sibling_Conflict_During_Middle_Childhood_Issues_and_Sibling_Dissimilarity
JCM | Free Full-Text | Prehospital Point-Of-Care Lactate Increases the Prognostic Accuracy of National Early Warning Score 2 for Early Risk Stratification of Mortality: Results of a Multicenter, Observational Study The objective of this study was to assess whether the use of prehospital lactate (pLA) can increase the prognostic accuracy of the National Early Warning Score 2 (NEWS2) to detect the risk of death within 48 h. A prospective, multicenter study in adults treated consecutively by the emergency medical services (EMS) included six advanced life support (ALS) services and five hospitals. Patients were assigned to one of four groups according to their risk of mortality (low, low-medium, medium, and high), as determined by the NEWS2 score. For each group, the validity of pLA in our cohort was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. In this study, 3081 participants with a median age of 69 years (Interquartile range (IQR): 54–81) were included. The two-day mortality was 4.4% (137 cases). The scale derived from the implementation of the pLA improved the capacity of the NEWS2 to discriminate low risk of mortality, with an AUC of 0.910 (95% CI: 0.87–0.94; p < 0.001). The risk stratification provided by the NEWS2 can be improved by incorporating pLA measurement to more accurately predict the risk of mortality in patients with low risk. Prehospital Point-Of-Care Lactate Increases the Prognostic Accuracy of National Early Warning Score 2 for Early Risk Stratification of Mortality: Results of a Multicenter, Observational Study Raúl López-Izquierdo 3,* , Juan F. Delgado Benito 2 , Ancor Sanz-García 4,† , Carlos del Pozo Vegas 5 , Miguel Ángel Castro Villamor 1 , José Luis Martín-Conty 6 and Guillermo J. Ortega 4,7 CONICET, C1425FQB Buenos Aires, Argentina * Author to whom correspondence should be addressed. † These authors contributed equally to this work. J. Clin. Med. 2020 , 9 (4), 1156; https://doi.org/10.3390/jcm9041156 Received: 21 March 2020 / Revised: 12 April 2020 / Accepted: 14 April 2020 / Published: 18 April 2020 (This article belongs to the Section Emergency Medicine ) Abstract : The objective of this study was to assess whether the use of prehospital lactate (pLA) can increase the prognostic accuracy of the National Early Warning Score 2 (NEWS2) to detect the risk of death within 48 h. A prospective, multicenter study in adults treated consecutively by the emergency medical services (EMS) included six advanced life support (ALS) services and five hospitals. Patients were assigned to one of four groups according to their risk of mortality (low, low-medium, medium, and high), as determined by the NEWS2 score. For each group, the validity of pLA in our cohort was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. In this study, 3081 participants with a median age of 69 years (Interquartile range (IQR): 54–81) were included. The two-day mortality was 4.4% (137 cases). The scale derived from the implementation of the pLA improved the capacity of the NEWS2 to discriminate low risk of mortality, with an AUC of 0.910 (95% CI: 0.87–0.94; p < 0.001). The risk stratification provided by the NEWS2 can be improved by incorporating pLA measurement to more accurately predict the risk of mortality in patients with low risk. Keywords: biomarkers ; clinical decision-making ; clinical deterioration ; early warning ; emergency medical services ; mortality ; patient safety 1. Introduction Assistance to people with acute disease in the prehospital context has evolved rapidly in recent years, making it possible to diagnose and treat bedside pathologies on many occasions [ 1 ]. Thanks to research in this field and to the implementation of specific protocols and technological developments, we now have tools that can be employed at the scene or on the road, which can help to evaluate the actual state of a patient from the very first contact of the emergency medical services (EMS) until the arrival at the emergency department (ED) [ 2 ]. The use of early warning scores (EWS) is a reality in the current clinical practice [ 3 ] and has become a standard procedure in many contexts and pathologies [ 4 , 5 ]. Among all scores, the National Early Warning Score 2 (NEWS2) [ 6 ] has proven to be useful in the prehospital context, is validated, and commonly used internationally [ 7 , 8 , 9 ]. Moreover, technological development has led to the use of rapid-response point-of-care testing [ 10 , 11 ], as such is the case of prehospital lactate (pLA), which is a sensitive indicator of tissue hypoperfusion, reliable, and easy to obtain [ 12 , 13 ]. One challenge faced by the EMS is the capability of detecting risk of mortality in patients with acute diseases [ 14 ], fundamentally in time-dependent pathologies where a diagnostic or therapeutic delay may negatively influence the outcome, thereby increasing morbidity and mortality [ 15 ]. In addition, these pathologies may not be suspected or detected initially. In these contexts, the use of any aid that can discriminate the risk of mortality should be evaluated because it can reduce the interval for definitive qualified health care [ 16 ]. The use of EWS and biomarkers represents a fundamental tool that enables the systematized evaluation of the patient and can predict possible serious adverse events (SAEs), individualizing the assessment and care of each patient [ 17 ]. EWS and biomarkers have been used separately and in combination [ 18 , 19 ]. Specifically, the relationship between the NEWS2 and lactate has been analyzed in diverse clinical contexts [ 20 , 21 , 22 ]. Our main objective was to analyze whether the use of pLA increases the prognostic capacity of the NEWS2 to predict the risk of early mortality in people with acute disease treated by EMS. 2. Material and Methods 2.1. Study Design We conducted a prospective, multicenter study in adults treated consecutively by the EMS and transported in advanced life support units (ALS) to referral hospitals between 1 October 2018 and 3 November 2019. The present study was in accordance with Good Clinical Practice and the Declaration of Helsinki. The Research Ethics Committee of each participating institution approved the protocol. (REC number: #PI 18-010, #PI 18-895, #PI 18-10/119, #PI MBCA/dgc and #PI 2049). All patients (or guardians) signed an informed consent. The study was coordinated by the Advanced Clinical Simulation Center of the Faculty of Medicine at Valladolid University. This study is reported in line with the STROBE statement. 2.2. Study Setting The study was conducted in six ALS and five hospitals (four tertiary university hospitals and one small general district hospital) of the public health system of Castile and Leon (Spain) with a reference population of 1,364,952 inhabitants. The sample size calculation was performed using an area under the curve (AUC) of the expected receiver operating characteristic (ROC) of 90% with a confidence level of 99% and an accuracy of 1%, with 2543 subjects. We estimated a follow-up loss in 5%, so the estimated final sample size was 2677 subjects, for an early mortality rate of 4%, in line with similar studies [ 7 , 11 , 18 ]. Each ALS was composed of a medical doctor, an emergency registered nurse (ERN), and two paramedics. These units operate nonstop 24 h a day, 365 days a year, performing standard life support maneuvers on the scene or on the road. 2.3. Population Eligible patients were recruited from among all phone requests for assistance during the study period. Inclusion criteria were age over 18 years and being transported in ALS to the ED of the reference hospital after the initial evaluation and life support maneuvers on the scene. We excluded patients in cardiorespiratory arrest or with lesions incompatible with life, pregnant women, people evacuated by other means of transport (e.g., basic life support) or discharged in situ. Also, we excluded from the present study the following cases: Impossibility of obtaining informed consent at the scene or at the hospital; lack of exactness in the patient data; cases with evident physical risk at the scene, like people with psychiatric problems, attacks, armed incidents, and accidents of any etiology with ongoing risks. 2.4. Study Protocol The review protocol of this study was registered with ICTRP (doi.org/10.1186/ISRCTN17676798). The main outcome variable was early hospital mortality (within 48 h) from any cause—globally and by stratified groups—according to the NEWS2 estimated risk band. Patients discharged prior to 48 h (dead or alive in this interim) and those who died before the arrival of the EMS were not included in the study. The EMS collects all clinical data necessary to perform the NEWS2 as a standard procedure. Based on the history, exploration, and complementary tests and, depending on the type of incident, they decide the best strategy for each case accordingly with the current management guidelines for the pathology in emergencies. In addition, for this study, the determination of pLA was introduced in all ALS participating in the study, but since it was an observational study, the value of pLA was not taken into account for clinical decision-making. All the variables considered in the present work were recorded at the event site or during transportation by the EMS. The NEWS2 calculation was performed according to the recommendations of The Royal College of Physicians of London [ 6 ]. The NEWS2 analyzes seven clinical parameters: Respiratory rate, oxygen saturation, use of supplemental oxygen, heart rate, systolic blood pressure, temperature, and level of consciousness ( Table 1 ). Partial scores for each category are added to obtain an overall score. Depending on this score’s value, the risk of mortality was stratified in the following way: 1–4 points as ‘low risk’, score of 3 in any individual parameter as ‘low-medium risk’, aggregate score 5–6 as ‘medium risk’, and aggregate score of 7 or more as ‘high risk’ [ 6 ]. Respiratory rate was determined by direct observation by counting respiratory cycles in one minute. Oxygen saturation, systolic blood pressure, and heart rate were measured with the LifePAK ® 15 defibrillator monitor (Physio-Control, Inc., Redmond, WA, USA). Temperature was determined with the ThermoScan ® PRO 6000 tympanic thermometer (Welch Allyn, Inc, Skaneateles Falls, NY, USA). EMS also recorded both the use of supplemental oxygen at their arrival to the event site and the patient mental state (Glasgow Coma Scale (GCS) of less than 15 points or new confusion en route ). GCS was converted to the AVPU scale by considering GCS < 15 as V, P, or U categories of the AVPU [ 23 ], as shown in Table 1 . Blood, and therefore lactate, were obtained from all the patients in the study through a venous line, which was necessary in all cases. An Accutrend Plus measuring device (Roche Diagnostics, Mannheim, Germany) with a measuring range of 0.8–21.7 mmol/L was used to determine pLA values. The protocol for obtaining the pLA involves five phases. First, the Accutrend Plus device is turned on, the test strip is inserted, and the verification code on the screen is checked against the code of the reagent canister, as well as the expiration date. Second, blood is taken from the vein with a 1-mL syringe. Third, between 15 μL and 40 μL of blood is deposited on the test strip inside the Accutrend Plus. Fourth, the lid is closed, and the pLA value in mmol/L appears on the screen within 60 s. Then, the lid is opened, the reagent removed, and the device cleaned. The time taken from the blood sampling to its placement in the device should not exceed 1 min. To guarantee the traceability of all analyses, we recorded all reagents used in the study: Lot number, expiration date, and verification code. All Accutrend Plus devices used in the study were calibrated by the researchers from each participating center every 25 determinations using the Accutrend ® BM-Control-Lactate control solution (Roche Diagnostics, Mannheim, Germany). 2.5. Data Abstraction Prior to the field phase, all members of the research team received specific training about the standardized way of obtaining the necessary data for the calculation of the NEWS2 [ 6 ]: Use, maintenance, and calibration of electromedical equipment; blood extraction protocol; and pLA determination. All data were recorded in a standardized case form (standard clinical history used by the EMS). During the first EMS contact with the patient, the ERN recorded: Administrative data; times of arrival, assistance, and evacuation; reason for calling according to the Advanced Medical Priority Dispatch System [ 24 , 25 ]; the set of vital signs (respiratory rate, oxygen saturation, use of supplemental oxygen, heart rate, systolic blood pressure, temperature, and level of consciousness); and the pLA value. With the whole set of vital signs, the total NEWS2 score was obtained and the risk of mortality was finally stratified [ 6 ]. Forty-eight hours after the index event, an associated researcher from each hospital reviewed the electronic medical record through the database of the public health system (JIMENA-SACYL) and obtained the hospital outcomes: need for admission and/or intensive care unit (ICU) and early hospital mortality (within 48 h). Only mortality was used for the analysis, and the other outcomes were used only for descriptive purposes. To guarantee an exact link of the data between the EMS history and the electronic history in each case, the necessary linking criteria were date, time of arrival, ALS code, name and surname, sex, and age. 2.6. Data Analysis All patient data were recorded electronically in a database created specifically for this purpose. The case registration form was tested to eliminate ambiguous elements and to validate the data collection instrument. Categorical variables were expressed as number of patients and percentage (%), continuous variables were expressed as median and interquartile range (IQR) after normal distribution was discarded by a Shapiro–Wilk test. Among all registered parameters, the variables used in the analyses were, as the outcome variable: mortality within two days, and as the predictor variables: NEWS2 and pLA. None of the variables presented missing data. The statistical comparison of the cohort characteristics between groups and for each variable was performed using Student’s t -test or Chi-square test when required [ 26 ]. A two-step sequential procedure ( Figure 1 a) was followed for the analysis of the data. In the first step, an assessment of the obtained NEWS2 classification against the outcome (mortality risk) through the AUC of the ROC for all the patients was performed and, following the recommendations of the Royal College of Physicians of London, the whole cohort was divided in four groups according to the obtained NEWS2 score. This first evaluation allows not only checking the NEWS2 stratification, but also splitting the cohort in four risk groups. In the second step of the procedure, on each of the obtained groups, a new evaluation of mortality risk was performed using both the pLA levels, and, independently, the NEWS2 again. This second-step NEWS2 and pLA scores applied on each of the previously obtained groups were not combined into a single score, but they were instead considered separately in order to compare their performance regarding mortality. In this way, both systems were applied to each risk group (low, low-medium, medium, and high) to determine their capability of predicting mortality, and, subsequently, their corresponding results were compared. The validity of NEWS2 and pLA in the four groups was assessed by the AUC of the ROC curve for predicting mortality within two days. In particular, the NEWS2 value or pLA levels were used in a logistic regression model to predict the probability of mortality given the value or levels of individual patients. Then, to evaluate the discrimination between outcomes (deceased or alive,) the AUC of the ROC curve was used. In addition to the AUC, a 95% confidence interval (95% CI) and a p -value corresponding to the comparison against the chance level (AUC = 0.5) were calculated. The adjusted AUC was estimated as an internal validation procedure computed with 300 stratified bootstrap replicates, which is the recommended method for a predictive logistic regression model validation [ 27 ]. The database use for the calculations can be found in the supplementary data . Further details of the predictive model were also estimated including the odds ratios of pLA and NEWS2. A statistical comparison between the corresponding AUCs of both variables for each group was finally obtained. All statistical analyses were performed using our own codes and base functions in R, version 3.5.1 ( http://www.R-project.org ; the R Foundation for Statistical Computing, Vienna, Austria). 3. Results 3.1. Patients In the study period, 5488 cases were examined for eligibility and 3081 participants met the inclusion criteria ( Figure 1 ). Median age was 69 years (Interquartile range (IQR) 54–81 years), and 1269 (41.2%) were women. Demographic characteristics and their statistical differences are described in Table 2 . The two-day mortality was 4.4% (137 cases), most commonly of cardiovascular origin (46 cases, 33.5%). The differences between survivors and nonsurvivors were significant in all the parameters that make up the NEWS2, such as it is the case of pLA or the need for ICU (71 cases, 51.8%) ( Table 2 ). Medical pathologies (2736 cases, 88.8%) far exceeded trauma cases (345 cases, 11.2%). Table 3 shows the reasons for requesting assistance. 3.2. Patient Classification and Global NEWS2 Performance Before splitting the sample in the risk groups, the NEWS2 performance to predict mortality was evaluated presenting an AUC of 0.859 (95% CI: 0.82–0.89; p < 0.001; Figure 2 a). The internally validated AUC was 0.859 (95% CI: 0.85–0.86). As can be seen in Figure 2 b, the highest NEWS2 values correspond to an increase in mortality within two days, also shown by the predicted probability trend line. Following the recommendations of The Royal College of Physicians of London, patients were divided into four groups according to the risk of mortality ( Table 4 ): Low (1656 cases, 8 nonsurvivors), low-medium (139 cases, 1 nonsurvivor), medium (483 cases, 23 nonsurvivors), and high (803 cases, 105 nonsurvivors). 3.3. Comparison of Mortality Discrimination Derived from pLA and NEWS2 The AUCs of the pLA and the NEWS2 for each risk group obtained in the step one of the procedure—initial NEWS2 stratification—are shown in Figure 3 . For the groups of low, low-medium and medium mortality risk, the scale derived from the implementation of the pLA improved the results of NEWS2 discrimination, as evidenced by the results of pLA: AUC 0.911 (95% CI: 0.87–0.95; p < 0.001; Figure 3 a), 0.913 (95% CI: NA–NA; p = 0.07; Figure 3 c), and AUC 0.820 (95% CI: 0.76–0.88; p < 0.001; Figure 3 e); and for NEWS2: AUC 0.568 (95% CI: 0.38–0.75; p = 0.24; Figure 3 b), 0.5 (95% CI: NA–NA; p = 1; Figure 3 d), and AUC 0.525 (95% CI: 0.42–0.62; p = 0.31; Figure 3 f). In contrast, for the case of the high-risk group, the implementation of the pLA was nearly similar to NEWS2, that is, 0.762 (95% CI: 0.71–0.80; p < 0.001; Figure 3 g), and 0.756 (95% CI: 0.70–0.80; Figure 3 h), respectively. The comparison of AUCs between pLA and NEWS2 showed statistically significant differences between AUCs of low- ( p < 0.001), low-medium- ( p < 0.001), and medium-risk ( p < 0.001) groups but not for the high-risk group ( p = 0.86). In all cases, the odds ratios of pLA were statistically significant, with values of 1.29 for low-risk and 1.15 for medium- and high-risk groups ( Table 5 ), except for low-medium, but for NEWS2, only high-risk presented a significant value of 1.42 ( Table 5 ). Both tables present further measures of both scores. Additionally, in order to exclude those patients with altered mental status, we evaluated the performance of NEWS2 and pLA in patients with NEWS2 < 3. Again, the pLA outperformed NEWS2, AUC 0.908 (95% CI: 0.856–0.96; p < 0.001) and 0.555 (95% CI: 0.215–0.896; p = 0.34), respectively. The comparison of AUCs showed statistically significant differences ( p < 0.02). Similarly, if we consider the cutoff value for patients with NEWS2 < 3 as a threshold to determine the mortality, our results showed that all deaths occurred in patients with pLA > 4 mmol/L. Likewise, this value was similar to the one found in low-risk group ( Table 5 ). In this sense, further investigation on the relationship of that pLA nonmortality can be seen in Table 6 . This table shows the percentage of mortality in each group that resulted from the combination of NEWS2 above or below 3 and pLA above or below 4 mmol/L, and also highlights the low percentage of mortality for those patients with NEWS2 > 3 but also with less than 4 mmol/L. 4. Discussion In this prospective, multicenter study, we evaluated the ability of pLA to increase the prognostic accuracy of the NEWS2 for determining early mortality. We found that after performing a stratification of the risk of mortality provided by the NEWS2, a subsequent pLA measurement helps to discriminate more efficiently the risk of patients categorized as low risk. It is common to find studies that analyze the use of EWS and lactate in people with acute disease [ 18 , 19 , 28 ] and studies that specifically analyze the association between the NEWS2 and lactate [ 20 , 21 , 29 , 30 ]. However, it is rather uncommon to find studies focused on the prehospital context [ 31 , 32 , 33 ], especially dealing with the use of the pLA for a further evaluation of risk groups stratified by the NEWS2. The regular assessment of the risk of mortality in patients with acute disease and the stratification of the risk offered by the NEWS2 provides the EMS with a more precise knowledge of the situation [ 34 , 35 ], it can helps in setting treatment goals, and even it can guide them toward the most appropriate destination center. Therefore, risk stratification can help in decision-making at critical moments. The current recommendations of the Royal College of Physicians of London [ 6 ] set thresholds and triggers. An aggregate score of 7 or more indicates high risk that demands the response of the critical care team [ 36 ]. With this strict criterion for activating the emergency response, health systems ensure that no ill person is at risk of mortality and of suffering SAEs. The NEWS2 has a high sensitivity in patients with medium and high risk, and its clinical utility is certainly undebatable. Our study shows that by incorporating a subsequent assessment of the pLA, a better characterization of the risk of mortality in patients with low risk is achieved. In this way, care professionals may know in advance the severity of the condition they are confronting and the actual need for evacuation, which certainly may facilitate the decision-making process [ 9 , 37 ]. The use of point-of-care testing, and specifically pLA, is becoming widespread among the EMS [ 11 , 38 ] because it provides a robust clinical and prognostic utility with high reliability [ 39 ]. The technical possibility of performing bedside analytics allows the incorporation of these devices into standard procedures of EMS, clearly helping in decision-making. Our data indicate that a pLA less than 4 mmol/L in people with acute disease, categorized with low risk, but also for those with NEWS2 < 3, indicates a minimal risk of mortality. In contrast, a pLA greater than 4 mmol/L, despite a low risk, is associated with a significant increase in mortality, which it was also seen for patients with NEWS2 > 3, a fact that should be taken into account by professionals when predicting early SAEs, even in those a priori less serious situations [ 40 , 41 ]. The NEWS2 is easy to use, validated, and widely implemented. Likewise, measuring pLA has become easier and cheaper in the last years. For both parameters, their clinical utility as a bedside tool is undebatable. The portability of the NEWS2 and pLA makes their isolated or combined use an excellent tool for EMS either at the scene or on the road. In the prehospital context, professionals must make rapid and critical decisions, even with little data at hand. After a brief history and rapid examination and guided by few diagnostic tests, the objective must be decided according to the management guidelines of each pathology. Both the objective and a structured clinical evaluation are the main tasks the EMS should perform. The uses of EWS and point-of-care testing procedures could be included in their routine. In this case, scores certainly may be of help. Strength and Limitations The strength of the present study rests mainly in the methodology itself, as it is a multicenter prospective study with an extensive though very homogeneous cohort of participants (based on restrictive inclusion criteria). Although all personnel are professionals with extensive experience in the prehospital activity and received prior training, the work presented here possesses some limitations. On the one hand, patients’ selection bias exists because they were selected based on the opportunity criteria in a specific period of time. Also, by including only patients evaluated and evacuated in ALS, a high number of older adults were involved. This fact nonetheless reflects the target population of our geographic area, and it is in line with similar studies [ 9 ]. On the other hand, because data extraction was done on a nonblinded procedure, the cases were only considered if the mortality occurred—due to any cause—within the hospital and within the first 48 h after EMS care, in order to minimize the selection bias. The principal investigator made monthly visits to all ALS and all ED to verify the correct implementation of the research protocol with the objective to resolve potential discrepancies. The principal investigator reviewed 50% of the sample data and all cases of early mortality. 5. Conclusions The risk stratification provided by the NEWS2 can be improved by incorporating pLA determination to more accurately predict the risk of mortality in patients with low risk. Supplementary Materials The following are available online at https://www.mdpi.com/2077-0383/9/4/1156/s1 , Table S1: Database used in the present work. Author Contributions Conceptualization, F.M.-R. and R.L.-I.; methodology, J.L.M.-C., A.S.-G and J.F.D.B.; software, A.S.-G.; formal analysis, G.J.O. and A.S.-G.; investigation, C.d.P.V. and M.Á.C.V.; resources, J.L.M.-C., and C.d.P.V.; data curation, M.Á.C.V.; writing—original draft preparation, F.M.-R.; writing—review and editing, R.L.-I.; visualization, C.d.P.V.; supervision, G.J.O.; project administration, F.M.-R. All authors have read and agreed to the published version of the manuscript. Funding This research was funded by Gerencia Regional de Salud de Castilla y León (Spain), grant number GRS 1678/A/18. Conflicts of Interest The authors declare no conflict of interest. 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AUC: Area under the curve; BLS: Basic life support; NEWS2: National Early Warning Score 2; pLA: Prehospital lactate; ROC: Receiver operating characteristic. Figure 1. ( a ) The two-step analysis procedure. ( b ) Epidemiology diagram showing analysis population by groups derived from the risk stratification provided by the NEWS2. AUC: Area under the curve; BLS: Basic life support; NEWS2: National Early Warning Score 2; pLA: Prehospital lactate; ROC: Receiver operating characteristic. Figure 2. ( a ) Receiver operational characteristic (ROC) by NEWS2 for early mortality. The bold line shows the value of the ROC curve and the orange shading is the 95% confidence interval. In the center of the graph is the area under the curve (AUC), its 95% confidence interval and the p -value of the comparison against the null hypothesis (AUC = 0.5). ( b ) Probability of death based on the value of NEWS2 for early mortality. The bar graph shows the number of patients in the whole cohort for each scale value (survivors in blue and nonsurvivors in red). The trend line shows the estimated probability of death. Figure 2. ( a ) Receiver operational characteristic (ROC) by NEWS2 for early mortality. The bold line shows the value of the ROC curve and the orange shading is the 95% confidence interval. In the center of the graph is the area under the curve (AUC), its 95% confidence interval and the p -value of the comparison against the null hypothesis (AUC = 0.5). ( b ) Probability of death based on the value of NEWS2 for early mortality. The bar graph shows the number of patients in the whole cohort for each scale value (survivors in blue and nonsurvivors in red). The trend line shows the estimated probability of death. Figure 3. Receiver operational characteristic (ROC) of pLA for early mortality based on the stratification of the risk of mortality. ( a ) Low risk, ( c ) low-intermediate risk, ( e ) intermediate risk, ( g ) high risk; and ROC of NEWS2 for early mortality based on the stratification of the risk of mortality ( b ) low risk, ( d ) low-intermediate risk, ( f ) intermediate risk, ( h ) high risk. The bold line shows the value of the ROC curve and the orange shading is the 95% confidence interval. In the center of the graph is the area under the curve (AUC), its 95% confidence interval, and the p -value of the comparison against the null hypothesis (AUC = 0.5). Figure 3. Receiver operational characteristic (ROC) of pLA for early mortality based on the stratification of the risk of mortality. ( a ) Low risk, ( c ) low-intermediate risk, ( e ) intermediate risk, ( g ) high risk; and ROC of NEWS2 for early mortality based on the stratification of the risk of mortality ( b ) low risk, ( d ) low-intermediate risk, ( f ) intermediate risk, ( h ) high risk. The bold line shows the value of the ROC curve and the orange shading is the 95% confidence interval. In the center of the graph is the area under the curve (AUC), its 95% confidence interval, and the p -value of the comparison against the null hypothesis (AUC = 0.5). Table 1. National Early Warning Score 2 (NEWS2). Table 1. National Early Warning Score 2 (NEWS2). NEWS2 3 2 1 0 1 2 3 Pulse (bpm) ≤40 41–50 51–90 91–110 111–130 ≥131 BR (bpm) ≤8 9–11 12–20 21–24 ≥25 T (°C) ≤35 35.1–36 36.1–38 38.1–39 ≥39.1 SBP (mmHg) ≤90 91–100 101–110 111–219 ≥220 SpO 2 (%) Scale 1 ≤91 92–93 94–95 ≥96 SpO 2 (%) Scale 2 1 ≤83 84–85 86–87 88–92 ≥93 air 93–94 Oxygen 95–96 Oxygen ≥97 Oxygen Air oxygen Oxygen Air AVPU (scale) A V, P, U 1 In patients with hypercapnic respiratory insufficiency, scale 2 should be used to weight the oxygen saturation score. SBP: Systolic blood pressure; BR: Breathing rate; SpO 2 : Oxygen saturation; AVPU: Alert, verbal, pain, unresponsive: T: Temperature. Reproduced from The Royal College of Physicians. National Early Warning Score (NEWS) 2: Standardizing the assessment of acute-illness severity in the NHS. Updated report of a working party. London: RCP, 2017 [ 6 ]. Table 2. Demographic, prehospital, and hospital characteristics of study subjects (death statistics refer to mortality rates in less than 48 h). Table 2. Demographic, prehospital, and hospital characteristics of study subjects (death statistics refer to mortality rates in less than 48 h). Characteristic 1 Total Survivors Non-Survivors p -Value Number ( n (%)) 3081 (100) 2944 (95.6) 137 (4.4) Age (years) 69 (54–81) 69 (53–81) 80 (65–87) 0.001 2 Female 1269 (41.2) 1218 (41.4) 51 (37.2) 0.335 3 Isochronous (Minutes) Arrival time 10 (8–13) 10 (8–13) 10 (8–15) 0.184 2 Support time 28 (22–34) 28 (22–34) 32 (25–39) 0.001 2 Transfer time 10 (7–14) 10 (7–13) 10 (7–18) 0.039 2 Initial Evaluation NEWS 2 (points) 4 (2–7) 4 (2–6) 11 (7–13) 0.001 2 Breathing rate (bpm) 17 (14–24) 17 (14–22) 23 (14–34) 0.001 2 Supplemental oxygen 389 (12.6) 343 (11.7) 46 (33.6) 0.001 2 Oxygen saturation (%) 96 (93–98) 96 (93–98) 83 (72–93) 0.001 2 Heart rate (bpm) 85 (70–104) 84 (70–102) 97 (71–121) 0.009 2 SBP (mmHg) 137 (118–155) 137 (119–155) 124 (93–153) 0.002 2 Temperature (°C) 36.3 (36.0–36.8) 36.3 (36.0–36.8) 36.0 (35.1–37.0) 0.014 2 GCS (3–15 points) 15 (15–15) 15 (15–15) 11 (3–15) 0.001 2 pLA (mmol/L) 2.9 (2.0–4.0) 2.8 (1.9–3.8) 5.1 (4.3–7.3) 0.001 2 Hospital Outcomes Inpatients 1718 (55.8) 1581 (53.7) 137 (100) 0.001 2 ICU 526 (17.1) 455 (15.5) 71 (51.8) 0.001 2 1 Values expressed as total number (fraction) and medians (25th percentile–75th percentile) as appropriate. 2 The p -values were calculated with Mann–Whitney U-test. 3 The p -values were calculated with Chi-square test. NEWS 2: National Early Warning Score 2; SBP: Systolic blood pressure; GCS: Glasgow coma scale; pLA: Point-of-care lactate; ICU: Intensive care unit. Table 3. Distribution of cases according to the Advanced Medical Priority Dispatch System (death statistics refer to mortality rates in less than 48 h). Table 3. Distribution of cases according to the Advanced Medical Priority Dispatch System (death statistics refer to mortality rates in less than 48 h). Pathologies Total Survivors Non-Survivors Abdominal Pain/Problems 176 (5.7) 166 (5.6) 10 (7.3) Allergies (Reactions) 33 (1.1) 33 (1.1) 0 Animal Bites/Attacks 3 (0.1) 3 (0.1) 0 Assault/Sexual Assault/Stun Gun 2 (0.1) 1 (0) 1 (0.7) Breathing Problems 333 (10.8) 311 (10.6) 22 (16.1) Burns (Scalds)/Explosions 7 (0.2) 6 (0.2) 1 (0.7) Carbon Monoxide/Inhalation 12 (0.4) 12 (0.4) 0 Chest Pain 593 (19.2) 579 (19.7) 14 (10.2) Choking 17 (0.6) 12 (0.4) 5 (3.6) Convulsions/Seizures 185 (6.0) 185 (6.3) 0 Diabetic Problems 37 (1.2) 36 (1.2) 1 (0.7) Electrocution/Lightning 2 (0.1) 2 (0.1) 0 Falls 59 (1.9) 57 (1.9) 2 (1.5) Headache 64 (2.1) 64 (2.2) 0 Heart Problems/AICD 381 (12.4) 349 (11.9) 32 (23.4) Heat/Cold Exposure 11 (0.4) 10 (0.3) 1 (0.7) Hemorrhage/Lacerations 27 (0.9) 27 (0.9) 0 Inaccessible Incident/Entrapments 3 (0.1) 3 (0.1) 0 Overdose/Poisoning (Ingestion) 158 (5.1) 154 (5.2) 4 (2.9) Sick Person 106 (3.4) 96 (3.3) 10 (7.3) Stab/Gunshot/Penetrating Trauma 10 (0.3) 10 (0.3) 0 Stroke/Transient Ischemic Attack 301 (9.8) 290 (9.9) 11 (8.0) Traffic/Transportation Incidents 160 (5.2) 155 (5.3) 5 (3.6) Traumatic Injuries 49 (1.6) 44 (1.5) 5 (3.6) Unconscious/Fainting (Near) 352 (11.4) 339 (11.5) 13 (9.5) Values expressed as total number and percentage of mortality in parentheses; AICD: Automated Implantable Cardioverter-Defibrillator. Table 4. Characteristics of study subjects by risk groups based on the NEWS2. Table 4. Characteristics of study subjects by risk groups based on the NEWS2. Variable Mortality Risk Low Low-Medium Medium High Number 1656 (53.8) 139 (4.5) 483 (15.7) 803 (26.1) Age (years) 65 (51–78) 66 (49–79) 72 (55–83) 76 (62–84) Female 669 (52.7) 67 (5.2) 208 (16.4) 325 (25.6) pLA (mmol/L) 2.4 (1.8–3.4) 2.9 (2.0–3.8) 3.1 (2.2–4.4) 3.7 (2.6–5.1) Hospital Outcomes Inpatients 741 (44.7) 57 (41) 290 (60.0) 630 (78.5) ICU 223 (13.4) 21 (15.1) 76 (15.7) 206 (25.7) Mortality 8 (0.5) 1 (0.7) 23 (4.8) 105 (13.1) Table 5. Measures of the predictive model. Table 5. Measures of the predictive model. Mortality Risk by pLA Low Low-Medium Medium High Prev. 0.005 0.005 0.048 0.131 pLA cut-off 4.0 4.9 4.3 4.1 Se 28.3 (8.83–47.7) 50 (12.2–87.7) 30.4 (11.7–49.1) 28.4 (11.5–45.4) Sp 86.4 (73.1–99.6) 71.2 (45.1–97.3) 81.5 (67.3–95.6) 81.0 (67.4–94.6) PPV 1.01 (0.37–1.65) 1.35 (0–3.08) 7.46 (5.25–9.67) 15.2 (10.6–19.7) NPV 99.6 (99.5–99.7) 99.5 (99.2–99.8) 96.2 (95.4–97.1) 89.4 (87.4–91.3) LR+ 2.14 (0.78–3.51) 1.97 (0–4.55) 1.66 (1.15–2.17) 1.29 (0.87–1.7) LR− 0.77 (0.58–0.95) 0.57 (0.15–1) 0.77 (0.59–0.95 0.80 (0.63–0.95 DA 86.1 (73–99.2) 71.1 (45.3–96.8) 79.1 (66.4–91.7) 74,1 (64.3–83.9) OR 1.27 (1.12–1.45) ( p < 0.001) NS 1.15 (1.06–1.24) ( p < 0.001) 1.15 (1.10–120) ( p < 0.001) Mortality Risk by NEWS 2 Low Low-Medium Medium High Prev. 0.005 NA 0.048 0.131 NEWS2 cut-off 2 NA 5 11 Se 65 (21.9–100) NA 69.5 (0–100) 66.7 (57.2–75) Sp 40.8 (0–81.9) NA 27 (0–100) 74.6 (71.3–77.7) PPV 0.52 (0.30–0.74) NA 4.5 (1.22–7.78) 28.3 (23.1–34.3) NPV 99.6 (99.4–99.8) NA 94.8 (NA–NA) 93.7 (91.4–95.4) LR+ 1.09 (0.63–1.54) NA 0.94 (0.22–1.66) 2.63 (2.18–3.17) LR− 0.81 (0.44–1.19) NA 1.08 (NA–NA) 0.45 (0.34–0.59) DA 40.9 (18.9–81.6) NA 26.9 (0–100) 73.6 (70.4–76.5) OR NS NS NS 5.89 (3.79–9.14) ( p < 0.001) Bracketed numbers indicate 95% confidence interval. Prev: Prevalence; pLA: Prehospital lactate; Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value: NPV: Negative predictive value; LR: Likelihood ratio; OR: Odds ratio; DA: Diagnostic accuracy. Low risk: Aggregate score 0–4. Low-medium risk: Score of 3 in any individual parameter. Medium risk: Aggregate score 5–6. High risk: Aggregate score 7 or more. Table 6. Mortality of groups resulted from the combination of NEWS2 above and below 3 and prehospital lactate above and below the cutoff (4 mmol/L). Table 6. Mortality of groups resulted from the combination of NEWS2 above and below 3 and prehospital lactate above and below the cutoff (4 mmol/L). Survivors Non-Survivors Odd Ratios NEWS2 < 3 pLA < 4 944 (100%) 0 (0%) * pLA > 4 158 (97.5%) 4 (2.5%) NEWS2 > 3 pLA < 4 1075 (98.5%) 17 (1.5%) 15.75(9.27–28.32) p < 0.001 pLA > 4 449 (80%) 112 (20%) Bracketed numbers indicate 95% confidence interval. pLA: Prehospital lactate; * cannot be calculated because of 0 cases in one group. Martín-Rodríguez, F.; López-Izquierdo, R.; Delgado Benito, J.F.; Sanz-García, A.; del Pozo Vegas, C.; Castro Villamor, M.Á.; Martín-Conty, J.L.; Ortega, G.J. Prehospital Point-Of-Care Lactate Increases the Prognostic Accuracy of National Early Warning Score 2 for Early Risk Stratification of Mortality: Results of a Multicenter, Observational Study. J. Clin. Med. 2020, 9, 1156. https://doi.org/10.3390/jcm9041156 Martín-Rodríguez F, López-Izquierdo R, Delgado Benito JF, Sanz-García A, del Pozo Vegas C, Castro Villamor MÁ, Martín-Conty JL, Ortega GJ. Prehospital Point-Of-Care Lactate Increases the Prognostic Accuracy of National Early Warning Score 2 for Early Risk Stratification of Mortality: Results of a Multicenter, Observational Study. Journal of Clinical Medicine. 2020; 9(4):1156. https://doi.org/10.3390/jcm9041156 Chicago/Turabian Style Martín-Rodríguez, Francisco, Raúl López-Izquierdo, Juan F. Delgado Benito, Ancor Sanz-García, Carlos del Pozo Vegas, Miguel Ángel Castro Villamor, José Luis Martín-Conty, and Guillermo J. Ortega. 2020. "Prehospital Point-Of-Care Lactate Increases the Prognostic Accuracy of National Early Warning Score 2 for Early Risk Stratification of Mortality: Results of a Multicenter, Observational Study" Journal of Clinical Medicine9, no. 4: 1156. https://doi.org/10.3390/jcm9041156
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Materials | Free Full-Text | Optimal Dimensioning of Retaining Walls Using Explainable Ensemble Learning Algorithms This paper develops predictive models for optimal dimensions that minimize the construction cost associated with reinforced concrete retaining walls. Random Forest, Extreme Gradient Boosting (XGBoost), Categorical Gradient Boosting (CatBoost), and Light Gradient Boosting Machine (LightGBM) algorithms were applied to obtain the predictive models. Predictive models were trained using a comprehensive dataset, which was generated using the Harmony Search (HS) algorithm. Each data sample in this database consists of a unique combination of the soil density, friction angle, ultimate bearing pressure, surcharge, the unit cost of concrete, and six different dimensions that describe an optimal retaining wall geometry. The influence of these design features on the optimal dimensioning and their interdependence are explained and visualized using the SHapley Additive exPlanations (SHAP) algorithm. The prediction accuracy of the used ensemble learning methods is evaluated with different metrics of accuracy such as the coefficient of determination, root mean square error, and mean absolute error. Comparing predicted and actual optimal dimensions on a test set showed that an R2 score of 0.99 could be achieved. In terms of computational speed, the LightGBM algorithm was found to be the fastest, with an average execution speed of 6.17 s for the training and testing of the model. On the other hand, the highest accuracy could be achieved by the CatBoost algorithm. The availability of open-source machine learning algorithms and high-quality datasets makes it possible for designers to supplement traditional design procedures with newly developed machine learning techniques. The novel methodology proposed in this paper aims at producing larger datasets, thereby increasing the applicability and accuracy of machine learning algorithms in relation to optimal dimensioning of structures. Optimal Dimensioning of Retaining Walls Using Explainable Ensemble Learning Algorithms by Gebrail Bekdaş 1,* , Celal Cakiroglu 2 , Sanghun Kim 3 and Zong Woo Geem 4,* * Authors to whom correspondence should be addressed. Materials 2022 , 15 (14), 4993; https://doi.org/10.3390/ma15144993 Received: 30 June 2022 / Revised: 8 July 2022 / Accepted: 15 July 2022 / Published: 18 July 2022 (This article belongs to the Special Issue Modeling and Testing of Reinforced Concrete or Composite Structures Using Advanced New Materials ) Abstract This paper develops predictive models for optimal dimensions that minimize the construction cost associated with reinforced concrete retaining walls. Random Forest, Extreme Gradient Boosting (XGBoost), Categorical Gradient Boosting (CatBoost), and Light Gradient Boosting Machine (LightGBM) algorithms were applied to obtain the predictive models. Predictive models were trained using a comprehensive dataset, which was generated using the Harmony Search (HS) algorithm. Each data sample in this database consists of a unique combination of the soil density, friction angle, ultimate bearing pressure, surcharge, the unit cost of concrete, and six different dimensions that describe an optimal retaining wall geometry. The influence of these design features on the optimal dimensioning and their interdependence are explained and visualized using the SHapley Additive exPlanations (SHAP) algorithm. The prediction accuracy of the used ensemble learning methods is evaluated with different metrics of accuracy such as the coefficient of determination, root mean square error, and mean absolute error. Comparing predicted and actual optimal dimensions on a test set showed that an R 2 score of 0.99 could be achieved. In terms of computational speed, the LightGBM algorithm was found to be the fastest, with an average execution speed of 6.17 s for the training and testing of the model. On the other hand, the highest accuracy could be achieved by the CatBoost algorithm. The availability of open-source machine learning algorithms and high-quality datasets makes it possible for designers to supplement traditional design procedures with newly developed machine learning techniques. The novel methodology proposed in this paper aims at producing larger datasets, thereby increasing the applicability and accuracy of machine learning algorithms in relation to optimal dimensioning of structures. Keywords: machine learning ; optimization ; structural design 1. Introduction Retaining walls are a ubiquitous element in structural design. Due to their relatively large dimensions, optimizing their dimensions can lead to significant gains with construction costs. Furthermore, designing with minimum dimensions has certain advantages for CO 2 emissions because of using the minimum amount of cement. Therefore, the application of advanced methodologies of optimization in the design of retaining walls has economic and environmental benefits. Many newly developed optimization techniques have been used for structural optimization in recent years. Gomes [ 1 ] applied the particle swarm optimization technique to the mass optimization of steel trusses under frequency constraints. Similarly, Dede [ 2 ] analyzed the weight minimization of steel trusses using the teaching–learning-based optimization algorithm. Bekdaş et al. [ 3 ] used several metaheuristic optimization algorithms in the minimum total potential energy analysis of steel trusses. Bekdaş [ 4 ] applied the applications of harmony search, flower pollination, and teaching–learning-based optimization algorithms to minimizing the total construction cost associated with axially symmetric cylindrical reinforced concrete walls. Ocak et al. [ 5 , 6 ] optimized a tuned liquid damper device, which was used for lateral displacement control of structures using the adaptive harmony search algorithm. Ulusoy [ 7 ] applied the teaching–learning-based optimization algorithm to the problem of the fire-resistant design of timber-based roof structures. Cakiroglu et al. [ 8 , 9 ] showed that the social spider algorithm could affect the cost minimization problem for concrete-filled steel tubular columns. The optimum design of retaining walls has been investigated using various metaheuristic algorithms including the non-dominated sorting genetic algorithm (NSGA-II) [ 10 ], flower pollination algorithm [ 11 ], gravitational search algorithm [ 12 ], and harmony search algorithm [ 13 , 14 , 15 ]. In addition to various optimization algorithms, the application of machine learning techniques in structural design has been increasingly reported in the literature. Feng et al. [ 16 ] developed an XGBoost-SHAP machine learning model which estimates the shear strength of reinforced concrete shear walls. In their study, the database, which consisted of 434 samples, was split into a training and a test set in a 70% to 30% ratio. This split ratio is adopted by the majority of the studies in this field and it is based on the optimum split ratio established by Mangalathu et al. [ 17 ]. Somala et al. [ 18 ] showed that in the fundamental period estimation of masonry infilled reinforced concrete frames, Ensemble Learning Techniques such as Random Forest and XGBoost could outperform the existing empirical predictive models available in the literature. Ahmed et al. [ 19 ] developed a novel long short-term memory network with overlapping data for the accurate prediction of earthquake-induced damage in ductile and non-ductile frame structures. Ni et al. [ 20 ] generated fragility curves for buried pipelines using Lasso Regression Analysis. Bekdaş et al. [ 21 ] demonstrated the high accuracy of different Ensemble Learning Algorithms in predicting the optimal wall thickness of reinforced concrete cylindrical walls. Cakiroglu et al. [ 22 ] developed predictive models using Ensemble Learning Algorithms to estimate the axial load-carrying capacity of FRP-reinforced concrete columns. The current paper deals with optimizing six key dimensions which define the dimensioning of a retaining wall. These dimensions are the length of the heel (X1), length of the toe (X2), the thickness of the stem at the top of the wall (X3), the thickness of the stem at the bottom of the wall (X4), the thickness of the foundation of the wall (X5), and the stem height of the wall (H). For each of them, a separate predictive model has been developed using four different Ensemble Learning Algorithms. Ensemble Learning Techniques have been demonstrated to have superior performance in terms of prediction accuracy in recent years in comparison to traditional methods of structural performance prediction. The dataset needed to train the predictive models has been created using the Harmony Search Algorithm. More than seventy thousand data samples have been created, where each one of these data points corresponds to an optimum design configuration. Every data sample in this dataset contains, in addition to the six geometric variables which define the retaining wall geometry, the soil density ( γ ), surcharge loading (q), soil friction angle ( ϕ ), the unit cost of concrete (C c ), and the soil bearing capacity (q z ). Optimal dimensioning of retaining walls can lead to significant gains in terms of cost and environmental protection. In recent years, various optimization techniques have been demonstrated for minimizing the construction cost associated with retaining walls. On the other hand, machine learning algorithms are increasingly being used in the prediction of structural performance. However, it is necessary to train these predictive algorithms using large datasets for their accuracy. The availability of large-enough datasets has been a major bottleneck in the development of accurate predictive machine learning models for structural design in the recent years. Most of the research in this area has been conducted using datasets in the order of magnitude of a thousand data samples or fewer. To overcome this limitation, the current paper demonstrates a novel technique to generate significantly larger datasets with the help of optimization algorithms. The current paper is unique in its combination of metaheuristic optimization with machine learning models to obtain predictive models that can determine optimal dimensions of a retaining wall under various loading and soil conditions. The novelty of the paper is the usage of a well-established optimization methodology for the generation of large datasets that can be used in the training of machine learning models. 2. Methods of Optimization and Predictive Model Development The current paper demonstrates the application of the harmony search algorithm in generating large datasets consisting of optimum design configurations. These design configurations consist of six key geometric variables which define the geometry of a retaining wall in addition to soil properties, concrete unit cost, and applied surcharge load. The variables of retaining wall geometry are shown in Figure 1 . After generating a large dataset with more than seventy thousand combinations of design variables, four different machine learning models are trained based on this dataset. The following sections describe optimization and machine learning techniques. Figure 1. Retaining wall dimensions. 2.1. Harmony Search Algorithm The application of metaheuristic optimization algorithms to structural optimization is an active area of research. Among a large number of metaheuristic algorithms, the harmony search (HS) algorithm is one of the most widely used and established techniques, and applied to numerous areas such as structural design [ 23 ], water network design [ 24 ], flood model calibration [ 25 ], economic load dispatch [ 26 ], concrete mix proportion design [ 27 ], chaotic systems [ 28 ], timetabling [ 29 ], weapon target assignment [ 30 ], stock price prediction [ 31 ], mobile network security [ 32 ], COVID-19 detection from CT scans [ 33 ], and subway ventilation [ 34 ]. The technique is based on the incremental improvement of an initial population of randomly generated solution candidates, also called the harmony memory matrix. In the case of cost optimization of the retaining wall, the solution candidates are vectors consisting of variables such as the wall geometry, soil properties, unit cost of material used in the retaining wall construction, and the external loads, as shown in Equation (1) where harmony memory size (HMS) denotes the size of the population of candidate solution vectors. H M = X 1 1 X 2 1 X 3 1 X 4 1 X 5 1 H 1 q z 1 q 1 γ 1 ϕ 1 C c 1 f x 1 X 1 2 X 2 2 X 3 2 X 4 2 X 5 2 H 2 q z 2 q 2 γ 2 ϕ 2 C c 2 f x 2 ⋮ ⋮ ⋮ ⋮ ⋮ ⋮ ⋮ ⋮ ⋮ ⋮ ⋮ ⋮ X 1 H M S X 2 H M S X 3 H M S X 4 H M S X 5 H M S H H M S q z H M S q H M S γ H M S ϕ H M S C c H M S f x H M S (1) In Equation (1), each row of the harmony memory matrix (HM) contains the components of a candidate solution vector. The last column of the HM contains the output of a function f that takes a candidate solution vector as its argument and returns the performance of the solution vector. In the case of cost optimization, the output of f is the total cost of material used in constructing the retaining wall. Based on their performances, the solution vectors are ranked, and the best- and worst-performing members of the population are determined. In each HS iteration, the solution vectors are updated according to the steps shown in Equations (2)–(5). k = int ( rand · HMS ) , rand ∈ ( 0 , 1 ) (2) x i , new = x i , min + rand · ( x i , max − x i , min ) , if HMCR > rand (3) x i , new = x i , k + rand · PAR · ( x i , max − x i , min ) , if HMCR ≤ rand (4) HMCR = 0.5 ( 1 − i max ( i ) ) , PAR = 0.05 ( 1 − i max ( i ) ) (5) HMCR and PAR in Equations (2)–(5) are the harmony memory consideration rate and the pitch adjustment rate, respectively. After each modification step, the newly generated solution vectors are ranked against the existing vectors. Among these vectors, the ones that perform better than the vectors of the previous iteration replace those worse-performing vectors. In the process of generating new solution candidate vectors, the constraints of optimization are regarded based on design codes for retaining walls so that the new design has enough capacity to resist the applied loads. The details of the HS algorithm and its different variants can be found in [ 35 ]. 2.2. Machine Learning Methodologies The database of optimum design combinations generated through the HS algorithm has been used in training predictive models. The design variables included in this dataset and their ranges are shown in Figure 2 , where the values that each design variable takes are split into four different subgroups. For each one of these groups, the total number of samples belonging to that group is written inside the horizontal bars and the subgroup ranges are written above the subgroup boundaries. In Figure 2 , the length of a subgroup indicates the percentage of the samples belonging to that group inside of the entire dataset. Figure 2. Design variable ranges in the dataset. Figure 2 shows the concrete unit price (C c ) ranging between 50 and 150 USD/m 3 . It can be observed that the majority of cases were within the 75–150 USD/m 3 range. The entire range of unit prices for concrete corresponds to a compressive strength of 16 to 50 MPa, which includes the compressive strengths of most commonly used concrete classes, excluding high strength concrete [ 36 , 37 ]. For the details of the correlation between the soil friction angles included in this study with the other soil properties and the soil classification, the reader is referred to [ 38 ]. The predictive models in this paper were generated using the XGBoost, Random Forest, LightGBM, and CatBoost algorithms. These models are further analyzed using the SHapley Additive exPlanations (SHAP) methodology. The following sections show a summary of the theoretical background of these methods. 2.2.1. Extreme Gradient Boosting (XGBoost) The XGBoost algorithm is a decision tree-based method that has the capability of scaling to large datasets with billions of samples. The decision tree technique starts with testing a root criterion and recursively branches into leaf nodes, testing further criteria, ultimately reaching a terminal node that contains the prediction. The algorithm controls overfitting by using a special regularization technique. The objective of the algorithm is to obtain mapping between the input vectors x i and the output values y i as shown in Equations (6) and (7), where L is the loss function, f k is a weak learner, α k is the learning rate, T is the number of leaves, w k are the leaf weights, and γ and λ are the penalty coefficients [ 16 , 39 ]. y ^ i = ϕ ( x i ) = ∑ k = 1 K α k f k ( x i ) (6) L ( ϕ ) = ∑ i ( y i − y ^ i ) 2 + ∑ k γ T + 1 2 λ | | w k | | (7) 2.2.2. Random Forest The Random Forest technique combines the predictions of an ensemble of single decision trees. The algorithm implements bagging and random feature selection techniques such that every decision tree in the ensemble is built using a bootstrap sample of the training set and the mean value of the individual tree predictions determines the overall predictive model prediction. In every node split, a random subset of features is selected for tree building. The random forest model can be summarized as in Equation (8), where m ^ j stands for a single decision tree [ 40 , 41 , 42 ]. m ^ ( x ) = 1 M ∑ i = 1 N m ^ j ( x ) (8) 2.2.3. Light Gradient Boosting Machine (LightGBM) LightGBM is another decision tree-based algorithm, where the leaf-wise generation of the predictive model enables the creation of more complex trees. This is a version of the gradient boosting algorithm with improved computational speed and better accuracy. Using the Gradient-based One-Side Sampling (GOSS) method, LightGBM can handle large datasets. The Exclusive Feature Bundling (EFB) method makes it possible to handle datasets with a large number of design features in a more efficient way compared to the basic gradient boosting decision tree [ 43 , 44 , 45 ]. 2.2.4. Categorical Gradient Boosting (CatBoost) CatBoost differentiates itself from the basic gradient boosting decision tree in that it is capable of dealing with categorical input features more efficiently. The built-in one-hot encoding capability of CatBoost can obtain target statistics from categorical features. Furthermore, the ordered boosting technique allows the CatBoost algorithm to overcome the gradient bias. Let X i = ( x i , 1 , … , x i , m ) be an input vector consisting of m design features and Y = ( Y 1 , … , Y n ) , the vector of labels. Let σ = ( σ 1 , … , σ n ) be a permutation. To reduce overfitting and use the entire dataset, the CatBoost algorithm uses a random permutation by substituting x σ p , k with the expression in Equation (9), where P is a prior value and a > 0 is its weight [ 46 , 47 ]. ∑ j = 1 p − 1 [ x σ j , k = x σ p , k ] Y σ j + a · P ∑ j = 1 p − 1 [ x σ j , k = x σ p , k ] + a (9) 2.2.5. SHapley Additive exPlanations (SHAP) The SHAP analysis is a great contribution to the explainability of the machine learning models, in that it enables a visual representation of the impact of each input variable on the predictive model outcome. Furthermore, Shapley values can measure the interdependencies between different input variables. The algorithm is based on game theory and uses the additive feature attribution, method where an output model is defined as a linear combination of simplified input vectors, as shown in Equation (10) [ 48 ]. f ( x ) = g ( x ′ ) = ϕ 0 + ∑ i = 1 M ϕ i x i ′ (10) In Equation (10), the functions f and g are the original predictive model and the explanation model, respectively. M is the total number of input variables, x is a vector of input variables, x i are the simplified input vectors, and ϕ i are the Shapley values. The Shapley values are calculated using Equation (11). Further details of the SHAP algorithm can be found in [ 49 ]. ϕ i ( f , x ) = ∑ z ′ ⊆ x ′ | z ′ | ! ( M − | z ′ | − 1 ) ! M ! [ f x ( z ′ ) − f x ( z ′ \ i ) ] (11) 3. Results In this section, the predictions of four different Ensemble Learning Algorithms are compared to the actual optimum dimensions obtained through the harmony search method. 3.1. Comparison of the Model Predictions The comparisons have been visualized for all of the six key dimensions that describe the retaining wall geometry. For each algorithm and each dimension that is being predicted, the accuracy of the predictive models has been measured using three different metrics and listed in Table 1 . In Figure 3 , Figure 4 , Figure 5 and Figure 6 , the predicted optimum dimensions are plotted against the actual optimized dimensions. It can be observed that in the plots showing the predictions for X1, X5, and H, the points representing the different configurations are within a relatively narrow band, which indicates higher accuracy of prediction. In each one of these plots, the dotted ±10% lines can be seen, which indicates a 10% deviation from a perfect match between the predicted and actual optimal dimensions. Figure 3. Comparison of the predicted and optimized dimensions using XGBoost. ( a ) X1, ( b ) X2, ( c ) X3, ( d ) X4, ( e ) X5, ( f ) H. Figure 4. Comparison of the predicted and optimized dimensions using Random Forest. ( a ) X1, ( b ) X2, ( c ) X3, ( d ) X4, ( e ) X5, ( f ) H. Figure 5. Comparison of the predicted and optimized dimensions using LightGBM. ( a ) X1, ( b ) X2, ( c ) X3, ( d ) X4, ( e ) X5, ( f ) H. Figure 6. Comparison of the predicted and optimized dimensions using CatBoost. ( a ) X1, ( b ) X2, ( c ) X3, ( d ) X4, ( e ) X5, ( f ) H. Table 1. Prediction accuracy of the machine learning models. Table 1 shows that five out of the six parameters defining the wall geometry could be accurately predicted using the ensemble learning models. Among these models in Table 1 , low R 2 values were obtained for X3, since the database used in the training of the predictive models is mostly populated with samples where the X3 value is 0.2. This distribution of the design variable values was obtained after eliminating the design configurations for which the harmony search method did not converge to an optimum result within design constraints. Taking the average value of the metrics of accuracy corresponding to different dimensions, it can be seen from Table 2 that the CatBoost model has the best performance in terms of all three accuracy metrics. CatBoost was followed by Random Forest and LightGBM, whose performances were close to each other. Lastly, the XGBoost models had the lowest accuracy among the four predictive models. Table 2. Average predictive model accuracy and performance. The Taylor diagrams in Figure 7 show the model quality by using the Pearson correlation coefficient as the metric of accuracy. The equation for the calculation of the Pearson correlation is given in Appendix A . The prediction of each model is shown with a circle and the corresponding correlation coefficient is shown on the radial grid, which ranges from 0 to 1. Furthermore, for each predictive model as well as the original dataset, the corresponding standard deviation values are calculated and shown on both the horizontal and vertical axes. From Figure 7 , it can be seen that for the design variables X1, X5, and H, the correlation coefficients were greater than 0.99 for all predictive models, which indicates excellent accuracy of prediction. For X2 and X4, the correlation values were 0.98 for all predictive models. The lowest correlation values were observed for X3 in the interval from 0.75 to 0.80, where the highest correlation values could be obtained through the CatBoost model. A summary of the predictive model performance can be observed in Table 2 , where the average values of the error metrics are listed for all the models. According to Table 2 , the CatBoost models have the highest accuracy on average. Figure 7. Taylor diagrams for the design variables. 3.2. SHAP Analysis The SHAP summary plots and feature dependence plots presented in this section provide an effective way of visualizing the impact of various design variables on the overall predictions of the machine learning models. The summary plot shown in Figure 8 is an information-rich representation of how ten different input variables affected the CatBoost model outcome for the prediction of the wall stem thickness at the bottom (X4). In Figure 8 , each dot corresponds to a different sample in the database. The dot positions along the horizontal axis are related to the SHAP value of the variable such that greater positive values indicate an increasing effect on the model prediction and negative SHAP values indicate a decreasing effect on the model output. Furthermore, the magnitude of a variable in a sample is represented with color such that greater magnitudes are shown with the shades of blue and lower values are shown with the shades of red. According to Figure 8 , the thickness of the wall foundation (X5) has the greatest impact on X4 such that increasing the X5 value also increases X4. Figure 8. SHAP summary plot for X4. The feature dependence plots in Figure 9 present further information about the interdependencies of the different input variables. Figure 9 a shows that as the value of X1 increases, the SHAP value decreases. Therefore, its impact on the model output tends to decrease. Particularly when the length of the toe (X2) has a high value, this relationship between X1 and its impact is more pronounced. From Figure 9 b, it can be observed that up to a certain value as X2 increases, its SHAP value increases regardless of the value of X5, which is the variable most dependent on X2. For X2 > 1.5, the impact of these variables decreases with its size when X5 has higher values shown with the shades of red. The relationship between the values of X5 and the impact of this variable on the model output can be observed in Figure 9 d. For X5 < 1, the value of X5 and its impact are linearly proportional regardless of the value of C c , which is the most dependent parameter on X5. Figure 9. Feature dependence plots for the geometric variables. ( a ) CatBoost dependence plot for X1, ( b ) CatBoost dependence plot for X2, ( c ) CatBoost dependence plot for X3, ( d ) CatBoost dependence plot for X5. 4. Discussion The current paper presents a novel technique for the optimum dimensioning of retaining walls. A data-driven approach is presented using four different ensemble learning techniques. Predictive machine learning models have been generated using a large dataset obtained through optimization. The thickness of the retaining wall stem at the bottom has been used as the decisive parameter that determines the overall size and cost of the structure. The database necessary to develop the predictive models has been generated using the HS optimization technique. Using this technique, a large database with over seventy thousand data samples was generated where each data sample consists of an optimum combination of eleven design variables and the total construction cost associated with them. The prediction accuracy of the different models has been presented using root mean square error (RMSE), mean absolute error (MAE), coefficient of determination (R 2 ), and Pearson correlation as the metrics of model performance. The highest prediction accuracy could be achieved by the CatBoost models followed by LightGBM, Random Forest, and XGBoost. The focus of this analysis was the optimization of the geometric dimensions of a retaining wall. The overall wall size and shape were described using six key geometric dimensions. Previous studies in the area of optimal structural dimensioning mostly attempted to minimize structural cost or weight for a single load case [ 8 , 9 ]. More recent studies in the area attempted to develop general-purpose predictive models based on a dataset of structural configurations with known structural behavior [ 21 , 22 ]. However, the availability of experimental or numerical data describing the structural behavior is a major limiting factor in the training of robust predictive models since the size of the database used in the training of these predictive models is a decisive factor that effects to what extent these models could be used reliably. Furthermore, the range of design variables included in the dataset determines the accuracy of the predictions on new data samples. The current study differentiates itself from the previous ones by generating comprehensive predictive models that incorporate a large number of samples and design variables. Both the size of the dataset and the ranges of the design variables were selected so that these ranges would include most load cases with practical relevance. As a result, a dataset of 71,660 data samples was generated using the harmony search optimization algorithm, which is significantly larger than the datasets previously used in this field. The current paper demonstrates the possibility of generating significantly larger datasets using optimization techniques. This novel approach has the potential to overcome the data availability limitations associated with training machine learning models for structural dimensioning. Using this approach, the applicability of machine learning algorithms to the field of engineering design can be greatly enhanced. From the SHAP summary plot, it could be observed that all geometric variables, except for the length of the heel (X1), have an increasing effect on the wall stem thickness at the bottom (X4). On the other hand, variables such as concrete unit cost, soil friction angle, and soil bearing capacity have a decreasing effect on X4 as their values increase. Furthermore, increasing the magnitude of the soil density ( γ ) was observed to have an increasing effect on X4. The thickness (X5) of the wall foundation was found to have the greatest impact on X4, whereas X3 was the variable with the least impact. The low impact of X3 on the model output can be attributed to the concentration of the X3 values around a single value in the entire database. 5. Conclusions The availability of large datasets is crucial for the development of accurate predictive models in machine learning and particularly in structural dimensioning. The current paper shows the generation of a database consisting of 71,660 unique optimal combinations of six different geometric variables and five parameters that describe the material properties and external loads. The harmony search algorithm has been utilized to obtain these optimal configurations. The major outcomes of this paper can be summarized as follows: Among the four ensemble learning models developed in this paper, the highest overall prediction accuracy could be achieved by the CatBoost model, with a maximum coefficient of determination score of 0.999 for the prediction of the optimum stem height and an average R 2 score of 0.927, while the XGBoost models demonstrated, on average, the lowest prediction accuracy. In terms of computational speed, the LightGBM models demonstrated the best performance, with an average duration of 6.17 s for the training and testing, whereas the CatBoost models were an order of magnitude slower than the LightGBM models. The results of the SHAP analysis showed that the thickness of the retaining wall foundation (X5), the unit cost of concrete (C c ), and the stem height of the wall have the greatest impact on the optimal design. The foundation thickness and concrete unit cost were found to be highly dependent on each other and a linear proportionality could be observed between the foundation thickness and the impact of this parameter on the optimal design configuration. Further research in this area can be carried out by setting different material properties such as the compressive strength of concrete or the yield strength of steel as the optimization objective. Furthermore, the arrangement of the steel reinforcement can be included in future studies as a design variable or optimization objective. One of the limitations of the current study is that a certain range of unit prices is assumed during the generation of the dataset which represents the quality of concrete. However, fluctuations in concrete unit prices have not been considered. Furthermore, it should be noted that the developed ensemble learning models are only applicable within variable ranges included in the training dataset. For variable values outside these ranges, detailed structural analysis and optimization techniques should be applied on a case-by-case basis. Author Contributions Methodology, G.B.; formal analysis (coding), C.C.; writing—original draft preparation, C.C. and G.B.; writing—review and editing, S.K. and Z.W.G.; visualization, C.C.; supervision, G.B., S.K. and Z.W.G.; funding acquisition, Z.W.G. All authors have read and agreed to the published version of the manuscript. Funding This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2020R1A2C1A01011131). Institutional Review Board Statement Not applicable. Informed Consent Statement Not applicable. Data Availability Statement The data presented in this study are available on request from the corresponding author. Conflicts of Interest The authors declare no conflict of interest. Appendix A Table A1. Metrics of Model Accuracy. Table A1. Metrics of Model Accuracy. Root mean square error (RMSE): RMSE = ∑ i = 1 n ( y i − y ~ i ) 2 n Coefficient of determination (R 2 ): R 2 = ( n ∑ i = 1 n y i y ~ i − ∑ i = 1 n y i ∑ i = 1 n y ~ i n ∑ i = 1 n y i 2 − ( ∑ i = 1 n y i ) 2 n ∑ i = 1 n y ~ i 2 − ( y ~ i ) 2 ) 2 Mean absolute error (MAE): MAE = ∑ i = 1 n | y i − y ~ i | n Pearson correlation coefficient: r xy = n ∑ i = 1 n x i y i − ∑ i = 1 n x i ∑ i = 1 n y i n ∑ i = 1 n x i 2 − ( ∑ i = 1 n x i ) 2 n ∑ i = 1 n y i 2 − ( ∑ i = 1 n y i ) 2 References Gomes, H.M. Truss optimization with dynamic constraints using a particle swarm algorithm. Expert Syst. Appl. 2011 , 38 , 957–968. [ Google Scholar ] [ CrossRef ] Dede, T. 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( a ) X1, ( b ) X2, ( c ) X3, ( d ) X4, ( e ) X5, ( f ) H. Figure 4. Comparison of the predicted and optimized dimensions using Random Forest. ( a ) X1, ( b ) X2, ( c ) X3, ( d ) X4, ( e ) X5, ( f ) H. Figure 6. Comparison of the predicted and optimized dimensions using CatBoost. ( a ) X1, ( b ) X2, ( c ) X3, ( d ) X4, ( e ) X5, ( f ) H. Figure 7. Taylor diagrams for the design variables. Figure 8. SHAP summary plot for X4. Figure 9. Feature dependence plots for the geometric variables. ( a ) CatBoost dependence plot for X1, ( b ) CatBoost dependence plot for X2, ( c ) CatBoost dependence plot for X3, ( d ) CatBoost dependence plot for X5. Table 1. Prediction accuracy of the machine learning models. Algorithm Variable R 2 MAE RMSE Duration [s] XGBoost X1 0.977 0.0697 0.2988 16.49 X2 0.958 0.0573 0.1319 19.12 X3 0.562 0.0092 0.0759 16.89 X4 0.967 0.0197 0.0708 17.88 X5 0.988 0.0075 0.0192 17.62 H 0.998 0.0907 0.1351 14.98 Random Forest X1 0.997 0.0279 0.1091 65.02 X2 0.958 0.0378 0.1220 62.47 X3 0.559 0.0083 0.0762 94.74 X4 0.960 0.0162 0.0776 66.19 X5 0.989 0.0052 0.0188 61.61 H 0.997 0.0702 0.1525 51.24 LightGBM X1 0.998 0.0463 0.0989 5.86 X2 0.947 0.0719 0.1383 5.68 X3 0.566 0.0100 0.0756 6.27 X4 0.966 0.0208 0.0725 5.59 X5 0.989 0.0075 0.0186 7.36 H 0.997 0.1051 0.1517 6.28 CatBoost X1 0.998 0.0281 0.0860 85.31 X2 0.960 0.0505 0.1189 73.05 X3 0.642 0.0093 0.0687 74.85 X4 0.971 0.0167 0.0660 85.76 X5 0.991 0.0056 0.0170 90.40 H 0.999 0.0524 0.0890 75.43 Table 2. Average predictive model accuracy and performance. Algorithm R 2 MAE RMSE Duration [s] XGBoost 0.9083 0.04235 0.12195 17.16 Random Forest 0.91 0.0276 0.0927 66.88 LightGBM 0.9105 0.0436 0.0926 6.17 CatBoost 0.92683 0.0271 0.07427 80.80 Bekdaş, Gebrail, Celal Cakiroglu, Sanghun Kim, and Zong Woo Geem. 2022. "Optimal Dimensioning of Retaining Walls Using Explainable Ensemble Learning Algorithms" Materials15, no. 14: 4993. https://doi.org/10.3390/ma15144993 MDPI and ACS Style Bekdaş, G.; Cakiroglu, C.; Kim, S.; Geem, Z.W. Optimal Dimensioning of Retaining Walls Using Explainable Ensemble Learning Algorithms. Materials 2022, 15, 4993. https://doi.org/10.3390/ma15144993 AMA Style Bekdaş G, Cakiroglu C, Kim S, Geem ZW. Optimal Dimensioning of Retaining Walls Using Explainable Ensemble Learning Algorithms. Materials. 2022; 15(14):4993. https://doi.org/10.3390/ma15144993 Chicago/Turabian Style Bekdaş, Gebrail, Celal Cakiroglu, Sanghun Kim, and Zong Woo Geem. 2022. "Optimal Dimensioning of Retaining Walls Using Explainable Ensemble Learning Algorithms" Materials15, no. 14: 4993. https://doi.org/10.3390/ma15144993
https://www.mdpi.com/1996-1944/15/14/4993/htm
-Continued. | Download Table Download Table | -Continued. from publication: Evolution of the mating season in the pitvipers of North America | In the majority of temperate zone snakes, the mating season is temporally dissociated from the time of fertilization. Similarly, in males, the mating season is often temporally dissociated from spermatogenesis. In temperate zone pitvipers of North America, estrus, the time... | Seasons, Estrus and Crotalus | ResearchGate, the professional network for scientists. TABLE 3 -Continued. Source publication Evolution of the mating season in the pitvipers of North America Full-text available In the majority of temperate zone snakes, the mating season is temporally dissociated from the time of fertilization. Similarly, in males, the mating season is often temporally dissociated from spermatogenesis. In temperate zone pitvipers of North America, estrus, the time when females signal that they are receptive to males, occur's at some time d... Rena De Paula Orofino Ligia Pizzatto Citations ... Introduction rent periods in congeneric species (Aldridge and Duvall, 2002; Pizzatto and Marques, 2006;Barros et al., 2012). Temperature and rainfall are the main abiotic factors influencing the reproductive cycles in snakes and, therefore, responsible for modulating the seasonality of cycles (Aldridge and Duvall, 2002;Lutterschmidt and Mason, 2009). ... (Aldridge and Duvall, 2002; (Aldridge and Duvall 2002) 68] Full-text available Mar 2022 Diversity Rubén Alonso Carbajal Márquez José Jesús Sigala-Rodríguez Jorge Arturo Hidalgo-García Juan José Ayala Rodríguez José Rogelio Cedeño-Vázquez The Tehuantepec Isthmus rattlesnake (Crotalus ehecatl) is a poorly known species endemic to Mexico. We describe its diet, morphological variation, life history traits and activity patterns based on data from field encounters, museum specimens, and published data. Its diet consists almost exclusively of mammals, with no detected ontogenetic shift or sexual differences in prey type, and with feeding happening mainly in the rainy season. As the first detailed study on the feeding ecology of C. ehecatl, it adds six new prey species and suggests a homogeneous diet among age classes and sexes, but not among seasons. Crotalus ehecatl does not present sexual dimorphism in snout-vent length, head length or total length, but males have significantly longer tails than females, possess fewer ventral scales, more subcaudal and anterior intersupraocular scales. Crotalus ehecatl showed a unimodal activity pattern with peak activity in the summer, with crepuscular and nocturnal activity during the warmer months, and diurnal activity during the cooler months. The timing of C. ehecatl reproductive events, is similar to other rattlesnakes from temperate and tropical zones. Additional studies on this and related species would help to understand how the ecology of Neotropical rattlesnakes differs from rattlesnakes of more temperate zones. ... larger than those of females, and moving up to 6.24 m/d (88.9%) more than females. We expected these differences, as males of C. ruber elsewhere [49] and those of other rattlesnake species (e.g., [89][90][91][92] [93] ; but see [94]) exhibit greater levels of activity than females. Moreover, the activity range size increased with increasing SVL for male snakes, but not for female snakes. ... Human–Wildlife Conflict at a Suburban–Wildlands Interface: Effects of Short- and Long-Distance Translocations on Red Diamond Rattlesnake (Crotalus ruber) Activity and Survival Article Full-text available Feb 2022 Diversity Aaron G. Corbit William K. Hayes The mitigation of human–rattlesnake conflicts often involves euthanizing or translocating the offending rattlesnake. Although translocation is generally considered more humane, especially by the general public, it may negatively impact the translocated individual and may not be effective if that individual returns to areas where the probability of human conflict is high. We used radiotelemetry to experimentally study the effects of short- (SDT) and long-distance translocation (LDT; beyond the typical home range or activity range) on adult Red Diamond Rattlesnakes (Crotalus ruber) near a residential development in Southern California. Though the results were mixed, some analyses suggested that higher numbers of SDTs were associated with larger activity areas and increased movement. For snakes undergoing LDT, the activity areas and mean daily movement distances were 1.8–4.6 times larger than those of non-LDT snakes in the year of translocation, but were similar in the following year. Cox regression models revealed that, for both LDT and non-LDT snakes, every 1 m increase in the distance moved resulted in a 1.2% decreased risk of moving back into a human-modified area and a 1.6% decreased risk of returning to the original site of conflict. We failed to detect an effect of either LDT or SDT on body mass change or survival. Our findings suggest that LDT of nuisance snakes may be a viable option for at least some rattlesnake populations or species, especially those in which individuals do not require communal overwintering sites. ... The diameter of the SSK showed a peak in winter and spring, but there was no total regression during the other seasons. Similar feature was also observed in other species of snakes (Fox 1977 , Aldridge & Duvall 2002 , Aldridge et al. 2009). The T. dorsatus from Brazilian south region also had an increased secretory activity of SSK in spring (Loebens et al. 2020). ... Seasonal variations of male reproductive parameters of Tomodon dorsatus from Southeastern Brazil Article Full-text available Jun 2021 PESQUISA VET BRASIL Luciane Lily Abud Bruno Cesar Schimming The morphology of the male reproductive tract of Tomodon dorsatus was described in the austral seasons of the year considering macroscopic and microscopic variables. For this purpose, 56 specimens from the herpetological collection of the “Instituto Butantan” were used. Fragments of the testes, kidneys and ductus deferens were collected and submitted to histological routine. The peak of the testicular volume was observed in the summer and the epithelium of the seminiferous tubules had higher height in the summer (p=0.001). The testes were active throughout the year, however, the spermiogenesis peaked in the summer. There were spermatozoa in the lumen of the ductus deferens in all seasons of the year. Renal length was higher in autumn (p=0.027), and renal width did not show a significant increase (p=0.237). The diameter and epithelial height of the sexual segment of the kidney (SSK) showed hypertrophy in winter and spring, coinciding with the mating period. Based on findings of this study, we can suggest that, at the population level, the reproductive cycle of T. dorsatus can be considered seasonal semi-synchronous, due to the peak of spermiogenic activity in the hot season, and discontinuous at the individual level. ... Females were considered mature if they had vitellogenic follicles; oviductal eggs; enlarged, opaque and folded uterus; sperm in the oviduct after histological analysis; or UMC . Because females are more receptive to copulate during vitellogenesis (Aldridge and Duvall, 2002; Bassi et al., 2019), we estimated the mating season by the presence of vitellogenic females with sperm in the oviduct or with a copulatory plug in the pouch. ... ... Our finding of a previtellogenic female with copulatory plug in March and December suggests that some mating activity occurs outside the major autumn-winter mating season. However, since mating in crotalines is commonly synchronous with vitellogenesis (Aldridge and Duvall, 2002; Almeida-Santos & Salomão, 2002), the copulatory plug in previtellogenic females may be a remnant of previous copulation. Finally, the gravid female collected in March suggests the occurrence of sperm storage. ... Reproduction in the bushmaster (Lachesis muta): Uterine muscular coiling and female sperm storage Article Dec 2020 ACTA ZOOL-STOCKHOLM Eletra de Souza Selma Maria Almeida-Santos Prolonged sperm storage in the female reproductive tract is a widespread strategy among vertebrates. In reptiles, especially lizards and snakes, females have specialized structures to store sperm in their oviduct, which occur in the posterior infundibulum and the nonglandular uterus. Many viperids exhibit uterine muscular coiling (UMC) in the nonglandular uterus, and this modification has been proposed as an ancestral trait in this taxon to store sperm. However, UMC and oviductal sperm storage have not been reported in Lachesis. Here, we studied the reproductive tract of L. muta females using histological techniques and describe, for the first time, the occurrence of oviductal sperm storage and UMC in nonglandular uterus of this species. We also describe an increase in secretory activity in the oviduct throughout the reproductive cycle. Our results support the hypothesis that UMC is an ancestral character in Viperidae and suggest that female L. muta must store sperm in the oviduct to fertilize the oocytes. We also propose new hypotheses for reproductive strategies of L. muta in nature. ... Sex-based differences for home ranges and movement patterns were anticipated (Smith et al. 2009, Sutton et al. 2017, although the differences between males and female were less pronounced at the urban forest. Seasonal changes in activity in the spring and late summer were also expected, as it has been previously noted that southeastern Copperheads mate twice a year (Aldridge and Duvall 2002, Ernst andErnst 2011). Urban subjects may have smaller home ranges and core areas because of denser food availability (Wasko and Sasa 2012), predator release (Steen et al. 2014), human disturbance (Beale et al. 2016), or a combination of circumstances. ... Cozy in the City: The Morphology and Spatial Ecology of Copperheads in an Urban Forest Article Full-text available Oct 2020 Malle Carrasco-Harris Judith A Cole Steve Reichling Anthropogenic environments alter behaviors in a wide variety of taxa. We examined the morphology and spatial ecology of Agkistrodon contortrix Linnaeus (Eastern Copperhead) within an urban forest and a rural forest in Tennessee. We captured snakes for morphological data and radio tracked 36 urban and 8 rural subjects to collect spatial data. We estimated home range size, core area, and movement parameters (total distance moved; daily, sampling, and monthly movement) using relocation data. Copperheads in the urban forest were smaller but did not differ in body condition compared to rural conspecifics. We found urban Copperheads had reduced home ranges, core areas, and movement parameters compared to rural subjects. Our study suggests urban snakes alter spatial behavior by decreasing overall movement. https://eaglehill.us/URNAonline2/access-pages/035-Carrasco-Harris-accesspage.shtml ... The timing of testicular recrudescence (i.e., early spermatogenesis) appears largely conserved in crotalines, occurring in spring in virtually all species studied (Tsai and Tu, 2000; Aldridge and Duvall, 2002; Salomão and Almeida-Santos, 2002;Barros et al., 2014aBarros et al., , 2014bSilva et al., 2019b). However, males show one of two seasonal patterns of spermiogenesis/spermiation (i.e., peak of spermatogenesis). ... ... Winter-spring mating would depend on females being attractive and receptive to males. In these seasons, many female B. jararacussu are vitellogenic and thus potentially attractive to males (Aldridge and Duvall, 2002; Mathies et al., 2013). So far, there are only three records of mating in B. jararacussu, and all of them occurred in autumn (Almeida-Santos and Silva et al., 2013;this study). ... Reproduction in the pitviper Bothrops jararacussu: large females increase their reproductive output while small males increase their potential to mate Article Jun 2020 ZOOLOGY Karina M.P. Silva Henrique B. Braz Karina N. Kasperoviczus Otavio A.V. Marques Selma M. Almeida-Santos Reproductive traits vary widely within and among snake species, and are influenced by a range of factors. However, additional studies are needed on several species, especially on tropical snake faunas, to fully understand the patterns of reproductive variation in snakes. Here, we characterized the reproductive biology of B. jararacussu from southeastern and southern Brazil. We combined macroscopic and microscopic examinations of the reproductive system of museum specimens with observations of free-ranging snakes to characterize size at sexual maturity, sexual size dimorphism, reproductive output, and male and female reproductive cycles. We compared our data with published literature and discuss the factors that may play a role in shaping the reproductive patterns in the species and the genus. Bothrops jararacussu shares several characteristics with its congeners such as autumn mating season, obligatory sperm storage in the female reproductive tract, seasonal timing of parturition (summer-autumn), female-biased SSD, maturity at larger body sizes in females, and a positive relationship between body size and litter size. These characteristics seem phylogenetically conserved in Bothrops. On the other hand, B. jararacussu exhibits some unique characteristics such as a high degree of SSD (one of the highest values recorded in snakes), a large female body size, and a large litter and offspring size, which are among the largest recorded in the genus. Moreover, larger females reproduce more frequently than smaller conspecifics. These characteristics may be collectively interpreted as the result of a strong selection for increased fecundity. Other peculiarities of the species include an asynchrony between spermiogenesis (summer-autumn) and the peak of SSK hypertrophy (autumn to spring) and a prolonged production of SSK granules. Because SSK hypertrophy and mating are androgen-dependent in snakes, the prolonged SSK hypertrophy suggests that male B. jararacussu may prolong their potential to mate (compared with its congeners), which may increase their reproductive success. Our results and previous literature collectively suggest that, in Bothrops, the evolution of SSD is driven by fecundity selection, variation in reproductive output is influenced by variation in female body size, and the timing of spermiogenesis is influenced by other factors in addition to temperature. We also suggest that male Bothrops have undergone multiple evolutionary shifts in the timing of spermiogenesis. ... In its subtropical range in Central Florida, S. miliarus populations display a highly seasonal reproductive pattern that is typical of more temperate populations, with a few notable exceptions: (1) The mating season begins in the late summer, but continues until February (May et al., 1996;Rowe et al., 2002: Lind et al., 2019 and (2) both males and females are surface active and forage throughout winter, after which, vitellogenic follicles large enough to be identified by palpation are evident from March until ovulation in late May or early June (i.e. consistent with a type I vitellogenic pattern; Aldridge, 1979; Aldridge and Duvall, 2002) . This population differs from other snake populations in which female steroids have been examined (e.g. ... ... Diagnosis of vitellogenesis by palpation is limited and may fail to diagnose initial vitellogenin production or small amounts of yolk deposition. However it is clear that the elevation of E2 in the fall is not associated with the recruitment of large secondary follicles as seen in many other North American pitvipers (Aldridge and Duvall, 2002) . Also of note, while E2 is elevated in individuals during spring vitellogenesis, no mating activity is observed in the spring months (Rowe et al., 2002;Lind et al., 2018). ... The relationship between steroid hormones and seasonal reproductive events in free-living female Pygmy Rattlesnakes, Sistrurus miliarius Article Jan 2020 GEN COMP ENDOCR Craig M. Lind Ignacio T. Moore Ben J. Vernasco La'Toya V. Latney Terence M. Farrell Steroid hormones regulate reproductive investment and play a critical role in coordinating reproductive responses to both short and long-term environmental change. Laboratory studies typically examine the mechanistic relationships among steroids and reproductive processes under controlled conditions and may fail to identify any seasonal patterns in regulatory mechanisms exhibited by free-living organisms. In snakes, field studies describing the seasonal relationships among steroids and male reproduction are prevalent. However, comparatively less work has been conducted on free-living female snakes. To bridge this gap in knowledge, we described the seasonal patterns of estradiol (E2), corticosterone (cort), and plasma constituents (total protein, albumin, phosphorus, and glucose) in relation to the seasonal events of the reproductive cycle in free-living female pygmy rattlesnakes (Sistrurus miliarius). We predicted to observe elevated E2 and plasma constituents during the spring vitellogenenic season, and that E2 would also be elevated during the fall mating season. Additionally, we hypothesized that cort acts to mobilize resources to meet the energetic challenges experienced during reproduction. We, therefore, predicted that elevated cort would be associated with the vitellogenic season and summer pregnancy, and that cort would be positively associated with elevated E2 and plasma constituents. In S. miliarius, plasma estradiol was significantly elevated during both the fall mating and spring vitellogenic seasons. Elevated E2 was associated with significantly higher plasma total protein, albumin, and phosphorous in both seasons, but unrelated to plasma glucose. Corticosterone was not elevated in individuals with elevated E2. Additionally, cort was not related to plasma total protein, albumin, or phosphorus, but was positively related to plasma glucose. Corticosterone was elevated during late pregnancy compared to early pregnancy and postpartum, and also elevated in pregnant compared to non-reproductive females sampled in the field. Our results indicate that the mechanistic links between steroids and reproductive processes may be seasonally uncoupled and highlight the need for the continued study of the hormonal coordination of reproduction in free-living vertebrates with diverse life histories. ... Regarding the female body size at which sexual maturity is acquired, our hypothesis is not met. Reproduction represents a risk for female survival regardless of their offspring productivity (Aldridge and Duvall 2002) ; hence, natural selection forces females to attain a minimum body length to reproduce, which implies a minimum clutch size that overcomes the risks of their first reproductive period (Seigel and Ford 1987). For this reason, we expected females from both populations to become sexually active at the same body length. ... Reproduction ecology of the recently invasive snake Hemorrhois hippocrepis on the island of Ibiza Knowing the causes of biological invasion success can be relevant to combat future invasive processes. The recent invasion of the horseshoe whip snake (Hemorrhois hippocrepis) on the island of Ibiza provides the opportunity to compare natural history traits between invasive and source populations, and to unravel what makes this snake a successful invader that is threatening the only endemic vertebrate of the island, Podarcis pityusensis. This study compares basic reproductive traits of mainland native and invasive populations of the snake. Our results revealed that invasive populations were characterized by female maturity at a smaller size, extended reproductive period, and much lower reproduction frequency compared to the native population. In contrast, some major reproductive traits –the abdominal fat body cycle, clutch size, hatchling body size and hatchling body condition, did not differ between the two populations. Some of these results must reflect the environmental differences in the recently invaded island with respect to the source area, and overall plasticity of reproductive traits. Plasticity is evolutionarily interesting, and may aid the successful growth of this species in their invasiveness of Mediterranean islands like Ibiza. The most significant finding is that this expression of phenotypic plasticity occurred rapidly in this invasive population, within a period of 14 years maximum. Our results on the reproduction ecology of the invasive population were not conclusive regarding the factors determining the invasiveness of the snake and pointed to alternative causes.
https://www.researchgate.net/figure/Continued_tbl2_238446667
Graham v. Inlow, 90-45 - Arkansas - Case Law - VLEX 888670698 0: [object Object]. 1: [object Object]. 2: [object Object]. 3: [object Object]. 4: [object Object]. 5: [object Object] Graham v. Inlow, 90-45 <table><tbody><tr><td> Court</td><td> Supreme Court of Arkansas</td></tr><tr><td> Writing for the Court</td><td> GLAZE</td></tr><tr><td> Citation</td><td> 302 Ark. 414,790 S.W.2d 428</td></tr><tr><td> Parties</td><td> Patricia GRAHAM, Appellant, v. Charles W. INLOW, Carol J. Inlow, and Freda Evelyn Inlow, Appellee.</td></tr><tr><td> Docket Number</td><td> No. 90-45,90-45</td></tr><tr><td> Decision Date</td><td> 04 June 1990</td></tr></tbody></table> Page 428 790 S.W.2d 428 302 Ark. 414 Patricia GRAHAM, Appellant, v. Charles W. INLOW, Carol J. Inlow, and Freda Evelyn Inlow, Appellee. No. 90-45. Supreme Court of Arkansas. June 4, 1990. Page 429 [302 Ark. 415] Howard L. Slinkard, Rogers, for appellant. Charles L. Harwell, Springdale, for appellee. GLAZE, Justice. This second appeal stems from our earlier reversal and remand of this partition suit case wherein we held valid a deed from Robert Inlow to his second wife, Freda, and [302 Ark. 416] his three children. See Graham v. Inlow,296 Ark. 165,753 S.W.2d 277(1988). Robert had two children, Charles and Carol, by his wife Freda, and he had another child, Patricia Graham, by his first wife. In remanding this case, the trial court was placed in the position of reconsidering Graham's request for partitioning the parties' one-fourth respective interest in the 287 acre farm. The chancellor found the property could not be partitioned in kind and ordered the sale of the farm.The chancellor Page 430 further held that Graham was entitled to certain rental income and timber sale proceeds after her commencement of the suit as well as attorney fees and costs in connection with prosecuting this partition action. He also awarded Freda the sum of $70,000 for improvements she made on the disputed property. Graham appeals and the Inlows cross appeal from the awards made by the chancellor. In the first point, the appellant argues that the chancellor erred in awarding reimbursement for improvements made on the property for two reasons: (1) Freda did not show that the improvements were made in good faith that she was the sole owner of the property as required by the Betterment Statute, Ark.Code Ann. § 18-60-213 (1987); (2) Freda failed to present any testimony to show the improvement's enhanced value to the land. Because we agree with appellant's second argument on this point, we reverse and remand. The Betterment Statute, Ark.Code Ann. § 18-60-213(a), provides as follows: If any person believing himself to be the owner, either in law or equity, under color of title has peaceably improved, or shall peaceably improve, any land which upon judicial investigation shall be decided to belong to another, the value of the improvement made as stated and the amount of all taxes which have been paid on the land by the person, and those under whom he claims, shall be paid by the successful party to the occupant, or the person under whom, or from whom, he entered and holds, before the court rendering judgment in the proceedings shall cause possession to be delivered to the successful party. In awarding Freda $70,000 for reimbursement for improvements made by her, the chancellor held that the Betterment Statute [302 Ark. 417] does not apply to cotenants but that the underlying principles and theories are analogous to the relief under the common law. We have held that the Betterment Statute applies to tenants in common. Wallis v. McGuire,234 Ark. 491,352 S.W.2d 940(1962). However, the chancellor was correct in that the statute does not apply to tenants in common in this type of action. Section 18-60-213 is found in the Code under the subchapter for ejectment and trespass, and applies to cotenants who are involved in such actions. In the present case, however, we are involved with a partition suit governed in the Code by the subchapter for partition and sale of land, specifically Ark.Code Ann. § 18-60-401 (1987). It is well settled that a tenant in common has the right to make improvements on the land without the consent of his cotenants; and, although he has no lien on the land for the value of his improvements, he will be indemnified for them, in a proceeding in equity to partition the land between himself and cotenants, either by having the part upon which the improvements are located allotted to him or by having compensation for them, if thrown into the common mass. Bowers v. Rightsell,173 Ark. 788,294 S.W. 21(1927); see also Welch v. Burton,221 Ark. 173,252 S.W.2d 411(1952); Kelley v. Acker,216 Ark. 867,228 S.W.2d 49(1950). The improvements must be made in good faith and have benefit to the premises. Thompson, Real Property, § 5295 (1957). See generally 59A... 13 practice notes Denton v. Lazenby, 68944 United States United States State Supreme Court of Kansas August 17, 1994 ...which the nonimproving cotenant did not desire or which do not comparably increase the value of the property. See Graham v. Inlow, 302 Ark. 414, 790 S.W.2d 428 (1990); In re Marriage of Berger, 140 Ariz. 156, 680 P.2d 1217 (1983); Capogreco v. Capogreco, 61 Ill.App.3d 512, 18 Ill.Dec. 815, ...... Trice v. Trice (In re Slaughter), CV-19-786 United States Supreme Court of Arkansas November 4, 2021 ...is a question of fact, and we will not reverse that determination absent a showing that it was clearly erroneous. Graham v. Inlow , 302 Ark. 414, 419, 790 S.W.2d 428, 431 (1990).In the present case, on the issue of notice, the circuit court ruled:The Petitioners and Third-Party Defendants w...... Trice v. Trice (In re Slaughter), CV-19-786 United States Supreme Court of Arkansas November 4, 2021 ...is a question of fact, and we will not reverse that determination 7 absent a showing that it was clearly erroneous. Graham v. Inlow, 302 Ark. 414, 419, 790 S.W.2d 428, 431 (1990). In the present case, on the issue of notice, the circuit court ruled: The Petitioners and Third-Party Defendant...... Mitchell v. Hammons, CA United States Court of Appeals of Arkansas June 20, 1990 ...adverse possession we begin with the familiar rule that the possession of one tenant in common is the possession of all. Graham v. Inlow, 302 Ark. 414, 790 S.W.2d 428 (1990); Ueltzen v. Roe, 242 Ark. 17, 411 S.W.2d 894 (1967); Franklin v. Hempstead County Hunting Club, 216 Ark. 927, 228 S.W...... 13 cases Denton v. Lazenby, 68944 United States United States State Supreme Court of Kansas August 17, 1994 ...which the nonimproving cotenant did not desire or which do not comparably increase the value of the property. See Graham v. Inlow, 302 Ark. 414, 790 S.W.2d 428 (1990); In re Marriage of Berger, 140 Ariz. 156, 680 P.2d 1217 (1983); Capogreco v. Capogreco, 61 Ill.App.3d 512, 18 Ill.Dec. 815, ...... Trice v. Trice (In re Slaughter), CV-19-786 United States Supreme Court of Arkansas November 4, 2021 ...is a question of fact, and we will not reverse that determination absent a showing that it was clearly erroneous. Graham v. Inlow , 302 Ark. 414, 419, 790 S.W.2d 428, 431 (1990).In the present case, on the issue of notice, the circuit court ruled:The Petitioners and Third-Party Defendants w...... Trice v. Trice (In re Slaughter), CV-19-786 United States Supreme Court of Arkansas November 4, 2021 ...is a question of fact, and we will not reverse that determination 7 absent a showing that it was clearly erroneous. Graham v. Inlow, 302 Ark. 414, 419, 790 S.W.2d 428, 431 (1990). In the present case, on the issue of notice, the circuit court ruled: The Petitioners and Third-Party Defendant...... Mitchell v. Hammons, CA United States Court of Appeals of Arkansas June 20, 1990 ...adverse possession we begin with the familiar rule that the possession of one tenant in common is the possession of all. Graham v. Inlow, 302 Ark. 414, 790 S.W.2d 428 (1990); Ueltzen v. Roe, 242 Ark. 17, 411 S.W.2d 894 (1967); Franklin v. Hempstead County Hunting Club, 216 Ark. 927, 228 S.W......
https://case-law.vlex.com/vid/graham-v-inlow-no-888670698
Hisense Electric LCDC0036 Part15 Subpart B-LED LCD TV User Manual W9HLCDC0036 3 User manual instruction guide for Part15 Subpart B-LED LCD TV LCDC0036 Hisense Electric Co., Ltd.. Setup instructions, pairing guide, and how to reset. Hisense Electric LCDC0036 Part15 Subpart B-LED LCD TV User Manual W9HLCDC0036 3 Hisense Electric Co., Ltd. Part15 Subpart B-LED LCD TV W9HLCDC0036 3 Contents 1. W9HLCDC0036_User Manual 1 2. W9HLCDC0036_User Manual 2 3. W9HLCDC0036_User Manual 3 W9HLCDC0036_User Manual 3 English ES-G160207 Table of Contents Connecting Devices to Your TV ..............................................................................3 Connecting an antenna, cable or satellite box ..................................................................................3 Connecting an Audio Visual (AV) device with a composite cable .....................................................3 Connecting an AV device with an HDMI cable ..................................................................................4 Connecting headphone .....................................................................................................................4 Connecting a USB device to the USB port ........................................................................................4 Connecting speakers or other audio receivers ..................................................................................5 Connecting to the Internet through a Wireless (WiFi) Device ............................................................5 Guided Setup ............................................................................................................6 Starting Guided Setup........................................................................................................................6 Connected TV Home Screen ...........................................................................................................11 Non-connected TV Home screen.....................................................................................................12 Benefits of connecting .......................................................................................... 13 Connecting brings out your TV’s full potential! ................................................................................13 What is streaming? ...........................................................................................................................13 But what if I didn’t connect my TV? ..................................................................................................14 Setting upAntenna TV ...........................................................................................15 Why do I have to set up the TV tuner? .............................................................................................15 How do I set up the TV tuner? ..........................................................................................................15 Using your TV .........................................................................................................18 TV status light ...................................................................................................................................18 TV panel buttons ..............................................................................................................................18 Remote control ................................................................................................................................. 19 Getting around .................................................................................................................................19 Watching broadcast TV channels .................................................................................................... 21 Switching TV inputs ..........................................................................................................................22 Playing content from USB storage devices .....................................................................................23 Playing content from local network media servers ..........................................................................23 Adjusting TV settings ............................................................................................24 Settings menu ..................................................................................................................................24 Options menu ...................................................................................................................................24 Advanced picture settings ............................................................................................................... 26 Table of Contents Searching for movies and shows .........................................................................27 How do I search? .............................................................................................................................27 I found a show, now what? ...............................................................................................................27 Using the Roku Channel Store .............................................................................28 Customizing your TV .............................................................................................29 Rearrange tiles ................................................................................................................................. 29 Edit broadcast TV channel lineup .................................................................................................... 29 Rename inputs .................................................................................................................................30 Remove unwanted tiles .................................................................................................................... 30 Change themes ................................................................................................................................30 Change sound effects volume .........................................................................................................31 Configure power settings ................................................................................................................. 31 Configure parental controls..............................................................................................................32 More settings ..........................................................................................................36 Changing network settings ..............................................................................................................36 Changing caption settings ............................................................................................................... 36 Changing time settings ....................................................................................................................37 Scanning for broadcast TV channels again .....................................................................................37 Using the TV in a home theater ........................................................................................................38 Restarting the TV ..............................................................................................................................40 Resetting the TV ............................................................................................................................... 40 Getting system updates ................................................................................................................... 40 Other devices .........................................................................................................42 Getting and using the Roku mobile app ..........................................................................................42 Quick Problem-Solving Tips .................................................................................43 Connecting Devices toYour TV You have several options for connecting your TV to different devices. The method in which you connect will be based upon the type of cables you have and the available outputs on your device. Connecting an antenna, cable or satellite box To connect an antenna,cable set-top box or satellite receiver: 1. Connect one end of a coaxial cable (not included) to the RF OUTport on the antenna, cable or satellite box. If you are using an antenna with twin-lead cable, you may need a 300-75 Ohm adapter (not provided) to connect it to the back of your TV. Likewise, if you are using several antennas, you may need a combiner (not provided). 2.Connect the other end of the cable to the ANT/CABLEport on the side of the back panel. 3.Using your remote, press the [ ] button and select TV as the input source. Connecting anAudio Visual (AV) device with a composite cable To connect anAV device with a composite video cable (not provided): 1. Use the audio and video cables to connect the composite video/audio ports of the externalAV device to the AV IN ports of the TV. (Video = yellow,Audio Left = white, andAudio Right = red). 2.Plug the connected devices into theAV connectors on the TV before switching it on. 3.Using your remote, press the [ ] button and select AV as the input source. or AN TOUT Cable Set top box RF Out EXTERNA LDEVICE TV PORT ANT/CABLE (not included) (not included) AV OUT Vi deo White (L)White (L) Yellow (Video)Yellow or Green (Video) Red (R)Red (R) Audio Cable TV PORTS VIDEO LR AV IN EXTERNA LDEVICES DVD Player/Recorder Vi deo Camera Set-top box Satellite Receiver Satellite antenna cable VCR Connecting anAV device with an HDMI cable This type of connection supports digital connections between HDMI-enabledAV devices such as a Personal Video Recorder (PVR), DVD, Blu-Ray,AV receiver and digital devices. In addition, some devices (such as a PVR or DVD player) require an HDMI signal to be set to Output in the settings of the device. For instructions, please refer to the User Manual for the device. To connect anAV device with an HDMI cable (not provided): 1.Use an HDMI cable to connect the HDMI output port of theAV device to the HDMIport on the TV. 2.Plug the connected devices into the HDMIport on the TV before switching it on. 3.Using your remote, press the [ ] button and select the corresponding HDMI input. NOTES • Because the HDMI connector provides video and audio signals, it is not necessary to connect an audio cable. • We strongly recommend to use HDMI Cable with 2 cores as shown in the figure. Connecting headphone You can connect headphone (not provided) to the AUDIO OUT port on your TV. While the headphone is connected, the sound from the built-in speakers will be disabled. Connecting a USB device to the USB port 1. Connect the USB devices such as hard drives, USB sticks and digital camerasfor browsing photos, listening music and watching recorded movies into the USBport. 2. Select the Roku Media Playertile from the Home screen . NOTES • When connecting a hard disk or a USB hub, always connect the mainsadapter of the connected device to the power supply. • If a USB 1.1 or USB2.0 device requires more than 500mAor 5V, the USB device may not be supported. Exceeding the max supported current may result in damage or data loss. HDMI HDMI EXTERNA LDEVICES DVD Set-top Box TV PORT HDMI Cable AUDIO OUT TV PORT EXTERNA LDEVICE Headphone TV PORT EXTERNA LDEVICE USB DC 5V 0.5A(MAX) Connecting Devices toYour TV Connecting speakers or other audio receivers To connect speakers or other audio receivers with an audio cable (not provided): 1. Use an audio cable to connect the digital audio in port of the audio receiver device to the DIGITAL AUDIOOUT port of the TV.Another option is to use an RCAY-cable (1/8”-stereo mini to L/R phono) to connect analog sound system to the AUDIO OUT port of the TV. 2.Plug the connected devices into the main socket before switching on the TV. Connecting to the Internet through a Wireless (WiFi) Device This section shows how to establish a wireless Internet connection for your TV. Our built-in wireless LAN adapter supports the IEEE 802.11 b/g/n communication protocols and we recommend that you use an IEEE 802.11n router. When you play a video over an IEEEE 802.11 b/g connection, the video may not play smoothly. NOTES • You must use the SHARP built-in Wireless LANAdapter to use a wireless network because the TV does not support an external USB network adapter. • To use a wireless network, your TV must be connected to a wireless IPsharer. If the wireless IP sharer supports Dynamic Host Configuration Protocol (DHCP), your TV can use a DHCPor static IP address to connect to the wireless network. • Select a channel for the wireless IP sharer that is not currently being used. If the channel set for the wireless IPsharer is currently being used by another device nearby, this will result in interference and communication failure. • If you apply a security system other than the systems listed below, it will not work with the TV. • If Pure High-throughput (Greenfield) 802.11N mode is selected and the Encryption type is set to WEP, TKIP orTKIP-AES (WPS2 Mixed) for yourAccess Point (AP), then the SHARPTV will not support a connection in compliance with these Wi-Fi certification specifications. • If your access point (AP) supports Wi-Fi Protected Setup (WPS), you can connect to the network via Push Button Configuration (PBC) or PIN (Personal Identification Number). WPS will automatically configure the SSID. EXTERNA LDEVICES Powerless Bass Speaker Speaker Digital Sound Bar Audio Amplifier DIGI TAL AUDIO OUT AUDIO OUT TV PORTS Audio Cable White(L) Red(R) Audio Cable WirelessAdapter built-in the TV set LAN Cable Wireless Wi-Fi device or Wireless IP sharer The LAN Port on the Wall Connecting Devices toYour TV Guided Setup With the preliminaries out of the way, it’s time to turn on your TV.As the TV starts for the first time, it leads you through Guided Setup, which configures the TV before you start to use it. During Guided Setup, you’ll: • Answer a few questions • Provide network connection information • Get a software update • Link the TV to your Roku account • Connect devices such as a DVD player, game console, or cable box NOTE • Guided Setup only runs the first time you turn on your TV. If you need to run Guided Setup again, you’ll have to perform a factory reset, as explained in Factory reset everything on page 40. Starting Guided Setup To start Guided Setup, press the red [POWER]button on the remote control to turn on your TV. When you first turn on your TV, it will take a few seconds to get itself ready. You’ll notice the following things happening: The status light blinks every time the TV is busy doing something; in this case it’s powering up and getting ready for you. The Power-on screen appears and the status light blinks slowly for a few more seconds. ThePower-on screen displays a TV logo while the TV starts up. After a few seconds, the Guided Setup starts. If the TV prompts you for a language, press the [DOWN]on the remote control to highlight your preferred language. Setting up your TV With the first Guided Setup screen on your TV, follow these steps to set up your TV: 1.Press the [OK]or [RIGHT]buttons on the remote control to go to the next screen: 2.Press [OK]to select Set up for home use. Home mode is the right choice for enjoying your TV. NOTE • ‘Store’mode configures the TV for retail display and is not recommended for any other use. In store mode, some features of the TV are missing or limited.To switch from one mode to the other, you have to perform a factory reset as explained in Factory reset everything on page 40, and then repeat Guided Setup. After you select Set up for home use, the TV scans for the wireless networks within range and displays them in order, with the strongest signals first. In addition to your own wireless signal, the TV might pick up signals from your neighbors. 3.Press [UP]or [DOWN]to highlight the name of your wireless network, and then press [OK]to select it. NOTE • Some wireless networks, such as those often found in dorm rooms, hotels, and other public places, may require you to read and agree to terms, enter a code, or provide identifying information before letting you connect to the Internet. If the Roku TV detects that you are connecting to such a network, it prompts you through the connection process using your compatible smartphone or tablet to provide the needed information. Other options: Connect to the Internet later – If you’re unable to connect to the Internet, that’s OK.You can skip this step and use the TV to watch broadcasts, play games, and watch DVDs. If you want to connect later, it’s easy. We’ll show you how in Benefits of connecting on page 13 . NOTE • If you decide not to connect, Guided Setup skips ahead to setting up the devices that you’ve connected to your TV. See Non-connected TV Home screen on page 12to get started using your non-connected TV. Scan again / Scan again to see all networks – This option depends on the number of wireless networks within range: • Scan again appears if the list already shows all available wireless networks within range. If you don’t see your wireless network name in the list, you might need to adjust the location of your wireless router or the TV, turn on your router, or make other changes. When everything is ready, select Scan againto see if your network name now appears in the list. • Scan again to see all networks appears if theTV finds more than seven wireless networks, because the TV initially displays only the strongest seven networks. If you don’t see your wireless network name in the list, this option displays the complete list. If you still don’t see your network name, you might have your router configured to provide wireless service as a “private network.” NOTE • Highlighting either of these options displays an informational panel with the unique media access control (MAC) address of your Roku TV. You will need the MAC address if your wireless router is configured to use MAC address filtering. Private network – If your wireless network name is hidden, it won’t appear in the list. SelectPrivate network to display an on-screen keyboard, and use it to enter your network name. Unless you changed the factory-set network name, you can find the name (also called SSID) on a label on the router. Guided Setup 4.If your network is password-protected, an on-screen keyboard appears. Use the keyboard to enter the network password. 5. After you submit your network password, the TV displays progress messages as it connects to your wireless network, your local network, and the Internet. 6. Your TV needs to know the local time zone so that it can correctly displaytime informationabout the program you are currently watching. If the TV is unable to automatically determinethe local time zone, it prompts you to choose your time zone from a list. Use the [UP]and [DOWN]buttons to highlight your time zone, and then press [OK]. 7.As soon as the TV is able to connect to the Internet, it downloads and installs its first software update, and then restarts. TIP: Your TV automatically checks for updates periodically. These updates provide new features and improve your overall experience with the TV.After an update, you might notice that some options have moved, and that there are new options or features. After the TV restarts, it displays the Activationscreen: Guided Setup 8. Using a computer, tablet, or smartphone with an Internet connection, go to the web address displayed on the screen and enter the code that appears on your screen. You need a Rokuaccount to complete this step. Ifyou already have a Rokuaccount, you’ll be asked to log in. If you don’t, you’ll be asked to create one. You’ll have the option to create a Roku PIN code that can be used to authorize any purchases or payments. After you log in or create your Roku account, theTVgets an acknowledgment and adds yourpre-existing streaming channels, if any, to your TV. This process is automatic and takes a few moments—a little longer if you already have a lot of streaming channels to add. TIP: Streaming channels from all Roku devices associated with your account are synchronized periodically, so all of your Roku devices have the same streaming channels(subject to compatibility with the device). After it adds your selected streaming channels, the TV helps you set up the devices that you’re connecting to it, such as a cable box, Blu-ray player, or game console: 9.Press [OK]or [RIGHT]to proceed: Why do I need a RokuAccount? You need a Roku account for several reasons. • It links you, your TV, your other Roku devices, the Roku web site, and a payment method. • Fees associated with adding certain channels are paid for by the payment method you have specified. • Streaming content providers know that it’s OK to send content you request to your TV. • Roku can automatically send updates to your device. Important: It doesn’t cost anything to use your TV, and there are lots of free channels. If you choose to add a streaming channel or other application with associated fees (most have none), it’s paid for by the payment method you have specified. Guided Setup 10 10. Connect all the devices you plan to use to the TV, turn them all on, and then select Everything is plugged in and turned on . TheTV now takes you step by step through each of its inputs and asks what kind of device you have connected. On each input that has a connected and active device, you can see its picture and hear its sound. 11. Press [UP] or [DOWN]to highlight the label you want to associate with the input, and the press [OK]to move on to the next input. You’re done with Guided Setup. NOTE • Some Roku TVs, depending on where you live and other factors, show you an introductory videofilled with some great hints and tips. If you’re not interested in viewing this video, press on theremote control to exit to the Roku TV Home screen. When you finish Guided Setup, and whenever you press [ ] on the remote control, the Home screen greets you. From here, you can explore everything your TV has to offer. Press the arrow buttons to move around, and press [OK] to select a highlighted item. We’ve designed theTV to encourage you to explore, and you can probably figure out most of the capabilities and settings on your own. If you have any questions or difficulties, you can find answers and solutions in this guide. If you find yourself a long way from the Homescreen, you can always get back right away by pressing one button: [ ] . Tip:The appearance of the Homescreen varies depending on whether you decided to connect your TV to the Internet. Guided Setup 11 Connected TV Home Screen Here is a typical Homescreen from a TV that’s connected to the Internet and paired with a Roku account. Personalize your Home screen You can do a lot to personalize your Homescreen and make it just right for you and your family: Add streaming channels by browsing the Roku Channel Store. Remove a tile by highlighting it and pressing [ ] . Reposition a tile by highlighting it and pressing [ ] . Rename a TV input tile by highlighting it and pressing [ ] . Change the screen theme to suit your mood. Highlighted item - press [OK]to select Press [ ] for options when available Hint - Press [RIGHT]to see another screen Streaming channels and applications Home menu TV inputs Guided Setup 12 Non-connected TV Home screen Here is a typical Homescreen from a TV that is not connected to the Internet. Personalize your Home screen You can do a lot to personalize your Homescreen and make it just right for you and your family: Remove a tile by highlighting it and pressing [ ] . Reposition a tile by highlighting it and pressing [ ] . Rename a tile by highlighting it and pressing [ ] . Add streaming channels by browsing the Roku Channel Store (after connecting the TV to the Internet to add the Streaming Channels option to the menu). Highlighted item - press [OK]to select Press [ ] for options when available Hint - Press [RIGHT]to see another screen Home menu TV inputs Benefits of connecting 13 Benefits of connecting Connecting brings out your TV’s full potential! Make any night a movie night Your TV offers more than 300,000 movies and TV episodes to choose from, across major streaming movie channels like Netflix,Amazon Instant Video, Hulu Plus, Redbox Instant, VUDU, and more.* Get in the groove Stream on-demand or live music from any of more than 85 music channels like Pandora, VEVO, Spotify, iHeartRadio, and more.Access your entire MP3 collection instantly withAmazon Cloud Player or the Roku Media Player. Explore loads of free trials Your TV comes packed with special offers, often including free trials from popular streaming channels likeAmazon Instant Video, Netflix, Redbox Instant, Spotify, and DailyBurn. Rule the water cooler Binge on the most buzzworthy shows on streaming channels like FOXNOW, HBO GO, Hulu Plus, and Netflix.* Live stream your sports team with the biggest selection of streaming sports packages out there, including WATCH ESPN, MLB.TV, NBA League Pass Broadband, NHLGameCenter, MLS LIVE, UFC, WWE, and more. International sports offerings on Dishworld include Indian Premier League cricket and Brazilian pro soccer. What is streaming? Streaming is viewing or listening to video or audio content that is sent over the Internet, or located on a network-connected media server or on a USB device plugged into the TV’s USB port. With streaming, you can watch most programs on demand, when it’s convenient for you. When streaming, you can play, pause, rewind, and fast forward whatever you are watching. You can also replay the last few seconds again, or turn on closed captions. Tip: Some content cannot be paused or skipped. For example, if you are viewing live programming or a program that is supported by ads, you generally are not allowed to skip the ads. Your TV lets you choose from over 3,000 streaming channels that offer a huge selection of entertainment: • Over 300,000 movies and TV episodes • Unlimited music, live and on-demand • Tons of live and on-demand sports • Commercial-free kids programming • International language programming in 22 languages • 24x7 news and in-depth news commentary • Games Most streaming channels are free. Some streaming channels likeAmazon Instant Video, Redbox Instant, and VUDU, let you purchase or rent the latest movie releases or popular TV series. Some channels such as Netflix or Hulu Plus charge a monthly subscription fee. Some channels are free if you subscribe to a companion service through your cable or satellite provider. For example, HBO subscribers with participating TV providers can add the HBO Go channel and watch it for free. If you have an existing subscription to a service like Netflix or Hulu Plus, or if you are anAmazon Prime member, you can just sign in with your existing user name and password. -------------------------------------------------------- * Subscriptions or other payments may be required to access content on certain channels. For example, Netflix requires a paid subscription, which gives you access to movie and TV show titles in the Netflix streaming catalog. Some channels may not be available to all households in every market or in all countries where Roku players or other products with the Roku platform are sold. 14 To play streaming content that is available on the Internet, you add streaming channels to your Homescreen.To add a streaming channel to your Homescreen, use the Streaming Channelsoption on the Homescreen menu to go to the Roku Channel Store, and then select the streaming channel you want to play. The streaming channel is then added to your Home screen, and you can watch it at any time. For more information on using the Roku Channel Store, see Using the Roku Channel Store on page 28 . NOTE • Some channels may not be available to all households in every market or in all countries where Roku TVs are sold. But what if I didn’t connect my TV? What if you went through Guided Setup and chose Connect to the Internet later ? No worries. Your TV makes it easy to connect whenever you want.As you move around the Homescreen, you’ll see several places where you can start the connection process. For example: Every now and then you’ll see a message appear on the panel to the right of the Homescreen offering a Connect Now option. Simply highlight and select the Connect Nowoption to get started. Use the Connect and activate nowoption in the Settingsmenu. From the Homemenu, select Settings, then Network , and then Connect and activate now. If you want to start over from the beginning, use the Settingsmenu to do a Factory reset, and then go through Guided Setup again. This time, choose your home network when prompted. Regardless of how you connect, the process is the same. If you need details, see Step 3 of Setting up your TV on page 6. Benefits of connecting 15 Setting upAntenna TV Despite all of the entertainment possibilities of your TV, you may also want to watch broadcast TV. You watch broadcast TV in much the same way you watch other entertainment choices. You select a tile—the Antenna TVtile—from the Homescreen. The first time you select the Antenna TVtile, you have to set up theTV tuner. Setting up the TV tuner scans for active channels and adds them to your channel list. Why do I have to set up the TV tuner? You might be asking, “Why is this step necessary?” Good question. Not everyone needs to use the TV tuner. For example, you might have a set top box provided by a cable or satellite company that receives all of your channels. Most of these set top boxes use an HDMI ® connection. More and more people are watching only streaming TV and do not have aTV antenna or cable/satellite service. If you don’t need the TV tuner, you can bypass setting it up and instead remove it from the Homescreen as explained in Remove unwanted tiles on page 30 . The TV scans the signals on its antenna input for channels with a good signal, and adds those to the channel list, skipping dead channels and channels with a very weak signal. The TV will, however, let you add channels with no signal if you have an older set top box, VCR, or game console that can only output a signal on analog channel 3 or 4. These are the only channels that can be added regardless of whether they have a good signal. Typically, you’ll only need one of these channels, but both are provided to make setup simpler. You can hide the one you don’t want as explained in Edit broadcast TV channel lineup on page 29. How do I set up the TV tuner? Setting up the TV tuner is easy—yourTV does most of the work. You just have to answer a couple of questions. 1.Make sure your antenna or other device is connected to the TV’s ANT/CABLEinput. 2.On the Homescreen, select the Antenna TVtile. 3.Read the simple on-screen instructions and select Start finding channels. 16 4. If prompted, select your time zone. You’ll only need to do this if the TV can’t figure out your time zone from your Internet connection. 5. When prompted, select whether to add analog channels 3 and 4 (to enable you to connect older set top boxes, VCRs, or game consoles). 6.Wait while your TV scans for broadcast (antenna TV) stations… Why does the TV need my time zone? The TV needs to know your time zone so that it can correctly display information about the program you are currently watching. Setting upAntenna TV 17 … and then cable TV channels. Tip: CableTV channels are channels from a cable TV provider that you can receive by connecting their cable directly to your TV (unscrambled NTSC,ATSC, and QAM channels, if you’re interested in the details). In many cases, your cable provider probably requires you to use their set-top box and connect it to a different input, and then use the set-top box to tune your cable stations. In that case, you can skip scanning for cable channels . 7.When the channel scans finish, the TV shows the number of channels it added. Scanning for channels can take several minutes. NOTE • You should plan to repeat the channel scan periodically to make sure you are receiving all of the latest channels. Broadcasters add and remove channels, move channels to different parts of the spectrum, and change the power levels of their channels periodically. You’ll also have to repeat the channel scan if you remove the Antenna TVtile from the Home screen or perform a factory reset. To repeat the channel scan at any time, go to Settings> TV inputs> Antenna TV > Scan again for channels. Now, you’re ready to watch broadcast TV! While you’re watching, try the following: Press [UP] or[DOWN] to change channels. Press [LEFT] to display the channel list and then use[UP] and[DOWN] to select a channel to watch. Or press[REVERSE] or [FORWARD] to jump a page at a time. Press [OK] to display information about the current program. Press [ ] to switch to the previously tuned channel. Press [ ] to see options for picture and sound settings. Remote control on page 19 has more information on using the remote control buttons while watching TV. Setting upAntenna TV 18 Using your TV This section provides information on using the day-to-day features of your TV. TV status light Your TV has a single status light on the front panel. It goes on and off and blinks in different ways depending on the status of the TV, as shown in the following table: TV conditionStatus indicatorMeaning On (screen is active) OffScreen is communicating that TV is on. Screensaver (screen is active) OffScreen is communicating that TV is on. Off (no power) OffTV does not have power. Off (standby)OnTV has power and is ready to use. Starting up from off stateSlow pulsing blink until startup completesTV is doing something. On (receiving update from USB)Slow pulsing blink until update completesTV is doing something. Remote control command receivedDims on/off onceTV has received your command. TV panel buttons The controls on the TV enable you to perform simple functions, but are not a substitute for the remote control. Your TV has seven buttons on theTV rear, if you need specific location, see Quick Start Guide.They perform the following functions: • Input • Channel + • Channel – • Volume + • Volume – • Mute • Power 19 Remote control TV IR remote control Getting around You’ve already done a bit of navigating with the remote control when you completed the Guided Setup and when you set up Antenna TV. This section explains how to use the remote control for everyday TV use. POWER If the TV is in ‘Standby’mode, turns power on. If the TV is on, putsTV in ‘Standby’ mode. BACK The action depends on what you are doing with the TV: • Menu : Goes back to previous menu/screen. • Home screen tile : Moves highlight back to the Home menu option. • Watching Antenna TV or a TV input : Returns to the screen from which the input was selected. • Playing streaming content : Stops playing stream and returns to the previous menu or screen. • Browsing streaming content : Goes to the previous level in the content tree. HOME Immediately returns to the Home screen menu. OPTIONS When the Options hint in the upper right corner of the screen is not dimmed, displays an Options menu. The menu you see varies depending on what you are doing with theTV. Also, in most cases, pressing [ ] while a video is playing displays an Options menu over part of the screen where you can adjust various picture and sound settings. Using your TV 20 UP Moves the highlight up one item. DOWN Moves the highlight down one item. LEFT Moves the highlight left, if possible (if a < hint appears). When watching TV, displays your channel list. When playing most streaming videos, skips backward in the video. RIGHT Moves the highlight to the right, if possible (if a > hint appears). When watching TV with the channel list displayed, dismisses the channel list. When playing most streaming videos, skips forward in the video. OK Selects the highlighted option. When watching TV, this button displays information for the current TV program. SCAN REVERSE When playing streaming video that supports this feature: • First press scans backward at 1x speed. • Second press scans backward at 2x speed. • Third press scan backward at 3x speed. • Subsequent presses cycle through 1x, 2x, and 3x reverse speed. When playing streaming audio, jumps to the previous track/selection. When any menu, tile, or channel in the channel list is highlighted, jumps up one page. When using a virtual keyboard, jumps to the character at the top of the current column. PLAY/ PAUSE When playing streaming content, alternately pauses and plays the content. SCAN FORWARD When playing streaming video that supports this feature: • First press scans forward at 1x speed. • Second press scans forward at 2x speed. • Third press scan forward at 3x speed. • Subsequent presses cycle through 1x, 2x, and 3x forward speed. When playing streaming audio, jumps to the next track/selection. When any menu, tile, or channel in the channel list is highlighted, jumps down one page. When using a virtual keyboard, jumps to the character at the bottom of the current column. JUMP BACK When playing streaming video that supports this feature, jumps back 7 seconds with each press and resumes playing. In some channels, if Closed captioningis set to Instant replay , captions are displayed during the duration of the jump back period only. When watching broadcast TV, jumps to previous channel. When using an on-screen keyboard, backspaces in the text you are entering. VOLUME UP Turns volume up one setting with each press. Press and hold to turn volume up rapidly.A volume indicator shows the volume level while you are adjusting the volume and for a few seconds afterward. NOTE • If the TV is muted, pressing VOLUME UPunmutes the sound. VOLUME DOWN Turns volume down one setting with each press. Press and hold to turn volume down rapidly. Avolume indicator shows the volume level while you are adjusting the volume and for a few seconds afterward. NOTE • If the TV is muted, pressing VOLUME DOWNdoes not unmute the sound. Using your TV 21 MUTE Mutes the TV sound.Avolume indicator shows the current volume level and a mute icon when you press this button and for a few seconds afterward. If Closed captioningis set to On mute , captions are displayed while the TV is muted. STREAMING CHANNEL SHORTCUT Dedicated buttons show the logo of a featured streaming content provider. Pressing a button turns on the TV, and if the TV is connected to the Internet, performs one of the first two following actions: • Displays the main page of the streaming channel if you have already added the channel to your Homescreen. • Displays the sign-up page for the streaming channel if you have not already added the channel so that you can agree to any terms and fees for the service. • If the TV is in ‘Standby’mode (off), turns theTV on.And, if it is connected to the Internet, the TV performs one of the first two actions listed above. NOTE • For information about using a Universal Remote, refer to the Other devices on page 42. Watching broadcast TV channels To watch broadcast TV, select the Antenna TVtile in the Homescreen. Your TV remembers the last channel you watched and starts with that channel playing. Tip:You also can use the buttons on the TV panel to selectAntenna TV, as explained in TV panel buttons on page 18. Changing channels To change channels, you can do any of the following: Press [UP] to change to the next higher channel. Press [DOWN] to change to the next lower channel. Press [LEFT] to display the channel list, and then press[UP] and[DOWN] to move the highlight through the list one channel at a time. Or press [REVERSE SCAN]and [FORWARD SCAN] to move the highlight through the list one page at a time. When you’ve highlighted the channel you want to watch, press [OK]. (If you decide you don’t want to change channels, press [RIGHT]or [BACK]). Press [ ] to jump to the previous channel. Press again to return to the channel you were watching before you pressed [] . Viewing program information To view information about the current program, press [OK]. The TV displays a banner at the bottom of the screen with as much information as is available in the program data stream. Program information, subject to availability, includes: • Channel number • Channel call sign • Signal strength Program information banner Using your TV 22 • Program title • Start time, end time, and graph of program length showing current position • Content rating • Video resolution (480i, 480p, 720p, 1080i, 1080p) • Audio quality (Mono Dolby Digital, Stereo Dolby Digital, 5.1 Dolby Digital, Dolby Digital+) • Audio features (SAP/MTS) • Closed captioning (CC) • Current time • Program description. If the entire description does not fit, press [OK]to expand the size of the banner and see the entire description. Adjusting settings Press [ ] to display the Options menu. Press [UP] and [DOWN] to highlight an option, and then press [LEFT] and [RIGHT] to change the setting. Adjusting TV settings on page 24explains each of the settings in detail. Switching TV inputs Switch to a TV input to access the device connected to that input (for example, a Blu-ray player). Switching inputs is as simple as highlighting the input’s tile in the Home screen, and pressing[OK] . The video signal on the input, if any, appears on the screen. Tip:You also can use the buttons on the TV panel to select a TV input, as explained in TV panel buttons on page 18. Customizing your TV on page 29 explains how to rename and remove inputs. Auto-detecting devices Your TV automatically detects when you connect a new device to an HDMI input and turn on its power. The input is automatically added to the Homescreen if it isn’t already present. Adjusting audio/video settings While watching video content on any input, press [ ] to display the Options menu. Press [UP] and [DOWN] to highlight an option, and then press [LEFT]and [RIGHT]to change the setting. Adjusting TV settings on page 24explains each of the settings in detail. Using your TV 23 Playing content from USB storage devices Your TV has a USB port that can be used to play personal music, video, and photo files from a USB flash drive or hard disk. If your TV is connected to the Internet, your Homescreen has the Roku Media Playertile. If yourTV has not been connected to the Internet, the Homescreen has the USB Media Playertile. To use this feature, first make sure your media files are compatible with the Roku/USB Media Player.As of the publication date of this guide, the following media file formats are supported: • Video – MKV (H.264), MP4, MOV (H.264),TS (H.264) • Music –AAC, MP3, WMA, WAV (PCM),AIFF, FLAC,AC3, and DTS* • Photo – JPG, PNG, GIF To see the latest list of supported formats, view Helpin the Media Player. The Roku/USB Media Player displays supported file types only, and hides file types it knows it cannot play. Playing content from local network media servers If you have connected your TV to a network, it can play personal video, music, and photo files from a media server on your local network. Media servers include personal computers running media server software such as Plex or Windows Media Player, network file storage systems that have built-in media server software, and other devices that implement the specifications of the Digital Living NetworkAlliance. Some servers do not fully implement the DLNAspecification but are UPNP (Universal Plug and Play) compatible. The Roku Media Player will connect to them as well. Some media servers can convert files into Roku compatible formats. DRM-protected content is not supported.
https://usermanual.wiki/Hisense-Electric/LCDC0036.W9HLCDC0036-User-Manual-3/html
Rasulpara Branch Post Office, Junagadh 40, Gujarat Get Rasulpara post office address, pincode, phone number, Rasulpara speed post tracking, saving scheme and location map. Rasulpara Post Office, Junagadh Rasulpara Post Officeis located at Rasulpara, Junagadhof Gujarat state. It is a branch office (B.O.). A Post Office (PO) / Dak Ghar is a facility in charge of sorting, processing, and delivering mail to recipients. POs are usually regulated and funded by the Government of India (GOI). Pin code of Rasulpara POis 362140. This Postoffice falls under Junagadh postal division of the Gujarat postal circle. The related head P.O. for this branch office is Junagadh head post office and the related sub-post office (S.O.) for this branch office is Akolvadi post office. Rasulpara dak ghar offers all the postal services like delivery of mails & parcels, money transfer, banking, insurance and retail services. It also provides other services including passport applications, P.O. Box distribution, and other delivery services in Rasulpara. The official website fo this PO is http://www.indiapost.gov.in. Types of Post Offices are basically classified into 3 types, namely – Head Post Office, Sub-Post Office including E.D. Sub-Office and Branch Postoffice. Rasulpara P.O. is a Branch Post Office. So far as the public is concerned, there is basically no difference in the character of the service rendered by Sub-Post Offices and Head-Post Offices except in regard to a few Post Office Savings Bank (SB) transactions. Certain Sub Post Offices do not undertake all types of postal business. Facilities are generally provided at Branch Post Offices for the main items of postal work like delivery and dispatch of mails, booking of registered articles and parcels accepting SB deposits and effecting SB withdrawals, and issue and payment of money orders, though in a restricted manner. Post Office Type Head Post Office Sub-Post Offices including E.D. Sub-Offices Branch Post Office Rasulpara Post Office & Its Pin Code Branch Office Information Rasulpara Post Office Services Mail Services Parcels Retail Services Premium Services Speed Post India Post Speed Post Tracking Tracking System India Post Tracking Number Formats Express Parcel Post Media Post Greetings Post Logistics Post ePost Office Financial Services Savings Bank (SB) Account Recurring Deposit (RD) Account Monthly Income Scheme (MIS) Monthly Public Provident Fund (PPF) Time Deposit (TD) Senior Citizen Saving Scheme (SCSS) National Savings Certificate (NSC) Kisan Vikas Patra (KVP) Sukanya Samriddhi Accounts (SSA) Post Office Timings India Post Tracking Rasulpara Post Office Recruitment Location Map Contact Details About India Post Rasulpara Post Office & Its Pin Code Often Post Offices are named after the town / village / location they serve. The Rasulpara Post Office has the Postal Index Number or Pin Code 362140. A Pincode is a 6 digit post code of postal numbering system used by India Post. The first digit indicates one of the regions. The first 2 digits together indicate the sub region or one of the postal circles. The first 3 digits together indicate a sorting / revenue district. The last 3 digits refer to the delivery post office type. P.O. Name Rasulpara PO Pincode 362 140 The first digit of 362140 Pin Code '3' represents the region, to which this Post Office of Rasulpara belongs to. The first two digits of the Pincode '36' represent the sub region, i.e, Gujarat. The first 3 digits '362' represent the post-office revenue district, i.e, Junagadh. The last 3 digits, i.e, '140' represent the Rasulpara Delivery Branch Office. Branch Office Information The Rasulpara Post Office is a branch office. The Delivery Status for this PO is that it has delivery facility. Postal division name for this Dak Ghar is Junagadh, which falls under Rajkot region. The circle name for this PO is Gujarat and it falls under Junagadh Taluka and Junagadh District. The state in which this Dakghar is situated or located is Gujarat. The related head postoffice is Junagadh post office and the related sub post office is Akolvadi post-office. The phone number of Rasulpara post office is unavailable at present. PO Type Branch Office Delivery Status Delivery Postal Division Junagadh Postal Region Rajkot Postal Circle Gujarat Town / City / Tehsil / Taluka / Mandal Junagadh District Junagadh State Gujarat Related Sub PO Akolvadi Sub Office Related Head PO Junagadh Head Post Office Rasulpara Post Office Services Traditionally the primary function of Rasulpara post office was collection, processing, transmission and delivery of mails but as of today, a Post Office offers many other vital services in addition to its traditional services. The additional services provided by a Dak Ghar include – Mail Services, Financial Services, Retail Services and Premium Services. Mail Services Mail Services are the basic services provided by Rasulpara P.O. Mails and mail services include all or any postal articles whose contents are in the form of message which may include Letters, Postcards, Inland letter cards, packets or parcels, Ordinary mails etc. Parcels Mail Service also includes transmission and delivery of Parcels. A parcel can be anything ranging from a single written letter or anything addressed to an addressee. No parcel shall be by any chance be in a shape, way of packing or any other feature, such that it cannot be carried or transmitted by post or cause serious inconvenience or risk. Every parcel (including service parcels) that needs to be transmitted by post must be handed over at the window of the post office. Any parcel found in a letter box will be treated and charged as a registered parcel. Delivery services are provided by some selected delivery and branch post offices. This dakghar have the facility of delivery, thus the people of Rasulpara and nearby localities can avail all the types of mail services. Retail Services Post offices in India serve in various ways and Rasulpara Post Office offer most of the retail services. They offer the facility to accept or collect constomer bills like telephone or mobile bills, electricity bills for Government and private organizations through Retail Post. Some of the aditional agency services that Post offices offers through retail services are as follows - Telephone revenue collection, e-Ticketing for Road Transport Corporations and Airlines, Sale of UPSC forms, university applications, Sale of Passport application forms, Sale of Gold Coins, Forex Services, Sale of SIM and recharge coupons, Sale of India Telephone cards, e-Ticketing of Railway tickets etc. The postal customers of Rasulpara can pay their bills and avail other retail services from this Dak Ghar. Premium Services Most of the premium services can be availed by the Rasulpara peoples and nearby living people. The premium services provided by Rasulpara Post Office are - Speed Post, Business Post, Express Parcel Post, Media Post, Greeting Post, and Logistics Post. Speed Post Speed Post is a time bound service in express delivery of letters and parcels. The max weight up to which an article or parcel be sent is 35 kgs between any two specified stations in India. Speed Post delivers 'Value for money' to everyone and everywhere, delivering Speed Post upto 50 grams @ INR 35 across the country and local Speed Post upto 50 grams @ INR 15, excluding applicable Service Tax. Kindly check official website for updated Speed Post service charges. India Post Speed Post Tracking Speed Post offers a facility of on-line tracking and tracing that guarantees reliability, speed and customer friendly service. Using a 13 digit barcode that makes a Speed Post consignment unique and identifiable. A web-based technology (www.indiapost.gov.in/speednettracking.aspx) helps the Rasulpara customers track Speed Post consignments from booking to delivery. Tracking System Except Speed Post, India Post also allows people to track their order information for certain products like Parcels, Insured letters, Speed Post, Registered Post, Electronic Money Orders (EMO) and Electronic value payable parcel (EVPPs) etc. The tracking number is available on the receipt given at Rasulpara Post Office. Using the tracking number postal customers can find out the date and time of dispatch of an article at various locations. The time of booking and the time of delivery of article. India Post Tracking Number Formats Different types of postal service have different kinds of tracking number formats. The tracking number for Express Parcel is a 13 digit alphanumeric format. The format for Express Parcel is XX000000000XX. The tracking number for a Registered Mail is a 13 digit alphanumeric number and its format is RX123456789IN. But a Electronic Money Order (EMO) has a 18 digit tracking number and its format is 000000000000000000. For domestic Speed Post (EMS) there is a 13 digit alphanumeric tracking number with the format EE123456789IN. Bharatiya Dak Ghar Seva Tracking Number Format Number of Digits Electronic Money Order (eMO) 000000000000000000 18 Express Parcel XX000000000XX 13 International EMS Artilces to be delivered in India EE123456789XX 13 Registered Mail RX123456789IN 13 Speed Post (EMS) Domestic EE123456789IN 13 Express Parcel Post In Express Parcel Post, the Rasulpara postal customer gets time bound delivery of parcels. These parcels will be transmitted through air or any other fastest mean available at that time. Minimum chargeable weight for which Express Parcel consignments will be booked is 0.5 Kg. Maximum weight of Express Parcel consignments which shall be booked across the Post Office counter by a retail customer shall be 20 Kg and maximum weight that can be booked by corporate customer is 35 kgs. Media Post India Post offers a unique way or concept to help the Indian corporate organisations and the Government organizations reach potential customers through media post. Through media post people can advertise on postcards, letters, aerogramme, postal stationary etc. Customers get to see the logo or message of the respective corporate or government organizations. The Aerogramme even gives the organizations the opportunity to make their product have a global impact. Greetings Post Greeting Post is yet another innovative or unique step by India Post. It consists of a card with an envelope with pre-printed and pre attached postage stamp on the envelope. The stamp on the envelope is a replica of the design that appears upon the card but in miniature form. Thus there is no need affix postage stamps on the envelope implicitly saving your time of going to post offices and standing in the queue. All the rules and that are applicable for the postage dues will also be applicable to the Greeting Post. Logistics Post Logistics Post manages the entire transmission and distribution side of the parcels. It deals with collection of goods, storage of goods, carriage and distribution of the various parcels or goods, from order preparation to order fulfilment. And that too at the minimum possible price. Logistics Post services provides the Rasulpara postal customer with cost-effective and efficient distribution across the entire country. ePost Office The advent of internet made communication very rapid through emails. But, the internet has not yet reached most of the rural parts of India. To change this division between rural & urban life, and to get the benefit of internet technology to Rasulpara people's lives, Indian Postal Department has introduced e-post. e-post is a service in which personalized handwritten messages of customers are scanned and sent as email through internet. And at the destination address office, these messages are again printed, enveloped and delivered through postmen at the postal addresses. E-post centres are established in the Post Offices, covering a large geographical area including major cities and districts. These e-post centres are well equipped with internet connection, scanners, printers and other necessary hardware equipment. However, this e-post service doesn’t particularly need a e-post centre, but can this facility can be availed at any normal Post Office or you can visit www.epostoffice.gov.in to access postal services on your desktop, laptop or even on mobile. If a message is booked at Rasulpara post office, the post is scanned and sent to an e-post centre by e-mail and a mail received at e-post centre is printed and sent to nearby Post Office for dispatch. A Rasulpara customer can also avail these services of an e-post, at his/ her home. All he/ she has do is to register as a user at www.epostoffice.gov.in website. After registration, a user can use e-post by scanning and sending messages, printing and receive messages. The message to be scanned must not be written in a paper not more A4. There is no limit for sending number of sheets of messages in e-post. E-Post Office offers certain services like – Philately, Postal Life Insurance, Electronic Indian Postal Order, Information Services, Track & Trace and Complaints & Guidelines services. Philately Philately service deals with collection, sale and study of postage stamps. Philately includes lot of services Philately Information, Stamp issue Program, Stamps List and Buy Stamps service. Postal Life Insurance (PLI) A service offered by the Government to pay a given amount of money on the death of an individual to his prescribed nominee. The amount may also be paid to the person himself, in case he survives that maturity period. The two services offered under Postal Life Insurance are – Pay Premium service and PLI information. Electronic Indian Postal Order eIPO or Electronic Indian Postal Order is a facility to purchase an Indian Postal Order electronically by paying a fee on-line through e-Post Office. This service is launched by the Department of Posts, Ministry of Communications & IT, Government of India. eIPO can now be used by Indian Citizens living in India for paying online fee, whoever seeks information under the RTI Act, 2005. eIPO offers 2 types of services – eIPO information and payment of online fees. Information Services This helps Rasulpara customers to get information regarding certain products like – Pin Code search, Speed post, Banking, Insurance, Business Post, Logistics Post, IMTS and many more other services. Track & Trace The track & trace service is very helpful as it aids in getting information of our valuables. Track & Trace service offers 5 different services – Pin Code search, EMO tracking, Speed Post tracking, WNX tracking and International mail service. Complaints & Guidelines Using e-post office service Rasulpara postal costumer can access services based on – complaint registration, complaint status and guidelines on complaints. ePost Office Website www.epostoffice.gov.in Financial Services The customers of Rasulpara can enjoy the various savings schemes available in this post office that prove to be highly beneficial for the people living in Rasulpara area. The Financial service offered by PO includes Savings and Postal Life Insurance (PLI). There are various options available to save and invest with post-offices. The commonly used ones include - Savings account, Recurring Deposit, Monthly Income Scheme, Monthly Public Provident Fund, Time Deposit, Senior Citizen Saving Scheme, National Savings Certificate, Kisan Vikas Patra and Sukanya Samriddhi Yojana. Post Office also offers Insurance product through Postal Life Insurance (PLI) and Rural Postal Life Insurance (RPLI) schemes that offer low premium and high bonus. Post Office Financial Services Kisan Vikas Patra (KVP) Monthly Income Scheme (MIS) Monthly Public Provident Fund (PPF) National Savings Certificate (NSC) Recurring Deposit (RD) Account Savings Bank (SB) Account Senior Citizen Saving Scheme (SCSS) Sukanya Samriddhi Accounts (SSA) Time Deposit (TD) Savings Bank (SB) Account A Savings bank account serves the need of regular deposits for its customers as well as withdrawals. Cheque facility is also avail by Rasulpara postal consumers. Recurring Deposit (RD) Account A post office offers a monthly investment option with handsome return at the time period with an option to extend the investment period. Insurance facility is also available with certain conditions. Monthly Income Scheme (MIS) MIS offers a fixed investment technique for five or more years with monthly interest payment to the account holder. There is also a facility of automatic crediting of interest to SB account of the Rasulpara postal customer. Monthly Public Provident Fund (PPF) This service offers intermittent deposits subject to a particular limit for a time period of 15 years with income tax exemptions, on the investment. It also offers loan and withdrawal facilities for the postal customers. Time Deposit (TD) Fixed deposit option for periods ranging from one, two, three to five years with facility to draw yearly interest offered at compounded rates. Automatic credit facility of interest to SB account. Senior Citizen Saving Scheme (SCSS) Offers fixed investment option for senior citizens for a period of five years, which can be extended, at a higher rate of interest that are paid in quarterly instalments. National Savings Certificate (NSC) NSC is offered with a fixed investment for 5 or 10 years on certificates of various denominations. Pledging facility available for availing loan from Banks. Kisan Vikas Patra (KVP) Kisan Vikas Patra is a saving certificate scheme in which the amount Invested doubles in 110 months (i.e. 9 years & 2 months). It is available in denominations of Rs 1,000, 5000, 10,000 and Rs 50,000. Minimum deposit is Rs 1000/- and there is no maximum limit. The KVP certificate can be purchased by any adult for himself or on the behalf of a minor. This certificate can also be transferred from one account holder to another and from one post office to another. This certificate can be en-cashed only after 2 and 1/2 years from the date of issue. Sukanya Samriddhi Accounts (SSA) Sukanya Samriddhi Account Yojana offers a small deposit investment for the girl children as an initiative under 'Beti Bachao Beti Padhao' campaign. This yojana is to facilitate girl children proper education and carefree marriage expenses. One of the main benefits of this scheme is that it is very affordable and offers one of the highest interest rates. Currently its interest rate is set as 8.6% per annum that is again compounded yearly. The minimum deposit allowed in a financial year is INR. 1000/- and Maximum is INR. 1,50,000/-. Subsequent deposits can be made in multiples of INR 100/-. Deposits can be made all at a time. No limit is set on number of deposits either for a month or a financial year. A legal Guardian can open an account in the name of a Girl Child. Account can be closed only after completion of 21 years of the respective child. The normal Premature closure allowed is after completion of 18 years only if that girl is getting married. Post Office Timings The official working hours of Post Offices vary from one another, but the general Post Office opening time starts from 08:00 AM or 09:00 AM or 10:00 AM and the closing time is 04:00 PM or 05:00 PM or 06:00 PM respectively. The working days are from Monday to Saturday, Sunday being a holiday. This doesn't include the public holidays or the extended working hours. You can verify the working hours of Rasulpara Branch Post Office from the official resources. India Post Tracking Online tracking of India Post allowed Rasulpara people to access their postal article tracking information and confirm the delivery of their postal article by using the tracking number assigned to them at the time of Booking. They can find the tracking number on the Postal acknowledgement handed over to them at the Rasulpara Branch Post Office counter at the time of postal article booking. Following items can track through the www.indiapost.gov.in/articleTracking.aspx official website. Business Parcel Business Parcel COD Electronic Money Order (e-MO) Electronic Value Payable Parcel (eVPP) Express Parcel Express Parcel COD Insured Letter Insured Parcel Insured Value Payable Letter Insured Value Payable Parcel International EMS Registered Letter Registered Packets Registered Parcel Registered Periodicals Speed Post Value Payable Letter Value Payable Parcel The India Post tracking system is updated at regular intervals to give the Rasulpara postal customers with the most up to date information available about the location and status of their postal article. They'll be able to find out the following: When their postal article was booked When their postal article was dispatched at various locations during its Journey When their postal article was received at various locations during its Journey When their postal article was delivered, or When a delivery intimation notice was issued to notify the recipient that the postal article is available for delivery Rasulpara Post Office Recruitment For latest Rasulpara post office recruitment kindly visit www.indiapost.gov.in/recruitment.aspx. Location Map Rasulpara Branch Post Office is located in Rasulpara, Junagadh. Contact Details All the queries or complaints regarding Bill Mail Service, Booking Packets, Business Post, Direct Post, Flat Rate Box, Indian Postal Orders, Inland Letters, Instant Money Orders, Insurance of Postal Articles, Insurance of Postal Parcels, Letters, Logistics Posts, MO Videsh, Money Orders, Parcels, Post Office Savings Bank, Postal Life Insurance, Postcards, Registration of Postal Articles, Registration of Postal Parcels, Rural Postal Life Insurance, Saving Certificates, Small Saving Schemes, Speed Post, Value Payable Post etc.services in Rasulpara Post Office, can be resolved at Rasulpara Branch Post Office. You can send letters to "Postmaster, Rasulpara Branch Post Office, Rasulpara, Junagadh, Gujarat, India, Pincode: 362 140". The official website of the Berhampur University Sub Office is http://www.indiapost.gov.in. Rasulpara Branch Office Address: Rasulpara Branch Post Office, Rasulpara, Junagadh , Gujarat , India Pin Code: 362140 Website: www.indiapost.gov.in About India Post India Postis a government-operated postal system, which is part of the Ministry of Communications and Information Technology of the Government of India. It has the largest Postal Network in the Indiawith over 154882 Post Offices. There are around 139182 Post Offices in the rural India and 15700 Post Offices in urban India. The individual post office serves an area of 21.22 Sq. Km. and a population of 8221 people. The slogan of India Post is Dak Seva Jan Seva. There are 25464 departmental post offices and 129418 extra-departmental branch post offices in India. Rasulpara Post Office Summary Dak Ghar Name Rasulpara Branch Post Office Pincode 362140 Dakghar Type Branch Office Post Office Delivery Status Delivery Branch Office Postal Division Junagadh Postal Region Rajkot Postal Circle Gujarat Location Rasulpara District Junagadh State Gujarat Country India Related Sub Office Akolvadi Sub Office Related Head Office Junagadh Head Post Office Website www.indiapost.gov.in ePost-office Web Site Address www.epostoffice.gov.in Speed Post Tracking Website www.indiapost.gov.in/speednettracking.aspx Recruitment Web Site Address www.indiapost.gov.in/recruitment.aspx Other Post Offices
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The 8 Best Tandem Kayaks of 2023 The best tandem kayaks should be efficient and comfortable. We researched top options to have for your next ride on the water. Outdoors The Best Tandem Kayaks for a Smooth Ride TripSavvy / Chloe Jeong If you’re looking to spend some time out on the water with a friend, family member, or significant other, a tandem kayak is a great option. Unlike most kayaks, tandems are built for two people, making the experience a much more communal one. They’re also a great choice if space is at a premium since you can buy one kayak for two people. Another reason to go with a tandem kayak is when a stronger paddler wants to go out with a weaker paddler, such as a beginner heading out with an expert or a child heading out with a parent. But two-person kayaks come with a few compromises compared to the smaller, more maneuverable single-person boats. While sharing your kayak with another person can be a lot of fun, tandem models tend to be considerably longer and harder to control than standard kayaks. Kyle McKenzie, owner of Adventure Paddle Tours in Frisco, Colorado, and Naples, Florida, says, “With beginner kayakers not knowing their responsibilities, they tend to blame one another for the zig-zagging. It can be difficult for couples and siblings.” However, tandem kayaks can be faster and more stable when the paddlers know what they’re doing, making it easier for two paddlers to go further than they would on their own. Plus, they turn what is often a solitary sport into something you can share with others. Read on to learn more about the best tandem kayaks available. The Rundown Best Overall: Ocean Kayak Malibu Two XL Tandem Kayak at Backcountry.com Best Value: Intex Explorer K2 Inflatable Kayak Set at Amazon Best Inflatable: Advanced Elements Island Voyage 2 at Walmart Best Sit-on-Top: Ocean Kayak Malibu Tandem Kayak at Amazon Best for Lakes: Brooklyn Kayak Company PK14 at Brooklynkayakcompany.com Best for Fishing: Feelfree Lure 11.5 V2 Fishing Kayak at Ecofishingshop.com Best for Whitewater: Aire Lynx II Inflatable Kayak at Backcountry.com Best for Touring: Aquaglide Deschutes 145 Kayak at Backcountry.com Jump to Review Table of contents Our Picks What to Look For FAQ Why Trust Tripsavvy Best Overall Ocean Kayak Malibu Two XL Tandem Kayak 2022 Ocean Kayak What We Like Good for beginners Fast Comfortable for tall people Versatile What We Don't Like Seats are a little awkward Ocean Kayak's Malibu 2XL kayak is our top pick because it's ready for almost any water condition and is suitable for beginners and intermediates alike. This 13-foot-4-inch kayak is a bit longer than others on our list and has good traction and stability on flat water, light tides, or river currents. It's a value kayak that stays in the three-digit price range but still offers the quality expected from this respected kayak brand and a 5-year warranty to back the name. You also get the versatility of converting it for paddling solo, so you're not limited to times when you only have two paddlers. Simply remove one of the Comfort Plus seats and position the other one in the center of the boat. Since these seats are adjustable, this kayak can be used by anyone in the family, regardless of size. It weighs 68 pounds and can hold up to 475 pounds. Price at time of publish:$1,050 Capacity:475 pounds |Dimensions:160 x 34 inches |Inflatable:No Best Value Intex Explorer K2 Inflatable Kayak Set Courtesy of Amazon What We Like Adjustable backrest Comfortable Affordable What We Don't Like Intended for lakes only This two-person inflatable is far from a performance kayak, but for those looking to get into the sport at a budget-friendly price, this simple tandem fits the bill. As an inflatable, it’s much easier to transport and store than a hard-hull kayak and pumps up quickly, making it more realistic for newbies. The stiffness and performance are the limitations of this affordable option. Because it’s a lower-pressure inflatable and everything down to the seats is inflatable, the kayak lacks stiffness, which translates into stability, durability, and comfort issues. While the durability and performance of this entry-level tandem aren’t going up to the level of pricier options, it’s a great way to get into the sport on the cheap and find out if it’s for you. Price at time of publish:$170 Capacity:400 pounds |Dimensions:120 x 36 inches |Inflatable:Yes Best Inflatable Advanced Elements Island Voyage 2 Courtesy of L.L. Bean What We Like Multiple seat options Good stability Removable deep tracking fin What We Don't Like A little snug Fabric can be hard to clean Many tandem kayaks are so long that they are difficult, if not impossible, to transport without a large truck or roof rack. Inflatables such as this one open up kayaking to those with smaller cars or those who want to take their kayak on a plane without using up all their storage space. The Advanced Elements Voyage 2 is made of durable 600D polyester and measures 11 feet 2 inches in length so that paddlers won't be cramped. Multiple seat positions allow you to use it as a tandem or a solo kayak, and the boat's pontoon-style side tubes make for a stable kayak that's great for beginners. This kayak also features a rear drain plug for easy deflating. However, shoppers should note that you must buy the inflation air pump separately. Price at time of publish:$550 Capacity:400 pounds |Dimensions:132 x 37 inches |Inflatable:Yes Best Sit-on-Top Ocean Kayak Malibu Tandem Kayak Courtesy of Backcountry What We Like Comfy footbeds Storage space What We Don't Like Not as fast This sit-on-top kayak from OC Paddle features a rigid polyethylene frame that delivers efficient power transfer from your paddle strokes so you can paddle longer distances easily. It measures 12 feet in length and can comfortably hold two adults and one child. The two Comfort Plus seats are located in the bow and stern, and the middle seat has footbeds for added comfort. The molded frame features two gear straps for storing accessories, two handles, and a drain plug. Its maximum capacity is 375 pounds. Price at time of publish:$830 Capacity:375-425 pounds |Dimensions:144 x 34 inches |Inflatable:No Cruise Along Easily With the Best Recreational Kayaks Best for Lakes Brooklyn Kayak Company PK14 Courtesy of Brooklyn Kayak Co. What We Like Versatile Easy to steer Hand controlled runner Fishing rod holders What We Don't Like Expensive Could use more storage Heavy You can paddle long distances on the lake with Brooklyn Kayak Company's PK14 kayak. This sit-on-top kayak comes with two collapsible aluminum paddles and two pedal drives, giving kayakers the option to use either their hands or feet to maneuver the boat. It also features a hand-controlled rudder next to the rear seat, providing optimal steering and control. Unlike many cheaper kayaks, the PK14 has seats that have a rigid frame with padding so you can stay on the water longer without discomfort. Details aren't forgotten here, either, with a cup holder, three fishing rod holders, a storage hatch, a recessed cargo area, and four carrying handles. There's even an attachment point for an optional trolling motor to turn this into a boat/kayak hybrid. This kayak measures 14 x 34 inches and can carry up to 670 pounds. It also comes with a 5-year limited warranty. Capacity:670 pounds |Dimensions:168 x 34 inches |Inflatable:No Best for Fishing Feelfree Lure 11.5 V2 Fishing Kayak Courtesy of Theyakshak What We Like Stable Camouflaged Comfortable What We Don't Like Expensive Heavy The Feelfree Lure II is built for fishing. Designed to hold all your gear, this kayak has rear storage space for storing a cooler, front and rear rod holders, and a sonar pod to mount a fish finder. It also comes in five different camouflage colorways for maximum concealment as you glide into fish-heavy waters. This versatile kayak also offers multiple configuration options to give you more flexibility. The two Gravity seats are well-made and supportive to ensure you don't mind long days casting in the saddle. The seats are also removable, so you can convert this boat into a one-person kayak with more space to hold your gear and additional standing room. There's even an option to attach a motor or pedal behind the rear seat, converting this kayak into a serious fishing boat. Price at time of publish:$1,699 Capacity:500 pounds |Dimensions:168 x 36 inches |Inflatable:No Best for Whitewater Aire Lynx II Inflatable Kayak Courtesy of Aire What We Like Good maneuverability Stable Easy to transport What We Don't Like Expensive Aire is among the most respected names in river running crafts, and this agile tandem whitewater steed lives up to its reputation. The Lynx II is designed to be used in whitewater conditions, but it can also convert to a larger solo kayak with plenty of room for storing your stuff on an overnight river trip. The kayak is loaded with 17 cargo loops for securely lashing your stuff down when the water gets turbulent. It also has two grab handles on both sides underneath the boat that can be used to easily tip the boat back over if you capsize. The kayak's rockered bow and continuous curve shape make it ready to charge every rapid and eddy. This boat comes with a complete repair kit and a 10-year warranty. Capacity:475 pounds |Dimensions:150 x 39 inches |Inflatable:Yes Best for Touring Aquaglide Deschutes 145 Kayak Courtesy of Backcountry View On Backcountry.com View On Dick's View On L.L.Bean What We Like Versatile Ton of storage space Packable What We Don't Like Pump not included Expensive The Aquaglide Navarro is ready for whatever the elements throw at it. Made from 600-denier hexcell ripstop polyester and having a hard bottom drop-stitched floor, it's durable enough that river rocks won't damage it, despite being inflatable. If you need to access the zippered cargo holds on the bow or stern or get out gear from dry sacks held in the bungee decklace rigging, there are holders on either side of the vessel to secure your paddles. And if you want to take your kayak on a trip, it can easily be deflated and stored in a duffle-style carry bag tossed in a car or checked as luggage on a flight. There's also an optional zip-in closed deck cover for those looking for a bit of extra protection from waves. Capacity:500 pounds |Dimensions:172 x 39 inches |Inflatable:Yes What to Look for in a Tandem Kayak Stability The most frustrating thing for a beginner is a kayak they can’t keep upright. McKenzie says he buys lots of barely used fancy lightweight kayaks from people that realize their abilities aren’t up to the task. For beginners, a flat-bottomed kayak provides more stability when at rest and is a better choice for newbies. More advanced users will prize performance over flatwater stability—just be sure which level of kayaker you are before you buy. As McKenzie advises, “If you’re a beginner golfer, you wouldn’t use Tiger Woods’ golf clubs.” Length Longer kayaks often plane better than shorter ones, but this is an important dimension to consider in terms of storage and transport. Tandems can be longer than is convenient. Even if a 15-foot kayak performs excellently, it won’t be of much use to you if it’s too large to carry on your vehicle or to store in your garage. Check the specific dimensions listed by the manufacturer and then try to estimate if it will work with your size limitations for transporting and storing it. Support If you plan to spend extended time on your kayak, carefully evaluate the seating. Many kayak seats are flimsy and supported only by straps. Hard frame chairs offer better support when paired with a proper cushion. Capacity Kayak capacity is usually measured in weight; for a tandem kayak especially, it can be a good shorthand for how equipped a particular kayak is for true tandem use. If you and/or your kayaking partner are larger, it’s important to confirm that a particular kayak is up to keeping you both afloat. Some smaller tandems are rated for up to 350 pounds. That means two 175-pound adults are pushing the limit of this kayak, which may be suitable for smaller folks or an adult and a child. On the other end of the spectrum, some larger kayaks can support up to 675 pounds meaning two large adults plus lots of gear could reasonably be carried. Make sure to check the weight limit before purchasing. Frequently Asked Questions What is appropriate clothes for kayaking? Those kayaking in fair summer weather and relatively warm waters may want to wear swim attire and enjoy getting wet occasionally. But no matter what is worn, a personal floatation device is a safety must. For those paddling in cold waters (even on hot days), it's a good idea to dress for that water temperature and may want to consider a wetsuit. Even when paddling in warm waters on warm days, it's a good idea to use the kayak's storage (or a dry bag) to bring along layer options since changes in weather and time of day can change conditions quickly. Is it possible to paddle a tandem kayak solo? Yes. Many tandem kayaks are set up to convert for single-paddler use. Kyle McKenzie, owner of Adventure Paddle Tours in Frisco, Colorado, and Naples, Florida, says many of his guides use tandem kayaks as singles for the stability and storage space. “Convertible tandem kayaks allow the kayaker to adjust the stern seat. You can push it usually a foot and a half up, which will evenly distribute weight,” says McKenzie. Is it possible to steer a tandem kayak with both people paddling? Paddling a tandem kayak is challenging because of the propensity to collide paddles. McKenzie says defining responsibilities can help avoid conflicts. "Kayakers in the front must let go and let the kayaker in the back do the steering. The back kayaker is supposed to follow the kayaker's pace in the front. It is definitely a team-building experience," he says. What are the drawbacks of a tandem kayak? The size can make it more challenging to transport to and from the water and make it more difficult to store when not in use. Additionally, a two-person kayak often has less overall space to carry gear than two individual boats would have, which can be an important consideration for those embarking on a longer paddling excursion. There are fewer options when shopping for tandem kayaks versus single kayaks as well, says McKenzie. What’s the difference between sit-on-top and sit-inside kayaks? Sit-inside kayaks feature a sunken cockpit that usually permits a spray skirt that can be attached to exclude water that cinches around the rider's waist. These are most useful in whitewater and ocean kayaking but can be used on any kind of water with or without the spray skirt. Sit-on-top kayaks are better for warmer water and are well suited for fishing. Why Trust Tripsavvy Justin Parkis a Breckenridge, Colorado-based writer and videographer who has rafted whitewater, kayaked rivers, paddle-boarded high alpine lakes, and has learned to respect both wind and cold water living in the Rockies. He and his camera gear have survived Class III rapids. In compiling this list of best tandem kayaks, Park spoke withKyle McKenzie, owner ofAdventure Paddle Toursin Frisco, Colorado, and Naples, Florida. Thanks for letting us know! Newsletter Sign Up Newsletter Sign Up
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Medical & Psychological Genetics [Archive] - Eupedia Forum [Archive] Discuss genetic engineering, genetic diseases, gene therapy, cloning, genes associated with psychological traits... Cloning Chinese, Americans Truly See Differently, Study Says Would you try a gene therapy ? Malaria resistance and lazy genes Medical conditions and risk factors associated with mtDNA haplogroups Happy genes What part of us is genetically determined ? Medical conditions associated with Y-chromosome haplogroups Talking mice ? How human variant of speech gene changes a mouse's brain ABO blood group and disease resistance Negative Rh factor-implications? Male Ryukyu rat reproduces without a Y chromosome How much do genes control our behaviour ? Environmental DNA modifications tied to obesity City live helped humans evolve immunity to TB Gluten Intolerance/Celiac Serotonin transporter (SERT) gene linked to happiness, optimism and life satisfaction MAOA-L : Warrior Gene or Justice Gene ? 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Read this for a realistic explanation MENA countries and genetic variants for disease Genetics of Personality Development Genetic testing of embryos-Ethical considerations Ebola survivors still immune to virus after 40 years Finland To Sequence 10% (500,000) Of Its Population In 6 Years Gene editing staves off deafness in mice Weekly Fish Consumption Linked to Better Sleep and Higher IQ DNA-Based Flu Shot Researchers find clues to AIDS resistance in sooty mangabey genome Hepatitis B in 16th century Europe and HBV evolution Obesity linked to Mutations in ADCY3 Alcohol Damages DNA Fast-Food Causes Epigenetic Reprogramming in the Immune System Pathogen for Major Epidemic That Ravaged the Aztecs Simply Breathing Can Spread the Flu, New Study Suggests Gene Therapy is no longer a pipe dream A Virus-Like Protein is Important for Cognition and Memory Sensory sensitivity and autism Why aren't you a lefty? 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Viruses can evolve in parallel in related species Forecasts of genetic fate just got a lot more accurate Scientists discover gene controlling genetic recombination rates "All of Us": US Government seeking 1 million people for massive DNA & health study Scientists find fear, courage switches in brain The cerebellum and trial-and-error learning Researchers take key step toward growing human organs in laboratory Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress How human brains became so big 400 million year-old fish helps researchers understand HIV The Neurology of Spiritual Experiences Genetic risk for autism 'Gut instinct' may have been the GPS of human ancestors Y dna showing in a woman The evolution of juvenile susceptibility to infectious disease "Unfair twist of nature"? 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A genetic basis for insomnia Gene therapy cures infants with "Bubble Boy" immune disease The ape that understood the universe Risk scores for schizophrenia and bipolar disorder predict creativity. Gene editing fixes cystic fibrosis in mice Ratio of diabetes to prevalence of obesity Genome-wide differences in gene expression between male and female mammals Gene for finding things cute Immune System and Mental Health are connected Post your Worrier Versus Warrior results from yourdnaportal.com Dementia-Can you modify your risk? Psychiatric disorders and myelin thinning genes Genes and same sex behavior Extreme Inbreeding in the UK Biobank Chinese scientists attempt to cure HIV with CRISPR gene-editing Cure for lupus through genetic engineering? Local adaptation predicts type of psychiatric disorder? Testosterone and Gender Differences in Athlethics Man who had transplant finds out months later his DNA has changed to that of donor Gene-Editing to Disrupt both Latent and Active Herpes Virus Patterns in mate choice? Does having more boys than girls run in families? Native Americans show little selection at FADS locus HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 mtDNA up/downregulates autosomal genes related to cancer, methylation and immunity Influence of poverty on epigenome
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Expiry : 1 day Type : HTTP tentacle.solutions 1 141275_b Pending Expiry : 41 days Type : HTTP www.npg.org.uk npgimages.com 2 PHPSESSID [x2] Preserves user session state across page requests. Expiry : 6 days Type : HTTP Preferences 7 Preference cookies enable a website to remember information that changes the way the website behaves or looks, like your preferred language or the region that you are in. Cookiebot 1 Learn more about this provider CookieConsentBulkSetting-# Enables cookie consent across multiple websites Expiry : Persistent Type : HTML Shopify 1 Learn more about this provider currency Saves the visitor's currency preferences. Expiry : 1 year Type : HTTP Spotify 1 Learn more about this provider loglevel Maintains settings and outputs when using the Developer Tools Console on current session. Expiry : Persistent Type : HTML Vimeo 2 Learn more about this provider player Saves the user's preferences when playing embedded videos from Vimeo. Expiry : 1 year Type : HTTP sync_active Contains data on visitor's video-content preferences - This allows the website to remember parameters such as preferred volume or video quality. The service is provided by Vimeo.com. Expiry : Persistent Type : HTML npgshop.org.uk 2 keep_alive Saves the user's current geographical location based on the user's IP address. Expiry : 1 day Type : HTTP localization Holds the users timezone. Expiry : 1 year Type : HTTP Statistics 41 Statistic cookies help website owners to understand how visitors interact with websites by collecting and reporting information anonymously. Google 20 Learn more about this provider __utmc Registers a timestamp with the exact time of when the user leaves the website. Used by Google Analytics to calculate the duration of a website visit. Expiry : Session Type : HTTP _ga_# [x3] Used by Google Analytics to collect data on the number of times a user has visited the website as well as dates for the first and most recent visit. Expiry : 400 days Type : HTTP __utm.gif Google Analytics Tracking Code that logs details about the visitor's browser and computer. Expiry : Session Type : Pixel collect Used to send data to Google Analytics about the visitor's device and behavior. Tracks the visitor across devices and marketing channels. Expiry : Session Type : Pixel _ga [x3] Registers a unique ID that is used to generate statistical data on how the visitor uses the website. Expiry : 400 days Type : HTTP _gid [x3] Registers a unique ID that is used to generate statistical data on how the visitor uses the website. Expiry : 1 day Type : HTTP __utma Collects data on the number of times a user has visited the website as well as dates for the first and most recent visit. Used by Google Analytics. Expiry : 399 days Type : HTTP __utmb Registers a timestamp with the exact time of when the user accessed the website. Used by Google Analytics to calculate the duration of a website visit. Expiry : 1 day Type : HTTP _gat Used by Google Analytics to throttle request rate Expiry : 1 day Type : HTTP __utmt Used to throttle the speed of requests to the server. Expiry : 1 day Type : HTTP __utmz Collects data on where the user came from, what search engine was used, what link was clicked and what search term was used. Used by Google Analytics. Expiry : 6 months Type : HTTP _dc_gtm_UA-# [x3] Used by Google Tag Manager to control the loading of a Google Analytics script tag. Expiry : 1 day Type : HTTP National Portrait Gallery 1 Learn more about this provider cdn-cgi/images/trace/jsch/js/transparent.gif Registers statistical data on users' behaviour on the website. Used for internal analytics by the website operator. Expiry : Session Type : Pixel Neustar 1 Learn more about this provider ab This cookie is used by the website’s operator in context with multi-variate testing. This is a tool used to combine or change content on the website. This allows the website to find the best variation/edition of the site. Expiry : 1 year Type : HTTP New Relic 2 Learn more about this provider events/1/# Used to monitor website performance for statistical purposes. Expiry : Session Type : Pixel jserrors/1/# Pending Expiry : Session Type : Pixel Oracle 1 Learn more about this provider _at.hist.# Used by the social sharing platform AddThis to store the user's usage history of the AddThis sharing widget Expiry : Persistent Type : HTML Quantcast 12 Learn more about this provider _dlt [x3] Sets a unique ID for the session. This allows the website to obtain data on visitor behaviour for statistical purposes. Expiry : 1 day Type : HTTP __qca [x3] Collects data on the user's visits to the website, such as the number of visits, average time spent on the website and what pages have been loaded with the purpose of generating reports for optimising the website content. Expiry : Persistent Type : HTML __qca [x3] Collects data on the user's visits to the website, such as the number of visits, average time spent on the website and what pages have been loaded with the purpose of generating reports for optimising the website content. Expiry : 1 year Type : HTTP qcSes [x3] Collects data on the user's visits to the website, such as the number of visits, average time spent on the website and what pages have been loaded with the purpose of generating reports for optimising the website content. Expiry : Session Type : HTML Vimeo 1 Learn more about this provider vuid Collects data on the user's visits to the website, such as which pages have been read. Expiry : 399 days Type : HTTP Weborama 1 Learn more about this provider wui Contains an visitor ID. This is used to identify the visitor upon re-entry to the website. Expiry : 1 year Type : HTTP npgimages.com embed.smartframe.io 2 SF_TR_SESSION [x2] Registers if the user has visited or interacted with pages containing pictures or galleries rooting from third-party services. Used to improve website content and make statistical reports for the website. Expiry : Persistent Type : HTML Marketing 141 Marketing cookies are used to track visitors across websites. The intention is to display ads that are relevant and engaging for the individual user and thereby more valuable for publishers and third party advertisers. Meta Platforms, Inc. 3 Learn more about this provider _fbp [x3] Used by Facebook to deliver a series of advertisement products such as real time bidding from third party advertisers. Expiry : 3 months Type : HTTP Adobe 2 Learn more about this provider demdex Via a unique ID that is used for semantic content analysis, the user's navigation on the website is registered and linked to offline data from surveys and similar registrations to display targeted ads. Expiry : 179 days Type : HTTP dpm Sets a unique ID for the visitor, that allows third party advertisers to target the visitor with relevant advertisement. This pairing service is provided by third party advertisement hubs, which facilitates real-time bidding for advertisers. Expiry : 179 days Type : HTTP Appnexus 1 Learn more about this provider uuid2 Registers a unique ID that identifies a returning user's device. The ID is used for targeted ads. Expiry : 3 months Type : HTTP Bluekai.com 2 Learn more about this provider bkpa Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : 6 months Type : HTTP bku Registers anonymised user data, such as IP address, geographical location, visited websites, and what ads the user has clicked, with the purpose of optimising ad display based on the user's movement on websites that use the same ad network. Expiry : 6 months Type : HTTP Bombora 1 Learn more about this provider csync.ashx Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : Session Type : Pixel Dataxu 2 Learn more about this provider wfivefivec Collects data on the user's visits to the website, such as what pages have been loaded. The registered data is used for targeted ads. Expiry : 13 months Type : HTTP matchaddthis Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : 29 days Type : HTTP Fifty 3 Learn more about this provider fifid Registers the visitor's preferences and navigation across multiple social media platforms. This is used to present the visitor with relevant advertisement. Expiry : 1 year Type : HTTP fpst Collects statistical data related to the user's website visits, such as the number of visits, average time spent on the website and what pages have been loaded. The purpose is to segment the website's users according to factors such as demographics and geographical location, in order to enable media and marketing agencies to structure and understand their target groups to enable customised online advertising. Expiry : 6 days Type : HTTP cs Collects data on the user across websites - This data is used to make advertisement more relevant. Expiry : 1 year Type : HTTP Getsitecontrol 3 Learn more about this provider _gu Collects information on user preferences and/or interaction with web-campaign content - This is used on CRM-campaign-platform used by website owners for promoting events or products. Expiry : 1 year Type : HTTP _gs Collects information on user preferences and/or interaction with web-campaign content - This is used on CRM-campaign-platform used by website owners for promoting events or products. Expiry : Session Type : HTTP _gw Collects information on user preferences and/or interaction with web-campaign content - This is used on CRM-campaign-platform used by website owners for promoting events or products. Expiry : 1 year Type : HTTP Google 11 Learn more about this provider ads/ga-audiences Used by Google AdWords to re-engage visitors that are likely to convert to customers based on the visitor's online behaviour across websites. Expiry : Session Type : Pixel IDE Used by Google DoubleClick to register and report the website user's actions after viewing or clicking one of the advertiser's ads with the purpose of measuring the efficacy of an ad and to present targeted ads to the user. Expiry : 1 year Type : HTTP pagead/landing [x2] Collects data on visitor behaviour from multiple websites, in order to present more relevant advertisement - This also allows the website to limit the number of times that they are shown the same advertisement. Expiry : Session Type : Pixel pagead/viewthroughconversion/641272912 Pending Expiry : Session Type : Pixel pagead/1p-conversion/# Collects data on visitor behaviour from multiple websites, in order to present more relevant advertisement - This also allows the website to limit the number of times that they are shown the same advertisement. Expiry : Session Type : Pixel pagead/1p-user-list/# Tracks if the user has shown interest in specific products or events across multiple websites and detects how the user navigates between sites. This is used for measurement of advertisement efforts and facilitates payment of referral-fees between websites. Expiry : Session Type : Pixel _gcl_au [x3] Used by Google AdSense for experimenting with advertisement efficiency across websites using their services. Expiry : 3 months Type : HTTP NID Registers a unique ID that identifies a returning user's device. The ID is used for targeted ads. Expiry : 6 months Type : HTTP HybridTheory 2 Learn more about this provider ck Collects data on user visits to the website, such as what pages have been accessed. The registered data is used to categorise the user's interest and demographic profiles in terms of resales for targeted marketing. Expiry : 1 year Type : HTTP oo Collects data on user visits to the website, such as what pages have been accessed. The registered data is used to categorise the user's interest and demographic profiles in terms of resales for targeted marketing. Expiry : 1 year Type : HTTP ID5 5 Learn more about this provider cf Sets a unique ID for the visitor, that allows third party advertisers to target the visitor with relevant advertisement. This pairing service is provided by third party advertisement hubs, which facilitates real-time bidding for advertisers. Expiry : 1 day Type : HTTP car Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : 1 day Type : HTTP callback Collects data on visitor behaviour from multiple websites, in order to present more relevant advertisement - This also allows the website to limit the number of times that they are shown the same advertisement. Expiry : 1 day Type : HTTP cip Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : 1 day Type : HTTP cnac Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : 1 day Type : HTTP Issuu 1 Learn more about this provider iutk Recognises the user's device and what Issuu documents have been read. Expiry : 179 days Type : HTTP LiveRamp 2 Learn more about this provider pxrc This cookie registers data on the visitor. The information is used to optimize advertisement relevance. Expiry : 2 months Type : HTTP rlas3 Collects visitor data related to the user's visits to the website, such as the number of visits, average time spent on the website and what pages have been loaded, with the purpose of displaying targeted ads. Expiry : 1 year Type : HTTP Lotame 3 Learn more about this provider _cc_cc Collects statistical data related to the user's website visits, such as the number of visits, average time spent on the website and what pages have been loaded. The purpose is to segment the website's users according to factors such as demographics and geographical location, in order to enable media and marketing agencies to structure and understand their target groups to enable customised online advertising. Expiry : Session Type : HTTP _cc_dc Collects statistical data related to the user's website visits, such as the number of visits, average time spent on the website and what pages have been loaded. The purpose is to segment the website's users according to factors such as demographics and geographical location, in order to enable media and marketing agencies to structure and understand their target groups to enable customised online advertising. Expiry : 269 days Type : HTTP _cc_id Collects statistical data related to the user's website visits, such as the number of visits, average time spent on the website and what pages have been loaded. The purpose is to segment the website's users according to factors such as demographics and geographical location, in order to enable media and marketing agencies to structure and understand their target groups to enable customised online advertising. Expiry : 269 days Type : HTTP Meta Platforms, Inc. 1 Learn more about this provider fr Used by Facebook to deliver a series of advertisement products such as real time bidding from third party advertisers. Expiry : 3 months Type : HTTP Microsoft 20 Learn more about this provider MR Used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences. Expiry : 6 days Type : HTTP _uetvid [x3] Used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences. Expiry : Persistent Type : HTML _uetsid_exp [x3] Contains the expiry-date for the cookie with corresponding name. Expiry : Persistent Type : HTML _uetsid [x3] Collects data on visitor behaviour from multiple websites, in order to present more relevant advertisement - This also allows the website to limit the number of times that they are shown the same advertisement. Expiry : 1 day Type : HTTP _uetsid [x3] Used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences. Expiry : Persistent Type : HTML _uetvid [x3] Used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences. Expiry : 1 year Type : HTTP _uetvid_exp [x3] Contains the expiry-date for the cookie with corresponding name. Expiry : Persistent Type : HTML MUID Used widely by Microsoft as a unique user ID. The cookie enables user tracking by synchronising the ID across many Microsoft domains. Expiry : 1 year Type : HTTP National Portrait Gallery 1 Learn more about this provider ___utmvc Collects information on user behaviour on multiple websites. This information is used in order to optimize the relevance of advertisement on the website. Expiry : 1 day Type : HTTP Neustar 1 Learn more about this provider adscores/r.pixel Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : Session Type : Pixel Oath 6 Learn more about this provider IDSYNC Used to identify the visitor across visits and devices. This allows the website to present the visitor with relevant advertisement - The service is provided by third party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : 1 year Type : HTTP A3 Collects information on user behaviour on multiple websites. This information is used in order to optimize the relevance of advertisement on the website. Expiry : 1 year Type : HTTP B Collects anonymous data related to the user's website visits, such as the number of visits, average time spent on the website and what pages have been loaded. The registered data is used to categorise the users' interest and demographical profiles with the purpose of customising the website content depending on the visitor. Expiry : 1 year Type : HTTP A1S Pending Expiry : Session Type : HTTP GUC Registers a unique ID that identifies the user's device during return visits. Used for conversion tracking and to measure the efficacy of online ads. Expiry : 1 year Type : HTTP A1 Pending Expiry : 1 year Type : HTTP OnAudience 1 Learn more about this provider done_redirects# Pending Expiry : 1 day Type : HTTP Oracle 14 Learn more about this provider __atuvs Ensures that the updated counter is displayed to the user if a page is shared with the social sharing service, AddThis. Expiry : 1 day Type : HTTP _at.cww Used by the social sharing platform AddThis Expiry : Persistent Type : HTML uvc Detects how often the social sharing service, AddThis, encounters the same user. Expiry : 13 months Type : HTTP vc Used by the social sharing platform AddThis Expiry : 1 year Type : HTTP di2 Pending Expiry : 1 year Type : HTTP xtc Registers the user's sharing of content via social media. Expiry : 13 months Type : HTTP loc Geolocation, which is used to help providers determine how users who share information with each other are geographically located (state level). Expiry : 13 months Type : HTTP at-rand Used by the social sharing platform AddThis Expiry : Persistent Type : HTML mus Sets an ID-string for the specific visitor. This is used to recognize the visitor upon re-entry. This allows the website to register the visitor’s behaviour and facilitate the social media sharing function provided by Addthis.com. Expiry : 1 year Type : HTTP na_id Used to recognize the visitor upon re-entry. This allows the website to register the visitor’s behaviour and facilitate the social sharing function provided by Addthis.com. Expiry : 1 year Type : HTTP ouid Sets an ID-string for the specific visitor. This is used to recognize the visitor upon re-entry. This allows the website to register the visitor’s behaviour and facilitate the social media sharing function provided by Addthis.com. Expiry : 1 year Type : HTTP bt2 Used by the social sharing platform AddThis to keep a record of parts of the site that has been visited in order to recommend other parts of the site Expiry : 255 days Type : HTTP um Registers the user's sharing of content via social media. Expiry : 1 year Type : HTTP __atuvc Updates the counter of a website's social sharing features. Expiry : 13 months Type : HTTP Quantcast 1 Learn more about this provider mc Collects data on the user's visits to the website, such as what pages have been loaded. The registered data is used for targeted ads. Expiry : 13 months Type : HTTP Retargetly 2 Learn more about this provider sync Collects data on user behaviour and interaction in order to optimize the website and make advertisement on the website more relevant. Expiry : Session Type : Pixel _rlid Registers user behaviour and navigation on the website, and any interaction with active campaigns. This is used for optimizing advertisement and for efficient retargeting. Expiry : 180 days Type : HTTP Sharethis 9 Learn more about this provider int/lotame Facilitates the sharing function on the website. The cookie also allows websites to track and target the user with advertisement based on the user's likes and shares. Expiry : Session Type : Pixel mediamath Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : Session Type : Pixel st_samesite Used by ShareThis to track visitor’s website navigation and preferences - This is used for internal statistics and marketing. Expiry : Session Type : HTTP adobe Enables the visitor to share content from the website onto social media platforms or websites. Expiry : Session Type : Pixel yahoo Pending Expiry : Session Type : Pixel __stidv Used by ShareThis to track visitor’s website navigation and preferences - This is used for internal statistics and marketing. Expiry : 1 year Type : HTTP __stid Used by ShareThis to track visitor’s website navigation and preferences - This is used for internal statistics and marketing. Expiry : 1 year Type : HTTP pxcelPage_default_c010 Enables the visitor to share content from the website onto social media platforms or websites. Expiry : 6 days Type : HTTP pxcelBcnLcy Facilitates the sharing function on the website. The cookie also allows websites to track and target the user with advertisement based on the user's likes and shares. Expiry : Session Type : HTTP Shopify 7 Learn more about this provider _shopify_sa_t Collects data on visitors' behaviour and interaction - This is used to make advertisement on the website more relevant. The cookie also allows the website to detect any referrals from other websites. Expiry : 1 day Type : HTTP _shopify_sa_p Collects data on visitors' behaviour and interaction - This is used to make advertisement on the website more relevant. The cookie also allows the website to detect any referrals from other websites. Expiry : 1 day Type : HTTP shopify_recently_viewed Contains data on the content of the shopping cart. This data is used for marketing purposes by promoting related products or for retargeting purposes. Expiry : 3 months Type : HTTP _shopify_s [x2] Collects data on user behaviour and interaction in order to optimize the website and make advertisement on the website more relevant. Expiry : 1 day Type : HTTP _s [x2] Collects data on user behaviour and interaction in order to optimize the website and make advertisement on the website more relevant. Expiry : 1 day Type : HTTP Sitescout.com 2 Learn more about this provider ssi Registers a unique ID that identifies a returning user's device. The ID is used for targeted ads. Expiry : 1 year Type : HTTP _ssuma Presents the user with relevant content and advertisement. The service is provided by third-party advertisement hubs, which facilitate real-time bidding for advertisers. Expiry : 29 days Type : HTTP Soundcloud 1 Learn more about this provider WIDGET::local::assignments Used by audio-platform SoundCloud to implement, measure and improve their embedded content/service on the website - The collection of data also includes visitors’ interaction with embedded content/service. This can be used for statistics or marketing purposes. Expiry : Persistent Type : HTML Sovrn 2 Learn more about this provider _ljtrtb_# Collects data related to reader interests, context, demographics and other information on behalf of the Lijit platform with the purpose of finding interested users on websites with related content. Expiry : 1 year Type : HTTP ljt_reader Collects data related to reader interests, context, demographics and other information on behalf of the Lijit platform with the purpose of finding interested users on websites with related content. Expiry : 1 year Type : HTTP Spotify 2 Learn more about this provider sp_landing Used to implement audio-content from Spotify on the website. Can also be used to register user interaction and preferences in context with audio-content - This can serve statistics and marketing purposes. Expiry : 1 day Type : HTTP sp_t Used to implement audio-content from Spotify on the website. Can also be used to register user interaction and preferences in context with audio-content - This can serve statistics and marketing purposes. Expiry : 1 year Type : HTTP Tapad 4 Learn more about this provider TapAd_3WAY_SYNCS Used for data-synchronization with advertisement networks. Expiry : 2 months Type : HTTP TapAd_TS Used to determine what type of devices (smartphones, tablets, computers, TVs etc.) is used by a user. Expiry : 2 months Type : HTTP TapAd_DID Used to determine what type of devices (smartphones, tablets, computers, TVs etc.) is used by a user. Expiry : 2 months Type : HTTP idsync/ex/receive/check This cookie is set by the audience manager of the website to determine the time and frequencies of visitor data synchronization - cookie data synchronization is used to synchronize and gather visitor data from several websites. Expiry : Session Type : Pixel The Nielsen Company 2 Learn more about this provider ud Collects visitor data related to the user's visits to the website, such as the number of visits, average time spent on the website and what pages have been loaded, with the purpose of displaying targeted ads. Expiry : 119 days Type : HTTP EE Collects data related to the user's visits to the website, such as the number of visits, average time spent on the website and what pages have been loaded, with the purpose of displaying targeted ads. Expiry : 119 days Type : HTTP The Trade Desk 2 Learn more about this provider TDCPM Registers a unique ID that identifies a returning user's device. The ID is used for targeted ads. Expiry : 1 year Type : HTTP TDID Registers a unique ID that identifies a returning user's device. The ID is used for targeted ads. Expiry : 1 year Type : HTTP Tidal 2 Learn more about this provider sync-his Sets a unique ID for the visitor, that allows third party advertisers to target the visitor with relevant advertisement. This pairing service is provided by third party advertisement hubs, which facilitates real-time bidding for advertisers. Expiry : 1 year Type : HTTP tidal_ttid Registers the ads provided by Videology that the user has seen and/or clicked. Used to generate a demographic profile of the user. Expiry : 1 year Type : HTTP Twitter Inc. 1 Learn more about this provider guest_id Collects data related to the user's visits to the website, such as the number of visits, average time spent on the website and which pages have been loaded, with the purpose of personalising and improving the Twitter service. Expiry : 13 months Type : HTTP Weborama 1 Learn more about this provider AFFICHE_W Used by the advertising platform Weborama to determine the visitor's interests based on pages visits, content clicked and other actions on the website. Expiry : 1 year Type : HTTP YouTube 2 Learn more about this provider YSC Registers a unique ID to keep statistics of what videos from YouTube the user has seen. Expiry : Session Type : HTTP VISITOR_INFO1_LIVE Tries to estimate the users' bandwidth on pages with integrated YouTube videos. Expiry : 179 days Type : HTTP Zeotap 1 Learn more about this provider zc Registers data on visitors from multiple visits and on multiple websites. This information is used to measure the efficiency of advertisement on websites. Expiry : 1 year Type : HTTP addthis.com tag.crsspxl.com turn.com 3 uid [x3] Creates a unique, machine-generated user ID. AddThis, which is owned by Clearspring Technologies, uses the user ID to make it possible for the user to share content across social networks and provide detailed statistics to various providers. Expiry : 1 year Type : HTTP map.go.affec.tv ispot.tv 2 pt [x2] Collects data on user visits to the website, such as what pages have been accessed. The registered data is used to categorise the user's interest and demographic profiles in terms of resales for targeted marketing. Expiry : 1 year Type : HTTP npgshop.org.uk 2 _orig_referrer This cookie is used to collect information on a visitor. This information will become an ID string with information on a specific visitor – ID information strings can be used to target groups with similar preferences, or can be used by third-party domains or ad-exchanges. Expiry : Session Type : HTTP _landing_page Stores visitors' navigation by registering landing pages - This allows the website to present relevant products and/or measure their advertisement efficiency on other websites. Expiry : Session Type : HTTP sdks.shopifycdn.com npgshop.org.uk 4 _y [x2] Collects data on user behaviour and interaction in order to optimize the website and make advertisement on the website more relevant. Expiry : 399 days Type : HTTP _shopify_y [x2] Collects data on user behaviour and interaction in order to optimize the website and make advertisement on the website more relevant. Expiry : 399 days Type : HTTP speakeasy.forever.systems 1 speakeasy:uid Pending Expiry : Persistent Type : HTML tag.crsspxl.com pixel.mathtag.com 2 uuid [x2] This cookie is used to optimize ad relevance by collecting visitor data from multiple websites – this exchange of visitor data is normally provided by a third-party data-center or ad-exchange. Expiry : 2 months Type : HTTP v1.addthisedge.com 1 at-lojson-cache-# Used by the social sharing platform AddThis Expiry : Persistent Type : HTML Unclassified 15 Unclassified cookies are cookies that we are in the process of classifying, together with the providers of individual cookies. DirectedEdge 2 Learn more about this provider de_guid [x2] Pending Expiry : Session Type : HTTP Growave 6 Learn more about this provider hash_key Pending Expiry : 44 days Type : HTTP sswLoadsCntr Pending Expiry : Persistent Type : HTML ssw_visitor Pending Expiry : 1 day Type : HTTP igIcEvent Pending Expiry : Persistent Type : HTML debug_login Pending Expiry : Persistent Type : HTML hesid Pending Expiry : Session Type : HTTP npgshop.org.uk 5 gw_has_guest_wishlist_items Pending Expiry : Persistent Type : HTML _ssw_cart_data Pending Expiry : Persistent Type : HTML _ssw_cart_data Pending Expiry : 1 day Type : HTTP ssw-faves-lists Pending Expiry : Persistent Type : HTML /apps/ssw/lite2/feed/getFaves# Pending Expiry : Persistent Type : HTML tag.crsspxl.com 2 st_c Pending Expiry : 6 days Type : HTTP m.gif Pending Expiry : Session Type : Pixel Cross-domain consent 5 Your consent applies to the following domains: List of domains your consent applies to: competitions.npg.org.uk npgshop.org.uk npgimages.com npg.org.uk my.npg.org.uk Cookie declaration last updated on 5/20/2023 by Cookiebot [#IABV2_TITLE#] [#IABV2_BODY_INTRO#] [#IABV2_BODY_LEGITIMATE_INTEREST_INTRO#] [#IABV2_BODY_PREFERENCE_INTRO#] [#IABV2_LABEL_PURPOSES#] [#IABV2_BODY_PURPOSES_INTRO#] [#IABV2_BODY_PURPOSES#] [#IABV2_LABEL_FEATURES#] [#IABV2_BODY_FEATURES_INTRO#] [#IABV2_BODY_FEATURES#] [#IABV2_LABEL_PARTNERS#] [#IABV2_BODY_PARTNERS_INTRO#] [#IABV2_BODY_PARTNERS#] Cookies are small text files that can be used by websites to make a user's experience more efficient. 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Search Advanced Collection search About us Business and Hire Research Use this Image Licensing and copyright For all licensing and copyright matters [email protected] Florrie Forde (née Florence Flanagan) published by Ogden's bromide cigarette card, published circa 1897-1907 NPG x193103 © National Portrait Gallery, London Professional Licence What is this? Image licence and download for professional and commercial use . Images sizes are 2400 pixels wide at 300 dpi. What can I use the image for? Use in books, films, TV, merchandise, commercial and promotional activities, display and exhibition. How much does this cost? Costs depend on how and where you want to use the images. Register for an account and obtain a quotation. Academic Licence What is this? Image licence and download for academic and non-commercial use . Images sizes are 1500 pixels wide at 300 dpi. What can I use the image for? Use in your research paper, classroom or scholarly publication. 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High-temperature charge-density studies of CeO/sub 2-x/ using x-ray and neutron diffraction techniques (Conference) | OSTI.GOV The U.S. Department of Energy's Office of Scientific and Technical Information Title: High-temperature charge-density studies of CeO/sub 2-x/ using x-ray and neutron diffraction techniques Abstract High-resolution Bragg scattering experiments have been used to study the structure of polycrystalline CeO/sub 2-x/. The in-situ experiments were carried out as a function of temperature (300 < T < 1500/sup 0/K). The composition was controlled by flowing gases (CO/CO/sub 2/ or Ar/O/sub 2/ mixtures) over the sample. Results of both x-ray and neutron scattering experiments are used to define the principle atomic defects responsible for nonstoichiometry in CeO/sub 2-x/. Large lattice relaxation effects are observed whose magnitudes increase with increasing defect concentration. Temperature-dependent studies of the stoichiometric state (x = 0), show that lattice anharmonic interactions are important. The symmetry of the lattice anharmonic interactions is the same as the static displacements observed in the nonstoichiometric state. Thus, we propose that lattice anharmonic interactions are the fundamental driving force for the complex strain interactions observed in the nonstoichiometric state. 44 refs., 5 figs. Authors: Faber, J Jr Publication Date: 1987-07-01 Research Org.: Argonne National Lab., IL (USA) OSTI Identifier: 5848718 Report Number(s): CONF-870843-4 ON: DE88002988 DOE Contract Number: W-31109-ENG-38 Resource Type: Conference Resource Relation: Conference: International conference on electronic structure in phase stability in advanced ceramics, Argonne, IL, USA, 17 Aug 1987; Other Information: Portions of this document are illegible in microfiche products Country of Publication: United States Language: English Subject: 36 MATERIALS SCIENCE; CERIUM OXIDES; CRYSTAL DEFECTS; ANHARMONIC CRYSTALS; ATOMS; CHARGE DENSITY; CRYSTAL LATTICES; ELECTRONIC STRUCTURE; EQUATIONS; NEUTRON DIFFRACTION; POLYCRYSTALS; STRAINS; SYMMETRY; TEMPERATURE DEPENDENCE; CERIUM COMPOUNDS; CHALCOGENIDES; COHERENT SCATTERING; CRYSTAL STRUCTURE; CRYSTALS; DIFFRACTION; OXIDES; OXYGEN COMPOUNDS; RARE EARTH COMPOUNDS; SCATTERING; 360202* - Ceramics, Cermets, & Refractories- Structure & Phase Studies The general problem is the study, by x-ray means, of thermal vibrations of the atoms in crystals and their interactions with other phenomena of interest in crystal physics. The first experimental studies deal with the temperature dependences of the motions in AgCl as revealed by their effect on the Bragg intensities. Extended consideration was given in the background of the problem as found in the theory of and the literature on thermal motions of atoms, or lattice vibrations, as related in x-ray measurements of Bragg intensities. A method for determining temperature factors (hence Debye- THETA 's) from temperature dependences of more » x-ray intensities is derived and experimentally illustrated. A second method is suggested. Effects on the data of such things as thermal diffuse scattering (TDS), temperature dependence of primary extinction, and defect concentration are considered in some detail. Possibilities for assessing or studying the same factors through their effects on the apparent Bragg peaks are noted. Equipment design and performance, design of experiments, experimental techniques, and characteristics of the specimen, etc. are discussed in detail, especially in concention with accuracy and reproducibility. Particular attention has been given to means for shaping the specimens without distorting them. A conceptual device referred to as the acceptance region model was developed and utilized to determine the requirements on and the factors affecting the x-ray beam geometries. Intensity data were collected for (hhh), (hhO), and (hOO) reflections of AgCl at 10-degree intervals at 90 to 300 deg K. Variations in diffraction peak breadths with temperatures were observed and are discussed. Reproducibility in the intensity vs. temperature measurements was of about 0.5 to 0.75%. The amplitudes of thermal motions of the silver and chlorine atoms were found to be similar, and in agreement with observations by others. This result is interpreted in mean that the acoustic (rather than optical) modes of lattice vibrations have dominant importance to x-ray observations of the present type in AgCl. An inflection in the semi-log plot of intensity vs. temperature was found in the case of the (111) reflection. The possibility that the inflection may indicate a temperature induced change in bond character will be investigated. The errors introduced by TDS and alpha -doublet separation (both of which are temperature dependent) in the measures of Bragg intensities vs. temperature were partially overcome by a technique involving extrapolation to sin theta = 0. Evidence for anisotropy in the thermal motions of the atoms in AgCl was not conclusive, and further effort will be expended definitely to support or to reject present indications of anisotropy. Existence of anisotropy would probably indicate anharmonic thermal vibrations. Approximate Debye- THETA 's have been determined from the intensity vs. temperature data which are in reasonable agreement with literature values obtained by other means. The general technique of extracting crystal-physics information from careful measurements of the temperature dependence of the Bragg intensities continues to show promise. (auth) « less
https://www.osti.gov/biblio/5848718
Practice software start-up raises £100,000 | AccountingWEB Senta, the latest entrant into the already crowded practice management software game, is planning to take on the industry’s giants w iStock00063216911_Small Practice software start-up raises £100,000 Senta, the latest entrant into the already crowded practice management software game, is planning to take on the industry’s giants with a crowdfunding war chest of £100,000-plus. James Kilford’s start-up grew out of Webstart Bristol’s incubator programme based at The Engine Shed. It’s a busy space, filled with tech entrepreneurs beavering away at their tasks. With all the activity taking place around him, Kilford is soft spoken and calm. The creation ofSenta“was just by chance, really”, he says. His concept of a cloud-based practice management system evolved through a sequence of chance conversations. “I was working as a computer consultant. You get used to hearing people’s problems and then in your head trying to solve them,” Kilford says. “It was like that with Senta. I was talking to my accountant and he said, ‘I wish there was a system to help me with my practice, there’s some out there but they’re not very good’.” After speaking to his accountant, Kilford heard a similar story from other practitioners.  “I asked them ‘Are you using PM software? What are your big problems in practice?’ Most of them came back and said they weren’t even using practice management software,” he explains. Realising this was an opportunity, Kilford quit his contract, turned new client work and started looking for some office space, which led him to the Engine Shed. “Next thing I know, I’m down here talking to their panel and on their panel was an accountant, and he works as a partner for a really big local accounting firm. Everybody turned to him and asked ‘What do you think?’ “He said that he totally gets this and if I could solve all these problems, it would be great. So I joined the Engine Shed incubator program and Senta was born,” says Kilford. OnSenta’s Seedrs page, Kilford presents it as “a cloud service to help accountants run their practice really smoothly”. The service charges £29 a month and targets three specific areas: Workflow scheduling (the main focus), customer relationship management (CRM) and document security. There’s no niche, according to Kilford, merely an attempted solution to a universal problem within practice. Workflow scheduling is Senta’s biggest challenge. “An accountant might have to do 10,000-15,000 tasks in a year,” says Kilford. “They spend a lot of time managing their practice at a detriment to their professional and personal lives.” The CRM and marketing tools are lightweight and functional. They are meant for accountants to do simple tasks like keeping track of customer relationships, things like emails, he says. But practice management is not a new idea and Senta is a latecomer to the market. Senta’s competition includes industry giants Sage, IRIS and Keytime, along withmore recent arrivalsCapium and Nomisma. Kilford accepts this challenge in a zen-like way. “It’s difficult isn’t it?” he says, before giving his competition a gentle joust, “I realised that there was already a lot of competition out there, but they’re not doing something right because if they were everyone would be using it.” At the moment, flexibility is Senta’s biggest strength, as its relatively small size and freshness allows the developer to “introduce changes and fixes just about every day”. When a new user signs up to the service, Kilford writes to them personally, welcoming them: “Work with us, talk to us, tell us how it works or doesn’t work for you.” Being so open to suggestion and criticism can be tough, but Kilford’s philosophical about it, “When you can’t hear your customers grumbling anymore, then you’ve got a problem”. The £100,000-plus Seedrs fighting fund comes at just the right time for the company. Senta’s next big step is to integrate with the most popular cloud accounting suites. The money will also go toward new features and, as the reality of modern software necessitates, marketing. Financial necessities aside, crowdfunding also gels with Kilford’s business ideology. “If accountants want to buy a little slice of Senta, they can. Everyone can just get involved – ideologically it’s great. “We’ve got our 190-odd investors from this round, 147 investors from the previous round, who are on side. And a disproportionately high number of them are accountants." Kilford is very open about not being accountant. But he has been careful to surround himself with experienced practitioners. He has appointed an experienced accountant, Peter Chavis, as a non-executive CFO, and has an FD in place. It’s an unusual step for such a small company, but Kilford explains, “We wanted to have those disciplines in place and be able to call on their experience as we continue to grow.” As well as his in-house financial experience, Kilford leans heavily on his accountant. Since he first started the relationship has moved from focusing on compliance to a closer arrangement centring on advisory services. “Having an accountant who is willing to jump on the phone and jump on Skype to explain and talk about options is so important. It’s all about relationship.” Kilford is hopeful about Senta’s future. The strong backing on Seedrs indicates to him that he’s on the right track. “You could do your own practice management for nothing. You can use spreadsheets and diaries and of course, there’s much more expensive practice management software out there,” he says. “We just wanted something straight forward and affordable.” Alternative finance
https://www.accountingweb.co.uk/tech/practice-software/practice-software-start-up-raises-ps100000
The Effects of 8 oz Fresh vs. Commercial Orange Juice on Blood Pressure In Normotensive Males Aged 18-59 - Full Text View - ClinicalTrials.gov The Effects of 8 oz Fresh vs. Commercial Orange Juice on Blood Pressure In Normotensive Males Aged 18-59 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT03691194 Recruitment Status : Completed First Posted : October 1, 2018 Last Update Posted : July 18, 2019 Sponsor: Loma Linda University Information provided by (Responsible Party): Cory Gheen, Loma Linda University Study Details Study Description Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Brief Summary: The purpose of this graduate student research study is to determine the effects of drinking eight ounces of fresh vs. commercial orange juice on blood pressure in males with normal blood pressure. Condition or disease Intervention/treatment Phase Blood Pressure Dietary Supplement: fresh orange juice Dietary Supplement: concentrated orange juice Not Applicable Detailed Description: Visit 1 - Beginning of the first four weeks: Upon arrival, subjects will be given a consent form to sign. The student investigators will go over the layoutof the research study such as the procedures, and compliance with them. Then, subjects will be asked if they agree with drinking orange juice daily for two months. If they agree, they will be asked to relax for five minutes, and the student investigators will take their blood pressure reading three times using a blood pressure monitor. The subjects will complete the Perceived Stress Scale (PSS) survey before leaving. The subject will drink orange juice for 28 days. • Visits 2, 3, and 4: Subjects will meet with the student investigators at a convenient location. Subjects will be asked to rest for five minutes. Student investigators will then take their blood pressure reading three times using a blood pressure monitor. The subjects will complete the PSS survey before leaving. • Between visit 2 and 3: There is a washout period of approximately eight weeks. • During the first and second set of the 4 -week intervention phase, subjects will visit student investigators to retrieve orange juice samples every 3 or 4 days. Study Design Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Layout table for study information Study Type : Interventional  (Clinical Trial) Actual Enrollment : 17 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: Single (Participant) Primary Purpose: Other Official Title: The Effects of 8 oz Fresh vs. Commercial Orange Juice on Blood Pressure In Normotensive Males Aged 18-59 Actual Study Start Date : October 1, 2018 Actual Primary Completion Date : June 1, 2019 Actual Study Completion Date : June 1, 2019 Arms and Interventions Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Arm Intervention/treatment Experimental: fresh orange juice Subject will take 8 ounces of fresh orange every day for 28 days. Dietary Supplement: fresh orange juice The fresh oranges will be bought from Sysco. They will be squeezed at the kitchen of School of Allied Health Professional with a juicer. They will either be squeezed the night before or on the same day. The juice will not be treated with additional preservatives or sugar. The brand of the juicer is Kitchen Aid. Eight ounces of fresh orange juice needs approximately two and half oranges. They will be put into 32 oz water bottles that were bought from Sysco, and then store them in the refrigerator. They will be given to the subjects every three or four days. Active Comparator: concentrated orange juice Subject will take 8 ounces of concentrated orange juice every day for 28 days. Dietary Supplement: concentrated orange juice The concentrated orange juice will be bought from Sysco then reconstituted. One part of concentrated orange juice needs four parts of water to reconstitute. Then, it will be measured and the reconstituted orange juice will be put into 32 oz water bottles that we bought from Sysco. They will be stored in the refrigerator. The subjects will need to get the reconstituted orange juice every three or four days. Outcome Measures Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Primary Outcome Measures : blood pressure [ Time Frame: change from baseline to 4 weeks ] Three readings will be taken each time and average them. If the subject's blood pressure is considered too high or low at any of the visits, they will be dropped from the study and we will suggest to them to see their primary physician. Secondary Outcome Measures : Perceived Stress Scale (PSS) [ Time Frame: change from baseline to 4 weeks ] The PSS was developed by Sheldon Cohen and his colleagues, and was published in 1983. The PSS is a widely used psychological instrument to measures the level of stress. It has been used in many studies related to stress. The survey takes approximately three minutes to complete. The score ranges from 0-40. A score of 0-13 is considered low stress, 14-26 is moderate stress, and 27-40 is high stress. Eligibility Criteria Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Layout table for eligibility information Ages Eligible for Study: 18 Years to 59 Years   (Adult) Sexes Eligible for Study: Male Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Healthy 18-59 years old males, willing to keep the same lifestyle, not taking any medications or antioxidant supplements to control blood pressure, and do not drink any types of orange juice within 30 days. Exclusion Criteria: Diabetic, smoke cigarettes, marijuana or electronic cigarettes, drink alcohol more than one a week, allergic to oranges, and diagnosed as hypotensive or hypertensive. Contacts and Locations Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03691194 Locations Layout table for location information United States, California Loma Linda Universtiy Loma Linda, California, United States, 92350 Loma Linda University Investigators Layout table for investigator information Principal Investigator: Cory Gheen, MS RD Loma Linda University Layout table for additonal information Responsible Party: Cory Gheen, Assistant Professor, Loma Linda University ClinicalTrials.gov Identifier: NCT03691194 History of Changes Other Study ID Numbers: 5180291 First Posted: October 1, 2018 Key Record Dates Last Update Posted: July 18, 2019 Last Verified: July 2019 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No U.S. Department of Health and Human Services
https://clinicaltrials.gov/ct2/show/NCT03691194
Identifying “Preperimetric” Glaucoma in Standard Automated Perimetry Visual Fields | IOVS | ARVO Journals December 2014 Volume 55, Issue 12 Ryo Asaoka ; Aiko Iwase ; Kazunori Hirasawa ; Hiroshi Murata ; Makoto Araie Author Affiliations & Notes Ryo Asaoka Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan Aiko Iwase Tajimi Iwase Eye Clinic, Tajimi, Japan Kazunori Hirasawa Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan Department of Ophthalmology, Graduate School of Medical Science, Kitasato University, Kanagawa, Japan Hiroshi Murata Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan Makoto Araie Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan Correspondence: Ryo Asaoka, Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan; [email protected] . Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7814-7820. doi: https://doi.org/10.1167/iovs.14-15120 Abstract Purpose.: To compare the visual fields (VFs) of preperimetric open angle glaucoma (OAG) patients (preperimetric glaucoma VFs, PPGVFs) with the VFs of healthy eyes, and to discriminate these two groups by using the Random Forests machine-learning method. Methods.: All VFs before a first diagnosis of manifest glaucoma (Anderson-Patella's criteria) were classified as PPGVFs. Series of VFs were obtained with the Humphrey Field Analyzer 30-2 program from 171 PPGVFs from 53 eyes in 51 OAG or OAG suspect patients and 108 healthy eyes of 87 normal subjects. The area under the receiver operating characteristic curve (AROC) in discriminating between PPGVFs and healthy VFs was calculated by using the Random Forests method, with 52 total deviation (TD) values, mean deviation (MD), and pattern standard deviation (PSD) as predictors. Results.: There was a significant difference in MD between healthy VFs and PPGVFs (−0.03 ± 1.11 and −0.91 ± 1.56 dB [mean ± standard deviation], respectively; P < 0.001, linear mixed model) and in PSD (1.56 ± 0.33 and 1.97 ± 0.43 dB, respectively; P < 0.001). A significant difference was observed in the TD values between healthy VFs and PPGVFs at 25 ( P < 0.001) of 52 test points (linear mixed model). The AROC obtained by using the Random Forests method was 79.0% (95% confidence interval, 73.5%–84.5%). Conclusions.: Differences exist between healthy VFs and VFs of preperimetric glaucoma eyes, which go on to develop manifest glaucoma; these two groups of VFs could be well distinguished by using the Random Forests classifier. Introduction Prompt diagnosis of glaucoma is critical to reduce the risk of visual impairment, as glaucomatous visual field (VF) damage is irreparable. There is evidence that glaucomatous axonal loss precedes the development of VF defects. 1 In fact, it is now possible to detect early glaucomatous structural changes before the deterioration of patients' VFs becomes measurable, owing to the development of imaging devices, such as optical coherence tomography 2 – 8 and scanning laser polarimetry. 8 , 9 Furthermore, several studies have suggested that some forms of perimetry, such as frequency-doubling perimetry (FDT), 10 – 16 Humphrey Matrix 24-2 test, 17 short-wavelength automated perimetry (SWAP), 10 , 16 , 18 – 20 and Heidelberg edge perimetry 21 may detect glaucomatous VF changes earlier than conventional standard automated perimetry (SAP). In clinical practice, we often encounter eyes with structural changes suggestive of glaucoma, but with apparently normal VF test results. The term “preperimetric glaucoma” (PPG) has been used to describe eyes with a glaucomatous optic disc and/or fundus appearance and an apparently normal VF. Several methods, such as abnormal result from the glaucoma hemifield test (GHT) or a significant pattern standard deviation (PSD) value, 16 are used to define glaucomatous VFs 4 – 11 , 16 , 17 but Anderson-Patella's criteria 22 remain one of the most frequently applied methods. 4 , 6 , 10 , 11 , 17 Briefly, the criteria are as follows: (1) a cluster of ≥3 points in the pattern deviation plot in a single hemifield (superior/inferior) with P < 0.05, one of which must have been P < 0.01, excluding the outermost test point of Humphrey Field Analyzer 30-2 program (HFA 30-2); (2) GHT result outside of normal limits; or (3) abnormal PSD with P < 0.05. Thus, the criteria are designed to be sensitive to focal VF deterioration as well as global VF changes, which is advantageous to detect early glaucomatous VF damage. 23 – 25 Preperimetric glaucoma VFs (PPGVFs) can be defined as VFs taken before diagnosis of manifest glaucoma by Anderson-Patella's criteria. 22 In this study, a machine-learning classifier known as the Random Forests method was applied to differentiate PPGVFs from healthy VFs. 26 , 27 In short, the Random Forests consists of many decision trees (each tree developed by bootstrapping of data and predictor variables) and outputs a classification based on all the decision trees. This algorithm has been used in many research fields, such as gene selection and cancer classification, 28 – 31 and it has been suggested that the Random Forests method is more useful than other machine-learning methods. 28 , 32 , 33 Furthermore, its potential for diagnosing glaucoma has been reported. 2 , 34 The merit of using this method is that it can cope with intercorrelation of multiple explanatory variables, 35 which makes it especially useful in analyzing VF test results where intercorrelation of VF sensitivities among test points is well known. Additionally, the Random Forests method interprets multiple explanatory variables in combination, deciphering important patterns, 36 which may be advantageous in trying to detect early glaucomatous VF changes that have not yet fulfilled Anderson-Patella's criteria. 22 Methods Subjects Preperimetric glaucoma VFs were retrospectively acquired from clinical records at the University of Tokyo Hospital (Tokyo, Japan). First, all open angle glaucoma (OAG) or OAG suspect patients who had VF measurements at least 15 times between April 1997 and April 2012 were identified. Open angle glaucoma was diagnosed when the following findings were present: (1) presence of typical glaucomatous changes in the optic nerve head (ONH), such as a rim notch with a rim width ≤ 0.1 disc diameters or a vertical cup-to-disc ratio of >0.7, and/or a retinal nerve fiber layer (RNFL) defect with its edge at the ONH margin greater than a major retinal vessel, diverging in an arcuate or wedge shape confirmed by a panel of glaucoma specialists (HM and RA) after inspection of stereo-fundus photographs; (2) presence of glaucomatous VF defects compatible with the glaucomatous ONH changes fulfilling Anderson-Patella's criteria 22 on two consecutive occasions; and (3) absence of other systemic or ocular disorders, including cataract except for clinically insignificant senile cataract, shallow peripheral anterior chamber that could affect the ONH and VF, and history of intraocular surgeries or refractive surgeries except for uneventful intraocular lens implantation. Patients aged 20 years or older and eyes with refractive error ≥ −6.0 D and <6.0 D, and also visual acuity equal to or better than 30/30 were included. As a result, VFs from 790 eyes of 589 OAG or OAG suspect patients were identified. After the first VF of each eye was excluded, 37 , 38 PPGVFs were identified as all VFs before the first VF meeting with at least one of Anderson-Patella's criteria (without a need to be confirmed in the consecutive VF test). 22 As a result, 171 PPGVFs from 53 eyes of 51 patients were used in the analysis. Data from 108 normal eyes of 87 subjects were acquired at the University of Tokyo Hospital, the Tajimi Municipal Hospital (Gifu, Japan), and Tajimi Iwase Eye Clinic (Gifu, Japan) between April 1997 and October 2006. Inclusion criteria included no abnormal eye-related findings except for clinically insignificant senile cataract on biomicroscopy, gonioscopy, and funduscopy, and no history of ocular diseases, such as diabetic retinopathy or age-related macular degeneration; other inclusion criteria were age ≥ 20 years, spherical equivalent refractive error ≥ −6.0 D and <6.0 D, intraocular pressure ≤ 21 mm Hg by Goldmann applanation tonometry, having undergone HFA measurement at least one time, and normal VF test results that did not meet any of Anderson-Patella's criteria and no family history of glaucoma. 22 The study protocol was approved by the institutional review board of each institution and adhered to the tenets of the Declaration of Helsinki. Written informed consent was obtained from each subject. Visual Field Measurements All VFs were obtained by using the Humphrey Field Analyzer (HFA; Carl Zeiss Meditec, Dublin, CA, USA) with the 30-2 SITA Standard strategy (HFA 30-2) and the Goldmann size III target. Near refractive correction was used as necessary. Reliable VFs were defined as results with less than 20% fixation losses and less than 15% false-positive error, following the criteria used by the HFA software. Statistical Analyses The Random Forests method was used to classify VFs as PPGVFs or healthy VFs, by using the 52 TD values that correspond to the HFA 24-2 program test points, MD, and PSD as predictors; thus, TD values of the outermost 22 test points in the 30-2 test pattern were excluded. In the Random Forests method, 10,000 decision trees were grown to build an “ensemble classifier.” The leave-one-out cross-validation method was then performed and the area under the receiver operating characteristic curve (AROC) was calculated by changing the cutoff value for the probability of a VF being classified as a PPGVF (as indicated by the proportion of tree votes in the Random Forests classifier). 39 In leave-one-out cross-validation, one or both eyes of a single subject were used as validation data, and the remaining subjects were used as training data. This procedure was then repeated until each OAG patient and healthy subject in the original sample was used once as validation data. In other words, for each individual, only the data from all other subjects was used in the prediction. All statistical analyses were carried out by using the statistical programming language R (version 2.15.1; The R Foundation for Statistical Computing, Vienna, Austria). The R package “randomForest” was used to generate the Random Forests classifier. The importance VF parameters used in the Random Forests method was determined by using the Random Forests “Variable Importance” (VIMP) measure; this was calculated by randomly permuting a variable at each decision tree and measuring whether the squared errors decreased. 26 The optimum cutoff point in the receiver operating characteristic curve was calculated by using Youden's method. 40 The difference between the two groups was investigated by using a linear mixed-effects model 41 when two or more measurement results in the same eye and same subject were included, with the R package “lme4”; this model inherently accounts for imbalances in the numbers of VFs per eye and of a subject. Results Demographic data of the subjects are given in the Table . The mean interval between patients' last PPGVF to the time of conversion to the first glaucomatous VF (i.e., Anderson-Patella's criteria 22 met on two consecutive occasions) averaged 315.8 ± 184.3 (standard deviation, SD) days. The average interval between consecutive PPGVFs (i.e., until Anderson-Patella's criteria were met at any occasion without the need of being repeated in the consecutive VF) was 271.1 ± 188.1 days. There were no intergroup differences in right eye/left eye, male/female ratios ( P = 0.78 and 0.35, respectively, χ 2 test), and in refractive error ( P = 0.21, unpaired t -test), except for age ( P = 0.008). The average number of PPGVFs per eye was 3.2 ± 2.0 (mean ± SD). Table Characteristics of the Study Participants Table Characteristics of the Study Participants Normal Group Glaucoma Group P Value Sex, male/female 35/52 26/25 0.09 Eye, right/left 51/57 27/26 0.78 Age, mean ± SD, y 50 ± 16 55 ± 15 0.008 Refractive error, diopter, mean ± SD −0.15 ± 1.1 −0.55 ± 0.33 0.21 P value: comparison between glaucoma and normal groups (unpaired t -test for numerical data and χ 2 test for categorical data). Figures 1 a and 1 b show the mean TD value at each location across all healthy VFs and all PPGVFs, respectively. A significant difference was observed in TD values between healthy VFs ( Fig. 1 a) and PPGVFs ( Fig. 1 b) at 25 of 52 test locations with a significance level of P < 0.001 (linear mixed model); none of the mean TD values in the healthy VFs were lower than −1.0 dB, whereas in the PPGVFs 22 of 52 test points were lower than this threshold. There was a significant intergroup difference in the MDs (−0.03 ± 1.11 and −0.91 ± 1.56 dB in healthy VFs and in PPGVFs, respectively; P < 0.001, linear mixed model) and PSDs (1.56 ± 0.33 and 1.97 ± 0.43 dB, respectively; P < 0.001; Figs. 2 a, 2 b). Only 2.8% (3 VFs) of the healthy VFs, as compared with 12.3% (21 VFs) of PPGVFs, had a PSD above +2.5 dB. Pattern standard deviation was above +2.0 dB in 10.2% (11 VFs) of the healthy VFs and 39.2% (67 VFs) of PPGVFs. None of the healthy VFs with a PSD above +2.0 dB had GHT results “outside normal limits”; moreover, the deterioration of VF thresholds appeared simply to be measurement noise. Glaucoma hemifield test results were “borderline” in 16.7% (18) of healthy VFs and in 8.2% (14) of PPGVFs. There was a “general reduction of sensitivity” in GHT result in two PPGVFs (1.1%). Two (1.9%) healthy VFs and 10 (5.8%) PPGVFs had a PSD with a P value between 0.05 and 0.10. Figure 1 Mean and standard deviation of the total deviation values of healthy and preperimetric glaucoma visual fields (PPGVFs). The number in brackets below the mean value represents the standard deviation. ( a ) Normal eyes. ( b ) Preperimetric glaucoma eyes. *Significant difference between the healthy and PPGVFs with the significance level of P < 0.001 (written in red ; linear mixed-effects model). TD values in the 22 outermost test points (gray) were excluded from analysis. Figure 1 Figure 2 Boxplots comparing mean deviation and pattern standard deviation values in healthy visual fields and preperimetric glaucoma visual fields (PPGVFs). ( a ) Mean deviation. ( b ) Pattern standard deviation. P values were calculated by using the linear mixed model. Figure 2 Boxplots comparing mean deviation and pattern standard deviation values in healthy visual fields and preperimetric glaucoma visual fields (PPGVFs). ( a ) Mean deviation. ( b ) Pattern standard deviation. P values were calculated by using the linear mixed model. As shown in Figure 3 , the AROC obtained by using the Random Forests method was 79.0% (confidence interval [CI], 73.5%–84.5%). Sensitivities at specificities of 80%, 90%, and 95% were 59.6%, 40.4%, and 25.1%, respectively. The optimum discrimination, using Youden's method, 40 was obtained when sensitivity was equal to 86.5% and specificity was equal to 62.0%; this corresponded to a voting rate of ≻53.8% in the Random Forests classifier. The 15 most important parameters (according to VIMP score) in the Random Forest system are depicted in Figure 4 . Figure 3 Receiver operating characteristic curves obtained with the Random Forests method. The AROC with the Random Forests method was 79.0% (CI: 73.5%–84.5%). The optimal cut point was at a voting rate equal to 53.8% where the sensitivity was 86.5% and specificity was 62.0%, using Youden's method. 40 Figure 3 Receiver operating characteristic curves obtained with the Random Forests method. The AROC with the Random Forests method was 79.0% (CI: 73.5%–84.5%). The optimal cut point was at a voting rate equal to 53.8% where the sensitivity was 86.5% and specificity was 62.0%, using Youden's method. 40 Figure 4 The 15 most important parameters in the Random Forests diagnosing system. Left figure represents the VF test points numbers. The outermost test points were not used. The right figure shows the 15 most important visual field parameters, which were decided by calculating the total decrease in node impurities by permuting each variable in each tree and observing the decrease of the Gini index, followed by normalizing by the standard deviation of the difference. The 15 most important parameters in the Random Forests diagnosing system. Left figure represents the VF test points numbers. The outermost test points were not used. The right figure shows the 15 most important visual field parameters, which were decided by calculating the total decrease in node impurities by permuting each variable in each tree and observing the decrease of the Gini index, followed by normalizing by the standard deviation of the difference. Discussion In the current study, series of VFs of OAG patients were examined and the properties of VFs before an eye's conversion to glaucomatous VF, following Anderson-Patella's criteria, 22 were investigated by using the Random Forests classifier. Significant deterioration of TD values was observed at 25 ( P < 0.001) of 52 test points in the PPGVFs; in addition, a significant difference in MD and PSD was also observed between PPGVFs and healthy VFs. Furthermore, a sizeable number of PPGVFs could be discriminated from healthy VFs by using the Random Forests machine-learning classifier. Previous attempts have been made to discriminate PPG from healthy eyes by using various devices and special forms of perimetry, in a cross-sectional manner. Choi et al. 17 have used MD and PSD of the Humphrey Matrix 24-2 test and obtained an AROC of 61.9% and 76.7% for each index, respectively; in their study PPG was diagnosed by using a combination of red-free fundus photography, Stratus optical coherence tomography (OCT), and stereophotography. 17 Leeprechanon et al. 16 have used FDT and SWAP and reported AROCs of 62% (FDT MD), 67% (FDT PSD), 74% (SWAP MD), and 53% (SWAP MD), in which PPG was defined by abnormal findings with either OCT or Heidelberg retina tomograph (HRT). In a study by Hirashima et al., 11 FDT is used to discriminate PPG defined as abnormal on stereophotography, and AROCs of 76.2% (MD) and 78.0% (PSD) are reported. In addition, similar efforts have been made with imaging devices; the reported AROCs are 79% to 94% with OCT 4 – 7 , 11 in which the diagnosis of PPG is made by using stereophotography 5 , 7 , 11 and/or red-free photography, 4 , 6 and 91% with SLP in which red-free photography, SLP, or OCT is used to diagnose PPG. 8 The 95% CI of the AROC obtained in the current study (73.5%–84.5%) overlaps with those reported by FDT or SWAP and some of those reported with imaging devices; however, it is not appropriate to directly compare AROCs because of considerable differences in the study designs. In the current study, PPGVFs were categorized as the VFs undertaken before conversion to a glaucomatous VF according to Anderson-Patella's criteria; PPGVFs were then discriminated from healthy normal VFs. On the other hand, PPG eyes, not PPGVFs, are distinguished from healthy normal eyes in the previous studies. In addition, the definition of PPG is not always the same across these studies, as detailed above. Moreover, the criteria for classifying glaucomatous VFs also vary. For instance, all conditions included in Anderson-Patella's criteria are used in the studies of Hirashima et al. 11 and Choi et al., 17 while an abnormal result with GHT or PSD is used in the study by Leeprechanon et al. 16 In the current study, an abnormal VF result was defined as meeting at least one of the three conditions included in Anderson-Patella's criteria. 22 There are only two studies that have analyzed the usefulness of OCT and HRT in diagnosing PPG with longitudinal series of VFs. 5 , 7 In these studies, patients suspected of having glaucoma, based on the appearance of the optic disc on stereophotography, have been followed up longer than 10 years (VF remained normal throughout the follow-up); it was investigated whether HRT and OCT can discriminate between PPG eyes with stereophotographic evidence of progressive glaucomatous change and those without stereophotographic evidence of progressive glaucomatous change. As a result, the largest AROC is obtained with OCT temporal superior RNFL thickness (88%), followed by OCT global RNFL thickness (86%) and HRT rim area (72%) 7 and average RNFL thickness (89%), followed by inferior hemisphere average RNFL thickness (87%) and inferior quadrant average RNFL thickness (85%). 5 The focus of the current study was to discriminate PPGVFs, defined as normal according to Anderson-Patella's criteria, from VFs taken in healthy eyes. The PPGVFs were all taken from preperimetric OAG eyes that later went on to develop manifest glaucoma. Importantly, this study is unique, since any extra functional and/or structural measurements were not included; instead only SAP VFs were included. The Random Forests method was able to discriminate between PPGVFs and VFs from healthy eyes at least as well as FDT or SWAP can discriminate PPG eyes from normal eyes. This suggests that many PPGVFs have a retinal sensitivity distribution different from that observed in healthy eyes. Pattern deviation (PD), TD values, MD, and PSD are displayed in VF test results alongside their associated significance levels; these are calculated by comparing the observed results against a normative database. Consequently, the diagnosis of glaucoma, based only on SAP measurements' significance levels, is difficult in early glaucoma where there may be considerable overlap between the range of sensitivity values of normal eyes and early glaucomatous eyes. 42 This phenomenon may be especially apparent with SAP in which all types of ganglion cells are stimulated. 43 Anderson-Patella's criteria 22 adopt PD values, instead of TD results, to diagnose glaucoma, since it is believed that these values help to eliminate the effects of cataract on the measured retinal sensitivity. 44 Since eyes with cataract were excluded from both groups in the current study, using PD values in the Random Forests classifier instead of TD values is unlikely to offer any improvement; indeed, the use of PDs instead of TDs did not improve the AROC associated with the Random Forest method to discriminate PPGVFs and healthy VFs (AROC: 77.0% [CI: 70.9%–83.1%]). We have shown that the Random Forests classifier can distinguish a considerable proportion of PPGVFs from healthy VFs (sensitivity was equal to 59.6%, 40.4%, and 25.1% at specificity of 80%, 90%, and 95%, respectively). This level of discrimination could possibly be increased if SAP testing procedures were modified. For example, the 30-2 test grid of the HFA has test points located in 6-degree intervals, which is not ideal for detecting 45 and evaluating 46 – 48 glaucomatous VF change because small, localized VF changes may be missed; instead, only less apparent deteriorated sensitivity is shown on VF, if these occur in between test points. Indeed, recent research has shown that adoption of a HFA 10-2 test program reveals glaucomatous VF defects in 16% of eyes whose HFA 24-2 test results are normal. 49 Interestingly, 12.3% of PPGVFs had a PSD value above +2.5 dB, whereas only 2.8% of the healthy VFs had a PSD above that value. There was a significant difference in the TD values in 25 ( P < 0.001) of 52 VF test points; however, the contribution of these test points to the discrimination was much less than that of PSD ( Fig. 4 ). This is probably because the VF area primarily affected in glaucoma varies among patients and no one test point can serve as a universal landmark of glaucomatous VF deterioration. However, TD values in the superior nasal step and arcuate area close to the blind spot showed relatively strong contributions to the discrimination ( Fig. 4 ), being compatible with the importance of Bjerrum and superior nasal step area as initial sites of glaucomatous damage. On the other hand, deterioration of PSD, representing un-uniformity of the damage at each test point, should be independent of the location of the initial VF deterioration. Thus, clinicians should be advised to treat patients carefully when PSD is above 2.5 dB, even if it is not deemed significant deterioration (i.e., P < 0.05). Agreeing with this result, the Ocular Hypertension Treatment Study has reported that PSD at baseline is the only VF parameter that significantly contributes to the future development of primary OAG. 50 All of the analyses in the current study were carried out by using existing statistical software, specifically the language “R” which is an open source statistical program. In the current study, the leave-one-out cross-validation with the Random Forests method was performed, in which the original data set was split into validating (one subject) and training (all of other subjects) data sets, being repeated for the number of subjects in the original data set so that all of the subjects were used as validating data once. This is equivalent to predicting the diagnosis of a new patient (validating data set) by using the Random Forests diagnosis system trained by using the previous training data set in clinics. Thus, a Random Forests clinical support tool could be built simply on a personal computer; clinicians would then be able to diagnose a new patient's VF with the sensitivity and specificity shown in Figure 3 . In the current study, only normal VFs from healthy eyes were included (abnormal VFs from healthy eyes were excluded from analyses), as the purpose of this study was to compare normal VFs against PPGVFs; however, in clinical settings, a substantial number of abnormal VFs are observed owing to high variability, but also as a result of various disorders, such as systemic disorders. Thus, a limitation of the current study is that the results cannot be directly applied to discriminate between normal and nonglaucomatous abnormal VFs. A limitation of the current study is that the average age of the PPG group was significantly greater than that of the healthy group. This may have an influence on the PSD value; however, any impact is likely to be minimal because it is already corrected for age; indeed, we did not observe a significant relationship between age and PSD in the current population ( P = 0.90, data not shown). A further limitation of the present study concerns the lack of external validation. Unfortunately, as far as we know, no previous studies have investigated PPGVFs longitudinally, but instead have collected PPGVFs in a cross-sectional manner with no confirmation that they convert to glaucomatous VFs. Thus, we have used leave-one-out cross-validation whereby, for each individual, only the data from other subjects were used in the model's prediction. Thus, there is no overlap between the “training” and “validation” data sets. Nonetheless, it would be desirable to carry out a further study to validate the current results by using an external, independent data set. 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Invest Ophthalmol Vis Sci . 2014; 55: 2584–2591. [PubMed] 49. Traynis I De Moraes CG Raza AS Prevalence and nature of early glaucomatous defects in the central 10 degrees of the visual field. JAMA Ophthalmol . 2014; 132: 291–297. [CrossRef] [PubMed] 50. Ocular Hypertension Treatment Study Group and the European Glaucoma Prevention Study Group. The accuracy and clinical application of predictive models for primary open-angle glaucoma in ocular hypertensive individuals. Ophthalmology . 2008; 115: 2030–2036. [CrossRef] [PubMed] Figure 1 Mean and standard deviation of the total deviation values of healthy and preperimetric glaucoma visual fields (PPGVFs). The number in brackets below the mean value represents the standard deviation. ( a ) Normal eyes. ( b ) Preperimetric glaucoma eyes. *Significant difference between the healthy and PPGVFs with the significance level of P < 0.001 (written in red ; linear mixed-effects model). TD values in the 22 outermost test points (gray) were excluded from analysis. Figure 1 Mean and standard deviation of the total deviation values of healthy and preperimetric glaucoma visual fields (PPGVFs). The number in brackets below the mean value represents the standard deviation. ( a ) Normal eyes. ( b ) Preperimetric glaucoma eyes. *Significant difference between the healthy and PPGVFs with the significance level of P < 0.001 (written in red ; linear mixed-effects model). TD values in the 22 outermost test points (gray) were excluded from analysis. Figure 2 Boxplots comparing mean deviation and pattern standard deviation values in healthy visual fields and preperimetric glaucoma visual fields (PPGVFs). ( a ) Mean deviation. ( b ) Pattern standard deviation. P values were calculated by using the linear mixed model. Figure 2 Boxplots comparing mean deviation and pattern standard deviation values in healthy visual fields and preperimetric glaucoma visual fields (PPGVFs). ( a ) Mean deviation. ( b ) Pattern standard deviation. P values were calculated by using the linear mixed model. Figure 3 Receiver operating characteristic curves obtained with the Random Forests method. The AROC with the Random Forests method was 79.0% (CI: 73.5%–84.5%). The optimal cut point was at a voting rate equal to 53.8% where the sensitivity was 86.5% and specificity was 62.0%, using Youden's method. 40 Figure 3 Receiver operating characteristic curves obtained with the Random Forests method. The AROC with the Random Forests method was 79.0% (CI: 73.5%–84.5%). The optimal cut point was at a voting rate equal to 53.8% where the sensitivity was 86.5% and specificity was 62.0%, using Youden's method. 40 Figure 4 The 15 most important parameters in the Random Forests diagnosing system. Left figure represents the VF test points numbers. The outermost test points were not used. The right figure shows the 15 most important visual field parameters, which were decided by calculating the total decrease in node impurities by permuting each variable in each tree and observing the decrease of the Gini index, followed by normalizing by the standard deviation of the difference. Figure 4 The 15 most important parameters in the Random Forests diagnosing system. Left figure represents the VF test points numbers. The outermost test points were not used. The right figure shows the 15 most important visual field parameters, which were decided by calculating the total decrease in node impurities by permuting each variable in each tree and observing the decrease of the Gini index, followed by normalizing by the standard deviation of the difference. Table Characteristics of the Study Participants Table Characteristics of the Study Participants Normal Group Glaucoma Group P Value Sex, male/female 35/52 26/25 0.09 Eye, right/left 51/57 27/26 0.78 Age, mean ± SD, y 50 ± 16 55 ± 15 0.008 Refractive error, diopter, mean ± SD −0.15 ± 1.1 −0.55 ± 0.33 0.21 P value: comparison between glaucoma and normal groups (unpaired t -test for numerical data and χ 2 test for categorical data).
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06/06/84 DENNIS SHERROD v. UNITED STATES | District of Columbia Court of Appeals | 06-06-1984 | www.anylaw.com Research the case of 06/06/84 DENNIS SHERROD v. UNITED STATES, from the District of Columbia Court of Appeals, 06-06-1984. AnyLaw is the FREE and Friendly legal research service that gives you unlimited access to massive amounts of valuable legal data. This case cites: This case is cited by: 06/06/84 DENNIS SHERROD v. UNITED STATES ROGERS, Associate Judge: Appellant was convicted by a jury of murder in the first degree while armed (D.C. Code §§ 22-2401, -3202 (1981)) and assault with intent to kill (id. §§ 22-501, -3202). He seeks reversal of his convictions on the grounds that the prosecutor's conduct in examining witnesses and closing argument denied him a fair trial; the trial Judge erred in allowing inadmissible hearsay into evidence through a detective's testimony about two conversations with the surviving victim and through a witness' written statement to the police; the trial Judge's revocation of his bond during trial had a prejudicial and chilling effect on the fairness of his trial; and the trial court erred in refusing to allow defense counsel to read from the trial transcript during his closing argument. 1 We conclude after reviewing the record, Part I, that neither the prosecutor's conduct in examining witnesses nor his closing argument amounts to misconduct warranting reversal. Our Discussion of the prosecutor's closing argument, Part II, does indicate certain misconduct, but none so substantial as to require reversal; nor do we find, as appellant urges, that the cumulative effect of the prosecutor's conduct was plain error. With regard to the hearsay objections, Part III, we hold that the identification testimony was admissible under an exception to the hearsay rule, but the testimony recounting the victim's description of the assaults and the witness' police report were inadmissible prior consistent statements; their admission was not reversible error, however, in view of the witnesses' testimony, which was subject to cross-examination, and other circumstances indicating the reliability of the statements. We also find, Part IV, no prejudice to appellant as a result of the revocation of his bond at the close of the government's case. Upon review of the trial Judge's denial of defense counsel's request to read from the trial transcript during his closing argument to the jury, Part V, we decline to adopt a per se rule prohibiting such a practice, but find no prejudice to appellant and no abuse of discretion in this case. Accordingly, we affirm the judgments of conviction. I. The Government's Evidence On October 14, 1981, Gary Primrose received a letter informing him that his job application as a maintenance worker at Howard University had been accepted. He wanted to celebrate and that evening went to see his old friend Donald Moon about having a drink. Moon, who had won the numbers lottery, suggested they buy some heroin, being occasional users, and offered to pay. The two men then proceeded in search of a seller. At 14th and U Streets, N.W., a friend of Moon's joined them and they eventually approached a man who was standing in front of a Wings & Things carry-out. Moon brought "two quarters" of heroin from him. After injecting the heroin at an "oil pad" and discovering that the drugs had very little effect, they decided to try to get their money back, and returned to 14th and U Streets. They found the man who had sold them the drugs where they had left him a half hour earlier; that man, standing in front of the carry-out, was Steve Gordon. Gordon testified that earlier in the evening he had gone to 14th and U Streets and approached appellant, who was standing on the street, about "some work." Gordon had known appellant, nicknamed "Chico," for about a year as a result of prior drug transactions at 14th and U Streets. Appellant agreed to let Gordon sell some heroin, and told him to go to the corner of 13th and W Streets, where "someone would come and see ." Gordon did so, and after he waited approximately ten minutes, someone unknown to him walked by and dropped a package at his feet. The package contained five "quarter" bags of heroin. Gordon injected one of the bags, but found that the heroin had almost no effect on him. When Primrose, Moon and his friend returned to 14th and U Streets, Moon told Gordon that the heroin was "no good" and they wanted their money back. Gordon said they would have to check with "the dude across the street." Primrose recognized "the dude" as "Chico," whom he had known in high school. Gordon crossed the street to speak to appellant and then relayed to the three men that appellant said they could get their money back if they went into the alley with him. Gordon warned them not to go into the alley, but they went anyway. As Primrose, Moon and his friend entered the alley, appellant beckoned to "one of his buddies" to follow him. According to Primrose, after they went past a bend in the alley, appellant turned and punched Moon in the face, knocking him down and saying "Yes, you want me to straighten it up? I am straightening it up." Appellant and two or three of his friends continued to beat Moon, and shortly thereafter, someone hit Primrose in the face and knocked him down. Appellant also came over and started punching him and Primrose became aware that appellant was stabbing him. One or two minutes later, Gordon, who had waited across the street from the alley, saw Moon's friend run out of the alley; three of five minutes after that Moon emerged from the alley, bleeding from the stomach. At that point Gordon left the area. Primrose "hobbled" out of the alley shortly thereafter and collapsed beside Moon who as lying on the street. They were eventually taken to Washington Hospital Center where Moon died at 10:30 p.m. that night. The same night, between 9:30 p.m. and 10:00 p.m., Primrose told Homicide Detective Kilcullen that four men had stabbed him and he knew one of them as "Chico." Primrose was in the critical shock-trauma unit of the hospital and the interview had to be cut short because he was groaning in pain; he had been stabbed four times, his eyes were swollen and rolling and intravenous tubes were attached to his body. Two days later, Detective Kilcullen interviewed Primrose again. He was still in intensive care but recovering, although the intravenous tubes were still attached to his body. Primrose identified appellant from an array of ten photographs. 2Appellant was arrested two days later in a vacant lot next to the Wings & Things carry-out on 14thStreet; a knife was recovered from his rear pants pocket. The Deputy Medical Examiner, Dr. Kim, performed an autopsy on Moon's body and testified, as an expert in forensic pathology, that the cause of death was multiple stab wounds. He found ten stab wounds in Moon's body, eight of which were between 3/4 and 1 inch wide. In his opinion, all ten of Moon's stab wounds could have been caused by a knife with the same dimensions as the knife recovered from appellant. 3Dr. Kim also found a contusion on Moon's face but no indication of wounds which would have resulted from Moon trying to defend himself. Dr. Kim detected a small amount of morphine, alcohol and quinine in Moon's body, which indicated he had injected heroin, and found track marks on Moon's arm, from which Dr. Kim concluded Moon was a drug addict. 4 The Defense Evidence Appellant's defense was a combination of innocent presence and misidentification. Two of his friends testified they saw appellant in the alley on the night of the murder, but denied he had been involved with the assaults on Moon and Primrose. Appellant's mother and father testified that appellant lived at home and had often left the knife, which was on him when he was arrested, on his bureau at home; his mother also testified she had not noticed any tears or blood stains on his clothing when she did his laundry for the week in which the murder occurred. Appellant testified that he was in the alley on the night of the murder playing craps but did not know much about the assaults other than that he was not involved. Darian Patterson, a good friend of appellant's testified that he had accompanied appellant in his search for a crap game and was with appellant in the alley where the murder occurred. They had gone into the alley to gamble in a dice game with ten or fifteen other people. According to Patterson, after about an hour, and while appellant was intent upon the game, Patterson saw two men, Moon and "Penrose," approach the game. 5One of the players in the crap game stood up and confronted the newcomers. Cursing followed and one of the newcomers, Moon, punched the player in the face and knocked him down. When he fell, three of his friends, who had been gambling, pulled out knives (about five to six inches long) and began stabbing Moon and "Penrose." Then the player who had been knocked down got up and pulled out a gun. At that point, Patterson tapped appellant on the shoulder and they, and everyone else, ran out of the alley, leaving Moon and "Penrose" on the ground. The cross-examination recounted the details of the assaults and Patterson testified that Ligon, Poole, Williams and Witherspoon were also in the alley that night, but he could not remember who else was there. 6 Harold Ligon testified that he and appellant had gambled together for a couple of years. Ligon said he was already in the crap game on the night of the murder when appellant and Patterson had joined the game. Sometime later, according to Ligon, two other men approached the game and as they did, one of the players in the game stood up and punched the shorter newcomer, Primrose, and knocked him down. Primrose, cursing and stuttering, sat up and pulled out a gun. Three of the player's friends grabbed the taller newcomer, Moon, and pulled out knives. Ligon then left the alley. On cross-examination he described the details of the assaults, and changed his testimony about who else was in the alley, claiming he was confused. 7 Appellant testified he was 24 years old, lived with his parents and two sisters, had completed the eleventh grade and had been doing maintenance work for a man in the neighborhood in October of 1981. He knew Primrose from high school where they had played basketball; they were not close friends, but held no grudges. Since high school he had only seen Primrose every other month on 9th Street, 14th Street, and Georgia Avenue. Regarding the night of the murder, appellant testified he was in the alley to play craps, but had not seen Moon or Primrose and did not see the assaults. He explained that when an argument had started, he was focusing on the crap game, having won over four hundred dollars. When he looked up he saw some people in the alley "wrestling," but he did not see anyone get hit. As everyone else began to run out of the alley, he picked up all of the game money and then ran out too. On cross-examination, he denied the truthfulness of Primrose's and Gordon's testimony and claimed the arresting officer was wrong about finding a knife in his back pocket, as he kept it in his waist. He also claimed he did not know Gordon. II. Appellant alleges a variety of errors regarding the conduct of the prosecutor in questioning witnesses, offering certain evidence, and closing and rebuttal arguments. He contends the prosecutor asked his witnesses leading questions, badgered appellant on cross-examination, and grossly misstated and distorted the evidence with the result that appellant was denied due process of law and a fair trial. Our review of the record indicates that only four allegations of error merit Discussion: the prosecutor's effort to elicit testimony about fear of appellant, the prosecutor's reference to two defense witnesses who did not testify, alleged inflammatory questioning, and the closing arguments. Other allegations of error relating to the scope of examination and leading questions are matters within the sound discretion of the trial court, and we find no abuse of discretion. We first address separate allegations of error, then the closing arguments and conclude with a Discussion of the impact of the prosecutor's conduct on appellant's right to a fair trial. A. Appellant has emphasized in his claims of error the prosecutor's injection into the trial of the government witnesses' fear of appellant. One example is illustrative. He contends that the prosecutor's attempt to elicit testimony from Gordon that he was afraid of appellant was improper. Before testifying, and out of the presence of the jury, Gordon had appeared with his attorney to request a ruling on whether he had waived his Fifth Amendment privilege against self incrimination by testifying before the grand jury; he intended to assert the privilege and refuse to testify in appellant's case. When the trial Judge ruled that he had waived the privilege, Gordon's attorney asked the trial Judge to order him to testify, in the presence of appellant, under penalty of contempt, which the trial court did. The prosecutor did not mention the incident during his direct examination of Gordon. However, on cross-examination defense counsel asked Gordon when he had contacted an attorney concerning his testimony and whether his attorney had come to court with him that day. No explanation of the reason Gordon had contacted a lawyer was given. On redirect examination the prosecutor asked Gordon several questions in an attempt to elicit that he had contacted a lawyer because he was afraid to testify against appellant and sought to avoid doing so. When defense counsel objected to the prosecutor's question of why Gordon had contacted a lawyer, the trial court ruled that defense counsel had brought up the subject and the prosector could probe the area. This was correct, Johnson v. United States, 298 A.2d 516, 518 (D.C. 1972), and thus the evidence was properly before the jury. The government concedes, however, that certain questions by the prosecutor were gratuitous, although not plain error. In asking appellant whether Primrose had lied when he identified appellant as one of his assailants, the prosecutor referred to Primrose not "know whether he was going to live or die," and testifying in front of appellant while his friends were in the witness room. There was evidence before the jury that Primrose was in intensive care after the attack, but no evidence that he was, in fact, near death. The prosecutor's reference to appellant's friends in the waiting room implied that Primrose had identified Patterson and Ligon. We agree that the questions do not constitute plain error. While an objection might have been sustained, 8appellant did not object to them at trial and their allowance was not an abuse of discretion. Harling v. United States, 382 A.2d 845, 847 (D.C. 1978). Contrary to appellant's contentions, the questions were not without evidentiary basis. King v. United States, 125 U.S. App. D.C. 318, 329, 372 F.2d 383, 394 (1967) (error for prosecution to make assertions of fact to the jury, in form of question, without basis in evidence). Appellant also argues that despite a sustained objection, the prosecutor's questions concerning appellant's failure to call two witnesses (Poole and Witherspoon) were improper and require that his conviction be reversed. It is improper, under some circumstances, for a prosecutor to ask a defendant what his missing witness' testimony would have been. See Thomas v. United States, 447 A.2d 52, 58 (D.C. 1982) (citing Graves v. United States, 150 U.S. 118, 37 L. Ed. 1021, 14 S. Ct. 40 (1893)). We find no error insofar as the prosecutor was entitled to ask appellant who was in the alley since the defense witnesses, Patterson and Ligon, had contradicted each other about whether or not Poole and Witherspoon were in the alley. But when the prosecutor asked what Poole's and Witherspoon's testimony would have been and why they were introduced at voir dire as defense witnesses (to which the defendant gave no answer), the trial Judge properly sustained the defense objection. In the absence of a prior ruling on missing witnesses by the trial court, it would be improper for the prosecutor to pursue questioning which would suggest to the jury that their testimony would be adverse to appellant. We are satisfied, however, that these questions did not contribute to the conviction. United States v. Free, 141 U.S. App. D.C. 198, 202-03, 437 F.2d 631, 635-36 (1970); see Reed v. United States, 403 A.2d 725, 730 n.7 (D.C. 1979); accord Parks v. United States, 451 A.2d 591, 614 (D.C. 1982), cert. denied, 461 U.S. 945, 103 S. Ct. 2123, 77 L. Ed. 2d 1303 (1983) (prosecutor's failure to seek court permission for "missing witness" argument not "grave misconduct" since argument "did not directly urge the jury to draw . . . an inference adverse to appellant.") (quoting Fletcher v. United States, 335 A.2d 248, 250 (D.C. 1975)). The number of questions was limited and once the objection was sustained the prosecutor moved on to ask appellant about who he remembered being in the alley. We note that there was no objection by the defense to the prosecutor's question which indicated that appellant had heard everyone else testify before he took the witness stand. This court has indicated it is impermissible for the prosecutor to comment in closing argument on appellant's exercise of his Sixth Amendment right to confront witnesses. (Phillip) Dyson v. United States, 418 A.2d 127, 131 (D.C. 1980) and cases cited therein. Accomplishing the same result by cross-examination is no less objectionable, since the prosecutor thereby can also seek to have the jury draw impermissible inferences from appellant's exercise of his constitutional right to confront witnesses. See Fornah v. United States, 460 A.2d 556, 559-60 (D.C. 1983) (improper to ask defendant on cross-examination why he did not testify before grand jury). 9Such references should, therefore, be avoided in questioning. The prosecutor had been focusing on the physical evidence which was found in the alley after the murder and his questions were designed to point out that there was no evidence of a crap game; the objectionable part of the question was unnecessary to accomplish this legitimate purpose. Still we conclude that the question does not constitute plain error. It does not appear to have been prominent during the impeachment or intended, in this context, to do more than explore appellant's direct testimony about what had happened in the alley on the night of the murder. See Fornah, supra, 460 A.2d 560-61 (in closing argument, no plain error where intent by prosecutor was not to undercut constitutional rights but to suggest theory of case based on permissible inferences from evidence). B. In the event none of the several allegations of prosecutorial misconduct requires reversal, appellant contends reversal of his convictions is nonetheless required because the instances of improper conduct by the prosecutor amount to a "veil of prejudice" which deprived him of a fair trial and due process of law. We disagree. The main thrust of appellant's "veil of prejudice" claim is directed at the prosecutor's closing and rebuttal arguments. Since appellant's trial counsel did not object to either, we may reverse only if the misconduct rises to the level of plain error. Watts v. United States, 362 A.2d 706, 708 (D.C. 1976) (en banc). The analysis which is required when a claim of prosecutorial misconduct during argument is raised for the first time on appeal has been stated by this court as follows: We first evaluate for misconduct the asserted examples of improper comment. If we find that misconduct occurred, we then determine whether the erroneous statements rose to the level of "substantial prejudice." (Phillip) Dyson v. United States, 418 A.2d 127, 132 (D.C. 1980). As appellant failed to object at trial, we will reverse his conviction only if this substantial prejudice so clearly prejudiced his substantial rights as to jeopardize the very fairness and integrity of his trial. Watts v. United States, 362 A.2d 706, 709 (D.C. 1976) (en banc). McCowan v. United States, 458 A.2d 1191, 1196-97 (D.C. 1983). In determining whether the prosecutorial misconduct was substantially prejudicial and thus infected the verdict, we must employ a balancing test: The applicable test in this jurisdiction in determining whether prosecutorial misconduct infects a verdict is to balance, on the one hand, the gravity of the misconduct, its direct relationship to the issue of innocence or guilt, and the effect of specific corrective instructions by the trial court, if any, against the weight of the evidence of appellant's guilt. Villacres v. United States, 357 A.2d 423, 428 (D.C. 1976); (Duane) Dyson v. United States, 450 A.2d 432, 437 (D.C. 1982). The prosecutor began his closing argument by suggesting that appellant was on trial because he was careless in his dealings with Gordon and Primrose as evidenced by the fact they had testified against him at trial. The remainder of his argument was predominantly a restatement of the evidence and argument based on reasonable inferences therefrom, but at times, the prosecutor went beyond such inferences by referring to matters within his personal knowledge. The government has conceded as much during oral argument with respect to the prosecutor's comments about what it takes to survive at 14th and U Streets, but argues there was rhetoric on both sides in this hard fought case and nothing the prosecutor did was misconduct in view of the evidence before the jury. We agree there was considerable evidence on which the prosecutor could base his inferences about appellant's activity at 14th and U Streets. Indeed, some of the argument about which appellant now complains was based on testimony elicited by defense counsel in an effort to rebut the government's strong identification evidence. 10Thus, except as discussed below, our review of the record indicates that appellant's contentions amount primarily to a complaint about emphasis, which is insufficient here to support a finding of prosecutorial misconduct. Accord Parks, supra, 451 A.2d at 612 & n.43; Viereck v. United States, 318 U.S. 236, 247-48, 87 L. Ed. 734, 63 S. Ct. 561 (1943). The prosecutor did err in expressing his personal belief during closing argument about appellant's alleged state of mind during the offense and trial. He told the jury that appellant and his friends "thought they had left behind two dead men" and that when Gordon appeared to testify he "gave Mr. Sherrod here the surprise of his life. . . ." 11This court has admonished lawyers "to eschew personal opinions in the course of arguments to juries because this can divert jurors from their role." (Phillip) Dyson, supra, 418 A.2d at 130; McCowan, supra, 458 A.2d at 1198; Bates v. United States, 403 A.2d 1159, 1163 (D.C. 1979); Jenkins v. United States, 374 A.2d 581, 584 (N.D.), cert. denied, 434 U.S. 894, 54 L. Ed. 2d 182, 98 S. Ct. 274 (1977); Villacres, supra, 357 A.2d at 425-26; Hyman v. United States, 342 A.2d 43, 45 (D.C. 1975). The purpose of the rule that an attorney should not express his or her opinion on the ultimate issues in the case to the jury during closing argument is "to keep the focus on the evidence and to eliminate the need for opposing counsel to meet 'opinions' by urging his own contrary opinion." Harris v. United States, 131 U.S. App. D.C. 105, 107, 402 F.2d 656, 658 (1968) (emphasis in original). 12 The prosecutor's argument about the demeanor of two witnesses also contained expressions of personal opinion. While the prosecutor is entitled to comment on the witnesses' objective demeanor, he is not permitted to argue, in the absence of evidence in the record, about a witness' fear where to do so "exceeds the bounds of permissible comment by invading the province of the jury's responsibility to assess the demeanor of the witnesses." (Phillip) Dyson, supra, 418 A.2d at 130; McCowan, supra, 458 A.2d at 1198 & n.12. We do not dispute the government's contention that there was evidence on which reasonable inferences about Gordon's and Primrose's fears could be based, and in rebuttal, the prosecutor could properly respond to defense counsel's argument to the jury that the witnesses' subsequent dealings with appellant belied their fear of appellant. Medina v. United States, 315 A.2d 169 (D.C. 1974). That there was some objective evidence on which reasonable inferences about the witnesses' fears could be based does not change the rule that subjective demeanor evidence is for the jury to evaluate. (Phillip) Dyson, supra; McCowan, supra. What the jury sees in a witness' face or hears in a witness' voice is for the jury to determine, not counsel. Thus, it was improper for the prosecutor to tell the jury that it saw fear in the faces and voices of Gordon and Primrose. 13It was also improper for the prosecutor to comment that Primrose's difficulty in saying appellant's name, "Chico," was evidence of his fear; his speech difficulty is equally consistent, on the record before us, with the evidence that he stuttered, and the assessment of his difficulty was for the jury to determine. 14 As other claims of prosecutorial misconduct, appellant contends that the prosecutor's comments on the credibility of the two defense witnesses and on appellant's decision to testify last were improper. This court has held that it is error for the prosecutor to express an opinion about the veracity of a witness. (Phillip) Dyson, supra, 418 A.2d at 130; Powell v. United States, 455 A.2d 405, 408 (D.C. 1983). However, the comments challenged here were reasonable inferences from the summarized testimony of the two defense witnesses; their testimony was full of inconsistencies and the prosecutor was free to comment on them. United States v. Jones, 157 U.S. App. D.C. 158, 164-65, 482 F.2d 747, 753-54 (1973); Arnold v. United States, 467 A.2d 136, 137-38 (D.C. 1983). Conversely, as previously noted, a prosecutor's comment during closing argument on a defendant's decision to testify last has been construed by this court as an attempt to have the jury draw adverse inferences from the defendant's exercise of his constitutional right to confront witnesses and is thus impermissible. (Phillip) Dyson, supra, 418 A.2d at 131; Jenkins, supra, 347 A.2d at 584. Appellant also contends that the prosecutor grossly misstated the evidence. As an example he cites the prosecutor's argument to the jury summarizing Dr. Kim's testimony. Contrary to one of the prosecutor's statements, Dr. Kim had not expressed his medical opinion about whether any one of the stab wounds would have been fatal; his testimony was that multiple stab wounds caused Moon's death and eight of the ten wounds were deep. Hence, the prosecutor's comment amounted to unsworn testimony, which is forbidden. However, immediately following the single stab comment the prosecutor reviewed Dr. Kim's testimony in detail. There was also evidence to support the inference regarding the vicious and gratuitous nature of the assaults. Thus, we view the objectionable comment, and others cited by appellant, as being of the type described by the Supreme Court in Donnelly v. DeChristoforo, 416 U.S. 637, 646-47, 94 S. Ct. 1868, 40 L. Ed. 2d 431 (1974), and find insufficient grounds upon which to conclude the prosecutor's action should be deemed a deliberate effort to mislead the jury. 15 During a part of the prosecutor's rebuttal argument, appellant contends the prosecutor engaged in a form of argument that this court has condemned. See McCowan, supra, 458 A.2d at 1199; Powell, supra, 455 A.2d at 410 and cases cited therein. He suggests the prosecutor's comments about the way in which appellant lived, appellant's position of authority on 14th Street, his "friends," and what appellant "counted on" were designed to inflame the jury and introduce irrelevant factors, unrelated to the evidence at trial, into the jury's deliberations. We agree that some of the prosecutor's comments could better have been left unsaid, Sellars v. United States, 401 A.2d 974, 977 (D.C. 1979), but find that a substantial portion of the rebuttal argument was in response to the defense counsel's closing, which invited the prosecutor to attack the defense characterizations of the evidence, the government's witnesses and appellant. 16See Christian v. United States, 394 A.2d 1, 33 n.86 (D.C. 1978), cert. denied, 442 U.S. 944, 99 S. Ct. 2889, 61 L. Ed. 2d 315 (1979); Watts v. United States, 449 A.2d 308, 313 (D.C. 1979); Medina, supra, 315 A.2d at 170-71; Arnold, supra, 467 A.2d at 138 ("the prosecutor's comments were more in the nature of argumentation than outright expressions of personal opinion"). Viewed in context, the prosecutor's references to appellant's activities were consistent with reasonable inferences from the evidence about what he was doing on the night of the murder and what he did at 14th and U Streets. Tuckson v. United States, 364 A.2d 138, 142 (D.C. 1976); see Jackson v. United States, 329 A.2d 782, 791 (D.C. 1974). The rebuttal argument was not lengthy, and was followed by the instructions to the jury that counsel's arguments were not evidence and that the jury was the sole Judge of credibility and the facts. C. Having reviewed appellant's claims of misconduct, we consider whether the instances of prosecutorial misconduct constitute plain error. In evaluating the relationship of the misconduct to the issue of innocence or guilt, we note that the prosecutor aggressively presented the government's evidence, extensively cross-examined the defense witnesses and forcefully argued to the jury that he had proved his case. His trial performance unquestionably attacked the picture of appellant which defense counsel presented through testimony and in his closing argument to the jury. (Phillip) Dyson, supra, 418 A.2d at 129 ("It is beyond dispute that the government may prosecute vigorously and zealously."). Aspects of the prosecutor's conduct, as we have noted, should be, and we trust will be, avoided in the future. But the instances in which the prosecutor acted improperly, while not condoned, do not, as appellant urges, separately constitute plain error or add up to an impermissible course of intentional misconduct throughout the trial. 17 Thus, for example, the prosecutor's comments which involved personal opinion related to how appellant was perceived by others and did not bear directly on appellant's credibility. 18His objectionable comment that appellant testified last arose in the context of highlighting the conflicting testimony of defense witnesses. In view of this court's previous admonition to the trial court not to countenance such comments on a defendant's presence (Jenkins, supra, 374 A.2d at 584), the absence of admonition by the trial court lends some credence to the notion that, in context, the comment was not viewed as prejudicial. See Reed, supra, 403 A.2d at 730-31 n.7. Nor did the prosecutor's misstatement of the medical testimony relate directly to the innocence or guilt of appellant. The trial Judge twice instructed the jury that the arguments of counsel were not evidence. He told the jury that "in the heat of the argument may give you what they believe to be the evidence in the case," but the arguments are not evidence, they are only "the contentions of both sides." 19The trial Judge also explained the purpose of the closing arguments to the jury and repeated a second time that the arguments are not evidence. His instructions to the jury also included the standard instructions that the jury is to determine the facts, the weight, effect and value of the evidence as well as the credibility of witnesses, and that their recollection controls over references by either counsel to matters of evidence. The jury is presumed, unless the contrary appears, to follow the instructions, Smith, supra note 17, 315 A.2d at 167, and we find nothing in the record to suggest that the jury did not do so. Finally, the weight of the evidence of appellant's guilt was very strong. Not only was there an eyewitness (Primrose) to the murder and assault, but the appellant was known to the eyewitness, thus weakening his defenses of innocent presence and misidentification. The testimony of a second witness (Gordon), who saw the events immediately before and after the assaults, provided strong corroboration of the eyewitness' testimony; this witness also knew appellant from prior associations and had spoken with him on the night of the murder. Appellant's witnesses did little to strengthen his defense; his two friends not only contradicted each other on key points, but confirmed parts of the government's evidence. Appellant's own testimony placed him at the scene of the assaults and he was arrested with a knife which was similar to the weapon which inflicted Moon's wounds. Accordingly, we hold, after applying the balancing test enunciated in Villacres, that the challenged remarks were not so clearly prejudicial as to jeopardize the fairness and integrity of the trial. What appellant now terms "flagrant, egregious and intentional misconduct of the prosecutor" was either objected to by defense counsel and sustained by the trial Judge, or did not cause defense counsel to object at all. Parks, supra, 451 A.2d at 613 (failure to object "constitutes some evidence that appellants did not immediately perceive the challenged argument as prejudicial."). His allegation that the accumulation of incidents was "severely prejudicial" ignores the evidence which was before the jury as well as the active role of defense counsel and the rulings of the trial Judge. Moreover, this court has "held consistently that a determination of whether prosecutorial misconduct amounts to prejudicial error depends in good part on the relative strength of the government's case." (Duane) Dyson supra, 450 A.2d at 439 (citing Smith supra, 315 A.2d at 166); see also Reed supra, 403 A.2d at 731, and cases cited therein. We hold the errors here did not so affect the conduct of the trial as to deny appellant a fair trial, and do not rise to the level of plain error requiring reversal of his convictions. III. Appellant's second claim of error concerns hearsay evidence. He contends that the trial court committed reversible error by admitting into evidence Detective Kilcullen's testimony about two conversations with Primrose shortly after the killing, and by admitting the written statement which Gordon gave to the police shortly after the murder. Detective Kilcullen testified that on the night of the assaults Primrose identified "Chico" as one of his assailants and provided a physical description. The detective also testified that during a second interview two days later Primrose identified appellant from a photo spread and then repeated Primrose's statements about the drug sale and the attacks in the alley. No objection was made to the testimony about the second interview. 20 The testimony about the first conversation was admissible as substantive evidence under an exception to the hearsay rule for prior description testimony, Morris v. United States, 398 A.2d 333, 338 (D.C. 1978). The testimony regarding the photo spread identification at the second interview was admissible under the hearsay exception for prior identification testimony. Rice v. United States, 437 A.2d 582 (D.C. 1981). However, the testimony recounting Primrose's description of the sale and the attacks was a prior consistent statement which was inadmissible under any exception to the hearsay rule. It is well settled that prior consistent statements of a witness are inadmissible to support one's own unimpeached witness. Rease v. United States, 403 A.2d 322, 327 (D.C. 1979). Such statements are admissible "only in those 'exceptional situations' in which they can be of very clear help to the factfinder in determining whether the witness is truthful." Id. (quoting Coltrane v. United States, 135 U.S. App. D.C. 295, 304, 418 F.2d 1131, 1140 (1969)). Furthermore, if rehabilitation after impeachment is required, the evidence must be directed only at the particular impeachment involved. Rease, supra, 403 A.2d at 328. These statements are excluded because "mere repetition does not imply veracity." Coltrane, supra, 135 U.S. App. D.C. at 304, 418 F.2d at 1140. The exceptions to this general prohibition are well defined. 21The government offers no justification which would render the testimony recounting Primrose's story admissible and we can find none. 22However, the declarant, Primrose, was available for cross-examination and had in fact been cross-examined, and the detective's testimony was brief and "substantially comported with the declarant's testimony at trial." Johnson v. United States, 434 A.2d 415, 420 (D.C. 1981). Accordingly, we hold that the error in admitting the detective's testimony concerning Primrose's prior consistent statements, was not plain error. Gordon's statement to the police was also inadmissible hearsay. The prosecutor offered the statement for admission into evidence without any proffer of the justification for its admission, and the trial Judge admitted it without explanation over defense counsel's objection to its admission as hearsay. Gordon's statement to the police would have been admissible only under the exception which permits admission of a prior consistent statement if portions of the statement have been used during cross-examination to impeach the witness, and it also contains relevant information to meet the force of the impeachment. Coltrane, supra, 135 U.S. App. D.C. at 304, 418 F.2d at 1140; Sherer, supra note 21, 470 A.2d at 740 n.8. During direct examination, the prosecutor asked Gordon whether he had seen appellant after his arrest, and about the substance of any conversations they had had. Gordon replied he had seen appellant by chance on the street and that appellant had asked if he had spoken to the police. On recross-examination, defense counsel attempted to impeach Gordon, in order to show that he was not afraid of appellant, by questioning when he had first mentioned this conversation to the police or the prosecutor; defense counsel referred to the fact the statement which Gordon had given to the police did not mention a subsequent meeting. To rehabilitate Gordon's testimony, the prosecutor asked whether he had spoken with appellant before he gave the statement to the police, and Gordon replied he had not. Therefore, the only relevance of the statement was the date on which it was given and no justification existed for the admission of the entire statement simply to show the date. 23 We hold that Gordon's statement to the police was inadmissible hearsay as to all except the date, and therefore, its admission was error. The error does not require reversal, however. Although the statement was potentially prejudicial because it reinforced Gordon's credibility, there "was ample indication of the truthfulness of testimony, apart from the out-of-court , to enable the jury reasonably to have found him a credible witness." Reed v. United States, 452 A.2d 1173, 1181 (D.C. 1982). His testimony about the drug sale was consistent with Primrose's testimony and partly corroborated by Moon's wounds and the presence of heroin in his system. It was contradicted by appellant's friends, but their credibility was substantially impeached by their conflicting testimony. We note, too, that defense counsel, who first brought Gordon's statement to the jury's attention, had an opportunity prior to trial to prepare to meet the force of the statement. The trial Judge instructed the jury on the limited purpose for which the prior consistent statement was admitted into evidence and under these circumstances we conclude that any prejudice to appellant was not so substantial as to require reversal of his convictions. Id. IV. Appellant's third claim of error involves the revocation of his bond during trial. He contends that he was prejudiced by the trial Judge's decision to revoke his bond at the close of the government's case and to detain him for the remainder of the trial. 24Appellant asserts the revocation had a chilling effect on his ability to testify free from fear and that his potential witnesses were placed in fear and led to believe the trial Judge was ill-disposed towards the defense. He also contends that the revocation had a prejudicial impact on the jurors, who could not have helped but notice the change in his status, and who likely attributed the court's actions to a belief on the part of the Judge in appellant's guilt. We find no error. In Murphy v. Hunt, 455 U.S. 478, 71 L. Ed. 2d 353, 102 S. Ct. 1181 (1982), the Supreme Court held that a challenge to the constitutionality of pretrial detention is rendered moot after conviction of the underlying charges, and appellant, therefore, cannot challenge the trial Judge's authority to revoke his bond during trial. Appellant nonetheless contends that regardless of the authority of the trial Judge to take such action, the revocation constituted error because it prejudiced his right to a fair trial. Specifically, he alleges that on the first two days of trial the jurors had seen him outside of the courtroom and in the cafeteria and that his absence from those areas implied that he had been detained, which further implied that the trial Judge thought he was guilty as charged. Essentially, appellant's contentions invite this court to engage in speculation that the jurors saw appellant outside of the courtroom and, assuming they had, that his subsequent absence was noticed by them with adverse consequences. Even if his absence was noticed, it is pure speculation to suppose that jurors would conclude he was not in the cafeteria because his bond had been revoked. 25Moreover, the trial Judge instructed the jury that it must not view his actions or comments as indicating either how he wanted the jury to determine the issues or facts, or his opinion or view of the facts. Our review of the record fails to uncover support for appellant's claim that he or his witnesses were hindered in their ability to testify, and we decline to speculate on the basis of appellant's unsupported assertions. Therefore, we find that appellant has not shown that prejudice resulted from his detention. Watts v. United States, 449 A.2d 308, 311 (D.C. 1982); Bostick v. United States, 400 F.2d 449, 452 (5th Cir.), cert. denied, 393 U.S. 1068, 21 L. Ed. 2d 712, 89 S. Ct. 725 (1969). V. Appellant's fourth claim of error relates to the use of trial transcripts during closing argument. He argues that the trial Judge's refusal to let defense counsel read from the trial transcripts of Primrose's and Gordon's testimony during his closing argument was extremely prejudicial because he could not otherwise overcome the prosecutor's alleged distortions of the evidence. The trial Judge had initially agreed to let defense counsel read from the trial transcripts during his closing argument. When the prosecutor objected on the basis that this would highlight portions of the evidence in contravention of the rule that the juror's memory controls, the trial Judge ruled that defense counsel would be allowed only to refer to the transcript during his closing argument. In support of his position appellant relies on two cases which are inapplicable insofar as both concern the trial court's discretion to read portions of the transcript back to the jury upon the jury's request. United States v. McCoy, 517 F.2d 41, 44 (7th Cir. 1975); Stone v. United States, 506 F.2d 561 (8th Cir. 1974). Both courts concluded, however, that the issue was committed to the sound discretion of the trial court. 26 There is precedent for allowing counsel to read portions of the transcript during closing argument. United States v. Kuta, 518 F.2d 947, 954 (7th Cir.), cert. denied, 423 U.S. 1014, 46 L. Ed. 2d 385, 96 S. Ct. 446 (1975) ("no reason to establish per se rule penalizing accuracy"); Byrnes v. United States, 327 F.2d 825, 840 (9th Cir.) cert. denied, 377 U.S. 970, 12 L. Ed. 2d 739, 84 S. Ct. 1652 (1964) ("only safe way to be accurate" is to read trial transcription of witness' testimony). 27At least one court has held that the discretionary right of the trial court to read testimony can be delegated to counsel. Bing Fa Yuen v. State, 43 Md. App. 109, 403 A.2d 819, 826 (1979). We are aware of only one jurisdiction which has adopted a per se rule prohibiting counsel from reading from the record. People v. Hoggs, 17 Ill. App. 3d 67, 70, 307 N.E.2d 800, 802 (1974) (improper to read from a trial transcript during closing argument since jury "must pass upon the whole testimony free of the over-emphasis given any portion of it by verbatim repetition during the trial's waning moments."). It seems to us that the better rule leaves the question of whether counsel may read from the transcript during closing argument to the sound discretion of the trial court. The use of transcripts is already permissible, subject to appropriate checks against distortion and unfairness to or embarrassment of a witness, during the presentation of evidence. Under Super. Ct. Crim. R. 15(e)(2), permitting use of a deposition to impeach a witness, the adverse party is allowed to require that all of the relevant portions of the deposition be introduced and also to introduce any other parts. Impeachment is, of course, also permitted by use of transcriptions from a first trial upon a retrial, Ibn-Tomas v. United States, 407 A.2d 626, 644-46 (D.C. 1979), and where a prior inconsistent statement is involved, a limiting instruction may be required. Brooks v. United States, 448 A.2d 253 259 (D.C. 1982); Lofty v. United States, 277 A.2d 99 (D.C. 1971); Johnson v. United States, 387 A.2d 1084 (D.C. 1978) (en banc). Insofar as there is concern that allowing counsel to read from a transcript will unduly emphasize selected portions of the evidence, we find persuasive the observation by the United States Court of Appeals for the Seventh Circuit, regarding the trial court's reading of portions of transcripts upon jury request: "The concern for undue emphasis is even less where the reading occurs in the context of closing arguments which review the entire evidence for the jury." Kuta, supra, 518 F.2d at 954. See supra note 27. Moreover, under the procedure we suggest below, the trial court can take appropriate steps to address that concern. The interest at stake is the broad right of argument by counsel to the jury. Bing Fa Yuen, supra, 43 Md. App. 109, 403 A.2d at 826. Under our adversary system, counsel are already permitted to make closing arguments to the jury presenting their contentions about what the evidence shows with relatively few restrictions. Super. Ct. Crim. R. 29.1; Powell, supra, 455 A.2d at 408 (counsel are presumed to know the rules of the court and of their profession); Harling, supra, 382 A.2d at 847 (proper scope of closing argument subject to broad discretion of trial court). By arguing in the manner they think will best impress the jury of the merits of their case, counsel's contentions invariably highlight portions of the evidence. As long as they do so without misrepresentation or unfair or dilatory tactics, and opposing counsel has the opportunity to respond, we see no compelling reason to adopt a per se rule prohibiting counsel from reading a portion of the transcript during closing argument. Accordingly, we think the better practice would be for counsel, prior to the commencement of closing arguments, to make a proffer to the trial court of what portions of the transcript he intends to read and for what purpose. By so doing, and allowing opposing counsel to be heard on the request, the trial court can exercise its discretion, placing any appropriate limitations on out-of-context readings of what purports to be an official record of what was said. The trial Judge can evaluate counsel's proffer and determine the likelihood of prejudice if the transcript is or is not read. See Bing Fa Yuen, supra, 43 Md. App. 109, 403 A.2d at 825-26 (trial court must be given proffer as to what portions of the transcript counsel intends to read and for what purpose, must actually exercise its discretion, and cannot automatically exclude the use of transcripts). Save in extreme circumstances, we see no reason for the trial court not to permit counsel to read portions of a transcript, especially when opposing counsel will have an opportunity, if desired, to read additional portions of the transcript to supply allegedly missing context. A trial Judge does not, however, necessarily abuse his discretion when he denies such a request. On the record in the instant case, we find no abuse of discretion by the trial Judge. Defense counsel was permitted to refer to the trial transcripts as an aide to his memory in incorporating comments on the witnesses' testimony in his closing argument. He in fact referred to the witnesses' testimony in his closing argument and we find no evidence of prejudice to appellant. Affirmed. 1. Appellant also argues that his sentence should be vacated and his case remanded with instructions to resentence him on the ground that the trial Judge erred in concluding that he had no discretion to sentence appellant to probation upon his conviction for first degree murder. This court considered and rejected that argument in Beale v. United States, 465 A.2d 796 (D.C. 1983). In discussing the District of Columbia's first degree murder statute, the court noted that Congress has consistently recognized that first degree murder must be punished by the harshest penalty allowed by law. We conclude it would be impossible for this court in the face of such Congressional action to authorize a sentencing Judge who sentences a first degree murderer to life imprisonment then to suspend execution of this sentence and to place such defendant on probation. . . . e, nevertheless deem the Congress to have fixed the severity of the sentence for first degree murder in recognition of the uniqueness of the crime and we must treat such Congressional action as conclusive. Beale, supra, 465 A.2d at 806. We note that appellant filed his main brief on May 23, 1983, before Beale was decided on June 20, 1983; the government relied on Beale in its brief and appellant did not attempt to distinguish it in his reply brief. 2. Prior to trial, Primrose identified appellant at a lineup and identified Gordon from a photograph as the man from whom Moon had bought heroin. Gordon also identified appellant from a lineup photograph. 3. Appellant's knife was 3 3/4" long, with a blade 3/4" wide. Dr. Kim testified that the size of Moon's wounds were consistent with the impact of a knife with a blade 3/4" wide, noting that such a knife could cause a wound deeper than 3 3/4" as well as wider than 3/4", in the process of pulling the blade out of the body. Five of Moon's wounds were exactly 3/4", three were approximately 1" wide. 4. Gordon and Primrose were cross-examined about their drug use in general and their intoxication on the night of the murder. They were also impeached by prior convictions, primrose for possession of implements of crime in 1979, and Gordon for grand larceny in 1982 (for which he was on parole when he testified in this case) and second degree burglary and attempted robbery in 1976. 5. Patterson testified one man was wearing a baseball cap and dark sunglasses, and both were about 5' 11". Ligon, another defense witness, testified that one of the two men who approached the game had on a cap and sunglasses; the other stuttered and was approximately 5' 5", 140 pounds. Primrose had testified that he had been wearing a hat that night, and a picture of his hat, which was found in the alley, was shown to the jury; it was not a baseball cap. 6. Patterson admitted, on direct and cross-examination, that he had previously been convicted for second degree burglary in 1982. 7. On direct examination he testified that Williams was in the alley, but on cross-examination he first stated that Poole and Witherspoon were in the alley, then changed his mind and finally said that he did not know who was in the alley that night other than appellant and Patterson. In rebuttal, the government offered a stipulation of the parties that Witherspoon was in jail on the evening of the murder. On direct and cross-examination, Ligon admitted he had been convicted of armed robbery in 1981 in Maryland. 8. This court recently stated that cross-examination which recapitulates earlier testimony and culminates in the witness' response that he is truthful and the contrary witnesses are lying is inappropriate because "one witness may not express a view or an opinion on the ultimate credibility of another witness' testimony." Carter v. United States, 475 A.2d 1118, slip op. at 15-16 (D.C. March 26, 1984). The authorities relied on in Carter make it clear that a witness, whether expert or lay, may not state an opinion on another witness' credibility since the issue of credibility is for the trier of fact. See, e.g., Lilly, An Introduction to the Law of Evidence, § 29 at 89 (1978); Kenion v. United States, 302 A.2d 723, 724 (D.C. 1973) (credibility for trier of fact). However, since Carter speaks of a prospective prohibition against this manner of questioning, noting that the practice of recapitulation on cross-examination has been permitted by the trial court, our review here is for abuse of discretion and prejudice. 9. See also Grunewald v. United States, 353, U.S. 391, 421-22, 425 (1957) (use on cross-examination, over defense objection, of Fifth Amendment constitutional privilege to reflect on defendant's credibility held error); (Black, J. Concurring) ("I can think of no special circumstances that would justify use of a constitutional privilege to discredit or convict a person who asserts it."). 10. Through cross-examination of the police officers, the defense elicited evidence that a lot of illegal activity and numerous knives could be found at 14th and U Streets. In closing argument, defense counsel suggested this evidence bolstered appellant's defense of misidentification and lessened the probative value of his possession of a knife similar to the murder weapon. 11. Defense counsel told the jury in his closing argument that appellant was not surprised that Gordon had testified at trial since Gordon had testified against him at the grand jury. The prosecutor objected at the close of the defense counsel's argument, because of the reference to the grand jury testimony, but declined to ask for a mistrial. 12. The attorney's "personal belief has no real bearing on the issue; no witness would be permitted to so testify, even under oath, and subject to cross-examination, much less the lawyer without either." Harris, supra, 131 U.S. App. D.C. at 107, 402 F.2d at 658 (quoting H. Drinker, Legal Ethics 147 (1953)) (footnotes omitted). As Chief Justice Burger, then Circuit Judge, concluded in Harris, The personal evaluations and opinions of trial counsel are at best boring irrelevancies and a distasteful cliche-type argument. At worst, they may be a vague form of unsworn and irrelevant testimony. 131 U.S. App. D.C. at 108, 402 F.2d at 659. 13. In Hyman, supra, 342 A.2d at 45, this court held improper the prosecutor's comment to the jury: "You saw [the witness'] demeanor on the stand yesterday. I think you can fairly conclude that he appeared almost irrational." 14. In (Phillip) Dyson, supra, 418 A.2d at 130 the prosecutor "characterized the witness' pause as an opportunity to fabricate." This court held the prosecutor had "exceeded the bounds of permissible comment. . . ." 15. Appellant also alleges error in the comments by the prosecutor describing Primrose as a man who lived a normal life ("except he sometimes takes heroin") "and didn't put on a fancy three-piece suit and try to be something that he isn't." Although these comments were unnecessary and irrelevant, we do not find them prejudicial in view of defense counsel's cross-examination of Primrose. See Villacres, supra, 357 A.2d at 426, n.2 (examples of "boring irrelevancies"). Appellant further contends that the prosecutor expressed his personal belief of appellant's guilt, but our review of the record indicates that the prosecutor emphasized the strength of the government's case and the weaknesses of the defense witnesses' testimony. See (Phillip) Dyson, supra, 418 A.2d at 132. 16. Defense counsel's argument questioned, for example, whether the government had disclosed all of the relevant evidence and compared the appellant, a man without a prior criminal record who occasionally gambled, with the government witnesses (Primrose and Gordon) who were heroin users with prior criminal records. 17. Appellate counsel stated at oral argument that unfounded assertions about a witness's fear of the accused can be extremely prejudicial and may be impossible to overcome in a trial before a jury. Such concerns should, nevertheless, first be addressed to the trial court. If done in a timely manner, corrective measures can be undertaken by the trial court. Harris, supra, 131 U.S. App. D.C. at 105-06, 402 F.2d at 656. This court has noted that: It is peculiarly within the knowledge of the trial Judge whether remarks of counsel during the trial tend to prejudice the cause of a party. The courtroom atmosphere, prior remarks which have provoked the questioned statements, and other factors which cannot be appraised by a reviewing court may render remarks of counsel innocuous, although they may appear viciously prejudicial when removed from their setting. Smith v. United States, 315 A.2d 163, 167 (D.C.), cert. denied, 419 U.S. 896, 95 S. Ct. 174, 42 L. Ed. 2d 139 (1974) (quoting United States v. Goodman, 110 F.2d 390, 394 (7th Cir. 1940)); Harling, supra, 382 A.2d at 847 (proper scope of closing arguments subject to broad discretion of the trial Judge). In the absence of objection at trial, appellate counsel face the difficult task of demonstrating that the error complained of is "so clearly prejudicial to substantial rights as to jeopardize the very fairness and integrity of the trial." Watts, supra. 18. Compare, for example, Villacres, supra, where the prosecutor supplied a confession by the accused to his mother when none was in evidence. Accord Parks, supra, 451 A.2d at 613. 19. The instruction was: Now, the law is an advocacy and counsel, in making closing arguments, many times in the heat of the argument may give you what they believe to be the evidence in the case. Now, you have just listened before lunch to the closing arguments of each counsel. Counsel in their closing arguments gave you what they thought to be the evidence. You are reminded that the arguments you have just heard, one, are not evidence, they are not evidence. Those arguments were intended and, as I said, even when counsel gives his opinion of what the evidence was, that's his opinion. They are only given and intended to aid you in determining and deciding and understanding the evidence, that's all, and to give you the contentions of both sides. 20. Appellant asserts that the objection made to the description statements elicited at the first interview was a sufficient objection to the testimony about the statements from the second interview. We disagree. The statements from the second interview, and the basis for the evidentiary objection, were separate and distinct from the prior testimony and objection. Counsel did not object to those statements, and, therefore, the plain error standard applies. Watts, supra. 21. First, if a witness is impeached by a showing that the witness has reason to lie in court, then an out-of-court consistent statement can be introduced if the out-of-court statement was made at a time, or under circumstances, in which the witness had no reason to lie. Reed v. United States, 452 A.2d 1173, 1180 (D.C. 1982) (court erred in admitting prior consistent statement that did not antedate alleged motive to lie); Copes v. United States, 120 U.S. App. D.C. 234, 345 F.2d 723 (1964) (court did not err in admitting prior consistent statement made at a time when, although witness had same reason to lie as she did at trial, she believed herself to be dying). Second, if "the witness' testimony has been impeached by a portion of a statement which also contains relevant information that could be used to meet the force of the impeachment," such additional relevant information from the statement is admissible even though it constitutes a prior consistent statement. Rease v. United States, 403 A.2d 322, 328 n.7 (D.C. 1979) (per curiam) (citations omitted). Sherer v. United States, 470 A.2d 732, 740 n.8 (D.C. 1983). 22. See United States v. Muscato, 534 F. Supp. 969 (E.D.N.Y. 1982) (Weinstein, C.J.) (discussing the definition of hearsay, under the federal rules of evidence, in terms of its function in the development of the government's case). 23. This is not a situation, as in Sherer, supra, in which defense counsel impeached the witness on the details contained in the prior statement, by pointing out discrepancies and then arguing that these differences, between the prior statement and the witness trial testimony, indicated that the witness' testimony was a fabrication. The prosecutor in Sherer was permitted on redirect to rehabilitate the witness by examining him more fully about the statement to show that the trial testimony was generally consistent with the prior statement and that the testimony, therefore, could be credited even though several of the details were incorrect. 470 A.2d at 740. In the instant case the issue raised by defense counsel related to when Gordon's statement was given, not to the details in the statement concerning what happened on October 14, 1981. Consequently, the recounting of those events in Gordon's statement was inadmissible hearsay. 24. Appellant was arrested and presented on October 18, 1981, when he was ordered released on the condition that he post a surety bond of $2,000. He did, and was released. Prior to trial, on July 29, 1982, the government filed a "Motion for Review of Conditions of Defendant's Release on an Expedited Basis" which appellant opposed, and the trial Judge took under advisement. At the beginning of appellant's trial, on September 2, 1982, the trial court heard argument on the motion at the government's request and continued the matter under advisement. When the prosecutor renewed his request for bond revocation at the end of the government's case-in-chief, the trial Judge ordered appellant detained over objection by defense counsel. Appellant did not appeal the revocation of his bond pursuant to D.C. Code § 23-1324 (1981). 25. The trial Judge permitted him to continue to wear civilian clothes during the trial. 26. This view is also followed in three other circuits: United States v. Pollak, 474 F.2d 828, 832 (2nd Cir. 1973); United States v. Chicarelli, 445 F.2d 1111, 1114-15 (3rd Cir. 1971); United States v. De Palma, 414 F.2d 394, 396 (9th Cir. 1969), cert. denied, 396 U.S. 1046, 90 S. Ct. 697, 24 L. Ed. 2d 690 (1970). Cf. Standards Relating to Trial by Jury (ABA Project on Minimum Standards of Criminal Justice) § 14-4.2(a) (2d Ed. 1982 Supplement, Vol. III) (ABA 1982) (whenever the jury's request is reasonable, the court shall have the requested parts of the testimony read to the jury). 27. See, e.g., Floen v. Sund, 255 Minn. 211, 218, 96 N.W.2d 563, 567 (1959) (in personal injury case, "a portion of physician's testimony read to jury to refresh their recollection"); Randall v. Steelman, 294 S.W.2d 588, 594 (Mo. App. 1956); Douglas v. Duvall, 5 Utah 2d 429, 431; 304 P.2d 373, 374-75 (1956) (in civil action for damages from false representation) (Wade, J. Concurring): It would no more be undue emphasis for him to read an accurate statement of the testimony than it would for counsel to state his recollection thereof. True, such reading might be more impressive on the jury but only because they would be more impressed by an accurate statement of the testimony than they would be by a statement from memory of counsel's version of such testimony. To hold that such is a valid reason for denying the right to read from a transcript is to place a premium on inaccuracy and invite incorrect findings of fact. Contra, People v. Willy, 301 Ill. 307, 328, 133 N.E. 859, 866 (1921); People v. Hoggs, 17 Ill. App. 3d 67, 70, 307 N.E.2d 800, 803 (1974) (only "paraphrased recapitulation of testimony" based on recollection from counsel's own notes is permissible).
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Changes in The First Responder Network (FirstNet) and Next-Generation Communications for Public Safety: Issues for Congress from July 28, 2016 to January 26, 2017 - EveryCRSReport.com The First Responder Network (FirstNet) and Next-Generation Communications for Public Safety: Issues for Congress Changes from July 28, 2016 to January 26, 2017 This page shows textual changes in the document between the two versions indicated in the dates above. Textual matter removed in the later version is indicated with red strikethrough and textual matter added in the later version is indicated with blue . The First Responder Network (FirstNet) and Next-Generation Communications for Public Safety: Issues for Congress (R42543) Contents Introduction The Request for Proposal and Latest Developments FirstNet Network Strategy Network Design State Public Safety Radio Networks State Participation: The Opt-Out Provision State and Community Network Participation Risks and Rewards Advantages of FirstNet's Comprehensive Network Strategy Other Advantages Disadvantages of FirstNet's Comprehensive Network Strategy NTIA Grant Programs State and Local Implementation Grant Program Network Construction Fund GAO Study OIG Report on FirstNet Discussion of Other Provisions in the Spectrum Act to Improve Public Safety Communications Spectrum Assignment Public Safety Trust Fund FirstNet: Limit on Expenditures FirstNet: Fee Income and Other Revenue Planning Authority Statutory Obligations Time Frame Next Generation 9-1-1 Roaming and Priority Access Within the 700 MHz Band Legislation in the 115 th Congress Figures Figure 1. Small Cell Neighborhood Micro Network Summary Congress included provisions in the Middle Class Tax Relief and Job Creation Act of 2012 ( P.L. 112-96) for planning, building, and managing a new, nationwide, broadband network for public safety communications, by creating the First Responder Network Authority (FirstNet). The act allocated 10 MHz of additional radio frequency spectrum to accommodate the new network and required that the Federal Communications Commission (FCC) assign a license to FirstNet, comprising the newly designated frequencies plus 10 MHz previously assigned to states by the FCC for public safety use. In addition, the act designated federal appropriations of over $7 billion for the network and other public safety needs. These funds are provided through new revenue from the auction of licenses to the commercial sector in other spectrum bands. The establishment of FirstNet is an important step toward reaching what has been a national goal since September 11, 2001: the provision of interoperable communications for first responders. The immediate goal for FirstNet is to provide a broadband network nationwide to carry data, although it will provide an option for voice communications as well. The cost of constructing and maintaining a nationwide network is estimated by many experts to be in the tens of billions of dollars over the long term. The law anticipates that most of these costs will be covered by partnerships between FirstNet and the private sector in return for commercial access to FirstNet's spectrum. In order to maintain control over the quality and nature of communications, many states are likely to continue to invest in and maintain their own Land Mobile Radio (LMR) networks that operate on narrowband frequencies under the jurisdiction of state and local public safety agencies. Information available to the public indicates that FirstNet intends to discourage states from building and operating their own networks within FirstNet, in part by limiting the amount of spectrum available for this purpose. FirstNet has taken the position that state autonomy in network design decisions and management will jeopardize FirstNet's ability to provide a network that meets its coverage and service goals. P.L. 112-96 was signed into law on February 22, 2012, setting in motion the process of setting up FirstNet as an "independent authority within the National Telecommunications and Information Administration," as required by the act; laying out the parameters for partnerships and state, tribal, and federal participation; and meeting requirements either statutory or practical. After extensive consultation with stakeholders and potential partners in preparing proposals for partnering with FirstNet, the initial phases of organization culminated with the deadline for submitting proposals to build and operate the nationwide network, on May 31, 2016. The successful bidder for the contract to build and operate FirstNet may be announced as early as November 2016. Once the contract is awarded, as the network becomes operational, the potential level of public safety agency participation should be better understood, providing opportunities to evaluate the success of FirstNet in meeting the goals Congress set for it in 2012. Among the provisions of the act is a requirement that the Government Accountability Office, before the end of FY2022, recommend to Congress what actions should be taken in regard to the ending of FirstNet's authority, mandated for review by 2027. Congress continues to exercise vigilance in On November 21, 2016, one of the FirstNet bidders eliminated from consideration, Rivada Mercury, filed a lawsuit in the U.S. Court of Appeals of Federal Claims over what Rivada says is the illegal and wrongful exclusion of the consortium from the FirstNet procurement process. The lawsuit is expected to delay the contract award until March 1, 2017, at the earliest, although further delays are possible depending on the resolution of the lawsuit. Once the contract is awarded, the contractor will have up to 180 days to deliver detailed deployment plans to each state and territory. Governors will then have 90 days to decide whether to opt in to FirstNet or to opt out and build their own Radio Access Network which must be interoperable with FirstNet. As FirstNet becomes operational, the potential level of public safety agency participation should be better understood, providing opportunities to evaluate the success of FirstNet in meeting the goals Congress set for it in 2012. The 115 th Congress will likely continue monitoring the development and deployment of FirstNet through periodic hearings in both the House and Senate. The First Responder Network (FirstNet) and Next-Generation Communications for Public Safety: Issues for Congress Introduction The First Responder Network Authority (FirstNet) is a federal agency that includes private sector and other non-federal representation on its board of directors. FirstNet was created by Congress with provisions in Title VI (Spectrum Act) of the Middle Class Tax Relief and Job Creation Act of 2012 ( P.L. 112-96) to ensure the deployment and operation of a nationwide, broadband network for public safety communications. It is established as an "independent authority" 1within the National Telecommunications and Information Administration (NTIA), part of the Department of Commerce. In addition to establishing the structure and goals for FirstNet, Congress provided $7 billion for cost s costs related to planning and deploying the broadband network, and a $135 million grant program to assist states with plans to connect to FirstNet's broadband network. 2 These funds are provided from revenue realized through auctioning licenses for radio frequency spectrum, as designated in the act. The anticipated cost of building and operating a nationwide core broadband network—and the interoperable radio networks that connect to it—is significantly in excess of the amount appropriated. The act therefore provides for public-private partnerships with FirstNet or with states, and for fees (charged to states and other users) to ensure that FirstNet becomes self-sustaining. To attract private sector partners, FirstNet can offer access to its assets, including radio frequency spectrum capacity, in return for financial payment or other support. FirstNet holds a license for 20 MHz of broadband spectrum, 3 assigned by the Federal Communications Commission (FCC), as required by the act. The act allows states that meet specified requirements to lease spectrum from FirstNet and thereby negotiate their own partnerships that share spectrum in Radio Area Networks for their state or region. The act requires that FirstNet deploy its network using the fourth-generation wireless technologies of Long Term Evolution (LTE). 4 LTE is a powerful cellular technology with industry standards that are consistently being upgraded to expand its capabilities. LTE is also a platform for commercial carrier-expansion into fifth-generation (5G) wireless communications and the Internet of Things. There are many challenges for public safety leaders and policymakers in establishing the framework for a nationwide network that meets state, local, tribal, and territorial needs for robust, interoperable emergency communications. Currently, for example, state emergency communications needs are typically met by separate networks using different technologies. Furthermore, each state has its own laws and procedures for building, managing, and funding communications infrastructure. Among the challenges facing FirstNet is establishing a governance model that accommodates current investments and future needs of its clients without compromising the coherence of a national network. The Request for Proposal and Latest Developments FirstNet officials face enormous pressure to produce a functional network in a timely manner, reflecting widespread concerns that public safety communications will not be adequate for response and recovery if a catastrophic national emergency occurs. Among the timelines that the winning bidder 5must meet is geographical coverage for 95% of the country within six months of receiving the contract. This obligation suggests that participation of one of the four nationwide carriers (Verizon, AT&T, Sprint, T-Mobile) to carry FirstNet traffic will be essential, even if the carrier acts as a subcontractor and not a lead partner. Agreements with rural carriers may also be used to meet rural coverage goals. The winning contractor must guarantee priority access to public safety on the 20 MHz of spectrum capacity that FirstNet brings to the table. The requirements for buildout using FirstNet spectrum (referred to as Band 14) are 20% coverage of population within the first year of operation and 60% coverage within two years. Also within six months, the winning contractor is expected to submit simultaneously to 56 states and territories, as required by the act, a plan for how FirstNet would be deployed within that state or territory (tribal areas are covered in state plans). FirstNet will make available $6.5 billion of its federal funding for the buildout. The bidder must indicate the cost of each state's buildout within the context of its cost model. States that successfully meet the criteria to build their own network within FirstNet will be eligible for a proportionate share of the $6.5 billion, 6provided in the form of a grant. The total cost to build out the network is estimated by most experts to be in excess of $30 billion over 10 years. The successful bidder will sign a contract for 25 years, expiring in FY2042. Annual payments totaling at least $5.625 billion over the period of the contract are required as a guarantee that FirstNet will be financially self-sustaining. Although the bid may be awarded as early as November 2016, 7the decision may be delayed if additional time is needed to evaluate the proposals. On October 17, 2016, two of the bidders—Rivada Mercury and pdvWireless—were informed by the U.S. government that their proposals had been eliminated from consideration. This leaves AT&T as the one publically known bidder still in consideration. 7 On November 21, 2016, Rivada Mercury filed a lawsuit against the U.S. government in the U.S. Court of Appeals of Federal Claims over what Rivada says is the illegal and wrongful exclusion of the consortium from the FirstNet procurement process. 8The lawsuit is expected to delay the contract award until March 1, 2017, at the earliest, although further delays are possible depending on the resolution of the lawsuit. 9 FirstNet Network Strategy Achievements since the FirstNet board first met officially in September 2012 include a number of Requests for Information (RFI), notably the September 2014 Request for Information for Comprehensive Network Solution(s). 8 10 This document proposed a comprehensive broadband network solution for FirstNet that would reach from core network management requirements to include local area networks in many communities, as well as some devices used to access the network. 9 11 A Second Notice , issued by the Department of Commerce for comment on March 9, 2015, 10 12 provided FirstNet's perspective on the intent of Congress in enacting language that allows states to build their own network networks . The discussion in the Second Notice also supplemented the Public Notice on Statutory Interpretations , 11 13 issued in September 2014. A number of important issues are raised in these formal statements of proposed interpretation, including possible definitions of "public safety" and "rural." A third public notice 12 14 concerning the definition of "public safety" was released after a FirstNet board meeting on April 24, 2015. 13 15 Also on April 24, the proposed acquisition approach 14 16 and the draft Request for Proposal(s) (RFP) 15 17 were considered in a closed meeting. The draft RFP builds on proposals from previous notices and RFIs. The planning process for 2015-2016 centered on circulating the draft Request for Proposal(s) and a final RFP. FirstNet concluded that the contract or contracts would be awarded through the Federal Acquisition Regulation (FAR) process. 16 18 According to FirstNet, "key goals are to meet the needs of public safety and to provide extensive coverage so Federal subscribers and other public safety users can count on the network when they are on the job." 17 19 Network coverage includes deployable units, such as vehicles equipped to connect with the network, and local area networks operated by FirstNet. "Incident commanders and officials will have local control over the network so, for example, they can assign users and talk groups and determine who can access applications." 18 20 The underlying premise of the strategy is that the chosen network solutions will allow FirstNet to "control and operate" national and regional core network infrastructure, Radio Access Networks (RANs) in states that opt - in, as well as devices, applications, and other functions. 19 21 To achieve this level of coverage, FirstNet's "acquisition strategy centers on maximizing the network's value to public safety while meeting its financial sustainability obligations under the Act." 20 22 Network Design Although many details have not been made public, the general architecture of FirstNet's broadband network has been presented at numerous public events and is available on the FirstNet website. 21 23 The network design shows what is referred to as a heterogeneous network, or HetNet. It depicts the Radio Access Network to include both macro and micro networks. In simple terms, high towers with base stations, known as eNodeB in LTE network design, are referred to by the wireless industry as a macro network; a variety of small cell 22 24 network designs are referred to as micro networks. The macro network is often described as providing coverage over distance and the micro network as providing capacity as well as extra coverage at the local level. 23 25 Figure 1. Small Cell Neighborhood Micro NetworkSource:4G Americas, Meeting the 10 0 0X Challenge: The Need for Spectrum, Technology and Policy Innovation,October 2013, Figure AI-1, p. 130, http://www.4gamericas.org/ documents/ 2013_4G%20Americas%20Meeting%20the%201000x%20Challenge%2010%204%2013_FINAL.pdf .Revised by CRS to include a small cell deployment for public safety operations. The trend in the evolution of network coverage is depicted in Figure 1. In this configuration, the micro network has become the predominate provider of mobile communications coverage and capacity through contiguous small cell networks. The tower of the macro network (eNodeB) assures nationwide connectivity and provides additional coverage. Small cell networks are by and large autonomous, providing coverage for their area and connecting to other small cell networks or cellular towers when needed. These micro networks are local in nature but fully interoperable across wide geographic areas. For FirstNet, a network strategy that shifts the majority of routine, public safety mobile communications onto shared spectrum in small cell networks will free much of the 20 MHz spectrum license for secondary use by commercial carriers. Only in times of a major emergency would public safety users make heavy demands on the macro network and spectrum licensed to FirstNet. In an LTE network, it is the eNodeB macro coverage infrastructure—not the micro network—that requires a significant spectrum assignment to operate efficiently. During the period 2011-2012, when the Spectrum Act was drafted and enacted, the Radio Area Network would have consisted primarily of high-site towers with base stations (eNodeB). 24 26 Since the Spectrum Act was passed, communications technologies have evolved in ways not fully anticipated at the time. 25 27 Congress, therefore, may have assumed that a state with a successful plan to opt out and create its own public-private partnership would be granted a statewide license for 20 MHz to operate a Radio Area Network using eNodeB towers and base stations. Micro networks, however, can operate within the 20 MHz assignment, essentially sharing the spectrum, but may require no more than 1.5 x 1.5 MHz for a basic LTE network. Therefore, if FirstNet decides that only micro network capacity will be made available for a state-operated Radio Area Network, then the state will have a sub-license for a relatively small amount of spectrum that may be difficult—perhaps impossible—to leverage in a public-private partnership. State Public Safety Radio Networks Since September 11, 2001, state and local agencies—aided by federal grant programs—have invested in improving the reliability and interoperability of mission critical voice communications over Land Mobile Radio (LMR) networks. The 2014 National Emergency Communications Plan 26 28 prepared by the Department of Homeland Security emphasizes the need to continue investment in these networks to provide communication for first responders until such time as FirstNet is deployed and capable of handling mission-critical voice communications over broadband. 27 29 These networks may also be essential for local and state backup service when access to FirstNet has been preempted by a large-scale emergency, or they may be an alternative to using FirstNet. State Participation: The Opt-Out Provision FirstNet is required to consult with regional, state, tribal, and local authorities regarding decisions such as those concerning the costs of the policies it formulates, as required in the law, including expenditures for the core network, placement of towers, coverage areas, security, and priority access for local users. Consultation will be through a state-selected coordinator as specified in the act. 28 30 Appointment of an individual or governmental body as the Single Point of Contact (SPOC) is required as a condition of state participation and eligibility to receive grants established by the act. 29 31 Every state has one or more agencies that plan for public safety, homeland security, and emergency communications. To be eligible for grants from the Department of Homeland Security, a state establishes a Statewide Interoperability Coordinator (SWIC) to administer its Statewide Communication Interoperability Plan ( SCIPs). 30 SCIP). 32 SCIPs are written to conform with federal guidelines and requirements, such as the National Emergency Communications Plan. States may decide to use the existing SWIC as the required single point-of-contact or may choose to appoint a separate coordinator. Each state and other participants have appointed a coordinator to work directly with FirstNet. 31 33 The coordinator (SPOC) is responsible for managing FirstNet activities in his or her state. Often this includes revising the existing SCIP to include broadband communications. The governor of each state is to be notified by FirstNet when it has completed its requests for proposals regarding construction, operation, maintenance, and improvement of a nationwide network. The governor or his designee will receive the details of the proposed plans and notification of the amount of funding available to the state if it participates in the FirstNet program. 32 34 The act only identifies two options for a state: join FirstNet or build a statewide Radio Access Network subject to the provisions of the act. The act does not include specific provisions for a state that chooses to build its own Radio Access Network without opting out of FirstNet, although providing such an option may be within FirstNet's charter. A state might, for example, choose to build its own data management center or mobile access routers while also sharing FirstNet's infrastructure for regional and national coverage. The act also is silent on whether states may choose to opt out of the broadband network entirely, choosing neither to join FirstNet nor to build a broadband network on the frequencies assigned to FirstNet. 33 35 Some states may prefer to concentrate their resources on improving mission-critical voice networks and acquire broadband access from a commercial provider or through other means. FirstNet, through its partners, intends to provide service in all states, even if a state chooses not to be a customer or otherwise participate in the network. 34 36 The Spectrum Act specifies that a state that chooses to build its own Radio Access Network must submit an alternative plan for construction, operation, maintenance, and improvement of the Radio Access Network within the state. The state has 90 days to agree to participate or to notify FirstNet, the NTIA, and the FCC of its intent to deploy its own part of the Radio Access Network, and an additional 180 days to provide its plan to the FCC. 35 37 The state must demonstrate to the FCC, which the law requires to review the plan, that its planned Radio Access Network would comply with minimum technical requirements and be interoperable with FirstNet. If a state's plan is approved it will be eligible to apply for a grant, administered by the NTIA, that will be funded from the Network Construction Fund created by the act. The amount available may be less than what would have been provided if the state had opted in to the FirstNet program, because the grant will be applied only toward building the Radio Access Network and may be subject to matching grant requirements. Approval of the grant is contingent on meeting additional requirements established by the NTIA, including sustainability, timeliness, cost-effectiveness, security, coverage, and services that are comparable to FirstNet. 36 38 The state would be required to pay a user fee for access to FirstNet's core network. 37 39 It would not be permitted to enter commercial markets or lease access to its network except through a public-private partnership. FirstNet has determined that any revenue to the state from a partnership must be used only for costs associated with its participation in FirstNet. If a state's plan meets FCC and NTIA requirements, then the NTIA may approve lease authority for FirstNet to grant a sub-license to a state, to operate on some portion of the FirstNet spectrum. On July 19, 2016, the NTIA published notice of its proposal for evaluating State Alternative Plan Programs for states that wish to opt out of FirstNet. 38 40 If a state's plan has met the initial approval of the FCC, it must then demonstrate to the NTIA that it meets technical and financial requirements. To the general parameters provided in the Spectrum Act, the NTIA has added several specific criteria for states that parallel requirements for contractors, including: The State Alternative Plan Proposal submission and the related request for a spectrum lease will be treated as a single request for a grant (even though the state may choose not to request a grant as described in the Spectrum Act) in accordance with provisions of the Federal Grants and Cooperative Agreement Act of 1977 ( P.L. 95-224 ). The forthcoming Federal Funding Opportunity announcement will include additional details regarding the technical capabilities required of a state, in addition to those published in the July 19 notice. States must submit their application to the NTIA within 60 days of FCC approval of the alternative plan. State network plans must adhere to the same policies as those applied to FirstNet. States will be required to provide information on how it will manage its Radio Access Network, including, for example, its staffing plan and budget documents. States must disclose partnership agreements and address funding risks; NTIA may require surety bonds to ensure network construction is completed. Deadlines for the state plan must match those presented in FirstNet's plan for the state. A state plan that relies on new buildouts of the network ("greenfield") might not qualify as cost effective. In evaluating the cost-effectiveness of a state's alternative plan, NTIA will include as a factor its assessment of the value of cross-border economies of scale that may be lost. State and Community Network Participation The following discussion focuses on key statements from FirstNet that seem to indicate the agency's current plans for state, tribal, territorial, and local participation in the network. FirstNet may later choose to alter its plans. 39 41 FirstNet's deployment strategy reportedly will Include state-based eNodeB's in FirstNet's core services, thereby bringing the entire 20 MHz spectrum license under the full control of FirstNet and its federal contractors. 40 42 This decision, if implemented, represents a change in an earlier statement that proposes including the eNode B as part of the Radio Area Network. 41 43 Provide local area network capacity and connections as an extension of FirstNet, limiting state authority to providing fill-in capacity for some under-served areas. 42 44 Assign to FirstNet contractors the responsibility of identifying additional partners or subcontractors to act under the authority of the contractor; this might include, for example, negotiating an agreement with a local power company for access to its infrastructure. 43 45 Assign negotiations for access to existing state, local, or tribal infrastructure to contractors, to be pursued after the contract has been issued. 44 46 Extend coverage to rural areas where there is currently little or no commercial service through new, federally funded build-out to the commercial networks of partners chosen through the RFP process. 45 47 A major goal of this network design is to maximize the value of spectrum by capturing its full value, nationwide, in order to provide sufficient funding for rural coverage. 46 48 FirstNet therefore believes that allowing states to build their own RANs "potentially takes with it subscriber fees and/or excess network capacity fees that would have helped fund the FirstNet network in all other states." 47 49 Apparently not included in FirstNet's planning process is an analysis of the costs to be assumed by states as a consequence of its business plan. These costs include the continued operation and possible expansion of state and local LMR voice networks; the cost of integration of LMR and broadband infrastructure; the costs of forfeiting to FirstNet the potential economies of scale in network construction and operation; and the cost of lost opportunities for competition and innovation in wireless services at the state and local level. It remains to be seen what the winning contractor to deploy FirstNet will offer to states to offset costs that states are likely to bear in order to participate in FirstNet. Risks and Rewards FirstNet appears to be making decisions about the network design that are evolving as new information is gathered and analyzed. It claims that a federalized network is the "only solution" 48 50 that meets its goals of providing nationwide coverage, interoperability, and assured access. In the Second Notice it concludes that allowing populous states to opt out of FirstNet and build their own public safety broadband networks, monetizing the value of the 20 MHz of spectrum assigned for that purpose, will beggar their more rural neighbors who cannot so readily capture the value of excess capacity. This is a presumption of market failure that is not supported by information made public by FirstNet and is inconsistent with the many positive analyses of the economic value of small cell networks, community broadband, and the Internet of Things. 49 51 The value of economies of scale in building and operating wireless networks has long been recognized by telecommunications experts and policymakers. The FCC, for example, has modified its policies to make it easier for wireless companies to expand through mergers and acquisitions in order to benefit from scale economies. 50 52 These and related FCC decisions are based on, among other considerations, improving coverage through macro networks to customers for wireless services. When FirstNet refers to the importance of economies of scale, it is apparently referring to geographic coverage through macro networks. 51 53 The economics for small cell networks, however, enable profitability by providing economies of scope, with many different types of services to multiple customer segments in a small area. Economies are provided not through macro network coverage but by micro network capacity to accommodate many customers with different technology needs. Many wireless network experts believe that dense deployments of small cells in an area served by a single eNodeB tower will increase efficiency and reduce costs while increasing capacity to handle many different markets. 52 54 Although urbanized areas are seen by many as the primary market for expanding small cell services, the benefits may also be important in rural or remote areas. Experts suggest that, in addition to serving public safety, a rural small cell configuration could support, for example, transportation improvements, education, job search, agricultural and forestry management, new efficiencies in municipal government and services, and economic growth. 53 55 Economies of scale at the macro level may also be available in states with a low population density. A cost-effective network solution may be achieved by adjacent states combining their resources to provide coverage with eNodeBs and maximizing the utility of small cell networks at the local level. For state and local public safety agencies, maximizing the value of spectrum may be less important than achieving sufficient levels of scale and scope to meet their requirements. FirstNet refers to the need to monetize the value of its spectrum holdings to expand coverage, based on the existing commercial footprint for LTE, not the footprint of statewide or local public safety networks. It does not estimate the value to states and communities of small cell networks and the wireless component of community broadband that may be transferred to FirstNet's commercial partners. FirstNet's plans appear to capture for its own use most of the value of spectrum used to provide both coverage and capacity. This value is unknown but potentially far greater than what FirstNet can lawfully 54 56 spend on improving its network or by reducing user fees. The excess value of the spectrum and access to local markets that FirstNet is using to barter for goods and services, therefore, will in most cases go to FirstNet's contractual partners, not to the states and communities intended by the act to be the primary beneficiaries of FirstNet's actions. Economists might describe this as a monopoly surplus. Advantages of FirstNet's Comprehensive Network Strategy Advantages of a federalized network, cited by FirstNet, 55 57 include Swift execution. Adding public safety access to existing commercial LTE infrastructure provides a turn-key solution for immediate access to a potentially large number of public safety agencies, federal agencies, and others; Extension of LTE service to rural areas that currently have no commercial broadband service and might not have public safety communications coverage; Streamlined access for federal partners. Instead of negotiating with each state or regional network, federal agencies need only negotiate with FirstNet to gain immediate access to the entire network; National reach in times of emergency and assured access to federal incident commanders and officials; Economies of Scale. FirstNet requires full control of many assets in order to maximize their value throughout the network; and Sustainability. Development of small cell networks under FirstNet's control allows for most traffic to be off-loaded on to onto local networks that require minimal spectrum, freeing spectrum for customers with a higher dollar-value for FirstNet. Other Advantages A number of advantages offered by FirstNet could be available in many other governance or business models. These include Operation of core network (Evolved Packet Core) services such as enforcement of rules for interoperability and other policies and rules, operations, performance and security management, and subscriber databases; Purchasing power. Negotiated discounts for equipment through buying cooperatives; Research and development, standardization, and negotiations with standards bodies; Widespread adoption of broadband technologies to improve, enhance, and extend the effectiveness of emergency responders; and Development of best practices for cybersecurity and enforcement of network security procedures. Disadvantages of FirstNet's Comprehensive Network Strategy Some disadvantages of a federalized network might be Loss of state autonomy. States have a consultative role but many decisions rest with FirstNet. States also lose control of spectrum assets, potentially limiting their ability to develop capabilities and services that are of value to them but not to FirstNet's customers for nationwide service; Devaluation of state and federally funded investments in existing public safety communications networks. Although contractors may, after receiving a contract, negotiate with states and localities for access to their assets, the value and availability of those assets have not been openly stated in the FirstNet planning process; Displacement of local competitors by the FirstNet contractor in local and state broadband development. Smaller communities may not be able to generate sufficient business for two or more broadband service providers. To achieve financially viable programs, they might be restricted to using the incumbent (FirstNet) provider; Displacement of partners for broadband development. Desirable partners (such as a rural utility) may not be available for local projects because of contractual obligations to FirstNet; Loss of market power for state public safety customers. If fees from state and local public safety agencies are a small part of FirstNet's revenue stream, states lose some of their bargaining power in negotiating for improved services or other requests; and Increased risk through lack of diversified assets. Risks include operational risks such as a system - wide failure or cyberattack; financial risks such as monopoly pricing; competitive risks in some markets controlled by FirstNet contractors that may lead to reduced innovation; and the risk of poor management decisions with systemwide system-wide impact. State reactions in weighing risks and rewards of network participation may lead to another risk: limited participation, negating much of the intended value of FirstNet. NTIA Grant Programs The NTIA, in consultation with FirstNet, has responsibility for carrying out two grant programs: the State and Local Implementation Grant Program (SLIGP); and grants from the Network Construction Fund to states that are permitted to build their own Radio Access Networks. State and Local Implementation Grant Program The State and Local Implementation Fund was allocated $135 million 56 58 from the Public Safety Trust Fund for grants to be made available to all 56 states and territories to develop a plan on how to use a nationwide public safety broadband network to meet their emergency communications needs. The distribution of available funds among the states is established by the NTIA, which administers the State and Local Implementation Grant Program in consultation with FirstNet. The program is conceived as a matching grant program. Federal grants from the fund are not to exceed 80% of the projected cost to the state; however, the NTIA may make the decision to waive the matching funds requirement. The NTIA decided to plan for funding in two phases. Grants for both phases totaled over $116 million. Grants for the initial phase were awarded to 54 of the 56 eligible states and territories in FY2013. The state of Mississippi and the territory of the Northern Mariana Islands did not receive grants. The first phase of funding, totaling about $58 million, has helped states conduct outreach with public safety and state and local officials to determine their needs, gaps, and priorities for public safety wireless broadband and to prepare for formal consultations with FirstNet. Grants in the second phase may be used by states to collect data identifying and prioritizing where public safety broadband coverage is needed; identifying potential users and their capacity needs; detailing current providers and procurement mechanisms; and similar needs. 57 59 Reportedly, NTIA has recently decided no federal grant monies (SLIGP) can be used to explore any option other than "opt in". FirstNet itself recently asked for review of its interpretations of the Law ("second notice"), and those interpretations also tend to restrict the ability of states to explore options to build their own. It is clear NTIA does not want states doing coverage and financial modeling, even though such work would result in improved FirstNet plans for each state. 58 60 The second phase of grants, also for $58 million, was announced in 2015. Awards went to states to collect data identifying and prioritizing where coverage is needed and identifying potential users and other information to facilitate network deployment. 59 61 Network Construction Fund The Spectrum Act requires that $7 billion, reduced by the amount needed to establish FirstNet, be available for a Network Construction Fund established in the Treasury to be used by FirstNet for costs associated with building the nationwide network and for grants to states that qualify to build their own networks. 60 62 The amount to be made available for the fund has been set at $6.5 billion by FirstNet and the NTIA. The act effectively creates three types of expenditures from the Network Construction Fund but does not specify how funds would be allocated for (1) expenditures by FirstNet on construction, maintenance, and related expenses to build the nationwide network required in the act; (2) by the NTIA to make payments to states that are participating in FirstNet; and (3) by the NTIA for grants to those states that qualify to build their own Radio Access Networks. 61 63 GAO Study The Spectrum Act requires that, before the end of FY2022, the Government Accountability Office (GAO) is to recommend to Congress what actions should be taken in regard to the ending of FirstNet's authority, mandated to occur in 2027. Additionally, at the request of the Senate Committee on Commerce, Science, and Transportation, GAO has prepared an evaluation of FirstNet's organization, including business decisions contained in the request for proposal; use of commercial, federal, state, local, and tribal infrastructure in deploying the network nationwide; and financial sustainability. GAO presented preliminary findings as testimony at a Commerce Committee hearing on March 11, 2015, 62 64 and issued a final report on some of these issues on April 28, 2015. 63 65 In testimony, GAO summarized the progress FirstNet has made in meeting its responsibilities but noted that it had not put in place a number of measures that GAO considers important. Notably, GAO found that FirstNet has not fully assessed the risks associated with its planning efforts (such as conflict of interest); has not established Standards of Conduct; and is not fully evaluating the information from five "early builder" projects. 64 66 The full report expands on the information provided in testimony. The full report includes, for example, a timeline and other information regarding the development of FirstNet; more details about the "early builder" program; and some insight into FirstNet's planning process. Regarding the interaction of planning and the cost of building the network, GAO's comments include these observations: "As part of its planning and market research, FirstNet has developed a cost estimate for its public safety network that met most of the best practices against which we evaluated it." "FirstNet's cost estimate, including the assumptions it is based on, are not public because of the highly sensitive nature of the information it contains." "We did not assess FirstNet's cost estimate against all the characteristics established in our Cost Estimating and Assessment Guide. Specifically, we did not assess whether FirstNet's estimate was 'credible' or 'accurate' because the estimate and its associated documentation were deemed business sensitive." "We did not analyze the quantitative input and output of the cost model because the data included procurement sensitive information, and we would therefore be unable to report our findings in a public report." "Therefore we cannot say if the estimate is in line with the credible and accurate characteristics of our Cost Estimating and Assessment Guide." 65 67 OIG Report on FirstNet Criticism by a member of the board of FirstNet, in April 2013—regarding a lack of transparency in information provided to the Board , and other issues—led to a review of practices by the Office of Inspector General (OIG.). 66 68 The primary focus of the review had two main objectives, to determine whether the Department of Commerce (DOC) had adequate processes in place to ensure that FirstNet Board members properly filed financial disclosures and identified potential conflicts of interest; and used appropriate contracting processes and requirements. The overall finding is that some monitoring procedures were inadequate, including, for example, a finding that "FirstNet contracting practices lacked transparent award competition, sufficient oversight of hiring, adequate monitoring, and procedures to prevent erroneous costs.... " 67 69 In its review, the OIG looked at the roles of the NTIA, the DOC Office of General Counsel, and two agencies within DOC that were assigned direct responsibilities to assist FirstNet; the Bureau of the Census and NIST were asked to award and manage contracts with outside entities to provide assistance to FirstNet. The OIG did not specifically review activities of the NTIA Office of Public Safety Communications, created to assist FirstNet with administrative tasks, including staffing. The OIG review determined that nearly $11 million had been inappropriately spent, much of it going for consulting work that did not meet contractual definitions of deliverables. The OIG referred to this consulting work as "work products" and questioned the expenditures. The DOC responded that it conducted relevant contracting activities in accordance with federal procurement laws and regulations and monitored performance, and that the contracts produced "first-rate feasibility research, technical analysis, strategic planning, and outreach services from highly specialized consultants, whose work product has laid the groundwork for executing FirstNet's mission." 68 70 The OIG made recommendations to the Secretary, the General Counsel, the Chair of FirstNet, and the DOC's Senior Procurement Official regarding various procedures and responsibilities. A joint response from FirstNet, the NTIA, and the General Counsel concurred with the specific recommendations from the OIG, although not all the findings. In general, they defended their actions in the context of unique requirements and time constraints in setting up FirstNet. The OIG review covered a limited range of issues linked to oversight procedures. Although it did not go into detail, the OIG noted "inconsistent administration" 69 71 and several instances of significant time lags in the performance of DOC officials. For example, "6 months after the Board began regular meetings, senior NTIA and Office of General Counsel officials were still debating [the monitoring] of potential conflicts of interest." 70 72 OIG found that most of the lapses occurred in the year after the FirstNet board held its first official meeting in September 2012. The review observed that "neither a business plan nor a network plan were completed or delivered to FirstNet during the 1-year performance period of the contracts.... " 71 73 The OIG has established a team to audit and evaluate FirstNet activities. Additionally, it operates a fraud, waste, and abuse hotline for the Department of Commerce, which has received complaints regarding FirstNet. The OIG conducts follow-up on these complaints. 72 74 Testimony at a Senate hearing on June 21, 2016, 73 75 provided an update of OIG oversight of FirstNet activities. OIG reported ongoing improvements in implementing internal controls and risk assessment at FirstNet. Testimony highlighted several short- and long-term risks for FirstNet, such as the need for successfully managing the choice of contractor; setting competitive prices; and effective consultation with state and other authorities that are FirstNet's target customer base. Discussion of Other Provisions in the Spectrum Act to Improve Public Safety Communications Following is a discussion of other major provisions in the act that pertain to public safety communications, including provisions to improve the nation's 911 emergency call system. 74 76 Among federal agencies designated by the act to provide consultation and support are the Federal Communications Commission (FCC), the National Telecommunications and Information Administration (NTIA), the National Institute of Standards and Technology (NIST), and the Office of Emergency Communications (OEC). The FCC manages commercial and non-federal spectrum use, including spectrum allocated to public safety. The NTIA manages federal spectrum resources and, along with NIST, is an agency within the Department of Commerce. OEC is part of the Office of Cybersecurity and Communications, Department of Homeland Security. Spectrum Assignment Radio frequency spectrum is an essential resource for wireless communications. The energy in electronic telecommunications transmissions converts electro-magnetic spectrum (airwaves) into signals to deliver voice, text, and images. These signal frequencies are allocated for specific purposes, such as television broadcasting or WiFi, 75 77 and assigned to specific users through licenses. Allocating sufficient spectrum for wireless emergency communications has long been a concern for Congress. The Balanced Budget Act of 1997 ( P.L. 105-33 ), for example, directed the FCC to allocate 24 MHz of spectrum in the 700 MHz band for public safety use. 76 78 With the passage of the Spectrum Act, some existing public safety licenses in the 700 MHz band 77 79 and an additional license for commercial use (known as the D Block) 78 80 —together totaling 22 MHz—have been re-designated by Congress for a federal license for paired spectrum at 758-768 MHz and 788-798 MHz, plus guard bands at 768-769 MHz and 798-799 MHz to mitigate interference from adjacent channels. As required by the act, the initial, 10-year license to use these frequencies was assigned by the FCC to FirstNet. It is renewable for an additional 10 years, on condition that FirstNet has met its duties and obligations under the act. 79 81 A total of 34 MHz of spectrum capacity will therefore be available for public safety networks within the 700 MHz band: the 22 MHz designated for broadband, and 12 MHz allocated for narrowband communications, primarily voice. 80 82 Additionally, there are public safety networks on adjacent frequencies within the 800 MHz band. Time and technological advances may someday bring these spectrum assets together, but at present there are three distinct public safety network technologies in use or planned within the 700 MHz and 800 MHz bands. These are broadband communications at 700 MHz; interoperable narrowband communications at 700 MHz; and narrowband communications at 800 MHz. Some of the narrowband networks at 700 MHz and 800 MHz can share infrastructure and radios but older narrowband networks at 800 MHz are often not easily integrated with narrowband networks being built on 700 MHz frequencies. The act also gives the FCC the authority to " ... allow the narrowband spectrum to be used in a flexible manner, including usage for public safety broadband communications ... " subject to technical and interference protection measures. 81 83 States, therefore, might be able to convert some existing narrowband networks to broadband use in addition to service from FirstNet. The act requires that public safety users return frequencies known as the T-Band. 82 84 These are frequencies between 470 and 512 MHz allocated for television that have been made available for public safety use in 11 urban areas. 83 85 Since the transition to digital television, radio transmissions on some of these frequency assignments have experienced interference and the public safety agencies that use them are considering moving to new networks at 700 MHz. Other areas have recently invested to upgrade networks built on the T-Band frequencies and are concerned about the loss of this communications capacity. The act requires that the FCC act by February 2021 to establish a relocation plan that would free up the T-Band for reassignment through competitive bidding. Proceeds from the auctions of T-Band frequencies are to be available for grants to cover relocation costs. 84 86 There are no requirements in the law as to how the NTIA, the designated grants administrator, is to structure the grant program or determine eligible costs. The law also does not address technical complications that may arise because of adjacent commercial assignments not included in the rebanding. Some of the earliest spectrum assignments for public safety are in channels below 512 MHz. Public safety and other license-holders in designated channels below 512 MHz are required to reband their holdings to conform to an FCC mandate to improve spectrum efficiency. 85 87 This narrowbanding requirement, as it is called, requires that assigned channels be reduced from a width of 25 khz kHz to 12.5 khz kHz , thereby freeing up new spectrum capacity for public safety and other uses. The deadline to meet the narrowbanding requirement was January 1, 2013. To accommodate public safety license holders in the T-Band that now fall under requirements established in the act, the FCC has ruled to exempt them from the narrowbanding requirements. 86 88 Public Safety Trust Fund The law provides for transfers from a Public Safety Trust Fund, which is established in the Treasury by the act, to receive revenues from designated auctions of spectrum licenses. 87 89 The designated amounts are to remain available through FY2022, after which any remaining funds are to revert to the Treasury, to be used for deficit reduction. Auction proceeds are to be distributed in the following order of priority: To the NTIA, to reimburse the Treasury for funds advanced to cover the initial costs of establishing FirstNet: not to exceed $2 billion. To the State and Local Implementation Fund for a grant program: $135 million. To the Network Construction Fund for costs associated with building the nationwide network and for grants to states that qualify to build their own networks: $7 billion, reduced by the amount advanced to establish FirstNet. To NIST for public safety research: $100 million. To the Treasury for deficit reduction: $20.4 billion. To the NTIA and the National Highway Traffic Safety Administration for a grant program to improve 911 services: $115 million. To NIST for public safety research, phase two: $200 million. To the Treasury for deficit reduction: any remaining amounts from designated auction revenues. In compliance with the act, the FCC conducted two auctions in 2014-2015 (Auctions 96 and 97) that generated sufficient revenue to meet the funding requirements of the act summarized above. 88 90 FirstNet: Limit on Expenditures The act caps FirstNet's administrative expenses at $100 million in total over the first 10 years of operation. Costs attributed to oversight and audits are not included in the expense cap. 89 91 FirstNet: Fee Income and Other Revenue Congress gave FirstNet the authority to obtain grants, and to receive payment for the use of network capacity licensed to FirstNet and of network infrastructure "constructed, owned, or operated" by FirstNet. 90 92 Specifically, FirstNet is authorized to collect network user fees from public safety and secondary users 91 93 and to receive payments under leasing agreements in public-private partnerships. 92 94 These partnerships may be formed between FirstNet and a secondary user for the purpose of constructing, managing, and operating the network. The agreements may allow access to the network on a secondary basis for services other than public safety. 93 95 The act requires that these fees be sufficient each year to cover annual expenses of FirstNet to carry out required activities, 94 96 with any remaining revenue going to network construction, operation, maintenance, and improvement. 95 97 There is a prohibition on providing service directly to consumers; this does not impact the right to collect fees from a secondary user or enter into leasing agreements. 96 98 Planning Authority The Spectrum Act created FirstNet as an independent entity within the NTIA. FirstNet is required to plan for and establish an interoperable broadband network for public safety. The act requires that state and local agencies and tribal authorities have a consulting role in the development, deployment, and operation of the nationwide network. The act further provides an opportunity for states to plan and build their own Radio Access Networks within the framework of the nationwide broadband network. 97 99 Unless renewed, this authority expires in 2027. 98 100 When Congress creates an independent entity within the federal government, it may have the obligation to achieve a specific goal, usually within a specific time frame. 99 101 As an independent entity, FirstNet—the First Responder Network Authority—has been given both goals and time frames. It has been instructed by Congress to exercise all powers specifically granted by the act and "such incidental powers as shall be necessary" 100 102 to create a nationwide broadband network for public safety. The law requires FirstNet to become a self-funding entity, independent of government subsidies. 101 103 FirstNet is to take "all actions necessary to ensure the building, deployment, and operation" of the network in consultation with federal, state, tribal, and local public safety entities, the Director of NIST, the FCC, and the public safety advisory committee. 102 104 FirstNet appears therefore to be an autonomous organization, with broad powers to carry out its mandate, within the requirements established by the law. It has, for example, sole power to select the program's manager and its agents, consultants, and other experts subject to the requirement that they be chosen "in a fair, transparent, and objective manner." 103 105 However, FirstNet, except for certain exemptions provided in the act, must follow federal agency requirements, notably in hiring and procurement, slowing down the process for establishing FirstNet as a going concern. 104 106 FirstNet is headed by a board of 15 members of which 12 are appointed by the Secretary of Commerce according to criteria established by the act, which are intended to provide both representation from key stakeholders and expertise. The other three members of the board are designees of the Secretary of the Department of Homeland Security, the Attorney General of the United States, and the Director of the Office of Management and Budget. The Secretary of Commerce is required to appoint a chairman of the board for an initial term of two years. 105 107 As part of its management of the network, FirstNet is required, at a minimum To establish network policies, including development of detailed requests for proposals to build the network, and operational matters such as terms of service and billing practices. 106 108 To consult with states on network-related expenditures, as part of the preparation of policies and requests for proposals. 107 109 To enter into agreements to use existing communications infrastructure, including commercial and federal infrastructure, "to the maximum extent economically desirable." 108 110 To ensure the construction, maintenance, operation, and improvement of the broadband network, taking into account new and evolving technologies. 109 111 To enter into agreements with commercial networks to allow public safety roaming on their networks. 110 112 To represent the interests of the network's users before standards-setting boards, in consultation with NIST, the FCC, and its own Public Safety Advisory Committee. 111 113 FirstNet is required to create a public safety advisory committee to assist in carrying out its mandate. 112 114 There are no requirements in the statute as to the composition of the committee. By-laws adopted at the organizing meeting of the FirstNet Board of Directors on September 25, 2012, created a Public Safety Advisory Committee. 113 115 It was further agreed that the members of the committee would be chosen from the Advisory Committee to SAFECOM, within the Department of Homeland Security, in consultation with the Secretary of Homeland Security. The organizations chosen to be represented on the committee were announced on February 20, 2013. 114 116 State and local government interests are represented through a subcommittee of PSAC. 115 117 Statutory Obligations Examples of statutory obligations for Congress and the Administration in the direction of FirstNet include the following. Membership on FirstNet b oard . The members of the FirstNet board are to be chosen by the Secretary of Commerce, within the parameters established in the act. The Department of Homeland Security, the Attorney General, and the Office of Management and Budget each have one member on the board in permanence. The Secretary of Commerce is required to appoint a chairman of the board for an initial term of two years. 116 118 Grant p rograms for planning . The NTIA is to establish and administer the State and Local Implementation Fund. Grant provisions are to be decided in consultation with FirstNet, 117 119 but not necessarily in accordance with decisions made by the FirstNet board and executive management. Grant programs for state networks . The NTIA is to administer grants from the Network Construction Fund to states that qualify to build their own Radio Access Networks and choose to apply for a grant. 118 120 Funding for FirstNet and participating states through the Network Construction Fund. The NTIA is to determine the funding level available to each state for the buildout of the nationwide broadband network, if the state chooses to participate in FirstNet. 119 121 Spectrum leases for state networks. The NTIA sets the terms and is responsible for enforcing the requirement that states qualifying to build their Radio Access Networks must sublease spectrum through FirstNet, the assigned license-holder. 120 122 License r eview. The FCC is required to review the initial 10-year license assigned to FirstNet and consider its renewal based on performance criteria. 121 123 Performance r eview . The Government Accountability Office (GAO), within 10 years, is to prepare a report providing recommendations on "what action Congress should take" regarding the mandated termination of authority of FirstNet in 2027. 122 124 Fee schedule . The NTIA is to review and approve the annual schedule of fees charged to public safety agencies and other users for access to FirstNet's resources. 123 125 Annual audit . The Secretary of Commerce is to contract for an annual audit of FirstNet's finances and activities. The reports are to be submitted to Congress, the President, and FirstNet. 124 126 Report to Congress . FirstNet is required to submit annual reports to Congress on its "operations, activities, financial conditions, and accomplishments." 125 127 The designated appropriate congressional committees are, in the Senate, the Committee on Commerce, Science, and Transportation; in the House, the Committee on Energy and Commerce. 126 128 Time Frame The requirements of the Spectrum Act must be substantially met and the viability of the project demonstrated no later than the end of FY2022, if not sooner. The State and Local Implementation Fund and the Network Construction Fund expire in 2022, with any balances reverting to the Treasury. By 2022, GAO must have assessed the performance of FirstNet and provided a report to Congress; and the FCC must decide whether or not to renew the licenses for the public safety broadband network. Within this 10-year time frame, there are few deadlines beyond requirements for the initial establishment of the planning and implementation framework. Many of the important steps for building the network have no required deadline. Some milestones, such as rural coverage, are mandated in the act, but the deadlines are not specified. There are, for example, no deadlines in provisions that require FirstNet to Develop requests for proposals that include a requirement for timetables. 127 129 Consult with states on establishing state and local planning processes. 128 130 Complete the request for proposal process that is to be given to each state governor regarding the request for proposal and its details, and the funding level for each state as determined by the NTIA. 129 131 Mandated deadlines for states include Within 90 days of receipt of notice from FirstNet, the governor shall choose either to participate in deployment of FirstNet or to conduct its own Radio Access Network deployment within the state. 130 132 Within 180 days of giving notice to opt out of FirstNet, the governor shall complete requests for proposals for a state network. 131 133 No deadline is established in the statute for the FCC to approve or disapprove state proposals for their own portion of the nationwide broadband network. 132 134 There are also no specified deadlines for a state to apply to the NTIA for a grant to construct the Radio Access Network and to lease spectrum capacity from FirstNet, if FCC approval is received for a state network. 133 135 However, one condition of eligibility for a grant to a state to build its own Radio Access Network is that the state's plan must demonstrate "the ability to complete the project within specified comparable deadlines.... " 134 136 Next Generation 9-1-1 Today's 911 system is built on an infrastructure of analog technology that does not support many of the features that most Americans expect to be part of an emergency response. Efforts to splice newer, digital technologies onto this aging infrastructure have created points of failure where a call can be dropped or misdirected, sometimes with tragic consequences. Callers to 911, however, generally assume that the newer technologies they are using to place a call are matched by the same level of technology at the 911 call centers, known as Public Safety Answering Points (PSAPs). However, this is not always the case. To modernize the system to provide the quality of service that approaches the expectations of its users will require that the PSAPs and state, local, and possibly federal emergency communications authorities invest in new technologies. As envisioned by most stakeholders, these new technologies—collectively referred to as Next Generation 911 or NG9-1-1—should incorporate Internet Protocol standards. An IP-enabled emergency communications network that supports 911 will facilitate interoperability and system resilience; improve connections between 911 call centers; provide more robust capacity; and offer flexibility in receiving and managing calls. The same network can also serve wireless broadband communications for public safety and other emergency personnel, as well as other purposes. Recognizing the importance of providing effective 911 services, Congress has previously passed three major bills supporting improvements in the handling of 911 emergency calls. The Wireless Communications and Public Safety Act of 1999 ( P.L. 106-81) established 911 as the number to call for emergencies and gave the Federal Communications Commission (FCC) authority to regulate many aspects of the service. The most recent of these laws, the NET 911 Improvement Act of 2008 ( P.L. 110-283), required the preparation of a National Plan for migrating to an IP-enabled emergency network. Responsibility for the plan was assigned to the E-911 Implementation Coordination Office (ICO), created to meet requirements of an earlier law, the ENHANCE 911 Act of 2004 ( P.L. 108-494). Authorization for the ICO terminated on September 30, 2009. ICO was jointly administered by the National Telecommunications and Information Administration and the National Highway Traffic Safety Administration. Spectrum Act provisions re-establish the federal 9-1-1 Implementation Coordination Office (ICO) to advance planning for next-generation systems and to administer a grant program. 135 137 ICO is to provide matching grants to eligible state or local governments or tribal organizations for the implementation, operation, and migration of various types of 911 and IP-enabled emergency services, and for public safety personnel training. 136 138 States that have diverted fees collected for 911 services are not eligible for grants under the program. 137 139 Provisions in the act regarding 911 programs include GAO is required to study how states assess fees on 911 services and how those fees are used. 138 140 The General Services Administration is required to prepare a report on 911 capabilities of multi-line telephone systems in federal facilities and the FCC is to seek comment on the feasibility of improving 911 identification for calls placed through multi-line telephone systems. 139 141 The FCC is to assess the legal and regulatory environment for development of NG9-1-1 and barriers to that development, including state regulatory roadblocks. 140 142 The FCC is also to (1) initiate a proceeding to create a specialized Do-Not-Call registry for public safety answering points, and (2) to establish penalties and fines for autodialing (robocalls) and related violations. 141 143 ICO, in consultation with NHTSA and DHS , is to report on costs for requirements and specifications of NG9-1-1 services, including an analysis of costs, and assessments and analyses of technical uses. 142 144 Immunity and liability protections are provided—to the extent consistent with specified provisions of the Wireless Communications and Public Safety Act of 1999—for various users and providers of Next Generation 911 and related services, including for the release of subscriber information. 143 145 The act also requires FirstNet to promote integration of the nationwide public safety broadband network with PSAPs. 144 146 Roaming and Priority Access Within the 700 MHz Band In its National Broadband Plan , the FCC indicated that it wanted to make commercial networks in the 700 MHz band available for public safety use and requested that Congress confirm the FCC's authority to act. 145 147 The Spectrum Act provides the FCC with statutory authority to establish rules in the public interest to improve the ability of public safety networks to roam on commercial space and to gain priority access. 146 148 FirstNet is empowered by the act to enter into agreements with commercial providers that would allow public safety network users to roam on partnering networks. 147 149 The act does not state whether roaming agreements may be negotiated by states that opt out and receive spectrum leases from the NTIA to operate their own Radio Access networks. Agreements might also cover rules for priority access in times of high demand for network capacity. Priority access can take several forms, such as "ruthless pre-emption," in which non-public-safety transmissions are immediately terminated to make way for emergency communications, or negotiated priority agreements that might, for example, place public safety users at the head of the line for network access as capacity becomes available. The act stipulates that the FCC's authority may not require roaming or priority access unless (1) the public safety and commercial networks are technically compatible; (2) the commercial network is reasonably compensated; and (3) access does not preempt or otherwise terminate or degrade existing traffic on the commercial network. 148 150 Within these limits, the FCC appears to have some leeway to use its regulatory authority to support public safety in negotiations with partners. The FCC cannot, under the act, mandate ruthless pre-emption, although the act does not preclude contractual negotiations that would allow it. The act's provisions for roaming and priority access do not require a commercial vendor to make additional investments to insure technical compatibility, and the act's language might be interpreted as precluding an FCC mandate to that effect. Full-spectrum roaming is considered by many to provide advantages for public safety and also for the public at large. For example, it makes more network capacity available for shared emergency communications of all types, not just for first responders. Many believe that full-spectrum access supports competitiveness among wireless carriers—in particular assisting small wireless carriers serving rural areas to offer new broadband services—by providing access to all customers within the band. Legislation in the 115 th Congress Legislation in the 115 thCongress addressing public safety communications issues includes the following. H.R. 588(Pallone).Securing Access to Networks in Disasters Act. Directs the FCC to conduct a study on network resiliency during times of emergency. Requires the FCC to submit within three years a study on the public safety benefits and technical feasibility and cost of (1) making telecommunications service provider-owned WiFi access points, and other communications technologies operating on unlicensed spectrum, available to the general public for access to 9-1-1 services, without requiring any login credentials during times of emergency when mobile service is unavailable; (2) the provision by non-telecommunications service provider-owned WiFi access points of public access to 9-1-1 services during times of emergency when mobile service is unavailable; and (3) other alternative means of providing the public with access to 9-1-1 services during times of emergency when mobile service is unavailable. Also amends the Stafford Act to include all communications providers as essential service providers during federally declared emergencies. Introduced January 17, 2017; passed by House (voice vote) on January 23, 2017. S. 102(Cantwell).Securing Access to Networks in Disasters Act of 2017. Directs the FCC to conduct a study on alternative access to 9-1-1 services during times of emergency. Requires the FCC to submit within three years a study on the public safety benefits and technical feasibility and cost of (1) making telecommunications service provider-owned WiFi access points, and other telecommunications service provider-owned communications technologies operating on unlicensed spectrum, available to the general public for access to 9–1–1 services without requiring any login credentials during times of emergency when mobile service is unavailable; (2) the provision by non-telecommunications service provider-owned WiFi access points of public access to 9-1-1 services during times of emergency when mobile service is unavailable; and (3) other alternative means of providing the public with access to 9-1-1 services during times of emergency when mobile service is unavailable. Directs GAO to conduct a study on how executive departments can better ensure essential communications services remain operational during times of emergency; any legislative matters Congress could consider to help promote the resiliency of essential communications services; and whether a nationwide directory of points of contact among providers of essential communications services is needed to facilitate the rapid restoration of such services damaged during times of emergency. Also amends the Stafford Act to expand list of essential service providers during federally declared emergencies to include all communications providers. Introduced January 11, 2017; ordered to be reported with an amendment in the nature of a substitute favorably by the Committee on Commerce, Science, and Transportation on January 24, 2017. H.R. 582(Gohmert).Kari's Law Act of 2017. Amends the Communications Act of 1934 to require multi-line telephone systems to have a configuration that permits users to directly initiate a call to 9-1-1 without dialing any additional digit, code, prefix, or post-fix. Introduced January 17, 2017; passed by House (408-0) on January 23, 2017. S. 123(Klobuchar).Kari's Law Act of 2017. Amends the Communications Act of 1934 to require multi-line telephone systems to have a default configuration that permits users to directly initiate a call to 9-1-1 without dialing any additional digit, code, prefix, or post-fix. Ordered to be reported favorably by the Committee on Commerce, Science, and Transportation on January 24, 2017. Author Contact Information [author name scrubbed], Specialist in Science and Technology Author Contact Information [author name scrubbed], Specialist in Telecommunications Policy ( [email address scrubbed] , [phone number scrubbed]) Acknowledgments This report was originally written by [author name scrubbed], Specialist in Telecommunications Policy. Footnotes 10 . 1 . P.L. 112-96, Section 6204 (a). 2 . P.L. 112-96, Section 6202 (b) (2) (B). 3 .The spectrum license issued to FirstNet is for two 10 MHz channels of paired spectrum at 758-768 MHz and 788-798 MHz, plus guard bands at 768-769 MHz and 798-799 MHz to mitigate interference from adjacent channels. For purposes of allocation and assignment, spectrum is segmented into bands of radio frequencies measured in cycles per second, or hertz. Standard abbreviations for measuring frequencies include kHz—kilohertz or thousands of hertz; MHz—megahertz, or millions of hertz; and GHz—gigahertz, or billions of hertz. The designation can refer to an entire band, such as the 700 MHz band, or to specific frequencies within a band. 4 . P.L. 112-96, Section 6203 (c) (2). 5 .To the extent that public information is available, it appears that most if not all of the bidders are consortia of companies assembled to meet the diverse needs of the public safety network. The FirstNet RFP requires bidders to make proposals that address 16 core objectives such as cybersecurity, network reliability, and pricing. 6 .In FirstNet's Special Notice, the "Proposed Pricing Methodology, Level of Government Funding" proposes that "potential offerors may be required to propose how much of the $6.5 billion in Government funding that FirstNet will make available is needed to deploy, operate and maintain the NPSBN, based on their proposed solution given the level of value available as described in (2) below. Potential offerors would be required to propose the timing of when the funding is required to achieve the initial operating capability milestones that are detailed in the draft RFP documents." 7 . http://www.commerce.senate.gov/public/index.cfm?p=Hearings&ContentRecord_id=25dedd7c-815b-4b3d-a420-4f4324d01041&Statement_id=ec8d2396-ecd6-4787-bcc6-6c0152203066&ContentType_id=14f995b9-dfa5-407a-9d35-56cc7152a7ed&Group_id=b06c39af-e033-4cba-9221-de668ca1978a&MonthDisplay=3&YearDisplay=2015.Hearing, Senate Committee on Commerce, Science, and Transportation, "FirstNet Oversight: An Update of the Status of the Public Safety Broadband Network," June 21, 2016, testimony of Michael Poth, Chief Executive Officer, FirstNet, June 21, 2016, https://www.commerce.senate.gov/public/_cache/files/52af162c-90dd-42bb-bc1f-31b8f2d4693b/7C9C152E53812C3B20625C527735C423.mr.-poth-testimony.pdf. 8 Donny Jackson, Urgent Communications , "AT&T Is Apparent Selection to Build FirstNet, as Rivada Mercury Files Protest over Elimination from Bid," December 2, 2016, available at http://urgentcomm.com/public-safety-broadbandfirstnet/att-apparent-selection-build-firstnet-rivada-mercury-files-protest-o . 8 .National Public Safety Telecommunications Council, "Rivada Mercury Sues Over 'Wrongful Exclusion' from FirstNet Exclusion," December 4, 2017, available at https://blog.npstc.org/2016/12/04/rivada-mercury-sues-over-wrongful-exclusion-from-firstnet-procurement/. 9 .Donny Jackson, Urgent Communications, "Uncertain Delays Create Timing Issues for States, Public Safety in Preparation for FirstNet," January 10, 2017, available at http://urgentcomm.com/blog/uncertain-delays-create-timing-issues-states-public-safety-preparation-firstnet.FirstNet, Request for Information for Comprehensive Network S olution(s) ,September 17, 2014, http://www.firstnet.gov/sites/default/files/Request%20for%20Information%20for%20Comprehensive%20Network%20Solutions.pdf. 9 11 .Congressional Research Service was informed of the outline for FirstNet's comprehensive network strategy in discussion with NTIA officials between July and September 2012. 10 12 .FirstNet, Second Notice, March 9, 2015, at http://www.firstnet.gov/sites/default/files/FirstNet_Second_Public_Notice_0.pdfplus; also published in Federal Register, Vol. 80, No. 49, Friday, March 13, 2015, 1336-13351 (Docket Number 150306226-5226-01); comments due by April 28, 2015. 11 13 .FirstNet, Public Notice on Statutory Interpretations, September 17, 2014, at http://www.firstnet.gov/sites/default/files/firstnet-public-notice-middle-class-tax-relief-job-creation-act-of-2012.pdf. 12 14 .FirstNet, "Further Proposed Interpretations of Parts of the Middle Class Tax Relief and Job Creation Act of 2012," at http://www.firstnet.gov/sites/default/files/firstnet-third-notice-final-prepublication-version.pdf. 13 15 .FirstNet, Special Board Meeting Agenda, http://www.firstnet.gov/sites/default/files/FirstNet-April-24-2015-Meeting-Agenda.pdf . 14 16 ."FirstNet's Proposed Acquisition Approach," April 24, 2015, at http://www.firstnet.gov/sites/default/files/firstnet-special-notice-and-draft-rfp-documents_0.pdf. 15 17 .FirstNet, Special Noticeand supporting documents for draft RFP, Federal Business Opportunities, Solicitation Number D15PS00295, at https://www.fbo.gov/index?s=opportunity&mode=form&tab=core&id=55fa4d3227d5ac0173e4613e04368c86. 16 18 .As a federal agency, FirstNet is required to follow federal procurement processes but the act does not mandate the use of FAR. Some legal experts might argue that the contracts to be negotiated through the RFP process are not subject to FAR. For more information on FAR, see CRS Report R42826, The Federal Acquisition Regulation (FAR): Answers to Frequently Asked Questions, by [author name scrubbed], [author name scrubbed], and [author name scrubbed]. 17 19 .Fact Sheet, "FirstNet and Federal Departments and Agencies," October 2014 at http://www.firstnet.gov/sites/default/files/federal-information-fact-sheet-1.pdf. 18 20 .Ibid. 19 21 .Ibid. 20 22 .FirstNet, Request for Information for Comprehensive Network S olution(s) ,September 17, 2014, http://www.firstnet.gov/sites/default/files/Request%20for%20Information%20for%20Comprehensive%20Network%20Solutions.pdf. 21 23 ."FirstNet LTE Overview," at http://www.firstnet.gov/sites/default/files/LTE%20Overview-.pdf. The version referenced in this report is dated March 2, 2015. 22 24 .Small cells are low-powered radio access nodes that are used to boost capacity and manage network interference and connectivity. The types of small cells include Femtocells, typically used in a home; Picocells, that may serve a business; Metrocells, for urban areas; and Microcells, the largest in terms of geographic coverage, used primarily in rural areas. The term small cells is used by the Small Cell Forum as an umbrella term for operator-controlled, low-power radio access nodes using licensed or unlicensed spectrum. 23 25 .A more detailed discussion of the evolution of wireless network concepts appears in CRS Report R43595, Mobile Technology and Spectrum Policy: Innovation and Competition, by [author name scrubbed]. 24 26 . P.L. 112-96, Section 6202 (b) states that the network consists of "(1) a core network that—(A) consists of national and regional data centers, and other elements that may be distributed geographically, all of which shall be based on commercial standards; and (B) provides the connectivity between—(i) the radio access network; and (ii) the public Internet and the public switched network, or both; and (2) a radio access network that—(A) consists of all cell site equipment, antennas, and backhaul equipment, based on commercial standards, that are required to enable wireless communications, with devices using the public safety broadband spectrum; and (B) shall be developed, constructed, managed, maintained, and operated taking into account the State, local, and tribal planning and implementation grant program, under section 6302 (a)." 25 27 .In 2012, small cell deployments now commonly used by the industry to expand their LTE networks were considered experimental, for example comments in President's Council of Advisors on Science and Technology (PCAST), Reali z ing the Full Potential of Government-Held Spectrum to Spur Economic Growth, July 20, 2012, at https://www.whitehouse.gov/sites/default/files/microsites/ostp/pcast_spectrum_report_final_july_20_2012.pdf.FirstNet, Second Notice, at http://www.firstnet.gov/sites/default/files/FirstNet_Second_Public_Notice_0.pdfplus. 26 28 .Last published, March 10, 2016, https://www.dhs.gov/national-emergency-communications-plan. 27 29 .Department of Homeland Security, National Emergency Communications Plan, November 12, 2014, p .7: "… the primary means to achieve mission critical voice communications." At http://www.dhs.gov/sites/default/files/publications/2014%20National%20Emergency%20Communications%20Plan_October%2029%202014.pdf . 28 30 . P.L. 112-96, Section 6206 (c) (2) (B). 29 31 . P.L. 112-96, Section 6302 (d). 30 32 .See "Statewide Interoperability Coordinators," at http://www.dhs.gov/files/programs/gc_1286986920144.shtm. 31 33 .Hearing, House Committee on Energy and Commerce, Subcommittee on Communications and Technology, "Oversight of FirstNet and the Advancement of Public Safety Wireless Communications," testimony of Samuel Ginn, Chairman, FirstNet, November 21, 2013. List of state contacts at http://www.firstnet.gov/sites/default/files/spoc-list-directory-20150113.pdf. 32 34 . P.L. 112-96, Section 6302 (e) (1). 33 35 .A discussion of courses a state might choose appears in a blog post on medium com: Bill Schrier, "FirstNet: More Choices than Just Opt-In/out," February 7, 2015, https://medium.com/@BillSchrier/firstnet-more-choices-than-just-opt-in-out-cb47b306b62c. 34 36 .FirstNet, Second Notice, at http://www.firstnet.gov/sites/default/files/FirstNet_Second_Public_Notice_0.pdfplus. 35 37 . P.L. 112-96, Section 6302 (e) (2) and (3). 36 38 . P.L. 112-96, Section 6302 (e) (3) (D). 37 39 . P.L. 112-96, Section 6302 (f). 38 40 . Federal Register, Vol. 81, No. 138, July 19, 2016 46907 et seq., "State Alternative Plan Program (SAPP) and the First Responder Network Authority Nationwide Public Safety Broadband Network," https://www.gpo.gov/fdsys/pkg/FR-2016-07-19/pdf/2016-17034.pdf. 39 41 .The discussion is based on currently available information as of the publication date of this report. 40 42 .CRS meeting with FirstNet officials, February 13, 2015. 41 43 .FirstNet, Public Notice on Statutory Interpretations, at http://www.firstnet.gov/sites/default/files/firstnet-public-notice-middle-class-tax-relief-job-creation-act-of-2012.pdf. The Special Notice, "Terms of Reference," reiterates the proposed definition but does not provide a conclusive description of RAN. 42 44 .CRS meeting with FirstNet officials, February 13, 2015. 43 45 .Ibid. 44 46 .Hearing, Senate Committee on Commerce, Science, and Transportation, "Three Years Later: Are We Any Closer to a Nationwide Public Safety Network," March 11, 2015: oral testimony of Ms. Susan Swenson, Chairwoman, FirstNet. Ms. Swenson further explained that FirstNet had found it difficult to negotiate for access to state and local infrastructure as part of its pilot with the Los Angeles Regional Interoperable Communications System (LA-RICS). See also FirstNet, "Early Builder's Blog, February12, 2015, at http://www.firstnet.gov/newsroom/blog/early-builders-blog-la-rics. 45 47 .Ibid. 46 48 ."We believe as a general matter that Congress did not intend for a few, high density states to be able to withhold material funding for all the other States under the Act." Second Notice, op.cit. 47 49 .FirstNet, Second Notice, at http://www.firstnet.gov/sites/default/files/FirstNet_Second_Public_Notice_0.pdfplus. 48 50 .This phrase has reportedly been used in many discussions between FirstNet staff and Members of Congress or their staff. It was also used in the February 13, 2015 CRS meeting with FirstNet officials. 49 51 .Examples of sources that discuss potential value or wireless broadband for rural, suburban, and urban areas include Small Cell Forum case studies, including rural and remote areas ( http://scf.io/en/documents/047_Extending_rural_and_remote_coverage_using_small_cells.php); NTIA , Broadband USA: An Introduction to E ffective P ublic -P rivate P artnerships for B roadband I nvestments( http://scf.io/en/documents/047_Extending_rural_and_remote_coverage_using_small_cells.php);and testimony at Senate and House hearings on the Internet of Things (Senate, Committee on Commerce, Science, and Transportation, February 11, 2015; House, Committee on Energy and Commerce, March 24, 2015). 50 52 .FCC News, "FCC Announces Wireless Spectrum Cap to Sunset Effective January 1, 2003," November 8, 2001. Report and Order FCC-01-328. See Docket No. 01-14, Notice of Proposed Rulemaking, released January 23, 2001, at http://hraunfoss.fcc.gov/edocs_public/attachmatch/FCC-01-28A1.pdf. 51 53 .FirstNet, "Stakeholder Quarterly Webinar," April 2, 2015, presentation on FirstNet Second Noticeby Eli Veenendaal, Attorney-Advisor, at http://www.firstnet.gov/sites/default/files/Stakeholder_Qtrly_Webinar_20150402.pdf. 52 54 .See, for example, Qualcomm, "1000x: More Small Cells; Hyper-Dense Small Cell Deployments," June 2014. For presentation slides, see http://www.slideshare.net/qualcommwirelessevolution/web-bringing-1000x-closer-to-reality-hyper-dense-small-cells-wirelessnetworks-052014. 53 55 .See, for example, Computerworld, "Verizon Boosts Role in Farm Services and Smart Cities," by Matt Hamblen, May 1, 2015, at http://www.computerworld.com/article/2917932/internet-of-things/verizon-boosts-role-in-smart-cities-and-farms-services.html. 54 56 .The act requires FirstNet to reinvest in the network any excess receipts from the fees it is authorized to collect, P.L. 112-96, Section 6207 (b). 55 57 .These advantages were, for example, highlighted in presentations at FirstNet's "Stakeholder Quarterly Webinar," April 2, 2015 ( http://www.firstnet.gov/sites/default/files/Stakeholder_Qtrly_Webinar_20150402.pdf) as well as in other documents. 56 58 . P.L. 112-96, Section 6413. 57 59 .NTIA Press Release, "NTIA Announces Second Phase of Funding for State and Local Implementation Grant Program," March 23, 2015, http://www.ntia.doc.gov/press-release/2015/ntia-announces-second-phase-funding-state-and-local-implementation-grant-program. 58 60 .Bill Schrier, the Chief Seattle Geek Blog, "Live Long and Prosper: Impressions from the SPOCs Meeting," April 19, 2015, at https://schrier.wordpress.com/2015/04/19/live-long-and-prosper-impressions-from-the-spocs-meeting/. 59 61 .NTIA Press Release, NTIA Announces Second Phase of Funding for State and Local Implementation Grant Program," March 23, 2015, https://www.ntia.doc.gov/press-release/2015/ntia-announces-second-phase-funding-state-and-local-implementation-grant-program. 60 62 . P.L. 112-96, Section 6413. 61 63 . P.L. 112-96, Section 6206 (e). 62 64 .Hearing, Senate Committee on Commerce, Science, and Transportation, "Three Years Later: Are We Any Closer to a Nationwide Public Safety Network," March 11, 2015: Testimony of Mark L. Goldstein, Director, Physical Infrastructure Issues, GAO at http://www.commerce.senate.gov/public/?a=Files.Serve&File_id=782a6761-b54b-4e6b-918d-6bd28b287f34. 63 65 .GAO, Public-Safety Broadband Network: FirstNet Should Strengthen Internal Controls and Evaluate Lessons Learned, GAO-15-407, April 2015, at http://www.gao.gov/assets/670/669861.pdf. 64 66 .The early builder projects refer to four recipients of BTOP (Broadband Technology Opportunities Program) grants from the NTIA that also qualified for temporary sub-leases of the spectrum license held by FirstNet as well as Harris County, TX, which qualified for a license but did not receive a BTOP grant. These programs are intended to provide valuable lessons for FirstNet as it prepares to deploy nationwide. The four early builders with BTOP grants were Los Angeles County, CA (LA-RICS); Adams County, CO; New Jersey; and New Mexico. LA-RICS later withdrew. Three recipients with BTOP grants that did not qualify as early builders are Charlotte, NC; San Francisco, CA; and Mississippi. More information regarding the early builders is on the FirstNet website. Information on BTOP grant programs appears in CRS Report R41775, Background and Issues for Congressional Oversight of ARRA Broadband Awards, by [author name scrubbed]. 65 67 .GAO, Public-Safety Broadband Network: FirstNet Should Strengthen Internal Controls and Evaluate Lessons Learned, GAO-15-407, April 2015, p. 32, at http://www.gao.gov/assets/670/669861.pdf. 66 68 .OIG, First Responder Network Authority: FirstNet Must Strengthen Management of Financial Disclosures and Monitoring of Contracts, Final Report No. OIG-15-013-A, December 5, 2014, at http://www.oig.doc.gov/OIGPublications/OIG-15-013-A.pdf. 67 69 .Ibid., cover memorandum. 68 70 .Ibid., p. 36. 69 71 .Ibid., p. 5. 70 72 .Ibid., p. 6. 71 73 .Ibid., p. 12. 72 74 .Hearing, Senate Committee on Commerce, Science, and Transportation, "Three Years Later: Are We Any Closer to a Nationwide Public Safety Network," March 11, 2015: testimony of The Honorable Todd J. Zinser, Inspector General, U.S. Department of Commerce, http://www.commerce.senate.gov/public/index.cfm?p=Hearings&ContentRecord_id=25dedd7c-815b-4b3d-a420-4f4324d01041&Statement_id=ec8d2396-ecd6-4787-bcc6-6c0152203066&ContentType_id=14f995b9-dfa5-407a-9d35-56cc7152a7ed&Group_id=b06c39af-e033-4cba-9221-de668ca1978a&MonthDisplay=3&YearDisplay=2015. 73 75 .Hearing, Senate Committee on Commerce, Science, and Transportation, "FirstNet Oversight: An Update of the Status of the Public Safety Broadband Network," June 21, 2016, Testimony of Andrew Katsaros, Principal Assistant Inspector General for Audit and Evaluation, Department of Commerce, Office of Inspector General, https://www.commerce.senate.gov/public/_cache/files/efc4c1fd-6dff-4ca4-a79d-b2b4d470ee71/9013D88B9BB87AF29D2F242012682DC2.mr.-katsaros-testimony.pdf. 74 76 .The information in this and following sections has appeared in earlier versions of this report. 75 77 .WiFi, for wireless fidelity, operates on unlicensed frequencies that are not assigned to a specific owner but instead are available to support any device approved by the FCC. 76 78 .47 U.S.C. §309 (j) (14). 77 79 .763-768 MHz, 793-798 MHz, 768-769 MHz and 798-799 MHz. 78 80 .758-763 MHz and 788-793 MHz; P.L. 112-96, Section 6001, (2). 79 81 . P.L. 112-96, Section 6201. 80 82 .769-775 MHz and 799-805 MHz. 81 83 . P.L. 112-96, Section 6102. 82 84 . P.L. 112-96, Section 6103. 83 85 .Metropolitan areas: Boston, MA; Chicago, IL; Dallas/Fort Worth, TX; Houston, TX; Los Angeles, CA; Miami, FL; New York, NY/Newark NJ; Philadelphia, PA; Pittsburgh, PA; San Francisco/Oakland, CA; and Washington, DC. 84 86 .The National Public Safety Telecommunications Council (NPSTC) prepared a report that provided an overview of T-Band assignments, some of the problems created by the act's requirements, and possible alternative solutions. NPSTC, T-Band Report, March 15, 2013; link to PDF at http://www.npstc.org/, "NPSTC Releases T Band Report." 85 87 .Details at http://transition.fcc.gov/pshs/public-safety-spectrum/narrowbanding.html. 86 88 .FCC, "Waiver of Narrowbanding Deadlines for T-Band (470-512 MHz) Licenses," Docket No. WT 99-87, released April 26, 2012. 87 89 . P.L. 112-96, Section 6413. 88 90 .For additional information on the auctions, see CRS Report R44433, Framing Spectrum Policy: Legislative Initiatives, by [author name scrubbed]. 89 91 . P.L. 112-96, Section 6207 (b). 90 92 . P.L. 112-96, Section 6206 (b) (4). 91 93 . P.L. 112-96, Section 6208 (a) (1). 92 94 . P.L. 112-96, Section 6208 (a) (2). 93 95 . P.L. 112-96, Section 6208 (a) (2) (B). 94 96 . P.L. 112-96, Section 6208 (b). 95 97 . P.L. 112-96, Section 6208 (d). 96 98 . P.L. 112-96, Section 6212. 97 99 .Current information on FirstNet's activities, including network design and state planning, is available at http://www.firstnet.gov. 98 100 . P.L. 112-96, Section 6206 (f). 99 101 .For examples, see CRS Report RS22230, Congressional or Federal Charters: Overview and Enduring Issues, by [author name scrubbed]. 100 102 . P.L. 112-96, Section 6206 (a) (1). 101 103 . P.L. 112-96, Section 6208. 102 104 . P.L. 112-96, Section 6206 (b) (1). 103 105 . P.L. 112-96, Section 6205 (b) (1). 104 106 .Hearing, House Committee on Energy and Commerce, Subcommittee on Communications and Technology, "Oversight of FirstNet and the Advancement of Public Safety Wireless Communications," testimony of Samuel Ginn, Chairman, FirstNet, November 21, 2013. 105 107 . P.L. 112-96, Section 6204. 106 108 . P.L. 112-96, Section 6206 (c) (1). 107 109 . P.L. 112-96, Section 6206 (c) (2). 108 110 . P.L. 112-96, Section 6206 (c) (3). 109 111 . P.L. 112-96, Section 6206 (c) (4). 110 112 . P.L. 112-96, Section 6206 (c) (5). 111 113 . P.L. 112-96, Section 6206 (c) (7). 112 114 . P.L. 112-96, Section 6205 (a). 113 115 .Board Resolution 1, By-Laws, http://www.ntia.doc.gov/files/ntia/publications/firstnet_resolution_no._1_on_bylaws_adopted_9.25.12.pdf. 114 116 .NTIA, "FirstNet Names members of Public Safety Advisory Committee," February 20, 2013, http://www.ntia.doc.gov/press-release/2013/firstnet-names-members-public-safety-advisory-committee. 115 117 .Information on current activities of and participation in PSAC are available in the PSAC Fact Sheet, http://www.firstnet.gov/sites/default/files/PSAC%20Fact%20Sheet_050316_1.pdf. 116 118 . P.L. 112-96, Section 6204. 117 119 . P.L. 112-96, Section 6302 (a). 118 120 . P.L. 112-96, Section 6302 (e) (3) (C) (iii) (I). 119 121 . P.L. 112-96, Section 6302 (e) (1) (C). 120 122 . P.L. 112-96, Section 6302 (e) (3) (C) (iii) (II). 121 123 . P.L. 112-96, Section 6201 (b). 122 124 . P.L. 112-96, Section 6206 (g). 123 125 . P.L. 112-96, Section 6208 (c). 124 126 . P.L. 112-96, Section 6209. 125 127 . P.L. 112-96, Section 6210. 126 128 . P.L. 112-96, Section 6001 (3). 127 129 . P.L. 112-96, Section 6206, (c) (1). 128 130 . P.L. 112-96, Section 6206, (c) (2). 129 131 . P.L. 112-96, Section 6302 (e) (1). 130 132 . P.L. 112-96, Section 6302, (e) (2). 131 133 . P.L. 112-96, Section 6302, (e) (3) (B). 132 134 . P.L. 112-96, Section 6302 (e) (3) (C) (i). 133 135 . P.L. 112-96, Section 6302, (e) (3) (C) (iii). 134 136 . P.L. 112-96, Section 6302, (e) (3) (D) (i) (III). 135 137 . P.L. 112-96, Section 6503, "Section 158 "(a). 136 138 . P.L. 112-96, Section 6503, "Section 158 "(b). 137 139 . P.L. 112-96, Section 6503, "Section 158 "(c). 138 140 . P.L. 112-96, Section 6505. 139 141 . P.L. 112-96, Section 6504. 140 142 . P.L. 112-96, Section 6509. 141 143 . P.L. 112-96, Section 6507. 142 144 . P.L. 112-96, Section 6508. 143 145 . P.L. 112-96, Section 6506. 144 146 . P.L. 112-96, Section 6206 (b) (2) (C). 145 147 .FCC, Connecting America: The National Broadband Plan, http://www.broadband.gov/download-plan/. 146 148 . P.L. 112-96, Section 6211. 147 149 . P.L. 112-95, Section 6206 (c) (5). 148 150 . P.L. 112-96, Section 6211.
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(PDF) Synthesis of a Highly Efficient BiOCI Single-Crystal Nanodisk Photocatalyst with Exposing {001} Facets PDF | BiOCl is known as a highly efficient photocatalyst for degradation of pollutants. However, effective methods for fabricating BiOCl nanomaterials... | Find, read and cite all the research you need on ResearchGate Synthesis of a Highly Efficient BiOCI Single-Crystal Nanodisk Photocatalyst with Exposing {001} Facets May 2014 ACS Applied Materials & Interfaces6(10) DOI: 10.1021/am5010392 Authors: <here is a image d554ff720d5de00a-5f13fb8f9f4a6a85> Xing Zhang Anhui University <here is a image f2f62089ad6ff61c-d19572ff1996375a> Xin-Bo Wang Xin-Bo Wang <here is a image f2f62089ad6ff61c-d19572ff1996375a> Li-Wei Wang Li-Wei Wang <here is a image 463dad77f66b51b4-b602e328f059e231> Wei-Kang Wang East China Normal University Abstract and Figures BiOCl is known as a highly efficient photocatalyst for degradation of pollutants. However, effective methods for fabricating BiOCl nanomaterials with well-defined facets are still lacking. In this work, a facile synthetic method was developed for the fabrication of BiOCl nanodisks with exposed {001} facets. The central feature of this approach was the use of water as the hydrolysis agent and ethylene glycol as the crystal growth inhibitor agent to tune the growth of BiOCl nanomaterial. With this approach, the size and shape of BiOCl nanostructures could be effectively tuned through adjusting the volume ratio of ethylene glycol/H2O. In addition, the mechanism of the crystal growth in this fabrication process was elucidated. The as-prepared BiOCl nanodisks with exposed {001} facets exhibited an excellent photocatalytic activity towards Rhodamine B degradation under both ultraviolet and visible light irradiations. These findings shed light on the deep understanding of formation mechanisms of BiOCl nanodisks and provide an efficient and facile method for the synthesis of high active photocatalyst. <here is a image 91086ca98f577bb4-6e6c97753ef8829f> (a) XRD patterns of the BiOCl-N001 and BiOCl-Y001 nanodisks; (b) SEM image; (c) TEM image of the BiOCl-Y001 nanodisks; (d) TEM image of single BiOCl-Y001 nanodisk surface; (e) HRTEM image of the BiOCl-Y001 nanodisks surface and insert is the corresponding SAED; (f) the crystal structure of BiOCl of (001) orient; (g) TEM image of BiOCl nanodisk lateral; (h) HRTEM image of single BiOCl nanodisk lateral and insert is the corresponding SAED; and (i) the crystal structure of BiOCl of (100) orient. … <here is a image 7d41c9f8444736e6-71d788fe6eb7a3f6> XPS spectra of (a) survey spectrum; (b) Bi 4f; (c) O 1s; and (d) Cl 2p for BiOCl-Y001 nanodisks. … <here is a image 3b7e46a9c31672ae-7a466d1d0cf4fef1> Growth of the BiOCl nanocrystal at different reaction steps: (a) the initial of white suspension; (b) 160 °C for 1 h. … <here is a image 7ef3191d6490cfac-9bd66fe5314a8d74> UV−vis diffuse reflectance spectra of BiOCl-Y001 and BiOCl-N001 nanodisks. … <here is a image fe090f26882e512b-4fa48020ae76e889> +1 Nitrogen adsorption−desorption isotherm plot and corresponding pore-size distribution (insert) of the as-prepared BiOCl-Y001 and BiOCl-N001nanodisks. … Figures - uploaded by Xing Zhang Synthesis of a Highly E ffi cient BiOCl Single-Crystal Nanodisk Photocatalyst with Exposing {001} Facets Xing Zhang, † , ‡ Xin-Bo Wang, † Li-Wei Wang, † Wei-Kang Wang, † Lu − Lu Long, † Wen-Wei Li, † and Han-Qing Yu * , † , ‡ † Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China ‡ Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui, China * S Supporting Information ABSTRACT: BiOCl is known as a highly e ffi cient photo- catalyst for degradation of pollutants. However, e ffective methods for fabricating BiOCl nanomaterials with well-de fined facets are still lacking. In this work, a facile synthetic method was developed for the fabrication of BiOCl nanodisks with exposed {001} facets. The central feature of this approach was the use of water as the hydrolysis agent and ethylene glycol as the crystal growth inhibitor agent to tune the growth of BiOCl nanomaterial. With this approach, the size and shape of BiOCl nanostructures could be e ff ectively tuned through adjusting the volume ratio of ethylene glycol/H 2 O. In addition,the mechanism of the crystal growth in this fabrication process was elucidated. The as-prepared BiOCl nanodisks with exposed {001} facets exhibited an excellent photocatalytic activity towards Rhodamine B degradation under both ultraviolet and visible light irradiations. These fi ndings shed light on the deep understanding of formation mechanisms of BiOCl nanodisks and provide an e ffi cient and facile method for the synthesis of high active photocatalyst. KEYWORDS: BiOCl, degradation, facets, nanodisk, photocatalysis, visible light ■ INTRODUCTION Layered materials, such as graphene, 1 are promising materials for sensing, 2 catalysis, 3 manufacturing device, 4,5 solid-state lubricant, 6 and energy storage applications. 7 These materials possess two-dimensional (2D) crystals structure, high speci fic surface areas, and large fraction of uncoordinated surface atoms relative to the corresponding bulks. In parallel with the development of graphene-like materials, a complex ternary layer compound, BiOCl, has also been extensively investigated for one decade. 8 − 12 Recently, a facet-controlled fabrication of single-crystalline BiOCl semiconductors with well-de fi ned morphology is attracting great interests. 12 −17 It was found that the photocatalytic activity of these materials depended sensitively on the exposed surfaces with distinct crystal facets. A comparison among the photocatalytic activities of the BiOCl single-crystalline nanosheets withdi ff erent exposed facets shows that the nanosheets with exposed {001} facets exhibited a higher activity for direct semiconductor photoexcitation degradation of pollutants under UV irradiation, but their counterpart with exposed {010} facets possessed a superior activity for indirect dye photosensitization degradation of pollutants under visible light irradiation. 12 In addition, it was demonstrated that ultrathin BiOCl nanosheets of {001} facets with an atomic-scale thickness for the increased surface vacancy associate possessed an enhanced adsorption capability and enabled e ff ective separation of the electron-hole pairs. 16 Density functional theory calculations on the photocatalytic properties of BiOCl nanosheets with {001}, {110}, and {010} facets con fi rm that X-terminated (X = F, Cl, Br, and I) bulk-like {001} facets with clear boundary of [Bi 2 O 2 ] and halogen slabs had a high thermodynamic stability and e ffi cient separation of photo-induced e − − h +pairs. 18,19 However, since Bi 3+ ions are liable to hydrolysis in water solution, the synthesis of BiOCl nanostructure is usually conducted in solvent system, such as ethylene glycol (EG), diethylene glycol, triethylene glycol, 20 −22 or in acid-assisted water system (e.g., citric acid and hydrochloric acid). 23 −27 In these systems, three dimensional microspheres are usually obtained. For these microsphere morphologies, contaminants adsorbed on their surface reduce their catalytic activity. Thus, synthetic methods of highly active BiOCl catalysts are greatly needed. As aforementioned, 2D BiOCl nanomaterial with {001} facets has a high catalytic activity and layer-structured BiOCl could be readily grown into 2D nanostructure because of the inherent crystal growth tendency in water system. However, controlling of the hydrolysis of Bi 3+ ions in water systems and obtaining uniform, well dispersed and high-purity 2D BiOCl are the main problem to be resolved. Therefore, Received: February 19, 2014 Accepted: April 30, 2014 Published: May 5, 2014 Research Article www.acsami.org © 2014 American Chemical Society 7766 dx.doi.org/10.1021/am5010392 | ACS Appl. Mater. Interfaces 2014, 6, 7766 −7772 e ff ective methods for controlled synthesis of 2D BiOCl nanomaterials with {001} facets are highly desired. In this work, in order to resolve the Bi 3+ hydrolysis problem in water system and synthesize uniform and high-purity 2D BiOCl nanodisks with exposed {001} facets, we proposed a new facile approach through combining organic solvent and water, elucidated their formation mechanism in terms of crystal growth tendency, and demonstrated their high photocatalytic activity for pollutant degradation. ■ EXPERIMENTAL SECTION Preparation of the 2D BiOCl-Y001 Nanodisks. All chemicals used in this work were of analytical grade and purchased from Shanghai Chemical Reagent Co., China. In a typical procedure of the nanodisks preparation, 0.972 g Bi(NO 3 ) 3 · 5H 2 O (2 mmol) was added into 15 mL EG. Under vigorous stirring and sonication for 10 min, the mixture was dispersed to form a homogeneous solution. In parallel, 0.541 g FeCl 3 · 6H 2 O (2 mmol) was added into 15 mL distilled water under vigorous stirring for 5 min to form a homogeneous solution. Then, the above two solutions were mixed, and a white suspension was formed immediately. The white suspension was transferred into a 50 mL autoclave with a Te fl on linear, which was heated at 160 ° C for 12 h, and then naturally cooled to ambient temperature. The resulting solid powders were collected through centrifugation and washed with distilled water and absolute alcohol for several times to remove residual ions. The fi nal products were then dried at 70 ° C for 6 h prior to characterization. Physicochemical Characterization of the Samples. The X-ray powder di ff raction (XRD) patterns of the samples were obtained on a Philips X ’ Pert PRO SUPER di ff ractometer equipped with graphite monochromatized Cu K α radiation ( λ = 1.541874 Å). The scanning electron microscopy (SEM) images of the samples were taken with an X-650 scanning electron micro analyzer and a JSM-6700F field emission SEM (JEOL Co., Japan). The transmission electron microscopy (TEM) images of the samples were recorded on a TEM (H-7650, Hitachi Co., Japan), using an electron kinetic energy of 100 kV. The high-resolution transmission electron microscopy (HRTEM) images and selected area electron di ff raction (SAED) patterns were taken on an HRTEM (2010, JEOL Co., Japan) at an acceleration voltage of 200 kV. The chemical compositions and the valence states of constituent elements were analyzed by X-ray photoelectron spectroscopy (XPS) (ESCALAB250, Thermo Fisher Inc., U.S.A.). The di ff use re fl ectance spectra (DRS) were measured using a UV/Vis spectrophotometer (Solid 3700, Shimadzu Co., Japan). The surface area was measured by the Brunauer − Emmett− Teller (BET) method with a Builder 4200 instrument (Tristar II 3020M, Micromeritics Co., U.S.A.). Photocatalytic Measurements. The photocatalytic activity of the BiOCl nanodisks for the degradation of Rhodamine B (RhB) was evaluated using a UV light ( λ = 254 nm) or 350 W Xe arc lamp with a 420 nm cuto fffi lter as the light source at ambient temperature. Before the tests, 0.02 g of BiOCl nanodisks as a photocatalyst was added into 30 mL aqueous solution containing 20 mg L − 1 RhB, and stirred in dark for 30 min to ensure su ffi cient adsorption/desorption equilibrium. Then, under light irradiation and continuously magnetic stirring, samples were collected at given time intervals and the RhB concentration was measured with a UV − vis spectrometer (U-3310, Hitachi Co., Japan). ■ RESULTS AND DISCUSSION Morphology and Microstructure of the BiOCl Nano- disks. Figure 1a shows the XRD patterns of the prepared BiOCl samples. The main di ff raction peaks were identical to those of the tetragonal phase BiOCl (JCPDS card no. 06- 0249). The (001) peak was much higher than the standard card, implying that the exposed surfaces of sample consisted of Figure 1. (a) XRD patterns of the BiOCl-N001 and BiOCl-Y001 nanodisks; (b) SEM image; (c) TEM imageof the BiOCl-Y001 nanodisks; (d) TEM image of single BiOCl-Y001 nanodisk surface; (e) HRTEM image of the BiOCl-Y001 nanodisks surface and insert is the corresponding SAED; (f) the crystal structure of BiOCl of (001) orient; (g) TEM image of BiOCl nanodisk lateral; (h) HRTEM image of single BiOCl nanodisk lateral and insert is the corresponding SAED; and (i) the crystal structure of BiOCl of (100) orient. ACS Applied Materials & Interfaces Research Article dx.doi.org/10.1021/am5010392 | ACS Appl. Mater. Interfaces 2014, 6, 7766 − 7772 7767 {001} facets (denote as BiOCl-Y001). The SEM images (Figure 1b) reveals that the sample possessed large-scale disk- like structures with diameter of 100 − 300 nm and thicknesses of 15 − 30 nm. The TEM images (Figure 1c) further con fi rms such a disk-like structure. The HRTEM image (Figure 1e), which was taken from the edge of the single nanodisk in Figure 1d, reveals a highly crystalline and clear lattice fringes projected along the [001] axis. The continuous lattice fringes with an interplanar lattice spacing of 0.27 nm and an angle of 90 ° matched well with the (110) atomic planes of the tetragonal BiOCl. The corresponding SAED pattern (insert in Figure 1e) indicates a single-crystalline nature of the BiOCl-Y001 nanodisk. The angle labelled in the SAED pattern was 45 °, which is in agreement with the theoretical calculation of the angle between the (110) and (200) planes. The set of di ff raction spots can be indexed as the [001] zone axis of tetragonal BiOCl. Figure 1f shows the BiOCl [001] projection crystal structure. The HRTEM image (Figure 1h), which was taken from the tip of the single nanodisk in Figure 1g, also reveals a high crystallinity of the sample. The continuous lattice fringes with an interplanar lattice spacing of ∼ 0.34 nm matched well with the (101) atomic planes of the tetragonal BiOCl. The corresponding SAED pattern (insert in Figure 1h) also con fi rms the presence of single-crystalline BiOCl nanodisk. The angle labelled in the SAED pattern was 27 ° , which is in agreement with the theoretical calculation of the angle between the (101) and (200) planes. The set of di ff raction spots could be indexed as the [010] zone axis of tetragonal BiOCl. Figure 1i shows the BiOCl [100] projection crystal structure. XPS analysis was performed to explore the surface compositions and chemical states of the as-prepared BiOCl- Y001 nanodisks. From the full scan spectrum shown in Figure 2a, the peaks of Bi, O, Cl, and C elements could be identi fied. The XPS spectra were corrected for specimen charging by referencing the C 1s peak at 284.60 eV. The Bi 4f XPS spectrum (Figure 2b) shows two main peaks with binding energies at 157.4 and 162.8 eV, corresponding to Bi 4f 7/2 and Bi 4f 5/2 of Bi 3+ , respectively. The O 1s core level spectrum (Figure 2c) could be fi tted well with the peak at 528.3 eV, which belongs to O 2 − from a bismuth − oxygen bond in BiOCl. The Cl 2p XPS spectrum shows two major peaks with binding energies at 196.2 and 197.8 eV, corresponding to Cl 2p 3/2 and Cl 2p 1/2 of Cl ‑ , respectively (Figure 2d). 21,26 All the above results demonstrate that the formed nanostructures were composed of BiOCl. Formation Mechanism of BiOCl Nanodisks and Key Factors Involved. In order to elucidate the formation mechanism of BiOCl nanodisks, the growth process was studied by analyzing the XRD patterns and SEM images of the products at various reaction stages. As shown in Figure 1a and Supporting Information (SI) Figure S1, the (001) di ffraction peak was enhanced over time, indicating that the BiOCl was formed under ambient temperature. Figure 3a illustrates the SEM image of the sample at the initial reaction stage, from which only a plate-like BiOCl nanocrystal was observed. The plate-like BiOCl nanocrystals were irregular and agminated with a size of 100 − 200 nm. Figure 3b shows that BiOCl nanocrystals with disk-like structure and good dispersion were formed (denoted as BiOCl-N001) after 1-h reaction, and the size of the BiOCl-N001 nanodisks was ∼ 200 − 300 nm. The gradual increase in BiOCl size was an Ostwald ripening process. After 3-h reaction, the morphology of the BiOCl nanocrystals was still disk-like (SI Figure S2). These results imply that the BiOCl structure was inter-grown with [Bi 2 O 2 ] slabs interleaved by double slabs of Cl atoms. This could be used to explain why the oxyhalide compounds could easily form2D laminar structure. Our results are di ff erent from the reports using organic solvent method only, with which three-dimensional micro- spheres were usually obtained. 20 Such a di ff erence might be attributed to the only existence of EG solvent in their study, which acted as a crystal growth inhibitor. As a consequence, the lamellar crystals easily generated curvature and were developed into fl ower-like morphology. 10,28,29 On the other hand, with the dose of water in our study, the crystal growth inhibitory e ffect of EG became diminished, so that the growth of the microstructure was turned into 2D laminar structure with well dispersion, rather than three-dimensional microspheres. To validate the above assumption, comparative experiments were carried out and the resulting morphologies were observed by SEM. Without the dose of water, the product was almost entirely composed of a large quantity of uniform BiOCl microspheres with an average diameter of ∼ 1 μ m (Figure 4a). The microspheres had fl owerlike shapes, which were organized from numerous thin nanoplates with a thickness of ∼ 24 nm in an interwoven arrangement. However, when the volume ratio of EG/H 2 O was decreased to 28:2, microplates (Figure 4b) with a diameter of ∼ 1 μ m were formed, which were self- assembled by nanoplates with a thickness of ∼ 20 nm (insert in Figure 2. XPS spectra of (a) survey spectrum; (b) Bi 4f; (c) O 1s; and (d) Cl 2p for BiOCl-Y001 nanodisks. Figure 3. Growth of the BiOCl nanocrystal at di ff erent reaction steps: (a) the initial of white suspension; (b) 160 ° C for 1 h. ACS Applied Materials & Interfaces Research Article dx.doi.org/10.1021/am5010392 | ACS Appl. Mater. Interfaces 2014, 6, 7766 − 7772 7768 Figure 4b). With a further decrease in volume ratio of EG/H 2O to 20:10, the products were almost all nanoplates with a size of ∼ 100 nm and a thickness of ∼ 20 nm (SI Figure S3). When the volume ratio of EG/H 2 O was decreased to 0:30, the sample exhibited large-scale plate-like structures with a diameter of 200 − 5000 nm (SI Figure S4). These results demonstrate that the morphologies of BiOCl could be e ff ectively tuned by adjusting the volume ratio of EG/H 2 O. Additional experiments were conducted in order to examine whether the metal ions also played an important role in controlling the size and shape growth of BiOCl nanomaterials. The corresponding products were examined by XRD and SEM, as shown in Figure 5 and SI Figure S5. All the products were obtained under the same conditions as detailed above. When 3 mmol CoCl 2 , NiCl 2 , and ZnCl 2 were used to replace the FeCl 3, with the other constant conditions, the size of the synthesized 2D square nanoplates was about 500 nm (Figure 5a − c). When 3 mmol SnCl 2 was used instead, the dominant products were 2D microplates with a size of 1 − 15 μ m (Figure 5d). The corresponding XRD patterns in SI Figure S5 indicate that all the 2D BiOCl nanostructures were (001) planes orient. These results show that the species of metal ions also contributed to the tuning of the BiOCl size and shape but did not a ff ect the 2D plate-like structure. The formation mechanism of the BiOCl-Y001 nanodisks is illustrated in Scheme 1a: (1) rapid nucleation at the initial stage; (2) nucleation growth into the plate-like BiOCl nanocrystals; and (3) Ostwald ripening growth of the plate- like BiOCl nanocrystal into the 2D BiOCl nanodisks. The size and shape of BiOCl could be tuned through adjusting the volume ratio of EG/H 2 O and changing the metal chlorides, as illustrated in Scheme 1b. Furthermore, application of this approach to the synthesis of other Bi-based oxyhalides was also demonstrated. In the presence of 6 mmol KBr or KI, 2D square-like BiOBr and BiOI with a diameter in micrometer scale were formed (Figure 6a, b). This result shows that the mixed-solvent system used in this study was e ff ective for the synthesis of 2D Bi-based oxyhalides nanostructures. Therefore, an e ffi cient and facile approach for the synthesis of 2D bismuth oxyhalide nanomatrials with exposed {001} facets was established. Optical Absorption Properties and BET Surface Areas of the BiOCl Nanodisks. The photocatalytic activity of a semiconductor is closely related to its energy band structure feature. Figure 7 shows the UV − vis di ff use re fl ectance spectra of the BiOCl-Y001 and BiOCl-N001 nanodisks. It is known that the optical absorption of a crystalline indirect semi- conductor near the band edge follows the formula ( α h ν ) 1/2 = B ( h ν − E g ), where α , h ν , E g , and B are the absorption coe ffi cient, photon energy, b and gap and a constant, respectively. 21 The absorption edges of the BiOCl-Y001 and BiOCl-N001 nanodisks are 399 and 377 nm and the estimated band gap energies of the as-obtained were about 3.11 and 3.29 eV from the absorption onsets, respectively. The results indicate that the BiOCl-Y001 had a narrower band gap, which might be attributed to its morphology, size, and speci fic structure. The BET speci fi c surface area of the synthesized BiOCl nanodisks was evaluated using the nitrogen adsorption- Figure 4. SEM images of the BiOCl prepared at 160 ° C for 12 h in di ff erent volume ratios of EG/H 2 O: (a) 30:0; (b) 28:2. Figure 5. SEM images of the BiOCl samples grown from the metal chloride solutions: (a) CoCl 2 ; (b) NiCl 2; (c) ZnCl 2; (d) SnCl 2. Scheme 1. Tuning Size and Shape of BiOCl Figure 6. SEM images of the samples: (a) BiOBr; (b) BiOI. ACS Applied Materials & Interfaces Research Article dx.doi.org/10.1021/am5010392 | ACS Appl. Mater. Interfaces 2014, 6, 7766 − 7772 7769 desorption method. The nitrogen adsorption-desorption isotherms of the BiOCl-Y001 and BiOCl-N001nanodisk are illustrated in Figure 8, whereas the corresponding pore-size distributions are shown in the insets of Figure 8. The BET surface areas of the BiOCl-Y001 and BiOCl-N001nanodisks calculated from the results of N 2 adsorption were 7.6 and 8.0 m 2 /g, respectively. The BiOCl-Y001 nanodisks had a smaller surface area than the BiOCl-N001 nanodisks. Photocatalytic Activity of the BiOCl Nanodisks. To explore the photocatalytic capacity of the BiOCl nanodisks and identify the relationship between the exposed crystallographic facets and the photocatalytic activity, utilization of both the prepared BiOCl-Y001 and BiOCl-N001 nanodisks for the photocatalytic degradation of RhB as the target pollutant was tested. The RhB evolution of UV − vis spectra over time with the BiOCl-Y001 nanodisks is illustrated in Figure 9a. The intensity of absorption peak at 552 nm decreased drastically over time, and completely disappeared after 120 min. To explore the photocatalytic activity of the nanodisks with {001} facets, a direct photolysis of RhB by the BiOCl-N001 nanodisks was tested under identical conditions. Figure 9b displays the temporal evolution of the spectra in the photodegradation of RhB under UV light irradiation, whereas Figure 9c shows the variation in RhB concentrations (C/C 0 )withdi ff erent photocatalysts over time. It was observed that the RhB concentration remained unchanged over time in the absence of catalysts, while the photocatalytic degradation e ffi ciency after 120 min was only 60% for the BiOCl-N001 nanodisks, indicating that the BiOCl-Y001 nanodisks exhibited a higher photocatalytic activity compared to the BiOCl-N001 nanodisks. The photocatalytic degradation of dyes on semiconductors can be achieved through direct semiconductor photoexcitation or indirect dye photosensitization. These two photocatalytic pathways respond di ff erently to light with di ff erent wave- lengths. To fi nd out the photocatalytic pathway here, the RhB degradation performance by both the BiOCl-Y001 and BiOCl- N001 nanodisks under visible light irradiation was also investigated. As shown in Figure 9d and e, the photocatalytic reactivity of the BiOCl-Y001 nanodisks was much higher than that of the BiOCl-N001 nanodisks under visible light irradiation. To evaluate the {001} facets stability of BiOCl-Y001 nanodisks after degradation of RhB under UV light and visible light irradiations, cycle experiments of the photocatalyst were conducted. The photocatalyst samples after the cycle experi- ments were disk-like structure (SI Figure S6a and d). The HRTEM images in SI Figure S6b and e display a highly crystalline and clear lattice fringes projected along the [001] axis. The continuous lattice fringes with an interplanar lattice spacing of 0.27 nm and an angle of 90 ° matched the (110) atomic planes of the tetragonal BiOCl well. The corresponding SAED patterns in SI Figure S6c and f indicate that the single- crystalline nature of the BiOCl-Y001 nanodisk was maintained after the recycle experiments. The angle labelled in the SAED pattern is 45 ° , which is in agreement with the theoretical calculation of the angle between the (110) and (200) planes. All these results show that there was no obvious change in the tetragonal phase of the BiOCl-Y001 nanodisks after photo- catalytic degradation of RhB under UV and visible light irradiations. Figure 7. UV − vis di ff use re fl ectance spectra of BiOCl-Y001 and BiOCl-N001 nanodisks. Figure 8. Nitrogen adsorption − desorption isotherm plot and corresponding pore-size distribution (insert) of the as-prepared BiOCl-Y001 and BiOCl-N001nanodisks. Figure 9. (a, b) Photodecomposition of RhB with the BiOCl samples under UV irradiation; (d, e) photodecomposition of RhB with the BiOCl samples under visible light irradiation; (c, f) comparison of photodecomposition of RhB vs time by the BiOCl-Y001 nanodisks and the BiOCl-N001 nanodisks under UV and visible light irradiation. ACS Applied Materials & Interfaces Research Article dx.doi.org/10.1021/am5010392 | ACS Appl. Mater. Interfaces 2014, 6, 7766 − 7772 7770 On the basis of the above results, both direct semiconductor photoexcitation and indirect dye photosensitization were catalyzed by the BiOCl-Y001 nanodisks. Interestingly, although the BiOCl-Y001 nanodisks had a smaller speci fi c surface area (7.6 m 2 /g) less than the BiOCl-N001 nanodisks (8.0 m 2/g), their overall activity for RhB photodegradation was higher than that of the latter, suggesting that the overall photocatalytic activity of the BiOCl nanodisks is more directly related to their surface structure rather than the speci fi c surface area. 30 The self-induced internal electric fi elds of the 2D nanostructure could induce more e ffi cient photoinduced charge separation and transfer along the [001] direction in the BiOCl-Y001 nanodisks than the BiOCl-N001 nanodisks. 12,31,32 The BiOCl- Y001 nanodisks could prevent the recombination of photo- generated electron − hole pairs to increase the photocatalytic degradation of RhB. Therefore, a synergistic e ff ect between the surface properties and suitable internal electric fi elds might be responsible for the higher photoreactivity of the BiOCl-Y001 nanodisks for both direct photoexcitation under ultraviolet light and indirect dye photosensitization degradation of RhB under visible light irradiation. ■ CONCLUSIONS In this work, BiOCl nanodisks with exposed (001) were synthesized by using a new facile approach with a mixture of solvent EG and water. A variation of the EG/water volume ratio or the type of metal ions could be used to tune the shapes of BiOCl nanostructure. The formation of the BiOCl-Y001 nanodisks was a three-step process: the rapid nucleation at the initial stage and later growth into plate-like nanocrystals, followed by the Ostwald ripening growth of the plate-like BiOCl nanocrystals into the 2D BiOCl nanostructures. The prepared BiOCl-Y001 nanodisks exhibited a higher photo- catalytic activity than the BiOCl-N001 nanodisks for both direct photoexcitation under ultraviolet light and indirect dye photosensitization degradation of RhB under visible light irradiation. These fi ndings shed light on the BiOCl growth process and also might provide an e ffi cient method for synthesizing other highly e ffi cient nano-sized photocatalysts. ■ ASSOCIATED CONTENT * S Supporting Information XRD patterns of the BiOCl samples; SEM image of the BiOCl samples prepared at the volume EG/H 2 O ratios of 20:10 and 0:30; TEM image of the BiOCl samples which were obtained after being heated at 160 ° C for 3 h. HRTEM images of BiOCl- Y001 nanodisks after the recycle experiments under UV light and visible light irradiations. This material is available free of charge via the Internet at http://pubs.acs.org/. ■ AUTHOR INFORMATION Corresponding Author * Fax: +86-551-63601592. E-mail: [email protected]. Notes The authors declare no competing fi nancial interest. ■ ACKNOWLEDGMENTS This work is supported by the National Basic Research Program of China (2011CB933700) and the Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education of China and the Open Project of State Key Laboratory of Urban Water Resource and Environment (No. QA201402). ■ REFERENCES (1) Novoselov, K. S.; Geim, A. K.; Morozov, S.; Jiang, D.; Zhang, Y.; Dubonos, S.; Grigorieva, I.; Firsov,A. Electric Field Effect in Atomically Thin Carbon Films. Science 2004 , 306 , 666 −669. (2) Li, H.; Yin, Z.; He, Q.; Li, H.; Huang, X.; Lu, G.; Fam, D. W. H.; Tok, A. I. Y.; Zhang, Q.; Zhang, H. Fabrication of Single-and Multilayer MoS 2 Film-Based Field-Effect Transistors for Sensing NO at Room Temperature. Small 2012 , 8 ,63 − 67. (3) Li, Y.; Wang, H.; Xie, L.; Liang, Y.; Hong, G.; Dai, H. MoS 2 Nanoparticles Grown on Graphene: An Advanced Catalyst for the Hydrogen Evolution Reaction. 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(31) Zhang, X.; Ai, Z.; Jia, F.; Zhang, L. Generalized One-Pot Synthesis, Characterization, and Photocatalytic Activity of Hierarchical BiOX (X = Cl, Br, I) Nanoplate Microspheres. J. Phys. Chem. C 2008, 112 , 747 −753. (32) Xiao, X.; Liu, C.; Hu, R.; Zuo, X.; Nan, J.; Li, L.; Wang, L. Oxygen-Rich Bismuth Oxyhalides: Generalized One-Pot Synthesis, Band Structures and Visible-Light Photocatalytic Properties. J. Mater. Chem. 2012 , 22 , 22840 −22843. ACS Applied Materials & Interfaces Research Article dx.doi.org/10.1021/am5010392 | ACS Appl. Mater. Interfaces 2014, 6, 7766 − 7772 7772 ... No impurities peaks were observed, suggesting that the as-synthesized products are phase-pure BiOCl, which is consistent with X-ray photoelectron (XPS) survey spectrum analysis (Fig. S2a), and particularly, the absence of the N1s signal ruled out the presence of any PVP residues on the surfaces of BiOCl-SP (Fig. S2b). Interestingly, relatively intense [001] peaks reflect a preferred orientation of BiOCl-SP along [001] direction, and overall wider peaks point to the restricted crystalline size [13, 35] . Detailed examination revealed that the peak belonging to the (001) plane shifted to a lower 2 value, whereas the peak corresponding to the (002), (101), (003), and (104) plane shifted to a higher 2 value (Fig. S3), collaboratively indicating the reorganizations of stacked assembly in BiOCl. ... ... Further, we effort to purpose a pits-induced photocatalytic mechanism over BiOCl-SP. Notably, the basic plane facets (001) in BiOCl photocatalysts, typically tend to receive electrons because of their relatively higher work function, as demonstrated by our density functional theory calculations (DFT and Fig. S34) [20, 35, 46,47]. Herein, the pits are induced on the (001) facets of BiOCl-SP, because of which multiple underlying lateral facets get exposed, which may create shorter diffusion pathways and thus channelize the photoexcited electrons and holes to reach faster at (001) surfaces. ... The Synergy of Active Sites Induced by Surface Pits in Biocl Nanoplates for Efficient Co2 Photoreduction <here is a image a68cec94f46a37d9-05c959fad62d9bd9> Malik Zeeshan Shahid Rashid Mehmood Song Zheng Zhengquan Li ... In recent years, chemical methods based photocatalysis and advanced photocatalysis have become appropriate methods with great capability including environmental production, complete degradation of pollutants and no secondary pollution occur for the removal of organic pollutants Prasad et al., 2020). In this regard, metal oxide, metal sulphide and metal nanoparticles are the good choice of candidate for the removal of organic pollutants (Bhuvaneswari et al., 2021;Lu et al., 2018; Zhang et al., 2014) . Especially, metal oxides such as ZnO and TiO 2 are the most important semiconductor materials for the removal of organic pollutants due to their wide band gap (3.2 eV). ... <here is a image 4b4894070f74e7a7-de0a964e7cf50ec5> Paramsivam Shanmugam <here is a image f45756665582003b-1ebf97094414ff52> Siwaporn Meejoo Smith <here is a image 7a8f998f2731a9d2-1d598179419ab84b> Supakorn Boonyuen <here is a image b2fb6db90a8bd262-84f801f89a4acc65> Apanee Luengnaruemitchai In this study, versatile boron-doped graphitic carbon nitride (gCN) incorporated mesoporous SBA-15 (BGS) composite materials were prepared by thermal polycondensation method using boric acid & melamine as a B-gCN source material and SBA-15 as mesoporous support. The prepared BGS composites are utilized sustainably using solar light as the energy source for the continuous flow of photodegradation of tetracycline (TC) antibiotics. This work highlights that the photocatalysts preparation was carried out with an eco-friendly strategy, solvent-free and without additional reagents. To alter the amount of boron quantity (0.124 g, 0.248 g, and 0.49 g) have to prepare three different composites using a similar procedure, the obtained composites viz., BGS-1, BGS-2 and BGS-3, respectively. The physicochemical property of the prepared composites was investigated by X-ray diffractometry, Fourier-transform infrared spectroscopy, Raman, Diffraction reflectance spectra, Photoluminescence, Brunauer-Emmett-Teller and transmission electron microscopy (TEM). The results shows that 0.24 g boron loaded BGS composites degrade TC up to 93.74%, which is much higher than the rest of the catalyst. The addition of mesoporous SBA-15 incresed the specific surface area of the g-CN, and heteroatom of boron increased the interplanar stracking distance of g-CN, enlarged the optical absorption range, reducing the energy bandgap and enhanced the photocatalytic activity of TC. Additionally, the stability and recycling efficiency of the representative photocatalysts viz., BGS-2 was observed to be good even at the fifth cycle. The photocatalytic process using the BGS composites demonstrated to be capable candidate for the removal of tetracycline biowaste from aquesous media.
https://www.researchgate.net/publication/262074549_Synthesis_of_a_Highly_Efficient_BiOCI_Single-Crystal_Nanodisk_Photocatalyst_with_Exposing_001_Facets
FIS-RGSO: Dynamic Fuzzy Inference System Based Reverse Glowworm Swarm Optimization of energy and coverage in green mobile wireless sensor networks | Request PDF Request PDF | FIS-RGSO: Dynamic Fuzzy Inference System Based Reverse Glowworm Swarm Optimization of energy and coverage in green mobile wireless sensor networks | In mobile wireless sensor networks, energy consumption and area coverage are two well-known optimization problems. An efficient and restricted... | Find, read and cite all the research you need on ResearchGate FIS-RGSO: Dynamic Fuzzy Inference System Based Reverse Glowworm Swarm Optimization of energy and coverage in green mobile wireless sensor networks Computer Communications 163(10):12-34 DOI: 10.1016/j.comcom.2020.09.002 Abstract In mobile wireless sensor networks, energy consumption and area coverage are two well-known optimization problems. An efficient and restricted sensor movement is essential so that redundant area coverage, as well as consumed energy, can be reduced to mitigate these two issues in mobile wireless sensor networks. To make equilibrium between energy consumption and the total area coverage by the sensor nodes is a difficult task. In this context, optimized path planning for sensor movement is crucial to reach the target. The article presents a Dynamic Fuzzy Inference System Based Reverse Glowworm Swarm Optimization (FIS-RGSO) of energy and coverage in smart green mobile wireless sensor networks. The objective of this article is to achieve minimum energy consumption by the sensors through their optimum movements so that sensors can cover maximum area and increase their lifetime. The proposed approach improves the sustainability and performance of green sensor networks in terms of a lifetime and energy-efficiency by implementing restricted and organized sensor movements based on the decision taken by the Fuzzy Inference System, which leads to minimum energy consumption and less distance traversing. The simulation results reveal that our proposed model reduces the consumed energy in a range of 5%–45% as compared with the existing method in reverse glowworm swarm optimization (RGSO) algorithm. The total distance covered by the sensors is also minimized by almost 7%–62% as compared with the existing one. The proposed method has experimented extensively and the result shows it performs better than the existing one in terms of the total number of live sensors that exist after execution. Therefore, the proposed methodology is realized as an energy-efficient model in wireless sensor networks that proliferate network lifetime. ... In 2020, Chowdhury and De 26 had developed a new model called "dynamic fuzzy inference system based reverse glowworm swarm optimization (FIS-RGSO)" in smart green Mobile Wireless sensor Networks (MWSNs) by considering the coverage and energy constraints. The major aim of this developed model was to attain minimal energy consumption through the sensors based on the optimal movement of sensors to maximize the lifetime and area of networks. ... ... The sensing area of the sensors is greatly utilized. In FIS-RGSO, 26 the lifetime of the sensor depends on the energy consumed while the sensor moves when an obstacle is sensed. FLC-based FODPSO 27 is highly reliable and accurate in its performance. ... ... In I-AREOR, 25 sensor movements are minimized, and thus, overlapping of sensors is avoided. In FIS-RGSO, 26 the progress in the three-dimensional workspace is not discussed. FLC-based FODPSO 27 requires additional Wind Energy Conversion Systems (WECS) systems to adjust the duty cycle of the power converter and maximize the energy of the system. ... A novel hybrid meta‐heuristic concept for green communication in IoT networks: An intelligent clustering model Article Full-text available Apr 2022 INT J COMMUN SYST Md Mobin Akhtar Danish Ahamad Alameen Abdalrahman Ahmad Saleh Shatat Nowadays, there is an emerging need for applications based on the Internet of Things (IoT). The sensor nodes present in the IoT network produce data constantly, which directly influences the durability of the network. Therefore, two major challenges while designing IoT systems are network lifetime and energy consumption. Although the ability of IoT applications is huge, there are several limitations such as energy optimization, heterogeneity of devices storage, load balancing, privacy, and security that have to be addressed. These constraints have to be optimized for improving the efficiency of the networks. Hence, the main intention of this paper is to develop the intelligent‐based cluster head selection model for accomplishing green communication in IoT. The two famous algorithms like spotted hyena optimization (SHO) and sun flower optimization (SFO) are integrated to form sun flower‐spotted hyena optimization (SF‐SHO) by utilizing the hybrid meta‐heuristic concept for the optimal cluster head selection. The most significant parameters in IoT networks like delay, distance, energy, temperature, and load are considered for deriving a multi‐objective function to offer optimal clustering. The cluster head of the model is optimally tuned based on the hybrid SF‐SHO, to solve the multi‐objective problem, thus showing the enhanced green communication performance. The proposed model is analyzed and evaluated over different approaches in terms of energy‐specific factors, and the attained results confirm the efficiency of the developed method. ... e typical representative of this strategy is the Dynamic Virtual Force-Based Algorithm (VFE) proposed by Luo and Cai for data aggregation, which can adapt to different scene changes [4,5]. e energy-saving self-deployment scheme proposed by Han et al. utilizes the attractive force generated by the centroid of the local Voronoi polygon of the sensor and the repulsive force often used in the selfdeployment scheme using the potential field [6, 7] . ese networks using virtual power ideas have significant improvements in latency and packet loss due to dynamic changes in sensor or node locations. ... ... Deterministic methods include both conventional methods and planning methods. is type of approach uses statically deployed sensors to achieve full coverage. is method can also improve the sensing efficiency of coverage with a smaller number of sensors [7] . However, the deterministic strategy of WSN placement (peer-to-peer) can be used for small-scale deployments [10]. ... ... Besides, the deployment method only focuses on the coverage performance of the event and does not consider the connectivity of the network. Ghowdhury and De proposed an energy-efficient self-deployment scheme that takes advantage of the attractiveness of the centroid of the sensor's local VORONOI polygon and the repulsive force often used in self-deployment scenarios using the potential field [7] . In contrast to existing self-deployment solutions, we also provide the design and implementation of a simulator for analyzing the performance of the proposed method. ... Event-Sensitive Network: A Construction Algorithm of Agricultural Sensor Network Driven by Environmental Change Jan 2021 MATH PROBL ENG Shipu Xu Yong Liu Wenwen Hu Chang Liu In a wireless sensor network, the sensor nodes transmit the acquired information to the server through the data transmission link. On the serverside, the data are processed, fused, and expressed to serve the user. Sensor deployment is a key factor related to the stability and security of wireless networks. This article uses environmental changes to drive related technologies to deploy wireless sensors. In this article, environmental change-driven means that through certain deployment cost model assumptions and problem descriptions, network deployment is artificially divided into two stages: initial deployment and redeployment. In the deployment phase, by referring to the idea of virtual force, a new sensor deployment algorithm is proposed in the redeployment phase, which can well solve the stability- and security-related issues encountered in agricultural wireless sensor networks. In this algorithm, the moving distance of the mobile receiver and the average coverage of the network are calculated based on the virtual force, the direction, and the number of adjacent clusters. Finally, the algorithm model was simulated in MATLAB, and the feasibility of the algorithm was verified by analyzing the event coverage and the moving distance of nodes. The final simulation results show that the algorithm proposed in this paper can achieve better performance than existing algorithms in terms of average coverage and moving distance. ... The algorithm is energy efficient and outperforms the existing evolutionary methods like improving particle swarm optimization (IPSO) includes a quicker convergence. "Reverse glowworm swarm optimization" (Chowdhury and De 2020) proposes green sensor network to improve the performance and energy efficiency. Fuzzy inference system is utilized to reduce the energy consumption and distance traversing. ... ICACECS 2022 Book Proceedings LNNS Volume 612 22-03-2023 Brahmananda Reddy Annapu Reddy Srujan kotagiri Raju This book includes original, peer-reviewed research articles from International Conference on Advances in Computer Engineering and Communication Systems (ICACECS 2022), held in VNR Vignana Jyoythi Institute of Engineering and Technology (VNR VJIET), Hyderabad, Telangana, India, during August 11–12, 2022. The book focuses on “Smart Innovations in Mezzanine Technologies, Data Analytics, Networks and Communication Systems” enlargements and reviews on the advanced topics in artificial intelligence, machine learning, data mining and big data computing, knowledge engineering, semantic Web, cloud computing, Internet of Things, cybersecurity, communication systems, and distributed computing and smart systems. ... The algorithm's efficacy was evaluated in a real-world irrigated agriculture scenario. Chowdhury et al. [17] came up with FIS-RGSO, a reverse firefly swarm optimization-based dynamic fuzzy inference system. Fuzzy inference system decision-making enables restricted and structured sensor movement, which increases the network's sustainability, and in regard to lifetime and uniformity, the effects are excellent. ... VKECE-3D: Energy-Efficient Coverage Enhancement in Three-Dimensional Heterogeneous Wireless Sensor Networks Based on 3D-Voronoi and K-Means Algorithm Article Full-text available Jan 2023 SENSORS-BASEL Pingzhang Gou Baoyong Guo Miao Guo Shun Mao During these years, the 3D node coverage of heterogeneous wireless sensor networks that are closer to the actual application environment has become a strong focus of research. However, the direct application of traditional two-dimensional planar coverage methods to three-dimensional space suffers from high application complexity, a low coverage rate, and a short life cycle. Most methods ignore the network life cycle when considering coverage. The network coverage and life cycle determine the quality of service (QoS) in heterogeneous wireless sensor networks. Thus, energy-efficient coverage enhancement is a significantly pivotal and challenging task. To solve the above task, an energy-efficient coverage enhancement method, VKECE-3D, based on 3D-Voronoi partitioning and the K-means algorithm is proposed. The quantity of active nodes is kept to a minimum while guaranteeing coverage. Firstly, based on node deployment at random, the nodes are deployed twice using a highly destructive polynomial mutation strategy to improve the uniformity of the nodes. Secondly, the optimal perceptual radius is calculated using the K-means algorithm and 3D-Voronoi partitioning to enhance the network coverage quality. Finally, a multi-hop communication and polling working mechanism are proposed to lower the nodes’ energy consumption and lengthen the network’s lifetime. Its simulation findings demonstrate that compared to other energy-efficient coverage enhancement solutions, VKECE-3D improves network coverage and greatly lengthens the network’s lifetime. ... "Fuzzy Inference System-based Reverse Glowworm Swarm Optimization (FIS-RGSO)" [35] is a suggested method for reducing WSN energy usage by identifying the most efficient path to the destination. FIS-sensors RGSOs are designed to move as efficiently as possible to use the least energy potential while also extending their lifespan. ... Erudite Fish Swarm Optimization Based Routing Protocol to Maximize Wireless Sensor Network Lifetime Article Jun 2022 A. Balasubramanian P. Ponmuthuramalingam ... Deepa et al. [10] proposed to use levy flight to enhance WOA for guaranteeing the network coverage. Other intelligent optimization algorithms, including the bee algorithm [11,12], the weed algorithm [13], the wolf pack algorithm [14], the glowworm swarm optimization [15, 16] , the social spider optimization (SSO) algorithm [17], the multi-objective immune co-evolutionary algorithm (MOICEA) [18], the simulated annealing (SA) [19], the ant colony optimization (ACO) [20], ... Coverage Optimization of Wireless Sensor Networks Using Combinations of PSO and Chaos Optimization Article Full-text available Mar 2022 Qiang Zhao Changwei Li Dong Zhu Chunli Xie The coverage rate is the most crucial index in wireless sensor networks (WSNs) design; it involves making the sensors with a reasonable distribution, which closely relates to the quality of service (QoS) and survival period of the entire network. This article proposes to use particle swarm optimization (PSO) and chaos optimization in conjunction for the coverage optimization. All sensor locations are encoded together as a particle position. PSO was used first to make sensors move close to their optimal positions; furthermore, a variable domain chaos optimization algorithm (VDCOA) was employed to reach a higher coverage rate, along with improved evenness and average moving distance. Six versions of VDCOA, taking circle, logistic, Gaussian, Chebyshev, sinusoidal and cubic maps, respectively, were investigated. The simulation experiment tested three cases: square, rectangular and circular regions using nine algorithms: six versions of PSO plus VDCOA, PSO and other two PSO variants. All six versions showed better performance than PSO and CPSO, with coverage all exceeding 90% for the first two cases. Moreover, one version, PSO plus circle map (PSO-Circle), increased the coverage rate by 3.17%, 2.41% and 12.94% compared with PSO in three cases, respectively, and outperformed the other eight algorithms. ... The solution involves the partial use of heuristic initialization, the new fitness function, the modified virtual force algorithm, the inclusion of a uniform deceleration to the estimation of inertia weight and the addition of the impact of the subpopulation' head individuals. The study in [69] proposed a Dynamic Reverse Glowworm Swarm Optimization (FIS-RGSO) based Dynamic Fuzzy Inference Method of energy and coverage in smart green mobile WSNs with the goal of achieving minimal energy utilization by the nodes through their optimal motions so that nodes can cover greater area and increase their lifespan. The proposed solution boosts the lifespan and energy-efficiency, and the performance of green WSN is enhanced by taking better and coordinated node movements based on the Fuzzy Inference method, resulting in minimum power consumption and less distance traversal. ... Coverage, Deployment and Localization Challenges in Wireless Sensor Networks Based on Artificial Intelligence Techniques: A Review Article Full-text available Jan 2022 Walid Osamy Ahmed M. Khedr Ahmed Salim Ahmed Elsawy The growing importance and widespread adoption of Wireless Sensor Network (WSN) technologies have helped the enhancement of smart environments in various fields such as manufacturing, smart city, transport, health and the Internet of Things, by providing pervasive real-time applications. In this paper, we analyze the existing research trends of Coverage, Deployment and Localization challenges in WSN concerning Artificial Intelligence (AI) methods for WSN enhancement. We present a comprehensive discussion on the recent studies that utilized various AI methods to meet specific objectives of WSN, from 2010 to 2021. This would guide the reader towards an understanding of up-to-date applications of AI methods with respect to different WSN challenges. Then, we provide a general evaluation and comparison of different AI methods used in WSNs, which will be a guide for for research community in identifying the most adapted methods and the benefits of using various AI methods for solving the Coverage, Deployment and Localization challenges related to WSNs. Finally, we conclude the paper by stating the open research issues and new directions for future research. ... The authors of [36] propose a new optimization algorithm, able to manage nodes mobility with the main aim of reducing the total energy consumption, while maintaining the optimal coverage of the considered area. Their idea is based both on Fuzzy Logic (a Fuzzy Inference System governs sensor movements) and Swarm Intelligence and it is able to achieve the minimum energy consumption while optimizing sensors movements, in order to cover the maximum achievable area. ... Advanced Resources Reservation in Mobile Cellular Networks: Static vs. Dynamic Approaches under Vehicular Mobility Model Article Full-text available Sep 2021 Peppino Fazio Mauro Tropea Many studies in literature have shown that the bandwidth of an ongoing flow can dynamically change during multimedia sessions and an efficient bandwidth allocation scheme must be employed. This paper focuses its attention on the management of predictive services in Wireless Infrastructure Dynamic Networks. In particular, two classes of service are considered: NSIS-Mobility Independent Predictive and NSIS-Mobility Dependent Predictive, where NSIS is the Next Steps in Signaling protocol, employed for resources reservation in Integrated Services architectures. A general prediction technique is proposed, based both on the analysis of time spent into a cell by mobile nodes and on the probabilities of hand-in and hand-out events of mobile nodes from wireless cells. User mobility needs to be firstly analyzed and a novel realistic mobility model has been considered, differently from some existing works in which synthetic mobility is generated. The analysis of user mobility is mandatory when the reduction of passive resource reservations for NSIS-MIP users is desired, with a good enhancement in system utilization. Moreover, predictive reservation and admission control schemes have been integrated. The performance of the 2D wireless system is evaluated in terms of average system utilization, system outage probability, number of admitted flows and reservation prediction errors. We provided to carry out an extensive simulation campaign, in order to assess the goodness of the proposed idea: we verified that good results (in terms of perceived utility, bandwidth and admitted flows) can be obtained, outperforming also some existing works. DEEC-Based Meta-heuristic Unequal Clustering Scheme for Energy Sustenance of Heterogeneous Nodes in WSN Chapter Mar 2023 Swapna M P G. Satyavathy Wireless sensor network (WSN) is becoming denser and more heterogeneous each and every day, with the overwhelming impact of technologies like IoT. Managing the energy and maintaining the lifetime longevity of the heterogeneous WSN is a challenging task. Unequal clustering is one of the imperative solutions for maintaining energy efficiently, ideal for minimizing hotspot problem in WSN. Heterogeneity of nodes in WSN needs apposite attention to avoid energy depletion of low energy nodes. This paper proposes the novel algorithm, clustering of heterogeneous nodes with bat algorithm (CHNBA) that integrates the uniform energy dissemination protocol, distributed energy efficiency clustering (DEEC) with unequal clustering. The location of cluster head (CH) is optimized using the bio-inspired improved bat algorithm. DEEC has high ability to assure heterogeneity performance and clustering stability, while optimized unequal clustering ensures energy efficiency resulting in prolonged network lifetime. The effectiveness of the algorithm was experimented using MATLAB simulations. The results proved that the protocol, CHNBA, is effective for the energy sustenance of a network. It outperforms the existing clustering protocols in energy efficiency, network lifetime, throughput, packet delivery ratio and stability.KeywordsHeterogeneous WSNUnequal clusteringCompetition radiusResidual energyCluster headStability RGSO-UAV: Reverse Glowworm Swarm Optimization inspired UAV path-planning in a 3D dynamic environment Article Dec 2022 AD HOC NETW Aparajita Chowdhury Debashis De Three-dimensional path planning for UAVs is a very complex, NP-hard optimization problem. It is an effort to resolve the best feasible trajectory between the source and the destination while prohibiting collision in a dynamic environment. Many researchers have proposed different deterministic and non-deterministic solutions to the path-planning problem. However, it is still open to new promising methods to acquire better quality solutions with minimum time complexity. This article presents a novel methodology inspired by the Reverse Glowworm Swarm Optimization (RGSO) algorithm to resolve this problem for the UAV without colliding with any dynamic and static obstructions appearing in its path. A tuned path is generated after the initial one to optimize further and smoothen the trajectory. The proposed method has been extensively experimented with, and the outcomes show it outperforms the other algorithm in a three-dimensional dynamic environment in a path-planning strategy. The result shows that our proposed scheme reduces the value of the cost function by approximately 49% - 107% less than other existing approaches, and the execution time of this mechanism reduces by 2% - 61% compared with other existing methods. Thus, the proposed technique RGSO-UAV is an optimal and energy-efficient path-planning model in flying ad-hoc networks that enhance UAV's lifetime. Special Issue on Smart Green Computing for Wireless Sensor Networks Article May 2022 COMPUT COMMUN Chetna Singhal Deepak Kumar Jain Alberto Tarable Anand Nayyar
https://www.researchgate.net/publication/346783812_FIS-RGSO_Dynamic_Fuzzy_Inference_System_Based_Reverse_Glowworm_Swarm_Optimization_of_energy_and_coverage_in_green_mobile_wireless_sensor_networks
Water | Free Full-Text | An Overview of Hybrid Water Supply Systems in the Context of Urban Water Management: Challenges and Opportunities This paper presents a critical review of the physical impacts of decentralized water supply systems on existing centralized water infrastructures. This paper highlights the combination of centralized and decentralized systems, which is referred to as hybrid water supply systems. The system is hypothesized to generate more sustainable and resilient urban water systems. The basic concept is to use decentralized water supply options such as rainwater tanks, storm water harvesting and localized wastewater treatment and reuse in combination with centralized systems. Currently the impact of hybrid water supply technologies on the operational performance of the downstream infrastructure and existing treatment processes is yet to be known. The paper identifies a number of significant research gaps related to interactions between centralized and decentralized urban water services. It indicates that an improved understanding of the interaction between these systems is expected to provide a better integration of hybrid systems by improved sewerage and drainage design, as well as facilitate operation and maintenance planning. The paper also highlights the need for a framework to better understand the interaction between different components of hybrid water supply systems. An Overview of Hybrid Water Supply Systems in the Context of Urban Water Management: Challenges and Opportunities by Mukta Sapkota 1,* , Meenakshi Arora 1,† , Hector Malano 1,† , Magnus Moglia 2,† , Ashok Sharma 3,† , Biju George 4,† and Francis Pamminger 5,† 1 Department of Infrastructure Engineering, Melbourne School of Engineering, University of Melbourne, VIC 3010, Australia 2 Commonwealth Scientific and Industrial Research Organization (CSIRO) Land and Water, Highett, VIC 3190, Australia 3 Institute of Sustainability and Innovation, Victoria University, Melbourne, VIC 3030, Australia 4 International Centre for Agricultural Research in the Dry Areas, P.O. Box 2416, Cairo, Egypt 5 Yarra Valley Water, Mitcham, VIC 3132, Australia Author to whom correspondence should be addressed. Water 2015 , 7 (1), 153-174; https://doi.org/10.3390/w7010153 Received: 12 November 2014 / Accepted: 23 December 2014 / Published: 29 December 2014 Versions Notes Abstract : Keywords: hybrid water supply systems wastewater stormwater water infrastructures Graphical Abstract 1. Introduction Provision of centralized water, wastewater and stormwater services for urban areas has been common practice for over 100 years [ 1 , 2 ]. While such facilities have been in use since the mid-1800s for water and waste water services, it has become increasingly clear in recent years that alternative technical solutions can improve the efficiency and infrastructure functions in urban water management, especially in water scarce areas [ 3 , 4 ]. In the context of changing societal expectations, urban water managers are confronted with increasingly complex and multi-faceted challenges, in particular when the existing and available resources reach the limits of sustainable exploitation [ 5 ]. Furthermore, the urban water sector is required to meet increasing demand from growing populations, changing climate, resource availability and at time, some level of community desire for protecting and improving stressed ecosystems [ 6 , 7 , 8 ]. Infrastructure investment and replacement is a gradual process and changing the whole infrastructure is neither economically nor environmentally sustainable [ 9 ]. With a legacy of centralized infrastructure solutions in combination with growing investment in decentralized infrastructure solutions, the result is a hybridization process where mix of centralized and decentralized systems co-exists. However, there is limited practical or scholarly understanding of how to enable such transition of traditional urban water systems towards hybrid systems [ 10 ]. These technologies introduce interactions between the various components of the water cycle such as potable water, wastewater and stormwater [ 11 ]. This paper highlights the need for additional research to understand the impacts of hybrid water supply systems in water quality and quantity, in particular, the interaction of these systems with the local environment at a strategic level. Though hybrid technologies may offer benefits in terms of accommodating growing water needs and thus decreasing peak demand from centralized water supply system [ 4 , 12 ], they may have implications on the operational performance of the downstream infrastructure and existing treatment processes. Therefore, combinations of water supply systems should not be decided upon only on the basis of the availability and demand for water [ 4 ]. Hence, this review paper discusses the gaps in understanding of the likely impacts of each of these decentralized technologies on wastewater and stormwater quantity and quality when combined with existing centralized systems. At the beginning, this paper provides challenges of existing centralized and decentralized water supply systems. Then, the paper illustrates the potential impacts of decentralized water supply systems on centralized systems. Later, it introduces hybrid systems as a solution to present water supply problems along with opportunities and challenges of such systems. Finally, it highlights the need of a methodology to assess hybrid systems. 2. Present Water Supply Systems Challenges 2.1. Centralized Water Supply Systems In general, centralized water services have ensured adequate water supply, sanitation and drainage services to its inhabitants in cities [ 13 , 14 ]. However, demographic changes including the ageing population, socio-economic factors, climate change, biodiversity, energy use, water supply and consumption, as well as ageing water and wastewater infrastructures has put increasing pressure on these urban water systems [ 1 , 15 ]. Marlow et al. [ 16 ] has also raised similar concerns on centralized urban water systems, which are maladapted to these challenges. In addition, the typical centralized system can limit the potential to adapt water supply systems to local opportunities and needs [ 1 ]. As a result, in some circumstances these water infrastructures are considered to be unsuitable to address future challenges [ 17 , 18 , 19 ]. In the face of future uncertainties and threats, there is a need for water systems to provide ecologically sustainable services [ 20 ]. In many cases, the conventional approach to the water service provision does not comply with the more recent aspirations of ecologically sustainable development [ 21 ]. Decentralized water infrastructure is an alternative to the traditional centralized systems for implementing sustainable water infrastructure in urban setting [ 22 ]. Sharma et al . [ 23 ] has defined decentralized system as the system provided for water, wastewater and stormwater services at the property, cluster and development scale that utilizes alternative water resources, including rainwater, wastewater and stormwater, based on a ‘fit for purpose’ concept. Moreover, the combination of decentralized water supply systems with the centralized system can contribute to the provision of sustainable water supply [ 22 ]. The following section provides a detail description of decentralized water system to better understand the scope of a combined water supply system and identify the research gaps in this area. 2.2. Decentralized Water Supply Systems 24 25 22 26 27 28 et al 29 reducing the cost of infrastructure for long distance transport and treatment of stormwater, potable water and sewage, along with unnecessary treatment to potable standards of water used for purposes other than drinking and bathing; more efficient use of resource; improving service security; reducing water systems’ failure risk; strengthening local economies; regenerating and protecting the natural environment; fortifying community well being. Decentralized systems also reduce reliance on traditional water sources and provide long-term ecological sustainability [ 29 , 30 ]. Although decentralized systems show significant promise, there are numerous unknowns and uncertainties that need to be addressed [ 31 ]. These systems are relatively new compared to centralized systems with limited understanding of ongoing management requirements and operation under dispersed accountabilities. The lack of knowledge around the long term performance of decentralized systems relate to issues such as long term reliability, operation and maintenance costs, interaction with centralized systems, appropriate costing, and adequate governance and guidelines [ 1 , 32 ]. These knowledge gaps impede mainstream acceptance of decentralized systems. Although these technologies are considered to offer benefits in terms of reducing overall potable water use and decreasing peak demand [ 33 , 34 ], they could have implications on the operational performance of the downstream infrastructures and treatment processes. For instance, as water saving through recycling is encouraged by adopting grey water reuse, dual piping systems and sewer mining, the volume of wastewater may decrease, but this could lead to an increasing in the concentration of key contaminants [ 24 ]. Increased concentration of contaminants in wastewater has been known to cause sewer problems, such as sewer blockage, odor and corrosion [ 35 ]. Therefore, whilst the investment in decentralized water system technologies can be warranted for developments in growth areas of cities, assessing the impacts of decentralized systems on the existing developments remains challenging due to the lack of understanding of the interaction between decentralized and centralized systems [ 35 , 36 ]. Further adoption of the decentralized systems has thus far been limited to demonstration projects [ 37 ]. Therefore the main objective of this paper is to examine the existing states of knowledge of these interactions and identifying the critical knowledge gaps. 2.3. Urban Water Cycle Figure 1 below shows the urban water cycle’s main components, pathways and alternative supply options in the urban water system. There are two main subsystems within the urban water cycle: the rainfall-stormwater discharge and supply-wastewater system. These two systems are inter-dependent, interacting to a varying degree depending on the location, season and utilization of wastewater and storm water as a supply source for water applications. There is interconnectedness among water supply, wastewater and storm water along with a broad range of non-conventional water supply technologies such as rainwater tanks, stormwater harvesting, and wastewater reuse within the system. Changes in one component of the water cycle can have impacts on the other components. Hence, addition of different alternative water service infrastructure can bring changes in the overall urban water system, which has been discussed in the following section. Figure 1. Urban water cycle’s main components, pathways and novel technologies (Green colored boxes indicate decentralized components of water cycle). Figure 1. Urban water cycle’s main components, pathways and novel technologies (Green colored boxes indicate decentralized components of water cycle). 3. Effects of Alternative Water-Service Infrastructure on Centralized Water System 12 38 39 However, such approaches are relatively new compared to traditional centralized approaches due to limited information available on their planning, design, implementation, reliability and robustness. Hence, to enable hybrid water supply systems as a viable option, it is necessary to understand their performance and impacts. In the next section, we provide a brief background of various alternative water service infrastructures that helps to better understand and analyze the effects of decentralized infrastructures on centralized water systems. 3.1. Water Reclamation and Reuse Reclaimed water can be defined as the treatment of wastewater for subsequent use as a water supply [ 7 ]. Common uses are both landscape and agricultural irrigation [ 40 , 41 ]. Other reuse options include industrial reuse such as cooling water, process water, and boiler feed water [ 42 ]. In some regions, reclaimed water is used for groundwater recharge to replenish depleted aquifers and to prevent salt water intrusion [ 7 ]. It can also be used for non-potable uses such as toilet flushing, air conditioning and fire flow [ 43 ]. Due to the difficulty of developing new freshwater resources, water reclamation and reuse are important additional water resources. This is a very reliable alternative water resources because of its supply reliability and lower pollution level of reclaimed water [ 44 ]. It can provide fit-for-purpose water supply under local control and avoid or delay construction of new large-scale water supply infrastructure. Additionally, it reduces the quantity of treated wastewater discharged to surface waters [ 45 ]. It is considered as one of the main options to remedy water shortage caused by increasing water demand, climate change and population growth [ 46 ]. Wastewater reuse can provide relatively constant supply because its source is the used potable water, which remains relatively constant throughout the year [ 47 ]. Moreover, recycled supply can significantly reduce the peak demand on potable water supply infrastructure [ 48 ]. Wastewater recycling may be beneficial if the solids are also removed and disposed via the solid waste system [ 49 ]. Solid deposition in sewer system had been known to have adverse effects on the hydraulic performance of the system and also on the environment [ 50 ]. It can alter the hydraulic radius of the pipe changing the self-cleansing velocity requirement for the pipe [ 51 ]. Hence, if only the water is intercepted and the residuals are discharged back to the sewerage networks, there will be a potential for frequent sewer blockage [ 35 ]. Further, if recycling of such water is for household non-potable use, then a potential drawback is the cost of establishing second system of household plumbing with safeguard against cross-connection [ 52 ]. 3.2. Grey Water Recycling and Reuse Greywater is defined as wastewater generated from all domestic sources except the toilet [ 53 , 54 ]. Almost 50%–80% household wastewater is greywater [ 55 ]. Grey water can have many uses depending upon the quality of greywater and treatment it has received. Two common uses for greywater are toilet flushing and lawn irrigation. Untreated greywater can be used for subsurface irrigation [ 56 ]. Grey water reuse can help to reduce reliance on traditional water sources that are under stress and it can also significantly reduce wastewater discharge [ 57 , 58 ]. Because the amount of greywater produced in a household and the amount of water used for toilet flushing in a household are nearly the same, grey water systems have the potential of more or less replacing the household water demand for toilet flushing thus potentially reducing potable water usage by up to 30% [ 59 , 60 , 61 ]. Water recycling can help achieve control of sewer flooding. It reduces the quantity of wastewater that is produced, and thus the capacity of the sewer network to cope with heavy rainfall events will be increased in case of combined sewers [ 62 ]. Bertrand et al. [ 63 ] mentioned that greywater recycling has the capacity to significantly reduce sewer flooding for storm events of up to five years return period. Also, it is less vulnerable to climate variations compared to the traditional sources of water [ 64 , 65 ]. Radcliffe [ 66 ] states that it may reduce the environmental impacts of treated sewage that would be otherwise discharged to the environment. Moreover, this local water recycling reduces the need for further expansion of the main water infrastructure as the population density increases [ 67 ]. However, the implementation of greywater recycling involves a reduction in the volume of wastewater discharged and an increase in concentration of pollutants [ 53 , 68 ]. This reduction in wastewater volume increases the potential for septicity, odors, contaminant impacts and corrosion in the assets [ 24 ]. Similarly, greywater irrigation (domestic garden irrigation with household wastewater) can cause dry weather pollution (drainage effluent from greywater irrigation) of receiving waters [ 49 ]. In such situations, water reuse can aggravate the environmental problems. 3.3. Rainwater Harvesting Rainwater harvesting is the collection and use of rainwater for domestic purposes. This supplements municipal drinking water supply and is believed to minimize stress on stormwater infrastructure [ 7 , 69 , 70 , 71 , 72 ]. It can potentially save a significant amount of domestic water demand [ 60 , 73 , 74 ]. An Australian study showed a savings of 12.3% to 25.1% in potable water use when harvested rainwater was used for toilet flushing and garden irrigation [ 56 ]. Moreover, this rainwater is a relatively high quality water source that can be directly used for non-potable uses, or with filtration and disinfection for potable uses [ 75 , 76 ]. The use of tanks to harvest and store rainwater also has the potential to restore some aspects of pre-development flow regimes in receiving water [ 77 ]. The use of rainwater harvesting is also beneficial to sewers and improves wastewater treatment in the case of combined sewer networks [ 35 , 63 , 70 ]. An additional benefit of the use of rainwater tanks to supplement the existing water supply is to reduce localized urban flooding, improve stormwater quality (as these pollutants will remain in the tank) and minimize influx of stormwater into the sewer system [ 78 , 79 ]. Study from Zhang et al . [ 56 ] shows residential use of rainwater can decrease the stormwater runoff by 23.4% to 48.1%. According to Gardels et al . [ 80 ] rainwater runoff contains a nutrient such as nitrogen, so capturing rainwater reduces nitrogen loadings in receiving water bodies. Further, this nitrogen loading in the rainwater, if used for landscape irrigation, can also reduce the amount of fertilizer needed for the landscape [ 80 ]. But, wastewater from rainwater harvesting has higher level of metal content (lead and iron) [ 81 ], which may react with dissolved sulfide to form metal sulfide precipitates and can cause corrosion in the pipes [ 35 ]. Also, there is difficulty in managing rainwater tanks as currently there is no mechanism in place to make sure that the household rainwater collection systems are maintained and in a good condition [ 82 ]. 3.4. Stormwater Harvesting Stormwater is the runoff from pervious and impervious areas collected via the drainage system [ 83 ]. Stormwater is considered fit to cater for non-potable water demands and is emerging as a viable option to augment increasingly stressed urban water supply systems [ 84 , 85 ]. The other merit is that it slows stormwater flow, thereby reducing peak flows in waterways [ 86 ]. Hence, they have the dual purpose to provide water supply as well as reduce urban flooding [ 87 ]. However, excessive harvesting of urban stormwater runoff could be detrimental to stream health if critical aspects of the flow regime were changed away from, rather than toward, their pre-urban condition [ 88 ] and most of the environmental flow problems arise from this practice [ 89 ]. Hering et al. [ 90 ] also urges that more research is needed in stormwater harvesting mainly to assess the water quality implications of this practice. Having discussed various decentralized water supply systems, it has been identified that combining such systems with centralized system may potentially resolve many existing challenges in the urban water system such as meeting rising needs of water and offering a wide range of flexibility in implementation. 4. Hybrid Water Supply Systems Following the literature review, the definition of hybrid systems provided by Daigger and Crawford [ 12 ] has been adapted to develop a generalized definition of hybrid water supply systems. Hybrid water supply systems can be defined as systems provided for water services through a centralized water supply system in combination with decentralized water supply options such as rainwater tanks, storm water harvesting, and water reuse. Internationally, hybrid water systems have been referred in different ways such as semi-centralized supply and treatment [ 38 , 39 , 91 , 92 ], distributed water supply system [ 29 , 81 , 93 , 94 ], semi-decentralized systems [ 95 ] and hybrid system [ 12 , 96 ]. These systems can be considered as part of a sustainable urban water management strategy whereby there is adoption of alternative water supply and wastewater management approaches while the predominant model of service remaining the centralized water supply system [ 5 , 16 ]. These types of hybrid water supply systems can be also compared with “The Soft Path of Water” [ 97 ] approach, which not only uses centralized infrastructure but also takes advantages of the potential for decentralized facilities to meet the water related needs. These innovations in water management help to reduce the volume of water imported to cities, and decrease the volumes of wastewater and storm water discharged into the environment [ 78 ]. On the other hand, such transition of traditional urban water system to hybrid water supply systems have significant effects on central networks [ 13 ], particularly the sewage network and storm water drains. The use of decentralized water supply options changes both the wastewater and stormwater flow regimes and contaminants’ composition [ 36 , 93 , 98 ]. Thus it can be argued that while these hybrid water supply systems seem to be promising, there are some inherent challenges such as public acceptance, particularly for new technologies and unfamiliar practices (e.g., greywater recycling), unknown impacts, understanding the interaction between centralized and decentralized services and diverse infrastructure management. The following sections shed light on inertia in water infrastructure, and various prospects and challenges of hybrid water supply systems. 4.1. Inertia in Water Infrastructure and Hybrid Water Supply Systems As shown in Figure 2 , there are two contrasting approaches to urban water management, a conventional paradigm based on traditional centralized approaches (common in practice); and an emerging paradigm around decentralized infrastructures [ 99 ]. Currently, there is a debate between fully centralized or decentralized approach to urban water service provision. The traditional, centralized water servicing system provides clean drinking water, sanitation and protection from urban flooding [ 100 ]. These systems are cost effective and reliable [ 5 , 100 ]. In contrast, decentralized system is based on principle of ecological sustainability and can manage water cycle by protecting the natural environment. There are diverse supply sources in decentralized system, which makes the system more flexible. Hybrid water systems combine the merits of both the centralized and decentralized systems. Furthermore, achieving a paradigm shift in water management may be a hard task due to the inertia that accompanies existing technological regimes [ 101 ]. Sunk investments and well-established socio-technical regime creates the path dependencies that favor the prevalence of the existing centralized model [ 102 ]. In addition to this, there are other factors such as institutional barriers, public health issues, peak demand (for example fire fighting demand) and supply safety that impedes the adoption of decentralized system. Other impediments to decentralized water system can be found in various literature sources [ 102 , 103 , 104 , 105 ]. Hybrid Systems can provide a balance between them and act as a transition towards more sustainable urban water systems. Figure 2. Inertia in water infrastructure system. Figure 2. Inertia in water infrastructure system. 4.2. Advantages of Hybrid Water Supply Systems Hybrid water supply systems are innovative approaches to respond to water scarcity caused by population growth and uncertainties in climate change. They can enhance the water security through local source diversification [ 16 ]. Such diversification of water sources using alternative local water sources reduces the amount of water abstracted from waterways, groundwater or dams and hence improves water security [ 20 , 106 ]. They can build adaptive capacity by increasing the diversity and flexibility of water supply systems [ 29 ]. According to Weber et al . [ 39 ], planning and construction time of such systems is shorter compared to centralized system. At the same time, they are more flexible as it is easier to adapt the design to local conditions. Similarly, in a case study carried out in Qingdao, China [ 38 ], it is shown that the integrated semi-centralized approach offers flexible solutions to cope with the new demands wherever certain thresholds of population density are exceeded. These are not only effective in the cities like Qingdao where population growth is high but also would be in cities of East Germany where population is shrinking [ 107 ]. Research shows that these types of systems have lower entry costs and are more flexible to adapt to demographic changes [ 108 ]. In this context, semi-centralized supply and treatment systems can open a wide scope of possibilities in resource management, especially by reducing fresh water demand of new urban areas. Further, it can reduce social, economic and environmental vulnerability to climate change by creating distributed water systems through infrastructure design choices at a range of scales from household to regional level. This ensures greater flexibility. In addition, the, planning and operation of decentralized systems being of a smaller scale, entail a lower level of implementation and operational risks [ 38 ]. Additionally, water infrastructure systems consisting of semi-centralized systems would be more resilient because a failure in these systems would only affect a small part of the urban area [ 107 ]. In addition to this, there are large savings potential in daily potable water demands through intra-urban water reuse [ 92 ]. Similarly, integrated systems can achieve energy reductions by onsite treatment of different wastewater flows as such treatment of sewage sludge and waste can reduce the greenhouse gas (GHG) emissions such as those arising from the sanitary landfills [ 38 ]. At the same time, sludge and waste fractions can be utilized for energy production and nutrient recovery [ 109 ]. Daigger and Crawford [ 12 ] and Daigger [ 7 ] have also demonstrated the capability of hybrid water systems to reduce potable water use and energy consumption and increase the potential for nutrient recovery on large urban areas. Hybrid systems can also help defer augmentation of existing infrastructure. For example, traditional water and wastewater pipe network design is driven to a large extent by the need to cater for peak demands. Mitigation of these peaks can be achieved through the use of decentralized solutions [ 34 , 48 , 110 , 111 , 112 ]. For example, Willis et al. , shows a huge reduction on diurnal peak of potable water demand with the use of recycled water supply for irrigation and toilet uses [ 48 ]. Speers and Mitchell [ 113 ] have also demonstrated that mitigation of these peaks can produce substantial cost reductions. Distributed used-water reclamation and reuse systems offer significant advantages including being close both to the source of wastewater generation and to potential water reuse [ 26 ]. This approach not only reduces the size of the non-potable water-distribution system but also reduces the required size of the used water conveyance system downstream of the diversion point, which can allow significant savings in the system in terms of cost and energy [ 96 ]. Biggs et al . [ 29 ] also illustrated the similar benefits from hybrid water systems using cases from Australia, Europe and the United States. The study assesses these cases based on their ability to reduce costs and resource uses improve service security and protect natural environment. 97 95 111 114 4.3. Challenges of Hybrid Water Supply Systems Despite having promising prospects, it can’t be ignored the fact that hybrid water supply systems are not free of challenges. Among these challenges, are extensive collection and distribution systems required for used-water reclamation and reuse particularly in the case of centralized, non-potable systems that need separate distribution for potable and non-potable water? The need for dual water-distribution systems presents a significant cost barrier, especially in existing urban areas, as well as a substantial increase in energy to convey both water supplies [ 96 ]. Furthermore, as a water source, the treatment of wastewater involves energy use that may be greater than surface water [ 115 ]. Further, there are challenges related to retrofitting, which is associated with limited land and high cost [ 114 ]. Another challenge in transforming the model of service provision from centralized to hybrid water supply systems is the investment cycles for infrastructure. This often occurs over timescales that are too short (e.g., five years) for decentralized water supply options while central infrastructure has a life span of decades [ 116 ]. In addition, significant gaps remain in terms of quantifying the benefits of recycled water scheme and thus it makes difficult to set the price of such water [ 117 ]. The implementation of decentralized water systems, particularly for non-potable use could increase the complexity of urban water systems, with water collection, storage and distribution occurring over multiple scales (household, neighborhood and city scales) [ 55 ]. The extensive implementation of hybrid water systems could increase self-similarity in urban systems, adding replication of functions in water circulation to the replication of form seen in a dendritic structure of sewerage and drainage networks [ 118 ]. Such water collection and circulation at multiple scales could lead to greater complexity and new patterns of order emerging out of the critical state of water infrastructure. 119 120 Cook et al . [ 81 ] demonstrate the impact of source management practices (SMPs) on the quality and load of wastewater. Marleni et al . [ 35 ] argue the need of further research to assess the potential impact that might arise from the implementation of alternative water sources such as grey water recycling, rainwater harvesting and wastewater recycling on sewage infrastructures. It is not yet clear whether these types of systems will affect water quality either adversely or favorably [ 121 ]. This echoes the finding from the analysis by Moglia [ 122 ] that shows the risks of decentralized water systems are yet to be understood. Makropoulos and Butler [ 93 ] have identified some of the main research needs in the area of hybrid water supply systems, especially in relation to the effects of the changing quantity and quality of wastewater and storm water on the existing infrastructure and the interactions between distributed water, energy and waste infrastructures. Speers and Mitchell [ 113 ] have also recognized that urban water systems are very complex and inter-related. Furthermore, they mention that changes to any part of system can have both downstream and upstream impacts that affect costs, performance, and future opportunities. The use of hybrid systems increases the complexity in our urban water system by adding more challenges. There will be differing water qualities and changing end use patterns and greater complexity, all resulting in new and increased risk to manage [ 123 ]. This leads to dynamic changes across multiple temporal and spatial scales that are often not intuitive even to experts [ 16 ]. Management of such complex system may need a high degree of monitoring with real time direct feedback for operations and water quality purposes, as well as monitoring of assets including pipes and water treatment systems [ 123 ]. This kind of monitoring can be very costly. Moreover, public acceptance of such systems is challenging. There is a significant research gap in the knowledge base of social drivers specific to the acceptance of these systems and the factors contributing to its widespread use [ 124 ]. Thus there is a large knowledge gap on operational performance, cost and energy usage of hybrid water supply system. For instance, there is a wide divergence in informed opinion on the levels of energy consumption for rainwater tanks and use of their water in household situations. Also, the level of externalities involved in wastewater discharge to aquatic ecosystems is often difficult to value, particularly for nitrogen discharge, and information is required to develop valid evaluation criteria. 4.4. The Need for Framework for Assessment of Hybrid Water Supply Systems After discussing the advantages and disadvantages of hybrid water systems, this leads to the question “can a mixture of decentralized and centralized system combine the advantage of both systems?” To answer this question, we need a robust methodology to assess the performance of hybrid systems. Traditionally, integrated assessment studies have presented an either/or approach, assessing one technology against another for a number of alternative systems and exclude options for partial contributions from multiple alternatives [ 99 ]. For example, Cook et al . [ 81 ] analyzed seven alternatives and Abrishamchi et al . [ 125 ] analyzed eight systems; but these methodologies exclude options of combined system and their benefits. Further, none of these methodologies evaluates the impacts of hybrid systems in terms of interaction between centralized and decentralized infrastructures. Also, though some of the frameworks evaluate the environmental impacts of hybrid systems [ 30 ], but do not evaluate the impacts from the implementation of hybrid systems on the quantity and quality of wastewater and stormwater in the existing centralized systems. Hence there is a need of comprehensive methodology for assessing the full range of technological alternatives available. The closest to a methodology for assessing the hybrid water system to date is presented in the paper by Sapkota et al . [ 4 ]. However this is a basic theoretical methodology that requires further empirical study to validate it. 5. Discussion This review highlights a range of decentralized water supply systems each with their specific advantages, issues and challenges. It also highlights that an adequate understanding of decentralized water supply systems and their interaction with central water infrastructures is necessary to bring significant environmental benefits and to enable deferring augmentation costs of large potable water supply, sewage and drainage systems. In areas with full use of existing centralized water supply system decentralized techniques such as rain water harvesting or recycled water supply can help to meet the additional water demand. The aim is to supply water services without changing the capacity of centralized system and subsequently reducing the cost of larger centralized water infrastructures. Thus, it is necessary to evaluate how the existing system integrates with alternative water supply options and what might happen over time. 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Subtotal or partial unilateral arytenoidectomy for treatment of arytenoid chondritis in five calves in: Journal of the American Veterinary Medical Association Volume 235 Issue 4 () Abstract Case Description—5 calves were evaluated for abnormal respiratory noise associated with variable degrees of respiratory distress. Clinical Findings—Tachypnea and inspiratory dyspnea were detected at initial evaluation in all calves. Endoscopic evaluation of the upper respiratory tract revealed enlarged and immobile arytenoids. Radiographic (n = 3) and computed tomographic (1) evaluation of the laryngeal area revealed images that were indicative of a large soft tissue mass at the level of the arytenoids obstructing the rima glottis. A presumptive diagnosis of arytenoid chondritis was made. Treatment and Outcome—A tracheostomy tube was placed in all calves. Medical treatment (with antimicrobials and anti-inflammatory drugs) was attempted in 4 calves after initial evaluation. Unilateral arytenoidectomy via a laryngotomy was performed under general anesthesia in all calves. Dysphagia and coughing were the most frequent postoperative complications. Three calves survived at least 6 months after the procedure. One calf died of a perforated abomasal ulcer 3 months after the surgery. Another calf died suddenly 1 month after the surgery of an undetermined cause. Clinical Relevance—Unilateral arytenoidectomy was a viable surgical treatment for arytenoid chondritis in calves. Further research in a larger number of affected cattle is needed to determine the advantages or disadvantages of this procedure over other surgical techniques. 1. 2. Baker JC , Smith JA . Disease of the pharynx, larynx and trachea . In: Smith BP , ed. Large animal internal medicine . 3rd ed. St Louis : Mosby Inc , 2002 ; 545 – 550 . Baker JC Smith JA . Disease of the pharynx, larynx and trachea . In: Smith BP , ed. Large animal internal medicine . 3rd ed. St Louis : Mosby Inc 3. Gasthuys F , Verschooten F , Parmentier D ,et al . Laryngotomy as a treatment for chronic laryngeal obstruction in cattle: a review of 130 cases . Vet Rec 1992 ; 130 : 220 – 223 . Crossref Gasthuys F Verschooten F Parmentier D , et al . Laryngotomy as a treatment for chronic laryngeal obstruction in cattle: a review of 130 cases ; 130 : 220 – 223 . 10.1136/vr.130.11.220 )| false Search Google Scholar 4. West HJ . Tracheolaryngostomy as a treatment for laryngeal obstruction in cattle . Vet J 1997 ; 153 : 81 – 86 . Crossref West HJ . Tracheolaryngostomy as a treatment for laryngeal obstruction in cattle . Vet J 1997 ; 153 : 81 – 86 . 10.1016/S1090-0233(97)80012-3 )| false 5. Goulding R , Schumacher J , Barret DC ,et al . Use of a permanent tracheostomy to treat laryngeal chondritis and stenosis in a heifer . Vet Rec 2003 ; 152 : 809 – 811 . Crossref Goulding R Schumacher J Barret DC , et al . Use of a permanent tracheostomy to treat laryngeal chondritis and stenosis in a heifer . Vet Rec 2003 ; 152 : 809 – 811 . 10.1136/vr.152.26.809 )| false 6. Milne MH , Barret DC , Sullivan M ,et al . Successful medical treatment of laryngeal chondritis in cattle . Vet Rec 2000 ; 147 : 305 – 306 . Crossref Milne MH Barret DC Sullivan M , et al . Successful medical treatment of laryngeal chondritis in cattle . Vet Rec 2000 ; 147 : 305 – 306 . 10.1136/vr.147.11.305 )| false 7. Belknap JK , Derksen FJ , Nickels FA ,et al . Failure of subtotal arytenoidectomy to improve upper airways flow mechanics in exercising standardbreds with induced laryngeal hemiplegia . Am J Vet Res 1990 ; 51 : 1481 – 1487 . Belknap JK Derksen FJ Crossref Williams JW Meagher DM Pascoe JR , et al . Upper airway function during maximal exercise in horses with obstructive upper airway lesions. Effect of surgical treatment . Vet Surg 1990 ; 19 : 142 – 147 . 10.1111/j.1532-950X.1990.tb01156.x )| false Search Google Scholar 12. Williams JW , Pascoe JR , Meagher DM ,et al . Effects of left recurrent laryngeal neurectomy, prosthetic laryngoplasty, and subtotal arytenoidectomy on upper airway pressure during maximal exertion . Vet Surg 1990 ; 19 : 136 – 141 . Crossref Williams JW Pascoe JR Meagher DM , et al . Effects of left recurrent laryngeal neurectomy, prosthetic laryngoplasty, and subtotal arytenoidectomy on upper airway pressure during maximal exertion . Vet Surg 1990 ; 19 : 136 – 141 . 10.1111/j.1532-950X.1990.tb01155.x )| false Search Google Scholar 13. Tulleners EP , Harrison IW , Mann P ,et al . Partial arytenoidectomy in the horse with and without mucosal closure . Vet Surg 1988 ; 17 : 252 – 257 . Crossref Tulleners EP Harrison IW Mann P , et al . Partial arytenoidectomy in the horse with and without mucosal closure . Vet Surg 1988 ; 17 : 252 – 257 . 10.1111/j.1532-950X.1988.tb01009.x )| false Search Google Scholar 14. Barnes AJ , Slone DE , Lynch TM . Performance after partial arytenoidectomy without mucosal closure in 27 Thouroughbred racehorses . Vet Surg 2004 ; 33 : 398 – 403 . Crossref Barnes AJ Slone DE Lynch TM . Performance after partial arytenoidectomy without mucosal closure in 27 Thouroughbred racehorses . Vet Surg 2004 ; 33 398 – 403 15. Boulton EP , Seeherman HJ , Kirker-Head CA ,et al . Primary closure of equine laryngotomy incisions: a review of 42 cases . Vet Surg 1995 ; 24 : 226 – 230 . Crossref Boulton EP Seeherman HJ Kirker-Head CA . Vet Surg Subtotal or partial unilateral arytenoidectomy for treatment of arytenoid chondritis in five calves Sylvain Nichols Sylvain Nichols Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210. Search for other papers by Sylvain Nichols in Current site Google Scholar PubMed Close DVM, MS, DACVS and David E. Anderson David E. Anderson Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506. Search for other papers by David E. Anderson in Current site Google Scholar PubMed Close DVM, MS, DACVS DOI: https://doi.org/10.2460/javma.235.4.420 Volume/Issue: Volume 235: Issue 4 Online Publication Date: 15 Aug 2009 Abstract Case Description—5 calves were evaluated for abnormal respiratory noise associated with variable degrees of respiratory distress. Clinical Findings—Tachypnea and inspiratory dyspnea were detected at initial evaluation in all calves. Endoscopic evaluation of the upper respiratory tract revealed enlarged and immobile arytenoids. Radiographic (n = 3) and computed tomographic (1) evaluation of the laryngeal area revealed images that were indicative of a large soft tissue mass at the level of the arytenoids obstructing the rima glottis. A presumptive diagnosis of arytenoid chondritis was made. Treatment and Outcome—A tracheostomy tube was placed in all calves. Medical treatment (with antimicrobials and anti-inflammatory drugs) was attempted in 4 calves after initial evaluation. Unilateral arytenoidectomy via a laryngotomy was performed under general anesthesia in all calves. Dysphagia and coughing were the most frequent postoperative complications. Three calves survived at least 6 months after the procedure. One calf died of a perforated abomasal ulcer 3 months after the surgery. Another calf died suddenly 1 month after the surgery of an undetermined cause. Clinical Relevance—Unilateral arytenoidectomy was a viable surgical treatment for arytenoid chondritis in calves. Further research in a larger number of affected cattle is needed to determine the advantages or disadvantages of this procedure over other surgical techniques. Abstract Case Description—5 calves were evaluated for abnormal respiratory noise associated with variable degrees of respiratory distress. Clinical Findings—Tachypnea and inspiratory dyspnea were detected at initial evaluation in all calves. Endoscopic evaluation of the upper respiratory tract revealed enlarged and immobile arytenoids. Radiographic (n = 3) and computed tomographic (1) evaluation of the laryngeal area revealed images that were indicative of a large soft tissue mass at the level of the arytenoids obstructing the rima glottis. A presumptive diagnosis of arytenoid chondritis was made. Treatment and Outcome—A tracheostomy tube was placed in all calves. Medical treatment (with antimicrobials and anti-inflammatory drugs) was attempted in 4 calves after initial evaluation. Unilateral arytenoidectomy via a laryngotomy was performed under general anesthesia in all calves. Dysphagia and coughing were the most frequent postoperative complications. Three calves survived at least 6 months after the procedure. One calf died of a perforated abomasal ulcer 3 months after the surgery. Another calf died suddenly 1 month after the surgery of an undetermined cause. Clinical Relevance—Unilateral arytenoidectomy was a viable surgical treatment for arytenoid chondritis in calves. Further research in a larger number of affected cattle is needed to determine the advantages or disadvantages of this procedure over other surgical techniques. Contributor Notes Dr. Nichols' present address is Faculté de Médecine Vétérinaire, University of Montréal, St-Hyacinthe, QC J2S 2M2, Canada. Address correspondence to Dr. Nichols. Journal of the American Veterinary Medical Association ISSN: 0003-1488 Publication Date: 15 Aug 2009 Headings Abstract Discussion References References 1. Stick JA . Larynx . In: Auer JA , Stick JA , eds. Equine surgery . 3rd ed. St Louis : Elsevier Inc , 2006 ; 578 – 581 . Stick JA . Larynx . In: Auer JA Stick JA , eds. Equine surgery . 3rd ed. St Louis : Elsevier Inc , 2006 ; 578 – 581 . )| false Search Google Scholar Export Citation 2. Baker JC , Smith JA . Disease of the pharynx, larynx and trachea . In: Smith BP , ed. Large animal internal medicine . 3rd ed. St Louis : Mosby Inc , 2002 ; 545 – 550 . Baker JC Smith JA . Disease of the pharynx, larynx and trachea . In: Smith BP , ed. Large animal internal medicine . 3rd ed. St Louis Barret DC Sullivan M , et al . Successful medical treatment of laryngeal chondritis in cattle . Vet Rec 2000 ; 147 : 305 – 306 . 10.1136/vr.147.11.305 )| false Search Google Scholar Belknap JK , Derksen FJ , Nickels FA ,et al . Failure of subtotal arytenoidectomy to improve upper airways flow mechanics in exercising standardbreds with induced laryngeal hemiplegia . Am J Vet Res 1990 ; 51 : 1481 – 1487 . Belknap JK Derksen FJ Nickels FA , et al . Failure of subtotal arytenoidectomy to improve upper airways flow mechanics in exercising standardbreds with induced laryngeal hemiplegia . Am J Vet Res 1990 ; 51 : 1481 – 1487 . Export Citation 8. Dean PW , Cohen ND . Arytenoidectomy for advanced unilateral chondropathy with accompanying lesions . Vet Surg 1990 ; 19 : 364 – 370 . Crossref Dean PW Cohen ND . Arytenoidectomy for advanced unilateral chondropathy with accompanying lesions . Vet Surg 1990 ; 19 : 364 – 370 . 10.1111/j.1532-950X.1990.tb01209.x Export Citation 9. Haynes PF , Snider TG , McClure JR ,et al . Chronic chondritis of the equine arytenoid cartilage . J Am Vet Med Assoc 1980 ; 177 : 1135 – 1142 . Haynes PF Snider TG McClure JR , et al . Chronic chondritis of the equine arytenoid cartilage . J Am Vet Med Assoc 1980 ; 177 : 1135 – Tulleners EP , Harrison IW , Raker CW . Management of arytenoid chondropathy and failed laryngoplasty in horses: 75 cases (1979–1985) . J Am Vet Med Assoc 1988 ; 192 : 670 – 675 . . Williams Pascoe JR Meagher Tulleners EP , Harrison IW , Mann P ,et al . Partial arytenoidectomy in the horse with and without mucosal closure . Vet Surg 1988 ; 17 : 252 – 257 . Tulleners EP
https://avmajournals.avma.org/abstract/journals/javma/235/4/javma.235.4.420.xml
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Applied Sciences | Free Full-Text | Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate The huge increase in production of construction and demolition waste (CDW) worldwide is leading to the valorisation of as recycled aggregates. One of the most promising alternatives is its use as a recycled aggregate in the manufacture of structural concrete, which motivates the study of the dynamic behaviour of these materials in order to ensure their suitability for use in elements subjected to dynamic loads. This work evaluated the resonant compressive fatigue behaviour of structural concretes with 25% or 50% recycled mixed aggregates, either individually or in combination with 25% recycled cement of clay-based materials both from CDW. All mixes were subjected to compressive fatigue tests using the accelerated Locati method. Regarding the fatigue limit, the results showed that for all mixes, it was between 30% and 45% of the compressive strength. In addition, a correlation was also found between the resonance frequency of the test and the deformation suffered by the specimen. This correlation enabled the estimation of the fatigue limit through a more stable parameter than the strain measured by strain gauges, namely, the resonance frequency. In addition, it was found that the resonance frequency of the test changed as the specimen damage increased. This observation enabled the estimation of the fatigue limit through a more stable parameter than the strain measured by strain gauges, namely, the resonance frequency. Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate by Blas Cantero 1 , Jose Sainz-Aja 2 , Adrian Yoris 2 , César Medina 1 and Carlos Thomas 2,* 1 2 LADICIM (Laboratory of Materials Science and Engineering), University of Cantabria, E.T.S. de Ingenieros de Caminos, Canales y Puertos, Av/Los Castros, 39005 Santander, Spain * Author to whom correspondence should be addressed. Appl. Sci. 2021 , 11 (11), 5045; https://doi.org/10.3390/app11115045 Received: 5 May 2021 / Revised: 26 May 2021 / Accepted: 27 May 2021 / Published: 29 May 2021 Abstract : The huge increase in production of construction and demolition waste (CDW) worldwide is leading to the valorisation of as recycled aggregates. One of the most promising alternatives is its use as a recycled aggregate in the manufacture of structural concrete, which motivates the study of the dynamic behaviour of these materials in order to ensure their suitability for use in elements subjected to dynamic loads. This work evaluated the resonant compressive fatigue behaviour of structural concretes with 25% or 50% recycled mixed aggregates, either individually or in combination with 25% recycled cement of clay-based materials both from CDW. All mixes were subjected to compressive fatigue tests using the accelerated Locati method. Regarding the fatigue limit, the results showed that for all mixes, it was between 30% and 45% of the compressive strength. In addition, a correlation was also found between the resonance frequency of the test and the deformation suffered by the specimen. This correlation enabled the estimation of the fatigue limit through a more stable parameter than the strain measured by strain gauges, namely, the resonance frequency. In addition, it was found that the resonance frequency of the test changed as the specimen damage increased. This observation enabled the estimation of the fatigue limit through a more stable parameter than the strain measured by strain gauges, namely, the resonance frequency. Keywords: recycled concrete ; resonant fatigue ; Locati method ; Concrete is the most widely used and versatile material in construction [ 1 ]. In 2019 ~27 Gt of concrete was consumed worldwide [ 2 ], requiring the production of ~19 Gt of natural aggregates (NA) and ~4.1 Gt of Portland cement [ 3 ]. With current urban growth expectations, it is estimated that these quantities could increase by as much as 25% by 2030 [ 4 ]. Meanwhile, this rapid development is leading to a huge increase in construction and demolition waste (CDW) generated during the construction, remodelling and demolition of buildings and infrastructure, currently representing the world’s major waste stream. Consequently, the construction industry must change its current linear “produce-use-dispose” growth model to a more circular growth commitment by adopting actions that ensure sustainable development for concrete without compromising the needs of future generations. In this context, many countries are promoting policies that include the circular economy model with the aim of prolonging the useful life of structures, reducing the consumption of natural resources and valorizing the waste generated [ 5 ]. To this end, the valorisation of CDW as recycled aggregates (RA) in the design of new concretes is an attractive technique that can bring great economic and environmental benefits, given the possibility of obtaining recycled concretes with good mechanical performance [ 6 , 7 , 8 ] and durability [ 9 , 10 , 11 , 12 ]. In this line, there are other works that attempt to assess CDW as RA together with new recycled supplementary cementitious material (SCM) (ground granulated blast fume [ 13 , 14 ], ceramics recycled [ 15 , 16 ], concrete recycled [ 17 , 18 ] and biomass waste [ 19 , 20 ]) as a partial substitute for cement, providing a double benefit by reducing the consumption of NA and cement, and achieving promising results in the improvement in mechanical and durability performance of concretes made only with CDW. At present, the fatigue process involving recycled concrete is as yet an inadequately investigated topic [ 21 ]. A deeper understanding of this structural behaviour is essential to promote the reincorporation of these new raw materials into the production cycles in the concrete industry. Fatigue in concrete can be defined as a process of mechanical degradation leading to failure. Due to cyclic loads, crack initiation and propagation within the specimen occur until final failure. However, during the application of the variable loads, a modification of the mechanical parameters of the concrete occurs, progressively varying the structural responses of an element [ 22 ]. This behaviour is of great importance in the design of structural elements, such as bridges, airport pavements, roads, marine structures, wind generators, foundations of industrial equipment, etc. Compared to permanent loads, these elements are subjected to a higher number of cyclic loads due to variable loads (transient loads, wind, etc.), and these cyclic loads produce a major reduction in mechanical properties, shortening the service life of this type of structure. Some researchers have focused their efforts on increasing knowledge about the compressive fatigue behaviour of this new generation of recycled concretes. In this area, Xiao et al. [ 23 ] studied the fatigue behaviour of concretes with 100% recycled coarse aggregates (RCA) (>95% waste concrete). For this purpose, they tested cylindrical specimens in cyclic uniaxial compression tests with a constant minimum fatigue load stress and a frequency of 10 Hz. These authors observed that concretes with 100% RCA showed fatigue behaviour in three different stages: (i) cyclic creep stage, (ii) creep coupling stage and (iii) fatigue stage, similar to the behaviour pattern of conventional concrete with NA [ 24 ]. Thomas et al. [ 25 , 26 ] carried out an extensive experimental programme (24 mixes) to study fatigue behaviour of concretes made with RCA (20%, 50% and 100%) and different effective water-cement (w/c) eff ratios (from 0.45 to 0.65). In their results, these authors reported that, for same (w/c) eff , RCA concretes showed a greater reduction in fatigue life than NA concretes. However, concretes with up to 20% RCA and (w/c) eff showed fatigue behaviour similar to that of NA concrete. In general, the reduced fatigue life of RCA concretes can be attributed to: (i) greater numbers of micro-cracks in the RCA produced in the crushing process of concrete waste, which are more easily interconnected as a result of cyclic loading [ 27 ] and (ii) larger interfacial transition zones between the cement paste and the RCA, which act as additional weak bonds under cyclic loading [ 28 ]. Sainz-Aja et al. [ 29 ] observed through microstructural analysis with computer microtomography of RCA concretes subjected to compressive fatigue loading that cracks are mostly generated at the aggregate interfacial transition zone (ITZ) and the edges of the flakier aggregates, propagating through the weaker planes until concrete collapse occurs. Breccolotti et al. [ 21 ] researched the experimental results of Xiao et al. [ 23 ] and Thomas et al. [ 26 ] in order to improve the understanding of the fatigue behaviour of concretes made with RCA. These authors were able to develop a predictive algorithm to estimate the fatigue behaviour of RCA concrete, knowing the compressive strength, the percentage of NA substitution by RCA and the type of concrete mix, obtaining good agreement between the experimental results and the theoretical prediction. Furthermore, these authors verified that the concretes with RCA complied with the fatigue life predictions calculated according to the Model Code 2010 [ 30 ]. Recently, Sainz-Aja et al. [ 31 ] combined the accelerated Locati fatigue method with 2 × 10 5 cycles per step with resonant fatigue, minimising the time and cost of fatigue testing. These authors observed more conservative results in the fatigue behaviour of concretes tested at moderate frequency (10 Hz) than in the case of those tested at high frequency (≈90 Hz), this effect being greater in concretes manufactured with RCA. Moreover, they observed an increase in temperature with increasing frequency, which could reduce the fatigue life of the concrete by increasing creep damage. From all the research carried out to date, great advances have been made in the knowledge of the fatigue behaviour of concrete with RCA. However, this type of recycled aggregate, in Spain only represents between 30% and 40% of CDW [ 32 ]. The remainder is represented by mixed recycled aggregates (MRA), the result of jointly crushing used concrete, masonry materials (brick, roof and ceramic tile) and some minor components, including plaster, wood, plastic and glass. MRA are more heterogeneous than RCA, which makes it more difficult to reincorporate them into the concrete production chain. Nevertheless, new scientific contributions are emerging every day that encourage further research in this field, motivated by the possibility of producing concretes with MRA with acceptable mechanical [ 6 , 32 , 33 , 34 ] and durability [ 10 , 35 , 36 , 37 ] results. Furthermore, according to the latest report of the European Commission [ 38 ], MRA are the biggest problem within CDW due to their accumulation in recycling plants. The recent review by Tang et al. [ 39 ] shows that the partial substitution of up to 30% by weight of recycled clay waste from CDW as SCM in the manufacture of concrete can improve, if the fineness of the waste is adequate, the properties of new concretes incorporating these new SCMs in the cement with respect to conventional concrete, as well as being an effective solution to mitigate the pollutant emissions associated with cement production, with a reduction of up to 8.1% of cement produced [ 40 ]. With this objective, the innovation of this research is to analyse the individual and joint effects of the incorporation of mixed recycled finely ground clay-based waste as SCM to cement (RPW-CDW) and the coarse fraction of mixed recycled aggregates in the study of resonant fatigue behaviour from structural concretes. It purposes to enhance the scientific and technical understanding of the combined use of such waste and contribute to its valorisation. In this context, there are still no research studies on this behaviour with these recycled materials. For this purpose, an experimental programme was designed to carry out resonant fatigue tests using the Locati method with 1 × 10 5 cycles per step. This technique allowed evaluating the fatigue limit of concretes made with MRA and concretes made with 25% RPW-CDW and (25–50%) MRA, finding that the resonance frequency decreases as the damage in the specimen increases. This observation allows estimating the fatigue limit through a more stable parameter than the strain measured by strain gauges, namely the resonance frequency. Finally, the results of this research will contribute to a better understanding of the resonant fatigue behaviour of this new generation of concretes with MRA and recycled cement from the integral recovery of CDW. 2. Materials and Methods 2.1. Materials 2.1.1. Binders The concretes were manufactured with two types of cement: (i) 100% Ordinary Portland cement (OPC), class 42.5 R according to EN 197-1 [ 41 ], without additions, supplied by Lafarge Holcim Cement, Toledo, Spain, and (ii) a recycled cement (OPC-25CDW) composed of 75% OPC and 25% recycled ceramic-based waste (bricks, tiles, blocks, etc.) from the crushing and grinding of CDW waste (RWP-CDW). Table 1 shows the chemical composition of RWP-CDW and the resulting OPC-25CDW. This cement is registered by patent Nº ES2512065 [ 42 ] and can be classified as CEM II/B or CEM IV/A of strength class 42.5 MPa according to EN 197-1 [ 41 ]. Similarly, a water-based modified polycarboxylate superplasticiser (SP) admixture with a density of 1.1 g/cm 3 and a solids’ content of 20% from BRYTEN NF furnished by FUCHS Lubricantes was used. 2.1.2. Aggregates The crushed greywacke natural aggregate used comprised three particle sizes: 0 mm to 6 mm (NA-S), 6 mm to 12 mm (NA-M) and 12 mm to 22 (NA-C). The recycled aggregate used, which was supplied by a CDW processing plant located in the Spanish region of Extremadura, had two particle size fractions: 6 mm to 12 mm (MRA-M) and 12 mm to 22 mm (MRA-C). The composition analysis of recycled aggregates ( Table 2 ), conducted as specified in standard EN 933-11 [ 43 ], revealed that the main components were concrete and mortar (47.0–44.0 wt%), ceramic (7.2–10.9 wt%) and natural stone (44.8–43.8 wt%), with others (glass and metals) (<0.5 wt%) as minor constituents. On the grounds of these data and the criteria set out in Spain’s structural concrete code [ 44 ] with its <95 wt% Rcu (Rcu = Rc + Ru) content and >5 wt% Rb content, MRA-M and MRA-G qualified for classification as a mixed recycled aggregate. The particle size distribution and the physical and mechanical properties of all the aggregates used to prepare the concrete mixed are listed in Figure 1 and Table 3 , respectively. Due primarily to their higher porosity, the recycled aggregates had a lower density than the natural materials in all particle sizes. The saturated surface dry density was found to lie in the 2.42 Mg/m 3 to 2.45 Mg/m 3 range. These aggregates also absorbed more water than the NA, a consequence of the adhered mortar and masonry particles present in the new materials, which exhibited absorption percentages within the range of 4.0 to 10% observed by other authors [ 7 , 17 , 32 ] for this type of recycled aggregates. As the adhered mortar tended to smooth its sharpest angles, RA had a lower flakiness index than NA. The recycled materials had a higher Los Angeles coefficient than the NA, likewise due to the adhered mortar and the presence of masonry. Here also, the values ranged within the 20 to 40% reported in the literature for recycled aggregate [ 16 , 33 , 45 ]. Finally, these recycled aggregates complied with the requirements set out in the European standard EN 12620 [ 46 ] for use as recycled aggregate in concrete. 2.2. Experimental Procedure Table 4 shows the 6 mixes used: a reference concrete (OPC + NA), a concrete with OPC-25CDW and NA, two concretes with OPC with 25% and 50% MRA each and two concretes with OPC-25CDW with 25% and 50% MRA replacement each. Cylindrical specimens of 100 mm diameter and 200 mm height were manufactured according to EN 12390-1 [ 50 ] for the resonant fatigue tests. These specimens were demoulded after 24 h and cured at 95 ± 5% relative humidity and a constant 20 ± 2 °C until 180 days of curing. Uniaxial compressive strength according to EN 12390-3 [ 51 ] and modulus of elasticity according to EN 12390-13 [ 52 ] were also determined. 2.2.1. Resonant Fatigue Test Resonant fatigue is a technique that allows fatigue testing at the resonant frequency of the system. This resonant frequency depends on the stiffness of the system, and, in the case of concrete, the stiffness is highly dependent on both the load values between which it is being calculated and the degree of cracking of the specimens. The concrete’s compressive resonant fatigue behaviour was studied using the Locati method, which enabled the estimation of the fatigue limit using a single specimen. For this purpose, the minimum stress value (σ 0 ), corresponding to the lower limit, was fixed, and the upper limit of the maximum stress range (σ j ) was varied in steps, where j represents the different steps. Six loading steps with 1 × 10 5 cycles each were established, and a sinusoidal wave was applied at resonance by means of load control. The specimens were instrumented with two 60 mm strain gauges to measure the strains. These were placed diametrically opposite to the central axis of the specimen and centred in height, and bonded with two-component epoxy resin. The strains recorded in both gauges were averaged for the calculations. The test programme for the determination of the resonant fatigue limits is shown in detail in Table 5 . Based on the uniaxial compressive strengths ( f cd,180 ) of the set of specimens, the minimum stress, σ min , was defined as 2.5 MPa and the maximum initial stress, σ max , as 12.5 MPa, and an increase, Δ, in the maximum stresses of 5.0 MPa was considered in each successive step. The fatigue limit was established from Equation (1), which was determined by correlating tests on different types of concrete by applying the Locati and Staircase methods [ 53 ]. L F = 0.8 ∗ L (1) where L F is the fatigue limit (MPa) and Δ σ L is the stress range of the Locati test rupture step (MPa). In addition, the influence coefficient ( IC ) was defined as the ratio of the fatigue limit to the compressive strength in percent. The resonance frequency tests were carried out with the Zwick/Roell Amsler 400 HFP 5100 Vibrophores ( Figure 2 ), which have a maximum load capacity of 400 kN, maximum mean load of ±300 kN, maximum force amplitude of ±200 kN, and a test frequency range between 35 Hz and 300 Hz. 2.2.2. Post-Processing Experimental Results During the fatigue tests, a data acquisition system was programmed to periodically record blocks of 0.03 seconds’ duration of the force applied by the resonance machine and the strain recorded by each of the two strain gauges attached to the specimens. In this work, post-processing tasks were carried out to facilitate the interpretation of the results obtained. Specifically, a one degree Fourier regression [ 54 , 55 , 56 ] was performed to enable the fitting of the data to a harmonic function (2) [ 56 ]: y ( t ) = a 0 + a 1 ∗ c o s ( w ∗ t ) + b 1 ∗ s i n ( w ∗ t ) (2) where a 0 , a 1 and b 1 are regression parameters and w is the angular frequency. This equation can be transformed into a typical sinusoidal Equation (3) by using the following relationships (4) [ 56 ]: y ( t ) = y 0 + A ∗ sin ( w ∗ t + φ 0 ) (3) y 0 = a 0 ; A = a 1 2 + b 1 2 ; φ 0 = π 2 − a r c t a n 1 a 1 ) (4) where y 0 is the vertical offset, A is the amplitude and φ 0 is the phase shift of the sinusoidal wave. Moreover, the angular frequency and the testing frequency are related by the following Equation (5) [ 56 ]: w = 2 ∗ f ∗ φ 0 (5) Figure 3 shows an example comparing the results acquired by raw data (discrete points) and the regression obtained (continuous function). 2.2.3. Mix Design Batching for all the concrete mixes is given in Table 6 . All mixes, irrespective of the MRA and/or NA content, were designed with the British mix approach [ 57 ], using the following starting conditions: (i) concrete compressive strength at 28 days, in 150 mm diameter and 300 mm height specimens, f ck = 30 MPa; (ii) cement strength class, 42.5 R; (iii) effective w/c ratio: 0.45; and (iv) aggregate with a maximum size of 20 mm. The natural moisture content of all aggregates at the time of manufacture of the mixes and the water absorption were also considered. The concretes were prepared in the laboratory as follows: coarse and fine aggregates were mixed for 30 s, then cement was added and mixed for 60 s to homogenise the mixture. The additive was dissolved in 10% of the total water content and mixed with the solids for 45 s. With the mixer running, 70% of the total volume of water was added and mixed for 120 s, after which the remaining 20% of the water was added and mixed for 240 s. The mixer was then switched off, the fresh properties were determined and the mixture was poured into the respective moulds, according to the European standard (EN 12390-1) [ 50 ]. Figure 4 shows the modulus of elasticity of the different mixes [ 16 ]. 3. Results and Discussion 3.1. Fatigue Limit Table 7 shows the values obtained from the Locati resonant fatigue tests for all mixes. In addition, to complement this parameter, the values of f cd,180 ( Table 6 ) and IC were added, which enabled the evaluation of the effect of fatigue on each type of concrete. In all cases, fatigue reduced the strength of the specimens to between 30 and 45% of the f cd,180 . Regarding the effect of the presence of both MRA and OPC-25CDW on the IC , there seemed to be no clear effect. This can be explained mainly by the high dispersion associated with fatigue failure, as this parameter is highly influenced by local phenomena. Furthermore, analysing the strength properties of concrete [ 15 ], neither the presence of MRA nor OPC-25CDW produced a significant change in the strength of the material. The little influence of MRA and OPC-25CDW on the IC is because, as pointed out by Lantsoght et al. [ 58 ], the fatigue strength of a recycled concrete does not depend only on the presence of RA, but also depends to a large extent on water/cement ratio, cement content, concrete type, rest periods, curing conditions and age during loading, and in this case, it was concrete with a high cement content per cubic metre and with high-quality MRA [ 16 ]. Furthermore, because the method used for the determination of the fatigue limit was based on a test that applies load steps, the resolution of this method will be similar to the size of the steps used. Therefore, if the differences between mixtures were smaller than the step size, they will be masked by the resolution of the test. 3.2. Strain Evolution Test Figure 5 and Figure 6 show the evolution of the strain amplitude of the two series of six mixes analysed during the accelerated fatigue test. Figure 4 shows the results corresponding to the OPC mix, and Figure 5 shows the results corresponding to the OPC-25CDW mix. It can be observed that the presence of MRA increased the strain amplitude recorded for both OPC and OPC-25CDW concretes. This increase in the strain of the concrete with MRA could also be observed in the static tests if we compared the elastic modulus of the different mixes. These results are in agreement with those observed by other authors who have performed fatigue tests on RA concrete analysing the strain evolution [ 23 , 24 , 25 , 26 , 29 , 31 ]. On the other hand, the influence of the type of cement on the strain of the specimens during the fatigue tests was much lower; this effect is also in agreement with the static values obtained in the elastic modulus tests [ 16 ]. From Figure 4 and Figure 5 , it can also be seen that the presence of MRA resulted in less homogeneous results, which is in agreement with other research [ 17 , 59 ]. In view of the results, which showed both equivalent compressive strength and fatigue strength for both conventional and recycled concretes, it could be considered to use these concretes for the main applications that are susceptible to fatigue damage, such as the railway superstructure, sleepers, or tracks, bridges both for railroad and for road traffic, offshore structures subjected to wind and sea waves and/or wind power tower. Nevertheless, it should be noted that lower modulus results were obtained, which should be taken into account, especially in applications where the concrete is prestressed. 3.3. Frequency Evolution Figure 7 shows an example of the evolution of the resonant frequency of the set during the fatigue test as a function of the number of cycles. The fatigue testing machine used is characterised by always testing at the resonance frequency of the test machine and specimen assembly, which depends mainly on the stiffness of the assembly; the stiffer it is, the higher the resonance frequency. As shown in this figure, the resonance frequency was not constant throughout the test, which implied that the specimen underwent a series of changes in its mechanical properties during the test. First, it can be seen that when each time a step change occurred, there was also an increase in the resonance frequency. This is because a step-change implies an increase in the stress range applied to the specimen, which generally results in a higher stiffness. Second, it can be seen that, after the first few cycles, there was a reduction in the resonance frequency, corresponding to a stabilisation phase. In the fourth step, this effect was not seen because it is a phenomenon of short duration, which only affects a few cycles, and the data acquisition did not record any of them. However, it is a phenomenon observed by other authors [ 29 , 31 ]. In the first step, it can be seen that, once this first phase was overcome, the resonance frequency remained constant, which means that the specimen was in a stationary state, i.e., the specimen was suffering little damage, and, therefore, it could withstand a large number of cycles without breaking. It was only in the last step that the resonance frequency decreased. This drop in frequency was the consequence of an increase in the specimen deformation, which can be explained by the growth of micro-cracks in the concrete specimen that will lead to specimen failure [ 60 ]. For this reason, observing that the resonance frequency decreased (after the initial stabilisation phase) is considered as an indicator of being close to failure of the specimen and that the endurance of the material has been exceeded. Finally, this methodology may be a new way to measure the fatigue limit through resonance frequency monitoring. Figure 8 and Figure 9 show an example of the comparison between the test frequencies obtained for each type of concrete as a function of the percentage of NA replaced by MRA for each type of cement. Figure 7 shows the results for the OPC concretes. It can be seen that the behavioural phases described above were satisfied. As the percentage of replacement increased, the resonance frequency decreased, decreasing the stiffness of the specimen, which was in agreement with the results obtained from the elastic modulus tests and with the strain values previously shown. Figure 8 shows the results of the mixes with OPC-25CDW. As in the case of Figure 7 , the phases described above can be seen. In these mixes, it was also observed that in those concretes with MRA, the resonance frequencies were lower than in the case of concretes without MRA. Likewise, these values agreed with the results obtained in the elastic modulus and strain tests. 3.4. Correlation between Strain and Frequency during a Resonance Fatigue Test In the two previous sections, the evolution of the strain amplitude and the resonance frequency was shown, and it was commented that there is a relationship between the two parameters. Figure 10 shows an example of a comparison between the two parameters for the same test. Figure 10 show that both parameters suffer abrupt changes at the beginning of each step. In phases where one parameter remained constant, the other also remained constant, although the frequency values seemed to be more stable than the strain values. In phases where changes occurred within the same step, i.e., where the loads remained constant, the effect of the deterioration of the specimens was the inverse for each of these parameters, the frequency decreased and strain increased. At step changes, both parameters underwent punctual increases, while within each step, the change undergone by each parameter was the inverse; this was due to the modifications of the applied stress values. As the applied load amplitude increased, the specimen strained more, and the ratio between force and strain (stiffness) also increased at each step. However, within the same step, as the displacement amplitude increased, the stiffness decreased. To analyse the ratio between load and strain, Figure 11 shows an example of the evolution of a parameter correlated with stiffness, namely the elastic modulus, during a fatigue test. Figure 11 shows how, contrary to strain amplitude or resonance frequency, the elastic modulus was a parameter that had a continuous behaviour, if we do not take into account the stabilisation period at the beginning of a step. Moreover, it is a parameter that always decreased [ 23 , 24 , 25 , 61 ]. This is because as the specimen is damaged, the micro-cracks present in the concrete grow, which results in a lower elastic modulus. 3.5. Morphological Analysis of Fractures Figure 12 shows examples of the failure surfaces of the six types of concretes evaluated in this work. On the left the series of mixes with OPC. On the right, the series of mixes with OPC-25CDW. Comparing the failure surfaces of those concretes with different degrees of replacement of NA by MRA, different failure mechanisms were observed, similar to those observed by other authors who also performed fatigue tests on concrete [ 26 , 61 ]. In Figure 12 , the following patterns were observed on the fracture surfaces of specimens incorporating NA: paste planes were seen, which before fatigue were in contact with aggregates; cracks were seen at the edges of some aggregates; pieces of aggregate were seen protruding above the fracture surface. Figure 13 b shows a detail of the fracture surface of a specimen with MRA. In this figure, the following patterns can be seen: (i) in the case of aggregates from structural concrete, it can be seen that the fracture surface had generated a plane through the aggregate and (ii) in the case of an aggregate of ceramic origin, it can be seen that this aggregate had been pulverized. Several authors have concluded that the cracking of the specimens occurs because the cracks propagate through the weaker planes [ 62 , 63 , 64 , 65 ]. Based on the previously mentioned observations, it is possible to ensure that in those concretes with 0% replacement, and the cracks occur through the paste–aggregate interface (ITZ), i.e., the weakest zone of the specimens is the paste–aggregate interface. It can also be seen that the presence of MRA, especially in those of ceramic origin, can cause the rupture not to occur through the ITZ, because the aggregates have lower mechanical properties so that cracks can advance through them. On the fracture surface of the fatigue-tested specimens, no different fracture mechanisms were observed in relation to the use of different binders, OPC-25CDW or OPC. It can be observed that the paste had a different colour. It should be noted that, based on the colour of the paste of the concrete with OPC-25CDW, it was possible to estimate that the specimen was “very dry”, which is in agreement with what was observed once the test was completed, where the specimens were at a high temperature. This temperature increase has also been detected in other resonant fatigue studies on concrete [ 29 ]. 4. Conclusions The main conclusions derived from this research are: In the mixtures studied, the resonant fatigue limit was between 30 and 45% of the compressive strength. The fatigue results had a large scatter, and no direct influence on the resonant compressive fatigue limit was observed due to the presence of mix recycled aggregate. The presence of mixed recycled aggregates in the concretes increased the strain recorded during the resonance compressive fatigue tests. The presence of recycled cement did not affect the strain values. The resonance frequencies were lower in the concretes with MRA because the stiffness of the system provided by the presence of MRA increased the strain suffered by the specimen. For all cases, it was observed that during resonance fatigue tests with constant load cycles, as the strain increased, the resonance frequency decreased. In the compressive resonance fatigue tests, the unmixed MRA specimens exhibited fracture planes across the paste–aggregate interface. While the specimens with MRA showed cracks through the recycled concrete aggregates and pulverisation of the ceramic fractions. The strength of all the concretes was similar. The presence of mixed recycled aggregates had a greater effect on the dynamic response (increased strain and decreased resonance frequency) than the presence of recycled cement, which did not show any influence on the dynamic response. The characterisation in resonant fatigue allowed a reduction in test durations and the comparison of the fatigue life of different types of recycled concrete, even with recycled cement. However, the dispersion obtained in the results suggests that the more heterogeneous concretes are more sensitive to resonant fatigue. For this reason, for recycled concretes, the method does not seem directly comparable with the classical methods of static characterisation. Author Contributions A.Y. and B.C. performed the experiments; J.S.-A., A.Y. and B.C. analysed the data and wrote the paper; C.T. and C.M. supervised the research work and revised the paper. All the authors contributed to the experiment design and analysed and discussed the findings. All authors have read and agreed to the published version of the manuscript. Funding This research was funded by the Spanish Ministry of Science and Innovation within the framework of the project BIA 2013-48876-C3-2-R. Institutional Review Board Statement Not applicable. Informed Consent Statement Not applicable. Data Availability Statement Data sharing not applicable. Acknowledgments The first author benefited from the Ministry of Education, Culture and Sport’s pre-doctoral grant FPU16/02693. 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Example of the correlation between the recorded data and fitting values. Figure 3. Example of the correlation between the recorded data and fitting values. Figure 4. Modulus of elasticity of the different mixes. Figure 4. Modulus of elasticity of the different mixes. Figure 5. Strain amplitude evolution during a Locati test on the OPC mixes. Figure 5. Strain amplitude evolution during a Locati test on the OPC mixes. Figure 6. Strain amplitude evolution during a Locati test on the OPC-25CDW mixes. Figure 6. Strain amplitude evolution during a Locati test on the OPC-25CDW mixes. Figure 7. Resonance fatigue frequency evolution during a Locati test. Figure 7. Resonance fatigue frequency evolution during a Locati test. Figure 8. Resonance fatigue frequency evolution during a Locati test for OPC mixes. Figure 8. Resonance fatigue frequency evolution during a Locati test for OPC mixes. Figure 9. Resonance fatigue frequency evolution during a Locati test for OPC-25CDW mixes. Figure 9. Resonance fatigue frequency evolution during a Locati test for OPC-25CDW mixes. Figure 10. Comparison of the strain amplitude and the resonance frequency during a Locati fatigue test. Figure 10. Comparison of the strain amplitude and the resonance frequency during a Locati fatigue test. Figure 11. Modulus of elasticity evolution during a Locati test. Figure 11. Modulus of elasticity evolution during a Locati test. Figure 12. Fracture surface of samples broken during fatigue tests. Figure 12. Fracture surface of samples broken during fatigue tests. Figure 13. Fracture surface detail of samples broken during fatigue tests: HP sample ( a ) and HR-50 sample ( b ). Figure 13. Fracture surface detail of samples broken during fatigue tests: HP sample ( a ) and HR-50 sample ( b ). Table 1. Chemical composition of RWP-CDW and OPC-25CDW XRF analysis. Table 1. Chemical composition of RWP-CDW and OPC-25CDW XRF analysis. Material Chemical Composition (%wt.) LOI SiO 2 Al 2 O 3 Fe 2 O 3 CaO MgO SO 3 Na 2 O K 2 O TiO 2 P 2 O 5 Cl- SiO 2 (1) OPC 20.00 6.03 2.57 60.00 1.75 3.90 0.56 1.49 0.15 0.15 0.02 - 3.26 RWP-CDW 59.63 18.51 5.92 4.78 3.08 0.42 0.70 3.58 - - - 35.10 2.15 OPC-25CDW 31.30 8.26 3.24 48.99 2.86 2.43 0.51 1.58 0.35 0.19 0.04 - 2.66 Note: (1) Reactive. Table 2. Composition of recycled aggregates. Table 2. Composition of recycled aggregates. Composition (wt%) MRA-M MRA-G Ceramic 7.2 10.9 Concrete and mortar 47.0 44.0 Natural stone 44.8 43.8 Bituminous 0.6 0.9 Others 0.4 0.4 Note: MRA-M: mixed medium recycled aggregate (6/12 mm); MRA-G: mixed gravel recycled aggregate (4/22 mm). Table 3. Physical properties of aggregates. Table 3. Physical properties of aggregates. Property Aggregates NA-S NA-M NA-C MRA-M MRA-G EN 12620 Dry density (g/cm 3 ) [ 47 ] 2.73 2.71 2.72 2.28 2.32 - SSD (1) density (g/cm 3 ) [ 47 ] 2.76 2.74 2.74 2.42 2.45 - Water absorption 24 h (%wt.) [ 47 ] 1.18 0.88 0.78 6.28 5.27 ≤5 (≤7) (3) Open Porosity (vol%) [ 47 ] 3.2 2.4 1.9 14.3 12.2 Los Angeles coefficient (%wt.) [ 48 ] - 16 18 32 36 <50 (2) Flakiness index (%wt.) [ 49 ] - 21 25 10 10 <35 Note: (1) SSD: Saturated Surface Dry. (2) Concretes with a compressive strength of less than 30 MPa. (3) Mixture of recycled aggregate and natural aggregate. Table 4. Identification of manufactured concrete. Table 4. Identification of manufactured concrete. Table 5. Fatigue test parameters by the Locati method. Table 5. Fatigue test parameters by the Locati method. Step j Cycle N σ min -σ 0 [MPa] σ max -σ j [MPa] Δ [MPa] σ med [MPa] Amplitude [MPa] 1 0–1 × 10 5 2.5 12.5 5.0 7.5 5.0 2 1 × 10 5 –2 × 10 5 2.5 17.5 5.0 10.0 7.5 3 2 × 10 5 –3 × 10 5 2.5 22.5 5.0 12.5 10.0 4 3 × 10 5 –4 × 10 5 2.5 27.5 5.0 15.0 12.5 5 4 × 10 5 –5 × 10 5 2.5 32.5 5.0 17.5 15.0 6 5 × 10 5 –6 × 10 5 2.5 37.5 5.0 20.0 17.5 Table 6. Concrete mix proportions. Table 6. Concrete mix proportions. Material [kg/m 3 ] Type HP HR-25 HR-50 HP-R HRR-25 HRR-50 NA-S 732.36 720.79 705.38 732.36 720.79 705.38 NA-M 382.96 282.69 184.43 382.96 282.69 184.43 NA-G 766.69 565.94 369.22 766.69 565.94 369.22 MRA-M - 90.75 177.62 - 90.75 177.62 MRA-G - 182.80 357.77 - 182.80 357.77 OPC 400 400 400 - - - OPC-25CDW - - - 400 400 400 W 193.03 202.08 210.63 193.03 202.08 210.63 SP 6.20 6.20 6.20 6.20 6.20 6.20 (w/c) effective 0.48 0.50 0.53 0.48 0.50 0.53 Physical and mechanical properties ρ (kg/m 3 ) 2340 2310 2290 2350 2310 2240 f cd,180 (MPa) 53.5 47.0 48.8 50.2 47.5 47.5 Note: ρ , hardened density and f cm , compressive strength. Table 7. Fatigue limit obtained from Locati Method. Table 7. Fatigue limit obtained from Locati Method. Material f cd,180 [MPa] Δ σ L [MPa] L F [MPa] IC [%] HP 53.5 27.5 22.0 41.12 HR25 47.0 18.4 14.8 31.49 HR50 48.8 27.5 22.0 45.08 HRR 50.2 25.3 20.3 40.44 HRR25 47.5 27.5 22.0 46.32 HRR50 47.5 20.6 16.5 34.74 Note: f cd,180 : uniaxial compressive strength at 180 days; Δ σ L : stress range of the Locati test rupture step; L F : fatigue limit; IC : Influence coefficient ( L f /f cd,180 100). Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. MDPI and ACS Style Cantero, B.; Sainz-Aja, J.; Yoris, A.; Medina, C.; Thomas, C. Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate. Appl. Sci. 2021, 11, 5045. https://doi.org/10.3390/app11115045 AMA Style Cantero B, Sainz-Aja J, Yoris A, Medina C, Thomas C. Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate. Applied Sciences. 2021; 11(11):5045. https://doi.org/10.3390/app11115045 Chicago/Turabian Style Cantero, Blas, Jose Sainz-Aja, Adrian Yoris, César Medina, and Carlos Thomas. 2021. "Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate" Applied Sciences11, no. 11: 5045. https://doi.org/10.3390/app11115045 Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here . Article Metrics Cantero, B.; Sainz-Aja, J.; Yoris, A.; Medina, C.; Thomas, C. Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate. Appl. Sci. 2021, 11, 5045. https://doi.org/10.3390/app11115045 AMA Style Cantero B, Sainz-Aja J, Yoris A, Medina C, Thomas C. Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate. Applied Sciences. 2021; 11(11):5045. https://doi.org/10.3390/app11115045 Chicago/Turabian Style Cantero, Blas, Jose Sainz-Aja, Adrian Yoris, César Medina, and Carlos Thomas. 2021. "Resonance Fatigue Behaviour of Concretes with Recycled Cement and Aggregate" Applied Sciences11, no. 11: 5045. https://doi.org/10.3390/app11115045
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ABSTRACTS: January 2005 - technology.matthey.com ABSTRACTS: January 2005 PDF 231 KB Journal Archive Platinum Metals Rev., 2005, 49 , (1), 54 doi: 10.1595/147106705X25651 ABSTRACTS: January 2005 of current literature on the platinum metals and their alloys MIX PROPERTIES Determination of Diffusion Coefficient of Hydrogen in Metals and Their Elastic Modulus by Generalised Impedance P. ZOLTOWSKIand B. LEGAWIEC, J. Electroanal. Chem., 2004,572, (2), 205-210 LINKdoi:10.1016/j.jelechem.2003.05.001http://dx.doi.org/10.1016/j.jelechem.2003.05.001 Transport of H in elastic metals has been analysed in terms of an impedance-like non-linear transfer function (TF). The equilibrium in a membrane was perturbed by application of a sinusoidal signal of concentrations of H, of large amplitude, to a surface. The fundamental harmonics of periodically reproducible flux at this surface is considered as the response. The TF is defined as the ratio of the signal to the response. The TF was used in determining the diffusion coefficient of H in α-phase Pd-H and Pd 81Pt 19-H, and their bulk elastic moduli. Gas Loading of Deuterium in Palladium at Low Temperature F. SCARAMUZZI, J. Alloys Compd., 2004,385, (1-2), 19-27 LINKdoi:10.1016/j.jallcom.2004.04.136http://dx.doi.org/10.1016/j.jallcom.2004.04.136 An experimental technique that can be used to measure the absorption of H or D gas in a thin Pd sample (1) at low temperature is described. For D, the results consisted of measurements of the equilibrium loading ratio, X, as a function of pressure, on (1) 3.6 μm thick at 150 K. Values of X≤ 1 were measured at pressures of < 1 bar. The electrical resistance of (1) was measured as function of temperature and X. Effect of Hydrogen on the Electrical Resistance of Melt-Spun Mg 90 Pd 10 Amorphous Alloy S. NAKANO, S. YAMAURA, S. UCHINASHI, H. KIMURAand A. INOUE, Sens. Actuators B: Chem., 2005,104, (1), 75-79 LINKdoi:10.1016/j.snb.2004.04.101http://dx.doi.org/10.1016/j.snb.2004.04.101 The electrical resistance of the title alloy (1) increased after electrochemical H charging and decreased after H discharging in 6 N KOH solution. The electrical resistance of (1) immersed in H-dissolved H 2O increased with immersion time and the increase was dependent on the H concentration in the H 2O. (1) may find use as a H sensor in H 2O. CHEMICAL COMPOUNDS A High-Pressure and High-Temperature Synthesis of Platinum Carbide S. ONO, T. KIKEGAWAand Y. OHISHI, Solid State Commun., 2005,133, (1), 55-59 LINKdoi:10.1016/j.ssc.2004.09.048http://dx.doi.org/10.1016/j.ssc.2004.09.048 Pt carbide (1) was synthesised using high pressure and high temperature in a laser-heated diamond anvil cell. (1) has a rock-salt type structure, with space group Fm3mand cubic symmetry. (1) remains stable to ≤ 120 GPa. After decompression, the new high-pressure phase was recoverable at ambient pressure. Cyclometalated Tridentate C-N-N Ligands with an Amine or Amido Donor in Platinum(II) and Palladium(II) Complexes and a Novel Potassium Alkoxide Aggregate D. SONGand R. H. MORRIS, Organometallics, 2004,23, (19), 4406-4413 LINKdoi:10.1021/om0496232http://dx.doi.org/10.1021/om0496232 2-Phenyl-6-(2-aminoisopropyl)pyridine (papH 2) was used to prepare Pt(papH)Cl (1) and Pd(papH)Cl. In both complexes the κ 3N,N,C tridentate papH formed two five-membered rings with the metal, one of which was created by cyclometallation of the orthoC of the phenyl group. (1) reacted with KOBu to give [Pt(pap)] 2(KCl)(KO tBu) 8(2). The novel structure of (2) involves two Pt(pap) moieties being attached to the K 9O 8Cl "core" of the K alkoxide aggregate. Purine-Based Carbenes at Rhodium and Iridium J. SCHÜTZand W. A. HERRMANN, J. Organomet. Chem., 2004,689, (19), 2995-2999 LINKdoi:10.1016/j.jorganchem.2004.06.037http://dx.doi.org/10.1016/j.jorganchem.2004.06.037 Purine-based carbenes were attached to Rh and Ir through the in situdeprotonation of the respective azolium salts. Trimethyloxonium tetrafluoroborate was reacted with caffeine to give 1,3,7,9-tetramethylxanthinium tetrafluoroborate. The salt and 7,9-dimethylhypoxanthinium iodide were used as a consecutive precursor to form Rh (I) and Ir (I) carbenes, [M(L)(L Carbene) 2]I and M(L)(L Carbene)(I) (where M = Rh, Ir; L Carbene= 1,3,7,9-tetramethylxanthine-8-ylidene, 7,9-tetramethylhypoxanthine-8-ylidene; L = η 4-1,5-COD, CO). On the Silicides EuIr 2 Si 2 and Lu 5 Si 3 U. CH. RODEWALD, B. HEYING, D. JOHRENDTand R. PÖTTGEN, Z. Naturforsch., 2004,59b, (9), 969-974 EuIr 2Si 2(1) was synthesised from the elements in a sealed Ta tube in a H 2O-cooled sample chamber of an induction furnace. Lu 5Si 3was obtained by arc-melting of the elements. The Ir and Si atoms in (1) build up a 3D [Ir 2Si 2] network with Ir-Si and Si-Si interactions. The Eu atoms fill cages within the network. High-Pressure Synthesis of Metallic Perovskite Ruthenate CaCu 3 Ga 2 Ru 2 O 12 S.-H. BYEON, S.-S. LEE, J. B. PARISE, P. M. WOODWARDand N. H. HUR, Chem. Mater., 2004,16, (19), 3697-3701 LINKdoi:10.1021/cm049265thttp://dx.doi.org/10.1021/cm049265t CaCu 3Ga 2Ru 2O 12(1) was synthesised at 12.5 GPa and 1200ºC and recovered to room pressure and temperature conditions. In (1) the Ga and Ru cations in the perovskite-like structure are disordered over the octahedral sites. Magnetic susceptibility (at 5-300 K in an applied magnetic field of 5 kG) and electrical resistivity (at 10-400 K) measurements showed that (1) is a Pauli-paramagnetic conductor. (1) shows metallic conductivity in a perovskite-type oxide that contains the Ru(V) oxidation state. ELECTROCHEMISTRY Electrochemical Quartz Crystal Nanobalance to Detect Solvent Displacement by pH-Induced Conformational Changes of Proteins at Pt N. P. COSMANand S. G. ROSCOE, Anal. Chem., 2004,76, (19), 5945-5952 LINKdoi:10.1021/ac049517+http://dx.doi.org/10.1021/ac049517+ The adsorption behaviour of the proteins holo- and apo-α-lactalbumin at a Pt electrode (1) was studied in electrolyte solutions of pH < 2, 7.4 and 11 at 298 K. Electrochemical quartz crystal nanobalance frequency measurements gave a measure of nanogram changes on (1) due to solvent displacement by the adsorbed protein. Simultaneous CV charge transfer measurements gave protein surface concentration. Solvent Effects on Charge Transport through Solid Deposits of [Os(4,4 ' -diphenyl-2,2 ' -dipyridyl) 2 Cl 2 ] R. J. FORSTER, J. IQBAL, J. HJELMand T. E. KEYES, Analyst, 2004,129, (12), 1186-1192 LINKdoi:10.1039/b414814bhttp://dx.doi.org/10.1039/b414814b Mechanically attached, solid-state films (1) of the title complex were formed on Au macro- and microelectrodes. The voltammetric response of (1) associated with the Os 2+/3+redox reaction is similar of that observed for an ideal reversible, solution phase redox couple when the contacting electrolyte contains 40% v/v of MeCN. Preferential solvation of the redox centres by MeCN allows the incorporation of charge compensating counterions. PHOTOCONVERSION Triplet Exciton Diffusion and Delayed Interfacial Charge Separation in a TiO 2 /PdTPPC Bilayer: Monte Carlo Simulations J. E. KROEZE, T. J. SAVENIJE, L. P. CANDEIAS, J. M. WARMANand L. D. A. SIEBBELES, Sol. Energy Mater. Sol. Cells, 2005,85, (2), 189-203 LINKdoi:10.1016/j.solmat.2004.04.015http://dx.doi.org/10.1016/j.solmat.2004.04.015 Nanosecond photoexcitation of a bilayer of anatase TiO 2coated with Pd tetrakis(4-carboxyphenyl)porphyrin (1) causes a delayed after-pulse growth in the conductivity over many µs. The slow diffusion of (1) triplet excitons was followed by electron injection into the TiO 2conduction band. Monte Carlo calculations of the exciton diffusion and exciton-exciton annihilation describe the experimentally observed temporal form and intensity dependence. Amphiphilic Polypyridyl Ruthenium Complexes with Substituted 2,2 ' -Dipyridylamine Ligands for Nanocrystalline Dye-Sensitized Solar Cells P. WANG, R. HUMPHRY-BAKER, J. E. MOSER, S. M. ZAKEERUDDINand M. GRÄTZEL, Chem. Mater., 2004,16, (17), 3246-3251 LINKdoi:10.1021/cm049871ohttp://dx.doi.org/10.1021/cm049871o Ru(dcbpy)(L)(NCS) 2dye (dcbpy = 4,4 '-dicarboxylic acid-2,2 '-bipyridine; L = N, N-di(2-pyridyl)-dodecylamine or N, N-di(2-pyridyl)-tetradecylamine) can be used as solar cell sensitisers. Efficiencies of 8.2% at the 100 mW cm -2irradiance of air mass 1.5 solar light and ≥ 8.7% at lower light intensities were achieved. APPARATUS AND TECHNIQUE Ethanol Gas Sensing Properties of Nano-Crystalline Cadmium Stannate Thick Films Doped with Pt Y.-L. LIU, Y. XING, H.-F. YANG, Z.-M. LIU, Y. YANG, G.-L. SHENand R.-Q. YU, Anal. Chim. Acta, 2004,527, (1), 21-26 LINK:doi:10.1016/j.aca.2004.06.055http://dx.doi.org/10.1016/j.aca.2004.06.055 Pt (0.1-2 at.%) was incorporated into nanocrystalline CdSnO 3(1) by the impregnation technique. Conductance responses of thick films of (1) were measured after exposure to EtOH, CO, CH 4, C 4H 10, gasoline and LPG at different operating temperatures. Sensors doped with Pt had good sensitivity and selectivity to EtOH vapour. The optimum sensitivity was obtained when (1) was doped with 1.5 at.% Pt. All-Optical Hydrogen-Sensing Materials Based on Tailored Palladium Alloy Thin Films Z. ZHAO, Y. SEVRYUGINA, M. A. CARPENTER, D. WELCHand H. XIA, Anal. Chem., 2004,76, (21), 6321-6326 LINKdoi:10.1021/ac0494883http://dx.doi.org/10.1021/ac0494883 The phase-dependent H time response characteristics of 20 nm thick Pd-Au (Ag) films (1) were investigated via optical reflectance measurements. They displayed a strong dependence on the α, mixed α/β and β Pd-hydride phases formed in (1). The response time peaks in the α → β phase transition region were 1625 s at 0.4% H 2for Pd 0.94Ag 0.06and 405 s at 1% H 2for Pd 0.94Au 0.06. The addition of Au (up to 40%) shifted and then inhibited the α → β phase transition region. Pd 0.6Au 0.4was above the critical isotherm threshold for undergoing a phase transition and had response time < 50 s. HETEROGENEOUS CATALYSIS Parallel IR Spectroscopic Characterization of CO Chemisorption on Pt Loaded Zeolites P. KUBANEK, H.-W. SCHMIDT, B. SPLIETHOFFand F. SCHÜTH, Microporous Mesoporous Mater., 2005,77, (1), 89-96 LINKdoi:10.1016/j.micromeso.2004.08.016http://dx.doi.org/10.1016/j.micromeso.2004.08.016 Parallel characterisation of Pt-containing zeolites ZSM-5 and Y was achieved using FTIR spectroscopy in transmission mode combined with a focal plane array detector. The Pt species in the zeolite were investigated using the chemisorption of CO. The 8-fold degree of parallelisation lowered the total time required for data collection. Conversion of Halon 1211 (CBrClF 2 ) over Supported Pd Catalysts H. YU, E. M. KENNEDY, MD. A. UDDIN, A. A. ADESINAand B. Z. DLUGOGORSKI, Catal. Today, 2004,97, (2-3), 205-215 LINKdoi:10.1016/j.cattod.2004.03.069http://dx.doi.org/10.1016/j.cattod.2004.03.069 The conversion of halon 1211 was investigated over γ-Al 2O 3and 0.5% Pd supported on Al 2O 3, fluorinated Al 2O 3, AlF 3, and Al 2O 3pretreated with CH 4and CHClF 2, at 443-523 K. The Pd was transformed to Pd carbide in the CH 4treated Pd/Al 2O 3, but not in the CHClF 2treated Pd/Al 2O 3(Al 2O 3was partially fluorinated). In the absence of H 2, the conversion of halon 1211 over Al 2O 3and Pd/Al 2O 3gave a similar product profile and the reactions follow a heterogeneous halogen exchange reaction pathway. Heck Reaction Catalyzed by Nanosized Palladium on Chitosan in Ionic Liquids V. CALÒ, A. NACCI, A. MONOPOLI, A. FORNARO, L. SABBATINI, N. CIOFFIand N. DITARANTO, Organometallics, 2004,23, (22), 5154-5158 LINKdoi:10.1021/om049586ehttp://dx.doi.org/10.1021/om049586e Pd nanoparticles/chitosan (1) was very effective for the Heck reaction of aryl bromides and activated aryl chlorides in tetrabutylammonium bromide with tetrabutylammonium acetate as base. Conversion of bromobenzene or p-nitrochlorobenzene into cinnamates took only 15 min. The Pd colloids are stabilised by the solvent. Any PdH is readily neutralised by the base. (1) can be recycled. One-Pot Synthesis of Recyclable Palladium Catalysts for Hydrogenations and Carbon-Carbon Coupling Reactions N. KIM, M. S. KWON, C. M. PARKand J. PARK, Tetrahedron Lett., 2004,45, (38), 7057-7059 LINKdoi:10.1016/j.tetlet.2004.07.126http://dx.doi.org/10.1016/j.tetlet.2004.07.126 Pd nanoparticles (1) were prepared from Pd(PPh 3) 4in tetra(ethylene glycol) and Si(OMe) 4(or Ti(O iPr) 4). (1) were then encapsulated in SiO 2(or TiO 2) matrix by treatment with H 2O. SiO 2(or TiO 2)/TEG/Pd showed high catalytic activity in alkene and alkyne hydrogenations and in Suzuki-Miyaura, Sonogashira, Heck-Mizoroki and Stille reactions. Surface Study of Rhodium Nanoparticles Supported on Alumina A. MAROTO-VALIENTE, I. RODRÍGUEZ-RAMOSand A. GUERRERO-RUIZ, Catal. Today, 2004,93-95, 567-574 LINKdoi:10.1016/j.cattod.2004.06.005http://dx.doi.org/10.1016/j.cattod.2004.06.005 Rh nanoparticles (1 and 3 wt.%)/Al 2O 3were studied by H 2and CO adsorption microcalorimetry and by IR spectroscopy of the chemisorbed CO. The n-butane hydrogenolysis reaction test was employed to examine surface sites. The energetic distribution of surface sites depended slightly on the metal loading and can be modified by the pretreatment conditions. Partially reduced Rh atoms stabilised by Cl ions remaining from the precursor were found. The increased density on Rh (1 1 1) planes on 3 wt.% Rh/Al 2O 3treated with H 2O enhanced both activity for the hydrogenolysis and selectivity towards ethane. HOMOGENEOUS CATALYSIS Palladium-Catalyzed Addition of Mono- and Dicarbonyl Compounds to Conjugated Dienes A. LEITNER, J. LARSEN, C. STEFFENSand J. F. HARTWIG, J. Org. Chem., 2004,69, (22), 7552-7557 LINKdoi:10.1021/jo0490999http://dx.doi.org/10.1021/jo0490999 An intermolecular addition of the α-C-H bond of monocarbonyl and 1,3-dicarbonyl compounds to dienes was achieved in high yields using a catalyst generated in situfrom CpPd(allyl) (1) and 1,3-bis(dicyclohexylphosphino)propane. The common additions of cyanoesters, malonitrile and α-sulfonyl esters readily took place; unusual additions of ketones, lactones, esters and nitriles were also possible. The first enantioselective version of this reaction was achieved using (1) and a Josiphos ligand with ≤ 81% ee. General and Efficient Methodology for the Suzuki-Miyaura Reaction in Technical Grade 2-Propanol O. NAVARRO, Y. OONISHI, R. A. KELLY, E. D. STEVENS, O. BRIELand S. P. NOLAN, J. Organomet. Chem., 2004,689, (23), 3722-3727 LINKdoi:10.1016/j.jorganchem.2004.04.001http://dx.doi.org/10.1016/j.jorganchem.2004.04.001 Pd N-heterocyclic carbenes or phosphines were investigated in the Suzuki-Miyaura reaction using technical grade 2-propanol (1) as solvent and K t-butoxide as base. The cross-coupling of electron-rich aryl chlorides with sterically hindered aryl boronic acids gave di- and tri- ortho-substituted biaryls in short times. (1) did not require pre-drying or purification. Palladium-Catalyzed Intramolecular α-Arylation of Aliphatic Ketone, Formyl, and Nitro Groups H. MURATAKE, M. NATSUMEand H. NAKAI, Tetrahedron, 2004,60, (51), 11783-11803 LINKdoi:10.1016/j.tet.2004.09.112http://dx.doi.org/10.1016/j.tet.2004.09.112 PdCl 2(Ph 3P) 2-Cs 2CO 3was used for the intramolecular arylation of substrates bearing a ketone, formyl or nitro terminating group to give carbocyclics. Arylation of the ketones gave benzene-annulated bridged or spirocycloalkanone derivatives, depending on the type of cyclisation precursors. Arylation in formyl compounds occurred in the α-position or at the carbonyl C depending on the type of cyclisation precursors and on the solvent. An α-arylated secondary nitro group was partially transformed to ketone, whereas a tertiary nitro group was partially eliminated to afford a styrene-type olefin. Successful Development and Scale-up of a Palladium-Catalysed Amination Process in the Manufacture of ZM549865 G. E. ROBINSON, O. R. CUNNINGHAM, M. DEKHANE, J. C. McMANUS, A. O'KEARNEY-McMULLAN, A. M. MIRAJKAR, V. MISHRA, A. K. NORTON, B. VENUGOPALANand E. G. WILLIAMS, Org. Process Res. Dev., 2004,8, (6), 925-930 LINKdoi:10.1021/op0499369http://dx.doi.org/10.1021/op0499369 Pd-catalysed amination and ester hydrolysis has been used to synthesise a key intermediate in the manufacture of ZM549865 (a 5-HT receptor antagonist). Pd dibenzylideneacetone was employed for the amination of ethyl 8-bromo-6-fluoro-4-oxo-4 H-2-chromenecarboxylate. Amination at 125ºC instead of 80ºC and optimising the reaction conditions increased the overall yield from 44% to ~ 70% and reduced the reaction time from days to hours. A Convenient Synthesis of High-Loaded Palladium(II) ROMP Polymers D. C. BRADDOCK, D. CHADWICKand E. LINDNER-LÓPEZ, Tetrahedron Lett., 2004,45, (49), 9021-9024 LINKdoi:10.1016/j.tetlet.2004.10.056http://dx.doi.org/10.1016/j.tetlet.2004.10.056 A method for the immobilisation of two O, O'-chelate Pd(II) complexes via ROMP has been established. The monomer bis[1-(5-norbornen-2-yl)butan-1,3-dionato]palladium(II) (1) was readily prepared from 5-acetoacetyl-2-norbornene and Na 2PdCl 4. (1) underwent ROMP under mild conditions to give a highly-loaded Pd(II)-containing polymer (Pd, 23 wt.%). Rhodium(II)-Catalyzed Aziridination of Allyl-Substituted Sulfonamides and Carbamates A. PADWA, A. C. FLICK, C. A. LEVERETTand T. STENGEL, J. Org. Chem., 2004,69, (19), 6377-6386 LINKdoi:10.1021/jo048990khttp://dx.doi.org/10.1021/jo048990k Unsaturated sulfonamides underwent intramolecular aziridination in the presence of PhI(OAc) 2, MgO and Rh 2(OAc) 4to give bicyclic aziridines in excellent yield. The resulting azabicyclic sulfonamides with the addition of p-TsOH in MeOH underwent exclusive opening of the aziridine ring at the most substituted position giving six- and seven-membered ring products in high yield. Iridium-Catalyzed Hydroboration of Alkenes with Pinacolborane Y. YAMAMOTO, R. FUJIKAWA, T. UMEMOTOand N. MIYAURA, Tetrahedron, 2004,60, (47), 10695-10700 LINKdoi:10.1016/j.tet.2004.09.014http://dx.doi.org/10.1016/j.tet.2004.09.014 Ir(I) phosphine complexes (1) are excellent catalysts for room temperature hydroboration of terminal and internal alkenes possessing an aliphatic or aromatic substituent on the vinylic C with pinacolborane. [Ir(cod)Cl] 2/2dppm was the best catalyst system for hydroboration of aliphatic terminal and internal alkenes at room temperature; addition of the B atom to the terminal C of 1-alkenes was achieved with > 99% selectivity. For vinylarenes such as styrene, [Ir(cod)Cl] 2/2dppe gave the best yields. (1) exhibited higher levels of catalyst activity and selectivity than the corresponding Rh complexes. FUEL CELLS Preparation and Characterization of Carbon Supported Pt and PtRu Alloy Catalysts Reduced by Alcohol for Polymer Electrolyte Fuel Cell T. KIM, M. TAKAHASHI, M. NAGAIand K. KOBAYASHI, Electrochim. Acta, 2004,50, (2-3), 813-817 LINKdoi:10.1016/j.electacta.2004.01.124http://dx.doi.org/10.1016/j.electacta.2004.01.124 Highly dispersed fine Pt and PtRu alloy particles on C support were prepared by a simple alcohol-reduction method using polyvinylpyrrolidone as a stabiliser. Highly uniform nanoparticles were obtained. The structure and morphology of the catalysts could be readily controlled. The catalysts showed promising activity in O reduction and MeOH oxidation. Methanol Electro-Oxidation and Direct Methanol Fuel Cell Using Pt/Rh and Pt/Ru/Rh Alloy Catalysts J.-H. CHOI, K.-W. PARK, I.-S. PARK, W.-H. NAMand Y.-E. SUNG, Electrochim. Acta, 2004,50, (2-3), 783-786 LINKdoi:10.1016/j.electacta.2004.01.109http://dx.doi.org/10.1016/j.electacta.2004.01.109 The title catalysts (1) for application in DMFCs were prepared by a borohydride reduction method combined with freeze drying. (1) had specific surface areas of ~ 65-75 m 2g -1. XRD patterns established that (1) were well alloyed and the average size of (1) was confirmed by TEM. (1) of composition Pt/Rh (2:1) and Pt/Ru/Rh (5:4:1) had better catalytic activities for MeOH electrooxidation than Pt or Pt/Ru (1:1), respectively. Performance of Methanol Oxidation Catalysts with Varying Pt:Ru Ratio as a Function of Temperature A. J. DICKINSON, L. P. L. CARRETTE, J. A. COLLINS, K. A. FRIEDRICHand U. STIMMING, J. Appl. Electrochem., 2004,34, (10), 975-980 LINK doi:10.1023/B:JACH.0000042668.61391.a4http://dx.doi.org/10.1023/B:JACH.0000042668.61391.a4 At 25ºC, a Pt-rich 3:2 Pt:Ru atomic ratio DMFC-type catalyst was more active for MeOH oxidation than a 1:1 catalyst. Only the Pt is active towards MeOH dehydrogenation, as this process requires high thermal activation on Ru sites. At 65ºC, the 1:1 catalyst gave much higher currents across the entire polarisation range. At 45ºC, the 3:2 catalyst is better at lower current values, while the 1:1 catalyst is superior at higher current densities. MEDICAL USES Synthesis and DNA-Binding Properties of Binuclear Platinum Complexes with Two trans -[Pt(NH 3 ) 2 Cl] + Units Bridged by 4,4 ' -Dipyridyl Sulfide or Selenide G. ZHAO, X. HU, P. YUand H. LIN, Transition Met. Chem., 2004, 29, (6), 607-612 LINKdoi:10.1007/s11243-004-1278-1http://dx.doi.org/10.1007/s11243-004-1278-1 { trans-[Pt(NH 3) 2Cl] 2(dpsu)}(NO 3) 2(1) and { trans-[Pt(NH 3) 2Cl] 2(dpse)}(NO 3) 2(dpsu = 4,4 '-dipyridyl sulfide; dpse = 4,4 '-dipyridyl selenide) were prepared for use as potential antitumour agents. Compared with [ cis-Pt(NH 3) 2Cl(4-methylpyridine)]NO 3, (1) exhibits an almost two-fold stronger DNA-binding ability. (1) may bind bifunctionally to DNA. Synthesis, Characterization, and Cytotoxicities of Palladium(II) and Platinum(II) Complexes Containing Fluorinated Pyridinecarboxaldimines S. J. SCALES, H. ZHANG, P. A. CHAPMAN, C. P. McRORY, E. J. DERRAH, C. M. VOGELS, M. T. SALEH, A. DECKENand S. A. WESTCOTT, Polyhedron, 2004,23, (13), 2169-2176 LINKdoi:10.1016/j.poly.2004.06.013http://dx.doi.org/10.1016/j.poly.2004.06.013 The condensation of 2-pyridinecarboxaldehyde with primary amines containing F groups gave the corresponding pyridinecarboxaldimine ligands (N-N '). Addition of these ligands to [MCl 2(coe)] 2(M = Pt, Pd; coe = cis-cyclooctene) gave cis-MCl 2(N-N ') (1) in moderate to high yields. Cytotoxicities of (1) were investigated against OV2008 (human ovarian carcinoma) and the analogous cisplatin-resistant C13. The Potential Use of Rhodium N-Heterocyclic Carbene Complexes as Radiopharmaceuticals: The Transfer of a Carbene from Ag(I) to RhCl 3 ·3H 2 O C. A. QUEZADA, J. C. GARRISON, M. J. PANZNER, C. A. TESSIERand W. J. YOUNGS, Organometallics, 2004,23, (21), 4846-4848 LINKdoi:10.1021/om049697dhttp://dx.doi.org/10.1021/om049697d The first reported N-heterocyclic carbene transfer from Ag(I) to RhCl 3·3H 2O was used to prepare two new Rh N-heterocyclic carbenes (1). The syntheses were carried out in DMSO at 100ºC for 1 h. The very high stability of (1) indicates that 105Rh complexes of bisimidazole ligands with targeting substituents such as peptides may be used for radiation therapy. Find an article ArticleSearch
https://technology.matthey.com/article/49/1/54-57/10.1039/10.1039/10.1016/10.1007/10.1021/cm049265t
ABSTRACTS: April 2005 - technology.matthey.com ABSTRACTS: April 2005 Journal Archive Platinum Metals Rev., 2005, 49 , (2), 102 doi: 10.1595/147106705X46496 ABSTRACTS: April 2005 of current literature on the platinum metals and their alloys CHEMICAL COMPOUNDS Dimeric Palladium Complexes with Bridging Aryl Groups: When Are They Stable? A. C. ALBÉNIZ, P. ESPINET, O. LÓPEZ-CIMAS and B. MARTÍN-RUIZ, Chem. Eur. J., 2005,11, (1), 242–252 LINKdoi:10.1002/chem.200400612http://dx.doi.org/10.1002/chem.200400612 [Pd 2(μ-R) 2(η 3-allyl) 2] (R = haloaryl, mesityl) were prepared. The haloaryl complexes exchange between their cisand transisomers (relative to the orientation of the two allyl groups in the dimer) by solvent-assisted associative bridge splitting. Stable aryl bridges are favoured by ancillary ligands of small size and lacking electron lone pairs, and aryl ligands reluctant to be involved in homo and hetero C–C coupling. Synthesis, Structure and Electrochemical Properties of Tris-picolinate Complexes of Rhodium and Iridium S. BASU, S.-M. PENG, G.-H. LEE and S. BHATTACHARYA, Polyhedron, 2005,24, (1), 157–163 LINKdoi:10.1016/j.poly.2004.10.015http://dx.doi.org/10.1016/j.poly.2004.10.015 The pic ligands of [M(pic) 3] (1) (M = Rh, Ir; Hpic = picolinic acid) are coordinated as bidentate N,O-donors. A water of crystallisation molecule is H bonded to the carboxylate fragments of two adjacent (1) and acts a bridge between the individual (1). (1) are diamagnetic and show intense MLCT transitions in the visible region. CV on (1) shows a M(III)–M(IV) oxidation and a ligand-centred reductive response. Iridium(I) and Rhodium(I) Cationic Complexes with Triphosphinocalix[6]arene Ligands: Dynamic Motion with Size-Selective Molecular Encapsulation Y. OBORA, Y. K. LIU, L. H. JIANG, K. TAKENAKA, M. TOKUNAGA and Y. TSUJI, Organometallics, 2005,24, (1), 4–6 LINKdoi:10.1021/om049227jhttp://dx.doi.org/10.1021/om049227j The title complexes (1) exhibited dynamic behaviour with size-selective molecular encapsulation. Variable-temperature 31P{ 1H} NMR measurements were carried out in the presence of various molecules (1). (1) were divided into three groups, depending on the maximum projection area of the solvent-accessible surface, A: < 45 Å 2, 45–68 Å 2, and > 68 Å 2. Molecules with Aof 45–68 Å 2just fit in the cavity and slow the dynamic behaviour. Synthesis and Derivatization of Iridium(I) and Iridium(III) Pentamethyl[60]fullerene Complexes Y. MATSUO, A. IWASHITA and E. NAKAMURA, Organometallics, 2005,24, (1), 89–95 LINKdoi:10.1021/om049333lhttp://dx.doi.org/10.1021/om049333l Ir(η 5-C 60Me 5)(CO) 2(1) was obtained from the reaction of K(C 60Me 5) with [IrCl(CO) 2] 2in MeCN/THF. Oxidation of the Ir atom of (1) by I 2gave an Ir(III) complex, Ir(η 5-C 60Me 5)I 2(CO) (2). The iodo and carbonyl ligands of (2) can be readily replaced by alkyl, alkynyl, phosphine, and isonitrile ligands. (2) may be used as catalysts for organic synthesis. ELECTROCHEMISTRY Electrochemical Investigations of Platinum Phenylethynyl Complexes L. KONDRACHOVA, K. E. PARIS, P. C. SANCHEZ, A. M. VEGA, R. PYATI and C. D. RITHNER, J. Electroanal. Chem., 2005,576, (2), 287–294 LINKdoi:10.1016/j.jelechem.2004.11.003http://dx.doi.org/10.1016/j.jelechem.2004.11.003 Pt phenylethynyl complexes exhibited irreversible oxidations in benzene/MeCN near +1.2 V vs. Ag|AgCl. However, trans-bis(tri- n-butylphosphine) bis(phenylethynyl)platinum(II) underwent reduction in THF at –2.786 V. Photophysical measurements established that as the phenylethynyl chain length increases, the absorbance wavelength increases. The emission wavelength shows a weak but similar trend. Controlled Growth of a Single Palladium Nanowire between Microfabricated Electrodes M. A. BANGAR, K. RAMANATHAN, M. YUN, C. LEE, C. HANGARTER and N. V. MYUNG, Chem. Mater., 2004,16, (24), 4955–4959 LINKdoi:10.1021/cm048931nhttp://dx.doi.org/10.1021/cm048931n Dimensionally controlled growth of a single Pd nanowire (1) between premicrofabricated Au electrodes was achieved using an electrochemical method. (1) of 100 nm, 500 nm, and 1 μm wide and 2.5 μm long channels (length-to-diameter ratio ~ 2.5–25) were grown. Current of –100 nA was used. PHOTOCONVERSION A Luminescent Pt(II) Complex with a Terpyridine-Like Ligand Involving a Six-Membered Chelate Ring Y.-Z. HU, M. H. WILSON, R. ZONG, C. BONNEFOUS, D. R. McMILLIN and R. P. THUMMEL, Dalton Trans., 2005, (2), 354–358 LINKdoi:10.1039/b415021jhttp://dx.doi.org/10.1039/b415021j [Pt(1)Cl] +(2) ((1) = 2-(8 '-quinolinyl)-1,10-phenanthroline) was prepared. The six-membered chelate ring in (2) gives relief to the angle strain as well as some non-planarity in bound (1). In CH 2Cl 2(2) exhibited higher energy charge-transfer absorption, but slightly lower energy emission than [Pt(3)Cl] +((3) = 2-(2 '-pyridyl)-1,10-phenanthroline). Electrochemical and Luminescent Properties of New Mononuclear Ruthenium(II) and Binuclear Iridium(III)-Ruthenium(II) Terpyridine Complexes N. YOSHIKAWA, T. MATSUMURA-INOUE, N. KANEHISA, Y. KAI, H. TAKASHIMA and K. TSUKAHARA, Anal. Sci., 2004,20, (12), 1639–1644 LINKdoi:10.2116/analsci.20.1639http://dx.doi.org/10.2116/analsci.20.1639 The title complexes include [Ru II 2Cl 2(dpp)(terpy) 2] 2+(1) and [Ir IIIRu IICl 2(dpp)(terpy) 2] 3+(2) (dpp = 2,3-bis(2-pyridyl)pyrazine). The absorption spectra of (1) and (2) exhibit ligand-centred bands in the UV region and MLCT bands in the visible region. The HOMO is based on Ru, and the LUMO is dpp-based. Design of Novel Efficient Sensitizing Dye for Nanocrystalline TiO 2 Solar Cell; Tripyridine-thiolato (4,4 ' ,4 '' -tricarboxy-2,2 ' :6 ' ,2 '' -terpyridine) ruthenium(II) F. AIGA and T. TADA, Sol. Energy Mater. Sol. Cells, 2005,85, (3), 437–446 LINKdoi:10.1016/j.solmat.2004.04.020http://dx.doi.org/10.1016/j.solmat.2004.04.020 The title Ru complex (1) was designed based on the DFT MO calculations with PBE0 functional. (1) is a modification of the Ru black dye (2), with the NCS ligands of (2) being replaced by C 5H 4NS ligands. (1) has a higher electron transfer rate from redox systems to oxidised dyes and higher absorption efficiency to the solar spectrum. A Highly Efficient Redox Chromophore for Simultaneous Application in a Photoelectrochemical Dye Sensitized Solar Cell and Electrochromic Devices A. F. NOGUEIRA, S. H. TOMA, M. VIDOTTI, A. L. B. FORMIGA, S. I. CÓRDOBA DE TORRESI and H. E. TOMA, New J. Chem., 2005,29, (2), 320–324 LINKdoi:10.1039/b411122bhttp://dx.doi.org/10.1039/b411122b Na 6[{Ru II(dicarboxybipyridine) 2Cl} 2(BPEB)] (1) (BPEB = trans-1,4-bis[2-(4-pyridyl)ethenyl]benzene) exhibits an electrochromic effect when reduced. The carboxylate groups of the bipyridine allow strong attachment to the surface of TiO 2. This contributes to an efficient and reversible electron transfer from the oxide to the chromophoric ligand, colouring the oxide film blue. (1) also has a high photon-to-electron conversion efficiency when applied as a photoanode in a dye sensitised solar cell. ELECTRODEPOSITION AND SURFACE COATINGS Characterizations of Pd–Ag Membrane Prepared by Sequential Electroless Deposition W.-H. LIN and H.-F. CHANG, Surf. Coat. Technol., 2005,194, (1), 157–166 LINKdoi:10.1016/j.surfcoat.2004.07.089http://dx.doi.org/10.1016/j.surfcoat.2004.07.089 Sequential electroless plating on porous stainless steel was used to prepare Pd-Ag membranes. AFM established that lower skin layer roughness and lower deposition rate were related. EDS confirmed the Pd-Ag deposit over and inside of the porous substrate to be homogeneous. Preparation of Palladium and Silver Alloy Membrane on a Porous α-Alumina Tube via a Simultaneous Electroless Plating D. A. PACHECO TANAKA, M. A. LLOSA TANCO, S. NIWA, Y. WAKUI, F. MIZUKAMI, T. NAMBA and T. M. SUZUKI, J. Membrane Sci., 2005,247, (1–2), 21–27 LINKdoi:10.1016/j.memsci.2004.06.002http://dx.doi.org/10.1016/j.memsci.2004.06.002 For the title process, seeding of Pd nanoparticles (1) on an α-Al 2O 3tube allowed codeposition of Pd and Ag. (1) were distributed by dip-coating with Pd acetate or [Pd(acac) 2] in organic solvents followed by reduction with alkaline hydrazine solution. After simultaneous deposition, alloying of Pd and Ag was carried out at 500ºC for 4 h in H 2. Morphological Evolution of the Self-Assembled IrO 2 One-Dimensional Nanocrystals R.-S. CHEN, H.-M. CHANG, Y.-S. HUANG, D.-S. TSAI and K.-C. CHIU, Nanotechnology, 2005,16, (1), 93–97 LINKdoi:10.1088/0957-4484/16/1/019http://dx.doi.org/10.1088/0957-4484/16/1/019 The morphological evolution of IrO 21D nanocrystals (1) via MOCVD has been observed. (1) result from a decrease in the degree of interface instability. (1) occur from triangular/wedged nanorods via incomplete/scrolled nanotubes to square nanotubes and square nanorods. The polycrystalline films composed of continuous 3D grains belong to the most stable form as compared to the 1D nanocrystals. Thermophysical Properties and Deposition of B2 Structure Based Al–Ni–Ru–M Alloys I. VJUNITSKY, P. P. BANDYOPADHYAY, St. SIEGMANN, M. DVORAK, E. SCHÖNFELD, T. KAISER, W. STEURER and V. SHKLOVER, Surf. Coat. Technol., 2005,192, (2–3), 131–138 LINKdoi:10.1016/j.surfcoat.2004.09.028http://dx.doi.org/10.1016/j.surfcoat.2004.09.028 The normal value range for the thermal conductivity of the title alloys is 10–20 W m –1K –1at room temperature, but can be reduced to ~ 3.5 W m –1K –1by modifying the alloy composition. A fused and subsequently pulverised Al-Ni-Ru alloy was deposited on a Ni-based superalloy (modified CMSX-4) using vacuum and atmospheric plasma spraying. The coatings had favourable coating–substrate adhesion. A segregated intermetallic phase was detected at the Al 50Ni 40Ru 10/modified CMSX-4 interface. APPARATUS AND TECHNIQUE Fabrication and Characterisation of Ultra-Thin Tungsten–Carbon (W/C) and Platinum–Carbon (Pt/C) Multilayers for X-Ray Mirrors B. K. GAN, B. A. LATELLA and R. W. CHEARY, Appl. Surf. Sci., 2005,239, (2), 237–245 LINKdoi:10.1016/j.apsusc.2004.05.269http://dx.doi.org/10.1016/j.apsusc.2004.05.269 Ultra-thin Pt/C and W/C multilayer films (1) were fabricated using DC magnetron sputtering. The bilayer period and the total number of layers were varied to ascertain the X-ray reflectance response. XPS established that a distinct intermixing layer develops in (1). (1) are mechanically reliable and have excellent adhesion. Hardness and Young's modulus improved with increasing number of layers. (1) have potential as mirrors for high energy X-ray applications. Morphological Study of Supported Thin Pd and Pd–25Ag Membranes upon Hydrogen Permeation Y. ZHANG, M. KOMAKI and C. NISHIMURA, J. Membrane Sci., 2005,246, (2), 173–180 LINKdoi:10.1016/j.memsci.2004.09.002http://dx.doi.org/10.1016/j.memsci.2004.09.002 H 2permeation of Pd and Pd-25Ag membranes supported by V-15Ni was investigated at 423–673 K. The Pd-25Ag membrane was more resistant to H-induced cracking and grain growth. H permeation of the Pd-25Ag/V-15Ni membrane (1) was carried out at 573 and 673 K for 200 h. At 573 K, small amounts of oxide formed on the Pd-Ag surface. Whisker and fissure-oxide morphologies were dominant on the exit and entrance side of (1), respectively, along with severe metallic interdiffusion, at 673 K. HETEROGENEOUS CATALYSIS Preparation and Characterisation of Pt Containing NbMCM-41 Mesoporous Molecular Sieves Addressed to Catalytic NO Reduction by Hydrocarbons I. SOBCZAK, M. ZIOLEK and M. NOWACKA, Microporous Mesoporous Mater., 2005,78, (2–3), 103–116 LINKdoi:10.1016/j.micromeso.2004.10.001http://dx.doi.org/10.1016/j.micromeso.2004.10.001 The title catalysts were prepared via impregnation of NbMCM-41 with Pt(NH 3) 4(NO 3) 2or H 2PtCl 6(1 wt.% of Pt). Smaller size Pt clusters were obtained with H 2PtCl 6. A FTIR study with NO + O 2+ C 3H 6indicated that Pt/NbMCM-41 has potential for the SCR process. The NbO –species enhance the oxidative activity in NO → NO 2, whereas the Pt species is responsible for hydrocarbon activation. NbMCM-41 acts as storage for the nitrate/nitrite species. Flame-Made Pd/La 2 O 3 /Al 2 O 3 Nanoparticles: Thermal Stability and Catalytic Behavior in Methane Combustion R. STROBEL, S. E. PRATSINIS and A. BAIKER, J. Mater. Chem., 2005,15, (5), 605–610 LINKdoi:10.1039/b413198chttp://dx.doi.org/10.1039/b413198c Flame spray pyrolysis was used to prepare Pd nanoparticles (< 5 nm) supported on La-stabilised Al 2O 3(1) with specific surface areas of 50–180 m 2g –1. (1) was tested for the catalytic combustion of CH 4. (1) exhibited excellent thermal stability in terms of specific surface area up to 1200ºC and retarded γ- to α-Al 2O 3transformation. (1) was tested as-prepared and after sintering at 1000ºC (Pd particles, 50–150 nm). All the materials exhibited similar catalytic performance after an initial conditioning cycle if the temperature was cycled several times (200–1000ºC). Effect of the Promoter and Support on the Catalytic Activity of Pd–CeO 2 -Supported Catalysts for CH 4 Combustion G. PECCHI, P. REYES, R. ZAMORA, T. LÓPEZ and R. GÓMEZ, J. Chem. Technol. Biotechnol., 2005,80, (3), 268–272 LINK:doi:10.1002/jctb.1120http://dx.doi.org/10.1002/jctb.1120 Pd-CeO 2-supported catalysts, prepared by the sol-gel technique, were used for the catalytic combustion of CH 4. The addition of CeO 2to Al 2O 3gave a highly dispersed catalyst when compared with their ZrO 2counterparts. However, the catalytic activity of the Pd-CeO 2-ZrO 2series is higher, due to the Pd having a larger particle size. The Oxidation of Water by Cerium(IV) Catalysed by Nanoparticulate RuO 2 on Mesoporous Silica N. C. KING, C. DICKINSON, W. ZHOU and D. W. BRUCE, Dalton Trans., 2005, (6), 1027–1032 LINKdoi:10.1039/b415288chttp://dx.doi.org/10.1039/b415288c Mesoporous silicates were prepared by templating on the hexagonal mesophase of bis(2,2 '-bipyridine)(4,4 '-dinonadecyl-2,2 '-bipyridine)ruthenium(II) dichloride using liquid-crystal templating. On calcination, the surfactant template was removed, except for the central Ru ion that was oxidised to RuO 2nanoparticles (1) within the pores. (1) were active in catalysing the oxidation of H 2O by acidic Ce IV. HOMOGENEOUS CATALYSIS Pd Nanoparticle Aging and Its Implications in the Suzuki Cross-Coupling Reaction J. HU and Y. LIU, Langmuir, 2005,21, (6), 2121–2123 LINKdoi:10.1021/la0471902http://dx.doi.org/10.1021/la0471902 The Pd nanoparticles (1) recovered from the N, N-dihexylcarbodiimide–Pd nanoparticle composite catalysts used in Suzuki cross-couplings, were found to transform from spherical-shape to larger needle-shaped crystals. (1) aggregated into nanosized blackberry-like assemblies (100–200 nm) as a result of Ostwald ripening. In a second type of ripening, atomic rearrangement occurred and (1) transformed into needle-shaped nanocrystals. These observations will be important for the future design and optimisation of durable nanoparticle catalysts. Pd(II)-Biquinoline Catalyzed Aerobic Oxidation of Alcohols in Water B. P. BUFFIN, J. P. CLARKSON, N. L. BELITZ and A. KUNDU, J. Mol. Catal. A: Chem., 2005,225, (1), 111–116 LINKdoi:10.1016/j.molcata.2004.08.035http://dx.doi.org/10.1016/j.molcata.2004.08.035 Pd(OAc) 2stabilised by 2,2 '-biquinoline-4,4 '-dicarboxylic acid was used in the aerobic oxidation of primary and secondary alcohols. H 2O was used as the reaction solvent, with air as the oxidant. Aliphatic primary alcohols were fully oxidised to carboxylic acid products. Secondary alcohols gave the corresponding ketones. The catalyst can be recycled. New Carbazole–Oxadiazole Dyads for Electroluminescent Devices: Influence of Acceptor Substituents on Luminescent and Thermal Properties K. R. J. THOMAS, J. T. LIN, Y.-T. TAO and C.-H. CHUEN, Chem. Mater., 2004,16, (25), 5437–5444 LINKdoi:10.1021/cm048794uhttp://dx.doi.org/10.1021/cm048794u Oxadiazole-incorporated carbazoylylamines (1) were synthesised using Pd catalysed C–N coupling reactions with Pd(dba) 2/P( t-Bu) 3catalyst and t-BuONa base. The reactions were best carried out in toluene at 80ºC. Yields of (1) ranged from 75–95%. (1) were purified by reprecipitating twice from CH 2Cl 2/MeOH before application in the electroluminescent devices, such as OLEDs. Hydroformylation of 1-Hexene in Ionic Liquids Catalyzed by Highly Active Rhodium-Phosphine Complexes H. ZHENG, M. LI, H. CHEN, R. LI and X. LI, Chin. J. Catal., 2005,26, (1), 4–6 The hydroformylation of 1-hexene catalysed by HRh(CO)(TPPTS) 3complexes (1) (TPPTS = triphenylphosphine- m-trisulfonic acid trisodium salt) was carried out in 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF 4). The activity and selectivity of (1) in [bmim]BF 4were higher than those in other ionic liquids. The TOF of 1-hexene and selectivity for aldehyde were 1508 h –1and 92%, respectively, under optimum conditions. The high activity of (1) is due to its higher solubility in [bmim]BF 4and to the absence of halide ions. Mononuclear Ruthenium Catalysts for the Direct Propargylation of Heterocycles with Propargyl Alcohols E. BUSTELO and P. H. DIXNEUF, Adv. Synth. Catal., 2005,347, (2–3), 393–397 LINKdoi:10.1002/adsc.200404219http://dx.doi.org/10.1002/adsc.200404219 While [( p-cymene)RuCl(PR 3)][OTf] (PR 3) (PR 3= PCy 3, PPh 3) catalyse the propargylation of furan or 2-methylfuran by the alkynol HCºCCH(OH)Ph in moderate yield, [( p-cymene)RuCl(CO)(PR 3)][OTf] are more active. The stoichiometric reaction of [( p-cymene)RuCl(PR 3)][B(Ar F) 4] (Ar F= 3,5-(CF 3) 2C 6H 3) and the alkynol resulted in the in situformation, viaallenylidene and hydroxycarbene intermediates, of [( p-cymene)RuCl(CO)(PR 3)]B(Ar F) 4]. An Efficient Catalytic Asymmetric Route to 1-Aryl-2-imidazol-1-yl-ethanols I. C. LENNON and J. A. RAMSDEN, Org. Process Res. Dev., 2005,9, (1), 110–112 LINKdoi:10.1021/op049838nhttp://dx.doi.org/10.1021/op049838n Catalytic asymmetric transfer hydrogenation of 1-aryl-2-imidazol-1-yl-ethanones with formic acid using [( R, R)-TsDPEN]Ru(Cymene)Cl gave homochiral 1-aryl-2-imidazol-1-yl-ethanols. The hydrogenation was carried out under mild conditions at a molar substrate-to-catalyst ratio of 1000–2000. Bisphosphino Ru diamine complexes were found to be ineffective. FUEL CELLS High-Temperature Polymer Electrolytes for PEM Fuel Cells: Study of the Oxygen Reduction Reaction (ORR) at a Pt–Polymer Electrolyte Interface Z. LIU, J. S. WAINRIGHT and R. F. SAVINELL, Chem. Eng. Sci., 2004,59, (22–23), 4833–4838 LINKdoi:10.1016/j.ces.2004.09.024http://dx.doi.org/10.1016/j.ces.2004.09.024 A micro-band electrode cell was used to investigate the ORR for a Pt/polybenzimidazole–phosphoric acid system. The obtained Tafel plots were linear over four orders of magnitudes of kinetic current density. Both the kinetic parameters and the mass transport data were comparable to those of a Pt/phosphoric acid system. Effects of Preparation Conditions on Performance of Carbon-Supported Nanosize Pt-Co Catalysts for Methanol Electro-Oxidation under Acidic Conditions J. ZENG and J. Y. LEE, J. Power Sources, 2005,140, (2), 268–273 LINKdoi:10.1016/j.jpowsour.2004.08.022http://dx.doi.org/10.1016/j.jpowsour.2004.08.022 Pt/C and Pt-Co/C were prepared by NaBH 4reduction of metal precursors. Citric acid was used as the complexing agent. The largest Pt-Co particles (12 nm) were formed in alkaline solution and the smallest particles (3.7 nm) in unbuffered solution. XPS showed that Pt is in the metallic state, whereas most of the Co is oxidised. The performance of the Pt-Co/C catalysts in MeOH electrooxidation under acidic conditions showed improvements over the Pt/C catalyst in both activity and CO-tolerance due to the Co addition. Catalytic Activity of Pt–Ru Alloys Synthesized by a Microemulsion Method in Direct Methanol Fuel Cells L. XIONG and A. MANTHIRAM, Solid State Ionics, 2005, 176, (3–4), 385–392 LINKdoi:10.1016/j.ssi.2004.08.005http://dx.doi.org/10.1016/j.ssi.2004.08.005 A microemulsion method was used to prepare nanostructured Pt-Ru/C catalysts (1) with different particle sizes. The electrochemical performances of (1) were evaluated in half cells with a mixture of 1 M H 2SO 4and 1 M MeOH and in single cell DMFCs. (1) prepared with a water to surfactant molar ratio ( W) of 10 exhibited the maximum mass activity with the least charge transfer resistance at an optimum particle size of ~ 5.3 nm. The mass activity decreases and the charge transfer resistance increases as the value of Wdecreases or increases from 10. The Behavior of Palladium Catalysts in Direct Formic Acid Fuel Cells Y. ZHU, Z. KHAN and R. I. MASEL, J. Power Sources, 2005,139, (1–2), 15–20 LINKdoi:10.1016/j.jpowsour.2004.06.054http://dx.doi.org/10.1016/j.jpowsour.2004.06.054 Pd-based anode catalysts were used in DFAFCs. Power densities of 255 to 230 mW cm –2were achieved at relatively high voltages of 0.40 to 0.50 V in formic acid (3.0 to 15.0 M) at 20ºC. A MEA with a Pd catalyst gave some decay in fuel cell performance over several hours. However, the performance can be completely recovered by applying a positive potential at the anode. ELECTRICAL AND ELECTRONIC ENGINEERING On the Perpendicular Anisotropy of Co/Pd Multilayers J. I. HONG, S. SANKAR, A. E. BERKOWITZ and W. F. EGELHOFF, J. Magn. Magn. Mater., 2005,285, (3), 359–366 LINKdoi:10.1016/j.jmmm.2004.07.054http://dx.doi.org/10.1016/j.jmmm.2004.07.054 Co/Pd multilayers were deposited both at room temperature when thermally activated interfacial intermixing augmented the intentional alloying, and at 77 K. Stressed interfacial alloying is the dominant mechanism. Low temperature measurements indicated the presence of polarised Pd. The hard-axis magnetisation was modelled with a distribution of local perpendicular anisotropies which reflect local composition variations. Synthesis and Characterization of CaRuO 3 and SrRuO 3 for Resistor Paste Application K. GURUNATHAN, N. VYAWAHARE and D. P. AMALNERKAR, J. Mater. Sci.: Mater. Electron., 2005,16, (1), 47–53 LINKdoi:10.1007/s10854-005-4958-5http://dx.doi.org/10.1007/s10854-005-4958-5 Ca and Sr ruthenates (1) were prepared by air heating admixtures of the respective carbonates of Ca/Sr and RuO 2at 500, 800 and 900ºC for 15 h. The solid-state reactions occurred at 700–800ºC. These powders still contained carbonate and hence were heated again at 900ºC for 15 h to eliminate the carbonate. The average particle size of (1) is ~ 200–400 nm. The resistor paste was formulated using (1) prepared at 800 or 900ºC and heat treated at 900ºC. Find an article ArticleSearch
https://technology.matthey.com/article/49/2/102-105/10.1007/10.1007/10.1039/10.1016/10.1021/op049838n
Healthcare Fraud Analytics Market by Solution Type (Descriptive, Predictive, Prescriptive), Application (Insurance Claim, Payment Integrity), Delivery (On-premise, Cloud), End User (Government, Employers, Payers), COVID-19 Impac - Global Forecast to 2026 Healthcare Fraud Analytics Market by Solution Type (Descriptive, Predictive, Prescriptive), Application (Insurance Claim, Payment Integrity), Delivery (On-premise, Cloud), End User (Government, Employers, Payers), COVID-19 Impac - Market research report and industry analysis - 30218548 Healthcare Fraud Analytics Market by Solution Type (Descriptive, Predictive, Prescriptive), Application (Insurance Claim, Payment Integrity), Delivery (On-premise, Cloud), End User (Government, Employers, Payers), COVID-19 Impac - Global Forecast to 2026 Best Price Guarantee Price from $4,950 Length 173 Pages Publisher MarketsandMarkets Published Date October, 2021 SKU MKMK16805245 Table of Contents Description Healthcare Fraud Analytics Market by Solution Type (Descriptive, Predictive, Prescriptive), Application (Insurance Claim, Payment Integrity), Delivery (On-premise, Cloud), End User (Government, Employers, Payers), COVID-19 Impac - Global Forecast to 2026The global healthcare fraud analytics market is projected to reach USD 5.0 billion by 2026 from USD 1.5 billion in 2021, at a CAGR of 26.7% during the forecast period. Market growth can be attributed to a large number of fraudulent activities in healthcare, increasing number of patients seeking health insurance, high returns on investment, and the rising number of pharmacy claims-related frauds. However, the dearth of skilled personnel is expected to restrain the growth of this market.The on-demand segment is expected to grow at the highest CAGR during the forecast periodOn the basis of delivery model, the healthcare fraud analytics market is segmented into on-premise and on-demand models. The on-demand models include the cloud-based and web-based models. The on-demand segment is projected to register the highest CAGR during the forecast period. Factors such as on-demand self-serving analytics, the lack of up-front capital investments for hardware, extreme capacity flexibility, and a pay-as-you-go pricing model are driving the demand for on-demand fraud detection solutions.The prepayment review model segment is projected to witness the highest growth during the forecast periodOn the basis of application, the healthcare fraud analytics market is segmented into insurance claims review, pharmacy billing misuse, payment integrity, and other applications. The insurance claims review segment is further divided into postpayment and prepayment review, with the latter expected to register the highest growth during the forecast period. This is mainly because the use of prepayment review protocols and analytics can help organizations proactively prevent fraud prior to payment, allowing rapid action to be taken. As a result, prepayment review solutions are expected to garner greater attention in the coming years.North America accounted for the largest share of the healthcare fraud analytics marketThe healthcare fraud analytics market is segmented into five major regions, namely, North America, Europe, Asia, Pacific, Latin America, and the Middle East & Africa. North America accounted for the largest share of this market in 2020 majorly due to the high penetration of health insurance in the region, high number of healthcare fraud cases, favorable government initiatives to combat healthcare fraud, and wider product and service availability in this region. Moreover, a majority of leading players in the healthcare fraud analytics market have their headquarters in North AmericaBreak of primary participants was as mentioned below:By Company Type – Tier 1–45%, Tier 2–18%, and Tier 3–37%By Designation – C-level–35%, Director-level–50%, Others–15%By Region – North America–60%, Europe–22%, Asia–13%, Latin America- 3%, Middle East and Africa–2%Key players in the Healthcare Fraud Analytics marketMajor players in this market include IBM Corporation (US), Optum, Inc. (US), Cotiviti, Inc. (US), Change Healthcare (US), Fair Isaac Corporation (US), SAS Institute Inc. (US), EXLService Holdings, Inc. (US), Wipro Limited (India), Conduent, Incorporated (US), CGI Inc. (Canada), HCL Technologies Limited (India), Qlarant, Inc. (US), DXC Technology (US), Northrop Grumman Corporation (US), LexisNexis (US), Healthcare Fraud Shield (US), Sharecare, Inc. (US), FraudLens, Inc. (US), HMS Holding Corp. (US), Codoxo (US), H20.ai (US), Pondera Solutions, Inc. (US), FRISS (The Netherlands), Multiplan (US), FraudScope (US), and OSP Labs (US).Research Coverage:The report analyzes the healthcare fraud analytics market and aims at estimating the market size and future growth potential of this market based on various segments such as solution type, application, delivery model, end user, and region. The report also includes a product portfolio matrix of various healthcare fraud analytic solutions available in the market. The report also provides a competitive analysis of the key players in this market, along with their company profiles, product & service offerings, and key market strategies.Reasons to Buy the ReportThe report will enrich established firms as well as new entrants/smaller firms to gauge the pulse of the market, which in turn would help them, garner a more significant share of the market. Firms purchasing the report could use one or any combination of the below-mentioned strategies to strengthen their position in the market.This report provides insights into the following pointers:Market Penetration: Comprehensive information on product portfolios offered by the top players in the global healthcare fraud analytics market. The report analyzes this market by solution type, application, delivery model, and end userSolution Enhancement/Innovation: Detailed insights on upcoming trends and solution launches in the global healthcare fraud analytics marketMarket Development: Comprehensive information on the lucrative emerging markets by products and services, and end userMarket Diversification: Exhaustive information about new solutions or service enhancements, growing geographies, recent developments, and investments in the global healthcare fraud analytics marketCompetitive Assessment: In-depth assessment of market shares, growth strategies, solution offerings, competitive leadership mapping, and capabilities of leading players in the global healthcare fraud analytics market. INTRODUCTION OBJECTIVES OF THE STUDY MARKET DEFINITION & SCOPE INCLUSIONS & EXCLUSIONS OF THE STUDY MARKET SEGMENTATION YEARS CONSIDERED FOR THE STUDY CURRENCY Table EXCHANGE RATES UTILIZED FOR CONVERSION TO USD LIMITATIONS STAKEHOLDERS RESEARCH METHODOLOGY SECONDARY SOURCES PRIMARY SOURCES Table LIST OF STAKEHOLDERS INTERVIEWED FOR THE STUDY MARKET SIZE ESTIMATION MARKET BREAKDOWN AND DATA TRIANGULATION ASSUMPTIONS FOR THE STUDY EXECUTIVE SUMMARY PREMIUM INSIGHTS HEALTHCARE FRAUD ANALYTICS MARKET OVERVIEW ASIA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE AND COUNTRY HEALTHCARE FRAUD ANALYTICS MARKET: GEOGRAPHIC GROWTH OPPORTUNITIES HEALTHCARE FRAUD ANALYTICS MARKET: REGIONAL MIX HEALTHCARE FRAUD ANALYTICS MARKET: DEVELOPING VS. DEVELOPED REGIONS MARKET OVERVIEW INTRODUCTION MARKET DYNAMICS DRIVERS RESTRAINTS OPPORTUNITIES CHALLENGES INDUSTRY INSIGHTS INDUSTRY TRENDS MERGERS AND ACQUISITIONS: THE MOST ADOPTED STRATEGY TECHNOLOGICAL ADVANCEMENTS Table COMPANIES OFFERING INNOVATIVE FRAUD ANALYTICS SOLUTIONS NEW USE CASE: OPIOID EPIDEMIC CRISIS END-USER TRENDS: ADOPTION OF HEALTHCARE FRAUD ANALYTICS SOLUTIONS BY PHARMACY BENEFIT MANAGERS HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE INTRODUCTION Table HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) DESCRIPTIVE ANALYTICS DESCRIPTIVE ANALYTICS SEGMENT ACCOUNTED FOR THE LARGEST MARKET SHARE Table DESCRIPTIVE ANALYTICS SOLUTIONS FOR HEALTHCARE FRAUD DETECTION Table DESCRIPTIVE ANALYTICS MARKET, BY REGION, 2019–2026 (USD MILLION) Table DESCRIPTIVE ANALYTICS MARKET, BY COUNTRY, 2019–2026 (USD MILLION) PREDICTIVE ANALYTICS PREDICTIVE ANALYTICS HELPS IN SIMULATING FUTURE EVENTS AND TRENDS THAT CAN ENABLE PAYERS TO PREDICT PREVENTABLE EVENTS Table PREDICTIVE ANALYTICS SOLUTIONS FOR HEALTHCARE FRAUD DETECTION Table PREDICTIVE ANALYTICS MARKET, BY REGION, 2019–2026 (USD MILLION) Table PREDICTIVE ANALYTICS MARKET, BY COUNTRY, 2019–2026 (USD MILLION) PRESCRIPTIVE ANALYTICS PRESCRIPTIVE MODELS OFFER ADDITIONAL ADVANTAGES RELATING TO THE INVESTIGATION OF SUSPICIOUS BEHAVIOR TO GENERATE COMPREHENSIVE INSIGHTS Table PRESCRIPTIVE ANALYTICS SOLUTIONS FOR HEALTHCARE FRAUD DETECTION Table PRESCRIPTIVE ANALYTICS MARKET, BY REGION, 2019–2026 (USD MILLION) HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL INTRODUCTION Table HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) ON-PREMISE DELIVERY MODELS ON-PREMISE MODELS ACCOUNT FOR THE LARGEST SHARE OF THE MARKET Table KEY VENDORS OFFERING ON-PREMISE SOLUTIONS IN THE MARKET Table HEALTHCARE FRAUD ANALYTICS MARKET FOR ON-PREMISE DELIVERY MODEL, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR ON-PREMISE DELIVERY MODEL, BY COUNTRY, 2019–2026 (USD MILLION) ON-DEMAND DELIVERY MODELS CLOUD-BASED DELIVERY MODELS OFFER ORGANIZATIONS INCREASED SCALABILITY AND SPEED Table KEY VENDORS PROVIDING ON-DEMAND SOLUTIONS Table HEALTHCARE FRAUD ANALYTICS MARKET FOR ON-DEMAND DELIVERY MODEL, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR ON-DEMAND DELIVERY MODEL, BY COUNTRY, 2019–2026 (USD MILLION) HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION INTRODUCTION Table HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) INSURANCE CLAIMS REVIEW Table DEPLOYMENT OF PREPAYMENT VS. POSTPAYMENT ANALYTICS SYSTEMS Table HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY COUNTRY, 2019–2026 (USD MILLION) POSTPAYMENT REVIEW Table HEALTHCARE FRAUD ANALYTICS MARKET FOR POSTPAYMENT CLAIMS REVIEW, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR POSTPAYMENT CLAIMS REVIEW, BY COUNTRY, 2019–2026 (USD MILLION) PREPAYMENT REVIEW Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PREPAYMENT CLAIMS REVIEW, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PREPAYMENT CLAIMS REVIEW, BY COUNTRY, 2019–2026 (USD MILLION) PHARMACY BILLING MISUSE FRAUD, WASTE, AND ABUSE CASES IN PHARMACY AND PRESCRIPTION DRUG AREAS TO DRIVE THE DEMAND FOR ANALYTICS Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PHARMACY BILLING MISUSE APPLICATION, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PHARMACY BILLING MISUSE APPLICATION, BY COUNTRY, 2019–2026 (USD MILLION) PAYMENT INTEGRITY CHANGES IN REGULATORY GUIDELINES HAVE AIDED THE ADOPTION OF PAYMENT INTEGRITY SOFTWARE Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PAYMENT INTEGRITY APPLICATION, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PAYMENT INTEGRITY APPLICATION, BY COUNTRY, 2019–2026 (USD MILLION) OTHER APPLICATIONS Table HEALTHCARE FRAUD ANALYTICS MARKET FOR OTHER APPLICATION, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR OTHER APPLICATIONS, BY COUNTRY, 2019–2026 (USD MILLION) HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER INTRODUCTION Table HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) PUBLIC & GOVERNMENT AGENCIES PUBLIC & GOVERNMENT AGENCIES DOMINATE THE HEALTHCARE FRAUD ANALYTICS MARKET Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PUBLIC & GOVERNMENT AGENCIES, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PUBLIC & GOVERNMENT AGENCIES, BY COUNTRY, 2019–2026 (USD MILLION) PRIVATE INSURANCE PAYERS PRIVATE INSURANCE PAYERS ARE FOCUSED ON DEPLOYING ANALYTICS TO COMBAT INCREASING MONETARY LOSSES Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PRIVATE INSURANCE PAYERS, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR PRIVATE INSURANCE PAYERS, BY COUNTRY, 2019–2026 (USD MILLION) THIRD-PARTY SERVICE PROVIDERS ADOPTION OF FRAUD ANALYTICS SOLUTIONS BY PUBLIC INSURERS PUTS PRIVATE BODIES AT RISK, DRIVING ATTENTION TOWARD OUTSOURCING Table HEALTHCARE FRAUD ANALYTICS MARKET FOR THIRD-PARTY SERVICE PROVIDERS, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR THIRD-PARTY SERVICE PROVIDERS, BY COUNTRY, 2019–2026 (USD MILLION) EMPLOYERS EMPLOYERS ARE CONSIDERING FRAUD ANALYTICS SOLUTIONS AS A STEP TOWARD BETTER COST MANAGEMENT Table HEALTHCARE FRAUD ANALYTICS MARKET FOR EMPLOYERS, BY REGION, 2019–2026 (USD MILLION) Table HEALTHCARE FRAUD ANALYTICS MARKET FOR EMPLOYERS, BY COUNTRY, 2019–2026 (USD MILLION) HEALTHCARE FRAUD ANALYTICS MARKET, BY REGION INTRODUCTION Table HEALTHCARE FRAUD ANALYTICS MARKET, BY REGION, 2019–2026 (USD MILLION) NORTH AMERICA Table NORTH AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY COUNTRY, 2019–2026 (USD MILLION) Table NORTH AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table NORTH AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table NORTH AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table NORTH AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table NORTH AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) US Table US: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table US: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table US: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table US: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table US: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) CANADA Table CANADA: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table CANADA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table CANADA: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table CANADA: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table CANADA: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) EUROPE Table LIST OF SOME OF THE EHFCN MEMBER ORGANIZATIONS ACROSS EUROPE Table EUROPE: HEALTHCARE FRAUD ANALYTICS MARKET, BY COUNTRY, 2019–2026 (USD MILLION) Table EUROPE: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table EUROPE: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table EUROPE: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table EUROPE: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table EUROPE: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) GERMANY Table GERMANY: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table GERMANY: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table GERMANY: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table GERMANY: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table GERMANY: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) UK Table UK: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table UK: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table UK: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table UK: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table UK: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) FRANCE Table FRANCE: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table FRANCE: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table FRANCE: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table FRANCE: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table FRANCE: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) ITALY Table ITALY: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table ITALY: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table ITALY: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table ITALY: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table ITALY: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) SPAIN Table SPAIN: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table SPAIN: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table SPAIN: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table SPAIN: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table SPAIN: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) REST OF EUROPE Table ROE: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table ROE: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table ROE: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table ROE: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table ROE: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) ASIA Table ASIA: HEALTHCARE FRAUD ANALYTICS MARKET, BY COUNTRY, 2019–2026 (USD MILLION) Table ASIA: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table ASIA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table ASIA: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table ASIA: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table ASIA: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) JAPAN Table JAPAN: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table JAPAN: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table JAPAN: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table JAPAN: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table JAPAN: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) CHINA Table CHINA: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table CHINA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table CHINA: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table CHINA: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table CHINA: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) ROA Table ROA: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table ROA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table ROA: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table ROA: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table ROA: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) PACIFIC GROWING NEED FOR INSURANCE COVERAGES AND MEDICAL CLAIMS TO DRIVE MARKET GROWTH Table PACIFIC: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table PACIFIC: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table PACIFIC: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table PACIFIC: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table PACIFIC: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) LATIN AMERICA INCREASING PENETRATION OF HEALTH INSURANCE TO DRIVE VOLUME OF CLAIMS PROCESSING IN LATIN AMERICAN COUNTRIES Table LATIN AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table LATIN AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table LATIN AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table LATIN AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table LATIN AMERICA: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) MIDDLE EAST & AFRICA HEALTHCARE FRAUD IS ONE OF THE LEADING CRIMES IN SOUTH AFRICA Table MEA: HEALTHCARE FRAUD ANALYTICS MARKET, BY DELIVERY MODEL, 2019–2026 (USD MILLION) Table MEA: HEALTHCARE FRAUD ANALYTICS MARKET, BY SOLUTION TYPE, 2019–2026 (USD MILLION) Table MEA: HEALTHCARE FRAUD ANALYTICS MARKET, BY APPLICATION, 2019–2026 (USD MILLION) Table MEA: HEALTHCARE FRAUD ANALYTICS MARKET FOR INSURANCE CLAIMS REVIEW, BY TYPE, 2019–2026 (USD MILLION) Table MEA: HEALTHCARE FRAUD ANALYTICS MARKET, BY END USER, 2019–2026 (USD MILLION) COMPETITIVE LANDSCAPE INTRODUCTION COMPETITIVE SITUATION AND TRENDS DEALS Table DEALS, 2018-2021 COMPETITIVE LEADERSHIP MAPPING STARS EMERGING LEADERS PERVASIVE PLAYERS PARTICIPANTS COMPANY PROFILES KEY PLAYERS IBM CORPORATION Table IBM CORPORATION: BUSINESS OVERVIEW OPTUM, INC. (A PART OF UNITEDHEALTH GROUP) 30218549 Single User License: $4,950 Multi User License (5 Users): $6,650 One corporate entity – unlimited locations: $8,150 Global Site License: $10,000
https://www.marketresearch.com/MarketsandMarkets-v3719/Healthcare-Fraud-Analytics-Solution-Type-30218548/
British Art Show 8 | Article index | Articles | British Art Studies An online, open-access and peer-reviewed academic journal for research on all aspects of British art, architecture and visual culture. Articles British Art Show 8 Cover CollaborationbyRoger Malbert Installation view, British Art Show 8, Leeds Art Gallery, 9 October 2015 - 10 January 2016 British Art Studies Editorial Group Roger Malbert Introduction by British Art Studies Editorial Group DOI DOI The “cover” of the first issue of British Art Studies plays with the conventions of the traditional cover of a journal or magazine. A cover traditionally has various functions: to illustrate or give a glimpse into the contents; to protect the pages sandwiched in between; and, occasionally, to conceal rather than advertise what is inside. The digital format of British Art Studies has allowed us to rethink what a cover is and what it can do. We have created more than simply a landing page for presenting text and practical information and made a feature worth visiting in its own right. The cover images selected for issue one do not illustrate any of the articles, but generate a stand-alone feature. For the first issue, we have collaborated with British Art Show 8 Art Historians conference in 2015 contemporary art in Britain between 1945 and 1960 . This collaboration with British Art Show 8 extends this conversation to consider the implications of exhibiting the contemporary under the rubric of “British art”, intersecting with the topic of our Conversation Piece, “There’s no such thing as British art”. by Roger Malbert, Head, Hayward Touring A History of the British Art Show The idea of an exhibition of contemporary British art, touring at five-yearly intervals to different regional cities, was first proposed to the Exhibitions Committee of the Arts Council of Great Britain (ACGB) by the legendary Director of Sheffield City Art Galleries, Frank Constantine, in the late 1970s. The Hayward Gallery, which was run by the ACGB, had initiated a series of influential—and often controversial—Annuals in 1977, focusing on aspects of contemporary art. The British Art Show was intended to offer regional museums and galleries an exhibition of equivalent scale and significance, a survey of current practice selected by guest curators and travelling each time to four different cities. Implicit in the idea from the start was a wish to redress the balance between the capital and the peripheries. As the national funding body, the ACGB was always at pains to demonstrate its regional credentials and even-handedness. It was important that the British Art Show curators were seen to be visiting studios in every part of the country over an exhaustive two-year period of research—even though, as Joanna Drew, then Director of Art, remarked in 1984, they might ultimately come up with a list they could have arrived at sitting around a table in the Arts Council’s offices in Piccadilly in a single afternoon. From the second edition on, London and Glasgow predominated, as they do today. The exhibition has at times been bitterly criticized for its bias in favour of the metropolis and, in the eighties and nineties, a particular art college—Goldsmiths. In retrospect, however, the curators’ choices seem on the whole to have been vindicated: there are relatively few major artists working in this country who have not appeared in one or another edition of the British Art Show. The formula of two or three well-informed guest curators basing their selection on empirical research, focusing exclusively on current activity, with no chance to roam back in time to make historical connections (which many curators are keen to do, as the Tate’s comparatively short-lived Triennial illustrates), has become the show’s signature. An interval of five years is long enough for a new generation to emerge from art colleges and for new tendencies in practice to become apparent. The ostensibly parochial notion of a show confined to British art is mitigated by a loose definition of the criteria, and the fact that over the past thirty years London, the largest city in Europe by far (population 8.63 million, compared to its nearest rival Berlin’s 3.5 million) has been a magnet for artists from across the world. This, combined with the complex legacy of Britain’s imperial history, means that simple ideas of national identity are problematized almost out of existence. What can one say then, about the characteristics of “British art” as they have been revealed by the British Art Show over the past thirty-five years? DOI DOI Reviewing the eight editions of the British Art Show at a glance, certain obvious features stand out. They can be seen to reflect changes in culture, patterns of production, and the growth of new technologies as well as demographic and social shifts. The first edition in 1979 seems comparatively homogenous; the names of the 112 artists included are overwhelmingly English, and only 12 were women. This was a wide-ranging, if partial, painting and sculpture survey show. It includes such major figures as Lucian Freud, Bridget Riley, Richard Long, Michael Andrews, Terry Frost, David Hockney, John Hoyland, Michael Sandle, Euan Uglow, and Sean Scully. As the British Art Show has, over time, registered developments in contemporary art, it has also reflected changes in curatorial practice, moving away from the idea of a neutral survey to a more conceptually considered and “shaped” exhibition: from an over-crowded group show towards a more calculatedly composed, minimalist presentation. The third incarnation in 1990 took a turn away from the cross-generational survey, to focus exclusively on artists under the age of thirty-five. This was a quieter exhibition, with some outstanding contributions from Mona Hatoum, Cornelia Parker, Rachel Whiteread, Gary Hume, Julian Opie, and Callum Innes. As a record of a moment, it affirmed the hegemony of Goldsmiths and consequently provoked an indignant reaction from Julian Spalding. The then Director of Glasgow Museums, where the exhibition opened, publicly denounced it as “not a British art show” (since it was unapologetically partial), and proceeded to organize his own counter-exhibition, The Great British Art Show, with a line-up of figurative painters, including Beryl Cook. Opening a new Gallery of Modern Art in Glasgow, Spalding began to acquire this type of work of popular appeal and resolutely refused to countenance collecting work by emerging Glaswegian artists such as (the now internationally renowned) Douglas Gordon. The conflict epitomized a fundamental divide in Scottish art at that time between those who could be categorized as the provincial populists, and the savvy conceptualists who were performing with confidence on the international stage, and whose work has been acquired and promoted by the Gallery of Modern Art since Spalding’s departure. The British Art Show reached a watershed in 1995, when the exhibition broke away from the confines of a single venue to spread across numerous galleries and exhibition spaces in each city. The standards of presentation (particularly of video and film projections) reached new heights in order to satisfy the requirements of a highly professional and ambitious generation of twenty-five artists, including Steve McQueen, Sam Taylor-Wood, Tacita Dean, Damien Hirst, Chris Ofili, Douglas Gordon, Jane and Louise Wilson, and Mark Wallinger. This was the YBA moment. Plenty has been written about this generation of artists and their influence persists. They have international reputations, are represented by high-powered galleries, collected by museums across the world, and several now live abroad. DOI Figure 15.Photo: Roger Wooldridge, Installation view: British Art Show 7: In the Days of the Comet, Hayward Gallery, London, 2011 Subsequent iterations of the British Art Show have expanded to include many more artists (54 for BAS 5 in 2000 and 50 in BAS 6 in 2005, 22 of whom were women), with a good proportion of each continuing with successful careers. Phyllida Barlow, Martin Creed, Liam Gillick, Michael Landy, Sarah Lucas, Mike Nelson, Grayson Perry, David Shrigley, Wolfgang Tillmans were all in BAS 5; Tomma Abts, Zarina Bhimji, Marcus Coates, Roger Hiorns, Mark Leckey, Goshka Macuga, Zineb Sedira, and Mark Titchner were all in BAS 6—whose co-curator, Alex Farquharson, incidentally, later became the Director of Nottingham Contemporary and has recently been appointed Director of Tate Britain. The challenge he faces there is relevant to the question under consideration here: what, if anything, defines British art? The wise response would probably follow Wittgenstein’s dictum, that the meaning of a term lies in its use, rather than in some essential definition. All of the many thousands of artists living in London, Glasgow, and—increasingly as the capital prices the property-less out of the picture—across the country, would qualify for inclusion, whatever their country of origin. British Art Show 8 British Art Show 8 1 Artists: Åbäke , Lawrence Abu Hamdan , Caroline Achaintre , John Akomfrah and Trevor Mathison , Aaron Angell , Pablo Bronstein , Adam Broomberg and Oliver Chanarin , Andrea Büttner , Alexandre da Cunha , Nicolas Deshayes , Benedict Drew , Simon Fujiwara , Martino Gamper , Ryan Gander , Melanie Gilligan , Anthea Hamilton , Will Holder , Alan Kane , Mikhail Karikis , Linder , Rachel Maclean , Ahmet Öğüt (with Liam Gillick, Susan Hiller and Goshka Macuga) , Yuri Pattison , Ciara Phillips , Charlotte Prodger , Laure Prouvost , Magali Reus , James Richards , Eileen Simpson and Ben White , Daniel Sinsel , Cally Spooner , Patrick Staff , Imogen Stidworthy , Hayley Tompkins , Jessica Warboys , Stuart Whipps , Bedwyr Williams , Jesse Wine , Lynette Yiadom-Boakye . Figure 16. Adam Broomberg & Oliver Chanarin, Trace fiber from Freud's couch under crossed polars with Quartz wedge compensator (#2) , 2015, Digital image courtesy of the Artists and Lisson Gallery, London Figure 17. Linder, Diagrams of Love: Marriage of Eyes (detail), 2015, Digital image courtesy of Linder Sterling / Dovecot Tapestry Studio, 2015. Photo credit, Michael Wolchover. Courtesy the artist, Stuart Shave/Modern Art and Dovecot Studios Ltd. (website) Figure 18. Bedwyr Williams, Century Egg (video still), 2015, Commissioned by the University of Cambridge North West Cambridge Development through the Habitation Artist in Residency Programme managed by Contemporary Art Society and InSite Arts Digital image courtesy of the artist and Limoncello Gallery DOI Figure 19. Mikhail Karikis, Children of Unquiet (video still), 2013-2014, Digital image courtesy of Mikhail Karikis, 2015 DOI Figure 20. Patrick Staff, The Foundation (video still), 2015, Commissioned by Chisenhale Gallery, London; Spike Island, Bristol; Institute of Modern Art, Brisbane; and Contemporary Art Gallery, Vancouver. Co-produced by Chisenhale Gallery, London and Spike Island, Bristol About the author Roger Malbert is Head of Hayward Touring at the Southbank Centre. He studied philosophy, then illustration at the School of Art in Cambridge. He had previously worked Kettle's Yard, Cambridge, as a sessional assistant, then full-time Assistant Curator to Paul Clough. Footnotes Anna Colin and Lydia Lee, "About the exhibition",http://britishartshow8.com/page/about-exhibition-1599 1 Imprint Author Roger Malbert Date 30 November 2015 Category Cover Collaboration Review status Peer Reviewed (Editorial Group) Licence CC BY-NC International 4.0 Downloads PDF format Article DOI https://doi.org/10.17658/issn.2058-5462/issue-01/rmalbert Cite as Roger Malbert, "British Art Show 8", British Art Studies, Issue 1, https://doi.org/10.17658/issn.2058-5462/issue-01/rmalbert PreviousAbstraction’s Ecologies: Post-Industrialization, Waste and the Commodity Form in Prunella Clough’s Paintings of the 1980s and 1990s
https://www.britishartstudies.ac.uk/index/article-index/cover-collaboration/issue-6/alcester-crozier/page/13
The Herko Dialogues: Kyle Bukhari and Yve Laris… | Movement Research One of the world’s leading laboratories for the investigation of dance and movement-based forms. The Herko Dialogues: Kyle Bukhari and Yve Laris Cohen in Conversation On October 27, 1964, Fred Herko, dancer, choreographer and founding member of Judson Dance Theater, leapt to his death from a fourth story window in the West Village, while listening to Mozart’s Requiem. Or perhaps it was another piece of music. And maybe it wasn’t the fourth floor. Beyond the fact of his suicide, and the presumption that is was staged and performed for an unwitting friend, there is much ambiguity around the circumstances of Herko’s death. And, for that matter, his life and works. Herko’s aesthetic entanglements were many—Judson, Andy Warhol, Jill Johnston and more. His dances have been described as campy, romantic, queer, lazy, incandescent, excessive and potentially leading his career nowhere. Or, maybe he knew exactly what he was doing. In the ensuing five decades since his death, many in his Judson cohort have met with praise and, what is more, a secured place in dance history. Herko continues to flicker on the periphery, appearing in photographs or films, alone or with other eventual giants of Judson and Warhol’s Factory. Herko’s elusive status offers unexpected lines of thinking, radicalizing traditional ideas secured within historical narratives. Herko’s presence has embroidered the works of a handful of writers and historians, notably, the late performance scholar José Muñoz in his chapter devoted to Herko, entitled “A Jeté Out the Window,” housed within his text Cruising Utopia: The Then and There of Queer Futurity. Muñoz engages Herko—and his suicide—as a choreographic figure whose movements respond to the contours of queer time, denaturalizing both the theatrical and the quotidian and inviting a kind of utopian performativity into the world. Walking the reader through a profound rumination on the limits of finitude, performance, queerness, utopia, labor and time, Muñoz, points out that this dancer’s final gesture of flight indicates apertures through which we might reflect on escapes from capitalist and historic oppression. On October 25, 2014, almost exactly fifty years after Herko’s death, NYU's department of Performance Studies, in tandem with the Tisch Institute for Creative Research, sponsored a one-day symposium called Fred Herko: A Crash Course . Taking as its premise the fact that no one is an expert on Herko, scholars and art historians presented their biographical research and thought experiments around Herko’s life, suicide and legacy. Critical Correspondence invited eight relative strangers: choreographers, performers, and scholars to attend the symposium and then pair off to reflect on how that day’s discussions about Fred Herko, José Muñoz, Judson and the 1960s coincide with their own artistic and intellectual practices, bodies, and politics today. The meanings of Fred Herko’s life, work and death, and whether such meanings can be consistently deployed, is a central question of THE HERKO DIALOGUES. Yve Laris Cohen: One of the reasons it was difficult to prepare for this conversation is—well, did I tell you I’m co-teaching a course at NYU with Barbara Browning on Judson? It’s in the Department of Performance Studies where José Muñoz taught. I’m also participating in this Danspace Platform organized around the three poles of dance in the 60’s as described by Edwin Denby—one of them being Judson—and so Judson has been heavily in the brain this fall. Herko in particular has been on my mind as we focus on José’s legacy. I feel very saturated in this material. It’s been a different kind of encounter than just attending the symposium. What about you? Kyle Bukhari: It sounds like you are deeply contextualized within the material surrounding Herko. My knowledge of Judson comes particularly through my research on Yvonne Rainer, and looking at some of her works within a philosophical context. My recent research has focused on Rainer’s Hand Movie[1967] and Richard Serra’s Hand Catching Lead[1968] looking at them as examples of intermediality encompassing dance, sculpture, and film. That’s what I was doing in London this year which is pretty ironic since I went to there to work on Michael Clark’s work but ended up writing on downtown New York postmoderns—that’s how things happen I guess. I’ve also done work on Rainer’s We Shall Run[1963] so that’s more where I’m tying Fred Herko in—to this early Judson work. For me, this symposium was fleshing out an obscured, darkened area, and shining some light, like a flashlight, across it, briefly illuminating the silhouette of Herko. YLC: I feel like we still don’t have the flesh after that symposium. KB: Yes absolutely, it’s quite elusive still. YLC: Or not even bone. KB: That’s true. That’s this absence, or rather a sort of absence/presence—trying to make something out of very little in many ways, an act of critical recovery—but on the other hand, he was there; it was substantial. He created work in some of the first concerts at Judson. You probably know more about this than I do.. YLC: But you know, even with Sally Banes’s detailed descriptions and her very clinical, deliberate, seemingly matter-of-fact summaries—although her own biases come through—Herko still somewhat slips away from these plodding accounts. But, paired with José’s [Muñoz] take on Herko’s dances, they give me some sense of his work. The symposium didn’t really consider his cultural production as much as his death—although that can also count as production. In many ways I’m more interested in his death and how people take him up rather than being faithful to the person, Fred Herko, and his life. Of course, Gerard Forde would take major issue with that. KB: The precision, the empirical, verifiable fact. Gerard was really fighting for that. So, we had these different speakers, each approaching the symposium from different angles, not necessarily focusing on Herko’s work but circumnavigating it. YLC: Danielle Goldman spoke on the “elegant lines of Fred Herko.” But it was very much building on José’s work. KB: I liked this idea of Goldman’s that lines have history and weight. So this is building on José’s work? I’ve read his essay A jeté out the window, but I’m not familiar otherwise with José’s work. Have you gone through it a bit? YLC: Yeah. You know, I thought this conversation would carry us toward José because, for me, José makes Fred Herko important. And not so much in the sense that Freddy Herko was written out of history and we need to rewrite him back in—that’s more Forde’s project. For José, Herko becomes this figure that is in support of José’s broader project. Barbara made this point in class. KB: He plays a certain role within José’s larger project—or he fits neatly into it? YLC: Well yeah, it’s not about rounding out a picture of Freddy or “fleshing out” or connecting the dots. It’s more about using ephemera, the bits that we know about, his traces—José doesn't corral all the dots but picks up a few in service of his work on queer futurity. And that, to me, is more interesting than trying to holistically examine Fred Herko's oeuvre. Herko is now more important to queer theory than he is to dance scholarship. KB: Foucault has this great essay called The Lives of Infamous Menand this project has made me think of it, although Herko’s work, I mean, he’s more than infamous in that there is quite a bit of documentation. Foucault wrote about looking through the archives at the Bibliothèque Nationale—internment records from the 1800s—and discovering a few lines about somebody’s imprisonment and then drawing a whole history out of that. I’ve got a quote here: “The resonance that [one] experiences when he encounters these lowly lives reduced to ashes in a few sentences that struck them down.” And then Foucault talks about using these few lines to think about the institutions and the forces at work that surround this individual prisoner. He has this idea of the beam of light that illuminates—I see it like shining  a flashlight into the past—exposing this larger scenario, but at the same time he calls attention to the whole investigative production behind the act of bringing someone from the past to life. There’s this creative aspect that is perhaps disconnected from the verifiable, empirical facts that Gerard is rightly concerned with, but which also has its place. They’re sort of two different projects right? YLC: Of course. KB: There’s this historical, empirical perspective, and then there’s this more theoretical kind of practice. Each with different purposes and functions.  So I was just fascinated thinking about that, how the symposium and this reexamination are kind of making the tension between these approaches visible. Also to think about what we are doing within a larger framework in accessing the archive. Derrida’s “Archive Fever” is quite on point here which I think you may have read. YLC: Yes. KB: He does this really cool genealogy tracing the etymology of the word ‘archive’. He traces it back to the Greek word archeon, which means house, and how it was the house of the archons, the superior magistrates of the society at the time. They possessed the right to make the laws and it was in their house where the official documents were kept. And this is how Derrida sets up thinking about the archive and its power. So I was thinking about how we’re also dealing with the Judson archive. The power of it, and how it shapes the platform from which order is given in subsequent inquiry, discourse and production.. This is the idea that Derrida proposes. YLC: And so with Judson we have an incomplete archive displaced from its house. Coincidentally, the titles of the four pieces I’ve made for Movement Research at Judson include either the word “house” or “home.” With that I was thinking about how we narrate our origin story as downtown dance people. “Home” necessitates a return. Or escape. Movement Research’s Monday series [at Judson Church] has far outlasted Judson Dance Theater, and I wonder how the accrual of Monday performances in the church, since 1991, is recasting the historic Judson Dance Theater. Something Herko illuminates is the asymmetrical treatment of the Judson artists in this moment where that era in dance is being “rediscovered” and rigorously historicized for the first time, and how the active curation of living artists plays a huge role in this reformulation of the 60’s Judson archive. The way the artists are curated now in 2014 affects how we digest their 60’s work and construct the broader Judson story. Yvonne Rainer is making new work at the same time as she’s having a zillion retrospectives. And Steve Paxton—the same thing. And Simone Forti— KB: —in New York, in London. YLC: Everywhere! And who else? Trisha Brown, certainly. And in the meantime, Fred Herko can only be given a one-day symposium that talks around him, and his works can’t be remounted, especially given the nature of his ultimate work. I almost said “final work,” but I don’t want to betray José’s idea about the choreographing of a suicide being a queer utopian gesture because it reaches beyond the finality of that moment—that, bracketed as a performance, Herko’s suicide negates the finitude of death through what José calls “radical negativity.” Still, Herko’s inability to be curated is exciting to me as far as the ends of reproduction. Queer non-reproduction is one thing, but then there’s refusal—which is also a queer strategy, and maybe Herko’s meta-strategy within Judson. Even now, his dances are refusing to be revived. So you know, José talks about ornament, ornamentation, and flamboyance, and excess, and those being part of Herko’s queer aesthetic that was in opposition to, or resisting, or other-than the prototypical postmodern dance model of you know, “pared-down”— KB: —the everyday, the minimalist— YLC: Sure. So, José presents Freddy’s work against this supposed Judson aesthetic monolith. Like queerness, for José, Freddy’s work is “something else.” I think there’s something else happening in Freddy’s work than “something else.” One reason has to do with the assumption of this so-called minimalist monolith. I don’t think that’s what Herko’s aesthetic, with its particular modes of excess, was refusing. Freddy also wasn’t alone in deploying camp: David Gordon, for one, took that tack. Freddy’s suicide does make me go back and read his “ornamented” dance pieces differently, though. That might not be fair. But as an artist, I do think there’s something to the idea of honoring a fellow artist’s full practice. And in this case it likely encompasses his suicide, so we have to talk about it, right? KB: Absolutely. YLC: But to what extent do we have to honor him, actually? In discussing him. KB: Good question. For me the question right now in thinking about his suicide is does his suicide eclipse his oeuvre? The Italian Filmmaker, Pier Paolo Pasolini, said that death is the final editor—it makes us retrospectively reevaluate a person’s life—it attains this kind of crispness in death and I think this is definitely in effect in Herko’s case. My question still, though, is, does his death overshadow his body of work? Or, in some ways, because there is so little documentation of it—I keep thinking about Yvonne Rainer, you know, she’s got so little video documentation of her work from that period. YLC: Well— KB: —she told me once after a performance at Dia:Beacon that all the works from that period were lost. But perhaps you’ve seen some things that I haven’t seen! YLC: But then does the saturation of documentation of Trio A, now in its many 21st-century manifestations, overpower the 1960s lack of documentation? We forget that there was no documentation then, you know? KB: Yes, good point. YLC: And certainly the Judson performances are chronicled in Jill Johnston’s writing, and others’— KB: —of course, and Deborah Jowitt—but I am thinking about what Carrie Lambert-Beatty writes in Being Watched, about how our perceptions are informed by the photographic archive, and that we have to consider the double mediation from the work to the film, and back to live work again. YLC: I’m curious about how Yvonne’s Hand Movieties in for you, especially given that it was post-Judson Dance Theater. KB: Well Hand Movieis definitely well after Herko’s death—but there is an interesting connection between them. I was looking through the symposium program and Rainer and Herko shared concerts where it was just the two of them—I think in 1964. I’ve also been thinking about her so-called No Manifesto, which she of course later refuted—but. there are a few lines that stood out to me when considering Herko’s case: “No to transformations and make believe. No to the glamour transcendency of the star image. No to trash imagery. No to camp. No to eccentricity.” I’m rethinking to whom or to what she  was responding, if Herko’s work might be somehow causal to the aesthetic stance she took. Herko was certainly not the only person that was working like this, but still considering his proximity to her, it is striking. YLC: I’m so glad you brought that up. This is a question I actually want to ask Yvonne. It occurred to me as I was in class with my students and Barbara: the No Manifesto and Yvonne’s work in general are so often read as refusing previous dance traditions, as rejecting ballet, rejecting— KB: —Cunningham. YLC: Cunningham, but also Graham and other modern forms, but I guess most recently Cunningham. Although, Judson artists certainly took up Cunningham’s project in some ways, mostly via the Dunns [Judith and Robert], of course. But after looking at all the semester’s material I thought, Oh, is Yvonne actually talking about her contemporaries? Is the No Manifesto actually a side-eye toward other Judson artists, including Herko? Maybe especially Herko? I mean, what’s so funny about “no to trash imagery” is that the most striking, beautiful footage of Herko is him watering those trash cans in Elaine Summers’ film. KB: Totally! YLC: And so Herko lets us read the No Manifesto in a more nuanced way, and we can remember Yvonne wasn’t isolated within the Judson era. And that friction amongst your peers is a necessary part of art production. KB: It sounds like, if anything, it makes those early Judson concerts sound even richer and not yet solidified into this conception of Judson postmodernism, but rather as a much more complicated and pluralistic aesthetic idea. The term post-modern is a contested idea. Susan Manning has really criticized Sally Bane’s use of the term, you know, whether you do it with a dash or not, and that postmodernism in dance does not line up with postmodernism in visual art. YLC: Yes. Dance being out of time with the trajectory of visual art movements, and those being out of time with the progression of capitalism; modernism and modernity being misaligned, and now late modernity and postmodernism being misaligned. So what do you do with Herko, a figure who is out of space and time with dance, which is itself, as a discipline, out of space and time with art, which is struggling in late capitalism. KB: Well that’s interesting how you just said that dance is a discipline outof space and time. The materials of dance are space and time, in a way. So is it made of space and time? Or how did you mean that? I’m curious. YLC: In the way that José talks about Ernst Bloch’s formation of temporality, building on Marx. And I’m going to butcher this— KB: —you’re not an Ernst Bloch scholar? YLC: Ha, no. KB: The surplus value produced by workers estranged from their labor and its transformation into the aesthetic right? YLC: Right. But Bloch also talks about how people in different subject positions don’t just experience time differently in a perceptual way—they are literally in their own time, falling in or out of dominant time. Bloch draws those fault lines mostly around class and age. José brings in race, gender, sexuality, disability. He talks about “straight time” and the bodies that fall out of or slip away from that. It’s racialized bodies, it’s queer and trans bodies, it’s disabled bodies. Straight time isn’t just the heterosexual subject’s time; it’s the stand-in for this normative stricture that governs our lives within late capitalism. KB: It’s the hegemonic time. YLC: Yes. And he talks about a slowing or delay. And while queerness has been thought through as arrested development, José does something much more complex. It’s not just this slowing or delay, it’s something else where. He brings in space. Queer time has been worked on for a while now, but trans temporality has just begun to be theorized. José mentions transpeople but only in this laundry list of bodies that don’t fit into straight time. Transness is folded into queerness, but isn’t specifically articulated. In my own work I’ve been thinking through how time gets curvaceous. How it gets distorted. It’s not just a slowing, or being somewhere else in space-time, but there’s this bubbling, ballooning, that happens through suspension. Or the ballooning creates the suspension. That’s the image that helps me. It's not stretched laterally like taffy. Especially because now the slowing of time has all these new-age associations: Slow Food, appropriated versions of meditation and yoga, “slow down” in Papyrus typeface. You can get a clear idea of the marketing image. Slowing down is not so useful for me. KB: Time is kind of commoditized. YLC: Totally. Paradoxically, it's become about slowing down in order to more effectively and efficiently consume. Slowing time is super hip within visual art performance discourse right now. And aside from my aversion to the fashion of it, it’s not feeling like it has much political potential anymore. What do you think? KB: About slow time? About slowing down? About just the temporal in general? YLC: Any of it. How does it fit into your work? KB: I mean, I’m interested in the spatio-temporal in terms of aesthetic materials. I’m very interested in the materiality of time and space and how one can crystallize that in a work. It’s really incredible when it functions and you’re able to perceive that—how a work can make one aware of time and space in a way that is not normally possible. The poetics of it I guess. YLC: That’s interesting that you say crystallize because already that implies a kind of physical compression—doing something material tospace and time. KB: Yes, I think it is. I saw this great piece by Anne Teresa de Keersmaeker/Rosas, called Vortex Temporum. In the piece, she has the dancers and musicians all playing musical instruments together as they slowly circulate around the stage—even the piano is moving. The musical group is called Ictus — fabulous musicians. And the whole thing was circling. At a certain point, the direction reverses and goes the other way. I had a moment there when I really started to understand what this activity was doing to time and space; I was seeing how this aesthetic production was kind of like [makes a screeching noise]. Through the arts, how one can tweak time and space and show that it is a malleable material in a way. YLC: And one question I have, just in my own work and thinking, is, how can dance’s space-time distortion transcend its role as an experience that an artist is delivering for an audience member, within the parameters of the performance? And I'm not talking about expanding or changing those parameters, although that's one way to do it. So, the audience has this cool experience of time for an evening and then everyone goes home and everything’s as it was before. How can our work actually restructure the way we live? “We," including both artist and audience. I don’t know if art can or should necessarily do that, but it’s a helpful proposition for me. KB: Well you’re pointing to the way that the arts are displaced from everyday life. They’re separate. In the visual arts, they’re in a highly commoditized realm, right? You know, sort of luxury goods, luxury market. Dance, not so. It still has resisted to some extent. YLC: Well, it depends who you’re talking about. KB: I guess the New York City Ballet. YLC: Judson has currency. Is currency. KB: It’s very complicated and really interesting to think about how experimental performance art—I mean, yeah—at some point resists commodification, and on the other hand, it is brought to the museum to increase foot traffic, to increase visitors, it’s got a real draw. It’s a real draw also for the object-based arts; it really enlivens them in many ways. YLC: One frustration I have with the way performance is often curated in a visual art context is how it’s just brought in to enhance your experience of the saleable works. Performance is called upon in “activating the space,” or, “activating the objects,” or, what did you say, “enhancing”? KB: Enlivening. YLC: Enlivening! Yes. This idea that performance provides an ultra-sensorial experience that awakens us to consume better. I told my students last week in class—and this is all hearsay because I wasn’t even at this talk—but there was this performance symposium at MoMA few years ago where Judith Butler and Shannon Jackson were delivering the keynote. I guess, in response to a question about the role of performance now, Judith Butler talked about the “de-deadening of the senses.” David Velasco found that interesting and wrote me about it, but I misread his text as saying the “ deadeningof the senses.” I was so excited because that sounded like an antidote to all of this yoga talk around being “totally present” and awake and alive in “in the moment”. Coming back to José: he’s talking about the “here and now” is a normative constraint—he actually calls it a “prison house.” He says we need to be thinking, feeling, a "then and there”. There’s a built-in rejection of this impetus to “be present.” Dance pedagogy pressures us to be “in our bodies.” This has a built-in temporality wrapped up in the present, so it really means, “be in your body in the here and now.” Coming from my perspective as a trans person and my investment in disability studies and crip theory, I find this directive to be incredibly oppressive. It can only really address certain dominant subject positions. But anyway, with my misread of “de-deadening of the senses,” I was thinking, Oh! Judith Butler is talking about a retreat from being the best-sensing organism possible. Here I thought she was valuing degeneration or sensory shutdown. Or getting deader. KB: It’s really interesting how you sketched that out—how you think about the body and these unrealistic and counterintuitive expectations for our senses—and how we force ourselves into the temporal embodiment of  these individualized, atomic, separated bodies. One way that I’ve come to understand the body is how it is constituted by the social, how our conceptions of the body are socially and historically constructed. The historicity of the body—this is how Dominic Johnson frames Herko’s suicide in Modern Death.And bringing this back to Herko—I don’t know if you had any thoughts on this—but this idea of Herko as a balletic presence within Judson. YLC: That is exactly what I wanted to talk about! KB: And what about that? That is a very strong position he was taking amidst the everyday aesthetics of his Judson colleagues. KB: The film that we saw at the symposium where he was dancing with Jill Johnston— Jill and Freddy Dancing[1963, Andy Warhol].. He is doing tours en l ’air, and chassésto a perfect fifth position. He’s not at all trying notto do that. He is totally embracing his ready-made ballet dance vocabulary. I’m thinking of the Raindeers, Yvonne Rainer’s current company, and Emily— YLC: —Emily Coates. KB: Emily Coates brings in the use of this ready-made ballet genre to Yvonne’s more recent work. In a way, he was also embodying that. YLC: And it didn’t feel completely parodic. At least in the glimpses we have in Jill and Freddy Dancing, his ballet dancing feels pretty sincere. There’s a wink, definitely, but we can detect a kind of love for the form. I could be projecting. Another thing: in José’s essay, when he quotes Steve Paxton, or "Bill Paxton"— KB: Which I still don’t fully understand YLC: I really love that typo, so much. KB: Is it a typo? YLC: It’s an oversight that I think is great. So, Paxton says about Herko’s work, “You would get some ballet movement, none of it with very high energy.” This is what interests me most in Herko’s dances. Low-energy ballet. It’s a really exciting proposition, as a kind of resistance. Deflation. Evacuation. Maybe even disembodiment. These can be queer strategies too. They’re certainly trans survival strategies. I’m more compelled by this formal choice of Herko’s than the camp and ornamentation and flamboyance that José foregrounds. KB:  This makes me think of the complete reduction and decomposition of the balletic form in [William] Forsythe’s Decreation[2003] as the kind of end to this trajectory launched by Herko — he appears to have been absolutely contemporary in that way.  But I didn’t mean to interrupt you. What does Paxton say after that? Because I’m also thinking about Paxton—and different queer strategies taken up by Herko vis à vis Paxton. Does he mention camp? YLC: In the first sentence of the quote, “It seemed very campy and self-conscious, which wasn’t at all my interest.” My last point about the low-energy ballet is just about Freddy Herko being pre-queer or proto-queer, before the onset of the gay liberation movement. José talks about this at the end of his essay, which is so gorgeous and devastating and—just drops off. That last page gives me chills. His final sentence: “Would being gay have made his utopian and vexed queerness any easier or more painful?” The fact that Herko’s not-yet-gay makes him queerer and more contemporary, in the way that queerness is other than mainstream gay political strategy. And “not-yet” is endemic to queerness anyhow, says José. KB: Also, this proto-queerness that you mention, this ballet dancer descending from the more elite uptown to a more decrepit downtown, this low energy ballet—Herko’s got this one piece Once or Twice a Week I Put on Sneakers to Go Uptown [1962]that highlights this interesting uptown/downtown tension, and I think there was a lot  at stake for him in the transgresssive movement from uptown to downtown. YLC: Right. I’m just thinking of how we organize uptown and downtown dance today and how there’s this kind of nebulous category that was encapsulated by Dance New Amsterdam [a dance studio formerly operating in lower Manhattan], rest in peace. DNA was a hub for this dance sensibility that’s not quite uptown or downtown, and I wonder if Freddy would have been engaged with that. KB: That’s a good question. I’m just reflecting on this film with Jill Johnston and Herko and wondering if predates a kind of disdain for ballet as an elite uptown form. It seems like it was no problem that Freddy was arabesqueing about or chasséing in fifth position. It’s almost as if everything was allowed and novel in a way. I wonder if these kinds of positions between uptown and downtown dance were just forming then. YLC: Yeah. Doesn’t that film feel like it could have been shot at an AUNTS evening today? KB: Absolutely. YLC: On a rooftop in Bushwick. KB: What do you think about the camp aspect? YLC: First, I think it’s maybe a misnomer. Too often, the work of queer artists is pigeon-holed in the domain of camp, even if it’s not their intention. I’m thinking of Susan Sontag’s essay. KB: Yes —her Notes on Camp—these are a dense proposition. I pulled one quote which I thought worked for us, which is: “camp, any sensibility which can’t be crammed into the mold of a system, something that can’t be hardened into an idea”. Sontag seems to be saying that camp resists reification; it’s a very protean thing, very shape-changing in a way. And when I think about the force of the minimalist aesthetic, it seems to really have taken a kind of priority at Judson and then I think about— YLC: —could we pause for a moment on “minimalist”? One thing that gets to me is the way it isn’t correctly transposed. KB: From object arts to performance arts? YLC: Yeah. YLC: Yeah. Well just that capital “M” Minimalism within visual art is a discrete art movement with discipline-specific characteristics. The word “minimalism” doesn’t easily move from that context to dance and mean similar things. It can’t map onto dance as a neat transposition. KB: This is something that I’m interesting in within aesthetics—how the same concepts and ideas play out in different media. YLC: Using this same word across disciplines ignores the specificity of the different disciplines’ toolboxes. Many so-called Minimalist sculptors have rejected that word, which art historians applied retroactively. Within music, Phillip Glass says, “I’m not a minimalist composer. I make repeating structures.” And yet, every fourth New Sounds broadcast announces, “Today’s show features minimalist piano works.” Which is essentially Phillip Glass and friends. It’s now accepted as both a form and genre. When I think of the genres that Judson Dance Theater initiated, there are all these ways of working now that have been dislodged from their parent decade. “Task-based” is something that is no longer specific to the 60s—it’s a way of working that anyone can take up now.  Working with tasks is just one of many things you can choose from as a dancemaker today, and if you decide to do something task-based it doesn’t mean you’re necessarily quoting Judson. Anyhow, I think we should uncouple “minimalist” and “postmodern” in dance, don’t you think? They’re often said in one breath without any interrogation KB: I think so yes—minimalism is one among many aesthetic propositions within dance postmodernism that in effect let everything in and allowed it to be seen as dance. YLC: Well, pastiche! KB: Pastiche, right. From what I understand the pastiche comes in later as second stage postmodernism. And the first stage of postmodernism within dance history seems to have tended towards the minimal, the body as material, task-based operations and working with objects. YLC: Fantastic Gardens[film by Elaine Summers, 1964] involves pastiche, though. KB: That’s true. Stunning film! YLC: Just one last thought. Coming back to the Derridian trace and how we interpret Herko’s traces; how it’s obviously impossible to read José’s work on Herko without acknowledging José’s death and this essay being one of his traces—albeit a very robust trace—how that makes me think through Herko differently, how I read this essay differently when José was alive than when I read it now—and how their deaths are kind of paired. What that means, I don’t know. I’m still figuring it out. KB: Well it’s quite recent also. I did not know José. YLC: He was on my thesis committee when I graduated from Columbia. I had asked him to be on it during a performance and choreographed that proposal. But you know, I was obviously not nearly as close to him as were a lot of NYU students and his colleagues in the Performance Studies department. It’s a heavy thing to be teaching there now and feel the grief of that department; it’s palpable. His absence is really felt right now. It’s weird to read about utopia with this—sadness. And I think that people are misreading his work because of it too. There’s a kind of romanticizing of José’s utopianism that’s happening: a misreading of it as optimism, which is different than utopian thinking. Utopian thinking is politically strategic instead of again, this new-age, “everything will be just fine,” self-help modality, which breeds complicity. KB: So, optimism as a kind of denial whereas a utopian vision is more politically strategic in that you’re voicing this alternative future. YLC: And he talks about the difference between optimism and hope. As we celebrate José’s life and work, we have to hold on to his own sadness too, and not flatten the complexities of his writing. His own ambivalence is an important part of his work—his book isn’t just a manifesto. And—I think I’m going to end on that. KB: There’s this tragic rhythm from Herko’s death to José’s death and the fact that we’re looking at them both now is quite remarkable. Fred Herko: A Crash Course was co-presented by the department of Performance Studies (NYU), the Tisch Institute for Creative Research, Women & Performance: a journal of feminist theory and the Goethe-Institut New York, with associated programming provided by New York Performing Artists Collective. Filed under: Conversations Keywords: Fred Herko, Judson Dance Theater, Kyle Bukhari, queer performance, The Herko Dialogues, Yve Laris Cohen
https://movementresearch.org/publications/critical-correspondence/the-herko-dialogues-kyle-bukhari-and-yve-laris-cohen-in-conversation
ab15e99719a00722e0b593aa51cc5c52a68fdc6b5fa15035cc07f1dc4a2997ff_optim.pdf Instruction Manual for ACU-RITE models including: Indoor or Outdoor Clock, ACU-RITE Indoor or outdoor clock with temperature and humidity 00914 instructions indoor, outdoor, clock, temperature, humidity, clock AcuRite Indoor or Outdoor Clock - AcuRite Instruction Manual Indoor or Outdoor Clock with Temperature & Humidity 1 2 Set the Time . Turn the set knob on the back of the clock in either direction. Document: Text References File Info : application/pdf, 4 Pages, 654.44KB analog-clock-temperature-humidity-instructions Instruction Manual Indoor or Outdoor Clock with Temperature & Humidity ·1 Set the Time Turn the set knob on the back of the clock in either direction. ·2 Install or Replace Batteries AcuRite recommends high quality alkaline or lithium batteries for the best product performance. Heavy duty or rechargeable batteries are not recommended. The clock requires lithium batteries in low temperature conditions. Cold temperatures can cause alkaline batteries to function improperly. Use lithium batteries in the clock for temperatures below -4ºF / -20ºC. Insert 1 x AA alkaline or lithium battery into the battery compartment, as shown. Follow the polarity (+/-) diagram in the battery compartment. DO NOT HANG IN DIRECT SUNLIGHT! For the most accurate temperature readings choose a location that will not be exposed to direct sunlight or other direct heat source Placement for Maximum Accuracy AcuRite sensors are sensitive to surrounding environmental conditions. Proper placement of both the display unit and the sensor are critical to the accuracy and performance of this product. LOCATE AWAY FROM HEAT SOURCES Position clock away from heaters, air conditioners, chimneys, exhaust vents, asphalt and concrete (surfaces that radiate heat). 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HOTEL REOTIER : Hotels near Réotier 05600 France HOTEL REOTIER : Find the best hotel among all the hotels near Réotier and BOOK NOW for your trip in France ! 05600 Hautes-Alpes Hotel Réotier Réotier Hotel Road map Map Photos Weather Population Housing Here is the list of the hotels near Réotier. Book your hotel near Réotier today, Saturday 24 June for the best price, reservation and cancellation free of charge thanks to our partner Booking.com, leader in on-line hotels reservation. To help you find available hotels, you can follow these links to check the list of hotels in nearby towns of Réotier : - hotels near Mont-Dauphin : town located at 2.29 km - hotels near Saint-Clément-sur-Durance : town located at 2.73 km - hotels near Eygliers : town located at 3.16 km - hotels near Saint-Crépin : town located at 4.18 km - hotels near Risoul : town located at 4.26 km - hotels near Guillestre : town located at 4.55 km - hotels near Champcella : town located at 6.14 km - hotels near Châteauroux-les-Alpes : town located at 8.56 km - hotels near La Roche-de-Rame : town located at 8.78 km - hotels near Vars : town located at 9.96 km - hotels near Freissinières : town located at 10.35 km To help you choose your destination as well as the place of the hotel here is: - pictures of Réotier : photo Réotier - the map of Réotier : map Réotier - the road map of Réotier : road map Réotier Below here is the list the 50 closest hotels of Réotier, sortable according your criteria. 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Sort hotels by : Most popular Distance between hotel and town hall Price (increasing) Price (decreasing) Number of stars (increasing) Number of stars (decreasing) -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- L'Auberge d'Eygliers Hotel Eygliers L'Auberge d'Eygliers is located in Eygliers, part of the Queyras Regional Nature Park, and on the edge of the Ecrins Regional Nature Park. The Montdauphin Fortress, a UNESCO world heritage site, is just a 5-minute drive from the property. This hotel is equipped for guests with a hearing or visual impairment. The rooms are soundproofed and offer free WiFi access. The private bathrooms come with a shower. A continental breakfast is served each morning, and a gourmet breakfast is also possible upon reservation. The meals are prepared by the chef Marcel with fresh and local produce. Guests can also enjoy homemade organic cocktails in the hotel’s bar. At L'Auberge d'Eygliers you will find an ayurvedic massage service. Other facilities offered include meeting facilities. The property provides free private parking, a motorbike garage and ski storage. It is a 25-minute drive from Risoul Ski Station. Montdauphin - Guillestre Train Station is 300 metres away. Price : from 58.50 € to 94.00 € Hotel Réotier : Address : Quartier de la gare 05600 Eygliers Distance on map, Hotel - Réotier : 1.78 kilometers Number of room : 11 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Hôtel Lacour Hotel Eygliers At the foot of Montdauphin Fort, Hôtel Lacour is located only 50 metres from Montdauphin-Guillestre Train Station. Vars Ski Station is a 35-minute drive away and Risoul Ski Station is a 20-minute drive away. Each room features free Wi-Fi access, a TV with cable channels and the majority have a private bathroom. The brasserie-style restaurant is open each lunch and evening and offers traditional cuisine with a large choice of wines. The Hotel Lacour offers a garden, meeting room and free private parking on site. Hiking is possible in the area and ski shuttles depart from the hotel to take guests to the ski stations. Prices : from 63.00 € to 105.00 € Hotel Réotier : Location : Rn 94 Mont-Dauphin Gare 05600 Eygliers Route on map, Hotel - Réotier : 1.79 kilometer Number of rooms : 46 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Holiday Home & Spa - Le Rendez Vous de Vauban Guest accommodation Mont-Dauphin Located in Mont-Dauphin, Le Rendez Vous de Vauban is 6 km from Risoul. It offers a hot tub, a steam bath and self-catering cottages with free Wi-Fi access. A fitness room is also available. Each cottage at Le Rendez Vous de Vauban offers a washing machine, a seating are and a bathroom with a shower or a spa bath. They provide views of the Massif des Écrins. A kitchen with a fridge, an oven and a stove is included in each cottage. There is also a coffee machine, kitchenware and a microwave. Guests can go hiking, skiing and horse riding in the area and free public parking is available on site. Guest accommodation Réotier : Address : Place de l'Arsenal 05600 Mont-Dauphin Distance on map between hotel and center of Réotier : 2.29 km Room in hotel : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Gite-Auberge Le Glacier Bleu Guest accommodation Mont-Dauphin Offering a children's playground and ski storage space, Gite-Auberge Le Glacier Bleu is set in the walled city of Mont-Dauphin in the Provence-Alpes-Côte d'Azur Region, 38 km from Sestriere. Guests can enjoy the on-site restaurant. Every room has a private bathroom fitted with a shower. Gite-Auberge Le Glacier Bleu features free WiFi . You will find a gift shop at the property. The area is popular for skiing and horse riding. The guest house also offers bike hire. Bardonecchia is 46 km from Gite-Auberge Le Glacier Bleu, while Pra-Loup is 33 km away. Price : from 72.00 € to 84.00 € Guest accommodation Réotier : Location : Rue Catinat 05600 Mont-Dauphin Distance between hotel and center of Réotier : 2.31 kms Rooms in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Auberge de L'Echauguette Hotel Mont-Dauphin The Auberge de l'Echaugette is located in the heart of the Vauban citadel in the Hautes Alpes region. The inn offers free Wi-Fi access and a traditional restaurant offering regional cuisine. Each guest room has its own theme and all rooms are comfortable and soundproofed. The Auberge de l'Echaugette is set in wooded mountains that extend to the borders of the Guil and Durance valleys, close to many ski stations including Vars, Serre Chevalier and Puy St. Vincent. In the summer, there are many sporting activities nearby, such as waterskiing, whitewater rafting, rock climbing, aviation, cycling and hiking. Prices : from 70.00 € to 185.00 € Hotel Réotier : Address : Catinat 05600 Mont-Dauphin Distance on map, Hotel - Réotier : 2.31 kilometers Number of room : 13 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Le Pavillon des Officiers Guest accommodation Mont-Dauphin Located in Mont-Dauphin, Le Pavillon des Officiers offers self-catering accommodation. Guests have use of a shared garden and a patio with mountain views. All apartments include a dining area and a TV. There is a fully-equipped kitchen with a microwave, a stovetop and a refrigerator. The private bathroom comes with a shower. Activities in the surrounding area include cycling and hiking. The property is located between the Ecrins National Park and the Queyras Natural Regional Park. Le Pavillon des Officiers is situated 17 km from Risoul Ski School and 21 km from Vars Ski School. Grenoble Airport is 190 km from the property. Guest accommodation Réotier : Location : Place Forte Vauban 05600 Mont-Dauphin Route on map, Hotel - Réotier : 2.33 kilometer Number of rooms : 17 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- La Bourrassee Bed and Breakfast Saint-Clément sur Durance Situated in Saint-Clément sur Durance, La Bourrassee features accommodation with a balcony and free WiFi. The accommodation is 25 km from Vars. The bed and breakfast includes a kitchen with a dishwasher and an oven, as well as a coffee machine. A continental breakfast is served every morning at the property. The bed and breakfast offers a barbecue. Skiing and horse riding can be enjoyed nearby. Briançon is 39 km from La Bourrassee. Bed and Breakfast Réotier : Address : Hameau les Clots 05600 Saint-Clément sur Durance Distance on map between hotel and center of Réotier : 2.77 km Room in hotel : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- La Source Chambres d'hôtes et gîtes Bed and Breakfast Risoul Set in a renovated farmhouse with a small garden, this guest house offers views of Mont Dauphin and the Ecrins Mountains. Risoul ski resort is 12 km away and a continental breakfast is prepared daily. A mountain or garden view and antique furniture are offered in the guest rooms and free Wi-Fi access is provided. The kitchen includes an oven, microwave and a fridge-freezer. Breakfast is available for guests staying in the guest rooms. Mont Dauphin Train Station is 5 km from this guest house and you can travel to Lake Serre-Ponçon, 15 km away. In winter, there is a free shuttle service to take you to Risoul ski resort, 25 minutes away. Prices : from 85.00 € to 145.00 € Bed and Breakfast Réotier : Location : Quartier Chauvet 05600 Risoul Distance between hotel and center of Réotier : 3.03 kms Rooms in hotel : 4 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Gîtes La Source Apartment Chauvet Featuring free WiFi and mountain views, Gîtes La Source offers accommodation set in a renovated farmhouse in Chauvet. Sestriere is 39 km away. Free private parking is available on site. All units have a seating area. Some units include a terrace and/or balcony. There is also a kitchen, fitted with a dishwasher, microwave and fridge. Each holiday home features a private bathroom. Bardonecchia is 48 km from Gîtes La Source. Apartment Réotier : Address : HAMEAU DE CHAUVET 05600 Chauvet Distance on map, Hotel - Réotier : 3.04 kilometers Number of room : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Camping Saint James Guest accommodation Guillestre Camping Saint James offers self-catering accommodation set in a wood just a 1 km from Queyras Natural Regional Park and 18 km from Serre Ponçon lake. It features a playground area for children and free, private parking on site. All mobile homes and chalets have a garden and a private terrace. Each has a living area with an equipped kitchenette including a coffee machine, a stove and a microwave or an oven. There is also a private bathroom with a bath or shower. WiFi access is available in all rooms at an extra cost. In summer, an area reserved for ball games is provided, and entertainment staff are on site. Hiking trips can be organised, amongst other activities such as canyoning, rafting and rock-climbing. You will find a supermarket and restaurant just 1 km away, and Guillestre Train Station is 3 km away. Price : from 90.00 € to 93.00 € Guest accommodation Réotier : Location : D902a route des campings 05600 Guillestre Route on map, Hotel - Réotier : 3.36 kilometer Number of rooms : 10 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- La Rochette Guest accommodation Guillestre Situated in Guillestre, La Rochette provides accommodation with free WiFi and seating area. The units provide views of the mountain and come with a washing machine, a fully equipped kitchenette, and a shared bathroom with free toiletries and a hair dryer. An oven and microwave are also available, as well as a coffee machine. A continental breakfast is served each morning at the property. The campsite offers a terrace. Guests can relax in the garden at the property. Sestriere is 38 km from La Rochette. Guest accommodation Réotier : Address : route des campings 05600 Guillestre Distance on map between hotel and center of Réotier : 3.68 km Room in hotel : 7 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Villaret Apartment Risoul Apartment Villaret is set in Risoul, 3.2 km from Tk Orée du Bois. Risoul 1850 Ski School is 3.3 km away. The accommodation features a TV. There is also a kitchen, equipped with a dishwasher. Every unit is fitted with a private bathroom with a bath and free toiletries. TS Mélezets is 3.4 km from Apartment Villaret, while TK Melezet 1 is 3.4 km from the property. Apartment Réotier : Location : VILLARET I Appartement N°116 05600 Risoul Distance between hotel and center of Réotier : 3.82 kms Rooms in hotel : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Villaret Apartment Risoul Apartment Villaret is an apartment situated in Risoul, 3.2 km from Tk Orée du Bois. The unit is 3.3 km from Risoul 1850 Ski School. The kitchen is fitted with an oven. A TV is featured. There is a private bathroom with a bath. TS Mélezets is 3.4 km from Apartment Villaret, while TK Melezet 1 is 3.4 km away. Apartment Réotier : Address : VILLARET II Apparetement n°31 05600 Risoul Distance on map, Hotel - Réotier : 3.82 kilometers Number of room : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Villaret Apartment Risoul Set in Risoul, Apartment Villaret is 3.2 km from Tk Orée du Bois. Risoul 1850 Ski School is 3.3 km from the property. The accommodation is fitted with a TV. There is also a kitchen, fitted with an oven. Every unit features a private bathroom with a bath. TS Mélezets is 3.4 km from Apartment Villaret, while TK Melezet 1 is 3.4 km away. Apartment Réotier : Location : VILLARET II 05600 Risoul Route on map, Hotel - Réotier : 3.82 kilometer Number of rooms : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Villaret Apartment Risoul Apartment Villaret is situated in Risoul, 3.2 km from Tk Orée du Bois. Risoul 1850 Ski School is 3.3 km from the property. The accommodation is fitted with a TV. All units feature a kitchen equipped with a microwave and fridge. There is a private bathroom with a bath in every unit. TS Mélezets is 3.4 km from Apartment Villaret. Apartment Réotier : Address : VILLARET I 05600 Risoul Distance on map between hotel and center of Réotier : 3.82 km Room in hotel : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Villaret Apartment Risoul Set 3.2 km from Tk Orée du Bois and 3.3 km from Risoul 1850 Ski School, Apartment Villaret offers accommodation in Risoul. The apartment is 3.4 km from TS Mélezets. The kitchen comes with an oven and a microwave. A TV is provided. There is a private bathroom with a bath. TK Melezet 1 is 3.4 km from Apartment Villaret, while TS Cézier is 3.4 km away. Apartment Réotier : Location : VILLARET II RISOUL1850 05600 Risoul Distance between hotel and center of Réotier : 3.82 kms Rooms in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- La Bonne Auberge Hotel Risoul Overlooking the Ecrins mountain range, La Bonne Auberge is located in the Queyras Valley, 15 minutes from the Risoul ski station. It offers a seasonal outdoor swimming pool and spacious rooms with private bathrooms. La Bonne Auberge has its own restaurant, which serves regional cuisine made from fresh local produce. Meals can be enjoyed on the outdoor terrace. During winter a free shuttle service is available 200 metres from the property and can take you to the ski slopes. Additional facilities include a playground, a library, a games room with pool table and free-use bicycles. In the surrounding area of La Bonne Auberge, guests can enjoy canyoning, rafting, mountain biking and hiking. Prices : from 65.00 € to 100.00 € Hotel Réotier : Address : La Rua 05600 Risoul Distance on map, Hotel - Réotier : 4.00 kilometers Number of room : 25 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- L'Horizon Apartment Risoul L'Horizon is located in Risoul, 9 km from Cretes, 9 km from TS Mélezet, as well as 9 km from TK Melezet 1. The apartment is 9 km from TS Césier. Situated on the ground floor, this apartment is fitted with with 1 bedroom, a well-equipped kitchen, a living room, and a flat-screen TV. Clos Fournier is 9 km from L'Horizon. Rate : from 80.00 € Apartment Réotier : Location : appartement n°1 résidence l'Horizon Gaudissard Bas 05600 Risoul Route on map, Hotel - Réotier : 4.02 kilometer Number of rooms : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Alpineaccomodation Apartment Guillestre Featuring free WiFi throughout the property, Alpineaccomodation is located in Guillestre, 35 km from Briançon, and offers mountain views. Free private parking is available on site. The accommodation features a seating area. Some units include a balcony and/or patio. There is also a kitchen, equipped with a dishwasher, oven and fridge. A stovetop and coffee machine are also featured. Each unit is fitted with a private bathroom with a shower. A selection of activities are offered in the area, such as cycling, skiing, horse riding, climbing and mountaineering. Vars is 15 km away, while Les Orres is 32 km from the property. Serre Chevalier is 49 km from the property. Apartment Réotier : Address : rue auguste chastan 16 05600 Guillestre Distance on map between hotel and center of Réotier : 4.06 km Room in hotel : 4 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Le serre de chanteloube Apartment Saint-Crépin Apartment Le serre de chanteloube is set in Saint-Crépin and offers barbecue facilities. The property has garden views and is 24 km from Vars. This apartment comes with a kitchen, a seating area, and a satellite TV. Briançon is 28 km from the apartment, while Risoul is 11 km from the property. Prices : from 324.88 € Apartment Réotier : Location : Le serre de chanteloube 05600 Saint-Crépin Distance between hotel and center of Réotier : 4.06 kms Rooms in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- B&B et Apartments Moulin du Martinet Bed and Breakfast Guillestre Situated in Guillestre, B&B et Apartments Moulin du Martinet offers accommodation with free WiFi and flat-screen TV, as well as a garden. Each unit comes with a microwave, toaster, a coffee machine, as well as a fridge and kettle. There is also a kitchen in some of the units equipped with a dishwasher. A continental breakfast is served daily at the property. The bed and breakfast offers a terrace. A a ski pass sales point is available on site and skiing can be enjoyed within close proximity of B&B et Apartments Moulin du Martinet. Vars is 15 km from the accommodation, while Briançon is 34 km away. Rate : from 70.00 € to 80.00 € Bed and Breakfast Réotier : Address : 2 Chemin du moulin blanc 05600 Guillestre Distance on map, Hotel - Réotier : 4.07 kilometers Number of room : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Florins Apartment Risoul Located in Risoul, Apartment Florins is 3.1 km from Tk Orée du Bois. Risoul 1850 Ski School is 3.2 km away. The accommodation is fitted with a TV. There is also a kitchen, equipped with a dishwasher. There is a private bathroom with free toiletries in every unit. TS Cézier is 3.3 km from Apartment Florins, while TS Mélezets is 3.4 km from the property. Apartment Réotier : Location : FLORINS I 05600 Risoul Route on map, Hotel - Réotier : 4.09 kilometer Number of rooms : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Clématites Apartment Risoul Apartment Clématites offers accommodation in Risoul. Tk Orée du Bois is 3.1 km away. The accommodation comes with a TV. There is also a kitchen, equipped with a dishwasher. There is a private bathroom with a bath in every unit. Risoul 1850 Ski School is 3.2 km from Apartment Clématites, while TS Cézier is 3.3 km from the property. Apartment Réotier : Address : CLEMATITES C 05600 Risoul Distance on map between hotel and center of Réotier : 4.09 km Room in hotel : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Florins Apartment Risoul Apartment Florins offers accommodation in Risoul, 3.1 km from Tk Orée du Bois. The unit is 3.2 km from Risoul 1850 Ski School. The kitchen has an oven. A TV is featured. There is a private bathroom with a bath. TS Cézier is 3.3 km from Apartment Florins, while TS Mélezets is 3.4 km from the property. Apartment Réotier : Location : FLORINS II Appartement N° 45 05600 Risoul Distance between hotel and center of Réotier : 4.09 kms Rooms in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Florins Apartment Risoul Apartment Florins is an apartment set in Risoul, 3.1 km from Tk Orée du Bois. The unit is 3.2 km from Risoul 1850 Ski School. The unit is fitted with a kitchen. TS Cézier is 3.3 km from Apartment Florins, while TS Mélezets is 3.4 km from the property. Apartment Réotier : Address : FLORINS II Appartement N°12 05600 Risoul Distance on map, Hotel - Réotier : 4.09 kilometers Number of room : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Florins Apartment Risoul Apartment Florins is an apartment located in Risoul, 3.1 km from Tk Orée du Bois. Guests benefit from balcony. The kitchen is fitted with a dishwasher and an oven and there is a private bathroom. A TV is provided. Risoul 1850 Ski School is 3.2 km from Apartment Florins, while TS Cézier is 3.3 km from the property. Apartment Réotier : Location : FLORINS II Appartement N°53 05600 Risoul Route on map, Hotel - Réotier : 4.09 kilometer Number of rooms : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Florins Apartment Risoul Set 3.1 km from Tk Orée du Bois and 3.2 km from Risoul 1850 Ski School, Apartment Florins features accommodation in Risoul. All units are equipped with a TV and a fully equipped kitchen with a dishwasher. TS Cézier is 3.3 km from the apartment. The nearest airport is Barcelonnette - Saint-Pons Airport, 29 km from the property. Apartment Réotier : Address : FLORINS I 05600 Risoul Distance on map between hotel and center of Réotier : 4.09 km Room in hotel : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Route du Villard Apartment Saint-Crépin Offering free WiFi and garden views, Apartment Route du Villard is an accommodation set in Saint-Crépin. Guests staying at this apartment have access to a fully equipped kitchen. The apartment includes 1 bedroom and a living room with a TV and a DVD player. The apartment offers a barbecue. Vars is 24 km from Apartment Route du Villard. Price : from 362.87 € Apartment Réotier : Location : Route du Villard 05600 Saint-Crépin Distance between hotel and center of Réotier : 4.09 kms Rooms in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Chalet La Rua Guest accommodation Risoul Chalet La Rua is situated in the Risoul Village district of Risoul, 12 km from Cretes, 12 km from TS Mélezet and 12 km from TK Melezet 1. The TS Clos du Vallon is within 12 km of the chalet. This chalet is equipped with 3 bedrooms, a living room and a fully equipped kitchen. A TV and DVD player are featured. The chalet offers a barbecue. TS Césier is 12 km from Chalet La Rua, while Clos Fournier is 12 km away. Prices : from 605.22 € Guest accommodation Réotier : Address : 5 La Rua 05600 Risoul Distance on map, Hotel - Réotier : 4.11 kilometers Number of room : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Cimbro Apartment Risoul Set in Risoul, Apartment Cimbro is 2.8 km from Tk Orée du Bois. Risoul 1850 Ski School is 2.9 km from the property. All units feature a TV. There is also a kitchen, fitted with a dishwasher. Each unit is fitted with a private bathroom with free toiletries. TS Cézier is 3 km from Apartment Cimbro. Apartment Réotier : Location : CIMBRO II 05600 Risoul Route on map, Hotel - Réotier : 4.14 kilometer Number of rooms : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Soldanelles Apartment Risoul Set in Risoul, this apartment is 2.8 km from Tk Orée du Bois. Guests benefit from balcony. The unit is equipped with a kitchen. A TV is featured. There is a private bathroom with a bath. Risoul 1850 Ski School is 2.9 km from Apartment Soldanelles, while TS Cézier is 3 km away. Apartment Réotier : Address : SOLDANELLES Appartement N°43 05600 Risoul Distance on map between hotel and center of Réotier : 4.14 km Room in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Clarines Apartment Risoul Apartment Clarines offers accommodation in Risoul. The apartment is 2.8 km from Tk Orée du Bois. The kitchen comes with a microwave and there is a private bathroom. A TV is available. Risoul 1850 Ski School is 2.9 km from Apartment Clarines, while TS Cézier is 3 km from the property. Apartment Réotier : Location : CLARINES B2 Appartement 335 05600 Risoul Distance between hotel and center of Réotier : 4.14 kms Rooms in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Diamant Apartment Risoul Located 2.8 km from Tk Orée du Bois, Apartment Diamant offers accommodation in Risoul. The apartment is 2.9 km from Risoul 1850 Ski School. The kitchen is fitted with a dishwasher and a microwave and there is a private bathroom. A TV is provided. TS Cézier is 3 km from Apartment Diamant, while TS Mélezets is 3.1 km away. Apartment Réotier : Address : DIAMANT C Appartement 71 05600 Risoul Distance on map, Hotel - Réotier : 4.14 kilometers Number of room : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Pégase Apartment Risoul Apartment Pégase is set in Risoul, 2.8 km from Tk Orée du Bois. Risoul 1850 Ski School is 2.9 km away. All units feature a TV. All units have a kitchen fitted with a dishwasher and oven. Every unit is fitted with a private bathroom with free toiletries. TS Cézier is 3 km from Apartment Pégase, while TS Mélezets is 3.1 km from the property. Apartment Réotier : Location : PEGASE 60 05600 Risoul Route on map, Hotel - Réotier : 4.14 kilometer Number of rooms : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Cimbro 1 Apartment Risoul Set within 2.8 km of Tk Orée du Bois and 2.9 km of Risoul 1850 Ski School in Risoul, Apartment Cimbro 1 offers accommodation with a kitchen. Fitted with a balcony, the units feature a TV and a private bathroom with bath. TS Cézier is 3 km from the apartment, while TS Mélezets is 3.1 km from the property. The nearest airport is Barcelonnette - Saint-Pons Airport, 29 km from the property. Apartment Réotier : Address : CIMBRO II 05600 Risoul Distance on map between hotel and center of Réotier : 4.14 km Room in hotel : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Chamois 1 Apartment Risoul Set 2.8 km from Tk Orée du Bois and 2.9 km from Risoul 1850 Ski School, Apartment Chamois 1 features accommodation situated in Risoul. Guests staying at this apartment have access to a balcony. The apartment boasts a TV, a well-equipped kitchen with an oven and a microwave, and a bathroom with a bath. TS Cézier is 3 km from Apartment Chamois 1. The nearest airport is Barcelonnette - Saint-Pons Airport, 29 km from the property. Apartment Réotier : Location : CHAMOIS 05600 Risoul Distance between hotel and center of Réotier : 4.14 kms Rooms in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Clarines Apartment Risoul Apartment Clarines offers accommodation in Risoul, 2.8 km from Tk Orée du Bois and 2.9 km from Risoul 1850 Ski School. The unit is 3 km from TS Cézier. A dishwasher, an oven and a microwave can be found in the kitchen. A TV is provided. There is a private bathroom with a bath. TS Mélezets is 3.1 km from Apartment Clarines, while TK Melezet 1 is 3.1 km away. Apartment Réotier : Address : CLARINES B2 05600 Risoul Distance on map, Hotel - Réotier : 4.14 kilometers Number of room : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Diamant Apartment Risoul Located 2.8 km from Tk Orée du Bois and 2.9 km from Risoul 1850 Ski School, Apartment Diamant offers accommodation in Risoul. The unit is 3 km from TS Cézier. The kitchen features an oven and there is a private bathroom. A TV is offered. TS Mélezets is 3.1 km from Apartment Diamant, while TK Melezet 1 is 3.1 km from the property. Apartment Réotier : Location : DIAMANT C Appartement 73 05600 Risoul Route on map, Hotel - Réotier : 4.14 kilometer Number of rooms : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Edelweiss Apartment Risoul Located 2.8 km from Tk Orée du Bois, Apartment Edelweiss offers accommodation in Risoul. The unit is 2.9 km from Risoul 1850 Ski School. The kitchen has an oven. A TV is available. There is a private bathroom with a bath. TS Cézier is 3 km from Apartment Edelweiss, while TS Mélezets is 3.1 km from the property. Apartment Réotier : Address : EDELWEISS B Centre station 05600 Risoul Distance on map between hotel and center of Réotier : 4.14 km Room in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Hotel Restaurant Les Barnieres Hotel Guillestre Located 500 metres from the centre of Guillestre, Hotel Restaurant Les Barnieres offers an outdoor swimming pool, a tennis court, a tennis table and a terrace with panoramic mountain views. It also features a bar and an on-site restaurant. All of the rooms at Hotel Restaurant Les Barnieres have wooden furniture, mountain views and a flat-screen TV. Each room also includes a private bathroom with a bath. A buffet breakfast with hot drinks, jams, ham and cereals is served daily in the communal lounge. The hotel’s restaurant offers traditional dishes from the region for lunch and dinner. Free Wi-Fi is provided in public areas, at Hotel Restaurant Les Barnieres. Free private parking is possible on site and the Lake Serre-Ponçon is 18 km from the hotel. Several activities are available in summer, such as rafting, climbing, horse riding and hiking, and Vars Ski Resort is 15 km away. Hotel Réotier : Location : Les Barnieres 05600 Guillestre Distance between hotel and center of Réotier : 4.14 kms Rooms in hotel : 32 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Altair Apartment Risoul Situated in Risoul, Apartment Altair is 2.8 km from Tk Orée du Bois. Risoul 1850 Ski School is 2.9 km from the property. The accommodation features a TV. There is also a kitchen, equipped with a dishwasher. Every unit is fitted with a private bathroom with free toiletries. TS Cézier is 3 km from Apartment Altair, while TS Mélezets is 3.1 km away. Apartment Réotier : Address : ALTAIR 05600 Risoul Distance on map, Hotel - Réotier : 4.14 kilometers Number of room : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Cristal Apartment Risoul Apartment Réotier : Location : CRISTAL A 05600 Risoul Route on map, Hotel - Réotier : 4.14 kilometer Number of rooms : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Christiana Apartment Risoul Apartment Christiana offers accommodation in Risoul, 2.8 km from Tk Orée du Bois. The unit is 2.9 km from Risoul 1850 Ski School. The kitchen is fitted with a dishwasher and a microwave and there is a private bathroom. A TV is provided. TS Cézier is 3 km from Apartment Christiana, while TS Mélezets is 3.1 km away. Apartment Réotier : Address : CHRISTIANIA C 05600 Risoul Distance on map between hotel and center of Réotier : 4.14 km Room in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Airelles Apartment Risoul Situated in Risoul, Apartment Airelles is 2.8 km from Tk Orée du Bois. Risoul 1850 Ski School is 2.9 km from the property. The accommodation comes with a TV. There is also a kitchen, equipped with a dishwasher and microwave. Every unit has a private bathroom with a bath and free toiletries. TS Cézier is 3 km from Apartment Airelles, while TS Mélezets is 3.1 km away. Apartment Réotier : Location : AIRELLES A Centre station 05600 Risoul Distance between hotel and center of Réotier : 4.14 kms Rooms in hotel : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Chabrières Apartment Risoul Set in Risoul, Apartment Chabrières is 2.8 km from Tk Orée du Bois. Risoul 1850 Ski School is 2.9 km from the property. All units have a TV. All units include a kitchen equipped with a dishwasher and oven. There is a private bathroom with free toiletries in each unit. TS Cézier is 3 km from Apartment Chabrières. Apartment Réotier : Address : CHABRIERES II Appartement N° 66 05600 Risoul Distance on map, Hotel - Réotier : 4.14 kilometers Number of room : 2 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Clématites Apartment Risoul Set in Risoul, this apartment is 2.8 km from Tk Orée du Bois. The apartment is 2.9 km from Risoul 1850 Ski School. The kitchen is fitted with an oven. A TV is featured. There is a private bathroom with a bath. TS Cézier is 3 km from Apartment Clématites, while TS Mélezets is 3.1 km away. Apartment Réotier : Location : CLEMATITES A Appartement 34 05600 Risoul Route on map, Hotel - Réotier : 4.14 kilometer Number of rooms : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Chabrières 3 Apartment Risoul Located in Risoul in the Provence-Alpes-Côte d'Azur region, Apartment Chabrières 3 is an apartment featuring a balcony. The accommodation is 2.8 km from the Tk Orée du Bois. The apartment has a TV. The kitchen is equipped with an oven and a microwave and there is a bathroom. Risoul 1850 Ski School is 2.9 km from the apartment, while TS Cézier is 3 km from the property. The nearest airport is Barcelonnette - Saint-Pons Airport, 29 km from Apartment Chabrières 3. Apartment Réotier : Address : CHABRIERES I 05600 Risoul Distance on map between hotel and center of Réotier : 4.14 km Room in hotel : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Edelweiss Apartment Risoul Situated in Risoul, Apartment Edelweiss is 2.8 km from Tk Orée du Bois. Risoul 1850 Ski School is 2.9 km away. All units feature a TV. There is also a kitchen, equipped with a dishwasher and microwave. There is a private bathroom with a bath and free toiletries in each unit. TS Cézier is 3 km from Apartment Edelweiss, while TS Mélezets is 3.1 km from the property. Apartment Réotier : Location : EDELWEISS B Appartement N° 35 05600 Risoul Distance between hotel and center of Réotier : 4.14 kms Rooms in hotel : 3 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Cristal Apartment Risoul Apartment Cristal is an apartment set in Risoul, 2.8 km from Tk Orée du Bois. Guests benefit from balcony. The unit is fitted with a kitchen. A TV is available. There is a private bathroom with a bath. Risoul 1850 Ski School is 2.9 km from Apartment Cristal, while TS Cézier is 3 km away. Apartment Réotier : Address : CRISTAL B 05600 Risoul Distance on map, Hotel - Réotier : 4.14 kilometers Number of room : 1 Book now -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Apartment Soldanelles Apartment Risoul Apartment Soldanelles is an apartment set in Risoul, 2.8 km from Tk Orée du Bois. The unit is 2.9 km from Risoul 1850 Ski School. An oven and a fridge can be found in the kitchen and there is a private bathroom. A TV is featured. TS Cézier is 3 km from Apartment Soldanelles, while TS Mélezets is 3.1 km away. Apartment Réotier : Location : SOLDANELLES Appartement N°36 05600 Risoul Route on map, Hotel - Réotier : 4.14 kilometer Number of rooms : 1 Book now Réotier hotels map Below here is the hotels map of Réotier. Names and details of Réotier hotels can be shown on the map clicking on the prices icons. Others hotels, maps, and towns in france Find another hotel, town, zip code, department, region, ... Quick links Réotier : Réotier Hotel Réotier Réotier hotels map Road map Réotier Map Réotier Photos Réotier Weather Réotier Population Réotier Housing Réotier Make a link to this page of Réotier with the following code : Map of France | Regions | Departments | Cities | Partners | Terms | Contact
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Search Results - NHS Lgbt Carers Forum;LHH;Lifecentre;Limbless Association;Listening Books;Little Hearts Matter;Local Government Ombudsman;LOOK (National Office);Lupus Uk;Macintyre Results for Carer centres and services in Buckland Filleigh Showing 181-190 of 374 results Please check travel times before starting your journey.Distances are given in a straight line and may not be the quickest to travel to Local National Carer-centres-and-services details Address & contact details Information supplied by Target group Lgbt Carers Forum Address & contact detailsTel: 0845 330 3030This is a premium number which will be charged at a higher rate. The service provider has not yet provided details about the service chargeEmail: [email protected]: support.lgf.org.uk/ Information supplied by An online and in person support group for LGB&T carers and professionals across the UK but with particular focus on the North West of England. Target group n/a Data not available LHH Address & contact detailsTel: 01444 236099Email: [email protected]: lhh.org.uk/ Information supplied by For people who are in financial need due to illness or disability. One-off grants and regular quarterly grants available. One-off grants are typically for essential household items and specialist equipment not available through statutory services; maximum £250. Carer's breaks when funds allow. Target group n/a Data not available Lifecentre Address & contact detailsTel: 01243 786349Email: [email protected]: www.lifecentre.uk.com Information supplied by Lifecentre is a registered charity (Reg charity No. 1127779) which offers face to face counselling for survivors of sexual abuse in West Sussex, both adults and children. We also provide telephone, text and email helpline services which are available nationally. Target group Survivors of sexual abuse and their supporters Limbless Association Address & contact detailsTel: 0800 644 0185 / 01277 402331Email: [email protected]: limbless-association.org/ Information supplied by The Limbless Association provides information and support to the limb-loss community. We aim to support people of all ages and backgrounds through a variety of existing programs and services. Target group Anyone affected by limb-loss Listening Books Address & contact detailsTel: 020 7407 9417Email: [email protected]: www.listening-books.org.uk Information supplied by We are a UK charity providing a fantastic selection of high-quality audiobooks to over 100,000 people across the UK, who are unable to read or hold a book due to illness, disability, learning difficulties or mental health conditions. We send our audiobooks through the post on MP3 CD, or they can ... Continue reading overview Target group Anyone who finds it difficult to read due to an illness or disability Little Hearts Matter Address & contact detailsTel: 0121 455 8982Email: [email protected]: www.lhm.org.uk/ Information supplied by Little Hearts Matter offers support and information to families with children affected by heart conditions such as Hypoplastic Left Heart Syndrome (HLHS), Pulmonary Atresia, Tricuspid Atresia or Double Inlet Ventricle. Target group Families, medical professionals, teachers, carers and anyone affected by a single ventricle condition. Local Government Ombudsman Address & contact detailsTel: 0300 061 0614Email: [email protected]: www.lgo.org.uk/ Information supplied by The Local Government Ombudsman looks into complaints about most council functions and those of some other authorities, including complaints about privately arranged adult social care. The Ombudsman only covers authorities in England. You need to complain to the council or care provider first, b... Continue reading overview Target group General public LOOK (National Office) Address & contact detailsTel: 07464 351958Email: [email protected]: www.look-uk.org Information supplied by When you first find out your child has a serious sight problem there'll be a million questions you'll want to ask, but finding answers from the professionals is difficult or sometimes impossible - especially when you're feeling vulnerable and isolated. Our mission is to improve the lives of fami... Continue reading overview Target group Families with Visually Impaired children Lupus Uk Address & contact detailsTel: 01708 731251Email: [email protected]: www.lupusuk.org.uk Information supplied by LUPUS UK is the only national registered charity supporting people with systemic lupus and discoid lupus and assisting those approaching diagnosis. We presently have over 6000 Members and a number of Regional Groups around the UK who arrange medical talks, publish local newsletters, set up loca... Continue reading overview Target group Anyone Macintyre Address & contact detailsTel: 01908 230100Email: [email protected]: www.macintyrecharity.org Information supplied by We provide learning, support and care for more than 1000 children, young people and adults with learning disabilities and/or autism across England and Wales. Our range of provision includes registered care homes, supported living schemes, accredited training schemes and lifelong learning service... Continue reading overview Target group Children, young people and adults with learning disabilities and/or autism
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Vaccines | Free Full-Text | Public Perceptions of Harms and Benefit of COVID-19 Immunity Certificate: A Cross-Sectional Study in the Italian Setting A cross-sectional survey between 29 January 2022 and 3 February 2022 was conducted to understand the public rationale for accepting or rejecting the use of COVID-19 immunity certificates and to identify the psychosocial factors that mostly predict the positive/negative individuals& rsquo; perceptions of this measure. One thousand twenty-two Italian adults were recruited by a professional panel provider by employing a stratified sampling strategy controlled for gender, age, geographical area of residence, size of the urban centre of residence, employment, and wage. Eight Welch& rsquo;s ANOVAs were then carried out to compare the perception of benefits and the perception of harms among different population groups. Multiple linear regression was carried out to measure the explained variance of benefits perception and harms perception by age, trust in institutions, and concern for health emergencies. The results shows that age, trust in institution, and concern for the COVID-19 emergency explain more variance of perceived benefits than of perceived harms of COVID-19 immunity certificates but the opposite regarding political orientation which explains perceived harms better than perceived benefits. The need for policy improvements is pressing because a large share of the world& rsquo;s population remains unvaccinated. Moreover, our results can serve as vital information for similar health crises that may occur in the future. In addition, our results are expected to offer useful insights into public feelings around the use of digital health information tools. Public Perceptions of Harms and Benefit of COVID-19 Immunity Certificate: A Cross-Sectional Study in the Italian Setting Lorenzo Palamenghi 2,3,5 , Marta Acampora 2,3 and Guendalina Graffigna 2,3,5 1 Faculty of Psychology, Università Cattolica del Sacro Cuore, L.go Gemelli 1, 20123 Milan, Italy 2 Department of Psychology, Università Cattolica del Sacro Cuore, L.go Gemelli 1, 20123 Milan, Italy 3 EngageMinds HUB—Consumer, Food & Health Engagement Research Center, Università Cattolica del Sacro Cuore, 20123 Milan, Italy 4 EngageMinds HUB—Consumer, Food & Health Engagement Research Center, 26100 Cremona, Italy 5 Faculty of Agriculture, Food and Environmental Sciences, Università Cattolica del Sacro Cuore, Via Bissolati, 74, 26100 Cremona, Italy * Author to whom correspondence should be addressed. Vaccines 2022 , 10 (9), 1501; https://doi.org/10.3390/vaccines10091501 Received: 20 July 2022 / Revised: 29 August 2022 / Accepted: 6 September 2022 / Published: 8 September 2022 (This article belongs to the Special Issue Vaccination Hesitancy: Attitudes and Associated Factors ) Versions Notes Article Views Abstract A cross-sectional survey between 29 January 2022 and 3 February 2022 was conducted to understand the public rationale for accepting or rejecting the use of COVID-19 immunity certificates and to identify the psychosocial factors that mostly predict the positive/negative individuals’ perceptions of this measure. One thousand twenty-two Italian adults were recruited by a professional panel provider by employing a stratified sampling strategy controlled for gender, age, geographical area of residence, size of the urban centre of residence, employment, and wage. Eight Welch’s ANOVAs were then carried out to compare the perception of benefits and the perception of harms among different population groups. Multiple linear regression was carried out to measure the explained variance of benefits perception and harms perception by age, trust in institutions, and concern for health emergencies. The results shows that age, trust in institution, and concern for the COVID-19 emergency explain more variance of perceived benefits than of perceived harms of COVID-19 immunity certificates but the opposite regarding political orientation which explains perceived harms better than perceived benefits. The need for policy improvements is pressing because a large share of the world’s population remains unvaccinated. Moreover, our results can serve as vital information for similar health crises that may occur in the future. In addition, our results are expected to offer useful insights into public feelings around the use of digital health information tools. Keywords: health certificate ; immunity passports ; immunity certification ; public responses ; health policy ; consumer psychology 1. Introduction The global COVID-19 pandemic hit the world in early 2020. This led to worldwide restrictions on social life and freedom of traveling, while also damaging the global economy. In response to the widespread impact of the COVID-19 pandemic, countries across the world have proposed and implemented health certification policies (the so-called COVID-19 immunity certificates) that allow waivers on several restrictions (e.g., ability to travel, ability to access social venues, etc.) based on individuals’ infection/vaccination status or potential immunity. The purpose of such certifications was twofold: to restrict the access to social venues and high-risk situations (such as going to a restaurant or boarding an airplane) only to those individuals with a likely immunity to the virus and to promote the vaccination as well by giving an incentive to immunized persons. Most discussions around immunity- or infection-based documentation policies have focused on scientific plausibility, economic benefit, and challenges relating to ethics and equity. As COVID-19 vaccines are rolled out, attention has turned to confirmation of immunity and how documentation such as immunity passports can be implemented. However, the socio-cultural variability interacting with the implementation of COVID-19-related policies may hinder a one-size-fits-all approach [ 1 ]. Social science literature on policy implementation, discussing how health policies and guidelines unfold and are carried out in practice, highlights that this is not a straightforward undertaking that happens the same way everywhere for everyone [ 2 , 3 ]. Indeed, a relevant consideration for governments in deciding how to intervene to change people’s behavior is the attitude of the public towards such interventions and the extent to which any interventions are likely to be deemed as acceptable. This matters not only because levels of acceptability may critically affect the effectiveness of the health policy measure but also because accountable governments need to be aware of public attitudes if they want to act in a way that takes into consideration the population’s doubts and feelings. Indeed, the public following or adhering to health policies or guidelines does not imply an automatic process of acceptance; on the contrary, according to other studies in this field, people’s adoption of public health measures is intertwined with individuals’ characteristics—such as socio-demographics [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ], COVID-19-related health status [ 6 , 8 ], attitudes towards vaccination [ 12 ], political orientation [ 4 , 6 , 13 ], health risk perception [ 7 ], and trust in institutions [ 8 , 14 ]—and attitudes towards such mandates in terms of potential perceived benefits or harms that they may provide them. Previous studies on the public perception of COVID-19 immunity certifications [ 4 , 9 , 14 , 15 , 16 ] showed that reasons in favor of this measure were related to some individual and collective perceived benefits they could provide (i.e., infection reduction, vulnerable people’s health protection, safer access to public venues, public health safeguarding, and economy protection) [ 4 , 8 , 13 , 15 , 16 ]. On the other hand, research also showed some perceived harms and concerns related to this measure (i.e., privacy and freedom violation and inequality increase) [ 4 , 9 , 15 , 16 ]. Based on these premises, this study aimed at investigating the citizens’ reasons for accepting or rejecting the use of COVID-19 immunity certificates and at identifying the psychosocial factors that most predict the positive/negative individuals’ perceptions of this measure. 2. Materials and Methods 2.1. Sample and Procedure One thousand twenty-two Italian adults aged between 20 and 72 years old were recruited by a professional panel provider (Norstat Italia srl) by employing a stratified sampling strategy controlled for gender, age, geographical area of residence, size of the urban centre of the residence, employment, and wage. After providing their informed consent, the participants were asked to fill out an online survey (using a CAWI methodology); this study is part of a broader project (“Italian Citizens’ Food Habits Monitoring from a Consumer Psychology Perspective) aimed at monitoring Italian citizens’ habits. The study was designed as a cross-sectional survey, and data were collected between 29 January 2022 and 3 February 2022. At the time of data collection, in Italy, it was mandatory to show COVID-19 immunity certificates to join almost all social activities, including going to work, going to a bar or a restaurant, traveling by public transportation, and many others. 2.2. Measures The participants were asked questions regarding: Socio-demographic questions such as gender, age, monthly family wage, and level of education. Education was recorded in 3 categories (1 = middle school or lower, 2 = secondary school, and 3 = degree or more); One question about whether they have ever contracted COVID-19 or not (proved by test); One question regarding their political orientation on a scale from 1 (far left-wing) to 10 (far right-wing) plus the option “I don’t take a position, I don’t care”. Answers were then recoded it into 4 categories (“left-wing”, “right-wing”, “center”, and no “political orientation”); One question assessing their level of trust in institutions on a 5-step Likert-type scale, where higher numbers corresponded to higher levels of trust; A question assessing their level of concern about the health emergency by asking them to indicate how concerned they are about the emergency from COVID-19 on a scale of 1 to 10; One question assessing their level of confidence about the effectiveness of vaccines in preventing infectious diseases; Eleven questions regarding their opinions on the COVID-19 immunity certificate policy measure, which stressed both potential benefits (7 items) and harms of this certification (4 items). Opinions were assessed on a 5-step Likert-type scale, where higher numbers corresponded to higher levels of agreement. Items were assigned to benefits or to harms according to whether they investigate the limitations or the advantages in a similar way to Lewandowsky [ 8 ]. The whole survey administered to participants is reported in Appendix A . 2.3. Analyses One index of perceived benefits and one index of perceived harms of COVID-19 immunity certificates was made by calculating the mean of the answers to the relative items. Then, Cronbach’s Alpha was calculated to test the internal consistency of the two indices, and we considered a good value if >0.60 [ 17 ]. Univariate outlier detection was then carried out with the MAD function [ 18 , 19 ], checking the z-scores, and displaying the data with boxplots (available in the Appendix B ). After testing the assumptions of normality with the Shapiro–Wilk test and the QQ-plot and the homoscedasticity with Levene’s Test, eight Welch’s ANOVAs [ 20 ] were then carried out to compare the perception of benefits and the perception of harms amongst males and females, those who had COVID-19 and those who had not, three groups with different education levels, and four groups with different political orientation. Then, Games–Howell post-hoc tests were run where relevant. The Eta-Squared index (η 2 ) was calculated for each of the Welch’s ANOVAs to measure the effect size, considering values as recommended by Cohen [ 21 ]. Finally, two multiple linear regressions with the entering method were carried out to measure the explained variance of benefits perception and harms perception by the age, the trust in the institution, the concern for health emergencies, and the confidence level in effectiveness of vaccines to prevent infective disease. Residuals vs. fitted and residuals vs. leverage plots were made for diagnostic analysis and can be viewed in the Appendix C . All the analyses were carried out using R in the R Studio environment; the script can be found in the attached material. Some minor variables required recodification and labelling with SPSS software (IBM SPSS Statistics 27.0.1.0, Armonk, New York, NY USA). 3. Results 3.1. Descriptive Statistics Overall, the sample included 1022 Italian citizens (50.7% female) aged between 18 and 70 years old (mean 46.9 with a standard deviation of 13.8). Table 1 shows the socio-demographic characteristics of the whole sample. Table 1. Sample characteristics. Cronbach’s α for the seven items related to the potential benefits of COVID-19 immunity certificates was 0.956, while for the four items related to the potential harms of COVID-19 immunity certificates was 0.902; items and their descriptive statistics are displayed in Table 2 . No outliers were detected with z-scores; a few were found by displaying the data with boxplots—available in Appendix B —in the case of the variable “confidence level in vaccine efficacy”, and also a few in the case of the variable “concern for the COVID-19 emergency” were found using the MAD function [ 18 , 19 ]. Since none of these outliers were consistent in more than one of these three methods, we decided to not remove any of them. Table 2. Survey items assessing perceived harms and benefits of the immunity certification implementation. 3.2. Difference between Groups All diagnostic plots show no issues with the regression models, so we have proceeded to the results’ production and interpretation. Independence of the observations was guaranteed by the panel provider, while the homoscedasticity was violated just in two cases out of eight, i.e., benefits perception of COVID-19 immunity certificates on political groups and harms perception of COVID-19 immunity certificates on gender, and for this reason, Welch’s test was chosen instead of the standard ANOVA test. On the other hand, the Shapiro–Wilk test and the QQ-plots show that normality was violated in each of the eight cases; nevertheless, we considered this violation as not a serious threat to the reliability of our results because of ANOVA’s robustness to the violation of this assumption [ 22 , 23 , 24 ] and in light of a comparison showing no difference in the significance of the p-value with its nonparametric counterpart, i.e., the Kruskal–Wallis test, which, however, would have caused us to suffer a loss of the ability to interpret the results (results of this test can be found in the Appendix B ). Welch’s ANOVAs show a significant main effect of the political orientation both on benefits perceptions with a small effect size [F (3, 493) =14.47; p < 0.001; η 2 = 0.04] and on harms perceptions with a medium effect size [F (3, 497) = 26.94; p < 0.001; η 2 = 0.07]. In particular, post hoc comparisons show that the harms perception of COVID-19 immunity certificates is significantly lower ( p < 0.001) for left-oriented people (M = 2.12, SD = 1.18) and higher ( p < 0.001) for right-oriented people (M = 3.17, SD = 1.26); vice versa, the benefits perception of COVID-19 immunity certificates is higher ( p < 0.001) for left-wing people (M = 3.79, SD = 1.05) and lower for right-wing people (M = 3.19, SD = 1.23). In addition, Welch’s ANOVAs show a significant main effect of having contracted COVID-19 both on benefits perceptions with a small effect size [F (1, 341.66) = 29.42; p < 0.001; η 2 = 0.28] and on harms perceptions [F (1, 351) = 30.23; p < 0.001, η 2 = 0.27]. The results show a statistically significant difference with p < 0.05, with higher benefits perceptions of COVID-19 immunity certificates for those who have contracted COVID-19 (M = 3.52, SD = 1.17) and lower for those who have not contracted it (M = 3.03, SD = 1.17); on the other hand, concerning the harms perception of COVID-19 immunity certificates, the results show a statistically significant difference with p < 0.05, with a lower rate for those who have contracted COVID-19 (M = 2.59, SD = 1.28) and higher for those who have not contracted it (M = 3.11, SD = 1.21). Finally, results show no significant effects of the education on benefits perceptions ( p = 0.081) nor harms perceptions ( p = 0.166) and no significant effects of the gender on benefits perceptions ( p = 0.361) nor harms perceptions ( p = 0.296). 3.3. Multiple Linear Regression Models The multiple linear regression with age, trust in institution, concern for the sanitary emergency, and confidence level for efficiency of vaccines to prevent infective disease as independent variables and perceived benefits as the dependent variable returned a significative model that explains benefits perceptions [F (4, 1017) = 313.00, p < 0.001] with an R 2 of 0.552. All the independent variables had a significative effect on the dependent variable ( p < 0.001) and predicted that a benefits perception of the COVID-19 immunity certificate was equal to 2.74 + 0.55 (confidence level in vaccine efficiency to prevent infective disease) 0.37 (trust in institution) + 0.12 (age) + 0.10 (concern for the COVID-19 emergency). Then, the multiple linear regression with age, trust in institution, concern for the sanitary emergency, and confidence level for efficiency of vaccines to prevent infective disease as independent variables and perceived harms as the dependent variable returned a significative model that explains harms perceptions, but with a lower amount of variance explained [F (4, 1017) = 97.23, p < 0.001] with an R 2 of 0.277. Neither trust in institution ( p = 0.25) nor concern for the COVID-19 emergency ( p = 0.06) have a significant effect on the dependent variable harms perception, while age and confidence level for efficiency of vaccines to prevent infective disease do have a significant effect ( p < 0.001). The predicted harms perception of the COVID-19 immunity certificate was equal to 2.88–0.61 (confidence level for efficiency of vaccines to prevent infective disease) and 0.16 (age). 4. Discussion In this study, we indicate details that could be useful to develop better communication strategies to engage people to better accept restrictive measures for the sake of a common good. Those details, hence, can be considered to envision specific targets to propose-tailored communications that are more relevant and therefore more effective [ 25 ]. In fact, considering perceived benefits separately from perceived harms has shown how there are variables that influence one more than the other. Firstly, results show that considering the multiple linear regression model with age, confidence level for efficiency of vaccines to prevent infective disease, trust in institution, and concern for the COVID-19 emergency, the latter two significatively explain the variance in the perceived benefits while not in the perceived harms of COVID-19 immunity certificates, but the opposite regarding political orientation, which explains perceived harms better than perceived benefits. However, these results show that an initial classification of targets by their demographic variables such as gender or education is not too effective in skimming for perceptions of harms and benefits. In fact, neither gender nor education turn out to have a significant effect in perceptions of benefits or harms. This result is apparently in contrast with previous studies [ 9 , 10 , 26 ], but while those studies investigated opinions regarding a hypothetical immunity certificate, in our study, such a system was already valid at the time of the survey. However, the results show age as a significant sociodemographic explanatory variable for benefits perceptions, which increases with age. This is consistent with previous studies that show a better acceptance for older people [ 5 , 10 ] and could be a relevant result to set up more communication strategies specific for younger people, for example, using infographic messages [ 27 ]. Then, it might be expected that having had the disease—and having experienced firsthand the risk and the discomfort—should increase the perceived benefits and reduce the perceived potential harms of the COVID-19 immunity certificate that, in fact, is a measure to solve the emergency, but looking at the results, it is clear that those who have contracted COVID-19 perceive more of the harms and less of the benefits compared to those who have not. Indeed, this result is in line with a previous study and could be due to the fear of being isolated for a period of time because of this certification system, especially from those who are most likely to be temporarily immune [ 28 ]; in any case, it could be worthwhile to better investigate the reason for this with further studies. Instead, it seems more intuitive that perceived benefits increase as concern about the health emergency increases, but interestingly, it is not as effective at influencing perceptions of harms. This, since the percentage of the population concerned changes over time depending on events [ 29 ], may imply that during the most worrisome periods it is easier to introduce restrictive measures. Regarding political orientation, it turns out that right-wing people perceive more of the harms and less of the benefits of the green pass compared to left-wing people. In another study, it was found that more conservatives scientists would accept the introduction of an immunity passport better [ 4 ]; this difference could be addressed to the special kind of population and the fact that people of right-wing orientation could not be the same [ 30 ]. Although predictable, trust in institutions turns out to be a good predictor of the perceived benefits of the green pass and, therefore, of a restrictive measure for the common good, which is why it may be important to monitor an index of trust toward institutions, such as with a social media analysis [ 14 ], and improve this condition [ 31 ] to increase acceptance of policies for the good of the community [ 8 , 32 ]. However, it is interesting that the perceived harms of such a measure are not addressed, so it might be interesting to investigate the profile of those who perceive more harms than benefits in more depth. Finally, the results of the model clearly show the role of the confidence level for efficiency of vaccines to prevent infectious disease; this, in addition to finding confirmation with very recent studies also in the Italian context [ 33 ], brings to attention the importance of continuing in the effort to reduce vaccine hesitancy by listening to their doubt and by creating space for dialogues with the citizens that can provoke their engagement with the health and social system. The need for policy improvements is pressing because a large share of the world’s population remains unvaccinated, and recent scientific evidence showed a waning of the immune response over time. Moreover, even beyond the current pandemic, our results can serve as vital information for similar health crises that may occur in the future. In addition, our results are expected to offer useful insights into public feelings around the use of digital health information tools. 5. Limitations This study has some limitations that should be considered. The data presented in this study are self-reported and are partly dependent on the participants’ honesty and recall ability; thus, they might be prone to recall, declaration, or desirability biases. Secondly, the sample was limited to the Italian context, and therefore, the collected responses might not be generalizable to other countries. Future research should consider the results of this study with different populations. Author Contributions Conceptualization: S.B., M.P. and L.P.; data curation: M.P. and L.P.; formal analysis: M.P.; methodology: G.G., S.B., L.P., M.A. and M.P.; project administration: G.G.; supervision: S.B.; writing—original draft: M.P., M.A., L.P. and S.B.; writing—review and editing: G.G., S.B., L.P., M.A. and M.P. All authors have read and agreed to the published version of the manuscript. Funding This study was conducted within the CRAFT project, funded by Fondazione Cariplo and Regione Lombardia. The authors declare that the funders had no role in the study design, in interpretation of the results, or in the decision to publish the results. Institutional Review Board Statement This study has been performed in accordance with the Declaration of Helsinki and has been approved by an independent ethics commission of the Department of Psychology of Università Cattolica del Sacro Cuore in Milan (CERPS). Informed Consent Statement Informed consent was obtained from all subjects involved in the study. Data Availability Statement The dataset used for the analysis in this paper is available by emailing the corresponding author ( [email protected] ). The R-script can be found in the attached materials. Acknowledgments The authors wish to thank the study participants for their contribution to the research. Conflicts of Interest The authors declare no conflict of interest. Appendix A Table A1. Survey administered to the study participants. Table A1. Survey administered to the study participants. Variable Name Answer Scale/Categories Item Description Gender Male Female To begin, we ask you some information about you—Gender Politic Centre left Centre Centre Right No Politic Orientation Given your political views, where would you be? Education Middle school or lower Secondary education Degree or more To begin, we ask you some information about you—Level of education Contraction of the COVID-19 Disease Yes No Have you contracted COVID-19 (confirmed diagnosis by molecular or antigenic)? Age Birth year in number To begin, we ask you some information about you—How old are you? Trust in Istitution 5-step Likert-type scale With reference to the emergency situation from COVID-19 that we are experiencing, answer the following questions by indicating how much you agree with the following statements—I have full confidence in the institutions. Concern about COVID-19 5-step Likert-type scale How concerned would you say you are about the COVID-19 emergency? Confidence Level on Vaccine Efficacy to Prevent Infective Disease 5-step Likert-type scale I am confident in the effectiveness of vaccines in preventing infectious diseases. Benefits Perception 1 5-step Likert-type scale I think Green Pass is an effective measure to reduce contagions. Benefits Perception 2 5-step Likert-type scale I think Green Pass is important to protect the health of the most. Benefits Perception 3 5-step Likert-type scale Since Green Pass has existed, I feel safer going to public places. Benefits Perception 4 5-step Likert-type scale I think Green Pass is important to protect public health. Benefits Perception 5 5-step Likert-type scale I think it is right to prevent those who do not have the Green Pass from entering workplaces. Benefits Perception 6 5-step Likert-type scale I think the Green Pass is important to protect the economy. Benefits Perception 7 5-step Likert-type scale I think it is right to prevent access to recreational and social gathering places such as restaurants, nightclubs, and stadiums for those who do not have the Green Pass. Harms Perception 1 5-step Likert-type scale The green pass is a violation of privacy. Harms Perception 2 5-step Likert-type scale I think the green pass is a way for the government to control citizens. Harms Perception 3 5-steps Likert-type scale The green pass greatly infringes on personal freedom. Harms Perception 4 5-steps Likert-type scale I think the green pass only increases inequality. Appendix B Boxplots of age, concern about the COVID-19 emergency, trust in institutions, confidence level of vaccine efficiency to prevent infective disease, benefits perceptions of COVID-19 immunity certificates, and harms perceptions of COVID-19 immunity certificates. Appendix C Diagnostic plots of the benefits perception multiple linear regression model. 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People’s Perspectives about COVID-19 Vaccination Certificate: Findings from a Representative Italian Sample. Vaccine 2022 , in press. [ Google Scholar ] [ CrossRef ] Table 1. Sample characteristics. % n Gender Male 49.3% 504 Female 50.7% 518 Employment Entrepreneur/freelancer 12.4% 127 Manager/official 3.8% 39 Employee/military/teacher 22.1% 226 Worker/shop assistant/apprentice 18.1% 181 Householder 15.0% 153 Student 5.3% 54 Retired 7.9% 81 Unoccupied 15.4% 157 Other 0.3% 4 Education Middle school or lower 17.4% 178 Secondary education 56.1% 574 Degree or more 26.4% 270 Geographical Area Northwest 26.3% 269 Northeast 18.6% 190 Center 19.7% 201 South 35.4% 362 Living center’s size Up to 10.000 32.1% 328 Between 10.001 and 100.000 44.0% 450 Between 100.001 and 500.000 10.9% 111 Above 500.001 13% 133 Table 2. Survey items assessing perceived harms and benefits of the immunity certification implementation. Item Mean S.D. Asymmetry Skewness Benefits Perception (α = 0.952) 3.42 1.18 −0.72 −0.45 I think COVID−19 immunity certificate is an effective measure to reduce infections 3.28 1.35 −0.45 −0.96 I think COVID-19 immunity certificate is important to protect the health of the most fragile people 3.59 1.32 −0.70 −0.59 Since the existence of the COVID-19 immunity certificate I feel safer going to public places. 3.19 1.25 −0.39 −0.74 I think COVID-19 immunity certificate is important to protect public health. 3.52 1.31 −0.65 −0.62 I think it’s fair to prevent people who don’t have COVID-19 immunity certificate from entering workplaces. 3.46 1.40 −0.57 −0.92 I think COVID-19 immunity certificate is important to protect the economy. 3.27 1.31 −0.37 −0.88 I think it is fair to prevent access to recreational and social gathering places such as restaurants, nightclubs, and stadiums to those who do not have COVID-19 immunity certificate 3.61 1.35 −0.74 −0.61 Item Mean S.D. Asymmetry Skewness Harms Perception (α = 0.902) 2.70 1.28 −0.27 −1.06 I think it is fair to prevent access to recreational and social gathering places such as restaurants, Nightclubs, and stadiums to those who do not have COVID-19 immunity certificate 2.54 1.47 0.42 −1.22 COVID-19 immunity certificate is a violation of citizens’ privacy 2.72 1.42 0.20 −1.24 I think the COVID-19 immunity certificate is a way for the government to control the citizens 2.67 1.49 0.30 −1.30 COVID-19 immunity certificate strongly violates personal freedom 2.87 1.45 0.09 −1.31 MDPI and ACS Style Barello, S.; Paleologo, M.; Palamenghi, L.; Acampora, M.; Graffigna, G. Public Perceptions of Harms and Benefit of COVID-19 Immunity Certificate: A Cross-Sectional Study in the Italian Setting. Vaccines 2022, 10, 1501. https://doi.org/10.3390/vaccines10091501 Barello S, Paleologo M, Palamenghi L, Acampora M, Graffigna G. Public Perceptions of Harms and Benefit of COVID-19 Immunity Certificate: A Cross-Sectional Study in the Italian Setting. Vaccines. 2022; 10(9):1501. https://doi.org/10.3390/vaccines10091501 Barello, Serena, Michele Paleologo, Lorenzo Palamenghi, Marta Acampora, and Guendalina Graffigna. 2022. "Public Perceptions of Harms and Benefit of COVID-19 Immunity Certificate: A Cross-Sectional Study in the Italian Setting" Vaccines10, no. 9: 1501. https://doi.org/10.3390/vaccines10091501
https://www.mdpi.com/2076-393X/10/9/1501/html
South Africa - Creative Commons South Africa Revision as of 21:42, 11 March 2012 by Tittbit ( talk | contribs ) ( → ‎ Community ) AFFILIATE TEAM ROADMAP Date submitted : 26 January 2011 Timespan of this roadmap : January 2011 to December 2011 Team information Jurisdiction : South Africa Complete list of all members of the Affiliate Team, their roles, and field(s) of expertise Public leads : Dave Duarte [marketing] and Max Kaizen [research and evangelism] Legal lead : Dr Tobias Schonwetter [copyright specialist] Technical lead : Paul Scott [founder Chismba, open source lms] Date of latest MOU in jurisdiction 25 May 2009 (University of Cape Town, Prof Julian Kinderlerer) 25 May 2009 (legal affiliate Tobias Schonwetter) 24 June 2008 (public affiliate David Duarte) Self-Identified Region(s) , i.e. Europe, Africa, Asia-Pacific, Latin America, North America, Arab world: Southern Africa Why do you identify yourself as being part of the listed region(s)? That's where we are! Vision Why is Creative Commons important for the jurisdiction? Emerging creatives need free and shareable resources to build on. Exposure of Southern African creativity to other markets through open licensing. South African political leaders are suspicious of internet freedom, so this needs to be protected, and the cause for internet freedoms needs to be embedded. What do you think makes a successful jurisdiction project? Broad awareness and use of CC among individuals, businesses, private and public institutions. Public dialogue around internet freedoms, including CC. Partnership with related organisations and non-profits Use of CC in OER in universities and schools. Self-sustaining, active community of volunteers and supporters. How do you see the jurisdiction project contributing to the CC Affiliate Network? Localized licenses in an important emerging economy Add an African perspective to CC related discussions. To help kick-start CC projects in other African countries. Introducing more African works into the CC pool. Community Describe the communities that are currently active in the project. Universities, software programmers, media geeks, musicians, authors, publishers, marketers How will you continue to engage with these communities? We will increase our engagement through: Conference talks, website, Twitter, Legal advice, email . Describe the communities (existing or new) that you plan to focus on during the timeframe covered by this roadmap? Universities + OER community, Artists How do you plan to engage with these communities? Twitter, CC SA website, Other Websites and social networks, Conference talks, Workshops. Priority Goals What are the three most important focus areas on which the Affiliate Team will work during this time period? Please consider community building and adoption goals among your priorities. 1. Focus-area: License 3.0 Why is it important? License contains important improvements on v.2.5 Which communities will benefit? All users of CC 2. Focus-area: Website Update This includes things like: a collection of case-studies or organisations using CC in South Africa (wiki); Monthly news (at the minimum); Acknowledge all CC SA volunteers and organizational supporters; Put more information about Creative Commons Licensing (including videos) - linking; Links and feeds to and from our other social media profiles Why is it important? This is most people's first stop in getting more information about Creative Commons South Africa. It's the virtual home of the community. Which communities will benefit ? All CC South Africa stakeholders. 3. Focus-area: Open Education Resources Localized Statement Why is it important? Many university players have not yet understood that CC is an important part in making OER work. It's a hot topic, which is an opportunity to align ourselves with a relevant and important cause. Which communities will benefit? Universities and Schools. 4. Getting organizational support , where other companies will offer to provide resources for us, such as printing & Public Relations services. A list of companies who are prepared to volunteer their services in kind so we know who to call on if necessary. 5. Join the discussions around the new "IPR from Publicly Financed Research and Development Act" (BAYH - DOLE - like legislation) in South Africa through the website, conference talks, Debates, Petitions & Twitter. Project Outputs Detail tangible project outputs (e.g., events, papers, blog posts, video/films, etc.) for each focus area including an expected date of completion. See also Timeline. The outputs we plan to complete are as follows: Focus-area: 3.0 licences for South Africa Project Output: 3.0 licences for South Africa Expected start date: already started - Expected date of completion: June 2011 Team Member(s) Responsible: Tobias Schonwetter How will this output help achieve your goals? Having the most up to date licences is crucial for project success and also shows the commitment of the team. Focus-area Project Output: Website update Expected start date: 26 January 2011 - Expected date of completion: 31 March 2011 and ongoing thereafter Team Member(s) Responsible: Max Kaizen, with support by all team members, especially Paul Scott How will this output help achieve your goals? see above Focus-area Project Output: localised OER statement Expected start date: already started - Expected date of completion: 28 February 2011 Team Member(s) Responsible: Dave Duarte How will this output help achieve your goals? It adds our voice to the discussion in this field and will clarify the close link between OERs and CC Focus-area: Twitter CC licences for South Africa Project Output: easy-to-grab licenses for South African Twiiter users Expected start date: already started - Expected date of completion: 26 Jan 2011 Team Member(s) Responsible: Paul Scott How will this output help achieve your goals? Awareness of CC and particularly to help answer the localised jurisdiction of CC. Followers to CC South Africa’s tweetstream develops the community and exposes them to news and resources from the team. Metrics Please consider using trackable statistics (such as web traffic or number of license adoptions) when applicable, but only if meaningful. How will you measure and evaluate your impact on focus-area 1? N/A How will you measure and evaluate your impact on focus-area 2? N/A How will you measure and evaluate your impact on focus-area 3? N/A Resources Required People What human resources or expertise must the team seek out or add to your existing resources, if any, in order to achieve your priority goals? In 2010, we identified the need to add a "technical lead" to the team and Paul Scott has joined the team to fill this gap (no MoU signed yet). The public lead position is currently being transition to a new lead with the current lead remaining actively involved still. The legal lead has a loose network of supporters to assist with the licence update. How will you involve these people? They are already involved, we have monthly meetings and supporters will be acknowledged on the website. Technology What technology resources must the team seek out or add to your existing resources, if any, in order to achieve your priority goals? How will you obtain these technology resources? Materials What material resources must the team seek out or add to your existing resources, if any, in order to achieve your priority goals? It would be fantastic if CC international could supply us with merchandise and other marketing materials free of charge!!! How will you obtain these material resources? Just send it by post ;-) Other What other resources must the team seek out or add to all the other resources, if any, in order to achieve your priority goals? How will you obtain these other resources? Sustainability and Scalability How will you ensure your goals will be completed if unforeseen circumstances interrupt the project, such as changes in the leadership of the project or outputs taking longer to complete than anticipated? Regular meetings and open discussions among team members; through community discourse and accountability How will you communicate the project's on-going progress and setbacks within the jurisdiction and the CC Affiliate Network? (e.g. email list updates, meetings, press releases) : emails, website, social media platforms, meetings How will you document the project so that others may replicate or learn from your efforts? Creative Commons wiki and our website (and through all of the above communication tools for that matter) Collaboration Please have a look at other roadmaps. How could the jurisdiction's plans help drive or support other jurisdictions' activities? CC South Africa considers itself a pioneer project for CC licensing in Africa and therefore strives to support interested individuals and organisations on the African continent to also initiate CC licensing projects. Such support will include participation in/ administration of CC Africa mailing list, active offering of advice in relation to porting CC licences. The the extent possible, f2f meetings and workshops. What are other jurisdictions doing that might support or contribute to the project? Some countries, such as the Australian CC project's site, have more advanced website offerings from which we can learn. CC Brazil appears to have succeeded in building strong cultural relevance that we would like to a emulate. Would you be interested in mentoring new jurisdiction teams? Yes, see above. Conversely, would you be interested in having a mentor from a more experienced jurisdiction team? Yes, see above. Regional Suggest three possible projects on which you can collaborate with other teams on a regional level. If you are not yet involved with the regional network, please contact the regional spokesperson (if any) or notify CC HQ to put you in touch with others. Adoption of CC licences in other African (exchanging experiences etc and guidelines of how to approach this issue). Since there are no other teams yet in our region (Southern Africa), no opportunity for collaboration exists. However, we will look at collaboration opportunities with country project in other African countries, such as Egypt, Kenya and Nigeria, as they arise. How do you plan to contribute to these projects? Sharing of information and on an ad hoc basis. Translation In what language(s) will you promote CC in the jurisdiction and why? At this point in time, it is only feasible to promote CC licences in English. Yet, we aim at translating the Commons Deed into several of our official language if volunteers for this can be found. At least 2 such translations of the Commons Deed already exist. In which of these languages are licenses already available? CC0? English. We haven't dealt with the CC0 "licence" yet. Into which of the remaining languages do you intend to translate the licenses? CC0? see above. How will you involve the local language(s) community? Once we have updated our licences to v3.0, we will get in touch with non-profit translation organisations such as www.translate.org.za and ask for their support on this matter. In addition, we will on our website encourage volunteers to help out. License Archives License draft . English explanation of substantive legal changes . See the project website . Subscribe to the discussion . Subscribe to the weekly mailing list . More about the UCT Intellectual Property Law Research Unit The UCT Intellectual Property Law Research Unit is housed at the Department of Private Law at the University of Cape Town Law School. Acknowledgments Creative Commons South Africa was founded by Heather Ford (public lead), and Andrew Rens (legal lead) and based at the LINK Centre . More details and a retrospective on CC South Africa by Andrew Rens on his blog . The LINK Centre is the leading research and training body in the field of information and communications technology (ICT) policy, regulation and management in Southern Africa. Retrieved from " https://wiki.creativecommons.org/index.php?title=South_Africa&oldid=55747 " Categories : CC Affiliate Locale Affiliate Active
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(PDF) Long-term expression of full-length human dystrophin in transgenic mdx mice expressing internally deleted human dystrophins PDF | One of the possible therapies for Duchenne muscular dystrophy (DMD) is the introduction of a functional copy of the dystrophin gene into the... | Find, read and cite all the research you need on ResearchGate Long-term expression of full-length human dystrophin in transgenic mdx mice expressing internally deleted human dystrophins DOI: 10.1038/sj.gt.3302242 Abstract and Figures One of the possible therapies for Duchenne muscular dystrophy (DMD) is the introduction of a functional copy of the dystrophin gene into the patient. For this approach to be effective, therapeutic levels and long-term expression of the protein need to be achieved. However, immune responses to the newly expressed dystrophin have been predicted, particularly in DMD patients who express no dystrophin or only very truncated versions. In a previous study, we demonstrated a strong humoral and cytotoxic immune response to human dystrophin in the mdx mouse. However, the mdx mouse was tolerant to murine dystrophin, possibly due to the endogenous expression of dystrophin in revertant fibres or the other nonmuscle dystrophin isoforms. In the present study, we delivered human and murine dystrophin plasmids by electrotransfer after hyaluronidase pretreatment to increase gene transfer efficiencies. Tolerance to murine dystrophin was still seen with this improved gene delivery. Tolerance to exogenous recombinant full-length human dystrophin was seen in mdx transgenic lines expressing internally deleted versions of human dystrophin. These results suggest that the presence of revertant fibres may prevent the development of serious immune responses in patients undergoing dystrophin gene therapy. Dystrophin expression in mdx transgenic lines. (a) Left panel shows Western blot analysis of dystrophin expression and the right-hand panel shows immunostaining of muscle from the microdystrophin transgenic with human dystrophin-specific monoclonal Dy10/12B2 showing perinuclear and sarcolemmal localization of the transgene product. Scale bar=50 m. (b) Muscle histology and dystrophin staining of TA muscles from C57/Bl10 (wildtype, WT) mice, mdx and the microdystrophin transgenic line. H&E shows the variable sized central nucleated fibres as a sign of regeneration in the mdx and microdystrophin transgenic muscle and peripheral nuclei in the C57/Bl10. The dystrophin staining with antibody DysC3750 at a 1:2000 dilution shows the presence of dystrophin at the sarcolemma of the muscle fibres in the C57/Bl10 mouse, in revertant fibres in the mdx mouse but no sarcolemmal staining in the microdystrophin transgenic line. Scale bar=0.1 mm. … Dystrophin expression in mdx transgenic lines. (a) Left panel shows Western blot analysis of dystrophin expression and the right-hand panel shows immunostaining of muscle from the microdystrophin transgenic with human dystrophin-specific monoclonal Dy10/12B2 showing perinuclear and sarcolemmal localization of the transgene … Graph showing the maximum number of revertant fibres detected in transverse sections of mdx TA muscle subjected to different variants of the hyaluronidase plus electrotransfer procedure. Each bar represents the mean 7 s.e.m. Stippled white bar shows saline preinjection, n 1⁄4 9; stippled grey bar shows saline preinjection þ saline electrotransfer, n 1⁄4 4; stippled black bar shows saline preinjection þ CMV0 electrotransfer, n 1⁄4 5; white bar shows hyaluronidase preinjection, n 1⁄4 9; grey bar shows hyaluronidase preinjection þ saline electrotransfer, n 1⁄4 4; and the black bar shows hyaluronidase preinjection þ CMV0 electrotransfer, n 1⁄4 5. There are no significant differences between any of the groups. … TA muscles of mdx mice 1 week (black bars) and 8 weeks (grey bars) after injection of (a) Full-length murine dystrophin plasmid and (b) Full-length human dystrophin plasmid. Each bar represents the mean of six mices.e.m.; there is no significant difference between 1 and 8 weeks in the murine dystrophin-injected muscles, but there is a significant decrease in the number of human dystrophin-positive fibres between 1 and 8 weeks. (c and d) show Western blots of muscle lysates from C. mdx (no dystrophin) and C57Bl10 muscle (murine dystrophin) or D. mdx and AD17 (overexpressing human dystrophin), probed with pooled serum from the mice shown in (a) and (b), respectively. 6C5 is the control antidystrophin monoclonal antibody Dy8/6C5. There is a strong humoral response to human dystrophin and a very weak response to murine dystrophin. Blots were simultaneously probed with a monoclonal antibody recognizing metavinculin and vinculin as a loading control. … RESEARCH ARTICLE Long-term expression of full-length human dystrophin in transgenic mdx mice expressing internally deleted human dystrophins A Ferrer 1 , H Foster 1,3 , KE W ells 1 , G Dickson 2 and DJ W ells 1 1 Gene T argeting Unit, Department of Neuromuscular Diseases, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital, London, UK; and 2 Center for Biomedical Sciences, School of Biological Sciences, Royal Holloway , University of London, Surr ey , UK One of the possible therapies for Duchenne muscular dystrophy (DMD) is the introduction of a functional copy of the dystrophin gene into the patient. For this approach to be effecti ve, therapeutic levels and long-term expressi on of t he protein need to be achieved. However, immune responses to the newly expressed dystrophi n have been predicted, particularly in DMD patients who express no dystrophin or only very truncated versions. In a previous study, w e demonstrated a strong humoral and cytotoxic immune response to human dystrophin in the mdx mouse. However, the mdx mouse was tolerant to murine dystrophin, possibly due to the endogenous expressi on of d ystrophin in revertant fibres or the other nonmuscle dystrophin isoforms. In the present study, we delivered human and murine dystrophin plasmids by electrotransfer after hyaluronidase pretreatment to increase gene transfer efficien- cies. Tolerance to murine dystrophin was still seen with this improved gene delivery. Tolerance to exogenous recombinant full-length human dystrophin was seen in mdx transgenic lines expressing internally deleted versions of human dystrophin. These results suggest that the presence of revertant fibres may prevent the development of serious immune responses in patients undergoing dystrophin gene therapy. Gene Ther apy (2004) 11, 8 84 –8 93 . do i: 10.1038/sj.gt.3302242 Published online 26 February 2004 Keywords: dystrophin; mdx; transgenic; tolerance Introduction Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disorder affecting 1:3500 male births. 1 It is characterized by a progr essive loss of muscle mass and replacement of myofibres with connective and adipose tissue. The severe myopathy observed in DMD patients is due to the complete absence or substantial reduction of dystrophin at the sarcolemma of the muscle fibres. This is caused by mutations in the dystrophin gene that alter the open-reading frame of dystrophin. 2 The 427 kDa skeletal form of dystrophin has 3685 amino-acid residues and cont ains sever al doma ins: the amin o-te rminu s doma in that binds cy tosk elet al acti n filam ents , a la rge rod -sha ped do main formed by 24 repeat se quen ces th at ar e pred icted to adopt a triple helical co nfor mati on with four hinges and a carbox yl-t ermi nus domain that binds a who le comp lex of dy str ophi n-as so ciated protei ns at th e sarcol emma . 3 By bindi ng to b -d ystr og lyca n at the memb rane , dystr ophin acts as a phys ical link be tw een the cytoske leto n an d the extracel lula r ma trix . An alleli c form of this di seas e, Beck er musc ular dyst rop hy (BMD) , is asso ciat ed wit h an inter nall y dele ted dystr op hin mo lecu le due to muta tion s that mainta in the r eadi ng frame. 2 This mild er form of dystr ophy is char acte rize d by a later onset and a slower prog r essi on of muscl e de gene rati on. An animal model for DMD is the mdx mouse whose mutation in exon 23 in the murine dystrophin gene results in a premature stop codon 4 and so the full-length 427 kDa muscle isoform of dystrophin is not produced. However , the other isoforms produced from different promoters 3 0 of the point mutation are unaf fected (Figure 1). Despite the lack of dystrophin in the mdx muscle, some fibres show dystrophin staining at the sarcolemma. The number of these so-called revertant fibres is low , normally present at ar ound 1% of total fibres, 5 although their number increases with the age of the mice. 6 There are many strategies for the induction of de novo dystrophin expression as a therapeutic approach for the treatment of DMD. These include systemic drug deliv- ery , 7 gene modification at DNA and RNA levels, 8–1 1 cell transplantation 12–14 and gene delivery with a wide range of both viral 15–17 and nonviral 18–20 delivery systems. However , therapeutic levels, together with a stable long- term presence of dystrophin at the sarco lemma of the muscle fibres, are essential. One major factor that could jeopardize the long-term persistence of dystr ophin is an immune response directed against the genetically mod- ified fibre. It has been suggested that the introduction of the complete dystrophin would act as a neoantigen, Received 30 August 2003; accepted 10 January 2004; published online 26 February 2004 Correspondence: DJ Wells, Gene T argeting Unit, Department of Neuromuscular Diseases, Division of Neur oscience and Psychological Medicine, Imperial College London, Charing Cross Hospital, St Dunstan’ s Road, London W6 8RP , UK 3 Current addr ess: Center for Biomedical Sciences, School of Biological Sciences, Royal Holloway, University of London, Surrey TW20 0EX, UK Gene Therapy (2004) 11 , 884–893 & 2004 Nature Publishing Group All rights reser ved 0969-7128/04 $ 25.00 www .nature.com/gt as the DMD patient’s immune system would not have seen some, or all, of the epitopes present in the full- length protein. 21 Immune responses to dystrophin have been reported in early myoblast transfer experiments, where only transient expression of dystrophin was achieved. 22 The delivery of dystrophin with viral vectors to animal models has also shown short-term expression of dystrophin in muscle fibres, 23 unless an immunosup- pressive regime was used. 24 In most cases, it was not clear if the immune response was directed to the transgene itself or if this immune response was enhanced due to the vector system used, that is, cellular compo- nents or viral coat proteins. W e and others have demonstrated that following the direct intramuscular injection of naked plasmid DNA expressing dystrophin in the mdx mouse, an immune response leads to a loss of fibr es transfected with human dystrophin by 8 weeks postinjection, 18,19 but no immune r esponse to murine dystrophin was detectable by 12 weeks. 18 However , the overall numbers of dystrophin-positive fibr es obtained by direct intramuscular injection of plasmid DNA was very low and so there was a formal possibility that the expression of gr eater amounts of antigen could break the tolerance observed in this experiment. In the current study , plasmid DNA encoding full-length mur- ine or human dystrophin driven by the CMV promoter was electroporated into the tibialis anterior (T A) muscles of mdx mice 2 h after treatment with hyaluronidase, as this procedure has been shown to achieve high transfection efficiencies in muscle. 20,25 W e also investi- gated whether revertant fibres and/or expression of different dystrophin isoforms contribute to the tole- rance to murine dystrophin. The role of the other smaller isoforms of dystrophin in inducing tolerance was examined in mdx3cv mice, a strain of the mdx mouse with a mutation in exon 65 and that does not produce any of the dystrophin isoforms. 26 T o investigate as to how much of the human dystrophin molecule is required to provide tolerance to de novo expres sion of full-length human dystrophin, we examined immune responses to electrotransfer of a human dystrophin construct into mdx transgenic lines expressing a range of internally deleted recombinant human dystrophin molecules. Results Analysis of the microdystrophin transgenic mdx line The microdystrophin transgenic line expresses a human microdystrophin with deletion of exons 13–48 (Figure 1) compared to the deletion of exons 17–48 in the previously published minidystrophin transgenic line (AB2). 27 W estern blot analysis of skeletal muscle RIP A buffer preparations from this microdystrophin trans- genic mdx line, control C57Bl10 and minidystrophin mice indicate equivalent total dystrophin expression levels in the minidystrophin and microdystrophin transgenic lines (Figure 2a, left panel). Staining with the human specific antibody Dy10/12B2 confirms the species of dystrophin expres sed in the micr odystrophin line (Fig- ure 2a, right panel). In addition to the sarcolemmal- associated stain, there was a degree of perinuclear stain, suggesting that the recombinant dystrophin was not being efficiently translocated to the membrane. The microdystrophin transgenic line has a moderate dys- trophic phenotype with regions in which myofibres show centrally placed myonuclei on haematoxylin and eosin staining, indicating previous rounds of muscle degeneration and regeneration (Figure 2b). The micro- dystrophin line shows a level of dystrophin expression at the sarcolemma similar to that seen in the minidystro- phin line when using rabbit polyclonal DysC3750 over a range of dilutions. 20,28 As shown in Figure 2b, at a dilution of 1:2000, the endogenous signal in the C57/Bl10 wild-type mouse tissue and in revertant fibres in the mdx is still clearly visible, but staining of the trans- gene product is not detectable in the transgenic line (Figure 2b). Does the hyalur onidase and electrotransfer procedure increase the number of revert ant fibres? In our analysis of the number of dystrophin-positive fibres following gene transfer in the injected leg, we subtract the number of revertant fibres in the control uninjected leg. T o investigate whether the plasmid electrotransfer procedure per se increases the number of revertant fibres in the injected leg, 13- to 14-week-old mdx mice were subjected to the following treatments: preinjection of saline ( n ¼ 9) or preinjection of saline followed by electrotransfer of either saline ( n ¼ 4) or CMV0 plasmid ( n ¼ 5), preinjection of hyaluronidase ( n ¼ 9) or preinjection of hyaluronidase followed by electrotransfer of either saline ( n ¼ 4) or CMV0 plasmid ( n ¼ 5). The r evertant fibre counts show that there were no significant differences between any of the groups; however , the trend shows a decrease in the number of revertant fibres in the electroporated legs compared to the nonelectroporated ones (Figure 3). Electrotransfer of human and murine full-length dystrophin constructs into mdx and mdx3cv mice Immune r esponses to the expression of dystrophin were assessed after hyaluro nidase pretr eatment and electro- transfer of plasmid DNAs encoding full-length human or murine dystrophin. Mdx mice (1 1 week old) were injected in the right T A with either human (CDF) or Figure 1 Diagrammatic representation of full-length dystrophin and the internally deleted versions present in the mdx transgenic lines. The diagram shows the four main domains: actin-binding domain (ABD), four hinges (H1–4), 24 spectrin-like repeats, cysteine-rich (CR) and carboxy- terminus domain (CT). , indicates the start of the sequence overlap present in the indicated dystr ophin isoforms expr essed from internal promoters; * , indicates the site of the point mutation in the mdx mouse; #, indicates the site of the point mutation in the mdx3cv mouse. Long-term expression of full-length human dystrophin in mdx mice A Ferrer et al 885 Gene Therapy murine (CMVmoDys) dystrophin-encoding plasmids. The control left T A was injected with the noncoding plasmid CMV0. Mice were killed 1 or 8 weeks postplasmid injection and T A sections were stained for dystrophin expression using DysC3750 at 1:2000. At 1 week postinjection, mice injected with either construct showed similar numbers of dystrophin-positive fibres (Figure 4a and b). However , by 8 weeks postinjection, the number of human dystrophin-positive fibres had dropped significantly ( P o 0.001, Figure 4b), consistent with our previously reported data for intramuscular injection of plasmid DNA, 18 whereas no differ ence was found in the number of murine dystr ophin-expressing fibres between both time points (Figure 4a). At 8 weeks postinjection of murine dystrophin, there was a non- significant increa se in CD8 þ infiltrate in the treated mdx muscle (51.6 7 49.4 additional CD8 þ cells per mm 2 ) above that of the untreated muscle and a similar pattern was seen 8 weeks postinjection of the human dystrophin construct (40.3 7 23.4 additional CD8 þ cells per mm 2 ). Despite the higher number of fibres transfected with murine dystrophin after the combined hyalur onidase and electrotransfer procedure compared with multiple direct injection, 18 only a very low level of antibodies against murine dystrophin was detected by W estern blot analysis when the murine dystrophin construct was Figure 2 Dystrophin expression in mdx transgenic lines. (a) Left panel shows Western blot analysis of dystrophin expression and the right-hand panel shows immunostaining of muscle from the microdystrophin transgenic with human dystro phin-specific monoclonal Dy10/12B2 showing perinuclear and sarcolemmal localization of the transgene product. Scale bar ¼ 50 m m. (b) Muscle histology and dystr ophin staining of T A muscles from C57/Bl10 (wildtype, WT) mice, mdx and the microdystr ophin transgenic line. H&E shows the variable sized central nucleated fibr es as a sign of regeneration in the mdx and microdystr ophin transgenic muscle and peripheral nuclei in the C57/Bl10. The dystrophin staining with antibody DysC3750 at a 1:2000 dilution shows the presence of dystrop hin at the sarcolemma of the muscle fibres in the C57/Bl10 mouse, in revertant fibres in the mdx mouse but no sarcolemmal staining in the microdystro phin transgenic line. Scale bar ¼ 0.1 mm. Figure 3 Graph showing the maximum number of revertant fibres detected in transverse sections of mdx T A muscle subjected to different variants of the hyaluronidase plus electrotransfer procedure. Each bar represents stippled grey bar shows saline pr einjection þ saline electrotransfer , n ¼ 4; stippled black bar shows saline preinjection þ CMV0 electrotransfer , n ¼ 5; white bar shows hyaluronidase preinjection, n ¼ 9; grey bar shows hyaluronidase pr einjection þ saline electrotransfer , n ¼ 4; and the black bar shows hyalur onidase preinjection þ CMV0 electrotransfer , n ¼ 5. There are no significant differences between any of the groups. Figure 4 (a and b) show the maximum number of dystrophin-positive fibres, after subtraction of revertants, in transverse sections of T A muscles of mdx mice 1 week (black bars) and 8 weeks (grey bars) after injection of (a) Full-length murine dystrophin plasmid and (b) Full-length human dystrophin plasmid. Each bar represents the mean of six mice 7 s.e.m.; there is no significant difference between 1 and 8 weeks in the murine dystrophin-injected muscles, but there is a significant decrease in the number of human dystrophin-positive fibres between 1 and 8 weeks. (c and d) show Western blots of muscle lysates from C. mdx (no dystrophin) and C57Bl10 muscle (murine dystrophin) or D. mdx and AD17 (over- expressing human dystrophin), pr obed with pooled serum from the mice shown in (a) and (b), respectively. 6C5 is the control antidystrophin monoclonal antibody Dy8/6C5. There is a strong humoral response to human dystrophin and a very weak response to murine dystrophin. Blots were simultaneously probed with a monoclonal antibody recognizing metavinculin and vinculin as a loading control. A Ferrer et al 886 Gene Therapy injected into mdx mice (Figure 4c). However , a marked antibody response to dystrophin was found in the sera from mdx mice injected with human dystrophin plasmid CDF (Figure 4d). This response is dystr ophin specific as these antibodies bind to dystrophin in the human dystrophin positive AD17 lysate, but not to the mdx lysate. W e also examined the number of murine dystrophin- positive fibres after electrotransfer of CMVmoDys into the T A muscles of 9-week-old mdx3cv mice. In this and consecutive experiments, the left leg was left untreated. As previously seen in the mdx mice, there was no significant difference in the number of murine dystro- phin-positive fibres present in the muscle of mdx3cv mice at 1 and 8 weeks postinjection (Figure 5). The muscles from the mdx3cv mice presented a very small increase in CD8 þ infiltrate compared to the uninjected leg (3.8 7 2.9 additional CD8 þ cells per mm 2 evidence of clustering specific to murine dystrophin- transfected fibres. No antibody response to murine dystrophin was detected in the treat ed mice (data not shown). Direct injection of human full- length dystrophin into transgenic mdx mice expressing human recombinant mini-dystrophin The transgenic line AB2 expres ses human minidystro- phin, with deletions of exons 17–48 that encode part of the rod domain. Minidystrophin transgenics and mdx littermates (6 to 11 weeks old) received one dose of human full-length plasmid (PTG1 1025) in muscles treated previously with BaCl 2 to induce muscle regen- eration and so enhance plasmid gene transfer . At 8 weeks after the injection of the full-length human plasmid, there were dystrophin-positive fibres present in the transgenic muscles, whereas there was a significantly lower number of dystrophin-transfected fibres in the mdx nontransgenic littermates ( P ¼ 0.048, Figure 6) . The level of CD8 þ infiltrate in the treated legs of the transgenic (123.4 7 39.8 2 ) and mdx littermates (124.7 7 44.4 additional CD8 þ cells per mm 2 ) was not significantly different, but both were significantly higher than the levels in the contralateral untreated muscles ( P ¼ 0.001). W estern blot analysis against human dystrophin protein extracts demonstrated no antidystrophin anti- bodies in the serum from transgenic mice, but mdx littermates exhibited a clear antibody response to dystrophin very similar to that shown in Figure 4d (data not shown). Electrotransfer of human full-lengt h dystrophin constructs into transgenic mdx mice expressing human recombinant microdystrophin Human full-length plasmid CDF was electroporated into the left T A of a group of 14–19-week-old microdystro- phin transgenic mice and mdx littermates leaving the right leg uninjected. At 8 weeks after injection, a significantly higher number of dystrophin-positive fibres were present in the injected muscles of the microdystro- phin transgenics compared to the number of positive fibres observed in the mdx nontransgenic littermates ( P ¼ 0.001, Figure 7a). The experiment was repeated in 18- to 19-week-old microdystrophin transgenic mice and mdx littermates. An average of over 200 dystrophin-positive fibres was present in the T A muscles of microdystrophin transgenic mice 8 weeks postinjection, with dramatically fewer dystrophin-positive fibres observed in nontransgenic mdx littermates ( P ¼ 0.001, Figure 7b). All muscles from the microdystrophin transgenic mice showed a very low degree of CD8 þ infiltrate, whereas mdx mice showed a slightly higher degree of CD8 þ cells. In experiment 1, this difference was significant Figure 5 Graph showing the maximum number of dystrophin-positive fibres, after subtraction of revertants, in transverse sections of T A muscles of mdx3cv mice 1 week (black bars) and 8 weeks (grey bars) after the injection of full-length murine dystr ophin plasmid. Each bar repr esents the mean of six mice 7 s.e.m. There is no significant difference between the number of dystrophin-positive fibres at 1 and 8 weeks. Figure 6 Graph showing the maximum number of dystrophin-positive fibres, after the subtraction of revertant fibres, in transverse sections of T A muscles of minidystrophin transgenic mice and their nontransgenic mdx littermates 8 weeks after the injection of full-length human dystro phin plasmid. Each bar repres ents the mean of seven mice 7 s.e.m. There are significantly more dystrophin-positive fibres in the minidystrophin transgenics compared to mdx littermates. Long-term expression of full-length human dystrophin in mdx mice A Ferrer et al 887 Gene Therapy ( P ¼ 0.002, 0.5 7 0.4 additional CD8 þ cells per mm 2 in the transgenics compar ed to 78.5 7 60.2 additional CD8 þ cells per mm 2 in the mdx littermates), but in experiment 2, there was no difference (2.5 7 2.9 additional CD8 þ cells per mm 2 in the transgenics compared to 1.9 7 2.3 additional CD8 þ cells per mm 2 in the mdx littermates). A faint antidystrophin antibody response was detected in the serum from the microdystrophin transgenics in the first experiment (data not shown), but no response was noted in the transgenics in the second experiment (Figure 7c). In contrast, a very str ong antibody titre was present in the serum from mdx littermates (Figure 7c). Discussion A number of treatments aimed at correcting the dystrophic phenotype have been developed. One pro- mising approach is the introduction of a functional copy of the dystrophin gene that expresses the protein at therapeutic levels. T ransgenic mice expressing human 27 or murine 29 dystrophin cDNAs have shown that expres- sion of the transgene at levels equivalent to 20–30% of endogenous dystrophin at the sarcolemma can correct the myopathic phenotype. Although the expression of a Becker-like minidystro- phin gene can restore the normal phenotype in trans- genic mdx muscle, ideally gene therapy for DMD should involve the delivery of the full-length DNA. For example, nNOS localization to the sarcolemma requires elements of the rod domain that are missing in the recombinant minidystrophin. 30,31 Plasmid DNA is able to accommodate the 14 kb full-length cDNA and has been used to deliver the dystrophin gene into the muscles of mdx mice, 18,32,33 although with a low efficiency . Recently , the use of electroporation to introduce plasmids into muscle has increased gene transfer efficiency , 25 including delivery of full-length dystrophin into the skeletal muscle of mdx mice. 20,34,35 For viral-based delivery , adenoviral vectors have been engineered with deletion of all viral sequences, except for those required for packaging of the virus. These so-called ‘gutted’ adeno- viruses have a high cloning capacity and are able to 16 and mouse 16,17 full-length dystrophin into the mdx muscle achieving very high levels of transfection and improved muscle function. W e have previously shown that there is destruction of the muscle fibre s expressing human full-length in the mdx mouse but not in the immunodeficient mdx /nude mouse. 18 Dystrophin is a structural protein present in the inner part of the muscle sarco lemma, so it is unlikely that circulating antibodies could bind to dystrophin and destroy an otherwise intact muscle fibre. A cytotoxic T -cell response is a more likely mechanism as the destruction of muscle fibres seen in the mdx mouse was not seen in the T -cell-deficient mdx /nude mouse. Indeed, previous studies noted clusters of CD8 þ cells surround- ing dystrophin-positive fibres in the treated mdx muscles together with an IgG 18 and a weak positive dystrophin-specific T -cell ELISPOT in vitro assay . 19 In contrast, when murine full-length dystr ophin driven by a muscle-specific promoter was injected into mdx mice, muscle fibres expressing dystr ophin persisted for at least 12 weeks and no antibody or CD8 þ T -cell response was noted. 18 In the present study , we delivered both human and murine full-length dystrophin cDNAs under the contro l of a CMV promoter . The CMV promoter allows the expression of the dystrophin transgene in many cell types, 36 including pro fessional antigen-presenting cells (APCs). While the mechanism of crosspriming seems to be the most likely after intramuscular DNA injection, 37 it transfected and antigen expression in these APC primes MHC class I and II responses. W e also increased the dose of antigen delivered to the mdx mouse by using the electrotransfer and hyaluronidase pretreatment protocol, Figure 7 Graphs showing the maximum number of dystrophin-positive fibres, after the subtraction of revertants, in transverse sections of T A muscles of micro dystrophin mdx transgenic mice and their nontransgenic mdx littermates 8 weeks after injection of full-length human dystrophin plasmid. (a) and (b) represent two separate experiments. Each bar represents the mean 7 s.e.m. Experiment 1: transgenic n ¼ 10, mdx n ¼ 13. Experiment 2: transgenic n ¼ 5, mdx n ¼ 5. In both experiments, there are significantly more dystrophin-positive fibres in the transgenics compared to mdx littermates. (c) shows a repr esentative Western blot from experiment 2, serum from mdx littermates treated with human dystrophin plasmid exhibit a dystrophin-specific antibody response, whereas serum from similarly treated microdystrop hin transgenic mice show no such response. 6C5 is the contro l antidystrophin monoclonal antibody Dy8/6C5. Blots were simultaneously probed with a monoclonal antibody recognizing metavinculin and vinculin as a loading control. Long-term expression of full-length human dystrophin in mdx mice A Ferrer et al which is able to achieve higher transfection efficiencies in muscle with a single dose of plasmid DNA 20,25 than previously obtained with three doses of naked plasmid DNA directly injected into the muscle. 18 Using the antibody DysC3750 that recognizes both human and murine dystrophin, we assessed the max- imum number of dystrophin-transfected fibr es present in the T A muscles from mdx mice electroporated with the human and murine plasmids. Control experiments showed that there was no increase in the number of revertant fibr es due to the electrotransfer protocol. Thus we could analyse the number of transfected fibres by subtracting the number of revertant fibres in the uninjected leg from the number of dystrophin-positive fibres in the injected leg. As previously observed, a strong immune response was triggered against human full-length dystrophin in the mdx mouse. Despite the high number of transfected fibres present in the muscle 1 week postelectrotransfer , most fibres wer e eliminated by CD8 þ infiltrate observed at this later time point. However , despite the higher level of murine dystro- phin-transfected fibres achieved with electroporation and the possible expression of dystrophin in professional APC, the mdx mouse was again shown to be tolerant to reco mbinant full- length mu rine dys trophi n. In addition to the presence of similar numbers of transfected fibres at both 1 and 8 weeks, there was no evidence of immune rejection as shown by the lack of specific antibodies to murine dystrophin or the presence of a specific CD8 þ T cells infiltrate in the vicinity of murine dystrophin fibres. However , one mouse did have very few transfected fibres at the 8 week time point and there was a small cluster of CD8 þ T cells surrounding a group of dystrophin-expressing fibres, suggesting that tolerance was broken in this individual animal. This individual was probably responsible for the low-level antibody response seen in the pooled sera from this experiment (Figure 4c). Other groups have reported immune r esponses to murine dystrophin. A decrease in the number of dystrophin-positive fibres 6 weeks after coisogenic surrounding dystrophin-positive fibres were noted, together with a CTL response in vitro against C57Bl10 and murine full-length dystrophin transgenic mdx myoblasts. 38 Myoblast transplantation may involve the presentation of other unfamiliar proteins apart from dystrophin as a result of strain divergence and culture conditions that could contribute to the rejection. How- ever , rejection was avoided by intravenous administra- tion of dystrophin MHCI-specific immunogenic peptides 2 weeks prior to transplantation. Recently , Gilchrist et al 39 have shown a decrease in murine dystrophin expression levels 8 weeks after adenovirus delivery of murine full- length dystr ophin, together with the presence of anti- bodies against murine dystrophin and a CD4 þ and CD8 þ T -cell infiltrate in the treated tissue. It is difficult to correlate the dystrophin expression levels reported with the number of dystrophin-positive fibres obtained in our study , but it is possible that tolerance was broken due to the greater antigen load achieved with adenovirus the adenoviral vehicle may have acted as an adjuvant, enhancing the immune r esponse to the transgene. W e believe that the tolerance we observe to murine dystrophin is due to the pres ence of revertant fibres and other dystrophin isoforms in the absence of the endo- genous full-length protein. The expression of dystrophin epitopes developmentally would have ensured that immunoreactive T cells were deleted in the thymus. Each cluster of revertant fibres appears to undergo a specific exon-skipping event and so each cluster ex- presses a diff erent internally deleted dystrophin at their sarcolemma. 6 The mutation in the mdx mice is in exon 23 so it does not affect the production of dystrophin isoforms apart from the 427 kDa full-length protein. It is possible that the smaller isoforms give rise to tolerance to the epitopes present in the second half of the rod domain and the carboxyl-terminus, whereas revertant fibres are the only source of the amino-terminus and the first half of the rod domain epitopes of dystrophin. The mdx3cv mouse displays revertant fibres although 26 However , the promoters for all the dystrophin isoforms ar e present upstream of the site of mutation and so the mdx3cv is not capable of producing any of the smaller dystrophin isoforms, unlike the mdx mouse. After injection with murine full-length dystr ophin plasmid, these mice are also tolerant to the recombinant murine dystrophin as there is no significant decrease in the number of dystrophin-transfected fibres from 1 to 8 weeks. Since the presence of revertant fibres in the mdx provides tolerance to murine dystrophin following gene transfer , we would predict that for many DMD patients the presence of revertant fibres would similarly prevent the elimination of transfected fibres. In a study per- formed by V oit et al , 40 up to 30% of DMD patients had some dystrophin expression as detected by W estern blots and immunohistochemistry . Other groups have also reported the incidence of revertant fibres in 35–70% of DMD patients. 41–43 However , the range of dystrophin epitopes expressed in patient revertant fibres is dependent on the nature and position of the mutation in the dystrophin gene. In order to investigate which regions of the dystrophin molecule are required to provide tolerance to de novo expression of full-length dystrophin, we have investigated the transfer of full-length human dystrophin plasmid into mdx transgenic lines expressing internally deleted recombi- nant dystrophins. These transgenic lines are similar to BMD patients or DMD patients in whom there are lar ge numbers of revertant fibres with exon-skipping events, resulting in the expression of less than 55% of the dystrophin molecule. T olerance was seen in most mice when full-length dystrophin was injected into the human minidystrophin transgenic mice (AB2). This was interesting, as these mice had only 55% of the coding region. However , two mice in this study showed isolated clusters of CD8 þ cells around dystrophin-positive fibres and one of them also had very few transfected fibres, which may be a sign of incomplete tolerance. It is important to note that this experiment involved the induction of muscle regenera- tion by injection of a myotoxic agent in order to increase the efficiency of plasmid delivery by direct injection. Thus the mode of treatment and gene delivery may have contributed to the breakage of tolerance compared to the results observed in the micro-dystrophin experiments. Unfortunately it was not possible to perform the Long-term expression of full-length human dystrophin in mdx mice A Ferrer et al 889 Gene Therapy electrotransfer experiments with the minidystrophin line. At the 8 week time point, a high number of intact dystrophin-transfected fibres wer e pres ent in the muscles from the microdystrophin transgenic line that expresses only 50% of coding region, whereas nearly all transfected fibres had been eliminated in the mdx littermates (Figure 7a and b). Thus we conclude that the transgenic mice were tolerant to the full-length protein. Using an HLA class I humanized mouse model, an HLA-A*0201-restricted immunodominant epitope fro m human dystrophin has been identified. This epitope present in the spectrin-like r epeat 9 of dystrophin is able to elicit CD8 þ CTL responses following intramuscular injection of full-length human dystrophin plasmid. 44 The HLA-A*0201 allele used is expressed in 50% of Cauca- sian human population. Further studies using other HLA alleles will be of great interest in determining the extent of human dystr ophin immune respon ses in the DMD population. W e await publication of the results from the AFM and T ransgene Phase I clinical trial for BMD and DMD. 45 Preliminary reports suggest the absence of adverse side effects including a lack of antidystrophin immune responses. In the mdx mice, at least 5% of the revertant fibres analysed express almost the full-length molecule. 6 A subset of DMD patients pres ent with point mutations (28%) or small deletions (8%), 46 and it is possible that the vast majority of epitopes of the full-length protein will be present in at least some muscle fibres. However , a substantial number of DMD patients (64%) have large genomic deletions and thus any revertant fibre will not express a full range of the epitopes. The location of the mutation in these patients is also of importance, as it will affect the expression of the other isoforms of dystrophin. W e have shown that the expression of a very truncated human dystrophin in transgenic mdx mice prevents the cytotoxic elimination of human full-length dystrophin- transfected fibres, and this suggests that in many cases the presence of revertant fibr es and other isoforms of dystrophin is likely to confer tolerance and prevent serious immune responses in patients undergoing dystrophin gene therapy . Materials and methods Dystrophin plasm ids Plasmids were grown in Escherichia coli XL1-Blue cells (Stratagene, La Jolla, USA) and purified using the Endofree plasmid kit from Qiagen (Crawley , UK). LPS contamination levels in all plasmid prepa rations were less than 0.05 EU per m g of DNA as assessed using Pyrogent 500 turbimetric assay (BioWhittaker , W oking- ham, UK). T wo human dystrophin plasmids utilizing the strong constitutive CMVIE promoter plus intron were used both expressing full-length human dystrophin (CDF and PTG1 1025). CDF (15.6 kb) contains the full- length human dystrophin cDNA and the alternative full-length human dystrophin plasmid; PTG1 1025 (18.8 kb) was kindly supplied by Serge Braun (T rans- gene, Strasbourg, France). 18,19 CDF was used in all the human dystrophin gene transfer studies, except for the experiment with the AB2 transgenic line where PTG1 1025 was used. The murine dystrophin plasmid, CMVmoDys (16.8 kb), contains the full-length murine dystrophin in the same plasmid backbone as CDF except that the SV40 intron associated with the polyadenylation signal sequences was deleted. The murine full-length cDNA was subcloned from CV AA, which was kindly supplied by Jeff Chamberlain. 29 The noncoding plasmid CMV0 was created by the digestion of CMV lacZ (Clontech, BD Biosciences, Oxford, UK) with Not I and Transgenic mou se lines Tw o mdx transgenic lines in which recombinant human dystrophin was driven by the human muscle a -skeletal actin (HSA) pro moter were used in this study . T ransgenic line AB2 ( D 17–48) expresses human minidystrophin with the deletion of exons 17–48. It expresses 20% of endogenous levels of dystrophin at the sarcolemma and these mice show correction of the myopathic phenotype. 27 The microdystrophin transgenic line ( D 13– 48) has a further deletion of three exons in the rod domain. The microdystrophin construct was compiled from PCR-generated fragments in the laboratory of Professor George Dickson and subcloned into the same vector backbone with the HSA promoter as the pre- viously generated transgenic lines. 27 The new transgenic line was generated by standard microinjection proce- dures using C57Bl10 X CBA/CA embryos and transgenic mice crossed onto the mdx background for several 27 Intramuscular injection of plasmid DNA All experiments were carried out with a mix of male and female 6- to 19-week-old mice. Mice were kept in minimal disease facilities with food and water ad libitum . Prior to intramuscular injection, mice were anaesthetized with a mixture of fentanyl/fluanisone and midazolam (Hypnorm, Janssen Animal Health, High W ycombe, UK and Hypnovel, Roche, W elwyn Garden City , UK, respectively). In the minidystrophin (AB2) experiment, direct injec- tion of DNA was carried out in artificially regenerated muscle. At 5 days prior to DNA injection, both T A muscles were treated with 25 m l of an aqueous solution of 1.2% BaCl 2 , a myotoxic agent that induces necrosis and subsequent regeneration of the muscle fibres. 48,49 After 5 days, one T A received a single dose of 50 m g of PTG1 1025 plasmid DNA in 25 m l normal saline, injected percuta- in a proximal to distal direction. In the other experiments, mice under fentanyl/ fluanisone and midazolam anaesthesia were injected with 10 U (25 m l at 0.4 U/ m l) of bovine testes hyaluroni- dase (Sigma, Pool, UK) 2 h prior to DNA injection and electrotransfer . Mice were anaesthetized by inhalation of isofluorane, the DNA injected and an electrical field of 175 V/cm was applied in 10 20-ms squar e wave pulses at 1 Hz using a BTX ECM830 electroporator (VWR Inter- national, Lutterworth, UK) as described in McMahon et al . 25 The left T A received a single dose of 50 m g of dystrophin plasmid DNA in 25 m l normal saline, injected percutaneously using a 27-gauge needle in a proximal to distal direction. The contralateral T A was either left uninjected or injected with the same quantity of CMV0 and served as a control for dystrophin-positive revertant fibres. Long-term expression of full-length human dystrophin in mdx mice A Ferrer et al 890 Gene Therapy Collection of samples Depending on the experiment, samples were colleted at either 1 or 8 weeks after injection of DNA. Under terminal anaesthesia with 0.1 ml pentobarbitol (Euthe- sate, National V et Supplies, Stoke on T rent, UK), mice were subjected to car diac puncture, after which animals were killed by cervical dislocation. The blood was left for a few hours at 4 1 C for the blood clot to retract and it was spun twice at 9000 g for 5 min. For each animal, both T A were excised post-mortem and mounted on cork blocks with a cryoembedding compound (Cryo-M-Bed, Bright, UK). The block was rapidly frozen in isopentane cooled in liquid nitrogen and stored at  70 1 C. Serial sections of 10 m m thickness were cut at 10–12 evenly spaced levels through the block and lifted onto APES-coated glass slides. Dystrophin immunos tains Slides were air-dried, the endogenous biotin blocked using an avidin/biotin blocking system (V ector Labora- tories, Peterborough, UK) and nonspecific binding blocked for 30 min with a 3% solution of dried nonfat milk (Marvel) in PBS/0.05%T ween-20 (PBST). In an initial screen of the microdystrophin transgenic line, sections were stained with either a human dystrophin- specific monoclonal Dy10/12B2 at 1:10 (kindly supplied by Louise Nicholson) or dystrophin rabbit polyclonal DysC3750 at 1:500. 20 For the detection of r evertant fibres or transfected dystrophin-positive fibres above the endogenous transgene expression levels, DysC3750 was titred down to a dilution of 1:2000, a level at which this antibody shows no dystrophin detection in the mini- dystrophin line. 28 Primary antibodies were diluted in PBST plus 1% FCS. Bound antibody was detected with an appropriate biotinylated species specific secondary antibody (Dako, Ely , UK) at 1:500 in PBST , followed by a 30 min incubation with horseradish peroxidase- conjugated streptavidin/biotin complex (ABC-HRP , V ec- tor Laboratories, Peterborough, UK). The enzymatic reaction was visualized by nickel-enhanced diaminoben- zidine solution and slides were dehydrated, cleared with xylene and mounted in DPX (VWR International, Lutterworth, UK). All microscopical analysis was carried out on a Leica DML light microscope and images were r ecorded using an Image Pro-plus package (Datacell, Maidenhead, UK) and a 3CCD colour camera (JVC). Sections from different levels of each muscle were examined and the highest count of dystr ophin-positive fibres was r ecorded both in the control and injected leg and the maximum number of dystrophin-positive revertant fibres in the control leg was subtracted from the total number of dystrophin- positive fibres in the injected leg. Immunohistochemical detection of CD8 þ cells Slides were fixed in acetone for 10 min and nonspecific biotin binding blocked as described above. Sections were incubated with primary antibody rat anti-mouse CD8 (clone no. YTS 169.4, Serotec, Oxford, UK) at 1:500 at room temperature for 1 h. Sections were incubated for an hour with secondary biotinylated rabbit anti-rat antibody (Dako, Ely , UK) at 1:500 in PBST , followed by a 30 min incubation with horseradish peroxidase-conjugated streptavidin/biotin complex (ABC-HRP , Dako, Ely , UK) and the reaction visualized as described above. For quantitation of CD8 þ cells in each sample, the total number of CD8 þ cells was assessed fro m three randomly selected fields from the cross-sectional area showing the highest degree of infiltrate. The three microscopic fields at a magnification of  100 were captured to a computer using a JVC Ky-F55B 3-CCD camera. The pixel area of dark br own DAB precipitate above a fixed colour threshold was analysed using the SigmaScan Pro version 5.0.0 image analysis software (SPSS, Birmingham, UK). A linear regression curve of the number of manually counted CD8 þ cells versus the pixel area they occupy in the microscopic field was obtained for each experiment ( r 2 ¼ 0.81–0.95). For each sample, the average number of CD8 þ cells per random field was extrapolated from the standard curve and expressed as the number of CD8 þ cells per mm 2 . The results are presented as the increa sed number of CD8 þ cells in the treated muscle compared to the untreated muscle, thus demonstrating possible specific increases above the Western blot analysis of humoral immune response Skeletal muscle fro m C57BL10, mdx, minidystrophin, microdystrophin and AD17 (a transgenic mouse line that overexpresses full-length human dystrophin) 27 was ground to a powder in liquid nitrogen and resuspended in T ris-buffered saline with 1% NP40, 0.5%. sodium deoxycholate, 0.1% SDS and protease inhibitors (RIP A buffer 29 ). After a 5 min centrifugation at 13 000 rpm in a bench centrifuge to pellet myofilaments, the super- natants were solubilized in 10% SDS sample buffer and fractionated on a 6% polyacrylamide gel as described previously . 27,28 Proteins wer e transferred to PVDF mem- brane and equality of protein transfer confirmed by staining the membrane with a 0.1% solution of amido black. For the analysis of humoral immune respon ses, strips of membrane from blots containing pair ed tracks were prepared. Methanol prewetted membranes were incubated with a 5% solution of dried milk (Marvel) in TBS containing 0.05% of T ween-20 (TBST) prior to incubation with either control dystrophin monoclonal antibody Dy8/6C5 (a kind gift fr om Louise Nicholson, Newcastle, UK) at 1/100 dilution in TBST or 1/20 dilution of mouse serum in 2% Marvel in TBST . All strips wer e simultaneously probed with a monoclonal antibody against vinculin at 1/400 dilution in TBST (V9131, Sigma, Poole, UK). This was chosen as the loading control as vinculin occupies a subsarcolemmal position similar to dystrophin. Secondary antibody goat anti-mouse IgG conjugated to HRP (Biorad, Hertford- shire, UK) was used at a dilution of 1:10 000. Antibodies were detected by enhanced chemiluminescence (ECL; Amersham Biosciences, Chalfont St Giles, UK). The blots were exposed to blue sensitive X-ray film (GRI, Braintree, UK) and developed using an Automatic X-Ray Film (Processor X-ograph Imaging Systems, Malmesbury , UK). Statistical analysis W ith normally distributed data, statistical analysis was followed by multiple paired comparisons as appropriate. Long-term expression of full-length human dystrophin in mdx mice A Ferrer et al 891 Gene Therapy For nonparametric data, statistical analysis was con- ducted by Mann–Whitney rank-sum test or ANOV A on ranks, followed by multiple paired comparisons as appropriate. Groups were considered statistically sig-
https://www.researchgate.net/publication/7362772_Long-term_expression_of_full-length_human_dystrophin_in_transgenic_mdx_mice_expressing_internally_deleted_human_dystrophins
Intelligent Resource Allocation in Joint Radar-Communication With Graph Neural Networks | Request PDF Request PDF | Intelligent Resource Allocation in Joint Radar-Communication With Graph Neural Networks | Autonomous vehicles produce high data rates of sensory information from sensing systems. To achieve the advantages of sensor fusion among... | Find, read and cite all the research you need on ResearchGate Intelligent Resource Allocation in Joint Radar-Communication With Graph Neural Networks October 2022 IEEE Transactions on Vehicular Technology 71(10):11120-11135 DOI: 10.1109/TVT.2022.3187377 Authors: Dusit Niyato Abstract Autonomous vehicles produce high data rates of sensory information from sensing systems. To achieve the advantages of sensor fusion among different vehicles in a cooperative driving scenario, high data-rate communication becomes essential. Current strategies for joint radar-communication (JRC) often rely on specialized hardware, prior knowledge of the system model, and entail diminished capability in either radar or communication functions. In this paper, we propose a framework for intelligent vehicles to conduct JRC, with minimal prior knowledge of the system model and a tunable performance balance, in an environment where surrounding vehicles execute radar detection periodically, which is typical in contemporary protocols. We introduce a metric on the usefulness of data to help an intelligent vehicle decide what, and to whom, data should be transmitted. The problem framework is cast as a generalized form of the Markov Decision Process (MDP). We identify deep reinforcement learning algorithms (DRL) and algorithmic extensions suitable for solving our JRC problem. For multi-agent scenarios, we introduce a Graph Neural Network (GNN) framework via a control channel. This framework enables modular and fair comparisons of various algorithmic extensions. Our experiments show that DRL results in superior performance compared to non-learning algorithms. Learning of inter-agent coordination in the GNN framework, based only on the Markov task reward, further improves performance. Article Full-text available Feb 2022 ARTIF INTELL REV Sven Gronauer Klaus Dieopold The advances in reinforcement learning have recorded sublime success in various domains. Although the multi-agent domain has been overshadowed by its single-agent counterpart during this progress, multi-agent reinforcement learning gains rapid traction, and the latest accomplishments address problems with real-world complexity. This article provides an overview of the current developments in the field of multi-agent deep reinforcement learning. We focus primarily on literature from recent years that combines deep reinforcement learning methods with a multi-agent scenario. To survey the works that constitute the contemporary landscape, the main contents are divided into three parts. First, we analyze the structure of training schemes that are applied to train multiple agents. Second, we consider the emergent patterns of agent behavior in cooperative, competitive and mixed scenarios. Third, we systematically enumerate challenges that exclusively arise in the multi-agent domain and review methods that are leveraged to cope with these challenges. To conclude this survey, we discuss advances, identify trends, and outline possible directions for future work in this research area. Article Full-text available Oct 2020 IEEE NETWORK Helin Yang Zehui Xiong With the rapid development of smart terminals and infrastructures, as well as diversified applications (e.g., virtual and augmented reality, remote surgery and holographic projection) with colorful requirements, current networks (e.g., 4G and upcoming 5G networks) may not be able to completely meet quickly rising traffic demands. Accordingly, efforts from both industry and academia have already been put to the research on 6G networks. Recently, artificial intelligence (AI) has been utilized as a new paradigm for the design and optimization of 6G networks with a high level of intelligence. Therefore, this article proposes an AI-enabled intelligent architecture for 6G networks to realize knowledge discovery, smart resource management, automatic network adjustment and intelligent service provisioning, where the architecture is divided into four layers: intelligent sensing layer, data mining and analytics layer, intelligent control layer and smart application layer. We then review and discuss the applications of AI techniques for 6G networks and elaborate how to employ the AI techniques to efficiently and effectively optimize the network performance, including AI-empowered mobile edge computing, intelligent mobility and handover management, and smart spectrum management. We highlight important future research directions and potential solutions for AI-enabled intelligent 6G networks, including computation efficiency, algorithms robustness, hardware development and energy management. Conference Paper Full-text available Jul 2020 Dimitris Giouroukis Alexander Dadiani Jonas Traub Volker Markl The Internet of Things (IoT) represents one of the fastest emerging trends in the area of information and communication technology. The main challenge in the IoT is the timely gathering of data streams from potentially millions of sensors. In particular, those sensors are widely distributed, constantly in transit, highly heterogeneous,and unreliable. To gather data in such a dynamic environment efficiently, two techniques have emerged over the last decade: adaptive sampling and adaptive filtering. These techniques dynamically re-configure rates and filter thresholds to trade-off data quality against resource utilization. In this paper, we survey representative, state-of-the-art algorithms to address scalability challenges in real-time and distributed sensor systems. To this end, we cover publications from top peer-reviewed venues for a period larger than 12 years. For each algorithm, we point out advantages, disadvantages, assumptions, and limitations. Furthermore, we outline current research challenges, future research directions, and aim to support readers in their decision process when designing extremely distributed sensor systems. Article Full-text available Oct 2019 CHINA COMMUN Jingxuan Huang Zesong Fei Tianxiong Wang Guohua Wei With the development of automated driving vehicles, more and more vehicles will be fitted with more than one automotive radars, and the radar mutual interference will become very significant. Vehicle to everything (V2X) communication is a potential way for coordinating automotive radars and reduce the mutual interference. In this paper, we analyze the positional relation of the two radars that interfere with each other, and evaluate the mutual interference for different types of automotive radars based on Poisson point process (PPP). We also propose a centralized framework and the corresponding algorithm, which relies on V2X communication systems to allocate the spectrum resources for automotive radars to minimize the interference. The minimum spectrum resources required for zero-interference are analyzed for different cases. Simulation results validate the analysis and show that the proposed framework can achieve near-zero-interference with the minimum spectrum resources. Joint Radar and Communication Design: Applications, State-of-the-Art, and the Road Ahead Article Full-text available Feb 2020 IEEE T COMMUN Fan Liu Christos Masouros Athina Petropulu L. Hanzo Sharing of the frequency bands between radar and communication systems has attracted substantial attention, as it can avoid under-utilization of otherwise permanently allocated spectral resources, thus improving efficiency. Further, there is increasing demand for radar and communication systems that share the hardware platform as well as the frequency band, as this not only decongests the spectrum, but also benefits both sensing and signaling operations via the full cooperation between both functionalities. Nevertheless, its success critically hinges on high-quality joint radar and communication designs. In the first part of this paper, we overview the research progress in the areas of radar-communication coexistence and dual-functional radar-communication (DFRC) systems, with particular emphasis on the application scenarios and the technical approaches. In the second part, we propose a novel transceiver architecture and frame structure for a DFRC base station (BS) operating in the millimeter wave (mmWave) band, using the hybrid analog- digital (HAD) beamforming technique. We assume that the BS is serving a multi-antenna user equipment (UE) over a mmWave channel, and at the same time it actively detects targets. The targets also play the role of scatterers for the communication signal. In that framework, we propose a novel scheme for joint target search and communication channel estimation relying on omni-directional pilot signals generated by the HAD structure. Given a fully-digital communication precoder and a desired radar transmit beampattern, we propose to design the analog and digital precoders under non-convex constant-modulus (CM) and power constraints, such that the BS can formulate narrow beams towards all the targets, while pre-equalizing the impact of the communication channel. Furthermore, we design a HAD receiver that can simultaneously process signals from the UE and echo waves from the targets. By tracking the angular variation of the targets, we show that it is possible to recover the target echoes and mitigate its potential interference imposed on the UE signals, even when the radar and communication signals share the equivalent signal-to-noise ratio (SNR). The feasibility and the efficiency of the proposed approaches in realizing DFRC are verified via numerical simulations. Finally, our discussions are summarized by overviewing the open problems in the research field of communication and radar spectrum sharing (CRSS). <br/ Deep Reinforcement Learning for 5G Networks: Joint Beamforming, Power Control, and Interference Coordination Article Full-text available Mar 2020 IEEE T COMMUN Faris B. Mismar Brian L. Evans Ahmed Alkhateeb The fifth generation of wireless communications (5G) promises massive increases in traffic volume and data rates, as well as improved reliability in voice calls. Jointly optimizing beamforming, power control, and interference coordination in a 5G wireless network to enhance the communication performance to end users poses a significant challenge. In this paper, we formulate the joint design of beamforming, power control, and interference coordination as a non-convex optimization problem to maximize the signal to interference plus noise ratio (SINR) and solve this problem using deep reinforcement learning. By using the greedy nature of deep Q-learning to estimate future rewards of actions and using the reported coordinates of the users served by the network, we propose an algorithm for voice bearers and data bearers in sub-6 GHz and millimeter wave (mmWave) frequency bands, respectively. The algorithm improves the performance measured by SINR and sum-rate capacity. In realistic cellular environments, the simulation results show that our algorithm outperforms the link adaptation industry standards for sub-6 GHz voice bearers. For data bearers in the mmWave frequency band, our algorithm approaches the maximum sum rate capacity, but with less than 4% of the required run time. Deep Learning Coordinated Beamforming for Highly-Mobile Millimeter Wave Systems Article Full-text available Jun 2018 Ahmed Alkhateeb Sam Alex Paul Varkey Djordje Tujkovic Supporting high mobility in millimeter wave (mmWave) systems enables a wide range of important applications such as vehicular communications and wireless virtual/augmented reality. Realizing this in practice, though, requires overcoming several challenges. First, the use of narrow beams and the sensitivity of mmWave signals to blockage greatly impact the coverage and reliability of highly-mobile links. Second, highly-mobile users in dense mmWave deployments need to frequently hand-off between base stations (BSs), which is associated with critical control and latency overhead. Further, identifying the optimal beamforming vectors in large antenna array mmWave systems requires considerable training overhead, which significantly affects the efficiency of these mobile systems. In this paper, a novel integrated machine learning and coordinated beamforming solution is developed to overcome these challenges and enable highly-mobile mmWave applications. In the proposed solution, a number of distributed yet coordinating BSs simultaneously serve a mobile user. This user ideally needs to transmit only one uplink training pilot sequence that will be jointly received at the coordinating BSs using omni or quasi-omni beam patterns. These received signals draw a defining signature not only for the user location, but also for its interaction with the surrounding environment. The developed solution then leverages a deep learning model that learns how to use these signatures to predict the beamforming vectors at the BSs. This renders a comprehensive solution that supports highly-mobile mmWave applications with reliable coverage, low latency, and negligible training overhead. Extensive simulation results, based on accurate ray-tracing, show that the proposed deep-learning coordinated beamforming strategy approaches the achievable rate of the genie-aided solution that knows the optimal beamforming vectors with no training overhead. Compared to traditional beamforming solutions, the results show that the proposed deep learning based strategy attains higher rates, especially in high-mobility large-array regimes. Toward Intelligent Vehicular Networks: A Machine Learning Framework Article Full-text available Apr 2018 Le Liang Hao Ye Geoffrey Li As wireless networks evolve towards high mobility and providing better support for connected vehicles, a number of new challenges arise due to the resulting high dynamics in vehicular environments and thus motive rethinking of traditional wireless design methodologies. Future intelligent vehicles, which are at the heart of high mobility networks, are increasingly equipped with multiple advanced onboard sensors and keep generating large volumes of data. Machine learning, as an effective approach to artificial intelligence, can provide a rich set of tools to exploit such data for the benefit of the networks. In this article, we first identify the distinctive characteristics of high mobility vehicular networks and motivate the use of machine learning to address the resulting challenges. After a brief introduction of the major concepts of machine learning, we discuss its applications to learn the dynamics of vehicular networks and make informed decisions to optimize network performance. In particular, we discuss in greater detail the application of reinforcement learning in managing network resources as an alternative to the prevalent optimization approach. Finally, some open issues worth further investigation are highlighted. Scheduling Algorithms for Minimizing Age of Information in Wireless Broadcast Networks with Random Arrivals Article Full-text available Dec 2017 IEEE T MOBILE COMPUT yu-Pin Hsu Lingjie Duan Eytan Modiano Age of information is a newly proposed metric that captures packet delay to end-users from an application layer perspective. The age measures the amount of time that elapsed since the latest information was generated at a source. In this context, we study an age minimisation problem over a broadcast network to keep many users updated on timely information, where only one user can be served at a time. We formulate a Markov decision process (MDP) to find dynamic scheduling algorithms, with the purpose of minimizing the long-run average age. We show that an optimal scheduling algorithm for the MDP is a simple stationary switch-type. However, the optimal scheduling algorithm is not easy to implement due to the MDP's infinite state-space. Using a sequence of finite-state approximate MDPs, we successfully develop both optimal off-line and on-line scheduling algorithms. We validate the algorithms via numerical studies, and surprisingly show that the performance of no-buffer networks is very close to that of networks with buffers. Next Generation Radar Sensors in Automotive Sensor Fusion Systems Conference Paper Full-text available Oct 2017 Josef Steinbaeck Christian Steger Gerald Holweg Norbert Druml During the last decades, radar sensors have become an established component in assisted driving systems. Light detection and ranging (LIDAR) sensors are commonly perceived as the key technology to enable fully autonomous driving, but are still expensive. Recent advances in radar technology, enable modern radar sensors to sense the environment in higher detail, thus adding significant value to the environment perception quality of a sensor fusion system. Due to their performance, reliability, and cost-efficiency, modern radar sensors will be a crucial element in future autonomous vehicles. In this paper we give an overview of the current state-of-the-art of automotive radar sensors and their potential in future vehicles and data fusion systems. We want to show that modern radar sensors add significant value to automotive environment perception in order to enable fully automated driving. Additionally , challenges arising with the integration of new radar sensors and remaining issues are discussed. View Real-time Sampling Rate Adaptation based on Continuous Risk Level Evaluation in Wireless Body Sensor Networks Conference Paper Full-text available Oct 2017 Carol Habib Abdallah Makhoul Rony Darazi Raphaël Couturier Wireless Body Sensor Networks (WBSNs) are a low-cost solution allowing remote patient monitoring and continuous health assessment, thus reducing healthcare expenditure. In such networks, sensor nodes periodically collect vital signs and send them to the coordinator for fusion. However, sensor nodes have limited energy and processing resources and transmission is the most power-hungry task. In this paper, we target data reduction and energy consumption. We propose to locally adapt, in real-time, the sampling rate of a sensor node according to the variations in the vital sign being monitored and its risk. We propose to dynamically evaluate, in real-time, the risk of any vital sign given the information about the severity level of the patient's health condition and the severity level of the vital sign itself. We have tested our proposed approach on real health datasets in order to evaluate it. The results show that the percentage of detected critical events and the mean-square error (MSE) are both acceptable. In addition, the percentage of data reduction is around 50% implying a reduction of the energy consumption. Adjusting the risk of a vital sign, over time, ensures the adaptation of the sampling rate according to the overall health condition of the patient as well as the severity level of the collected measurements. Learning to Communicate with Deep Multi-Agent Reinforcement Learning Article Full-text available May 2016 Jakob Foerster Yannis Assael Nando de Freitas Shimon Whiteson We consider the problem of multiple agents sensing and acting in environments with the goal of maximising their shared utility. In these environments, agents must learn communication protocols in order to share information that is needed to solve the tasks. By embracing deep neural networks, we are able to demonstrate end-to-end learning of protocols in complex environments inspired by communication riddles and multi-agent computer vision problems with partial observability. We propose two approaches for learning in these domains: Reinforced Inter-Agent Learning (RIAL) and Differentiable Inter-Agent Learning (DIAL). The former uses deep Q-learning, while the latter exploits the fact that, during learning, agents can propagate error derivatives through (noisy) communication channels. Hence, this approach uses centralised learning but decentralised execution. Our experiments introduce new environments for studying the learning of communication protocols and present a set of engineering innovations that are essential for success in these domains. View Show abstract Asynchronous Methods for Deep Reinforcement Learning Article Full-text available Feb 2016 Volodymyr Mnih Adrià Puigdomènech Badia Mehdi Mirza Koray Kavukcuoglu We propose a conceptually simple and lightweight framework for deep reinforcement learning that uses asynchronous gradient descent for optimization of deep neural network controllers. We present asynchronous variants of four standard reinforcement learning algorithms and show that parallel actor-learners have a stabilizing effect on training allowing all four methods to successfully train neural network controllers. The best performing method, an asynchronous variant of actor-critic, surpasses the current state-of-the-art on the Atari domain while training for half the time on a single multi-core CPU instead of a GPU. Furthermore, we show that asynchronous actor-critic succeeds on a wide variety of continuous motor control problems as well as on a new task involving finding rewards in random 3D mazes using a visual input. Making Bertha See Even More: Radar Contribution Article Full-text available Jan 2015 Juergen Dickmann Nils Appenrodt Jens Klappstein Carsten Brenk For decades, radar has been applied extensively in warfare, earth observation, rain detection, and industrial applications. All those areas are characterized by requirements such as high quality of service, reliability, robustness in harsh environment and short update time for environmental perception, and even imaging tasks. In the vehicle safety and driver assistance field, radars have found widespread application globally in nearly all vehicle brands. With the market introduction of the 2014 Mercedes-Benz S-Class vehicle equipped with six radar sensors covering the vehicles environment 360° in the near (up to 40 m) and far range (up to 200 m), autonomous driving has become a reality even in low-speed highway scenarios. A large azimuth field of view, multimodality and a high update rate have been the key innovations on the radar side. One major step toward autonomous driving was made in August 2013. A Mercedes-Benz research S-Class vehicle—referred to at Mercedes as Bertha—drove completely autonomously for about 100 km from Mannheim to Pforzheim, Germany. It followed the well-known historic Bertha Benz Memorial Route. This was done on the basis of one stereo vision system, comprising several long and short range radar sensors. These radars have been modified in Doppler resolution and dramatically improved in their perception capabilities. The new algorithms consider that urban scenarios are characterized by significantly shorter reaction and observation times, shorter mean free distances, a 360° interaction zone, and a large variety of object types to be considered. This paper describes the main challenges that Daimler radar researchers faced and their solutions to make Bertha see. A Survey on Platoon-Based Vehicular Cyber-Physical Systems Article Full-text available Mar 2015 Dongyao(Tony) Jia Kejie Lu Jianping Wang Xuemin Sherman Shen Vehicles on the road with some common interests can cooperatively form a platoon-based driving pattern, in which a vehicle follows another one and maintains a small and nearly constant distance to the preceding vehicle. It has been proved that, compared to driving individually, such a platoon-based driving pattern can significantly improve the road capacity and energy efficiency. Moreover, with the emerging vehicular adhoc network (VANET), the performance of platoon in terms of road capacity, safety and energy efficiency, etc., can be further improved. On the other hand, the physical dynamics of vehicles inside the platoon can also affect the performance of VANET. Such a complex system can be considered as a platoon-based vehicular cyber-physical system (VCPS), which has attracted significant attention recently. In this paper, we present a comprehensive survey on platoon-based VCPS. We first review the related work of platoon-based VCPS. We then introduce two elementary techniques involved in platoon-based VCPS: the vehicular networking architecture and standards, and traffic dynamics, respectively. We further discuss the fundamental issues in platoon-based VCPS, including vehicle platooning/clustering, cooperative adaptive cruise control (CACC), platoon-based vehicular communications, etc., and all of which are characterized by the tight coupled relationship between traffic dynamics and VANET behaviors. Since system verification is critical to VCPS development, we also give an overview of VCPS simulation tools. Finally, we share our view on some open issues that may lead to new research directions. Millimeter Wave Mobile Communications for 5G Cellular: It Will Work! Article Full-text available Jan 2013 Shu Sun Rimma Mayzus Felix Gutierrez T.S. Rappaport The global bandwidth shortage facing wireless carriers has motivated the exploration of the underutilized millimeter wave (mm-wave) frequency spectrum for future broadband cellular communication networks. There is, however, little knowledge about cellular mm-wave propagation in densely populated indoor and outdoor environments. Obtaining this information is vital for the design and operation of future fifth generation cellular networks that use the mm-wave spectrum. In this paper, we present the motivation for new mm-wave cellular systems, methodology, and hardware for measurements and offer a variety of measurement results that show 28 and 38 GHz frequencies can be used when employing steerable directional antennas at base stations and mobile devices. Real-time status: How often should one update? Article Full-text available Mar 2012 Roy Yates Sanjit Kaul Marco Gruteser Increasingly ubiquitous communication networks and connectivity via portable devices have engendered a host of applications in which sources, for example people and environmental sensors, send updates of their status to interested recipients. These applications desire status updates at the recipients to be as timely as possible; however, this is typically constrained by limited network resources. In this paper, we employ a time-average age metric for the performance evaluation of status update systems. We derive general methods for calculating the age metric that can be applied to a broad class of service systems. We apply these methods to queue-theoretic system abstractions consisting of a source, a service facility and monitors, with the model of the service facility (physical constraints) a given. The queue discipline of first-come-first-served (FCFS) is explored. We show the existence of an optimal rate at which a source must generate its information to keep its status as timely as possible at all its monitors. This rate differs from those that maximize utilization (throughput) or minimize status packet delivery delay. While our abstractions are simpler than their real-world counterparts, the insights obtained, we believe, are a useful starting point in understanding and designing systems that support real time status updates. Minimizing age of information in vehicular networks Conference Paper Full-text available Jun 2011 Sanjit Kaul Marco Gruteser Vinuth Rai John B. Kenney Emerging applications rely on wireless broadcast to disseminate time-critical information. For example, vehicular networks may exchange vehicle position and velocity information to enable safety applications. The number of nodes in one-hop communication range in such networks can be very large, leading to congestion and undesirable levels of packet collisions. Earlier work has examined such broadcasting protocols primarily from a MAC perspective and focused on selective aspects such as packet error rate. In this work, we propose a more comprehensive metric, the average system information age, which captures the requirement of such applications to maintain current state information from all other nearby nodes. We show that information age is minimized at an optimal operating point that lies between the extremes of maximum throughput and minimum delay. Further, while age can be minimized by saturating the MAC and setting the CW size to its throughput-optimal value, the same cannot be achieved without changes in existing hardware. Also, via simulations we show that simple contention window size adaptations like increasing or decreasing the window size are unsuitable for reducing age. This motivates our design of an application-layer broadcast rate adaptation algorithm. It uses local decisions at nodes in the network to adapt their messaging rate to keep the system age to a minimum. Our simulations and experiments with 300 ORBIT nodes show that the algorithm effectively adapts the messaging rates and minimizes the system age. Stable-Baselines3: Reliable Reinforcement Learning Implementations Article Jan 2021 J MACH LEARN RES Antonin Raffin Ashley Hill Adam Gleave Noah Dormann Stable-Baselines3 provides open-source implementations of deep reinforcement learning (RL) algorithms in Python. The implementations have been benchmarked against reference codebases, and automated unit tests cover 95% of the code. The algorithms follow a consistent interface and are accompanied by extensive documentation, making it simple to train and compare different RL algorithms. Our documentation, examples, and source-code are available at https://github.com/DLR-RM/stable-baselines3. Learning to Schedule Joint Radar-Communication With Deep Multi-Agent Reinforcement Learning Article Nov 2021 IEEE T VEH TECHNOL Tao Dusit Niyato Joash Lee Yong Liang Guan Dong In Kim Radar detection and communication are two of several sub-tasks essential for the operation of next-generation autonomous vehicles (AVs). The former is required for sensing and perception, more frequently so under various unfavorable environmental conditions such as heavy precipitation; the latter is needed to transmit time-critical data. Forthcoming proliferation of faster 5G networks utilizing mmWave is likely to lead to interference with automotive radar sensors, which has led to a body of research on the development of Joint Radar Communication (JRC) systems and solutions. This paper considers the problem of time-sharing for JRC, with the additional simultaneous objective of minimizing the average age of information (AoI) transmitted by a JRC-equipped AV. We first formulate the problem as a Markov Decision Process (MDP). We then propose a more general multi-agent system, with an appropriate medium access control protocol (MAC), which is formulated as a partially observed Markov game (POMG). To solve the POMG, we propose a multi-agent extension of the Proximal Policy Optimization (PPO) algorithm, along with algorithmic features to enhance learning from raw observations. Simulations are run with a range of environmental parameters to mimic variations in real-world operation. The results show that the chosen deep reinforcement learning methods allow the agents to obtain good results with minimal a priori knowledge about the environment. Learning to Schedule Joint Radar-Communication Requests for Optimal Information Freshness Conference Paper Jul 2021 Joash Lee Yong Liang Guan Dusit Niyato Dong In Kim Adaptive Scheduling for Joint CommRadar: Optimizing Tradeoff Among Data Throughput, Queueing Delay, and Detection Opportunities Conference Paper Apr 2021 Honghao Ju Yan Long Xuming Fang Rong He Kalman Filtering With Adaptive Step Size Using a Covariance-Based Criterion Article Mar 2021 IEEE T INSTRUM MEAS Barak Or Ben-Zion Bobrovsky Itzik Klein In Kalman filtering, a trade-off exists when selecting the filter step size. Generally, a smaller step size improves the estimation accuracy, yet with the cost of a high computational load. To mitigate this trade-off influence on performance, a criterion that acts as a guideline for a reasonable choice of the step size is proposed. This criterion is based on the predictor-corrector error covariance matrices of the discrete Kalman filter. In addition, this criterion is elaborated to an adaptive algorithm, for the case of the time-varying measurement noise covariance. Two simulation examples and a field experiment using a quadcopter are presented and analyzed to show the benefits of the proposed approach. Queue-Aware Dynamic Resource Allocation for the Joint Communication-Radar System Article Dec 2020 IEEE T VEH TECHNOL Heng Yang Zhiqing Wei Zhiyong Feng Ping Zhang The joint communication-radar system (JCRS) is promising in the future wireless network which can provide great advantages, such as structure simplification, interference mitigation and less resource occupation, compared with the traditional separate deployment of communication and radar systems. However, with the large number of users accessing the network both for communication and radar purposes, massive user data packets may arrive at the base station equipped with the JCRS in a short period of time, which can easily cause the backlog of user data packets and affect network stability. To solve this problem, we introduce orthogonal frequency division multiple access (OFDMA) technique into the JCRS to support communication function for massive users. Then, we design a queue scheduling model of user data packets to perceive the status of current queue backlog and schedule the queue dynamically. Different from the existing works, we formulate a transmit power minimization problem, while taking network stability and radar detection performance into account. Since the problem is a non-convex problem, we transform it into the upper-bound minimization of drift-plus-function by using the Lyapunov optimization technique. Further, the successive convex approximation method and parameter transformation method are exploited to convert this problem into a convex problem. Finally, we derive an optimal closed-form power allocation expression by using the Lagrangian dual decomposition method and propose a dynamic subcarrier and power allocation algorithm. Simulation results show that the proposed algorithm can achieve an $[{\rm {O}}(1/\eta),{\rm {O}}(\eta)]$ power-backlog tradeoff and demonstrate the efficacy of the proposed algorithm in reducing transmit power while significantly enhancing network stability. Joint Bi-Static Radar and Communications Designs for Intelligent Transportation Article Aug 2020 IEEE T VEH TECHNOL Ning Cao Yunfei Chen Xueyun Gu Wei Feng The cooperation of radar and communications becomes important in vehicular environments due to the demand for radar-assisted communications or communications-assisted radar. In this paper, the tradeoff between bi-static radar and communications in a joint radar-communications setting is studied. We propose three schemes by using time division, superposition or their mixture. For each scheme, three optimization problems are formulated to maximize either the probability of detection for radar subject to a minimum communications rate, the communications rate subject to a minimum probability of detection for radar, or a combined measure of tradeoff. Specifically, given a fixed amount of total time or power for both communications and radar, the optimal power allocation and/or time allocation between radar and communications are derived. Numerical results show that the superposition scheme outperforms the time division scheme and the mixture scheme with considerable performance gains. They also show that the surveillance channel in radar and the communications channel are more important than the direct channel in radar. iRDRC: An Intelligent Real-Time Dual-Functional Radar-Communication System for Automotive Vehicles Article Aug 2020 Nguyen Quang Hieu Dusit Niyato Hoang Dinh Thai Cong Luong Nguyen This letter introduces an intelligent Real-time Dual-functional Radar-Communication (iRDRC) system for autonomous vehicles (AVs). This system enables an AV to perform both radar and data communications functions to maximize bandwidth utilization as well as significantly enhance safety. In particular, the data communications function allows the AV to transmit data, e.g., of current traffic, to edge computing systems and the radar function is used to enhance the reliability and reduce the collision risks of the AV, e.g., under bad weather conditions. The problem of the iRDRC is to decide when to use the communication mode or the radar mode to maximize the data throughput while minimizing the miss detection probability of unexpected events given the uncertainty of surrounding environment. To solve the problem, we develop a deep reinforcement learning algorithm that allows the AV to quickly obtain the optimal policy without requiring any prior information about the environment. Simulation results show that the proposed scheme outperforms baseline schemes in terms of data throughput, miss detection probability, and convergence rate. Transparent Glass Antenna for 28 GHz and its Signal Reception Characteristics in Urban Environment Conference Paper Mar 2020 Minoru Inomata Toshiki Sayama Takeshi Motegi Kiyoshi Nobuoka Joint Radar-Communication Strategies for Autonomous Vehicles: Combining Two Key Automotive Technologies Article Jul 2020 Dingyou Ma Nir Shlezinger Tianyao Huang Yonina Eldar Self-driving cars constantly assess their environment to choose routes, comply with traffic regulations, and avoid hazards. To that aim, such vehicles are equipped with wireless communications transceivers as well as multiple sensors, including automotive radars. The fact that autonomous vehicles implement both radar and communications motivates designing these functionalities in a joint manner. Such dualfunction radar-communications (DFRC) designs are the focus of a large body of recent work. These approaches can lead to substantial gains in size, cost, power consumption, robustness, and performance, especially when both radar and communications operate in the same range, which is the case in vehicular applications. Multi-Agent Game Abstraction via Graph Attention Neural Network Article Apr 2020 Lucas Liu Weixun Wang Yujing Hu Yang Gao In large-scale multi-agent systems, the large number of agents and complex game relationship cause great difficulty for policy learning. Therefore, simplifying the learning process is an important research issue. In many multi-agent systems, the interactions between agents often happen locally, which means that agents neither need to coordinate with all other agents nor need to coordinate with others all the time. Traditional methods attempt to use pre-defined rules to capture the interaction relationship between agents. However, the methods cannot be directly used in a large-scale environment due to the difficulty of transforming the complex interactions between agents into rules. In this paper, we model the relationship between agents by a complete graph and propose a novel game abstraction mechanism based on two-stage attention network (G2ANet), which can indicate whether there is an interaction between two agents and the importance of the interaction. We integrate this detection mechanism into graph neural network-based multi-agent reinforcement learning for conducting game abstraction and propose two novel learning algorithms GA-Comm and GA-AC. We conduct experiments in Traffic Junction and Predator-Prey. The results indicate that the proposed methods can simplify the learning process and meanwhile get better asymptotic performance compared with state-of-the-art algorithms. Space-Domain Index Modulation for MmWave Cloud Radio Access Networks Article Mar 2020 IEEE T VEH TECHNOL Sheng Luo Ping Yang Yueling Che Kaishun Wu In this paper, we investigate the uplink transmission strategy of a cloud radio access network (C-RAN) based millimeter-wave (mmWave) communication system and propose to use a space-domain index modulation (SDIM) scheme to improve the system reliability. The key idea of the proposed SDIM scheme is to enable the user (UE) to use different beam directions to carry part of information. We first introduce the SDIM scheme into C-RAN based mmWave communication system and model the signal design as an optimization problem. Then, two detection methods, namely the centralized detection and distributed detection, are proposed to demodulate the received signal. Moreover, we propose a power allocation algorithm to minimize the system symbol error rate (SER). Following this, by ignoring the side lobe of the UE, the condition which ensures the superiority performance of mmWave SDIM against the conventional communication scheme is derived. Finally, we model the position of the remote radio heads (RHHs) of the network as a homogeneous Poisson point process (PPP) and derive the probability that the proposed SDIM scheme outperforms the conventional communication scheme to evaluate its performance. Analytical and numerical results show that the proposed SDIM scheme can effectively enhance the system reliability. View Show abstract Deep-Learning-Based Wireless Resource Allocation With Application to Vehicular Networks Article Dec 2019 P IEEE Guanding Yu Le Liang Hao Ye Geoffrey Li It has been a long-held belief that judicious resource allocation is critical to mitigating interference, improving network efficiency, and ultimately optimizing wireless communication performance. The traditional wisdom is to explicitly formulate resource allocation as an optimization problem and then exploit mathematical programming to solve the problem to a certain level of optimality. Nonetheless, as wireless networks become increasingly diverse and complex, for example, in the high-mobility vehicular networks, the current design methodologies face significant challenges and thus call for rethinking of the traditional design philosophy. Meanwhile, deep learning, with many success stories in various disciplines, represents a promising alternative due to its remarkable power to leverage data for problem solving. In this article, we discuss the key motivations and roadblocks of using deep learning for wireless resource allocation with application to vehicular networks. We review major recent studies that mobilize the deep-learning philosophy in wireless resource allocation and achieve impressive results. We first discuss deep-learning-assisted optimization for resource allocation. We then highlight the deep reinforcement learning approach to address resource allocation problems that are difficult to handle in the traditional optimization framework. We also identify some research directions that deserve further investigation. Optimizing Information Freshness in Wireless Networks Under General Interference Constraints Article Dec 2019 IEEE ACM T NETWORK Rajat Talak Sertac Karaman Eytan Modiano Age of information (AoI) is a recently proposed metric for measuring information freshness. AoI measures the time that elapsed since the last received update was generated. We consider the problem of minimizing average and peak AoI in a wireless networks, consisting of a set of source-destination links, under general interference constraints. When fresh information is always available for transmission, we show that a stationary scheduling policy is peak age optimal. We also prove that this policy achieves average age that is within a factor of two of the optimal average age. In the case where fresh information is not always available, and packet/information generation rate has to be controlled along with scheduling links for transmission, we prove an important separation principle: the optimal scheduling policy can be designed assuming fresh information, and independently, the packet generation rate control can be done by ignoring interference. Peak and average AoI for discrete time G/Ber/1 queue is analyzed for the first time, which may be of independent interest. Interference in Automotive Radar Systems: Characteristics, Mitigation Techniques, and Current and Future Research Article Sep 2019 Stephen Alland Wayne E. Stark Murtaza Ali Manju Hegde This article examines the problem of interference in automotive radar. Different types of automotive radar as well as mechanisms and characteristics of interference and the effects of interference on radar system performance are described. The interference-to-noise ratio (INR) at the output of a detector is a measure of the susceptibility of a radar to interference. The INR is derived from different types of interfering and victim radars and depends on the location of both as well as parameters such as transmit power, antenna gain, and bandwidth. In addition, for victim radar with beamscanning, INR depends on the location of the target the victim radar is attempting to detect. Analysis is presented to show the effects of various interference scenarios on the INR. A review of the current state of the art in interference mitigation techniques previously deployed as well as areas of research currently being addressed is then provided. Finally, important future research directions are suggested. Deep Reinforcement Learning for Mobile 5G and Beyond: Fundamentals, Applications, and Challenges Article Jun 2019 IEEE Veh Tech Mag Zehui Xiong Yang Zhang Dusit Niyato Li-Chun Wang Applications of Deep Reinforcement Learning in Communications and Networking: A Survey Article May 2019 Cong Luong Nguyen Hoang Dinh Thai Shimin Gong Dong In Kim This paper presents a comprehensive literature review on applications of deep reinforcement learning in communications and networking. Modern networks, e.g., Internet of Things (IoT) and Unmanned Aerial Vehicle (UAV) networks, become more decentralized and autonomous. In such networks, network entities need to make decisions locally to maximize the network performance under uncertainty of network environment. Reinforcement learning has been efficiently used to enable the network entities to obtain the optimal policy including, e.g., decisions or actions, given their states when the state and action spaces are small. However, in complex and large-scale networks, the state and action spaces are usually large, and the reinforcement learning may not be able to find the optimal policy in reasonable time. Therefore, deep reinforcement learning, a combination of reinforcement learning with deep learning, has been developed to overcome the shortcomings. In this survey, we first give a tutorial of deep reinforcement learning from fundamental concepts to advanced models. Then, we review deep reinforcement learning approaches proposed to address emerging issues in communications and networking. The issues include dynamic network access, data rate control, wireless caching, data offloading, network security, and connectivity preservation which are all important to next generation networks such as 5G and beyond. Furthermore, we present applications of deep reinforcement learning for traffic routing, resource sharing, and data collection. Finally, we highlight important challenges, open issues, and future research directions of applying deep reinforcement learning. Federated Learning for Ultra-Reliable Low-Latency V2V Communications Conference Paper Dec 2018 Sumudu Samarakoon Mehdi Bennis Walid Saad mérouane Debbah Deep Reinforcement Learning for Resource Allocation in V2V Communications Article Feb 2019 IEEE T VEH TECHNOL Ye Geoffrey Li Biing-Hwang Juang Hao Ye In this paper, we develop a novel decentralized resource allocation mechanism for vehicle-to-vehicle (V2V) communications based on deep reinforcement learning, which can be applied to both unicast and broadcast scenarios. According to the decentralized resource allocation mechanism, an autonomous “agent”, a V2V link or a vehicle, makes its decisions to find the optimal sub-band and power level for transmission without requiring or having to wait for global information. Since the proposed method is decentralized, it incurs only limited transmission overhead. From the simulation results, each agent can effectively learn to satisfy the stringent latency constraints on V2V links while minimizing the interference to vehicle-to-infrastructure communications. Design and Experimental Validation of a Cooperative Driving Control Architecture for the Grand Cooperative Driving Challenge 2016 Article Mar 2018 IEEE T INTELL TRANSP Robert Hult Feyyaz Emre Sancar Mehdi Jalalmaab Stefania Santini In this paper, we present the cooperative driving system developed by the Chalmers car team for the grand cooperative driving challenge 2016. This paper gives an overview of the system architecture and describes in detail the communication, signal processing, and decision-making sub-systems. Experimental results demonstrate the system's performance and operation according to the rules and requirements of the competition. Vehicle headway modeling and its inferences in macroscopic/microscopic traffic flow theory: A survey Article Mar 2017 TRANSPORT RES C-EMER Li Li Xiqun (Michael) Chen Autonomous driving at Ulm University: A modular, robust, and sensor-independent fusion approach Conference Paper Jun 2015 Felix Kunz Dominik Nuss Jurgen Wiest The project “Autonomous Driving” at Ulm University aims at advancing highly-automated driving with close-to-market sensors while ensuring easy exchangeability of the particular components. In this contribution, the experimental vehicle that was realized during the project is presented along with its software modules. To achieve the mentioned goals, a sophisticated fusion approach for robust environment perception is essential. Apart from the necessary motion planning algorithms, this paper thus focuses on the sensor-independent fusion scheme. It allows for an efficient sensor replacement and realizes redundancy by using probabilistic and generic interfaces. Redundancy is ensured by utilizing multiple sensors of different types in crucial modules like grid mapping, localization and tracking. Furthermore, the combination of the module outputs to a consistent environment model is achieved by employing their probabilistic representation. The performance of the vehicle is discussed using the experience from numerous autonomous driving tests on public roads. Optimizing age-of-information in a multi-class queueing system On the Feasibility of Distributed Sampling Rate Adaptation in Heterogeneous and Collaborative Wireless Sensor Networks Semi-Supervised Classification with Graph Convolutional Networks We present a scalable approach for semi-supervised learning on graph-structured data that is based on an efficient variant of convolutional neural networks which operate directly on graphs. We motivate the choice of our convolutional architecture via a localized first-order approximation of spectral graph convolutions. Our model scales linearly in the number of graph edges and learns hidden layer representations that encode both local graph structure and features of nodes. In a number of experiments on citation networks and on a knowledge graph dataset we demonstrate that our approach outperforms related methods by a significant margin. Directional Radio Propagation Path Loss Models for Millimeter-Wave Wireless Networks in the 28, 60, and 73 GHz Bands Fifth-generation (5G) cellular systems are likely to operate in the centimeter-wave (3-30 GHz) and millimeter-wave (30-300 GHz) frequency bands, where a vast amount of underutilized bandwidth exists world-wide. To assist in the research and development of these emerging wireless systems, a myriad of measurement studies have been conducted to characterize path loss in urban environments at these frequencies. The standard theoretical free space (FS) and Stanford University Interim (SUI) empirical path loss models were recently modified to fit path loss models obtained from measurements performed at 28 GHz and 38 GHz, using simple correction factors. In this paper, we provide similar correction factors for models at 60 GHz and 73 GHz. By imparting slope correction factors on the FS and SUI path loss models to closely match the close-in (CI) free space reference distance path loss models, millimeter-wave path loss can be accurately estimated (with popular models) for 5G cellular planning at 60 GHz and 73 GHz. Additionally, new millimeter-wave beam combining path loss models are provided at 28 GHz and 73 GHz by considering the simultaneous combination of signals from multiple antenna pointing directions between the transmitter and receiver that result in the strongest received power. Such directional channel models are important for future adaptive array systems at millimeter-wave frequencies. Learning Multiagent Communication with Backpropagation Many tasks in AI require the collaboration of multiple agents. Typically, the communication protocol between agents is manually specified and not altered during training. In this paper we explore a simple neural model, called CommNN, that uses continuous communication for fully cooperative tasks. The model consists of multiple agents and the communication between them is learned alongside their policy. We apply this model to a diverse set of tasks, demonstrating the ability of the agents to learn to communicate amongst themselves, yielding improved performance over non-communicative agents and baselines. In some cases, it is possible to interpret the language devised by the agents, revealing simple but effective strategies for solving the task at hand. Millimeter Wave Vehicular Communication to Support Massive Automotive Sensing As driving becomes more automated, vehicles are being equipped with more sensors generating even higher data rates. Radars (RAdio Detection and Ranging) are used for object detection, visual cameras as virtual mirrors, and LIDARs (Light Detection and Ranging) for generating high resolution depth associated range maps, all to enhance the safety and efficiency of driving. Connected vehicles can use wireless communication to exchange sensor data, allowing them to enlarge their sensing range and improve automated driving functions. Unfortunately, conventional technologies, such as dedicated short-range communication (DSRC) and 4G cellular communication, do not support the gigabit-per-second data rates that would be required for raw sensor data exchange between vehicles. This paper makes the case that millimeter wave (mmWave) communication is the only viable approach for high bandwidth connected vehicles. The motivations and challenges associated with using mmWave for vehicle-to-vehicle and vehicle-to-infrastructure applications are highlighted. A solution to one key challenge - the overhead of mmWave beam training - is proposed. The critical feature of this solution is to leverage information derived from the sensors or DSRC as side information for the mmWave communication link configuration. Examples and simulation results show that the beam alignment overhead can be reduced by using position information obtained from DSRC. Making Bertha Drive—An Autonomous Journey on a Historic Route 125 years after Bertha Benz completed the first overland journey in automotive history, the Mercedes Benz S-Class S 500 INTELLIGENT DRIVE followed the same route from Mannheim to Pforzheim, Germany, in fully autonomous manner. The autonomous vehicle was equipped with close-to-production sensor hardware and relied solely on vision and radar sensors in combination with accurate digital maps to obtain a comprehensive understanding of complex traffic situations. The historic Bertha Benz Memorial Route is particularly challenging for autonomous driving. The course taken by the autonomous vehicle had a length of 103 km and covered rural roads, 23 small villages and major cities (e.g. downtown Mannheim and Heidelberg). The route posed a large variety of difficult traffic scenarios including intersections with and without traffic lights, roundabouts, and narrow passages with oncoming traffic. This paper gives an overview of the autonomous vehicle and presents details on vision and radar-based perception, digital road maps and video-based self-localization, as well as motion planning in complex urban scenarios. 38 GHz and 60 GHz angle-dependent propagation for cellular & peer-to-peer wireless communications T.S. Rappaport As the cost of massively broadband® semiconductors continue to be driven down at millimeter wave (mm-wave) frequencies, there is great potential to use LMDS spectrum (in the 28-38 GHz bands) and the 60 GHz band for cellular/mobile and peer-to-peer wireless networks. This work presents urban cellular and peer-to-peer RF wideband channel measurements using a broadband sliding correlator channel sounder and steerable antennas at carrier frequencies of 38 GHz and 60 GHz, and presents measurements showing the propagation time delay spread and path loss as a function of separation distance and antenna pointing angles for many types of real-world environments. The data presented here show that at 38 GHz, unobstructed Line of Site (LOS) channels obey free space propagation path loss while non-LOS (NLOS) channels have large multipath delay spreads and can exploit many different pointing angles to provide propagation links. At 60 GHz, there is notably more path loss, smaller delay spreads, and fewer unique antenna angles for creating a link. For both 38 GHz and 60 GHz, we demonstrate empirical relationships between the RMS delay spread and antenna pointing angles, and observe that excess path loss (above free space) has an inverse relationship with transmitter-to-receiver separation distance. Intelligent Transportation Systems IEEE Veh Tech Mag The increasing need for mobility has brought about significant changes in transportation infrastructures. Inefficiencies cause enormous losses of time, decrease in the level of safety for both vehicles and pedestrians, high pollution, degradation of quality of life, and huge waste of nonrenewable fossil energy.The scope of this article is to introduce novel functionality for providing knowledge to vehicles, thus jointly managing traffic and safety. This will be achieved through the design of the proposed functionality, which, at a high level, will comprise (1) sensor networks formed by vehicles of a certain vicinity that exchange traffic-related information, (2) cognitive management functionality placed inside the vehicles for inferring knowledge and experience, and (3) cognitive management functionality in the overall transportation infrastructure. The goal of the aforementioned three main components shall be to issue directives to the drivers and the overall transportation infrastructure valuable in context handling. Digital communication systems
https://www.researchgate.net/publication/365115402_Intelligent_Resource_Allocation_in_Joint_Radar-Communication_With_Graph_Neural_Networks
Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa | Request PDF Request PDF | Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa | The increasing emergence of antibiotic resistance necessitates the development of anti-infectives with novel modes of action. Targeting bacterial... | Find, read and cite all the research you need on ResearchGate Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa ACS Infectious Diseases 4(6) DOI: 10.1021/acsinfecdis.8b00010 Request full-text Abstract The increasing emergence of antibiotic resistance necessitates the development of anti-infectives with novel modes of action. Targeting bacterial virulence is considered a promising approach to develop novel antibiotics with reduced selection pressure. The extracellular collagenase elastase (LasB) plays a pivotal role in the infection process of Pseudomonas aeruginosa and therefore represents an attractive anti-virulence target. Mercaptoacetamide-based thiols have been reported to inhibit LasB as well as collagenases from clostridia and bacillus species. The present work provides an insight into the Structure-Activity-Relationship (SAR) of these fragment-like LasB inhibitors, demonstrating an inverse activity profile compared to similar inhibitors of clostridial collagenase H (ColH). An X-ray co-crystal structure is presented, revealing distinct binding of two compounds to the active site of LasB, which unexpectedly maintains an open conformation. We further demonstrate in vivo efficacy in a Galleria mellonella infection model and high selectivity of the LasB inhibitors toward human matrix-metalloproteinases (MMPs). ... The inhibition of the P. aeruginosa quorum sensing was also reported with promising effects on biofilm development, virulence factor secretion and host colonization [26]. Among the P. aeruginosa virulence factors, Elastase B (LasB) is considered to be one of the most important [27,28]; its inhibition by small molecules improves the survival rate in mice and Galleria mellonella larvae [29] [30] [31][32]. ... ... As described in Figure 6, our group reported two new families of thiol inhibitors, which are articulated around N-aryl mercaptoacetamide (compounds 11-13) and N-aryl mercaptosuccinimide cores (compound 14). The N-aryl mercaptoacetamide family was discovered through a functional screening based on the FRET-based in vitro assay, which was previously reported by Nishino et al. [41], with a focused protease-inhibitor library [30] . This scaffold has also been reported by Janda et al. from in silico and in vitro studies [42]. ... ... In order to target both S1 and S2 subsites, we attempted to merge both molecules 11a and 11b through the use of N-aryl and N-aliphatic analogs. Unfortunately, this modulation did not allow us to improve the activity of 11 as these new derivatives display IC 50 values in the two-digit micromolar range [30] . However, interestingly, the introduction of the benzyl moiety in the α-position of the amide led to a slight increase in activity (compound 12, IC 50 = 2.7 µM), and strikingly, improved it 13-fold when the 3,4-dichloro group was replaced by a 4-methyl motif (compound 13, IC 50 = 0.5 µM) [31]. ... The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB Elastase B (LasB) is a zinc metalloprotease and a crucial virulence factor of Pseudomonas aeruginosa. As the need for new strategies to fight antimicrobial resistance (AMR) constantly rises, this protein has become a key target in the development of novel antivirulence agents. The extensive knowledge of the structure of its active site, containing two subpockets and a zinc atom, led to various structure-based medicinal chemistry programs and the optimization of several chemical classes of inhibitors. This review provides a brief reminder of the structure of the active site and a summary of the disclosed P. aeruginosa LasB inhibitors. We specifically focused on the analysis of their binding modes with a detailed representation of them, hence giving an overview of the strategies aiming at targeting LasB by small molecules. ... [100] Thiol-containing derivatives were also shown to be successful in terms of selectivity over several MMPs. [101] For hydroxamatebased inhibitors selectivity, however, remains an issue. [112,113] 3. Ta rgeting of Clostridial Collagenases ... ... [99,100] The discovery of the non-peptidic inhibitor compound 5 remains noteworthy as it demonstrated an in vivo effect in a Galleria mellonella infection model. [101] Substrateinspired merging and fragment-growing strategies applied on this structure yielded compound 6 demonstrating a 12-fold increase in potency while maintaining the selectivity and in vivo activity, demonstrating the potential for this new scaffold. [102] Nevertheless, nonpeptidic inhibitors continue to demonstrate low micromolar activities, whereas peptide-based compounds are active in the sub-micromolar range. ... ... [107][108][109] More than 20 different MMPs are present in humans, each classified based on their function and the depth of their S1' binding pocket. [107,110] On the other hand, dysfunction of these enzymes causes various diseases such as cancer, [68] N-aryl mercaptoacetamide 5, [101] α-benzyl N-aryl mercaptoacetamide 6, [102] phosphoramidon 7, [103,104] and a virtual screening hit compound 8. [105] ... Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents As resistance to clinically available antibiotics persistently increases, applying new strategies to target pathogenic bacteria are paramount to design effective drugs. Bacterial proteases play vital roles in cell viability and stress response, contributing to the pathogenicity of the resistant bacteria. Targeting these extracellular enzymes by antivirulence therapy is a prominent strategy in combating multi-drug resistant bacteria. By preventing the colonization and infiltration of the host, this method can lower selection pressure and reduce resistance development significantly. Here, we review the role of bacterial proteases, the rise of antivirulence therapy and we report on the development of novel antivirulence agents targeting two key virulence factors: elastase B (LasB) from Pseudomonas aeruginosa and collagenase H (ColH) from Clostridium histolyticum. ... 1: IC 50 (LasB) = 6.6 ± 0.3 µM). 25 For those compounds, lipophilic (multi-)substitution on the aryl ring was highly favored over hydrophilic para-substitution (compd. 1 four times more active than compd. 2: IC 50 (LasB) = 24 ± 1 µM). ... ... 30,31 This finding revealed that the modulation of the α-position might lead to inhibitors capable to occupy the lipophilic S1' binding pocket of LasB with their side chain and may therefore improve the inhibitory efficiency. 25, 26,30,31 To further explore the effects of other substituents in the α-position, we herein describe the design, synthesis, and biological evaluation of 35 novel α-alkylated mercaptoacetamides 6-40. ... ... For the α-unsubstituted mercaptoacetamides, we have demonstrated that nonpolar substituents on the aryl ring, in particular halogens, are more favorable for LasB inhibition than hydrophilic substituents. 25 However, in the case of α-benzylated derivatives, both polar and nonpolar groups were found to be beneficial for the activity. 30,31 Based on this, we decided to modify both the αside chain with a total of nine different alkyl substituents and the aryl moiety and to investigate the resultant LasB inhibitory activity. ... N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH Preprint Full-text available Antimicrobial resistance is currently one of the serious global public health threats. Unlike the conventional antimicrobial drugs, antivirulence agents disarm rather than kill bacterial pathogens and therefore represent an alternative option to skirt the problem of resistance. Pseudomonas aeruginosa elastase (LasB) and Clostridium histolyticum collagenase (ColH) are extracellular bacterial proteases which play a critical role in the establishment and progression of the respective bacterial infection. In this study, we report the modulation of the α-position of the previously reported N aryl mercaptoacetamide class leading to a new type of highly potent LasB and ColH inhibitors (N aryl 2-iso-butylmercaptoacetamides). In addition to their non-toxicity and high selectivity over several human off-targets, selected derivatives may be considered unprecedented dual inhibitors of both LasB and ColH. Among the prepared derivatives, compound 37 showed the most promising properties: it had a favorable safety profile, maintained the viability and integrity of both skin- and lung-cells treated with P. aeruginosa supernatant, demonstrated in vivo efficacy in Galleria mellonella larvae, and revealed a good volume of distribution and moderate in vivo clearance in mice. Taking together, these results demonstrate that compound 37 is a promising candidate for antivirulence drug development. ... An example of such approach include selection of metal chelators in a fragment screening campaign against gelatinase (Wang et al., 2002). Commercial fragment libraries dedicated for matrix metalloprotease (MMPs) such as Chelator Fragment Libraries (CFL 1.1), comprising a range of metal chelating moieties (Agrawal et al., 2008) and protease inhibitorenriched library (Baell and Holloway, 2010), have been deliberately chosen to target a matrix metalloproteinase, LasB (Garner et al., 2012; Kany et al., 2018a) . Another example of target-focussed libraries are halogen-enriched fragment libraries (HEFLibs), comprising chemical probes that identify halogen bonds as the main feature of binding mode, and originally constructed to find chemical moieties that stabilise p53 mutants (Heidrich et al., 2019). ... ... With the aim of expanding the chemical space of PaLasB inhibitors, a functional screening based on FRET-based in vitro assay (Nishino and Powers, 1980) was performed against PaLasB using 330 fragments (Maybridge Fragment Library) and a protease inhibitor-enriched library (Baell and Holloway, 2010) comprising of 1,192 low molecular weight compounds (Kany et al., 2018a) . This study led to the development of a thiobenzamide (N-(3,4dichlorophenyl)-2-sulfanylacetamide) 15, LasB inhibitor with thiol warhead, with an IC 50 of 6.6 μM ( Figure 4A). ... ... This was selective with regard to human MMPs. The X-ray structure of PaLasB-15 complex revealed that binding of 15 to LasB does not necessarily lead to closure of the binding site (Kany et al., 2018a) , unlike that described for thermolysin-like proteases (Adekoya et al., 2015), enzymes with high structural similarity to LasB. Moreover, two molecules of 15 were observed in the structure ( Figure 4B) and the binding of the second molecule was supposed to be supported by the binding of the first molecule. ... Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis Article Full-text available Mar 2022 Sheikh Mohammed Arif Andres Floto Tom L Blundell Cystic fibrosis (CF) is progressive genetic disease that predisposes lungs and other organs to multiple long-lasting microbial infections. Pseudomonas aeruginosa is the most prevalent and deadly pathogen among these microbes. Lung function of CF patients worsens following chronic infections with P. aeruginosa and is associated with increased mortality and morbidity. Emergence of multidrug-resistant, extensively drug-resistant and pandrug-resistant strains of P. aeruginosa due to intrinsic and adaptive antibiotic resistance mechanisms has failed the current anti-pseudomonal antibiotics. Hence new antibacterials are urgently needed to treat P. aeruginosa infections. Structure-guided fragment-based drug discovery (FBDD) is a powerful approach in the field of drug development that has succeeded in delivering six FDA approved drugs over the past 20 years targeting a variety of biological molecules. However, FBDD has not been widely used in the development of anti-pseudomonal molecules. In this review, we first give a brief overview of our structure-guided FBDD pipeline and then give a detailed account of FBDD campaigns to combat P. aeruginosa infections by developing small molecules having either bactericidal or anti-virulence properties. We conclude with a brief overview of the FBDD efforts in our lab at the University of Cambridge towards targeting P. aeruginosa infections. ... Interestingly, these compounds are potent inhibitors of P. aeruginosa LasB and collagenases from Clostridium and Bacillus species. 39, 40 Regarding LasB, in addition to the elucidation of the binding mode of our hit compound (1, Scheme 1), we demonstrated the in vivo efficacy of the same derivative in a Galleria mellonella larvae infection model. Moreover, compound 1 shows no cytotoxic effects on HepG2, HEK293 and A549 cells (see ESI, † Table S1) and its thiocarbamate prodrug 1a (see Scheme 1) remarkably displays high selectivity over several human matrix metalloproteases (MMPs). ... ... Moreover, compound 1 shows no cytotoxic effects on HepG2, HEK293 and A549 cells (see ESI, † Table S1) and its thiocarbamate prodrug 1a (see Scheme 1) remarkably displays high selectivity over several human matrix metalloproteases (MMPs). 39 It has been demonstrated that several thiol-containing drugs such as captopril (an angiotensin converting enzyme (ACE) inhibitor which is used for the treatment of hypertension), thiorphan (the active metabolite of racecadotril used for the treatment of diarrhoea), and tiopronin (which is used in patients with cystinuria, Fig. 2), display promising in vitro inhibitory activities toward different MBLs. 41 The shown three inhibitors all consist of the same core structure, that is, a 2-substituted (2-mercaptoacetyl)-or (2-mercatopropanoyl) glycine. ... ... Interestingly, our LasB inhibitor showed a strong inhibitory effect with a sub-micromolar IC 50 value (IC 50 = 0.86 ± 0.06 μM). 39 Based on the encouraging inhibitory activity of compound 1 against IMP-7, this study aimed to further investigate the inhibitory profile of the N-aryl mercaptoacetamide class against various MBLs. Aside from that, another goal was to explore the potential of using this class as multi-target inhibitors tackling both virulence and bacterial resistance. ... N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa Full-text available Samir Yahiaoui Katrin Voos Increasing antimicrobial resistance is evolving to be one of the major threats to public health. To reduce the selection pressure and thus to avoid a fast development of resistance, novel approaches aim to target bacterial virulence instead of growth. Another strategy is to restore the activity of antibiotics already in clinical use. This can be achieved by the inhibition of resistance factors such as metallo-β-lactamases (MBLs). Since MBLs can cleave almost all β-lactam antibiotics, including the "last resort" carbapenems, their inhibition is of utmost importance. Here, we report on the synthesis and in vitro evaluation of N-aryl mercaptoacetamides as inhibitors of both clinically relevant MBLs and the virulence factor LasB from Pseudomonas aeruginosa. All tested N-aryl mercaptoacetamides showed low micromolar to submicromolar activities on the tested enzymes IMP-7, NDM-1 and VIM-1. The two most promising compounds were further examined in NDM-1 expressing Klebsiella pneumoniae isolates, where they restored the full activity of imipenem. Together with their LasB-inhibitory activity in the micromolar range, this class of compounds can now serve as a starting point for a multi-target inhibitor approach against both bacterial resistance and virulence, which is unprecedented in antibacterial drug discovery. ... In our previous work, we discovered N-aryl mercaptoacetamide inhibitors with low micromolar and nanomolar affinities toward LasB and ColH, respectively. 29, 30 To constrain the flexibility and freeze the active conformation of our previously published thiols, we designed a novel succinimide class ( Figure 2). The succinimide core has been reported for inhibitors of various enzyme targets, such as serine proteases, 31 human leukocyte elastase, cathepsin G and proteinase 3, 32 tumor necrosis factor, and phosphodiesterase. ... ... We designed the initial succinimide core based on our previously published N-aryl mercaptoacetamide inhibitors. 29, 30 To expand the structure− activity relationships (SARs) further and provide more detailed information on the aromatic moiety's influence on the activity, we designed a series of compounds bearing polar, lipophilic, electron-withdrawing or -donating functional groups. In order to prevent disulfide formation, we protected the free thiol group in the form of thioacetate. ... ... In our previous work, we have shown that there is a structural similarity between the inhibitors of LasB and ColH. 29, 30 It was therefore of interest to investigate the activity of all new compounds against ColH and to compare the SAR with that observed for LasB. Figure 3 represents the inhibition of the peptidase domain of ColH (ColH-PD) in the presence of 1 μM of the selected compounds. Previously, we reported that polar substituents in para-position have the most beneficial effect on the activity of N-aryl mercaptoacetamides. ... N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases Article Full-text available Anna K. H. Hirsch Samir Yahiaoui In light of the global antimicrobial-resistance crisis, there is an urgent need for novel bacterial targets and antibiotics with novel modes of action. It has been shown that Pseudomonas aeruginosa elastase (LasB) and Clostridium histolyticum (Hathewaya histolytica) collagenase (ColH) play a significant role in the infection process and thereby represent promising antivirulence targets. Here, we report novel N-aryl-3-mercaptosuccinimide inhibitors that target both LasB and ColH, displaying potent activities in vitro and high selectivity for the bacterial over human metalloproteases. Additionally, the inhibitors demonstrate no signs of cytotoxicity against selected human cell lines and in a zebrafish embryo toxicity model. Furthermore, the most active ColH inhibitor shows a significant reduction of collagen degradation in an ex vivo pig skin model. View Show abstract ... 28−32 A class of N-aryl mercaptoacetamides turned out to be particularly attractive because these thiols display high selectivity against a range of human matrix metalloproteinases (MMPs). 32, 33 Thiol-containing compounds are in clinical use for the treatment of various diseases. 34−36 However, a disadvantage of this class compared to other zincchelating inhibitors is the possible oxidation to the respective disulfides, resulting in inactivation of the compounds. ... ... By introduction of these relatively small zinc chelating groups, drastic changes in the size of the thiol function of 1 were avoided to allow the inhibitor backbone to preserve the previously observed binding mode. 32 Carboxylic acid derivatives 3, 4, and 6 were obtained either by reacting aniline 2 with succinic/maleic anhydride or via hydrolysis of methylester intermediate 5. Similarly, 7 was synthesized by reacting 5 with hydroxylamine (Schemes 1A and B). As an isosteric modification we further synthesized the alcohol derivative of 1, compound 8, using glycolic acid in a neat reaction (Scheme 1C). ... ... 45 Intriguingly, thiol 1 has recently been discovered by us to keep the active site cleft in an open conformation due to the unexpected binding of two molecules to the primed binding site (Supplementary Figure S1). 32 In contrast, only one molecule of the hydroxamate binds to the protease, which undergoes the characteristic hinge-bending. Unlike the zinc-chelating thiol, the hydroxamate directly interacts with the edge strand via a hydrogen bond with the main chain oxygen of Ala113. ... Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor Asfandyar Sikandar In search of novel antibiotics to combat the challenging spread of resistant pathogens, bacterial proteases represent promising targets for pathoblocker development. A common motif for protease inhibitors is the hydroxamic acid function, yet this group has often been related to unspecific inhibition of various metalloproteases. In this work, the inhibition of LasB, a harmful zinc metalloprotease secreted by Pseudomonas aeruginosa, through a hydroxamate derivative is described. The present inhibitor was developed based on a recently reported, highly selective thiol scaffold. Using X-ray crystallography, the lack of inhibition of a range of human matrix-metalloproteases could be attributed to a distinct binding mode sparing the S1´ pocket. The inhibitor was shown to restore the effect of the antimicrobial peptide LL 37, to reduce the formation of P. aeruginosa biofilm and, for the first time for a LasB inhibitor, the release of extracellular DNA. Hence, it is capable of disrupting several important bacterial resistance mechanisms. These results highlight the potential of protease inhibitors to fight bacterial infections and point out the possibility to achieve selective inhibition even with a strong zinc anchor. ... The inhibitory activity of the final compounds against LasB was determined as previously reported (Table 1). 43 The electron-withdrawing nitro substituent in the paraposition in compound 11 proved to be less beneficial for the activity compared to the methyl group in compound 3. A slight improvement in potency was achieved through the methoxy group in compound 12. ... ... IC 50 values for all nine derivatives against LasB were determined as reported previously (Table 2). 43 Replacement of the N-aryl ring with a thiazolyl group in compound 18 maintained the potency in the range of compound 5. Interestingly, with a relatively small substituent, methyl thiophenyl 3-carboxylate in compound 19, we observed an almost fivefold drop in IC 50 value, presumably caused by unfavorable interactions due to the highly hydrophobic nature of the binding pocket. ... Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa Isabell Walter Alaa Alhayek Antivirulence therapy has become a widely applicable method for fighting infections caused by multidrug-resistant bacteria. Among the many virulence factors produced by the Gram-negative bacterium Pseudomonas aeruginosa, elastase (LasB) stands out as an important target as it plays a pivotal role in the invasion of the host tissue and evasion of the immune response. In this work, we explored the recently reported LasB inhibitor class of α-benzyl-N-aryl mercaptoacetamides by exploiting the crystal structure of one of the compounds. Our exploration yielded inhibitors that maintained inhibitory activity, selectivity, and increased hydrophilicity. These inhibitors were found to reduce the pathogenicity of the bacteria and to maintain the integrity of lung and skin cells in the diseased state. Furthermore, two most promising compounds increased the survival rate of Galleria mellonella larvae treated with P. aeruginosa culture supernatant. ... To support these tasks, theoretical studies oriented to characterize inhibitor interactions with the LasB crystal enzyme [16] could help with the development of new specific drugs to avoid antibiotic resistance in P. aeruginosa. Despite the widespread use of computational methods for drug design, there are a few studies related to the LasB inhibitors [17][18] [19] . Fortunately, LasB-ligand complexes have been reported by X-ray crystallography [19]. Notwithstanding of several biological evaluations of sets of LasB inhibitors [13][14][15]17,18,20,21], a quantitative structure-activity relationship (QSAR) to predict and correlate the efficiency of the molecules reported is not present in the literature; neither is a deep description of the LasB binding site. ... ... Despite the widespread use of computational methods for drug design, there are a few studies related to the LasB inhibitors [17][18][19]. Fortunately, LasB-ligand complexes have been reported by X-ray crystallography [19] . Notwithstanding of several biological evaluations of sets of LasB inhibitors [13][14][15]17,18,20,21], a quantitative structure-activity relationship (QSAR) to predict and correlate the efficiency of the molecules reported is not present in the literature; neither is a deep description of the LasB binding site. ... Structural Requirements of N-alpha-Mercaptoacetyl Dipeptide (NAMdP) Inhibitors of Pseudomonas Aeruginosa Virulence Factor LasB: 3D-QSAR, Molecular Docking, and Interaction Fingerprint Studies Full-text available Dec 2019 INT J MOL SCI José Luis Velázquez Libera Juliana Andrea Murillo López Alexander F. de la Torre Julio Caballero The zinc metallopeptidase Pseudomonas elastase (LasB) is a virulence factor of Pseudomonas aeruginosa (P. aeruginosa), a pathogenic bacterium that can cause nosocomial infections. The present study relates the structural analysis of 118 N-alpha-mercaptoacetyl dipeptides (NAMdPs) as LasB inhibitors. Field-based 3D-QSAR and molecular docking methods were employed to describe the essential interactions between NAMdPs and LasB binding sites, and the chemical features that determine their differential activities. We report a predictive 3D-QSAR model that was developed according to the internal and external validation tests. The best model, including steric, electrostatic, hydrogen bond donor, hydrogen bond acceptor, and hydrophobic fields, was found to depict a three-dimensional map with the local positive and negative effects of these chemotypes on the LasB inhibitory activities. Furthermore, molecular docking experiments yielded bioactive conformations of NAMdPs inside the LasB binding site. The series of NAMdPs adopted a similar orientation with respect to phosphoramidon within the LasB binding site (crystallographic reference), where the backbone atoms of NAMdPs are hydrogen-bonded to the LasB residues N112, A113, and R198, similarly to phosphoramidon. Our study also included a deep description of the residues involved in the protein-ligand interaction patterns for the whole set of NAMdPs, through the use of interaction fingerprints (IFPs). ... µM for 64 and an IC50 = 1.16 ± 0.07 µM for 63, ensuring the future development of novel anti-infective compounds. Finally, the in vitro efficacy towards Galleria mellonella infection models was investigated, and the results suggested that the prodrug 63 did not sufficiently release the active thiol 64 [90] . ... Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives Article Full-text available May 2023 MOLECULES Riccardo Di Di Leo Doretta Cuffaro Armando Rossello Elisa Nuti Human deaths caused by Gram-negative bacteria keep rising due to the multidrug resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with different mechanisms of action. Several bacterial zinc metalloenzymes are becoming attractive targets since they do not show any similarities with the human endogenous zinc-metalloproteinases. In the last decades, there has been an increasing interest from both industry and academia in developing new inhibitors against those enzymes involved in lipid A biosynthesis, and bacteria nutrition and sporulation, e.g., UDP-[3-O-(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC), thermolysin (TLN), and pseudolysin (PLN). Nevertheless, targeting these bacterial enzymes is harder than expected and the lack of good clinical candidates suggests that more effort is needed. This review gives an overview of bacterial zinc metalloenzyme inhibitors that have been synthesized so far, highlighting the structural features essential for inhibitory activity and the structure–activity relationships. Our discussion may stimulate and help further studies on bacterial zinc metalloenzyme inhibitors as possible novel antibacterial drugs. View Show abstract ... The toxicity of selected compounds towards three cell lines was determined as described previously. 28 Table S1. ... Design and synthesis of inhibitors of ColH and LasB Thesis Jan 2022 Cansu Kaya ... The peptide sequence H 2 N-Ala-Gly-Leu-Ala-COOH is an established substrate for the bacterial endopeptidase LasB, which specifically cuts between Gly and Leu. 57, 61 This peptide motif can thus be exploited as a cleavable linker between the carbohydrate lectin probe and the antibiotic drug, which are conjugated to the N-and C-termini, respectively. This capping of the peptide protects it from unspecific cleavage by other host-derived exopeptidases, resulting in sufficient metabolic stability. ... Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release Article Full-text available Oct 2022 Joscha Meiers Katharina Rox Alexander Titz Chronic Pseudomonas aeruginosa infections are characterized by biofilm formation, a major virulence factor of P. aeruginosa and cause of extensive drug resistance. Fluoroquinolones are effective antibiotics but are linked to severe side effects. The two extracellular P. aeruginosa-specific lectins LecA and LecB are key structural biofilm components and can be exploited for targeted drug delivery. In this work, several fluoroquinolones were conjugated to lectin probes by cleavable peptide linkers to yield lectin-targeted prodrugs. Mechanistically, these conjugates therefore remain non-toxic in the systemic distribution and will be activated to kill only once they have accumulated at the infection site. The synthesized prodrugs proved stable in the presence of host blood plasma and liver metabolism but rapidly released the antibiotic cargo in the presence of P. aeruginosa in a self-destructive manner in vitro. Furthermore, the prodrugs showed good absorption, distribution, metabolism, and elimination (ADME) properties and reduced toxicity in vitro, thus establishing the first lectin-targeted antibiotic prodrugs against P. aeruginosa. ... As a major virulence factor of P. aeruginosa, it cleaves host tissue components such as elastin or collagen, disrupts cell-to-cell junctions, and causes tissue damages. The mercaptoacetamidebased compounds, phendione and its iron complexes, were proven to be effective LasB inhibitors that prolonged survival of P. aeruginosa-infected G. mellonella larvae (Kany et al., 2018; Galdino et al., 2019;Kaya et al., 2022). Alginate, produced by P. aeruginosa strains isolated from cystic fibrosis (CF) patients with chronic pulmonary infections, plays an important role in the pathology of CF disease by contributing to bacterial adhesion and biofilm formation (May et al., 1991;Boyd and Chakrabarty, 1995;Franklin et al., 2011). ... Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance Article Full-text available Jul 2022 Chongbing Liao Xin Huang Qingxia Wang Wuyuan Lu Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in severely ill and immunocompromised patients. Ubiquitously disseminated in the environment, especially in hospitals, it has become a major threat to human health due to the constant emergence of drug-resistant strains. Multiple resistance mechanisms are exploited by P. aeruginosa, which usually result in chronic infections difficult to eradicate. Diverse virulence factors responsible for bacterial adhesion and colonization, host immune suppression, and immune escape, play important roles in the pathogenic process of P. aeruginosa. As such, antivirulence treatment that aims at reducing virulence while sparing the bacterium for its eventual elimination by the immune system, or combination therapies, has significant advantages over traditional antibiotic therapy, as the former imposes minimal selective pressure on P. aeruginosa, thus less likely to induce drug resistance. In this review, we will discuss the virulence factors of P. aeruginosa, their pathogenic roles, and recent advances in antivirulence drug discovery for the treatment of P. aeruginosa infections. ... The initial portion of this lecture described their successful identification and characterization of a mercaptoacetamide containing a hit fragment. 58 Inspired by the natural substrate, a subsequent fragment merging, elaboration, and growing strategy resulted in a small molecule candidate with substantially improved activity, compared to the fragment hit, coupled to in vivo activity in a Galleria mellonella larvae model of infection. 59 David Hilko (Griffith University), delivered a lecture describing the incorporation of an improved synthesis of ethynyl-2′-deoxyuridines (EdU) and its application as a chemical probe for the fluorescent labeling of DNA. ... ICBS 2021: Looking Toward the Next Decade of Chemical Biology Article Mar 2022 ACS CHEM BIOL Clinton G. L. Veale Arindam Talukdar Boris Vauzeilles Hosted virtually by Emory University, through its cochairs Haian Fu (Emory University), Sally-Ann Poulsen (Griffith University), Huw Davies (Emory University), and Alanna Schepartz (UC Berkeley), the International Chemical Biology Society (ICBS) held its 10th Annual Conference from November 10th to 13th 2021. Building on the progress from previous meetings, (1−7) the theme of this year’s event “Looking Towards the Next Decade of Chemical Biology” blended a diverse array of established and early career speakers working under the cross-disciplinary umbrella of chemical biology. In what was a tightly packed schedule, ICBS 2021 consisted of 14 focused sessions and two trainee presentation sessions, in which a total of 69 “podium” presentations were given. In addition, attendees enjoyed six invited keynote lectures and the ICBS Global Lectureship Award. The scientific lecture schedule was complimented by forums discussing the early career chemical biology space, and the next decade of chemical biology, respectively, in addition to two networking and professional development sessions, live poster sessions, and the ICBS business meeting. ... Moreover, bacterial collagenases have been explored as promising targets for inhibiting bacterial invasion without affecting viability of the bacteria [10] [11] [12][13]. Whereas the above calls for collagenase inhibition, many applications may benefit from optimized collagenase variants that harbor higher activity and stability. ... Screening Collagenase Activity in Bacterial Lysate for Directed Enzyme Applications Collagenases are essential enzymes capable of digesting triple-helical collagen under physiological conditions. These enzymes play a key role in diverse physiological and pathophysiological processes. Collagenases are used for diverse biotechnological applications, and it is thus of major interest to identify new enzyme variants with improved characteristics such as expression yield, stability, or activity. The engineering of new enzyme variants often relies on either rational protein design or directed enzyme evolution. The latter includes screening of a large randomized or semirational genetic library, both of which require an assay that enables the identification of improved variants. Moreover, the assay should be tailored for microplates to allow the screening of hundreds or thousands of clones. Herein, we repurposed the previously reported fluorogenic assay using 3,4-dihydroxyphenylacetic acid for the quantitation of collagen, and applied it in the detection of bacterial collagenase activity in bacterial lysates. This enabled the screening of hundreds of E. coli colonies expressing an error-prone library of collagenase G from C. histolyticum, in 96-well deep-well plates, by measuring activity directly in lysates with collagen. As a proof-of-concept, a single variant exhibiting higher activity than the starting-point enzyme was expressed, purified, and characterized biochemically and computationally. This showed the feasibility of this method to support medium-high throughput screening based on direct evaluation of collagenase activity. ... Using a combination of in silico docking and in vitro testing, Zhu et al. identified a mercaptoacetamidebased thiol scaffold to develop a compound that effectively limited LasB-dependent virulence in C. elegans without impacting other matrix metalloproteases (19). Another group, using a solely in vitro screening approach, assayed ;1.5K small molecules and identified a single mercaptoacetamide-based thiol that inhibited LasB activity and rescued Galleria mellonella from P. aeruginosa pathogenesis (95) . A careful analysis demonstrated that the compound interacted with the zinc-based active site of the metalloprotease, which is likely to be the mechanism for all mercaptoacetamide-based LasB inhibitors. ... High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents Article Full-text available Antimicrobial resistance is a serious medical threat, particularly given the decreasing rate of discovery of new treatments. Although attempts to find new treatments continue, it has become clear that merely discovering new antimicrobials, even if they are new classes, will be insufficient. It is essential that new strategies be aggressively pursued. Toward that end, the search for treatments that can mitigate bacterial virulence and tilt the balance of host-pathogen interactions in favor of the host has become increasingly popular. In this review, we will discuss recent progress in this field, with a special focus on synthetic small molecule antivirulents that have been identified from high-throughput screens and on treatments that are effective against the opportunistic human pathogen Pseudomonas aeruginosa . ... This bacterial species has many virulence factors as a strategy for survival in the host (Feng et al., 2016). The nosocomial and toxicogenic P. aeruginosa is a highly adaptable opportunistic bacteria that prevalent in patients with immuno-compromised cystic fibrosis causing invasive infections (Kany et al., 2018) ; it is responsible of 10% of total infections in the hospitals (Fazeli et al., 2012). In burned patients P. aeruginosa is the causative agents of invasive infections, it is known as a resistant bacteria to a wide range of antimicrobial agents and the host immune system due to their ability in forming biofilms, causing difficulties in medical treatments (Alhazmi,2015). ... Antibacterial and Anti virulence factors of Purified Dextran from Lactobacillus gasseri against Pseudomonas aeruginosa The objective of the current study is to purify and characterize dextran from Lactobacillus gasseri and to detect its anti-virulence factors against hemolysin, pyocyanin, and biofilm formation of clinical Pseudomonas aeruginosa isolated from wounds and burns. Purification and characterization of dextran were carried out by a Thin Layer Chromatography (TLC) and a Fourier Trans Infrared Spectroscopy (FTIR). Purified dextran obtained was white, granular, and easily soluble in water. TLC results showed that the purified dextran was composed of glucose only; while FTIR showed that dextran polysaccharide contained both (1-6) ∝-D glucan and (1-3) ∝-glucan. Antibacterial effect of purified dextran was determined against P.aeruginosa isolates using Minimum Inhibitory Concentration (MIC) with concentrations ranging between 0.39 to 200 mg/ml; the MIC was 50 mg/ ml for all isolates. On the other hand, the effect of dextran on the virulence factors of P.aeruginosa was evaluated. Dextran inhibited hemolysin production of P.aeruginosa and the highest inhibition recorded was 29.03%. Pyocyanin production by P.aeruginosa clinical isolates was inhibited by dextran and the concentration was recorded between 2.28-2.35 μg/ml compared with 3.31-3.39 μg/ml for control. The effect of purified dextran on biofilm formation was studied at different incubation periods (24, 48 and 72 h), the highest biofilm inhibition was observed after 72 h was 71.42 %, while the lowest inhibition after 24 h was 37.66% compared to control, which recorded 0% in the absence of dextran. In conclusion, the purified and characterized dextran from local L. gasseri had an inhibitory effect on the growth and virulence factors of clinical P. aeruginosa isolated from wounds and burns. ... Our lab has identified several compounds that inhibit pyoverdine function and rescue C. elegans hosts during P. aeruginosa pathogenesis [43]. Inhibitors of the type III secretion system, elastase LasB, and quorum-sensing have also been identified and validated using these model pathosystems [52][53][54] [55] . ... An In Vitro Cell Culture Model for Pyoverdine-Mediated Virulence Pseudomonas aeruginosa is a multidrug-resistant, opportunistic pathogen that utilizes a wide-range of virulence factors to cause acute, life-threatening infections in immunocompromised patients, especially those in intensive care units. It also causes debilitating chronic infections that shorten lives and worsen the quality of life for cystic fibrosis patients. One of the key virulence factors in P. aeruginosa is the siderophore pyoverdine, which provides the pathogen with iron during infection, regulates the production of secreted toxins, and disrupts host iron and mitochondrial homeostasis. These roles have been characterized in model organisms such as Caenorhabditis elegans and mice. However, an intermediary system, using cell culture to investigate the activity of this siderophore has been absent. In this report, we describe such a system, using murine macrophages treated with pyoverdine. We demonstrate that pyoverdine-rich filtrates from P. aeruginosa exhibit substantial cytotoxicity, and that the inhibition of pyoverdine production (genetic or chemical) is sufficient to mitigate virulence. Furthermore, consistent with previous observations made in C. elegans, pyoverdine translocates into cells and disrupts host mitochondrial homeostasis. Most importantly, we observe a strong correlation between pyoverdine production and virulence in P. aeruginosa clinical isolates, confirming pyoverdine’s value as a promising target for therapeutic intervention. This in vitro cell culture model will allow rapid validation of pyoverdine antivirulents in a simple but physiologically relevant manner. ... P. aeruginosa rhlR gene, as a regulator member of the rhl system (second QS system), controls coding a set of virulence genes, including those involved in the secretion of pyocyanin and rhamnolipid [14]. The lasB regulates the transcription of metalloprotease elastase [15], resulting in suppression of the immune system and degradation of elastin and collagen [16] . Finally, P. aeruginosa toxA increases the secretion of exotoxin A, the most toxic extra cellular secretion and one of the major virulence factors of P. aeruginosa [17,18]. ... Real-time polymerase chain reaction assays for rapid detection and virulence evaluation of the environmental Pseudomonas aeruginosa isolates Rapid and species-specific detection, and virulence evaluation of opportunistic pathogens such as Pseudomonas aeruginosa, are issues that increasingly has attracted the attention of public health authorities. A set of primers and hydrolysis probe was designed based on one of the P. aeruginosa housekeeping genes, gyrB, and its specificity and sensitivity was evaluated by TaqMan qPCR methods. The end point PCR and SYBR Green qPCR were used as control methods. Furthermore, multiplex RT-qPCRs were developed for gyrB as reference and four virulence genes, including lasB, lasR, rhlR and toxA. Totally, 40 environmental samples, two clinical isolates from CF patients, two standard strains of P. aeruginosa, and 15 non-target reference strains were used to test the sensitivity and specificity of qPCR assays. In silico and in vitro cross-species testing confirmed the high specificity and low cross-species amplification of the designed gyrB418F/gyrB490R/gyrB444P. The sensitivity of both TaqMan and SYBR Green qPCRs was 100% for all target P. aeruginosa, and the detected count of bacteria was below ten genomic equivalents. The lowest M value obtained from gene-stability measurement was 0.19 that confirmed the suitability of gyrB as the reference gene for RT-qPCR. The developed qPCRs have enough detection power for identification of P. aeruginosa in environmental samples including clean and recreational water, treated and untreated sewage and soil. The short amplicon length of our designed primers and probes, alongside with a low M value, make it as a proper methodology for RT-qPCR in virulence genes expression assessment. View ... The X-ray crystallography analyzes revealed that this compound did not block the access of the substrate to the catalytic pocket. However, the mercaptoacetamide derivative compound avoided the closure of the active site, preventing the proteolytic action [118] . ... Anti-Virulence Strategy against the Multidrug-Resistant Bacterial Pathogen Pseudomonas aeruginosa: Pseudolysin (Elastase B) as a Potential Druggable Target Pseudomonas aeruginosa is a non-fermentative, gram-negative bacterium that is one of the most common pathogens responsible for hospital-acquired infections worldwide. The management of the infections caused by P. aeruginosa represents a huge challenge in healthcare settings due to the increased emergence of resistant isolates, some of them resistant to all the currently available antimicrobials, which results in elevated morbimortality rates. Consequently, the development of new therapeutic strategies against multidrug-resistant P. aeruginosa is urgent and needful. P. aeruginosa is well-recognized for its extreme genetic versatility and its ability to produce a lush variety of virulence factors. In this context, pseudolysin (or elastase B) outstands as a pivotal virulence attribute during the infectious process, playing multifunctional roles in different aspects of the pathogen-host interaction. This protein is a 33-kDa neutral zinc-dependent metallopeptidase that is the most abundant peptidase found in pseudomonal secretions, which contributes to the invasiveness of P. aeruginosa due to its ability to cleave several extracellular matrix proteins and to disrupt the basolateral intercellular junctions present in the host tissues. Moreover, pseudolysin makes P. aeruginosa able to overcome host defenses by the hydrolysis of many immunologically relevant molecules, including antibodies and complement components. The attenuation of this striking peptidase therefore emerges as an alternative and promising anti-virulence strategy to combat antibiotic-refractory infections caused by P. aeruginosa. The anti-virulence approach aims to disarm the P. aeruginosa infective arsenal by inhibiting the expression/activity of bacterial virulence factors in order to reduce the invasiveness of P. aeruginosa, avoiding the emergence of resistance since the proliferation is not affected. This review summarizes the most relevant features of pseudolysin and highlights this enzyme as a promising target for the development of new anti-virulence compounds. ... Pseudomonas aeruginosa 188 Kany ... Development of Pathoblockers by Targeting Secreted Bacterial Proteases Andreas M. Kany View ... IMPI is more specific and more potent than other PE-inhibitors [28] such as those based on hydroxamate, [37] metal-chelating dipeptides, [38][39][40] or small molecules. [40] Kany et al. [41] analyzed the structure-activity relationship of several PE-inhibitors in detail. ... The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa Objectives The objective of this study was to investigate the therapeutic potential of the insect metalloproteinase inhibitor (IMPI) from Galleria mellonella, the only known specific inhibitor of M4 metalloproteinases. Methods The fusion protein IMPI‐GST (glutathione‐S‐transferase) was produced by fermentation in Escherichia coli and was tested for its ability to inhibit the proteolytic activity of the M4 metalloproteinases thermolysin and Pseudomonas elastase (PE), the latter a key virulence factor of the wound‐associated and antibiotic‐resistant pathogen Pseudomonas aeruginosa. We also tested the ability of IMPI to inhibit the secretome (Sec) of a P. aeruginosa strain obtained from a wound. Key findings We found that IMPI‐GST inhibited thermolysin and PE in vitro and increased the viability of human keratinocytes exposed to Sec by inhibiting detachment caused by changes in cytoskeletal morphology. IMPI‐GST also improved the cell migration rate in an in vitro wound assay and reduced the severity of necrosis caused by Sec in an ex vivo porcine wound model. Conclusions The inhibition of virulence factors is a novel therapeutic approach against antibiotic resistant bacteria. Our results indicate that IMPI is a promising drug candidate for the treatment of P. aeruginosa infections. Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors In order to develop novel inhibitors of the bacterial deacetylase LpxC bearing a substituent to target the UDP binding site of the enzyme, a series of aldotetronic acid-based hydroxamic acids was accessed in chiral pool syntheses starting from 4,6-O-benzylidene-d-glucose and l-arabinitol. The synthesized hydroxamic acids were tested for LpxC inhibitory activity in vitro, revealing benzyl ether 17a ((2S,3S)-4-(benzyloxy)-N,3-dihydroxy-2-[(4-{[4-(morpholinomethyl)phenyl]ethynyl}benzyl)oxy]butanamide) as the most potent LpxC inhibitor. This compound was additionally tested for antibacterial activity against a panel of clinically relevant Gram-negative bacteria, bacterial uptake, and susceptibility to efflux pumps. Molecular docking studies were performed to rationalize the observed structure-activity relationships. N -Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases Drug-resistant pathogens pose a global challenge to public health as they cause diseases that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are a diverse set of zinc-containing enzymes that catalyze the hydrolysis of β-lactam drugs, including carbapenems, which are considered as the last resort to fight severe infections. To restore the activity of current β-lactam antibiotics and to offer an orthogonal strategy to the discovery of new antibiotics, we have identified a series of polar N-aryl mercaptopropionamide derivatives as potent inhibitors of several class B1 MBLs. We have identified a hit structure with high selectivity restoring the effect of imipenem and reducing minimum inhibitory concentration (MIC) values up to 256-fold in resistant isolates from Escherichia coli. Furthermore, the combination of imipenem with our inhibitor showed in vivo efficacy in a Galleria mellonella model, increasing the survival rate of infected larvae by up to 31%. Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections Despite the progress in surgical techniques and antibiotic prophylaxis, opportunistic wound infections with Bacillus cereus remain a public health problem. Secreted toxins are one of the main factors contributing to B. cereus pathogenicity. A promising strategy to treat such infections is to target these toxins and not the bacteria. Although the exoenzymes produced by B. cereus are thoroughly investigated, little is known about the role of B. cereus collagenases in wound infections. In this report, the collagenolytic activity of secreted collagenases (Col) is characterized in the B. cereus culture supernatant (csn) and its isolated recombinantly produced ColQ1 is characterized. The data reveals that ColQ1 causes damage on dermal collagen (COL). This results in gaps in the tissue, which might facilitate the spread of bacteria. The importance of B. cereus collagenases is also demonstrated in disease promotion using two inhibitors. Compound 2 shows high efficacy in peptidolytic, gelatinolytic, and COL degradation assays. It also preserves the fibrillar COLs in skin tissue challenged with ColQ1, as well as the viability of skin cells treated with B. cereus csn. A Galleria mellonella model highlights the significance of collagenase inhibition in vivo. Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors Extracellular virulence factors have emerged as attractive targets in the current antimicrobial resistance crisis. The Gram-negative pathogen Pseudomonas aeruginosa secretes the virulence factor elastase B (LasB), which plays an important role in the infection process. Here, we report a sub-micromolar, non-peptidic, fragment-like inhibitor of LasB discovered by careful visual inspection of structural data. Inspired by the natural LasB substrate, the original fragment was successfully merged and grown. The optimized inhibitor is accessible via simple chemistry and retained selectivity with a substantial improvement in activity, which can be rationalized by the crystal structure of LasB in complex with the inhibitor. We also demonstrate an improved in viv o efficacy of the optimized hit in Galleria mellonella larvae, highlighting the significance of this class of compounds as promising drug candidates. Substrate‐inspired fragment merging and growing affords efficacious LasB inhibitors Extracellular virulence factors have emerged as attractive targets in the current antimicrobial resistance crisis. The Gram‐negative pathogen Pseudomonas aeruginosa secretes the virulence factor elastase B (LasB), which plays an important role in the infection process. Here, we report a sub‐micromolar, non‐peptidic, fragment‐like inhibitor of LasB discovered by careful visual inspection of structural data. Inspired by the natural LasB substrate, the original fragment was successfully merged and grown. The optimized inhibitor is accessible via simple chemistry and retained selectivity with a substantial improvement in activity, which can be rationalized by the crystal structure of LasB in complex with the inhibitor. We also demonstrate an improved in viv o efficacy of the optimized hit in Galleria mellonella larvae, highlighting the significance of this class of compounds as promising drug candidates. Pseudomonas aeruginosa elastase (LasB) as a therapeutic target The Pseudomonas aeruginosa LasB elastase (elastase B, pseudolysin) is the predominant protease in the P. aeruginosa secretome. It has been shown to hydrolyse a vast array of host and pathogen proteins, degrading some, activating others, and causing damage to tissues, disrupting host immune responses, and promoting inflammation. It is a virulence factor in P. aeruginosa lung infections and has been proposed as an attractive target for the development of a novel antivirulence therapy. In this review, we summarise the activities and biological roles of LasB and focus on efforts to identify and develop specific LasB inhibitor drugs as adjuncts in the treatment of P. aeruginosa infections. Phosphonate as Stable Zinc‐binding Group for Inhibitors of Clostridial Collagenase H (ColH) as Pathoblocker Agents Microbial infections are a significant threat to public health and resistances are on the rise, so new antibiotics with novel modes of action are urgently needed. The extracellular zinc metalloprotease collagenase H (ColH) from Clostridium histolyticum is a virulence factor that catalyzes tissue damage, leading to improved host invasion and colonisation. Besides the major role of ColH in pathogenicity, its extracellular localisation makes it a highly attractive target for the development of new antivirulence agents. Previously, we had found that a highly selective and potent thiol prodrug (with a hydrolytically cleavable thiocarbamate unit) provided efficient ColH inhibition. We now report the synthesis and biological evaluation of a range of zinc‐binding group (ZBG) variants of this thiol‐derived inhibitor, with the mercapto unit being replaced by other zinc ligands. Among these, an analogue with a phosphonate motif as ZBG showed promising activity against ColH, an improved selectivity profile, and significantly higher stability than the thiol reference compound, thus making it an attractive candidate for future drug development. Special Issue (A & I)April 2019 Pseudomonas aeruginosa is an opportunistic pathogen and is a common cause of nosocomial infection, which causes a widerangeof infection, Two hundred and seventy eight samples were collected from different hospitals and private clinics in Waist province during the period from 15th September 2017 to the15th December 2017.Seventy one isolates were identification as Pseudomonas aeruginosa by culture characterized, biochemical tests, API20E .Sixty seven isolates were detected as Peudomonas aeruginosa by molecular methods of 16SrRNA gene.The polymerase chain reaction technique was used for screening, the(9) virulence genes (opr L, opr I, tox A, lasB,phzS ,exoS, phzM, phzH and nan1), the result showed that 67(100%) isolates were PCR positive for oprL and oprI. The determined of toxA gene that PCR positive for 56(83.6%). Another gene lasB were 65(97%) PCR positive. phzS gene were 61(91%) PCR positive. The result of PCR showed that 50(74.6%) isolates were PCR positive for exoS gene. The phzM gene in sixty seven isolates of Pseudomonas aeruginosa give PCR positive result in 36(53.7%).Results of phzH gene in Pseudomonas aeruginosa 32(47.8%).The nan1 gene detected in 67 isolates of Pseudomonas aeruginosa and percentage of PCR positive were 48(71.6%).In conclusion ,in studied the samples, still wounds are the common sites for Pseudomonas aeruginosa followed by ear and urine. 16SrRNA based PCR assay is highly accurate and reliable for identification of Pseudomonas aeruginosa.
https://www.researchgate.net/publication/323438432_Binding_Mode_Characterization_and_Early_in_Vivo_Evaluation_of_Fragment-Like_Thiols_as_Inhibitors_of_the_Virulence_Factor_LasB_from_Pseudomonas_aeruginosa
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(PDF) A spectral approach to numerical simulations of the ADM equations PDF | We present a numerical study of the Einstein equations, according to the Arnowitt-Deser-Misner (ADM) formalism, in order to simulate the dynamics... | Find, read and cite all the research you need on ResearchGate PDF Available A spectral approach to numerical simulations of the ADM equations Download file PDF Abstract We present a numerical study of the Einstein equations, according to the Arnowitt-Deser-Misner (ADM) formalism, in order to simulate the dynamics of gravitational fields. We took in consideration the original $3+1$ decomposition of the ADM equations, in vacuum conditions, in simplified geometries. The numerical code is based on spectral methods, making use of filtering (de-aliasing) techniques. The algorithm has been stabilized via an adaptive time-refinement, based on a procedure that checks self-consistently the regularity of the solutions. The accuracy of our numerical model has been validated through a series of standard tests. Finally, we present also a new kind of initial data that can be used for testing numerical codes. arXiv:1909.03055v1 [gr-qc] 6 Sep 2019 Noname manuscript No. (will be inserted by the editor) A spectral approach to numerical simulations of the ADM equations C. Meringolo 1 · S. Servidio 1 · P. V eltri 1 Received: date / Accepted: date Sommario W e present a numerical study of the Einstein equations, accor- ding to the Arnowitt-Deser-Misner (ADM) formalism, in order to simulate the dynamics of gravitational fields. We took in consider ation the original 3 + 1 decomposition of the ADM equations, in vacuum conditions, in simpli- fied geometries. The numerical code is based on sp ectral methods, making use of filtering (de-aliasing) techniques. The algo rithm has been stabilized via an adaptive time-refinement, based on a procedur e that checks self-consistently the regularity of the solutions. The accuracy of our n umerica l model has been validated through a series of standard tests. Finally , we present also a new kind of initial data that can b e used for testing numerical co des. Keywords Numerical relativity · ADM · numerical simulations 1 Introduction In last years, many different numerical evolution schemes for Einstein equa- tions have been developed and proposed, in order to address stability and ac- curacy problems that have interested the numerical relativity comm unity for decades. Some of these approaches have been tested on different spacetimes, and conclusions have been drawn based o n these tests. However, differences in results originate from many sources, including not only formulations of the equations, but also gauges, b oundary conditions, numerical methods and so on [1 – 17]. In this pap er we present a 2 + 1 formalism of the standard ADM C. Meringolo E-mail: [email protected] 1 Dipartimento di Fisica, Univ ersità della Calabria, I-87036 Cosenza, Italy Te l.:+39 0984 49 6138 Fa x: +39 0984 49 4401 2 C. Meringolo 1 et al. decomposition [18], in vacuum condition, in order to solve Einstein equations. Our numerical code is based up on a spectral appro ach and periodic b ounda- ry conditions. The la st ones are characteristic of homogeneous and localized regions of the space- time. W e use two different anti-aliasing filters in order to minimize the aliasing instability due to nonlinear terms, and we show how a ’smoothed’ filter leads to a more stable simulation than a truncated ’Heaviside’ filter. W e further stabilize the co de checking the right v alue of the time-step dt of integration via an adaptive time-refinement, based on a pro cedure that checks self-consisten tly the regularity of the solutions, called RS C condition . W e find a new solution of initial data that satisfies the constraint equations, and leads to s tanding waves of the metric tensor. These wav es a re sinusoidal for small amplitude of the perturbation, and b ecome even more asymmetrical as the amplitude increases. The accur acy of our numerical model has been valida- ted through a series of standard tests, like gauge wave tests and robust stability tests, as suggested by Alcubierre, Dumbser, Rezzolla et al. [19 – 22,24]. The co- de successfully passed various numerical tests, showing accuracy , stability and robustness. 2 F ormulation Throughout this paper, Latin indices are spatial indices and r un from 1 to 3, whereas Greek indices are spacetime indices and run from 0 to 3 . The basic equation is the vacuum Einstein equation: G µν = 0 . (1) T o solve Eq. (1) we start from the standard 3 + 1 for mulation of general relativity of Arnowitt, Deser, and Misner [25, 26], and write the line element as: ds 2 = − α 2 dt 2 + γ ij  dx i + β i dt  dx j + β j dt  , where α , β k and γ ij are the lapse function, the shift vector and the spa- tial metric, respectively [25, 26]. Using the 3+1 formalism, the Einstein equa- tion is split into the constraint equations and the ev olution equations. The Hamiltonian and momentum constraints are: R + K 2 − K ij K ij = 0 , (2a) D i  K ij − γ ij K  = 0 , (2b) where K ij , K , R and D i are the extrinsic curvature, the trace part of K ij , the scalar curvature of a 3D hypersurface and the covarian t derivative with respect of γ ij , r espectively. The set of equations (2) represent the initial data problem, discussed in detail in Ref. [23,36, 37]. The evolution equations for the spatial metric and the extrinsic curvature are, respectively, written as: ( ∂ t − L β ) γ ij = − 2 αK ij , (3a) A spectral approac h to numerical simu lations of the ADM equations 3 ( ∂ t − L β ) K ij = α  R ij − 2 K ik K k j + K K ij  − D i D j α. (3b) In what follows we will restrict to the case of zero shift ( β k = 0 ). The ADM evolution equations then reduce to: ∂ t γ ij = − 2 αK ij , (4a) ∂ t K ij = α  R ij − 2 K ik K k j + K K ij  − D i D j α. (4b) Finally , we need evolution equation for the lapse α , i.e., we need to choose a slicing condition. In the Bona-Massó (BM) formalism [27–30] the following slicing condition is used: ∂ t α = − α 2 f ( α ) K, (5) with f ( α ) > 0 but otherwise arbitrary [31–34]. 2.1 A 2+1 ADM formulation In this paper, we will study a simplified, reduced geometry. In particular, we now introduce a 2 + 1 decomposition, in vacuum conditions and zero shift. F or example, one can assume that at t = 0 the 3-dimensiona l metric and the extrinsic curvature are of the type: γ ij =   γ xx γ xy 0 γ yx γ yy 0 0 0 1   , K ij =   K xx K xy 0 K yx K yy 0 0 0 0   , (6) with the extra-condition that nothing dep ends of z : ∂ z γ ij = ∂ z K ij = 0 . (7) It is clear that these initial conditions imply that all the z − components of the spatial Ricci tensor R ij are zero: R zj = 0 , ∀ j. (8) This hold at t = 0 but conditions (6), (7) and (8) guarantee that the terms of the type R zj do not mix with the R xx , R xy and R yy ter ms during the time evolution. This happens for both the Ricci tenso r and for all the other dynamic variables. Then it is possible rewrite the evolution equations for 2 D quantities for- mally in the same way of (3), except that indices run over two possible values, that is ( i, j ) = x, y . T his proves that a 2 + 1 subcase is totally c onsistent with the full 3 + 1 case. 4 C. Meringolo 1 et al. 3 Numerical technique 3.1 Spectral method All of our numerical computations are carried out using pseudospectral me- thods [35]. A br ief outline of our metho d is as follows: given a system of partial differential equations ∂ t u ( x , t ) = f [ u ( x , t ) , ∂ i u ( x , t )] , where u is a collection of dynamical fields (i.e. γ ij , K ij , α ), the solution u ( x , t ) is expressed as a time-dependent, trunca ted linear combination u N ( x , t ) of spatial basis functions φ k ( x ) , k ∈ Z : u ( x , t ) ≃ u N ( x , t ) = n / 2 X k = − n / 2 e u k ( t ) φ k ( x ) . (9) Associated with the bas is functions is a set of N co llocation points x i . Gi- ven spectral coefficients e u k ( t ) , the function values at the collocation points u N ( x i , t ) are computed using Eq. (9). Conversely, t he spectral c oefficients are obtained by the inverse transform: e u k ( t ) = n/ 2 X i = − n/ 2 w i u N ( x i , t ) φ k ( x i ) , where w i are weights specific to the choice of basis functions and collocation points. Thus it is straightforward to transform between the sp ectral co efficients e u k ( t ) and the function v alues at the collocation points u N ( x i ) . Because the tests discussed here ar e periodic in all s patial dimensions, we use Fo urier basis functions φ k ( x ) = e i k · x . Eq. (9) then becomes: u N ( x , t ) = n / 2 X k = − n / 2 e u k ( t ) e i k · x . Note that in a periodic domain, it is easy to show that the above series is simply truncated to n = N/ 2 . Note also that the reality conditions gives e u k = e u ∗ − k . T o solve the differential equations, we ev aluate spatial derivatives analytically using the known deriv atives of the basis functions: ∂ i u N ( x , t ) = n / 2 X k = − n / 2 e u k ( t ) ∂ i e i k · x . F or smooth solutions, the spec tral approximation Eq. (9) converges exponen- tially (error ∼ e − λN for some λ > 0 which depends on the solution). This is much faster than the polynomial convergence ( error ∼ 1 /N p ) obtained using p th-order finite-differencing [38]. A spectral approac h to numerical simu lations of the ADM equations 5 3.1.1 The aliasing phenomenon and the anti-aliasing filters Let consider now the simplest poss ible nonlinearity , i.e. the product of two functions f ( x ) and g ( x ) in a one-dimensional problem, defined by their trun- cated Fourier series with N modes: f N ( x ) = m X p = − m e f p e ipx , g N ( x ) = m X q = − m e g q e iqx , (10) where e f p and e g q are the complex related Fourier coefficients. The product of two functions in the physical space, defined of a finite, periodic g rid, where therefore m = N/ 2 , becomes a convolution product in F ourier space, namely f ( x ) g ( x ) =  m X p = − m e f p e ipx  m X q = − m e g q e iqx  = m X m X q = − m e f p e g q e i ( p + q ) x . (11) It can be clearly seen that the product (11) contains high order harmonics re- spect to the tr uncated Fourier series of singles functions (10), which cannot be represented on the initial grid. They will contribute to the well-know aliasing error [39], since the F ourier transform of this pro duct gives: e Q k = Z f ( x ) g ( x ) e − ikx dx = ··· = X p + q = k e f p e f q , (12) where we have defined a single sum over some selected couplings, namely P p + q = k { ... } ≡ P p P q { ... } δ p + q,k . Now suppose that both f and g have all the harmonics, from − N/ 2 to N / 2 . One can immediately see how products like Eq. (12) proliferates energy into k > N/ 2 , causing the aliasing error and hence numerical instabilities. In order to eliminate instabilities due to aliasing in the quadratic nonlinear terms, it is then us eful to define a k ∗ in such a wa y that all coefficients with p, q, ... > k ∗ are ze ro. F or a quadratic nonlinearity of the type in Eq.s (11)–(12), it has been demo nstrated that is sufficient to filter out modes with k > k ∗ = 2 N/ 3 , instead of k ∗ = N/ 2 . This fully eliminates the aliasing instability (see e.g. [40]). In summary , the technique is very simple: on the final product it is enough to set e Q k = 0 for k > 2 N / 3 . In the case of the Einstein field equations, it is important to consider the very high nonlinea rity of the system. Let’s take for example Eq. (3b), where one has products o f the type: ∂ t K xx ∼ .... + 1 4 αγ y x ( ∂ y γ xx ) γ yy ( ∂ x γ y y ) + ... The above quantity has a nonlinearity of order 5 , which corresponds to a terrible convolution in the F ourier space. Following the abov e decomposition, indeed, for a generic quintic product, in 2D, one has to c onsider generally Q ( x ) = f 1 ( x ) f 2 ( x ) f 3 ( x ) f 4 ( x ) f 5 ( x ) . 6 C. Meringolo 1 et al. T aking the F ourier transforms, and applying the space-integral, one gets: e Q k = X p + q + l + h + n = k e f 1 ( p ) e f 2 ( q ) e f 3 ( l ) e f 4 ( h ) e f 5 ( n ) . It is easy to envision a process in which the above products produce immedia- tely high-order harmonics and therefore a prono unced aliasing instability. Because of the ab ove discussion, in this pap er, different values of k ∗ have been chosen, depending on the difficulty of the sim ula tion and on the initial conditions type. Generally, by filtering high F ourier modes, the price to pay is the loss of effective resolution (information). How ever, by suppressing this high- k ’s activity , the co des become more stable and a ccurate since the convo- lution in the quintic products does not push energy outside from the allowed k –space. W e will adopt Fast F ourier Transforms (FFT) [41] to compute spatial de- rivatives. F or any product (and in general for any variable), we filter out the highest harmonics using two types of filter Φ k ∗ ( k ) . We will have then: f N ( x ) = N/ 2 X k = − N/ 2 e f k e ikx Φ k ∗ ( k ) . A first truncated ’Heaviside’ filter is defined a s: Φ k ∗ ( k ) = 1 if | k | ≤ k ∗ , (13a) Φ k ∗ ( k ) = 0 if | k | > k ∗ , (13b) and a second smoothed filter is given by: Φ k ∗ ( k ) = e − a | ξ a | , (14) where ξ = | k | k ∗ and a = 30 . (grid-size), k ∗ = N/ 3 (typical quadratic nonlinearities), N / 4 and so on. 3.2 Runge-Kutta method F or our numerical tests we use a second-order Runge-K utta (RK) metho d [42]. Consider a function y ( t ) , with t ∈ [0 , + ∞ ) and F ( t, y ) a generic function in the Cauchy problem: ∂ t y ( t ) = F ( t, y ( t )) , y ( t 0 ) = y 0 . (15) Assuming the function y n know at the discrete time interval n , the idea is to write the function y n +1 at time n + 1 as linear combination of the form: y n +1 = y n + aK 1 ( t n , y n ) + bK 2 ( t n , y n ) + O ( ∆t 3 ) (16) A spectral approac h to numerical simu lations of the ADM equations 7 where K 1 = ∆t F ( t n , y n ) , K 2 = ∆t F ( t n + ϑ∆t, y n + ϕK 1 ) , ∆t is the time-step of integration and a, b, ϑ, ϕ are parameters. Using a Ta ylor expansion, it is easy to get: K 2 ≃ ∆t  F ( t n , y n ) + ϑ∆t ∂ t F    t n ,y n + ϕK 1 ∂ y F    t n ,y n  + O ( ∆t 3 ) . In Eq. (16) one obtains: y n + ∆t F ( t n , y n ) + 1 2 ∆t 2 ∂ t F    t n + 1 2 ∆t 2 ∂y F    y n = y n + a∆tF ( t n , y n )+ + bϕK 1 ∆t ∂ y F    y n . In order to o btain a second-order scheme, it must be a + b = 1 , bϑ = 1 / 2 and bϕ = 1 / 2 , while the parameter ϑ is free. Finally, with these substitutions, one has: y n +1 = y n +  1 − 1 2 ϑ  ∆t F ( t n , y n ) + 1 2 ϑ ∆t F ( t n + ϑ∆t, y n + ∆t F ( t n , y n )) . Choosing ϑ = 1 / 2 one obtains the second-order Runge-Kutta scheme: y n +1 = y n + ∆t F  t n + ∆t 2 , y n + F ( t n , y n ) ∆t 2  . 3.3 Running Stability Check (RSC) In numerical metho ds, the Courant-Friedric hs-Lewy (CFL) condition is a ne- cessary convergence condition for the solution of certain partial differential equations problems [43], in particular for explicit time integration schemes. Suppose to describ e the motion of a wave traveling through a discrete spatial grid with speed v . O ne has to choose a length interv al ∆x of spatial grid and a time step integration ∆t , but these two quantities are not really independent: in order to obtain “go od results”, the CFL condition impo ses that it must be ∆t = f ( ∆x ) . Schematically, the condition says that if a generic wave is moving across a discrete s patial grid, then the time step must b e less than step and “space step” a re tight related, and in particular the “space step” (i.e. the grid point separation) fix an upper limit for the time step: if the second one is reduced, the first one must also decrease. For a simple one-dimensional propagating fluctuation, the CFL condition is given by ∆t < C ∆x v , where C is called Courant num ber, and in general is chosen to be 1 / 2 , in order to b etter satisfy the condition. A general criterion for determination of the time-step integration dt is necessary in order to maximize the efficiency o f the code and avoid instabilities, especially in the unknown case of the ADM equations. F or 8 C. Meringolo 1 et al. this purpose, we will elaborate the CFL idea, in a more general sense. For any ADM dynamic variable, let say A ij , there is an evolution equation ∂A ij ∂t ≃ ∆A ij ∆t , (17) from Eq. (17) one can estimate the time step relative to the dynamical varia- bles A ij as T ( A ij ) d = A ij ∂ t A ij , and one obtains resp ectively for the metric, the extrinsic curvature and the lapse T ( γ ij ) d = − γ ij , T ( K ij ) d = K ij α  R ij − 2 K ik K k j + K K ij  − D i D j α , T ( α ) d = − α α 2 f ( α ) K . It is evident that variables that have a large time-deriv ative (they are fluc- tuating fast), have a small related T (less stable). Analog ously , small time derivatives (or very large functions) lead to high T (more stable region). Fur- thermore, from our preliminary tests, it turns out that a small T anticipate the typical code-crashing. The technique hence consist of an interesting monitoring during the evolution of the code, together with the violation of the AMD con- straints. Note also that the ab ove technique it might provide a general guess for the choice of the in tegr ation time step in the second-order Runge-Kutta technique. F r om the ab ove reasoning, since there are several control times T , one can choose the time step constrained to the following general expression: ∆t < C min {T j } (19) where C is the Coura nt num ber and index j run over all the ADM dynamic variables. This method is called Running Stability Check (RSC), since it com- putes continuously in time the minimum time step, controlling all the possible merical simulation, even in a self-adjusting fashion. Essentially, whenever the characteristic times T becomes to o small, the code reduces its time step of the second order Runge-Kutta. This metho d is called adaptive time refine- ment and leads to an improvement of stability , as will be shown in the next testbeds. 4 Standard numerical testb eds In this Section we will perform new direct numerical simulations of the gravi- tational dynamics. We will explore all the standard numerical testbeds, sugge- sted by Alcubierre, Dumbser, Rezzolla et al. [19 – 23], in order to validate our code. For each test, we will check accuracy by inspecting the conserved quan- tities of the ADM formalism, applying the running stability check and v arying A spectral approac h to numerical simu lations of the ADM equations 9 the anti-aliasing filters. An adaptive Runge-Kutta metho d will b e employed in order to further ensure numerical stability. Aft er these fundamental tests, we show a new possible initial condition that leads to standing nonlinear waves. 4.1 Robust stability test The robust stability testbed efficiently reveals exponentially growing modes which otherwise might be masked beneath a strong initial signal for a con- siderable evolution time. It is based up on small random p erturbations of Minkowski space. As suggested by Alcubierre et al. in Ref. [19], the starting configuration is a flat Minkowski metric ds 2 = − dt 2 + dx 2 + dy 2 . tions, distributed over every variable ( γ ij , K ij , α ). The idea is that if a code cannot stably evolve a random noise then it wil l be unable to evolve a real initial data. In this test, the initial metric has b een initialized as γ ij = η ij + ε ij , (20 ) where ε ij is the random p erturbation (small random numbers gener ated via classical algorithms [42]). The a mplitude of the p erturbation is small enough so that the evolution remains in the linear regime, unless instabilities arise. This corresp onds to the following choice: ε ∈  − 10 − 10 , +10 − 10  . In all robust stability test the harmonic gauge was used [i.e., f ( α ) = 1 in the slicing equation (5)]. W e chose a spatial domain x, y ∈ [0 , 1] , a spatial grid N x × N y = 64 2 , dx = dy = 2 − 6 and a dt = 2 · 10 − 3 . Since the initial data violate the constraints, any instability can be expected to lead to an exp onential growth of constraints. In order to stabilize the code, the anti-aliasing filt er, described by Eq.s (13) and (14), can be used here to show whether it can improve the stability of the code. The test runs for a time of t = 10 (corresp onding to 10 crossing times) or until the code crashes, and the performance has been monitored by looking at the evolution of the ADM constrain ts in time, i.e. by outputting the L 2 norm of the Hamiltonian constra int and the momentum constraints once per crossing. W e define this measure as: u u t R Ω ε 2 dΩ p | γ | R Ω dΩ p | γ | , (21) where ε denotes the local error of each of the ADM quantities, i.e., Hamiltonian H and momentum constraints M i , while dΩ p | γ | is the volume element. 10 C. Meringolo 1 et al. 10 -8 10 -6 10 -4 10 -2 10 0 ||Hamiltonian|| 2 Filter = N/5 1 100 200 300 400 500 ||Hamiltonian|| 2 Crossing time ’Heaviside’ filter Smoothed filter Figura 1 Left: Hamiltonian constraint vs time for Mi nkowski flat space with random noise as perturbation, respectively unfiltered, with k ∗ = N/ 2 , k ∗ = N/ 3 and k ∗ = N/ 5 ’Heaviside’ anti-aliasing filter. These runs have been summarized in T able 1 as RUN 1 , RUN 2 , RUN 3 and RUN 4 . Right: L 2 error s of Hamiltonian constraint for the same test using a k ∗ = N/ 5 for both anti-aliasing filters described by Eq.s (13) and (14), and dt = 5 · 10 − 4 . Note that the smoothed filter better stabilize the co de. The evolution is carried out for t = 500 , and these runs are reported in T able 1, as RUN 5 and RUN 6 . As discussed in Section 3.1.1, since the ADM equations are strongly non- linear, the k ∗ = 2 N/ 3 filter is not enough and then different filter was te- sted. The left panel of Fig. 1 rep orts the evolution of the L 2 norm of the Hamiltonian constraint, for the different filters (respectively unfiltered, with k ∗ = N/ 2 , k ∗ = N/ 3 and k ∗ = N / 5 filter) using the ’Heaviside’ filter described by Eq. (13). These runs have been summarized in T able 1 as RUN 1 , RUN 2 , RUN 3 and RUN 4 . It is obvious that the anti-aliasing filter improves noticeably the stability and the accuracy of the code. In order to show the improv ement of the smoothed filter and the robustness of the code, a last test with a k ∗ = N/ 5 using both filters describe d by Eq.s (13) and (14) and a time step of dt = 5 · 10 − 4 has been performed, for 500 cros sing times. The L 2 norms of the Hamiltonian constraint are shown in the right panel of Fig 1. The test shows that the Hamiltonian remain essentially constant after a long time of simulation using the ’Heaviside’ filter, while slightly decrease using the smoo thed filter, emphasizing the go odness of our approach. These runs are rep orted in Table 1, as RUN 5 and RUN 6 . 4.2 Gauge wave test The gauge-wave is a class ical numerical recipe that tests how a code handles gauge dynamics. As suggested again by Ref. [19], the metric is giv en by: ds 2 = − H ( x, t ) dt 2 + H ( x, t ) dx 2 + dy 2 , (22) where H ( x, t ) d = 1 − A sin  2 π ( x − t )  describes a sinusoidal gauge wave of amplitude A , propagating along the x -axis. Since derivatives are zero in the y direction, the problem is essentially one-dimensional. The metric (22) implies A spectral approac h to numerical simu lations of the ADM equations 11 10 -4 10 -2 10 0 10 2 10 4 10 6 10 8 0 1 2 3 4 5 6 7 8 RSC conditions Crossing time τ (K xx ) τ ( γ xx ) τ ( α ) dt 10 -4 10 -2 10 0 10 2 10 4 10 6 10 8 1 100 200 300 400 500 RSC conditions Crossing time τ (K xx ) τ ( γ xx ) τ ( α ) dt Figura 2 Small amplitude gauge wave test. Left: RSC conditions without adaptive time refinement: the code crashes at t ≃ 8 . Right: RSC conditions with adaptive time refinement and C = 1 / 4 : the code remain stable until t = 500 . For the symmetry of the problem, only T ( K xx ) , T ( γ xx ) , T ( α ) have been reported. The full black line represents the time step of the simulation. These runs are reported in T able 1 as RUN 7 and RUN 8 . β i = 0 , and K xx = − ∂ t γ xx 2 α . F or the metric γ ij and the extrinsic curvature K ij one obtains respectively: γ ij =  1 − A sin [2 π ( x − t )] 0 0 1  , K ij =   − Aπ cos [2 π ( x − t )] p 1 − A sin [2 π ( x − t )] 0 0 0   and one can easily demonstrates that these satisfy the initial data constraints in Eq. (2). This gauge-wave test was performed twice: once with a small amplitude A in order to take the system in a linear regime and a second test with a very large amplitude A , as suggested by Dumbser et al. [20]. F or the first run, a small amplitude A = 10 − 2 and a k ∗ = N/ 3 ’Heaviside’ filter is used. We chose a spatial domain x, y ∈ [0 , 1] , a spatial grid N x × N y = 64 2 , dx = dy = 2 − 6 , a dt = 5 · 10 − 3 and the harmonic slicing ( f ( α ) = 1 ). However, in order to check the RS C conditions (see Section 3.3) the test was performed twice: first one with a stationary time step, and a second one with an a daptive time refinement. These runs are summarized in Table 1 as RUN 7 and RUN 8 . Fig. 2 (left) shows the time evolution of the RSC conditions in time. Note that for the symmetry of the pr oblem, only T ( K xx ) , T ( γ xx ) , T ( α ) have been reported. The full black line represents the time step of the simulation. One can see that when one RSC co ndition becomes smaller than the time step, instabilities arises and the co de crashes. In the second test, it has been used an adaptive time refinement with C = 1 / 4 , and the run is carried out until 500 crossing times. The code is much more stable thanks to the fact that the time step remain ever below the RSC co nditions, as shown in Fig. 2 (right). Even if a code remains stable for long time, the test is meaningless without a good comparison between the numerical experiment an the analytic solution (if there is any). In Fig. 3 ( left) we compare the wa ve-form of γ xx , at t = 500 , with the exact solution. Here we use dt = 10 − 3 . In Fig. 3 (right) we report 12 C. Meringolo 1 et al. 0.99 0.995 1 1.005 1.01 0 0.2 0.4 0.6 0.8 1 x Numerical γ xx Exact solution 0 ⋅ 10 0 2 ⋅ 10 -5 4 ⋅ 10 -5 6 ⋅ 10 -5 8 ⋅ 10 -5 1 ⋅ 10 -4 1 ⋅ 10 -4 0 0.2 0.4 0.6 0.8 1 x Error in γ xx (t=500) Figura 3 Left: Comparison of the wave form of γ xx with the exact solution, for a small amplitude perturbation A − 2 , at t = 500 . Right: Difference between n umerical γ xx and exact result at t = 500 . This test is reported in Table 1 as RUN 9 . -15 -10 -5 0 5 10 15 20 25 0 0.2 0.4 0.6 0.8 1 x K (t = 1.2) Exact solution -15 -10 -5 0 5 10 15 20 25 0 0.2 0.4 0.6 0.8 1 x K (t = 1.2) Exact solution Figura 4 Gauge-wave test case with amplitude A=0.9. Comparison of the wav e form of trace of the extrinsic curvature K in nonlinear regime without filter (left) and with k ∗ = N/ 3 smoothed filter (right) with the exact solution at t = 1 . 2 . The anti-aliasing filter leads to an improved wa ve form of K . These runs are summarized in T able 1 as RUN 10 and RUN 11 . the numerical error, in order to show the good consistency of the code, even if a k ∗ = N/ 3 ’Heaviside’ filter is used. One can see that the error is two order of magnitude less than the amplitude of the wa ve. This test is reported in T able 1 as RUN 9 . Regarding the high per turbation amplitude, we have chosen at first A = 0 . 9 , with a square spatial grid of n = 128 points and dt = 10 − 3 . The other parameters are the same as used in the small amplitude case, including the slicing gauge. Again we have performed two experiments: first without an ti- aliasing filter and second with k ∗ = N/ 3 smoothed filter defined in Eq. (14). A comparison between the nonlinear wa veforms of the trace of the extrinsic curvature K in both cases has been plotted in Fig. 3. As it can be seem there is a go od improvement with the anti-aliasing filter. O ne can observe, indeed, an excellent agreement between the exact and the numerical solutions. In the unfiltered case, instead, numerical instabilities aris e, as reported in the left panel of figure 3. These runs are reported in Table 1 as RUN 10 and RUN 11 , respectively. A second test in nonlinear regime ha s been perfor med, this time with a A spectral approac h to numerical simu lations of the ADM equations 13 ||x-momentum|| 2 Crossing time ’Heaviside’ filter Smoothed filter -50 -30 -10 10 30 50 0 0.2 0.4 0.6 0.8 1 x K (t = 10) Exact solution Figura 5 Left: Evolution of x − momentum constrain t for the gauge wa ve test with high amplitude A = 0 . 96 using different filters described by Eq.s (13,14); with the ’Heaviside’ filter the x − momentum constraint gro ws up and the code crashes, while with the smoothed filter the ADM constraint slightly decrease and the code stabilizes. The evolution has been carried out for t = 10 crossing times. These runs are reported in T able 1 as RUN 12 and RUN 13 . Right: Comparison of the wave form of the trace of the extrinsic curv ature K with exact result and A = 0 . 96 at t=10 using the smoothed filter. Note the good agreement despite the very high v alue of A . larger perturbation A = 0 . 96 . Now a goo d choice for the filter has found to be k ∗ = N/ 2 . 5 . In order to test the different anti-aliasing filters we p erformed the second one using the smoothed filter defined in Eq. (14). The time evolution of the x − momentum constraint for both tests is rep or- ted in Fig. 5 (left), showing that the smo othed filter stabilize the co de, while the ’Heaviside’ filter leads to a gro wing of the ADM constraints and the code crashes. These runs are r eported in Table 1 as RUN 12 and RUN 13 . In Fig. 5 (right) we report the waveform of K at time t = 10 , which is in excellent agreement with the exact solution. It is important to emphasize that, with this amplitude, even if the system is in a very nonlinear regime, is still stable, thanks to the smoothed anti-aliasing filter. 4.3 A new possible initial condition: the standing waves Here we propose a new initial da ta that satisfies Eq.s (2). Supp ose an initial Minkowski flat space, which means zero curvature and where Ricci tensor vanishes ( R = 0 ). The constraint equations reduce to K xx K yy − ( K x y ) 2 = 0 , (23a) D y K xy − D x K yy = 0 , (23b) D x K xy − D y K xx = 0 . (23c) The above represent the Hamiltonian and the tw o momentum constraints, respectively. Note that the Hamiltonian constraint (23a) requires that the 14 C. Meringolo 1 et al. 10 -19 10 -16 10 -7 10 -4 10 -1 0 20 40 60 80 100 L2 errors Crossing time Hamiltonian Momentum x 10 -19 10 -16 10 -13 10 -10 0 20 40 60 80 100 L2 errors Crossing time Hamiltonian Momentum x Figura 6 Temporal evolution of the L 2 norm of Hamiltonian and x − momentum co nstraint for standing waves test. Left: without filter anti-aliasing: the Hamiltonian constraint remains constant, the x − momentum constrain t grows up while the y − momentum is zero. Ri ght: with k ∗ = N/ 3 smoothed filter: the Hamiltonian constraint remains essentially unchanged while the x − momentum constrain t is constant. The evolution is carried out for t = 100 crossing determinant of K ij v anishes. The initial per turbation can be chosen only for the extrinsic curvature K ij , with an unperturb ed metric tensor γ ij . With this choice, one has: γ ij = η ij , K ij =  Asin (2 πx ) 0 0 0  , (24) which satisfies the set of constr aints in Eq. (23). But unlike the previo us gauge waves, this condition does not lead to a wave propagating in space but to standing waves of the metric. In Fig. 7 w e rep ort the time evolution of the metric, for se veral tests. F or the first test, a small amplitude A = 10 − 1 and no anti-aliasing filter has been used, while the run is ca rried out until 100 crossing times. The others parameters used are: a spatial domain x, y ∈ [0 , 1] , a spatial grid N x × N y = 64 2 , dx = dy = 2 − 6 , a dt = 10 − 3 and the ha rmonic slicing ( f ( α ) = 1 ). W e have carried out a second test with same parameters as before, except a k ∗ = N/ 3 smoothed filter ha s been used. It is evident that the filter impr oves the stability . These r uns are reported in Table 1 as RUN 14 and RUN 15 . Fig. 6 shows that the Hamiltonian constraint remain constant in b oth cases, but the x − momentum constraint (for the symmetry of the problem the y − momentum is zero) grows without filter and remains constant with the k ∗ = N/ 3 filter. In order to see nonlinear effects, a s econd high amplitude test has b een performed, with A = 8 , a spa tial grid with n = 128 p oints and a k ∗ = N/ 3 filter. All the other parameters have been chose as in the previous test. The metric tensor starts to b ounce, and is asy mmetric since it cannot b ecome negative on one side. Fig. 7 (left) shows a section of γ xx for a sma ll amplitude A = 0 . 1 , while in Fig. 7 (right) amplitude of A = 1 , 5 , 8 ar e performed. Again, this test was performed twice: a first test using the standard trun- cated filter described by eq. (13) and a second one in order to emphasize the A spectral approac h to numerical simu lations of the ADM equations 15 0.98 0.985 0.99 0.995 1 1.005 1.01 1.015 1.02 0 0.2 0.4 0.6 0.8 1 x A = 0.1 0 2 4 10 12 0 0.2 0.4 0.6 0.8 1 x A = 1 A = 5 A = 8
https://www.researchgate.net/publication/335712973_A_spectral_approach_to_numerical_simulations_of_the_ADM_equations
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A seasonal indoor and outdoor pool, tennis courts and a well-equipped gym are also available. Grand Skylight International Hotel ***** (in Ganzhou , distanced approximately 210 km) Grand Skylight International Hotel is a luxurious 5-star hotel located in the Golden Business District of Ganzhou, 200 metres from Huangjin Square. JJ Inns - Metro Supermarket *** (in Nanchang , distanced approximately 230 km) JJ Inns - Metro Supermarket is a 6-minute walk from the train station, providing convenient access to transportation. The inn offers air-conditioned rooms with free internet and en suite bathrooms. SSAW Hotel Nanchang **** (in Nanchang , distanced approximately 230 km) SSAW Hotel Nanchang is located in the city centre, a 5-minute walk from Bayi Square. It offers modern accommodation with sauna facilities, free parking and rooms with free internet. 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BG 2.47: Chapter 2, Verse 47 – Bhagavad Gita, The Song of God – Swami Mukundananda BG 2.47: You have a right to perform your prescribed duties, but you are not entitled to the fruits of your actions. … Commentary: This is an extremely popular verse of the Bhagavad Gita, so much so that even most school children in India are familiar with it. It offers … Bhagavad Gita: Chapter 2, Verse 47 karmaṇy-evādhikāras te mā phaleṣhu kadāchana mā karma-phala-hetur bhūr mā te saṅgo ’stvakarmaṇi karmaṇi— in prescribed duties;eva— only;adhikāraḥ— right;te— your;mā— not;phaleṣhu— in the fruits;kadāchana— at any time;mā— never;karma-phala— results of the activities;hetuḥ— cause;bhūḥ— be;mā— not;te— your;saṅgaḥ— attachment;astu— must be;akarmaṇi— in inaction karmany-evadhikaras te ma phaleshu kadachana ma karma-phala-hetur bhur ma te sango ’stvakarmani Translation BG 2.47:You have a right to perform your prescribed duties, but you are not entitled to the fruits of your actions. Never consider yourself to be the cause of the results of your activities, nor be attached to inaction. Commentary This is an extremely popular verse of the Bhagavad Gita, so much so that even most school children in India are familiar with it. It offers deep insight into the proper spirit of work and is often quoted whenever the topic of karm yogis discussed. The verse gives four instructions regarding the science of work: 1) Do your duty, but do not concern yourself with the results. 2) The fruits of your actions are not for your enjoyment. 3) Even while working, give up the pride of doership. 4) Do not be attached to inaction. Do your duty, but do not concern yourself with the results.We have the right to do our duty, but the results are not dependent only upon our efforts. A number of factors come into play in determining the results—our efforts, destiny (our past karmas), the will of God, the efforts of others, the cumulative karmas of the people involved, the place and situation (a matter of luck), etc. Now if we become anxious for results, we will experience anxiety whenever they are not according to our expectations. So Shree Krishna advises Arjun to give up concern for the results and instead focus solely on doing a good job. The fact is that when we are unconcerned about the results, we are able to focus entirely on our efforts, and the result is even better than before. A humorous acronym for this is NATO or Not Attached to Outcome. Consider its application to a simple everyday activity such as playing golf. When people play golf, they are engrossed in the fruits—whether their score is under par, over par, etc. Now if they could merely focus on playing the shots to the best of their ability, they would find it the most enjoyable game of golf they have ever played. Additionally, with their complete focus on the shot being played, their game would be raised to a higher level. The fruits of your actions are not for your enjoyment.To perform actions is an integral part of human nature. Having come into this world, we all have various duties determined by our family situation, social position, occupation, etc. While performing these actions, we must remember that we are not the enjoyers of the results—the results are meant for the pleasure of God. The individual soul is a tiny part of God (verse 15.7), and hence our inherent nature is to serve him through all our actions. dāsa bhūtamidaṁ tasya jagatsthāvara jangamam śhrīmannārāyaṇa swāmī jagatāṁprabhurīśhwaraḥ(Padma Puran)[v40] “God is the Master of the entire creation; all moving and non-moving beings are his servants.” Material consciousness is characterized by the following manner of thoughts, “I am the proprietor of all that I possess. It is all meant for my enjoyment. I have the right to enhance my possessions and maximize my enjoyment.” The reverse of this is Spiritual consciousness, which is characterized by thoughts such as, “God is the owner and enjoyer of this entire world. I am merely his selfless servant. I must use all that I have in the service of God.” Accordingly, Shree Krishna instructs Arjun not to think of himself as the enjoyer of the fruits of his actions. Even while working, give up the pride of doership.Shree Krishna wants Arjun to give up kartritwābhimān, or the ego of being the doer. He instructs Arjun never to chase after preconceived motives attached to his actions nor consider himself as the cause of the results of his actions. However, when we perform actions, then why should we not consider ourselves as the doers of those actions? The reason is that our senses, mind, and intellect are inert; God energizes them with his power and puts them at our disposal. As a result, only with the help of the power we receive from him, are we able to work. For example, the tongs in the kitchen are inactive by themselves, but they get energized by someone’s hand, and then they perform even difficult tasks, such as lifting burning coal, etc. Now if we say that the tongs are the doers of actions, it will be inaccurate. If the hand did not energize them, what would they be able to do? They would merely lie inert on the table. Similarly, if God did not supply our body-mind-soul mechanism with the power to perform actions, we could have done nothing. Thus, we must give up the ego of doing, remembering that God is the only source of the power by which we perform all our actions. All the above thoughts are very nicely summarized in the following popular Sanskrit verse: yatkṛitaṁ yatkariṣhyāmi tatsarvaṁ na mayā kṛitam tvayā kṛitaṁ tu phalabhuk tvameva madhusūdana[v41] “Whatever I have achieved and whatever I wish to achieve, I am not the doer of these. O Madhusudan, you are the real doer, and you alone are the enjoyer of their results.” Do not be attached to inaction.Although the nature of the living being is to work, often situations arise where work seems burdensome and confusing. In such cases, instead of running away from it, we must understand and implement the proper science of work, as explained by Shree Krishna to Arjun. However, it is highly inappropriate if we consider work as laborious and burdensome, and resort to inaction. Becoming attached to inaction is never the solution and is clearly condemned by Shree Krishna.
https://www.holy-bhagavad-gita.org/chapter/2/verse/47?fbclid=IwAR2ptVawpiuoIVkrjhBzQpW8-ezryRi8yPJzMA6WRFHsGJho5botNh-BFAo%2Fte%2Fte%2Fte%2Fta%2Fhi%2Fta
IJMS | Free Full-Text | Mechanisms and Treatment of Light-Induced Retinal Degeneration-Associated Inflammation: Insights from Biochemical Profiling of the Aqueous Humor Ocular inflammation contributes to the pathogenesis of blind-causing retinal degenerative diseases, such as age-related macular degeneration (AMD) or photic maculopathy. Here, we report on inflammatory mechanisms that are associated with retinal degeneration induced by bright visible light, which were revealed while using a rabbit model. Histologically and electrophysiologically noticeable degeneration of the retina is preceded and accompanied by oxidative stress and inflammation, as evidenced by granulocyte infiltration and edema in this tissue, as well as the upregulation of total protein, pro-inflammatory cytokines, and oxidative stress markers in aqueous humor (AH). Consistently, quantitative lipidomic studies of AH elucidated increase in the concentration of arachidonic (AA) and docosahexaenoic (DHA) acids and lyso-platelet activating factor (lyso-PAF), together with pronounced oxidative and inflammatory alterations in content of lipid mediators oxylipins. These alterations include long-term elevation of prostaglandins, which are synthesized from AA via cyclooxygenase-dependent pathways, as well as a short burst of linoleic acid derivatives that can be produced by both enzymatic and non-enzymatic free radical-dependent mechanisms. The upregulation of all oxylipins is inhibited by the premedication of the eyes while using mitochondria-targeted antioxidant SkQ1, whereas the accumulation of prostaglandins and lyso-PAF can be specifically suppressed by topical treatment with cyclooxygenase inhibitor Nepafenac. Interestingly, the most prominent antioxidant and anti-inflammatory benefits and overall retinal protective effects are achieved by simultaneous administrating of both drugs indicating their synergistic action. Taken together, these findings provide a rationale for using a combination of mitochondria-targeted antioxidant and cyclooxygenase inhibitor for the treatment of inflammatory components of retinal degenerative diseases. Background: Mechanisms and Treatment of Light-Induced Retinal Degeneration-Associated Inflammation: Insights from Biochemical Profiling of the Aqueous Humor by Dmitry V. Chistyakov 1,* , Viktoriia E. Baksheeva 1 , Veronika V. Tiulina 1,2 , Sergei V. Goriainov 3 , Nadezhda V. Azbukina 4 , Olga S. Gancharova 1,4 , Eugene A. Arifulin 1 , Sergey V. Komarov 2 , Viktor V. Chistyakov 3 , Natalia K. Tikhomirova 1 , Andrey A. Zamyatnin, Jr. 1,5 , Pavel P. Philippov 1 , Ivan I. Senin 1 , Marina G. Sergeeva 1 and Evgeni Yu. Zernii 1,5,* 1 Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia 2 Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 109472 Moscow, Russia 3 SREC PFUR Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow Russia 4 Faculty of Bioengineering and Bioinformatics, Moscow Lomonosov State University, 119234 Moscow, Russia 5 Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia * Authors to whom correspondence should be addressed. Int. J. Mol. Sci. 2020 , 21 (3), 704; https://doi.org/10.3390/ijms21030704 Received: 4 January 2020 / Accepted: 17 January 2020 / Published: 21 January 2020 (This article belongs to the Special Issue Retinal Degeneration: From Pathophysiology to Therapeutic Approaches ) Abstract : Ocular inflammation contributes to the pathogenesis of blind-causing retinal degenerative diseases, such as age-related macular degeneration (AMD) or photic maculopathy. Here, we report on inflammatory mechanisms that are associated with retinal degeneration induced by bright visible light, which were revealed while using a rabbit model. Histologically and electrophysiologically noticeable degeneration of the retina is preceded and accompanied by oxidative stress and inflammation, as evidenced by granulocyte infiltration and edema in this tissue, as well as the upregulation of total protein, pro-inflammatory cytokines, and oxidative stress markers in aqueous humor (AH). Consistently, quantitative lipidomic studies of AH elucidated increase in the concentration of arachidonic (AA) and docosahexaenoic (DHA) acids and lyso-platelet activating factor (lyso-PAF), together with pronounced oxidative and inflammatory alterations in content of lipid mediators oxylipins. These alterations include long-term elevation of prostaglandins, which are synthesized from AA via cyclooxygenase-dependent pathways, as well as a short burst of linoleic acid derivatives that can be produced by both enzymatic and non-enzymatic free radical-dependent mechanisms. The upregulation of all oxylipins is inhibited by the premedication of the eyes while using mitochondria-targeted antioxidant SkQ1, whereas the accumulation of prostaglandins and lyso-PAF can be specifically suppressed by topical treatment with cyclooxygenase inhibitor Nepafenac. Interestingly, the most prominent antioxidant and anti-inflammatory benefits and overall retinal protective effects are achieved by simultaneous administrating of both drugs indicating their synergistic action. Taken together, these findings provide a rationale for using a combination of mitochondria-targeted antioxidant and cyclooxygenase inhibitor for the treatment of inflammatory components of retinal degenerative diseases. Keywords: ocular inflammation ; light-induced retinal damage ; age-related macular degeneration ; oxidative stress ; polyunsaturated fatty acids ; oxylipins ; mitochondria-targeted antioxidant ; SkQ1 ; non-steroidal anti-inflammatory drugs ; Nepafenac Graphical Abstract 1. Introduction Inflammation is implicated in the etiology and progression of a number of blind-causing retinal degenerative diseases. Normally, the retina represents an immune-privileged zone that is separated by the inner and outer blood-retinal barriers that formed by retinal pigment epithelium (RPE) cells and microvascular endothelial cells, respectively [ 1 , 2 ]. However, retinal degenerative conditions associated with environmental, age-related, vascular, metabolic, and/or genetic factors may deteriorate these barriers and, thereby, contribute to the propagation of intraocular inflammation affecting the retina [ 1 ]. Oxidative stress plays a critical role in triggering retinal degeneration and intraocular inflammation. Photoreceptor and RPE cells generate high levels of reactive oxygen species (ROS) due to constant exposure to light and the presence of multiple photosensitizer molecules. In addition, extremely high oxygen consumption and metabolic rates characterize the retina, which underlie its high susceptibility to mitochondrial oxidative stress [ 1 , 3 ]. Oxidative stress and inflammation contribute to the development of age-related macular degeneration (AMD), diabetic retinopathy, retinopathy of prematurity, and retinitis pigmentosa [ 1 , 4 ]. For instance, pathological extracellular deposits (the so-called drusen) that are found in the retina of AMD patients contain byproducts of active inflammation and complement activation, together with products of lipid peroxidation [ 5 , 6 ]. Intraocular inflammation and macular edema can also be of iatrogenic origin, representing a complication of intraocular surgery and laser procedures. Without treatment, these complications can promote generalized breakdown of the blood-retinal barrier and irreversible retinal damage [ 7 ]. Light-induced retinal degeneration (LIRD) is a major driving force of photic maculopathy (light maculopathy, light-induced retinopathy), another common condition that shares many features with the above-mentioned ocular diseases [ 8 ]. Being conveniently simulated in animals, LIRD models are commonly employed for studies of pathogenesis and trailing of therapeutic approaches with respect to these diseases [ 9 ]. Spontaneous photochemical damage to the retina can be induced, for instance, by intensive light exposure from ophthalmological illuminators [ 10 , 11 , 12 ]. As an aggravating factor, excessive light illumination of the retina contributes to AMD and other retinal degenerative disorders by inducing the apoptosis of photoreceptors and other pathological hallmarks [ 8 , 13 ]. LIRD also resembles retinal degenerative diseases in terms of the pathogenetic roles of oxidative stress and inflammation. Prolonged illumination of the retina with visible light induces photochemical reactions in photoreceptors and RPE cells, yielding an accumulation of ROS and the oxidation of lipids and proteins [ 3 , 14 , 15 ] characteristic to AMD and other degenerative retinopathies [ 8 , 16 ]. Furthermore, LIRD might induce breakage of the blood-retinal barrier thereby promoting leukocyte infiltration and macular edema [ 14 , 17 ], and these signs are also can be found in AMD patients [ 18 , 19 ]. The exact mechanisms underlying induction and resolution of inflammation associated with degenerative retinal diseases remain mostly unspecified. The development of inflammation in AMD, diabetic retinopathy, retinitis pigmentosa, retinopathy of prematurity, and glaucoma seems to be regulated by interleukin-1 (IL-1) family members, as well as tumor necrosis factor alpha (TNF-α) and its counterpart interleukin-10 (IL-10) [ 20 , 21 , 22 ]. Consistently, the expression levels of interleukin-1 beta (IL-1β) and TNF-α were found to be altered in animal models of LIRD [ 23 , 24 ]. There are evidences that polyunsaturated fatty acids (PUFAs)-derived lipid mediators, such as oxylipins and resolvins, control the inflammatory component of retinal degenerative diseases. For instance, arachidonic acid (AA)-derived oxylipins, prostaglandins (PGs), were shown to participate in the pathogenesis of AMD and diabetic retinopathy [ 25 ]. Generally, the biosynthesis of oxylipins occurs via enzymatic pathways that involve cyclooxygenases (COX), lipoxygenases (LOX), or cytochrome P450 monooxygenases (CYP), and prostaglandins are generated in a COX-dependent pathway [ 26 ]. Consistently, nonsteroidal anti-inflammatory drugs (NSAIDs) that represent COX inhibitors were suggested for the treatment of AMD, diabetic retinopathy, and macular edema [ 27 ]. The increased expression levels of retinal COX-2 was also observed in LIRD, pointing on similar mechanisms of triggering inflammation [ 23 , 24 ]. Notably, certain oxylipins are synthesized via the non-enzymatic pathway due to the oxidation of PUFAs by free radicals. The highest content of PUFAs, particularly DHA and AA, characterize the retina and, therefore, it is extremely vulnerable to lipid peroxidation yielding corresponding specific oxylipins [ 16 , 28 ]. For instance, LIRD is associated with a pronounced elevation in the retinal concentration of oxylipin 8-iso-prostaglandin F2 alpha (8-iso-PGF 2α ), representing a product of free radical oxidation of AA independent of COX pathways [ 29 , 30 ]. In this case, the retina was also found to contain high amounts of hydroxyoctadecadienoic acids (HODEs), linoleic acid (LA)-derived oxylipins, which can be biosynthesized by enzymatic and non-enzymatic pathways [ 29 ]. Thus, oxylipins can be regarded as appropriate biomarkers that respond to both retinal inflammation and oxidative stress. Intraocular inflammation and oxidative stress associated with retinal degenerative diseases can be conveniently monitored by analyzing aqueous humor (AH) that is responsible for the nutrition of avascular structures of the eye. It is produced by active secretion from the non-pigmented epithelium of the ciliary body and can freely diffuse into the posterior cavity to wet the retina [ 31 , 32 ]. Similarly to the retina, AH is separated by the blood-AH barrier and, under normal conditions, it exhibits antioxidant properties and suppresses both innate and adaptive immunity [ 33 , 34 ]. However, oxidative and inflammatory processes that are associated with retinal degenerative diseases can manifest as an elevated concentration of the respective markers in AH. Indeed, alterations in malondialdehyde concentration and total antioxidant activity were found in AH of patients with glaucoma and exfoliation syndrome, as well as in animals with intraocular inflammation [ 35 , 36 , 37 , 38 ]. Furthermore, the increased levels of pro-inflammatory cytokines characterize AH of patients with AMD, diabetic retinopathy, macular edema, and glaucoma [ 39 , 40 , 41 , 42 ]. Meanwhile, alterations in oxylipin content of AH that are associated with LIRD and other retinal degenerative diseases remain mostly uninvestigated. Previously, we have developed a rabbit model of LIRD reproducing many aspects of AMD and other retinal degenerative diseases, such as apoptosis of photoreceptors and migration of RPE cells, as well as the breakdown of the blood-retinal barrier, leukocyte infiltration, edema, and other signs of intraocular inflammation [ 3 , 14 , 43 ]. These effects were accompanied by oxidative stress, which was efficiently prevented by premedication while using mitochondria-targeted antioxidant SkQ1 [ 3 ]. In the present study, we employed this model of LIRD to get insight into oxidative and inflammatory processes contributing to retinal degeneration diseases, such as AMD. To this end, we performed pathomorphological and electrophysiological characterization of degenerative processes in the light-exposed retina and described the histological signs of the accompanying inflammation. We next examined changes in the content of inflammatory and oxidative stress markers in AH of the illuminated animals at different stages of LIRD. Moreover, while using the quantitative metabolomic (Ultra Performance Liquid Chromatography—Tandem Mass Spectrometry, UPLC-MS/MS) technique, we identified, for the first time, alterations in the AH patterns of different lipid mediators, such as phospholipid derivatives, polyunsaturated fatty acids (PUFAs), and oxylipins, which are associated with development of LIRD. The obtained data provide a rationale for using a combination of antioxidant and non-steroidal anti-inflammatory (NSAID) drugs for the prevention and treatment of oxidative stress and inflammation that are associated with LIRD. Consistently, we demonstrated that premedication of the eyes with mitochondria-targeted antioxidant SkQ1 with their subsequent treatment while using topical NSAID Nepafenac results in suppression of lipidomic signs of oxidative stress and inflammation and the overall improvement of the state and functionality of the illuminated retina. Therefore, the latter two-component approach was suggested to be of high potential in complex treatment of AMD and other retinal degenerative diseases. 2. Results 2.1. Clinical, Electrophysiological and Morphological Characteristics of the Rabbit Model of LIRD In the first step, we monitored the clinical state of the rabbit eyes in the course of LIRD focusing on possible signs of the associated inflammation. To this end, the animals of the model group (see Section 4.3 .) were subjected to slit lamp and indirect funduscopic examinations performed prior to the light exposure, immediately after the illumination, as well as on the 1, 3, and 7 day of the subsequent period. We observed an optically clean vitreous body and a moderately vascular retina at all of the time points. The blood vessels extended medially and laterally to the optic disk, and the vessels of the choroid were wide and straight. No signs of vitreous body clouding, exudate, thinning of the vessels, swelling of the optic nerve, hemorrhage, or retinal detachment were detected both prior and after the illumination. Thus, the eyes of the animals that were exposed to bright light exhibited no macroscopic signs of retinal inflammation or edema. We next examined whether the bright light illumination induced general changes in the functional activity of the retina by electroretinographic (ERG) study conducted prior to the illumination and on the seventh day after the exposure. The retinograms were recorded under scotopic conditions by adapting animals to the dark and subsequent registration of ERG response to a flash ( Figure 1 ). It was found that irradiation leads to a noticeable decrease in electrophysiological activity of the retina with similar alterations in both a- and b-waves (a decrease in amplitude and a slight increase in latency), reflecting the decrease in total responses of both photoreceptors and non-photoreceptor (predominantly bipolar) neurons of the retina. We performed histological analysis of the posterior segment of the affected eyes to assess pathomorphological alterations underlying the revealed functional abnormalities of the illuminated retina. No differences were found between the state of the retina obtained immediately after the light exposure or on the next day and the retina of the intact animals ( Figure 2 A–C). However, three days after the illumination the multiple signs of the retinal damage were observed ( Figure 2 D). Generally, they included swelling and destruction of the outer segments of photoreceptors (Ph) and the cell death of photoreceptors and inner nuclear layer (INL) neurons (manifested as the formation of apoptotic bodies and their phagocytosis by macrophage-like cells), which results in a decrease in the thickness of these layers and the total thickness of the retina (up to subtotal or total retinal atrophy in some locations). There were also areas of retinal detachment with the formation of a space containing apoptotic bodies and photoreceptors fragments, some of which were phagocytized by activated RPE cells that migrated to these areas. Seven days after illumination, the acute phases of cell deaths were completed and the retina exhibited compensatory and regenerative processes ( Figure 2 E–H) manifested as an increase in retinal eosinophilia due to the activation and hypertrophy of Mueller glia. Importantly, the sites of damage (three day) and regeneration (seven day) were located focally over the retina, which is associated with its heterogeneous photosensitivity. Such character of the destruction might explain the absence of its macroscopic signs in the fundoscopic examination. Nevertheless, a general consequence of the irradiation can be defined as a decrease in the amount of cells over the entire retina, especially in the outer nuclear layer (ONL). Interestingly, the development of LIRD was associated with a histologically manifested inflammatory process. In particular, the areas of retinal atrophy and the RPE layer were in some places that were infiltrated by granulocytes and the choroid was characterized by increased cellularity and possessed enhanced fibroblast reproduction. In addition, the retina occasionally contained cysts and canals that were filled with edematous fluid. The inflammation seems to have a chronic character, as its signs maintained, even on the seventh day after the illumination. We concluded that our model of LIRD involves not only loss of photoreceptors and other neurons and, consequently, the suppression of the retinal activity, but also the development of local inflammation and, thereby, can be employed for investigation of inflammatory mechanisms that are associated with retinal degenerative diseases. 2.2. Biochemical Manifestations of LIRD-Associated Inflammation in the Aqueous Humor Intraocular inflammation is known to manifest in AH by increased concentration of proteins, oxidative stress markers, and inflammatory molecules (see Introduction). As such, we assessed the biochemical alterations in AH, which are associated with the development of LIRD in experimental animals. AH collection and analysis were performed prior to the light exposure and during the next seven days. All of the samples exhibited an acute elevation of the total protein concentration ( Figure 3 ). The protein concentration reached more than four-fold excess during the illumination and returned to the baseline control value within the next 24 h. This phenomenon was accompanied by elevation of concentration of TNF-α, the pro-inflammatory cytokine most commonly found in AH ( Figure 3 ). Yet, in contrast to the total protein, the concentration of TNF-α was maintained at a high level until the seventh day, which indicated the development of chronic inflammation in accordance with our histological observations (see Figure 2 ). Interestingly, all of these effects were accompanied by alterations in the redox state of AH. Thus, we detected an increase in the AH concentration of malondialdehyde, representing a product of lipid peroxidation. The highest level of this compound was detected on the first day after illumination, whereas, on the seventh day, its concentration normalized ( Figure 3 ). The opposite dynamics was expectedly peculiar to the total antioxidant activity of AH ( Figure 3 ). Finally, we observed a moderate decrease in AH concentration of common antioxidant enzymes, superoxide dismutase, and glutathione peroxidase, during the illumination. Within the next days, both of the enzymes demonstrated uptrend, although glutathione peroxidase exhibited a statistically significant decrease on the seventh day ( Figure 3 ). These data, taken together, indicate that LIRD is preceded and accompanied by oxidative stress and inflammatory reactions, the signs of which manifest in AH. 2.3. Lipidomic Signs of LIRD-Associated Inflammation in the Aqueous Humor The mechanisms of the revealed LIRD-associated oxidative stress and inflammation can be determined by analyzing the patterns of lipid mediators, such as PUFAs and their oxidized derivatives, oxylipins. Therefore, we performed quantitative mass-spectrometry studies of the lipids extracted from AH samples, which were obtained immediately before and immediately after illumination of the animals, as well as on the 1, 3 and 7 day post-exposure. UPLC-MS/MS analysis identified a total of 17 lipid compounds ( Figure 4 ), including three PUFAs (AA, docosahexaenoic acids (DHA), and eicosapentaenoic acid (EPA)), two phospholipid derivatives ((Z)-N-(2-Hydroxyethyl) octadec-9-enamide (oleoylethanolamine, OEA), 1-O-hexadecyl-sn-glyceryl-3-phosphorylcholine (lyso-Platelet-Activating Factor, lyso-PAF)), and twelve oxylipins. The latter compounds included four AA derivatives (prostaglandin E2 (PGE 2 ), prostaglandin D2 (PGD 2 ), prostaglandin F 2a (PGF 2α ), and leukotriene B4 (LTB 4 )), and eight linoleic acid (LA) derivatives (9-/13-hydroxyoctadecadienoic acids (9-HODE/13-HODE), 9-/13-oxo-octadecadienoic acids (9-KODE/13-KODE), 9,10-/12,13-epoxyoctadecamonoenoic acids (9,10-EpOME/12,13-EpOME), and 9,10-/12,13- dihydroxyoctadecamonoenoic acids (9,10-DiHOME/12,13-DiHOME)). In our LIRD model, we revealed a short-term increase in the AH content of AA and DH and a decline in levels of EPA during the illumination (indicated in Figure 4 as gray boxes). In addition, we detected a more prolonged increase in the concentration of Lyso-PAF. These short-term responses (except for EPA) mostly resolved within the next 1–3 days. Remarkably, there were obvious trends in the dynamics of oxylipins content during the development of LIRD. The most pronounced changes were found in prostaglandins PGE 2 , PGD 2 , and PGF 2α demonstrating a long-term increase, which, in the case of PGF 2α , did not resolve, even at the seventh day post-illumination. By contrast, almost all of the LA derivatives exhibited a short burst during the light exposure and their concentration tended to recover in one day. Notably, whereas prostaglandins are biosynthesized mostly via COX-dependent pathway, the detected LA derivatives can be generated not only by enzymatic (LOX-dependent and CYP-dependent), but also by non-enzymatic mechanisms that involve ROS (the respective indications are given in Figure 4 ). Thus, one can expect that LIRD-associated inflammation can be responsive to a treatment while using COX inhibitors (such as NSAIDs) and antioxidants. 2.4. Functional and Morphological State of the Retina in the Course of Combined Antioxidant/Anti-Inflammatory Treatment of LIRD-Associated Inflammation We next analyzed the functional and morphological state of the retina in four groups of experimental animals with the induced model of LIRD to confirm our conclusions regarding mechanisms of LIRD-associated inflammation and to find new routes for its prevention and treatment (See Section 4.3 .). The animals of the first group were subjected to the illumination without any subsequent treatment. In the second group, the animals were premedicated prior to the illumination with mitochondria-targeted antioxidant SkQ1, according to the method that was developed in our previous study [ 3 ]. The animals of the third group were treated for seven days after the illumination with Nepafenac, representing topical NSAID that is commonly used for the treatment of ocular inflammation [ 44 ]. Finally, the rabbits of the fourth group received combined therapy involving the administration of both the antioxidant and the NSAID. ERG studies revealed that premedication with SkQ1 efficiently preserved normal electrophysiological activity of the retina in light-exposed animals ( Figure 5 A). Indeed, the amplitudes of both a-wave and b-wave of the retinogram corresponded to that of the healthy retina ( Figure 5 B). The treatment of animals with Nepafenac on the background of premedication with SkQ1 did not give a noticeable additive effect in ERG (data not shown), apparently due to almost the complete protection of the retinal neurons by SkQ1. According to histological study, on the seventh day after irradiation, the retina of the animals that were premedicated with SkQ1 contains much less prominent areas of atrophy, activation of Müller glia and remodeling processes ( Figure 6 B) than non-premedicated retina ( Figure 6 A). However, the signs of pre-existed inflammation were still occasionally observed in these animals ( Figure 6 B, orange arrow). By contrast, no such signs were found in rabbits, which were additionally treated with Nepafenac ( Figure 6 D). Interestingly, the retina of the animals that solely received Nepafenac treatment was characterized by loci of the decreased thickness of the ONL, although inflammatory infiltration and edema were completely absent in this case ( Figure 6 C). Taken together, these data demonstrate that both SkQ1 and Nepafenac produce therapeutic effects in LIRD, and these effects are synergistic. 2.5. Biochemical and Lipidomic Alterations in the Aqueous Humor in the Course of Combined Antioxidant/Anti-Inflammatory Treatment of LIRD-Associated Inflammation Biochemical analysis of AH samples that were collected from the rabbits of same groups (see previous section) revealed that all of the variants of the therapy did not have any reliable acute (short-term) effects, such as increase in total protein concentration, but demonstrated a delayed benefit in respect to recovery of almost all of its parameters ( Figure 7 ). Particularly, in the presence of premedication/treatment, we observed the suppression of malondialdehyde (peak on one day) and the increase in total antioxidant activity (peak on seven day), as well as pronounced elevation of superoxide dismutase and glutathione peroxidase activities (peak on three day). An exception was TNF-α, which exhibited a slight increase during Nepafenac treatment, although it was statistically insignificant. Notably, in all cases, the most prominent effects were observed in the case of the combined treatment, which indicated synergistic mechanisms of action of SkQ1 and Nepafenac towards LIRD-associated inflammation. However, most of the information regarding these mechanisms was obtained through analysis of lipidomic alterations in AH of the animals from the abovementioned groups ( Figure 8 ). Nepafenac expectedly downregulated all of the COX-generated oxylipins (prostaglandins), starting from the very begin of the treatment (the first day after illumination). In the same time, premedication with SkQ1 produced comparable suppressive effects on these oxylipins, although the combined therapy was somewhat more effective. By contrast, AH concentration of LA-derived oxylipins was only affected by the antioxidant premedication and the suppressive effect of the combined therapy was seemingly solely provided by SkQ1. Interestingly, neither of the secreted PUFAs were affected by any kind of treatment. At the same time, Nepafenac potently downregulated lyso-PAF and this effect seems to be specific to this NSAID, as it cannot be substituted by SkQ1. Taken together, our data confirm that LIRD is preceded and accompanied by oxidative stress, as well as inflammation mainly governed by COX-dependent pathways and consistently sensitive to NSAID Nepafenac. Both mechanisms can be suppressed by SkQ1 exhibiting not only antioxidant, but also anti-inflammatory effects and, therefore, strongly protecting the structure and electrophysiological activity of the retina. Meanwhile, Nepafenac possesses specific anti-inflammatory effects and, therefore, complements SkQ1 protection, as evidenced by histological data. These findings provide a rationale for the inclusion of a combination of both drugs in the therapy of LIRD-associated inflammation. 3. Discussion Growing evidence indicates that inflammation contributes to the pathogenesis of a number of blind-causing retinal degenerative diseases, such as AMD or photic maculopathy [ 45 ]. The aim of the present study was to identify inflammatory mechanisms that are associated with retinal degeneration and, based on these data, suggest possible routes for its prevention and treatment. We used a rabbit model of LIRD that was previously developed in our laboratory to reach this aim [ 3 , 14 , 15 ]. Indeed, there are a number of important similarities in ocular morphology and biochemistry between human and rabbit eyes, which make rabbits attractive species for modeling ocular diseases [ 9 ]. The animal models of LIRD are generally acknowledged for AMD studies as they share many common features with the human disease (discussed in [ 3 ]). Consistently, we previously demonstrated that exposure of the eyes of experimental animals (rats and rabbits) to different doses of bright visible light leads to the development of retinal degenerative processes, including the apoptosis of photoreceptors and other retinal neurons, as well as vacuolization of RPE cells, their phagocytic activity, and migration into the neural retina, representing common hallmarks of AMD [ 3 , 14 , 15 , 43 ]. In the present study, we used a rabbit model of LIRD that was induced by intense short-term illumination (30,000 lx for 3 h) [ 3 , 15 ]. We complemented its histological characterization with electrophysiological (ERG) data in order to more accurately describe the pathological process. It was found that light irradiation of the rabbit eye indeed suppresses the functionality of the retina by affecting both a- and b-waves of ERG. These data reflect a decrease in total responses of both photoreceptors and non-photoreceptor (predominantly bipolar) neurons of the retina, which is in good agreement with our pathomorphological findings. Interestingly, in previous LIRD studies, we have observed that focal signs of inflammation including disturbance in the blood-retinal barrier and inflammatory infiltration accompany the development of the degenerative changes in the retina. Indeed, retinal edema was found to already emerge at the early stages of LIRD, gradually expanding in the course of the disease and becoming complemented by granulocytic infiltration [ 14 , 43 ]. All of these signs were occasionally found in the model used in the current work, indicating that intraocular inflammation is a sustainable complication of LIRD. Importantly, similar inflammatory processes were observed in AMD [ 45 ]. Thus, along with biochemical signs, such as the presence of inflammatory components in drusen, both early and atrophic forms of AMD can exhibit acute inflammation symptoms, including increased infiltration of inflammatory cells in the retina [ 18 , 46 ]. In turn, wet AMD is associated with the breakdown of the blood-retinal barrier, which promotes neovascularization and blood leakage from the abnormal vessels causing edema and detachment of the pigment epithelium and the retina [ 19 , 45 , 47 , 48 ]. In our LIRD model, we observed all of these signs, although they emerged focally, were of low severity and, therefore, did not manifest in the funduscopic examination. It should be added that, despite the absence of drusen in our model, it is characterized by extensive oxidative stress in the retina and RPE [ 3 ], which is known to play a crucial role in drusen formation and AMD (see Introduction section). Overall, the rabbit model of LIRD that is employed in this study reproduces different routs of AMD pathogenesis, including those that are related to oxidative stress and inflammation and, may, therefore, be used for trialing of the appropriate therapies. As it was stated above, analyzing the content of the appropriate markers in AH can be used to monitor the inflammatory reactions in the retina and the neighboring tissues. Although AH sampling is an invasive procedure, it is still accomplishable in humans in contrast to any of the tissue analyses, thereby supporting the diagnostic value of AH. The increased levels of pro-inflammatory cytokines in AH were previously found, not only in patients with pronounced intraocular inflammation (such as posterior uveitis), but also in individuals with AMD, diabetic retinopathy, macular edema, or glaucoma [ 39 , 40 , 41 , 42 ]. In the current study, we have demonstrated that the development of LIRD is accompanied by a chronic increase in the AH content of pro-inflammatory cytokine TNF-α. The latter was shown to accumulate in light-exposed rabbit retina [ 23 ] and, may, therefore, be secreted to AH. Furthermore, the levels of this cytokine were demonstrated to be elevated in AH of patients with dry or treated wet forms of AMD and diabetic retinopathy, but not glaucoma [ 41 , 42 , 49 ]. Thus, this cytokine can be considered as a specific AH marker of the inflammation, being associated with LIRD and similar retinal degenerative conditions. It should be added that anti TNF-α drugs were recently approved for the treatment of ocular inflammation [ 50 ]. Total protein concentration in AH is another well-known parameter characterizing intraocular inflammation. Inflammatory processes lead to the disruption of the blood-ocular barrier and enter of plasma proteins in the eye tissues, including AH. In the models of pronounced intraocular inflammation, such as endotoxin-induced uveitis, the total protein concentration in AH rapidly increases 15–30-fold and only resolves in seven days [ 36 , 37 ]. In our study, we observed only ~4-fold increase of this parameter and its recovery within 24 h, which confirms a moderate character of LIRD-associated inflammation. The crucial factor of LIRD is oxidative stress that is induced by multiple photochemical reactions occurring in the illuminated retina [ 16 ]. The rabbit model of LIRD, which was used in this study, was previously characterized in terms of the redox status of the retina. Oxidative stress was shown to manifest as a short-term increase in the retinal content of malondialdehyde and hydrogen peroxide [ 3 ]. In the current work, we expectedly monitored an increase in malondialdehyde in AH, which might reflect its accumulation in the illuminated degenerating retina. Consistently, the enhanced level of malondialdehyde in AH was demonstrated to accompany ocular inflammation [ 37 ]. Somewhat different trends were observed regarding total antioxidant activity, which moderately decreased in AH, in contrast to dramatic elevation in the illuminated retina [ 3 ]. Yet, this discrepancy might be explained by the fact that absolute antioxidant activity of AH is very high (it is highly enriched in ascorbate and other antioxidant molecules [ 51 ]) and, therefore, it is less affected by oxidative stress in neighboring tissues. Finally, we detected a decrease in AH activity of common antioxidant enzymes, superoxide dismutase, and glutathione peroxidase, which is characteristic for LIRD and endotoxin-induced ocular inflammation [ 23 , 37 ]. In the aggregate, all of these data confirm that oxidative stress is a hallmark of LIRD and the accompanying inflammatory responses occur on the background of oxidative processes, the signs of which can be detected in AH. Along with pro-inflammatory cytokine and biochemical markers of oxidative stress, while using a high-resolution quantitative lipidomic technique, we managed to reveal alterations in the AH patterns of lipid mediators, such as phospholipid derivatives, PUFAs, and oxylipins. The first principle effect that was identified in this study was a short-term increase in the concentration of AA and DHA, long-term decrease in levels of EPA, and long-term elevation of concentration of lyso-PAF and prostaglandins. These alterations are coherent with the upregulation of TNF-α and seem to reflect the mechanism of LIRD-associated inflammation. EPA generally possesses anti-inflammatory activity; it is present in AH at relatively low concentrations [ 52 ] and, therefore, expectedly decreases in response to LIRD-associated inflammation. DHA and its metabolites normally also exhibit anti-inflammatory activity, but this PUFA is present the retina in extremely high amounts and it plays specific roles in the structure and function of this tissue. In particular, DHA is released during oxidative stress to be converted into neuroprotective compounds, such as neuroprotectin D1 [ 53 ]. Thus, the increase in the AH concentration of DHA seems to represent the response of the retina to light-induced oxidative stress and degeneration, rather than inflammatory reaction. By contrast, AA has well-known pro-inflammatory properties and it has been implicated in triggering intraocular inflammation. Thus, it becomes released in response to the action of platelet-activating factor (PAF), which induces the generation of prostaglandins (both by upregulating AA and activating COX enzymes [ 54 ]), thereby promoting vascular permeability and macular edema [ 55 ]. Interestingly, intraocular inflammation can be induced not only by PAF, but also by its precursor/metabolite lyso-PAF taken in a similar dose [ 56 ]. Consistently, in our model, LIRD is associated with prolonged upregulation of lyso-PAF. Furthermore, PAF can be produced from lyso-PAF (by Lyso-PAF:acetyl-coenzyme A acetyltransferase) or from lysophosphatidyl choline (lyso-PC; biosynthesized by phospolipase A2), the concentration of which also increases in AH during ocular inflammation [ 57 ]. Given all of these data, it is not surprising that, in our model, LIRD is associated with prolonged growth in AH concentration of prostaglandins, among which PGF 2α remained elevated, even at the seventh day post-exposure. Indeed, LIRD is known to be accompanied by an increase in expression levels of COX-2 in the retina [ 23 , 24 ]. A similar growth of AH concentration of prostaglandins was observed in rabbit models of endotoxin-induced uveitis, BSA-induced uveitis, paracentesis, laser irradiation, etc. [ 58 , 59 , 60 , 61 ], which indicated that the above-described inflammatory mechanism is common for intraocular inflammation of different origins. According to our data, the signs of LIRD-associated inflammation can be effectively suppressed by the treatment of the eyes with ocular NSAID Nepafenac. This drug represents a precursor of Amfenac, which inhibits the activity of COX enzymes and thereby downregulates the synthesis of prostaglandins in the eye. Nepafenac is metabolized into amfenac in the ciliary body, choroid, and retina, and it is suggested for the treatment of inflammatory component of AMD and other retinal degenerative diseases [ 44 , 62 ]. The administration of Nepafenac in the rabbit eye was shown to reduce prostaglandin concentration in AH [ 63 ], which is in good agreement with our findings. Remarkably, in our LIRD model, Nepafenac also strongly reduced the AH level of lyso-PAF and significantly upregulated EPA. We can conclude that the effect of Nepafenac can be derived from regulating these mediators in addition to inhibiting the synthesis of prostaglandins, given the crucial role of lyso-PAF in promoting intraocular inflammation (see above), as well as anti-inflammatory activity of EPA. These novel findings add more insights to the general mechanism of the pharmaceutical activity of Nepafenac. The second principle effect that is identified in our lipidomic study is LIRD-associated short burst in AH content of linoleic acid derivatives HODE/KODE and EpOME/DiHOME, which resolves as fast as during 24 h after the illumination. These oxylipins possess both pro-inflammatory and anti-inflammatory activities and can be synthesized from LA via LOX- and CYP-dependent pathways, respectively [ 26 ]. Yet, in contrast to prostaglandins, they can also be produced by non-enzymatic mechanisms via the oxidation of PUFAs by free radicals [ 64 ]. While considering the fast dynamic changes in oxidative stress markers in the light-illuminated retina [ 3 ] and AH (this study), we suppose that the detected increase in LA derivatives mainly reflects LIRD-associated oxidative stress. Indeed, the retina is characterized by the highest content of PUFAs in addition to the highest metabolic rate and oxygen consumption among the human tissues and, therefore, it is extremely vulnerable to lipid peroxidation yielding corresponding oxylipins [ 16 , 28 ]. Furthermore, the accumulation of total LA-derivative HODEs in the retina was previously shown to accompany LIRD [ 29 ], which can underlie their secretion in AH. Notably, all of the effects of LIRD on AH concentration of LA-derived oxylipins are similarly inhibited by premedication of the rabbit eyes with mitochondria-targeted antioxidant SkQ1, whereas Nepafenac treatment was expectedly unfunctional in this respect. Indeed, SkQ1 was recently demonstrated to efficiently suppress LIRD by preventing light-induced oxidative stress, including lipid peroxidation [ 3 ]. It should be added that the inhibition of EpOME/DiHOME synthesis/release by SkQ1 is an important additional activity of the latter with respect to general protection of mitochondria, since these oxylipins are known to cause mitochondrial dysfunction [ 26 ]. Interestingly, along with suppressing LA-derived oxylipins, premedication with SkQ1 potently inhibits the growth of prostaglandins and produces an ant-inflammatory effect by upregulating EPA. There are data indicating that inflammation, being associated with retinal degeneration diseases, might be promoted by oxidative stress [ 65 ]. Thus, LIRD and associated inflammatory reactions can be suppressed by different antioxidants, such as resveratrol, celastrol, edaravone, etc. [ 65 , 66 , 67 ]. Yet, the mechanisms that underlie these relationships are yet to be fully understood. It should be emphasized that, in contrast to Nepafenac, SkQ1 does not restore normal AH level of lyso-PAF, which plays a central role in triggering LIRD-associated inflammation. In addition, it displays no effect on the antioxidant enzymes in AH. In our model of LIRD, the most prominent antioxidant and anti-inflammatory benefits were achieved by simultaneously administrating both SkQ1 and Nepafenac. Thus, the prominent neuroprotective activity of SkQ1 was supported by specific anti-inflammatory effects of Nepafenac. These findings the provide rationale for using such combined therapy with respect to LIRD, as well as AMD and other retinal degenerative diseases. 4. Materials and Methods 4.1. Materials The Institute of Mitoengineering of Moscow State University (Moscow, Russia) provided SkQ1 (10-(60-plastoquinonyl)-decyltriphenylphosphonium). Nepafenac (Nevanac), Alcaine and Betadine Ophthalmic were from Alcone (New York, NY, USA). Tiletamine and zolazepam were from Virbac (Carros, France). Xylazine hydrochloride was from Nita-Farm (Saratov Oblast, Russia). Phosphate buffer saline (PBS) was from Thermo Fisher Scientific (Waltham, MA, USA). Trolox (6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid) was from Sigma–Aldrich (St. Louis, MO, USA). TNF-α assay kit was from Cloud-Clone Corp. (Katy, TX, USA). Reagents for histological examination were from Biovitrum (Moscow, Russia). Malondialdehyde and bicinchoninic acid assay kits were from Sigma-Aldrich (USA). Glutathione peroxidase and superoxide dismutase assay kits were from Randox (Crumlin, UK). Oasis® PRIME HLB cartridge (60 mg, 3cc, cat.no. 186008056) were obtained from Waters (Eschborn, Germany). Other reagents and supplies were from Sigma–Aldrich, Amresco (St. Louis, MO, USA), and Serva (Heidelberg, Germany). All of the buffers were prepared while using ultrapure deionized water. 4.2. Animals and Ethics Statement The study involved 83 pigmented male rabbits six months old (2.3 to 3 kg) that were purchased from a certified farm (Krolinfo, Moscow, Russia). The animals were housed in individual cages at a 12 h light-dark cycle at a temperature of 22–25 °C and humidity of 55–60% with free access to maintenance rabbit food and water. The health status of the animals was monitored daily and no adverse events were observed. All of the experiments were performed under general anesthesia induced with intramuscular injection of 1:2 mixture of 50 mg/mL tiletamine/zolazepam and 20 mg/mL xylazine hydrochloride. Prior to AH collection, the animals were additionally instilled with topical anesthetic Alcaine. For the histological analysis of the posterior segment of the eye, the animals were humanely euthanized by an overdose of the anesthetic. The enucleating of the eyeballs was performed postmortem. After the other experiments, the animals were rehabilitated for three days and returned to the farm. The treatment of the animals was performed according to the 8th edition “Guide for the Care and Use of Laboratory Animals” of the National Research Council and “Statement for the Use of Animals in Ophthalmic and Visual Research” of The Association for Research in Vision and Ophthalmology (ARVO). The Belozersky Institute of Physico-chemical Biology Animal Care and Use Committee approved the protocol (Protocol number 1/2016). 4.3. Experimental Model The experiments were performed while using a single-blind method. Before the experiments, the rabbits were housed as described above for one week for acclimatization. The animals were divided into six groups, including absolute control (seven animals), model (12 animals), and four experimental groups (groups 1–4, 16 animals in each group). The absolute control group contained intact animals, kept during the experiment under the normal conditions described above. The animals of the model and experimental groups were exposed to bright visible light (30,000 lx, 3 h, 0.15 W/cm 2 ) under general anesthesia, exactly as described in our previous study [ 3 ]. Eight hours before the illumination the all animals (including the absolute control group) were kept on a diet with only free access to water. Immediately after the illumination, or after 1, 3, or 7 days post exposure (during these time periods the animals were housed under normal conditions described above), the animals of the model group were subjected to clinical and ERG examination (ERG was performed prior to illumination and on the seventh day), and then sacrificed for histological analysis. The animals of the experimental groups were left without treatment (group 1), or premedicated with SkQ1 prior to illumination (group 2), or treated with Nepafenac for seven days after the illumination (group 3) or premedicated with SkQ1 and treated with Nepafenac for seven days after the illumination (group 4). Premedication with SkQ1 included six subsequent conjunctival instillations (one instillation per 10 min.) of 50 μL of 7.5 μM SkQ1 in each eye, as described in [ 3 ]. Treatment with Nepafenac included conjunctival instillations of 50 μL of Nevanac in each eye three times a day. Immediately after the illumination or 1, 3, or 7 days post exposure the animals of the experimental groups were subjected to clinical examination and ERG, as well as a procedure of AH collection, as described below. Three animals from each experimental group were euthanized and posterior segments of their eyes were subjected to histological analysis. 4.4. Clinical and Electrophysiological Examination Clinical examination was performed while using a slit lamp (Heine, Herrsching am Ammersee, Germany) and a fundus camera (Kowa Genesis-D, Tokyo, Japan). The possible changes in the cornea, lens, vitreous, retina, and optic nerve were evaluated. The standard scotopic ERG was recorded using visual electrophysiology system RETIport ERG (An-vision, Germany). Prior to the examination, the animals were dark-adapted for 1 h. The recordings were performed under conditions of general anesthesia (see Section 4.2 .), topical anesthesia (Alcaine), and mydriasis (1% tropicamide). The active gold wire Koijman electrode was placed (via a contact lens) to the central cornea, whereas the needle ground and negative electrodes were subcutaneously positioned in the tissue 0.5 cm from the lateral angle of the eye and in the forehead tissue, respectively. Scotopic recordings were made while using white LED flashes (7000 K) at light intensity of 3 cd·s/m 2 with frequency of 0.3 Hz. The interferences were removed, the data were processed while using the software provided with the ERG system and visualized using SigmaPlot 11 (Systat Software, San Jose, CA, USA). The ERG analysis was made on amplitude of the a-wave and b-wave. 4.5. Histology Freshly enucleated whole rabbit eyes were fixed in 4% buffered formaldehyde (pH 7.4) for histological analysis and pathomorphological assessment. After the fixation, the anterior segment and vitreous were removed, and the posterior eye chambers containing retina, retinal pigment epithelium, choroid, and sclera were isolated. The preparations of posterior eye chamber were subjected to routine histological processing, including immersing specimens in a series of ethyl alcohol solutions. Properly the oriented preparations were embedded in paraffin, and 4 µm-thick midsagittal sections were obtained from each paraffin block. The sections were mounted on slides, deparaffinized, rehydrated, stained with Carazzi’s hematoxylin and eosin Y, and examined while using LEICA DM 4000B (Leica, Wetzlar, Germany) microscope. The microphotographs were obtained while using Leica DFC400 digital camera (Leica, Wetzlar, Germany). Processing of the microphotographs was performed using the AxioVision 8.0 (Carl Zeiss, Oberkochen, Germany) and Adobe Photoshop CS6 Extended (Adobe Systems, San Jose, CA, USA) software. 4.6. Aqueous Humor Collection AH was collected under general anesthesia (see Section 2.2 .). Prior to the procedure, the eyes were instilled with topical anesthetic Alcaine and irrigated with antiseptic Betadine Ophthalmic. 100–150 µL of AH was collected while using 30G needle and insulin syringe and aliquoted in sterile plastic tubes. For UPLC-MS/MS analysis, 50 µL of AH were mixed with 1 µL of 0.05% butylated hydroxytoluene. All of the samples were stored at −70 °C until biochemical or lipidomic examination. 4.7. Total Protein Concentration Measurement Protein concentration in the AH samples was measured while using bicinchoninic acid assay. Colorimetric reaction was monitored with Synergy H4 Hybrid plate reader (Biotek, Winooski, VT, USA). The calibration curve was constructed using 0.025–2 mg/mL bovine serum albumin solutions in PBS. 4.8. Lipid Peroxidation Analysis Measuring malondialdehyde content in AH samples by standardized thiobarbituric acid assay, while using commercially available reagent kit, was utilized to assess the level of lipid peroxidation. Colorimetric reaction was monitored with Ultrospec 1000 spectrophotometer (Pharmacia, Uppsala, Sweden). 4.9. Total Antioxidant Activity Analysis The total antioxidant activity in AH was analyzed via hemoglobin/H 2 O 2 /luminol system, as described in our previous works [ 68 , 69 , 70 ]. Briefly, the AH samples were diluted 200-fold with PBS and added to the reaction mixture, containing 0.01 mm luminol and 0.5 mm hemoglobin. The reaction was then induced by the addition of H 2 O 2 to the final concentration of 6 μm. After brief vortexing, the samples were placed in Glomax-Multi Detection System luminometer (Promega, Madison, WI, USA) and chemiluminescence was monitored every one second for 10 min. The calibration was performed while using 1–8 μm standard solutions of Trolox and the results were presented in the Trolox equivalent. 4.10. Antioxidant Enzyme Activity Analysis Superoxide dismutase and glutathione peroxidase activity in AH samples was measured by standardized tests while using commercially available kits. The acquired data were normalized to the total amount of protein in AH. All of the reactions were spectrophotometrically monitored using Synergy H4 Hybrid Reader (Biotek, Winooski, VT, USA). 4.11. TNF-α Concentration Measurement The cytokine content in the samples of AH was assessed by ELISA, while using commercially available kit. Synergy H4 Hybrid Reader was utilized to measure the intensity of colorimetric reaction. 4.12. Lipid Extraction The AH specimens were diluted with ice-cold anhydrous methanol, mixed with 2 ng of deuterated internal standard solutions, and centrifuged (12,000× g , 3 min.), mixed with 6 mL of 0.1% acetic acid and loaded onto solid-phase lipid extraction (Oasis ® PRIME HLB cartridge (60 mg, 3cc)). The cartridge was washed with 2 mL of wash solution (15% methanol, 0.1% formic acid), and the lipids were sequentially eluted with 500 μL of anhydrous methanol and 500 μL of acetonitrile. The resulting samples were mixed, concentrated under gentle stream of nitrogen, and stored at −70 °C until UPLC-MS/MS analysis. 4.13. UPLC-MS/MS Analysis For the identification of lipid mediators, the respective lipid extracts were analyzed while using 8040 series UPLC-MS/MS mass spectrometer (Shimadzu, Kyoto, Japan) in multiple-reaction monitoring mode at a unit mass resolution for both the precursor and product ions, as described previously [ 71 ]. Comprehensive analysis of lipid metabolites was performed by using a composition of internal standards (tetranor-PGEM-d6 (cat.no. 314840), 6-keto PGF1α-d4 (cat.no. 315210), TXB2-d4 (cat.no. 319030), PGF2α-d4 (cat.no. 316010), PGE2-d4 (cat.no. 314010), PGD2-d4 (cat.no. 312010), Leukotriene (LT) C4-d5 (cat.no. 10006198), LTB4-d4 (cat.no. 320110), 5(S)-HETE-d8 (cat.no. 334230), 12(S)-HETE-d8 (cat.no. 334570), 15(S)-HETE-d8 (cat.no. 334720), PAF C16-d4 (cat.no. 10010229), Oleoyl Ethanolamide-d4 (cat.no. 9000552), PGA2-d4 (cat.no. 310210) (Cayman Chemical, Ann Arbor, MI, USA), and a commercial software method package for lipid mediators (Lipid Mediator Version 2 software package Shimadzu, Kyoto, Japan), according to the manufacturer’s instructions. 4.14. Statistical Analysis The data were analyzed by the mean standard deviation (SD) method, while using SigmaPlot 11 for calculation and visualization. The Mann–Whitney U test was applied for an estimation of statistical significance. 5. Conclusions In this study, we ascertained the mechanisms of intraocular inflammation associated with LIRD in the rabbit model. Histologically, LIRD manifested as apoptosis of photoreceptors and other retinal neurons, as well as the vacuolization of RPE cells, their phagocytic activity, and migration into the neural retina. Pathomorphological changes were accompanied by the suppressed functionality of the retina, as evidenced by a decrease in ERG responses of both photoreceptors and non-photoreceptor neurons of the retina. All of these alterations were preceded and accompanied by oxidative stress and inflammation, as evidenced by granulocyte infiltration and edema in this tissue as well as the upregulation of total protein, pro-inflammatory cytokine, and oxidative stress markers (increased lipid peroxidation and decreased antioxidant activity) in AH. Quantitative lipidomic studies of AH elucidated neuroprotective (increased DHA) and inflammatory responses, including an increase in pro-inflammatory mediators AA and lyso-PAF, decrease in anti-inflammatory mediator EPA, and pronounced oxidative and inflammatory changes in the content of lipid mediators oxylipins. These changes include long-term elevation prostaglandins, which are synthesized from AA via COX-dependent pathways, as well as short bursts of LA derivatives that can be produced by both enzymatic and non-enzymatic free radical-dependent mechanisms. Premedication of the eyes using mitochondria-targeted antioxidant SkQ1 inhibited the upregulation of all oxylipins, whereas the accumulation of prostaglandins and lyso-PAF was specifically suppressed by topical treatment with COX inhibitor Nepafenac. Importantly, the most prominent antioxidant and anti-inflammatory benefits and overall retinal protective effects were achieved by the simultaneous administration of both drugs, indicating their synergistic action. Taken together, these novel findings add more insights to the mechanisms of antioxidant and anti-inflammatory action of Nepafenac and SkQ1, and they provide a rationale for their combined use in complex therapy of light maculopathy, AMD, and other retinal degenerative diseases. Author Contributions Conceptualization, D.V.C., P.P.P., I.I.S, M.G.S. and E.Y.Z.; Formal analysis, D.V.C., V.E.B. and I.I.S.; Funding acquisition, E.Y.Z.; Investigation, D.V.C., V.E.B., V.V.T., S.V.G., N.V.A., O.S.G., E.A.A., S.V.K. and I.I.S; Methodology, D.V.C., V.V.C., N.K.T. and I.I.S.; Project administration, E.Y.Z.; Resources, N.K.T., A.A.Z.J.; Supervision, A.A.Z.J., P.P.P., E.Y.Z.; Validation, D.V.C., M.G.S., and E.Y.Z.; Visualization, D.V.C., V.E.B., N.V.A., and O.S.G.; Writing-Original draft, E.Y.Z.; Writing-Review and editing, D.V.C., P.P.P. and E.Y.Z. All authors have read and agreed to the published version of the manuscript. Funding This research was funded by the RUSSIAN SCIENCE FOUNDATION, grant number 16-15-00255. Acknowledgments The authors acknowledge the Preclinical Clinical Study Centre, “RUDN University Program 5-100”, for their service with UPLC-MS/MS analysis. Conflicts of Interest The authors declare no conflict of interest. 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Alterations in electrophysiological activity of the rabbit retina under conditions of light-induced retinal degeneration (LIRD). The animals were illuminated with intense visible light (30,000 lx) for 3 h. ( A ) Representative scotopic electroretinograms recorded before (normal) and 7 days after the illumination. Recordings were made using white flashes at light intensity of 3 cd·s/m 2 . ( B ) Amplitudes of a- and b-waves of scotopic electroretinograms recorded before (normal) and seven days after the illumination. * p < 0.05 as compared with the respective parameters of the intact retina. Figure 1. Alterations in electrophysiological activity of the rabbit retina under conditions of light-induced retinal degeneration (LIRD). The animals were illuminated with intense visible light (30,000 lx) for 3 h. ( A ) Representative scotopic electroretinograms recorded before (normal) and 7 days after the illumination. Recordings were made using white flashes at light intensity of 3 cd·s/m 2 . ( B ) Amplitudes of a- and b-waves of scotopic electroretinograms recorded before (normal) and seven days after the illumination. * p < 0.05 as compared with the respective parameters of the intact retina. Figure 2. Histopathological findings in rabbit retina after the illumination with intense visible light (30,000 lx, 3 h). ( A – C ): before ( A ), immediately after ( B ) and one day after ( C ) the illumination retina demonstrates intact morphology. ( D ): acute signs of the retinal damage three days after the illumination. The signs include the presence of pycnotic nuclei and apoptotic bodies of photoreceptors (red arrows), retinal detachment from retinal pigment epithelium (RPE) (asterisks), activation of RPE cells (yellow arrows) and phagocytosis of apoptotic bodies by RPE cells (white arrows). ( E – H ): delayed signs of the retinal damage seven days after illumination. The signs include thinning of outer nuclear layer (ONL) and inner nuclear layer (INL) ( E ) and gliosis ( E , green arrow), total loss of photoreceptors ( F , black arrowhead), glial scar formation, and newly formed canals filled with edematous fluid ( F , red arrowhead), Muller glia activation and hypertrophy and eosinophilic areas ( G , green arrows), areas of ONL thinning ( H , black arrows) and inflammatory cells between photoreceptor layer and RPE ( H , orange arrows). Representative cross-sections of ocular fundus staining with hematoxylin and eosin; magnification 200×. Scale bar 20 μm. Retinal detachment at B and E is of artificial origin. Abbreviations: BV, blood vessel; GCL, ganglion cell layer; INL, inner nuclear retinal layer; MR, medullary ray; ONL, outer nuclear retinal layer; Ph, photoreceptor layer; RPE, retinal pigment epithelium; Sc, sclera. Figure 2. Histopathological findings in rabbit retina after the illumination with intense visible light (30,000 lx, 3 h). ( A – C ): before ( A ), immediately after ( B ) and one day after ( C ) the illumination retina demonstrates intact morphology. ( D ): acute signs of the retinal damage three days after the illumination. The signs include the presence of pycnotic nuclei and apoptotic bodies of photoreceptors (red arrows), retinal detachment from retinal pigment epithelium (RPE) (asterisks), activation of RPE cells (yellow arrows) and phagocytosis of apoptotic bodies by RPE cells (white arrows). ( E – H ): delayed signs of the retinal damage seven days after illumination. The signs include thinning of outer nuclear layer (ONL) and inner nuclear layer (INL) ( E ) and gliosis ( E , green arrow), total loss of photoreceptors ( F , black arrowhead), glial scar formation, and newly formed canals filled with edematous fluid ( F , red arrowhead), Muller glia activation and hypertrophy and eosinophilic areas ( G , green arrows), areas of ONL thinning ( H , black arrows) and inflammatory cells between photoreceptor layer and RPE ( H , orange arrows). Representative cross-sections of ocular fundus staining with hematoxylin and eosin; magnification 200×. Scale bar 20 μm. Retinal detachment at B and E is of artificial origin. Abbreviations: BV, blood vessel; GCL, ganglion cell layer; INL, inner nuclear retinal layer; MR, medullary ray; ONL, outer nuclear retinal layer; Ph, photoreceptor layer; RPE, retinal pigment epithelium; Sc, sclera. Figure 3. Alterations in biochemical properties of rabbit aqueous humor (AH) under conditions of LIRD. The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as gray box). AH samples were collected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The samples were analyzed for total protein, tumor necrosis factor alpha (TNF-α), and malondialdehyde content as well as total antioxidant activity (in Trolox equivalent) and activity of glutathione peroxidase and superoxide dismutase using the respective assays. * p < 0.05 as compared to parameters of AH of the intact (control) animals. Figure 4. Alterations in patterns of lipid mediators in rabbit AH under conditions of LIRD. The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as gray box). AH samples were collected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The concentrations of the lipid mediators (phospholipid derivatives, PUFAs and oxylipins) in aqueous AH were measured using quantitative UPLC-MS/MS analysis. * p > 0.05 as compared to the parameters of AH of the intact (control) animals. The identified oxylipins are divided into subgroups according to their origin and biosynthetic pathways, involving cyclooxygenases (COX), lipoxygenases (LOX), cytochrome P450 monooxygenases (CYP), or reactive oxygen species (ROS) (non-enzymatic pathway). Figure 4. Alterations in patterns of lipid mediators in rabbit AH under conditions of LIRD. The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as gray box). AH samples were collected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The concentrations of the lipid mediators (phospholipid derivatives, PUFAs and oxylipins) in aqueous AH were measured using quantitative UPLC-MS/MS analysis. * p > 0.05 as compared to the parameters of AH of the intact (control) animals. The identified oxylipins are divided into subgroups according to their origin and biosynthetic pathways, involving cyclooxygenases (COX), lipoxygenases (LOX), cytochrome P450 monooxygenases (CYP), or reactive oxygen species (ROS) (non-enzymatic pathway). Figure 5. Electrophysiological activity of the rabbit retina under conditions of LIRD with (blue) or without (pink) premedication using SkQ1. The animals were illuminated with intense visible light (30,000 lx) for 3 h. ( A ) Representative scotopic electroretinograms recorded before (black) and 7 days after the illumination. Recordings were made using white flashes at light intensity of 3 cd·s/m 2 . ( B ) Amplitudes of a- and b-waves of scotopic electroretinograms recorded before (normal) and 7 days after the illumination. * p < 0.05 as compared with the respective parameters of the intact retina. Figure 5. Electrophysiological activity of the rabbit retina under conditions of LIRD with (blue) or without (pink) premedication using SkQ1. The animals were illuminated with intense visible light (30,000 lx) for 3 h. ( A ) Representative scotopic electroretinograms recorded before (black) and 7 days after the illumination. Recordings were made using white flashes at light intensity of 3 cd·s/m 2 . ( B ) Amplitudes of a- and b-waves of scotopic electroretinograms recorded before (normal) and 7 days after the illumination. * p < 0.05 as compared with the respective parameters of the intact retina. Figure 6. Histopathological findings in rabbit retina seven days after the illumination with intense visible light (30,000 lx, 3 h) without treatment ( A ), after premedication with SkQ1 ( B ), after treatment with Nepafenac ( C ), and after premedication/treatment using the combination of the both drugs ( D ). ( A ): The retina demonstrates severe signs of damage including thinning of ONL and INL and total loss of photoreceptors (black arrows), gliosis, glial scar formation and formation of canals filled with edematous fluid (orange arrows) as well as Muller glia activation and hypertrophy (eosinophilic areas, green arrows). ( B ): The retina exhibits much less prominent damage (thinning of ONL and INL–black arrow, glial activation–green arrow), but signs of pre-existent inflammation are present (debris in semi-canal, orange arrow). ( C ): The retina shows thinning of ONL (black arrow) without signs of inflammation. ( D ): No signs of the retinal damage and/or inflammation. Representative cross-sections of retina, staining with hematoxylin and eosin; magnification 200× (400× on inset). Scale bar 20 μm. Abbreviations: GCL, ganglion cell layer; INL, inner nuclear retinal layer; ONL, outer nuclear retinal layer; Ph, photoreceptor layer. Figure 6. Histopathological findings in rabbit retina seven days after the illumination with intense visible light (30,000 lx, 3 h) without treatment ( A ), after premedication with SkQ1 ( B ), after treatment with Nepafenac ( C ), and after premedication/treatment using the combination of the both drugs ( D ). ( A ): The retina demonstrates severe signs of damage including thinning of ONL and INL and total loss of photoreceptors (black arrows), gliosis, glial scar formation and formation of canals filled with edematous fluid (orange arrows) as well as Muller glia activation and hypertrophy (eosinophilic areas, green arrows). ( B ): The retina exhibits much less prominent damage (thinning of ONL and INL–black arrow, glial activation–green arrow), but signs of pre-existent inflammation are present (debris in semi-canal, orange arrow). ( C ): The retina shows thinning of ONL (black arrow) without signs of inflammation. ( D ): No signs of the retinal damage and/or inflammation. Representative cross-sections of retina, staining with hematoxylin and eosin; magnification 200× (400× on inset). Scale bar 20 μm. Abbreviations: GCL, ganglion cell layer; INL, inner nuclear retinal layer; ONL, outer nuclear retinal layer; Ph, photoreceptor layer. Figure 7. Alterations in biochemical properties of rabbit AH under conditions of LIRD without treatment (black), in the course of treatment with Nepafenac (red), after premedication with SkQ1 (blue), and in the course of the therapy using the combination of the both drugs (green). The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as a gray box). The AH samples were collected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The samples were analyzed for TNF-α and malondialdehyde content as well as total antioxidant activity (in Trolox equivalent) and activity of glutathione peroxidase and superoxide dismutase using the respective assays. * p > 0.05 as compared to the parameters of AH of the untreated illuminated animals. Figure 7. Alterations in biochemical properties of rabbit AH under conditions of LIRD without treatment (black), in the course of treatment with Nepafenac (red), after premedication with SkQ1 (blue), and in the course of the therapy using the combination of the both drugs (green). The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as a gray box). The AH samples were collected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The samples were analyzed for TNF-α and malondialdehyde content as well as total antioxidant activity (in Trolox equivalent) and activity of glutathione peroxidase and superoxide dismutase using the respective assays. * p > 0.05 as compared to the parameters of AH of the untreated illuminated animals. Figure 8. Alterations in patterns of lipid mediators in rabbit AH under conditions of LIRD without treatment (black), in the course of treatment with Nepafenac (red), after premedication with SkQ1 (blue), and in the course of the therapy using the combination of the both drugs (green). The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as gray box). The AH samples were colected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The concentrations of the lipid mediators (phospholipid derivatives, PUFAs and oxylipins) in AH were measured using quantitative UPLC-MS/MS analysis. * p > 0.05 as compared to the parameters of AH of the untreated illuminated animals. The identified oxylipins are divided into subgroups according to their origin and biosynthetic pathways, involving COX, LOX, CYP, or ROS (non-enzymatic pathway). Figure 8. Alterations in patterns of lipid mediators in rabbit AH under conditions of LIRD without treatment (black), in the course of treatment with Nepafenac (red), after premedication with SkQ1 (blue), and in the course of the therapy using the combination of the both drugs (green). The animals were illuminated with intense visible light (30,000 lx) for 3 h (the course of the illumination is shown as gray box). The AH samples were colected before (norm) and immediately after (3 h) the illumination as well as on 1, 3, and 7 day post-exposure. The concentrations of the lipid mediators (phospholipid derivatives, PUFAs and oxylipins) in AH were measured using quantitative UPLC-MS/MS analysis. * p > 0.05 as compared to the parameters of AH of the untreated illuminated animals. The identified oxylipins are divided into subgroups according to their origin and biosynthetic pathways, involving COX, LOX, CYP, or ROS (non-enzymatic pathway). © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/ ). AMA Style
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(PDF) Chronic contained abdominal aortic aneurysm rupture causing vertebral erosion PDF | Erosion of vertebral bodies by an abdominal aortic aneurysm is extremely rare. Chronic contained rupture can cause difficulties in diagnosis... | Find, read and cite all the research you need on ResearchGate Chronic contained abdominal aortic aneurysm rupture causing vertebral erosion Asian Cardiovascular & Thoracic Annals 27(1):021849231877323 DOI: 10.1177/0218492318773237 Authors: Doan Quoc Hung Hanoi Medical University Abstract and Figures Erosion of vertebral bodies by an abdominal aortic aneurysm is extremely rare. Chronic contained rupture can cause difficulties in diagnosis because there are many clinical presentations: back pain, sciatic pain, or an expansive abdominal mass. Computed tomography is the gold-standard diagnostic tool. We report the case of a 49-year-old man who suffered from back pain because of a chronic ruptured aortic aneurysm. Computed tomography showing chronic contained rupture of an abdominal aortic aneurysm with erosion into the L3 vertebral body. … The ruptured aneurysm of the abdominal aortic posterior wall with erosion into the L3 vertebral body. … Figures - uploaded by Tran-Thuy Nguyen Discover the world's research 25+ million members Case Study Chronic contained abdominal aortic aneurysm rupture causing vertebral erosion T ran-Thuy Nguyen 1 , Ngoc-Thanh Le 1 and Quoc-Hung Doan 2 Abstract Erosion of vertebral bodies by an abdominal aortic aneur ysm is extremely rare. Chronic contained rupture can cause difficulties in diagnosis because there are many clinical presentations: back pain, sciatic pain, or an expansive abdominal mass. Computed tomography is the gold-standard diagnostic tool. W e report the case of a 49-year -old man who suffered from back pain because of a chronic ruptured aortic aneurysm. Keywor ds Aortic aneurysm, abdominal, Aortic rupture, Blood vessel prosthesis implantation, Low back pain, Lumbar vertebrae, Spinal diseases Introduction Erosion of vertebral bodies resulting from chronic con- tained rupture of an abdominal aortic aneurysm (AAA) is extremely rare. 1 The preoperative diagnosis can be difficult because of the variety of clinical presentations such as back pain, sciatic pain, or a pulsatile abdominal mass. In this regard, computed tomography is the best way to diagnose and define the disease. Surgical treat- ment is the best way to prevent complications. Case report A 49-year-old man with hypertension and dyslipidemia presented with a 2-month history of low back pain. He h a db e e no p e r a t e do nf o rar i g h tu r e t e r a ls t o n e2 2y e a r s earlier and diagnosed with grade IV chronic kidney dis- ease 8 years earlier. On examination, he had a pulsatile abdominal mass of 4 cm around the umbilicus, and blood pressure of 150/90 mm Hg. Laboratory tests pre-dialysis showed red blood cells 2.8  10 6 / m L, urea 44 mmol  L  1 , and creatine 1825 mmol  L  1 . Post-dialysis results were red blood cells 3.32  10 6 / m L, urea 12 mmol  L  1 , and cre- atine 710 mmol  L  1 . Computed tomography revealed an AAA of 64  40 mm in diameter. The AAA had caused erosion of up to 30% of the anterior walls of the L3 and L4 vertebrae (Figure 1). At vascular surgery, a ruptured AAA (diameter 5 cm) was found to have caused erosion of the posterior wall of the L3 vertebral body. Replacing the infrarenal aorta with a size 16 Uni-Graft and use of an aortic clamp for 35 min were indicated. A biopsy of the involved vertebral body and retroperitoneal hematoma showed no infection or malignancy (Figure 2). At s pinal surgery, we found that the L2–L4 vertebrae wer e almost completely eroded. Four staples were place d in the L2–L4 vertebrae and 4 screws were fixed to the left anter ior bodies. A 17  45-mm titanium mesh cage was used to fill in the pelvic bone to reconstruct the L3 vertebra (Figure 3). Postoperatively, the patient remained stable and was rehabilitated for walking after 7 days. He was discharged after 15 days. Follow-up over 24 months showed that he was relieved of his low back pain an d able to walk independently again. Subsequently, hemodi- alysis was performed 3 times per week. Asian Cardiovascular & Thoracic Annals 2019, Vol. 27(1) 33–35 ß The Author(s) 2018 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/0218492318773237 journals.sagepub.com/home/aan 1 Department of Cardiovascular and Thoracic Surgery, Cardiovascular Center, E Hospital, Hanoi, Vietnam 2 Department of Cardiovascular and Thoracic Surgery, Viet Duc Hospital, Hanoi Medical University, Hanoi, Vietnam Corresponding authors: Quoc Hung Doan, Hanoi Medical University, No 1 T on That T ung, DongDa, Hanoi, Vietnam. Email: [email protected] T ran-Thuy Nguyen, Department of Cardiovascular and Thoracic Surgery, Cardiovascular Center , E Hospital, 8789 Tran Cung, Cau Giay , Hanoi, Vietnam. Email: [email protected] Figure 1. Computed tomography showing chronic contained rupture of an abdominal aortic aneurysm with erosion into the L3 vertebral body. Figure 2. The ruptured aneurysm of the abdominal aortic posterior wall with erosion into the L3 vertebral body. 34 Asian Cardiovascular & Thoracic Annals 27(1) Discussion Chronic contained AAA rupture is an extremely rare condition. Since the initial description of 7 cases in 1961 by Szilagyi and colleagues, 1 less than 100 similar cases have been documented worldwide. 1–3 Diagnosis of chronic contained AAA rupture is difficult even in hos- pitalized patients. Booth and Galland 4 reported that the clinical features of contained AAA rupture are vague with back pain in 64% of cases, abdominal pain in 20%, groin pain in 14%, femoral neuropathy in 8%, sepsis in 10%, and asymptomatic in 8%. Our patient did not initially come to our department; he was examined for low back pain in the orthopedic depart- ment first. Characteristic findings are the presence of an AAA, pain, a patient whose condition is stable and whose hematocrit is normal, computed tomography showing a retroperitoneal hematoma, and pathological confirmation of an organized hematoma. 3 Our patient had hypertension and anemia due to grade IV chronic kidney disease. Hypertension is a risk factor for chronic contained AAA rupture, but according to Booth and Galland, 4 only 22% of patients are hypertensive. Computed tomography may be associated with prob- lems in the differential diagnosis with vertebral lysis due to another mechanism such as trauma, cancer, inflam- matory disease, or syphilis. 5 Our patient manifested vertebral erosions secondary to a primary AAA. These erosions developed as the result of a passive pro- cess. We did not identify any clinical signs or labora- tory results suggesting Behc ¸ et’s disease or infection with Mycobacterium tuberculosi s. In addition, we did not observe any specific or nonspecific signs of malignancy or infection in biopsies. Chronic contained AAA rupture warrants semi- emergency surgery. Open surgery is currently the rec- ommended treatment. 5 The technical feasibility of endovascular treatment for ruptured AAA has now been demonstrated, and this seems to be an interesting therapeutic alternative. 6 In cases of severe vertebral destruction, osteosynthesis of the vertebral bodies may also be necessary. 7 Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) received no financial support for the research, authorship, and/or publication of this article. ORCID iD Tran-Thuy Nguyen http://orcid.org/0000-0001-7129-0525 References 1. Li Y, Li L, Zhang D, Wang X, Sun W and Wang H. A contained ruptured abdominal aortic aneurysm present- ing with vertebral erosion. Ann Vasc Surg 2017; 41: 279.e13–279.e17. 2. Szilagyi DE, Smith RF, Macksood AJ and Whitcomb JG. Expanding and ruptured abdominal aortic aneurysms. Problems of diagnosis and treatment. Arch Surg 1961; 83: 395–408. 3. Saiki M, Urata Y, Katoh I and Hamasaki T. Chronic contained rupture of an abdominal aortic aneurysm with vertebral erosion: report of a case. Ann Thorac Cardiovasc Surg 2006; 12: 300–302. 4. Booth MI and Galland RB. Chronic contained rupture of an abdominal aortic aneurysm: a case report and review of the literature. EJVES Etra 2002; 3: 33–35. Available at: https://ac.els-cdn.com/S1533316702901287/1-s2.0-S153331 6702901287-main.pdf?_tid ¼ 910773c3-c707-48da-9541-5d4 db17ba505&acdnat ¼ 1522760258_554146950ca394a474- b6a7217fad528e. Accessed April 03, 2018. 5. Nya F, Atmani N, Seghrouchni A, Aithoussa M and Boulahya A. Vertebral erosion after chronic rupture of an infrarenal abdominal aortic aneurysm: about one case. J Cardiovasc Dis Diagn 2017; 5: 2. Available at: https://www.omicsonline.org/open-access/vertebral-ero- sion-after-chronic-rupture-of-an-infrarenal-abdominalaor- tic-aneurysm-about-one-case-2329-9517-1000262.php? aid ¼ 86652. Accessed April 03, 2018. 6. Seelig MH, Berchtold C, Jakob P and Scho ¨ nleben K. Contained rupture of an infrarenal abdominal aortic aneurysm treated by endoluminal repair. Eur J Vasc Endovasc Surg 2000; 19: 202–204. 7. Aydogan M, Karatoprak O, Mirzanli C, Ozturk C, Tezer M and Hamzaoglu A. Severe erosion of lumbar vertebral body because of a chronic ruptured abdominal aortic aneurysm. Spine J 2008; 8: 394–396. Figure 3. Fixation of the L2 and L4 vertebral bodies with screws and placement of a titanium mesh cage in the L3 vertebral body. Nguyen et al. 35 ... A CCR-AAA is a well-known, extremely rare subtype of AAA that was first reported by Szilagyi et al. in 1961 [1-3]. It is characterized by low blood loss and stable hemodynamics, which are due to hemostasis by tissue peripheral to the retroperitoneum when the aortic aneurysm ruptures [4, 5] . ... ... The diagnostic criteria for CCR-AAA consist of the following: (1) known AAA; (2) previous pain symptoms; (3) stable condition and normal hematocrit; (4) a CT scan showing a retroperitoneal hematoma; and (5) pathological confirmation of an organized hematoma [1,2]. Although back pain is common, cases of CCR-AAA present with a wide variety of clinical findings, including cases which are asymptomatic [4] [5] [6]. The diagnosis of CCR-AAA thus poses a dilemma. ... ... A ruptured abdominal aortic aneurysm is typically treated with open repair, although endovascular aneurysm repair has also recently been reported to be effective [11]. On the other hand, CCR-AAA has been treated in all reports with vascular prosthesis implantation or bypass surgery [1,2,[4] [5] [6]. As in the present case, endovascular aneurysm repair is difficult to perform in cases with arterial occlusion. Open surgery for diagnosis and treatment is considered suitable for cases in which the possibility of a tumor or infection cannot be ruled out before surgery. ... Chronic contained rupture of abdominal aortic aneurism complicated with aortic occlusion: a case report Article Full-text available Dec 2019 Azuma Tabayashi Takeshi Kamada Akihiko Abiko Hajime Kin Background: Chronic contained rupture is a subtype of an abdominal aortic aneurysm rupture. Its diagnosis is sometimes difficult due to lack of typical symptoms. We would like to report the challenge of diagnosing chronic contained rupture of abdominal aortic aneurysm with a retroperitoneal tumor. Case presentation: A 60-year-old man reported perceived lower abdominal pain 7 months earlier that spontaneously remitted. A contrast-enhanced computed tomography (CT) indicated an abdominal aortic aneurysm and a mass lesion surrounding the abdominal aorta and iliac arteries. Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) showed an increased accumulation of FDG in the margin of the lesion, indicating a retroperitoneal tumor. A CT-guided biopsy revealed only retroperitoneal fibrous tissue with chronic inflammation. We were thus unable to reach a definitive diagnosis. At 1 month after the initial examination, intermittent claudication was newly observed. A follow-up contrast-enhanced CT scan revealed abdominal aortic occlusion. Mass resection and bypass surgery were performed for diagnosis and treatment. Intraoperative and pathological findings led to the diagnosis of chronic contained rupture of an abdominal aortic aneurysm. The patient was discharged 19 days after surgery. Conclusion: The mass peripheral to the abdominal aorta should be considered the possibility not only of tumor but also of chronic contained rupture of an abdominal aortic aneurysm. ... In the future, we expect to further enrich the variability of the training data by improving the physical models or collecting more patient data to incorporate the marginal situations. Specifically, we generate a large amount of data by varying three parameters in the computational G&R simulations, which may not be enough to capture all the different features in actual AAA evolution, e.g., intraluminal thrombus [50,52,53], other morphological parameters [54,55], and influence of surrounding tissues [56, 57] . Hence, more parameters and more complex models will be carefully selected in the future to provide better simulation-based training data. ... A Deep Learning Approach to Predict Abdominal Aortic Aneurysm Expansion Using Longitudinal Data Article Full-text available Jan 2020 Zhenxiang Jiang Huan Do Jongeun Choi Seungik Baek An abdominal aortic aneurysm (AAA) is a gradual enlargement of the aorta that can cause a life-threatening event when a rupture occurs. Aneurysmal geometry has been proved to be a critical factor in determining when to surgically treat AAAs, but, it is challenging to predict the patient-specific evolution of an AAA with biomechanical or statistical models. The recent success of deep learning in biomedical engineering shows promise for predictive medicine. However, a deep learning model requires a large dataset, which limits its application to the prediction of the patient-specific AAA expansion. In order to cope with the limited medical follow-up dataset of AAAs, a novel technique combining a physical computational model with a deep learning model is introduced to predict the evolution of AAAs. First, a vascular Growth and Remodeling (G&R) computational model, which is able to capture the variations of actual patient AAA geometries, is employed to generate a limited in silico dataset. Second, the Probabilistic Collocation Method (PCM) is employed to reproduce a large in silico dataset by approximating the G&R simulation outputs. A Deep Belief Network (DBN) is then trained to provide fast predictions of patient-specific AAA expansion, using both in silico data and patients' follow-up data. Follow-up Computer Tomography (CT) scan images from 20 patients are employed to demonstrate the effectiveness and the feasibility of the proposed model. The test results show that the DBN is able to predict the enlargements of AAAs with an average relative error of 3.1%, which outperforms the classical mixed-effect model by 65%. ... It is represented as the discontinuity of the calcified aortic wall, a clearly limited mass of soft tissue density vaguely restricted from other adjacent structures (spine, psoas muscle) [5,6]. There are no signs of contrast extravasation within the mass described, which clearly differentiates it from true AAA rupture [7,8, 9] . Diagnosis of chronic AAA rupture is very important and unnecessary due to erosion of vertebral bodies and to find out the causes of them. ... Vertebral erosion due to chronic rupture of aneurismatic abdominal aorta Article Full-text available Jan 2019 Nikola Colic Dusan Saponjski Milica Stojadinovic Dragan Mašulović Introduction. Extremely rarely, the evolution of abdominal aortic aneurysm (AAA) includes the phase when extravasations of the blood from a ruptured aneurysm is contained by the surrounding tissue, referred to as chronic (contained) rupture of the AAA. Our aim was to call attention to this life-threatening condition, which is always challenging for diagnosis. Case outline. A 58-year-old man reported to the Emergency Center for significant abdominal pain. Ultrasound examination showed an infrarenal aneurysm of the abdominal aorta. A computed tomography scan of the thorax, abdomen, and pelvis with iodine contrast in arterial phase was performed. A free gas collection was observed between the liver and the anterior abdominal wall that is traced to a ruptured inflamed diverticulum on the transversal colon. Immediately distal to the branching sites of the renal arteries, the abdominal aorta extended forward and aneurismatically expanded. Posterior left, along the psoas muscle, a rupture of the aortic wall was seen, with an organized hematoma that accompanied the muscle. Between the hematoma and the aortic aneurysm, erosions of the anterior and lateral part of the vertebral bodies L2 and L3 were discovered. The patient underwent endovascular AAA repair (EVAR) and recovered well. Conclusion. Multidetector computed tomography angiography is a reliable, non-invasive, and necessary examination for localization and evaluation of the size of the AAA form, its chronic rupture, and complications such as vertebral body erosion. Chronic abdominal aortic rupture mimicking femoral neuropathy Article Full-text available Jul 2022 Pietro Modugno Fadia Salman Veronica Picone Massimo Massetti Chronic-contained rupture of an aortic aneurysm is a rare subset of ruptured aneurysms. The presentation is unusual, and the diagnosis is frequently delayed. Here, we describe a case of contained rupture of abdominal aortic aneurysm that presented with signs and symptoms of femoral neuropathy. Clinical and radiological findings were initially misinterpreted. The correct diagnosis was formulated belatedly, causing a progressively increased risk of fatal events. Surgical aortic repair was performed and the postoperative course was uneventful. In conclusion, in the presence of a retroperitoneal mass, a diagnosis of chronic-contained rupture of an abdominal aortic aneurysm should be considered. View Show abstract A Rare Case of Contained Chronic Rupture of Abdominal Aortic Aneurysm Associated With Vertebral Erosion: Pre- and Post-operative Findings on Computed Tomography and a Narrative Review Article Jun 2022 Vasc Endovasc Surg Marco Parillo Federica Vaccarino Bruno Beomonte Zobel Carlo Cosimo Quattrocchi Contained chronic rupture of aortic aneurysm (CCR-AA) is a rare condition that can be associated with vertebral body erosion (VBE) and is often a diagnostic challenge; in fact, CCR-AAs are in general hemodynamically stable and the patients tend to present with a non-specific low-back pain syndrome secondary to vertebral involvement. Furthermore, the differential diagnosis of a retroperitoneal mass can be difficult on medical imaging. We discuss the case of a 79-years-old man, heavy smoker without history of cardiovascular diseases, admitted to the emergency department with signs of left lower limb ischemia. The patient was hemodynamically stable and the medical examination revealed a pulsatile abdominal mass. Doppler ultrasound showed the presence of aneurysmal dilatation of infra-renal abdominal aorta and chronic femoropopliteal occlusion on the left side. The subsequent computed tomography angiography (CTA) demonstrated a voluminous retroperitoneal mass continuous with the infra-renal aorta, which infiltrated the psoas muscles and caused vertebral bodies erosion of the anterior wall in L2, L3 and L4 suspected for CCR-AA or mycotic aortic aneurysm. Furthermore, the examination confirmed the occlusion of the peripheral arterial circulation of the left lower limb. The patient underwent a successful open replacement of the infra-renal abdominal aorta through aorto-aortic prosthetic graft insertion; the visualization during the surgical procedure of a posterior vessel wall opening in continuity with the eroded vertebral bodies associated with negative microbiological culture of the thrombotic material sample, led to the definitive diagnosis of CCR-AA. The post-operative CTA showed successful open vascular treatment. A bypass surgery of the left lower limb was then performed with positioning saphenous graft between femoral common artery and posterior tibial artery. The patient was finally discharged in good clinical conditions. Vertebral Body Erosion by a Chronic Contained Rupture of Thoracoabdominal Aortic Aneurysm: Systematic Review and Spine Surgical Recommendations Article Nov 2021 Alessandro Pesce Daniele Armocida Gianpaolo Petrella Angelo Pompucci Background Vertebral body erosion (VBE) is commonly caused by neoplastic, inflammatory or infectious diseases: it can be rarely associated with aortic wall disorders, such as contained rupture of aortic aneurysm (CCR-AA). CCR-AA is a rare event consisting of less than 5% of all reported cases. This condition is easily undiagnosed, differential diagnosis may be challenging, and there is no consensus or recommendation that dictates guidance on management of spinal surgical treatment. Material And Methods We performed a systematic review of literature of all cases of VBE secondary to CCR-AA to identify clinical, radiological, and surgical outcome characteristics with the aim of providing a basis for future research studies. Results The search returned a total of 80 patients. All reported cases have a history of hypertension. In almost all cases the AA size reported was very high (mean diameter of 7.056 cm). The treatment of this condition involves various reported treatment strategies: a totally conservative approach, treatment of the aortic aneurysm through a minimally invasive endovascular procedure, or through open surgery and combined approach. Despite the wide variability in therapeutic strategy, the rate of good outcomes was 80%, relatively high. Conclusions ‘‘Back pain’’ and pain along the vertebral column are such frequent complaints that unusual etiologies or serious and life threatening complications may be overlooked. In addition to the common traumatic and degenerative causes of back pain, AA must also be considered. A combined approach between vascular and spine surgery could be achieved without any increased risk. The Association of Spondylitis and Aortic Aneurysm Disease Article May 2021 ANN VASC SURG Nikolaos Patelis Petroula Nana Konstantinos Spanos George Kouvelos Objectives: The aim of this study is to assess any relation between spondylitis and aortic aneurysmal disease by reviewing the current literature. Methods: A systematic search was undertaken using MEDLINE, EMBASE and CENTRAL databases till May 2019, for articles reporting on patients suffering from spondylitis and aortic aneurysm. Results: The most involved aortic segment was infrarenal aorta (56.9%). The lumbar vertebrae were more frequently affected (79.7%). Commonest symptoms were back pain (79.1%), fever (33.7%) and lower limb pain (29.1%). 55.8% of cases were diagnosed using computed tomography. The pathology was attributed to infectious causes in 25.1% of cases. 53.4% of patients were treated only for the aneurysm, 27.9% for both pathologies, while two patients solely for the vertebral disease. Endovascular aneurysm repair was chosen in 12.8% of cases. The 30-day mortality was 8.1% (7/86); mostly from vascular complications. Conclusions: A synchronous spondylitis and aortic aneurysm may share common etiopathology, when an infectious or inflammatory cause is presented. The lumbar vertebrae are more frequently affected. Low quality data do not allow safe conclusion to suggest the best treatment option. Chronic Contained Rupture of an Abdominal Aortic Aneurysm: a Case Report and Review of the Literature Article Feb 2002 M I Booth R B Galland Contained rupture of an infrarenal abdominal aortic aneurysm treated by endoluminal repair Mar 2000 EUR J VASC ENDOVASC Matthias H. Seelig Christoph Berchtold
https://www.researchgate.net/publication/324911775_Chronic_contained_abdominal_aortic_aneurysm_rupture_causing_vertebral_erosion
Materials | Free Full-Text | A Model Procedure for Catalytic Conversion of Waste Cotton into Useful Chemicals Cotton is grown in about 90 countries and accounts for 24% of the fibers used in the global production of textiles. In 2018/2019, 25.8 Mt of cotton were produced around the world. Since this natural product consists mainly of cellulose, it can be used as a raw material in the so-called “sugar economy”. This paper discusses a model procedure for thermally assisted acidic hydrolysis of cotton into glucose and subsequent oxidation of the glucose into calcium gluconate over Pd-Au/SiO2 catalyst. In the first step, H2SO4 was used as a catalyst for hydrolysis. The cotton hydrolysates were neutralized using CaCO3 and applied as a substrate in the second step, where glucose was oxidized over Pd-Au/SiO2 prepared by ultrasound assisted co-impregnation. With the appropriate Au/Pd molar ratio, small crystallites of palladium and gold were created which were active and selective towards the formation of gluconate ions. This approach to the transformation of glucose represents as a viable alternative to biological processes using fungal and bacterial species, which are sensitive to the presence of inhibitors such as furfurals and levulinic acid in hydrolysates. A Model Procedure for Catalytic Conversion of Waste Cotton into Useful Chemicals Justyna Malinowska 1 , Andrei Stanishevsky 2 , Courtney J. Severino 2 , Riley Yager 2 , Malgorzata Cieslak 3 and Izabela A. Witonska 1,* 1 Institute of General and Ecological Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland 2 Department of Physics, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA 3 ŁUKASIEWICZ Research Network—Textile Institute, Department of Textile Chemical Technologies, 118 Gdanska Street, 90-520 Lodz, Poland * Author to whom correspondence should be addressed. Materials 2021 , 14 (8), 1981; https://doi.org/10.3390/ma14081981 Received: 7 March 2021 / Revised: 30 March 2021 / Accepted: 12 April 2021 / Published: 15 April 2021 (This article belongs to the Special Issue Green Synthesis and Transformation in Material Science ) Abstract Cotton is grown in about 90 countries and accounts for 24% of the fibers used in the global production of textiles. In 2018/2019, 25.8 Mt of cotton were produced around the world. Since this natural product consists mainly of cellulose, it can be used as a raw material in the so-called “sugar economy”. This paper discusses a model procedure for thermally assisted acidic hydrolysis of cotton into glucose and subsequent oxidation of the glucose into calcium gluconate over Pd-Au/SiO 2 catalyst. In the first step, H 2 SO 4 was used as a catalyst for hydrolysis. The cotton hydrolysates were neutralized using CaCO 3 and applied as a substrate in the second step, where glucose was oxidized over Pd-Au/SiO 2 prepared by ultrasound assisted co-impregnation. With the appropriate Au/Pd molar ratio, small crystallites of palladium and gold were created which were active and selective towards the formation of gluconate ions. This approach to the transformation of glucose represents as a viable alternative to biological processes using fungal and bacterial species, which are sensitive to the presence of inhibitors such as furfurals and levulinic acid in hydrolysates. Keywords: cotton waste utilization ; acidic hydrolysis ; Pd-Au/SiO 2 catalyst Graphical Abstract 1. Introduction The global demand for textiles is growing steadily, and looks set to continue rising [ 1 , 2 , 3 ]. In 2013, the global production of textile materials was around 85.5 Mt, and by 2025 it is estimated to increase to 130 Mt [ 4 ]. Textiles are used in a vast range of products, including clothing, bed linen, towels, and utility fabrics, which quickly become worn-out or fall out of fashion, ending up in landfills. As much as 63% of the textile fibers currently sold are derived from petrochemicals [ 5 ] and only 37% from natural fibers—mainly cotton (24%) [ 6 ], wool or linen. As well as direct and reactive dyes, pigments, components of printing pastes, polyacrylic coatings, and polyurethane coatings, many chemical modifiers are used to impart cotton textiles with special functions [ 7 , 8 ]. These chemicals include hydrophobic, oleophobic, and antistatic finishing agents, flame retardants, and UV radiation absorbers. Many such chemicals prevent the natural biodegradation of textiles, in part since they inhibit the growth of microorganisms (fungi, bacteria, etc.) [ 9 ]. Therefore, textiles constitute a significant group of wastes, which are difficult to biodegrade in the natural environment. Many low-quality cotton products are unsuitable for material recycling and reuse. A possible solution is to convert cotton textiles by chemical-biological methods into useful energy products, such as biogas or into simple sugars, such as glucose. Via chemical or biological transformations, these products can then be made into valuable chemicals such as gluconic acid [ 10 , 11 , 12 , 13 ] or into other products such as hydrogen, vanillin or monolayer-patched graphene [ 14 , 15 , 16 , 17 ]. The catalytic transformation of glucose into gluconic acid over heterogeneous catalysts is of great interest to the industry [ 18 , 19 , 20 , 21 , 22 , 23 ]. Despite considerable economic and environmental interest in the development of methods for processing waste textiles for use as fermentation media or chemical substrates, there has been little discussion of this topic in the literature [ 24 , 25 , 26 , 27 ]. Preliminary studies show that even fabrics based on natural fibers (cotton, wool) only but subjected to a chemical treatment are not easily biodegradable in the natural environment, due to the presence of fermentation inhibitors such as furfurals and levulinic acid [ 28 ]. Therefore, catalytic transformation seems a better solution than biological methods to the problem of textile waste. Figure 1 shows a process for treating cotton waste, including textiles with synthetic additives (polyester and polyamide). It is based on acid hydrolysis of cellulose and further biological or catalytic transformation of the glucose into useful chemical products. Only some of the products that can be obtained from glucose are indicated in the diagram. A very important product for ensuring a waste-free process is activated carbon, which can be made from the solid residues after hydrolysis of cotton waste. The activated carbon may be used in the process itself to purify the hydrolysate from fermentation inhibitors or sold as a commercial product. Research efforts at Lodz University of Technology to torrefy the solid residue of cotton fibers after hydrolysis have shown that activated carbon with a high specific surface area (>500 m 2 /g) can be produced, which is capable of adsorbing the non-sugar components of hydrolysates. Lactic bacteria and yeast were successfully multiplied on hydrolysates purified on a bed of activated carbon produced from cotton waste. This research is ongoing and will be the subject of forthcoming publications. Figure 1. Scheme of cotton waste management, including acid hydrolysis and further chemical and biological processes to convert glucose into useful chemical products. In this paper, a model procedure for thermally assisted acidic hydrolysis of cotton materials is presented and discussed. Hydrolysates obtained from raw cotton yarn were used as the substrate for the catalytic transformation of glucose into gluconic acid over Pd-Au/SiO 2 catalysts. Bimetallic palladium–gold systems were prepared at Lodz University of Technology and used initially for the hydrogenation of furfural [ 29 ]. When it was observed that the bimetallic systems effectively catalyzed hydrogen transfer reactions, they were used for the oxidation of glucose, which occurs according to the oxidative dehydrogenation mechanism. 2. Materials and Methods 2.1. Catalyst Preparation The PdCl 2 solution (POCH S.A., Gliwice, Poland, pure for analysis) acidified to about pH 5 (HCl aq , 35–38%, pure for analysis) (CHEMPUR, Piekary Slaskie, Poland) was used to prepare a 5% Pd/SiO 2 catalyst by wetness impregnation of SiO 2 (Sigma-Aldrich Chemie GmbH, Taufkirchen, Germany, 291 m 2 /g). The preparation was left in an ultrasonic bath with a frequency of 45 kHz for 24 h. The water was evaporated by heating to 60 °C under a vacuum. The catalyst was air dried at 110 °C for 6 h then reduced for 2 h at 300 °C under an H 2 atmosphere (Air Products, Warsaw, Poland, Premium Plus, 99.999%, 20 cm 3 ·min −1 ). A linear temperature increase of 20 °C·min −1 was set for all stages of thermal processing. The same procedure was applied to prepare a 5% Au/SiO 2 (wt%) monometallic catalyst from an AuCl 3 solution (POCH S.A., Gliwice, Poland, 0.21 wt% Au). Pd-Au/SiO 2 catalysts containing 5 wt% Pd and 0.2–10 wt% Au were prepared by co-impregnation of a SiO 2 carrier with solutions of AuCl 3 (POCH, pure, 0.21% Au) and PdCl 2 (POCH, anhydrous, pure for analysis), according to the same procedure. All systems were subjected to ICP-AES (IRIS AP, Thermo Jarrel Ash, Waltham, MA, USA), XRD (PANalytical, Malvern, UK), ToF-SIMS (ToF-SIMS IV, ION-TOF GmbH, Münster, Germany), SEM-EDS (SEM S-4700, Hitachi, Tokyo, Japan; EDS, Thermo-Noran Inc., Madison, WI, USA), and XPS (VersaProbe 5000, PHI, Chanhassen, MN, USA) analysis to determine their compositions and identify metal interactions which could affect their catalytic properties in the glucose oxidation process. 2.2. Catalyst Measurements A glucose solution (GLU, POCH S.A. Gliwice, Poland, pure for analysis; C 0 GLU = 1.00 mol·dm −3 ; V GLU = 0.25·dm 3 ) was oxidized in a 0.4 dm 3 thermostated reactor (Parr Company, Moline, IL, USA) equipped with an O 2 supply system (Air Products, Pure N 5.2 UP, 99.9992%), a stirrer, a pH electrode (Mettler-Toledo Sp. z o.o., Warsaw, Poland), and a burette containing NaOH (POCh Gliwice, Poland, pure p.a.; C NaOH 0.50 mol·dm −3 ). The reaction was performed at pH 9, 60 °C. In each reaction run 1 g of catalyst was used. While the mixture was being stirred at 1300 rpm, O 2 was bubbled through at 0.9 dm 3 ·min −1 . Samples of the reaction medium were taken periodically for analysis. The samples were filtered and analyzed using a LaChrom liquid chromatograph (Marck-Hitachi, Tokyo, Japan) coupled to a UV–Vis detector (Marck-Hitachi, Tokyo, Japan), with an analytical wavelength of 200 nm. The reaction products were separated on a 150 × 3.3 mm ID amino-propylo-silicone column. A water solution of acetonitrile (70% ACN, 30% phosphate buffer pH 5.5) was used as a mobile phase. A Gilson’s prepELS II detector (Gilson Company, Inc. Lewis Center, OH, USA) was used as an additional analyzer in the HPLC system (Marck-Hitachi, Tokyo, Japan). The temperature of the spray chamber was 15 °C. The temperature of the drift tube was 85 °C. With these parameters, the retention times of all the considered compounds were: t fructose = 0.988 min; t glucose = 1.425 min; t gluconic acid = 8.230 min; t 2-keto-gluconic acid = 13.743 min; t guluronic acid = 15.260 min; t glucaric acid = 17.250 min, and it was possible to identify and determine the amounts of these compounds. Catalytic results were expressed as the conversion degree (X, %) and selectivity (S, %), defined as: X (%) = (1 − (C GLU /C 0 GLU )) × 100% S (%) = (C PROD /(C 0 GLU − C GLU )) × 100% where C 0 GLU is the molar concentration of glucose at the beginning of the oxidation process, C GLU is the molar concentration of glucose over time, and C PROD is the molar concentration of the product (fructose, gluconic acid, 2-keto-gluconic acid, guluronic acid, glucaric acid) over time. 2.3. Synthesis of Glucose from Cotton Yarn A water solution of glucose was obtained by acidic hydrolysis (H 2 SO 4 , analytical grade, 95%, Stanlab, Lublin, Poland) of cotton yarn Z689 × 2 S 542 (linear density 58.73 ± 0.641 tex, fiber length 15–32 mm, specific strength 18.44 ± 1.089 cN/tex). Cotton yarn hydrolysis was performed in a pressure reactor (Parr Instrument Company Series Mini 4552) with a volume of 7.5 dm 3 at a temperature of 120–160 °C. The start of the hydrolysis process was considered to be the moment when the reaction mixture reached the desired temperature. In each run, 100 g of comminuted cotton yarn (length > 0.5 cm) and 2.0 dm 3 of a solution of H 2 SO 4 (concentration 0.5–10%) were used. After 1–4 h, the reaction mixture was cooled in the reactor to room temperature and made alkaline by adding CaCO 3 (analytical grade, POCh, Gliwice, Poland) to pH 7.5. The mixture was then filtered through a bed of activated carbon and the glucose concentration was measured by high performance liquid chromatography (HPLC) using a SYKAM HPLC system with a S1125 HPLC Pump System, S 5300 autosampler, S 4115 column thermostat, and S 3585 RI detector (Sykam GmbH, Eresing, Germany). The sugars were separated on a SETREX IEX-H + column (300 × 8.0 mm ID) at 80 °C, using 0.008 mol·dm −3 H 2 SO 4 + 2%(v/v%) ACN (flow 0.8 cm 3 min −1 ) as a mobile phase. The quantitative analysis of glucose was performed based on the calibration curve for the range of glucose concentrations at 0–10 g dm −3 (the curve in the analyzed range was linear y = 0.19733 x, R 2 = 0.9998803). 2.4. Analytical Techniques Used for Measurements of Bimetallic Pd-Au/SiO 2 Catalysts A PANalytical X’Pert Pro MPD diffractometer (PANalytical, Malvern, UK) equipped with a PANalytical X’Celerator detector (PANalytical) was used to acquire X-ray diffraction patterns. The operating parameters for the Cu X-ray tube source were 40 kV voltage and 30 mA current. The XRD patterns were recorded from 20 to 90° 2θ with a 0.0167° step value and a 20 s dwell time. The crystalline phase analysis was performed using the ICDD PDF−2 (version 2004) database. The temperature programmed reduction (TPR) was performed using a flow apparatus [ 30 ]. Prior to the analysis, 0.1 g samples of the oxidized catalyst were flushed with argon at room temperature for 0.5 h. The TPR measurements were then performed at 25–500 °C with a linear temperature increase of 20 °C·min −1 under 5 vol% of H 2 in Ar at a flow rate of 30 cm 3 ·min −1 . The secondary ion mass spectra of the bimetallic catalyst samples (formed into tablets) were recorded using a secondary ion mass spectrometer (ToF-SIMS IV, ION-TOF GmbH, Münster, Germany) coupled to a ToF-SIMS IV time of flight detector (ToF-SIMS IV, ION-TOF GmbH, Münster, Germany, liquid metal 69 Ga + ion gun). An area on the sample surface 100 × 100 µm 2 in size was irradiated with 25 keV pulses of 69 Ga + ions at a 10 kHz repetition rate. The average ion current was 2.5 pA. As a result of the short analysis time (50 s), the ion dose was below the static limit of 1 × 10 13 ions/cm 2 . High resolution images were recorded using either the extreme crossover mode or the burst alignment mode. The ToF-SIMS spectra of the catalyst samples were recorded with a primary ion pulse width of 650 ns, a high mass resolution (m/Δm), and 29 mass units (m.s.) normally greater than 8000. A scanning electron microscope (SEM S-4700, Hitachi, Tokyo, Japan) equipped with an energy dispersive spectrometer (EDS, Thermo-Noran Inc., Madison, WI, USA) was used for the SEM analysis of the catalysts. Samples were embedded in conductive carbon pads and the excess loose powder was removed. To reduce electric charging, the samples were sputter coated with carbon (Cressington 208 HR system). Images were acquired in a back-scattered electron (BSE) mode. An accelerating voltage of 25 kV was used. For the purposes of comparison, the same samples were analyzed using an FEI Quanta 650 SEM (FEI Company, Hillsboro, OR, USA) equipped with a Bruker Energy Dispersive Spectroscopy (EDS) system (Bruker Corporation, Billerica, MA, USA). A 15 kV accelerating voltage, 3.5 µA electron beam current, and 10 mm working distance were used. The compositions of each sample were measured at least three times at different locations approximately 0.25 mm 2 in size. Samples were prepared by pressing the catalytic powders into high-purity carbon filled conductive tabs (PELCO Tabs™). An X-ray photoelectron spectroscope (XPS, PHI VersaProbe 5000, PHI, Chanhassen, MN, USA) was used to analyze the chemical bonding on the surface of the Pd-Au/SiO 2 catalysts. A focused monochromatic Al K-α source (E = 1486.6 eV; 100 µm spot diameter) was used to record survey and high-resolution spectra. Induced electric charge compensation was measured using a cold cathode electron flood gun and a low-energy Ar + ion-beam source. To avoid ion-induced surface damage, ion sputtering was not used. The recorded XPS spectra were fitted using a Multipak software package. The spectra were compared both to the NIST database (NIST Standard Reference Database 20, version 3.5) and to previously published data [ 29 ]. 2.5. Studies of Catalyst Stability in the Reaction Mixture Gold and palladium losses from the catalysts in the reaction mixture were determined by analyzing the filtered solution by inductively coupled plasma-atomic emission spectroscopy (ICP-AES), using an IRIS AP optical emission spectrometer (IRIS AP, Thermo Jarrel Ash, Waltham, MA, USA) with horizontal observation of the plasma. A MLS–1200 Mega Microwave Digestion System (Mile-stone) was used for complete digestion of the samples prior to the ICP-AES analysis. 3. Results In the previous research, we examined the catalytic properties of monometallic Pd/SiO 2 catalysts (0.5–10% by weight of Pd). It was observed that the amount of gluconic acid produced in the reaction increased with the percentage content of palladium. The highest selectivity was shown by the samples containing 5–10 wt% Pd/SiO 2 . These catalysts had practically the same selectivity. Therefore, adding more than 5 wt% of palladium into catalytic systems appears to be of no advantage from either an economic or practical point of view. Commercial catalysts recommended by manufacturers for use in liquid phase oxidation processes (e.g., Degussa catalyst) also contain about 5 wt% active metal, which means that the catalytic properties of the catalysts obtained in this study are comparable with commercial catalysts. Figure 2 shows the dependence of conversion and selectivity towards gluconic ions on the time of glucose oxidation over palladium-gold (Pd-Au) catalysts on silica. A 1 mol·dm −3 solution of pure commercial glucose in water was used as a substrate. Monometallic catalysts (5% Pd/SiO 2 and 5% Au/SiO 2 ) showed rather poor activity. In general, the addition of gold to the 5% Pd/SiO 2 systems caused an increase in the conversion degree of glucose. The addition of only a small amount of gold to the palladium catalysts (0.2–1 wt%) had a significant effect on the activity of the catalyst. However, in the case of 5% Pd-2% Au/SiO 2 and 5% Pd-5% Au/SiO 2 compared to monometallic catalysts, the increase in activity was lower than that in the bimetallic systems with lower amounts of gold. Therefore, amounts of gold higher than 1 wt% are counterproductive in Pd-Au/SiO 2 catalysts. Figure 2. ( A ) Conversion degree of glucose X [%]; ( B ) selectivity to gluconate ions S GLC [%] of different catalysts: 5% Pd/SiO 2 ( ); 5% Au/SiO 2 ( ); 5% Pd-0.2% Au/SiO 2 ( ); 5% Pd-0.5% Au/SiO 2 ( ); 5% Pd-1% Au/SiO 2 ( ); 5% Pd-2% Au/SiO 2 ( ); 5% Pd-5% Au/SiO 2 ( ), and 1% Pt-4% Pd-5% Bi/C (Degussa) (×) as a function of time. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm −3 , pH = 9, V O 2 = 1 dm 3 ·min −1 . All the studied bimetallic catalysts were characterized by high selectivity towards gluconic ions. In all cases, the selectivity of the Pd-Au/SiO 2 systems was comparable or even higher than in the case of the commercial Degussa catalyst (1% Pt-4% Pd-5% Bi/C). To understand the role of the Pd-Au/SiO 2 systems in the oxidation of glucose into gluconic acid in aqueous phase, the catalysts were analyzed using scanning electron microscopy (SEM), time-of-flight secondary ion mass spectroscopy (ToF-SIMS), X-ray diffraction (XRD), energy-dispersive x-ray spectroscopy (SEM-EDS), x-ray photoelectron spectroscopy (XPS), and temperature programmed reduction (TPR). Detailed results of these physicochemical tests are given in [ 29 ]. The XRD patterns show the maxima assigned to the metallic Pd phase ( Figure 3 ). The introduction of gold into the monometallic system was associated with the appearance of additional maxima on the diffraction patterns. The positions of the maxima shifted towards smaller values of the angle 2θ. The positions of the maxima in the diffractogram of the 5% Pd-5% Au/SiO 2 catalyst are close to the maxima corresponding to the gold phase. These results indicate the possible formation of solid solutions. In the case of the Pd-Au/SiO 2 systems activated in a hydrogen atmosphere at 300 °C, confirmation of the formation of solid solutions is given by the linear relationship between the interplanar distances as a function of the alloy composition, according to Vegard’s rule. No additional diffraction maxima were found in the diffraction patterns of the bimetallic systems, but only the maxima for the metallic Pd and Au phases. This indicates a lack of strong interactions between these metals, which would be manifested by the formation of intermetallic compounds. The results of the XRD tests were confirmed by XPS and TRR tests [ 29 ]. Figure 3. X-ray diffraction patterns for Pd-Au/SiO 2 catalysts: (1) 5% Pd/SiO 2 ; (2) 5% Pd-0.2% Au/SiO 2 ; (3) 5% Pd-0.5% Au/SiO 2 ; (4) 5% Pd-1% Au/SiO 2 ; (5) 5% Pd-2% Au/SiO 2 ; (6) 5% Pd-5% Au/SiO 2 ; (7) 5% Au/SiO 2 and the linear relationship of interplanar distances in the composition function of these systems (Vegard’s rule). The bimetallic catalysts were activated in a hydrogen atmosphere for 2 h at 300 °C. Adapted from ref. [ 29 ]. The addition of a larger amount of gold (>2 wt%) led to an increase in the intensity of the sharper diffraction peaks attributed to gold metal, which is evidence of the existence of larger Au crystallites on the surface of the bimetallic catalysts. Using the Scherrer equation, the average sizes of the palladium and gold crystallites were estimated. The results shown in Table 1 reveal that the palladium dispersion was greater in the case of bimetallic systems than for the monometallic 5% Pd/SiO 2 catalyst. Better Pd dispersion in the bimetallic systems may explain their higher activity and selectivity for gluconic acid. Moreover, the smallest Au crystallites formed on the 5% Pd-1% Au/SiO 2 catalyst. It is well known that the catalytic properties of gold strongly depend on the size of the gold particles [ 31 ]. Data in the literature show that monometallic gold carrier systems are catalytically active in the process of glucose oxidation when the Au particle size is less than 10 nm [ 32 ]. In the case of the 5% Pd-1% Au/SiO 2 catalyst, the estimated Au particle size was 8 nm. This catalyst also showed good catalytic properties for the oxidation of glucose to gluconic acid. Therefore, it cannot be ruled out that gold contributed to the increase in catalytic activity. Table 1. Size of palladium and gold crystallites calculated based on XRD measurements in Pd-Au/SiO 2 bimetallic catalysts, relative to activity, selectivity, and productivity. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm −3 , pH = 9, V O2 = 1 dm 3 ·min −1 . Images obtained by ToF-SIMS of the Pd-Au/SiO 2 catalysts showed a nonhomogeneous distribution of Au on the silica surface [ 29 ]. The bimetallic catalysts tended to form Au-enriched regions, which increased in size as more gold was introduced into the system. The distribution of the Pd fraction was better in the case of the bimetallic systems than in that of the monometallic catalyst 5% Pd/SiO 2 . Moreover, the calculated relative intensities of the Au 3 /Pd peaks revealed that the number of surface gold atoms was highest in the case of the 5% Pd-1% Au/SiO 2 system, which also showed the highest activity in the glucose oxidation reaction. This result also indicates good dispersion of Pd. On the other hand, the comparable intensities of the Pd peaks obtained for the bimetallic Pd-Au catalysts suggest that these systems had similar numbers of surface palladium atoms ( Table 2 ). It can be concluded that in the case of all the tested Pd-Au/SiO 2 catalysts the Pd atoms were similarly distributed on the support surfaces. These results of ToF-SIMS tests are in good agreement with those obtained with the XRD technique. Table 2. Intensity of the positive ion peaks 106 Pd and negative ions Au 3 obtained using the secondary ion mass spectrometry (ToF-SIMS) for bimetallic catalysts Pd-Au/SiO 2 reduced in H 2 at 300 °C. Reprinted from ref. [ 29 ]. Figure 4 shows the dependence of the relative intensities of Au 3 /Pd as a function of the Au/Pd atomic ratio in bimetallic catalysts. As can be seen, the largest number of Au atoms was measured on the catalyst surface of the 5% Pd-1% Au/SiO 2 system. This catalyst also showed the highest rate of gluconic acid formation. Thus, it can be assumed that the presence of both metals on the support may be responsible for the activity of the bimetallic system. Confirmation of good gold dispersion on the 5% Pd-1% Au/SiO 2 bimetallic system was also provided by previously conducted microscopic examinations (SEM-EDX) and CO chemisorption measurements [ 29 ]. Figure 4. Gluconic ions productivity and relative intensity of Au 3 /Pd ions as a function of the atomic ratio of Au/Pd in bimetallic Pd-Au/SiO 2 catalysts. Productivity was estimated after 2 h runs over bimetallic catalysts with various compositions of the active phase. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm −3 , pH = 9, V O2 = 1 dm 3 ·min −1 . Gluconate ions are good chelates for metal ions. Therefore, we studied the degree of leaching of Pd and Au ions from the catalysts during the glucose oxidation process. The results of inductively coupled plasma-atomic emission spectroscopy (ICP-AES) test performed on real solutions after glucose oxidation processes are presented in Table 3 . In the case of the Pd-Au/SiO 2 catalysts, leaching of Pd only was observed. The amount of Pd lost was comparable for all bimetallic catalysts. Gold was not detected in the reaction mixture when the process was conducted over bimetallic Pd-Au/SiO 2 catalysts. However, in the case of monometallic 5% Au/SiO 2 catalysts the presence of a trace amount of gold was confirmed by ICP-AES measurements. Table 3. ICP-AES analysis of the reaction mixture after catalytic tests. Reaction conditions: T = 60 °C, m cat = 1 g, C 0 = 1 mol·dm −3 , pH = 9, V O2 = 1 dm 3 ·min −1 . The application of catalysts in technological processes is economically feasible and justifiable only when they show long-term stability. For this reason, the stability of the 5% Pd-1% Au/SiO 2 catalyst, which provided the best gluconic acid productivity during the reaction of glucose oxidation in liquid phase, was investigated ( Table 4 ). The stability of the catalyst was estimated based on activity changes during 10 measurement cycles lasting 2 h each. The process of oxidation was conducted for a steady amount of catalyst (m cat = 1 g), which was not removed from the reaction mixture in the subsequent cycles. After each measurement cycle, the reaction mixture was decanted and examined by HPLC and ICP-AES. A fresh charge of glucose solution (V = 0.25 dm 3 , C 0 = 1 mol·dm −3 ) was then introduced into the reactor. The bimetallic 5% Pd-1% Au/SiO 2 system was characterized by high stability in the reaction. After 10 reaction cycles, the activity and selectivity of this catalyst were practically the same as their original values. Additionally, ICP-AES measurements of the reaction mixture executed after each cycle proved the good stability of the bimetallic systems under the reaction conditions. Only a trace amount of palladium was detected in the reaction mixture after each cycle ( Table 3 ). This high stability of the 5% Pd-1% Au/SiO 2 system in the oxidation of glucose is an advantage for industrial applications. Table 4. ICP-AES analysis of reaction mixture after stability tests of the 5% Pd-1% Au/SiO 2 catalyst. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm -3 , pH = 9, V O2 = 1 dm 3 ·min −1 . Cotton fibers consist almost entirely of cellulose (94–100%) and cotton hydrolysis therefore leads to glucose as a main product. Acidic hydrolysis of the cotton yarn was performed in a pressure reactor. Prior to HPLC analysis, samples of the hydrolysates were neutralized with milk of lime to pH 7.5, filtered through a bed of activated carbon (ERCARBON GE, 100 g), and deposited on a vacuum filter. Based on the data collected in Table 5 , it can be seen that an increase in the hydrolysis temperature from 80 to 160 °C, together with an increase in the process time from 1 to 4 h, favors the depolymerization of cellulose and the formation of larger amounts of glucose. However, analysis of the mass spectra using GC-MS techniques revealed the presence of (4.970) furfural and (8.558) 2-furanocarboxaldehyde, 5-methyl- in the sample of the hydrolysate obtained at 120 °C. Increasing the temperature up to 160 °C led to the creation of products in addition to furfural and 2-furanocarboxaldehyde, 5-methyl-: (7.885) 2(5H)-furanone, 5-methyl- and (12.438) levulinic acid. On the other hand, raising the concentration of sulfuric acid (VI), which catalyzes the hydrolysis of polysaccharides, to more than 5% did not cause further increases in the concentration of sugar in the hydrolysates. The SEM images of the solid residue after hydrolysis of the cotton fibers clearly show that the most significant change in the morphology of the fibers occurred when the process was carried out at a high temperature (160 °C). The highest concentration of glucose was also noted in this sample (0.02 mol/dm 3 ). For this reason, the hydrolyzate obtained by the reaction of 100 g of cotton fiber with 2 dm 3 of 2% H 2 SO 4 at a temperature of 160 °C for 2 h was selected for further catalytic tests. Table 5. Acidic hydrolysis of cotton fiber. In each process, 100 g of comminuted cotton yarn (>0.5 cm long) and 2 dm 3 of the solution of H 2 SO 4 (concentration 2–10%) were used. The process was carried out between 1 and 4 h in a temperature range of 80–160 °C. The degree of crystallinity of cellulose was analyzed for cotton fibers and for the solid cotton residues after hydrolysis. A simplified method (Segal peak height method) was used to estimate the crystallinity of cellulose. The results tended to overestimate the degree of crystallinity, although the relative changes in the values for crystallinity enabled a comparative analysis of the results, which are summarized in Table 5 . Increases in the degree of crystallinity of cellulose indicate more effective depolymerization of amorphous cellulose in the samples. The hydrolysate obtained from the reaction of 100 g of cotton fiber with 2 dm 3 of 2% H 2 SO 4 at 160 °C for 2 h was used as a substrate in catalytic tests. The results of glucose oxidation are presented in Table 6 . Catalytic reactions were performed over 5% Pd-1% Au/SiO 2 catalyst with three concentrations of glucose (the hydrolysate was concentrated two and four times by evaporating the solvent at 60 °C). The catalyst was used in amounts corresponding to the catalyst loading in glucose solutions of 1 mol·dm −3 ( Table 1 , m cat = 1 g, C 0 GLU = 1 mol·dm −3 , V GLU = 0.25 dm 3 ). Table 6. Conversion degree of glucose and selectivity to gluconate ions in the reaction of glucose from hydrolysates of cotton in the presence of 5% Pd-1% Au/SiO 2 catalyst. Reaction conditions: T = 60 °C, pH = 9, t = 2 h, V O2 = 1 dm 3 ·min −1 , V GLU = 0.25 dm 3 . The results confirmed the possibility of chemically processing cotton waste into sodium gluconate. 4. Discussion The addition of a second metal (Bi, Tl, Sn, Pb, Ag) to supported palladium systems is a recognized way of modifying their catalytic properties, especially selectivity, for the oxidation of aldoses (glucose, lactose) to aldonic acids (gluconic acid, lactobionic acid) [ 19 , 20 , 21 , 22 , 23 ]. However, the principles behind such modifications are still a matter of discussion in the literature [ 19 , 20 , 21 , 22 , 23 ]. Some authors have tried to define the mechanism by which gold acts as a metallic promoter of palladium-based supported catalysts [ 33 , 34 , 35 , 36 ]. Enache et al. [ 33 ] suggested that Au acts as an electronic promoter for Pd in the oxidation of primary alcohols to aldehydes, so the electronic effect is dominant. On the other hand, Roudgar et al. [ 34 ] argued that geometric effects were more important than electronic effects, when they used Pd-Au film to promote the synthesis of vinyl acetate. In turn, Baddeley et al. [ 35 ] and Gleich et al. [ 36 ] suggested that the formation of surface ensembles of Pd x Au y plays an essential role in improving reactivity. Previous studies have indicated that glucose oxidation is sensitive to the structure of the bi-metallic catalyst [ 18 , 19 , 20 , 21 , 22 , 23 ]. For this reason, the ratio of Pd atoms to Au atoms in the Pd-Au/SiO 2 bimetallic catalyst can significantly impact its catalytic properties. Among the studied catalysts with Au/Pd atomic ratios in the range of 0.0–0.55 [ 29 ], the system with an Au/Pd atomic ratio of about 0.1 (determined for the 5% Pd-1% Au/SiO2 catalyst) showed the best activity and the highest selectivity to gluconic acid. On the basis of XRD, ToF-SIMS, and previous SEM-EDS and XPS [ 29 ] studies, it was concluded that in this system these metals had the highest dispersion on the support and were also in direct contact, which explains the high selectivity of this catalyst. The addition of gold to Pd/SiO 2 catalysts led to the stabilization of small Pd particles, and to the formation a Pd-Au alloy (the composition of which strongly depended on the Au/Pd atomic ratio). Despite the fact that gluconic acid has been shown to strongly adsorb on the surface of palladium, the bimetallic 5% Pd–1% Au/SiO 2 catalyst was stable under the reaction conditions. Even after 10 reaction cycles, we observed high activity and selectivity towards gluconic acid. Thus, the addition of gold can prevent Pd poisoning, as well as improve the activity, selectivity, and stability of supported palladium systems. The research presented in this publication is a part of a larger project, which includes the development of a procedure for temperature-assisted acid hydrolysis of cotton waste and further conversion of the obtained sugars into chemical and biotechnological products. In future work, we will present a concept for acidic hydrolysis of cotton waste to sugars, which can be converted via biological processes into fuels, especially biogas rich in hydrogen. Other studies in the literature have demonstrated that cotton waste can be used for the production of ethanol, but most often the first stage is enzymatic hydrolysis of the raw material [ 37 , 38 , 39 ]. This type of hydrolysis may be effective, but it is expensive due to the high cost of enzymes. For this reason, attempts have been made to employ the cheaper method of acidic hydrolysis. Various hydrolysis strategies are available, but some of the most widely used involve treatment with either concentrated or diluted acids. Diluted acids require high temperatures [ 40 , 41 , 42 , 43 ]. Since methods for acid hydrolysis of textile waste have not been implemented commercially and the results published in the literature most often concern only acidic hydrolysis of pure cellulose, rather than cotton or textile wastes, it is necessary to perform basic laboratory tests to establish the conditions for acidic hydrolysis of well-defined textile samples and the compositions of the hydrolysates. The biological investigations currently underway will enable a precise characterization of the fermentation inhibitors present in the fabric hydrolysates. This will enable the composition and finishing of fabrics to be correlated to the composition of the hydrolysates. A model will then be elaborated for treating textile waste so it can be used as a medium in biogas installations. 5. Conclusions The transformation of organic waste into valuable chemical substances has attracted much interest, due to its great practical and commercial potential. One such transformation is the oxidation of sugars to sugar acids. Currently, the process of glucose oxidation is carried out biotechnologically with the use of Aspargilus Niger and Gluconobacter suboxydans . However, it is difficult to separate the product and remove the resulting wastewater. In order to reduce production costs, minimize the amount of waste, and simplify the technologies used, the whole process could be carried out using heterogeneous catalytic systems with the highest possible selectivities. The catalysts should be easily separable from the product, nontoxic, and resistant to deactivation. Monometallic systems have been tested in which the active phase is Pt, Pd or Au. Supported gold catalysts have the best properties, however, the preparation of systems with a high dispersion of gold requires the use of special preparative techniques. Such catalysts, despite their satisfactory activity and selectivity, are still characterized by insufficient stability during the glucose oxidation process. Similarly, the industrial application of supported polymetallic catalysts, e.g., Pd-Bi, Pd-Tl, Pd-Pb, is limited by the elution of metallic components into the reaction solution and thus their low stability. In this publication, Pd-Au/SiO 2 catalysts with different metal loadings were tested for the selective oxidation of glucose. The introduction of gold into the 5% Pd/SiO 2 system led to an improvement in its catalytic properties, especially its selectivity towards gluconic acid. The activity of the bimetallic catalysts strongly depended on the metal ratio. The highest activity and selectivity towards gluconic acid was obtained for the systems in which the Au/Pd atomic ratio was in the range of 0.05–0.15. We also investigated the long-term stability of the 5% Pd-1% Au/SiO 2 catalyst. The examined catalyst was successfully used in 10 runs with no observable decrease in activity. The 5% Pd-1% Au/SiO 2 catalyst showed very high selectivity in each of the 10 runs. The stability data for the Pd-Au/SiO 2 catalysts presented in this publication are promising, but in order for these catalysts to be used in industrial applications they require even longer stability tests. The studied Pd-Au/SiO 2 bimetallic catalysts were also found to be active in the oxidation of glucose produced from cotton waste under the conditions of pressure and temperature-assisted acidic hydrolysis. Gluconic acid was the only reaction product observed in the hydrolysates. Such gluconate-containing products made of cotton waste could be used in surface cleaning fluids or after purification, as intermediates in the cosmetics industry. Analysis of XRD, ToF-SIMS, SEM-EDS, and TPR data suggested several possible ways in which Au may influence catalytic performance. The addition of gold caused a significant increase in Pd dispersion compared to the monometallic 5% Pd/SiO2 system. At the same time, it seems to have led to the stabilization of small palladium crystallites. The bimetallic Pd-Au/SiO 2 systems, in which the dispersion of both metallic components was the highest, were characterized by high activity and selectivity towards gluconic acid. The XRD study revealed changes in the crystalline structure of the gold in the bimetallic catalysts, caused by the incorporation of palladium atoms into the crystalline structure of gold. The composition of the formed solid solution depended on the Au/Pd ratio in the bimetallic systems. 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[ Google Scholar ] [ CrossRef ][ Green Version ] Figure 1. Scheme of cotton waste management, including acid hydrolysis and further chemical and biological processes to convert glucose into useful chemical products. Figure 2. ( A ) Conversion degree of glucose X [%]; ( B ) selectivity to gluconate ions S GLC [%] of different catalysts: 5% Pd/SiO 2 ( ); 5% Au/SiO 2 ( ); 5% Pd-0.2% Au/SiO 2 ( ); 5% Pd-0.5% Au/SiO 2 ( ); 5% Pd-1% Au/SiO 2 ( ); 5% Pd-2% Au/SiO 2 ( ); 5% Pd-5% Au/SiO 2 ( ), and 1% Pt-4% Pd-5% Bi/C (Degussa) (×) as a function of time. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm −3 , pH = 9, V O 2 = 1 dm 3 ·min −1 . Figure 3. X-ray diffraction patterns for Pd-Au/SiO 2 catalysts: (1) 5% Pd/SiO 2 ; (2) 5% Pd-0.2% Au/SiO 2 ; (3) 5% Pd-0.5% Au/SiO 2 ; (4) 5% Pd-1% Au/SiO 2 ; (5) 5% Pd-2% Au/SiO 2 ; (6) 5% Pd-5% Au/SiO 2 ; (7) 5% Au/SiO 2 and the linear relationship of interplanar distances in the composition function of these systems (Vegard’s rule). The bimetallic catalysts were activated in a hydrogen atmosphere for 2 h at 300 °C. Adapted from ref. [ 29 ]. Figure 4. Gluconic ions productivity and relative intensity of Au 3 /Pd ions as a function of the atomic ratio of Au/Pd in bimetallic Pd-Au/SiO 2 catalysts. Productivity was estimated after 2 h runs over bimetallic catalysts with various compositions of the active phase. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm −3 , pH = 9, V O2 = 1 dm 3 ·min −1 . Table 1. Size of palladium and gold crystallites calculated based on XRD measurements in Pd-Au/SiO 2 bimetallic catalysts, relative to activity, selectivity, and productivity. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm −3 , pH = 9, V O2 = 1 dm 3 ·min −1 . Catalysts X * [%] S * [%] Productivity of Gluconic Ions Au/Pd [at/at] Crystallite Size [nm] *** - - [mol·h −1 ·g Pd −1 ] Au Pd 5% Pd/SiO2 21 51 1.17 0 - 21.3 5% Pd-0.2% Au/SiO2 100 90 4.94 0.02 b.d.l. 5.7 5% Pd-0.5% Au/SiO2 100 90 11.72 0.05 15.1 7.7 5% Pd-1% Au/SiO2 100 99 ** 13.57 0.11 8.4 8.2 5% Pd-2% Au/SiO2 49 95 ** 5.39 0.22 24.4 5.6 5% Pd-5% Au/SiO2 42 99 ** 4.79 0.54 41.3 5.8 5%Au/SiO2 22 70 - - 43.4 - * After 2 h of glucose oxidation. ** Gluconic acid was the only product detected by HPLC with Gilson’s prepELS II. *** Crystallite size calculated on the basis of XRD measurements. b.d.l.: Below the detection limit. Table 2. Intensity of the positive ion peaks 106 Pd and negative ions Au 3 obtained using the secondary ion mass spectrometry (ToF-SIMS) for bimetallic catalysts Pd-Au/SiO 2 reduced in H 2 at 300 °C. Reprinted from ref. [ 29 ]. Catalyst Peak Intensity Pd *·10 6 Peak Intensity Au 3 **·10 6 Relative Intensity Au 3 **/Pd * 5% Pd-0.2% Au/SiO 2 1648 42 0.025 5% Pd-0.5% Au/SiO 2 1727 38 0.022 5% Pd-1% Au/SiO 2 1961 128 0.065 5% Pd-2% Au/SiO 2 1984 71 0.035 5% Pd-5% Au/SiO 2 2062 44 0.021 * 106 Pd + ion counts/total number of positive ion counts. ** Au 3 - ion counts/total number of negative ion counts. Table 3. ICP-AES analysis of the reaction mixture after catalytic tests. Reaction conditions: T = 60 °C, m cat = 1 g, C 0 = 1 mol·dm −3 , pH = 9, V O2 = 1 dm 3 ·min −1 . Catalyst Pretreatment Steps Reaction Medium Pd [ppm] (247.6 nm) Au [ppm] (242.8 nm) 5% Pd/SiO 2 H 2 , 2 h, 300 °C Glucose 0.1148 - - H 2 , 2 h, 300 °C H 2 O b.d.l. - 5% Pd-0.5% Au/SiO 2 H 2 , 2 h, 300 °C Glucose 0.1056 b.d.l. H 2 , 2 h, 300 °C H 2 O b.d.l. b.d.l. 5% Pd-1% Au/SiO 2 H 2 , 2 h, 300 °C Glucose 0.0816 b.d.l. 5% Pd-5% Au/SiO 2 H 2 , 2 h, 300 °C Glucose 0.0798 b.d.l. 5%Au/SiO 2 H 2 , 2 h, 300 °C Glucose - 0.0257 b.d.l.: Below the detection limit. Table 4. ICP-AES analysis of reaction mixture after stability tests of the 5% Pd-1% Au/SiO 2 catalyst. Reaction conditions: T = 60 °C, m cat = 1g, C 0 = 1 mol·dm -3 , pH = 9, V O2 = 1 dm 3 ·min −1 . Number of Cycle 1 2 3 4 5 6 7 8 9 10 X [%] 100 96 97 90 92 99 96 94 99 94 S [%] 99 * 99 * 99 * 99 * 97 * 96 * 98 * 97 * 96 * 98 * Pd [ppm] 247.6 nm 0.082 0.145 0.050 0.134 0.049 0.052 0.071 0.102 0.052 0.069 Au [ppm] 242.8 nm b.d.l. b.d.l. b.d.l. b.d.l. b.d.l. b.d.l. b.d.l. b.d.l. b.d.l. b.d.l. b.d.l.: Below the detection limit. * Gluconic acid was the only product detected by HPLC with Gilson’s prepELS II detector. Table 5. Acidic hydrolysis of cotton fiber. In each process, 100 g of comminuted cotton yarn (>0.5 cm long) and 2 dm 3 of the solution of H 2 SO 4 (concentration 2–10%) were used. The process was carried out between 1 and 4 h in a temperature range of 80–160 °C. No Time [h] C H 2 SO 4 [%] Temp. [ o C] Dry Mass of Solid Residue [g] C Glucose HPLC [mol/dm 3 ] Cellulose Crystallinity of the Solid Residue [%] Product of Cotton Hydrolysis GC-MS Analysis (R.Time) SEM Images (×500 Magnification) of the Fibers after Hydrolysis 1 2 0 120 92.2 0 91 - 2 1 2 120 86.9 0.008 89 - 3 2 2 120 81.4 0.010 95 (4.970) Furfural (8.558) 2-Furanocarboxaldehyde, 5-methyl- 4 4 2 120 82.8 0.015 99 - 5 2 2 80 91.5 0 90 - 6 2 2 160 42.9 0.020 99 (4.943) Furfural (7.885) 2(5H)-Furanone, 5-methyl- (8.520) 2-Furanocarboxaldehyde, 5-methyl- (12.438) Levulinic acid 7 2 5 120 81.9 0.018 99 - 8 2 10 120 84.7 0.018 99 - Table 6. Conversion degree of glucose and selectivity to gluconate ions in the reaction of glucose from hydrolysates of cotton in the presence of 5% Pd-1% Au/SiO 2 catalyst. Reaction conditions: T = 60 °C, pH = 9, t = 2 h, V O2 = 1 dm 3 ·min −1 , V GLU = 0.25 dm 3 . Sample C 0 GLU [mol·dm −3 ] m cat [g] X [%] S GLC [%] 1 0.02 0.02 100 100 2 0.04 0.04 100 100 3 0.08 0.08 100 100 MDPI and ACS Style Binczarski, M.J.; Malinowska, J.; Stanishevsky, A.; Severino, C.J.; Yager, R.; Cieslak, M.; Witonska, I.A. A Model Procedure for Catalytic Conversion of Waste Cotton into Useful Chemicals. Materials 2021, 14, 1981. https://doi.org/10.3390/ma14081981 AMA Style Binczarski MJ, Malinowska J, Stanishevsky A, Severino CJ, Yager R, Cieslak M, Witonska IA. A Model Procedure for Catalytic Conversion of Waste Cotton into Useful Chemicals. Materials. 2021; 14(8):1981. https://doi.org/10.3390/ma14081981 Chicago/Turabian Style Binczarski, Michal J., Justyna Malinowska, Andrei Stanishevsky, Courtney J. Severino, Riley Yager, Malgorzata Cieslak, and Izabela A. Witonska. 2021. "A Model Procedure for Catalytic Conversion of Waste Cotton into Useful Chemicals" Materials14, no. 8: 1981. https://doi.org/10.3390/ma14081981 Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here . Article Metrics Export citation file: BibTeX | EndNote | RIS MDPI and ACS Style
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Remote Sensing | Free Full-Text | A Robust Photogrammetric Processing Method of Low-Altitude UAV Images Low-altitude Unmanned Aerial Vehicles (UAV) images which include distortion, illumination variance, and large rotation angles are facing multiple challenges of image orientation and image processing. In this paper, a robust and convenient photogrammetric approach is proposed for processing low-altitude UAV images, involving a strip management method to automatically build a standardized regional aerial triangle (AT) network, a parallel inner orientation algorithm, a ground control points (GCPs) predicting method, and an improved Scale Invariant Feature Transform (SIFT) method to produce large number of evenly distributed reliable tie points for bundle adjustment (BA). A multi-view matching approach is improved to produce Digital Surface Models (DSM) and Digital Orthophoto Maps (DOM) for 3D visualization. Experimental results show that the proposed approach is robust and feasible for photogrammetric processing of low-altitude UAV images and 3D visualization of products. A Robust Photogrammetric Processing Method of Low-Altitude UAV Images by Mingyao Ai 1,2 , Qingwu Hu 1,* , Jiayuan Li 1 , Ming Wang 1 , Hui Yuan 1 and Shaohua Wang 3 1 2 State Key Laboratory of Information Engineering, Surveying, Mapping and Remote Sensing, Wuhan University, Wuhan 430079, China 3 International School of Software, Wuhan University, Wuhan 430079, China * Author to whom correspondence should be addressed. Remote Sens. 2015 , 7 (3), 2302-2333; https://doi.org/10.3390/rs70302302 Received: 21 July 2014 / Revised: 8 February 2015 / Accepted: 15 February 2015 / Published: 26 February 2015 Abstract : Low-altitude Unmanned Aerial Vehicles (UAV) images which include distortion, illumination variance, and large rotation angles are facing multiple challenges of image orientation and image processing. In this paper, a robust and convenient photogrammetric approach is proposed for processing low-altitude UAV images, involving a strip management method to automatically build a standardized regional aerial triangle (AT) network, a parallel inner orientation algorithm, a ground control points (GCPs) predicting method, and an improved Scale Invariant Feature Transform (SIFT) method to produce large number of evenly distributed reliable tie points for bundle adjustment (BA). A multi-view matching approach is improved to produce Digital Surface Models (DSM) and Digital Orthophoto Maps (DOM) for 3D visualization. Experimental results show that the proposed approach is robust and feasible for photogrammetric processing of low-altitude UAV images and 3D visualization of products. Keywords: strip auto-arrangement ; BAoSIFT ; dense match ; ; unmanned aerial vehicles (UAV) Graphical Abstract 1. Introduction Low-altitude high-resolution images have great potential in many applications such as large scale mapping, true orthophoto generation, archaeology, 3D city modeling, and especially emergency response [ 1 , 2 ]. Low-altitude UAV has several advantages: flexibility, low cost, simplicity of operation, and ease of maintenance. Moreover, low-altitude UAV images provide a good alternative to satellite remote sensing and traditional aerial photogrammetry for high-resolution imagery. The typical large rotation angles of UAV images leads to no strictly predefined relationship between adjacent images, which is beyond the capability of traditional photogrammetric software [ 1 , 2 ]. Light low-altitude UAV usually embeds common single-lens reflex (SLR) digital cameras as sensors while lens distortions are simultaneously imported. The key to success of applying the remote sensing images acquired by low-altitude UAV is aerial triangulation (AT). Light small-sized UAVs are not reliable enough so that the actual flight path cannot be always as straight as that of traditional aerial photogrammetry (strip deformation ≤3% demanded by China National Standard: GB/T 6962-2005). As a result, there are usually large overlap variations and large rotation angles between adjacent images [ 2 ]. Moreover, the image frame is so small that there are many more images than in traditional photogrammetry. These factors pose the following challenges for automatic AT: (1) The identification of ground control points (GCPs) is time-consuming because of the large number of images and the irregular overlap; (2) Because of the large rotation angles, differences in scale and overlap are apparent, and the success rate of image correlation is decreased, which has a strong impact on automatic extraction and distribution of tie points, even possibly leading to the failure of AT. 2. Related Research Automated AT in traditional aerial photogrammetry is relatively mature, and a large number of commercial software packages are available in the market, for instance, Z/I Imaging’s MATCH-AT and VirtuoZo [ 3 ]. However, these software packages with standard AT procedures are imperfectly suited for orientation of images with irregular overlap acquired by UAVs. In recent years, some procedures for the automated extraction of a consistent and redundant sets of tie points from markerless close-range or UAV images have been developed for photogrammetric applications [ 2 , 4 , 5 ]. Some commercial packages have also appeared on the market (e.g., PhotoModeler Scanner, Eos Inc; PostFlight Suite, Pix4D). Some free web-based approaches (e.g., Photosynth, 123DCatch, etc. ) and open-source solutions (VisualSFM [ 6 ], Apero [ 7 ] and Bundler [ 8 ], etc. ) are also available, although generally not reliable and accurate enough in case of large and complex image blocks with variable baselines and image scale [ 9 ]. The accuracy of Global Positioning System/Inertial Navigation System (GPS/INS), usually referred to as the Position and Orientation System (POS), on the light UAV cannot be used for direct geo-referencing to satisfy the high metric quality in the surveying applications. Thus, the orientation phase can rely on an image-based approach [ 2 ]. The geometry of the topological relations between UAV images is complex; therefore, it is difficult for traditional aerial photogrammetry software (such as VirtuoZo v3.6) to generate stable tie points. To reduce the time required for image-pair matching and to decrease the number of wrong matching relationships, a variety of ideas have been proposed by different researchers. Barazzetti et al. matched ordered images with every three images composing a set and obtained tie points which are visible in more than three images, but linear accumulated error exists in this method [ 10 ]. Two ideas are proposed in another paper by Barazzetti: to obtain a visibility map between images by fast processing of thumbnail images, and to estimate image overlap using GPS/INS and Digital Terrain Model (DTM) or Digital Surface Model (DSM) [ 11 ]. Haala [ 12 ] used a method similar to the idea of obtaining a visibility map that the connection relations were obtained by processing a set of images using the open-source Bundler [ 8 ] software. The method used in this paper is similar to the second idea of estimating image overlap with GPS/INS and DTM data to generate the connection map. As for the computer vision research tasks without no accuracy requirements, distortion correction of images is not an essential step. As is known to all, the widely used “Structure from Motion (SfM)” approach put much focus on the automatic process of a large number of images, typically the match, orientation and 3D reconstruction [ 13 , 14 , 15 , 16 , 17 ]. When using photogrammetry to obtain accurate geographical information, measurable images without distortion are essential, and orientation matters for GCPs. In commercial aerial photogrammetry software, GCPs are generally recognized manually. Some software (such as LPS, Inpho, and VirtuoZo) calculates exterior orientation elements (EO) using more than three GCPs according to the collinearity equation and then calculates their positions in images by projection. There are not enough GCPs in one UAV image whose frame is small, while one control point may appear in several images. Hence, a proposed method of predicting GCPs in an image frame in this paper could improve the identification step. In most situations, the automatic AT for low-altitude UAV images is similar to that for close-range images. The Scale Invariant Feature Transform (SIFT) [ 18 , 19 ] is widely adopted to obtain scale-invariant feature points and coarse matching points in close-range images and UAV images [ 1 , 2 , 10 ]. Then, the RANdom SAmple Consensus (RANSAC) [ 20 ] algorithm with the epipolar constraint or relative orientation method can be used to remove erroneous match points. With these correct match points as initial values, other feature extraction methods like those proposed by Förstner [ 21 ] and Harris [ 22 ] can be used to obtain precise match points. Furthermore, the match points can be optimized by the least-squares matching method. Finally, EOs of the UAV images are calculated using an adjustment. This is a typical method that was presented by Zhang [ 1 ]. Other similar methods include PreSync [ 4 , 23 ] which uses directly the points matched by the Kolor Autopono software and then obtains the EO by combining initial exterior orientation parameters and reference images after several iterations; ATiPE [ 10 , 17 ], which extracts “Features from Accelerated Segment Test” (FAST) [ 24 ] interest points after using the SIFT features to carry out least-squares matching of multiple images to obtain more tie points and to improve AT accuracy. These approaches aforementioned try to improve the AT by raising the accuracy and redundancy of the tie point. Towards the same target, an improved SIFT feature extraction method and matching strategy for AT processing of UAV images is proposed in this paper. In this method, evenly distributed tie points are obtained automatically and output to the commercial block adjustment program PATB [ 25 ] for adjustment, thus eliminating the feature-point (including corner-point) extraction and matching operation following the SIFT matching step in other methods and improving efficiency. In addition, to create regional geometric networks to meet the requirements of aerial photogrammetric processing for images acquired by low-altitude weakly controlled UAV, a strip management method using UAV flight-control data to calculate connections between image pairs is proposed. To deal with distortion rectification and inner orientation of small-format non-metric UAV images of a size 10 times smaller than traditional aerial images, a parallel inner orientation-processing algorithm based on lookup tables is presented in this paper. A GCP estimation method using SIFT matching results is proposed to reduce the large workload of GCP identification in UAV images. Experiments confirm that the methods proposed in this paper are simple, convenient, and easy to implement. The structure of this article is as follows: the proposed methodology for AT of UAV images, the low-altitude UAV system, and the experimental datasets are introduced in the following section. Next, the workflow is introduced in detail in Section 4 , including the strip management method, the inner orientation method, the improved SIFT matching algorithm, the bundle adjustment (BA) calculation, and the generation and 3D visualization of Digital Elevation Model (DEM) and Digital Orthophoto Maps (DOM). Section 5 describes the experimental results of AT and the product. Conclusions and topics for further research are given in Section 6 . 3. General Strategy and Data Acquisition 3.1. Strategy When UAV is used in disaster emergencies and other emergency-response situations, it is absolutely necessary for the images to be processed immediately, and therefore a stable, easy, and efficient orientation method is of vital importance in AT. The first step in this paper is to estimate the overlapping connections of adjacent images using flight-control data. Second, a parallel algorithm based on mapping lookup tables accelerates the speed of inner orientation. An improved SIFT extracting and matching algorithm can obtain tie points from a large number of image pairs. The matching result is also used to estimate the image locations of GCPs in the GCP identification. After the matched tie points and GCPs have been transferred to the PATB software [ 25 ] for BA, the EOs of the images can be obtained. DEM and DOM can be generated with a high-density point cloud obtained by the dense point matching algorithm. According to the World Wind data organization model, 3D visualization can be implemented by overlaying of DEM and DOM. Figure 1 shows the research workflow of this paper, and the numbering indicates the section where the procedure is described. Figure 1. Workflow proposed in this paper. Figure 1. Workflow proposed in this paper. 3.2. Experimental Dataset 1: Yangqiaodian The UAV remote sensing platform used in the experiments of dataset 1 is composed of a fixed-wing aircraft, an image sensor, a programmable flight-management system with micro-POS for navigation and ground monitoring system. The UAV can fly along the scheduled trajectory taking images at locations scheduled by the programmable flight-management system that can provide the approximate position and attitude of the UAV at each exposure. As the POS is usually not precise enough as the light fixed-wing UAV is easy to be influenced by the wind, the footprints of UAV images are not the same as scheduled. The length of the vehicle is approximately 2 m, the wingspan is 2.5 m, the payload is 4 kg, and the flight speed is about 100 km/h. The remote imaging sensor on the UAV is a Canon 450D SLR camera with a fixed focal length of 24.314 mm which has been calibrated by the UAV provider. The image format is 2848 × 4272 pixels (each pixel is approximately 5.2 μm on the sensor), and the ground resolution is approximately 10 cm when the flight altitudes range from 575 to 605 m. After confirming the acquisition requirement for aerial photogrammetry data, we should make the flight plan according to the tasks to be performed and the actual terrain before the UAV flights are carried out on in field. For these experiments, images were acquired by the UAV in a hilly area named Yangqiaodian in central China. In May 2010, 854 images were acquired by the UAV system covering a hilly area in central China where the ground elevation varies from 25 to 60 m. These images belong to 17 flight strips in east-west direction. The longest flight route is approximately 4.8 km, the shortest flight route is approximately 3.4 km, the flight span is about 3.4 km, and the area is approximately 12.88 square kilometers. As shown in Figure 2 , small sharp triangles represent the image center, and the orientation of the triangles represents the flight direction. There are 45 GCPs in the experiment, and the numbers represent the identifiers of GCPs. The 33 points indicated by equilateral triangles are used as control points, while the remaining 12 points marked by circles are check points for the bundle adjustment experiments. Figure 2 shows these flight strips are not in straight lines, they compose curved lines. The flight-control data indicates that (1) the average image rotation angle in this area is 9.93°, the largest image rotation angle is 49.22°; (2) the average flight-path deviation, defined as the distance from the center of footprint to the line composed of two neighbor centers in the same flight strip, is 16.61 m, while the largest distance is 74 m; (3) the overlap of images is somewhat irregular because the maximum forward overlap is 93%, while the minimum is 67%; (4) the maximum side overlap is 75% and the minimum is 40%. Figure 3 illustrates five typical images outlined in Figure 2 . Figure 4 shows the layout of the control points. On the ground, a white circle area approximately 1 m in diameter is brushed with lime and the coordinates of the center is surveyed by the GPS Real Time Kinematic (RTK) method before the flight. The precision of the GCPs is 0.02 m, and they are identified by their centers during the post-processing. 3.3. Experimental Dataset 2: PDS This image dataset was acquired by another fixed-wing aircraft. The remote imaging sensor is a camera of SWDC-5 [ 26 ] with a fixed focal length of 82 mm which has been calibrated by the provider. The image format is 5362 × 7244 pixels (each pixel is approximately 6.8 μm on the sensor), and the ground resolution is approximately 5 cm when the flight altitudes range from 585 to 615 m. Figure 2. Schematic drawing of Yangqiaodian. Figure 2. Schematic drawing of Yangqiaodian. Figure 3. Typical images of Yangqiaodian. Figure 3. Typical images of Yangqiaodian. In May 2011, 165 images were acquired which were covering an urban area named PDS in central China where the ground elevation varies from 80–130 m. These images belong to seven flight strips in east-west direction. Eighty images are chosen for our experiment, namely the images in red rectangle in the following Figure 5 . The average of flight route is approximately 2.3 km; the flight span is about 1.5 km. There are 85 GCPs in the experimental area and their planimetric and height accuracy are approximate 0.01 m. The 14 out of 85 points indicated by red circles are used as check points for the bundle adjustment experiments. Figure 5 shows the overlap of images is somewhat irregular because of the wind during the flight. The average of forward overlap is 63% and the maximum forward overlap is 75%, while the minimum is 31%. The average of side overlap is 40% and the maximum side overlap is 50% and the minimum is 31%. Figure 6 displays several typical images of PDS dataset. Figure 4. Layout of control points in Yangqiaodian and image positions of Ground Control Points. Figure 4. Layout of control points in Yangqiaodian and image positions of Ground Control Points. Based on the layout principle of GCP in photogrammetry [ 27 ], there should be one GCP every three baselines along the flight direction and two GCPs every two baselines perpendicular to the flight direction. However, the numbers of total GCPs located in our study areas are different from the expected ones according to the aforementioned standard. This is primarily due to the actual landscape in our study areas which is highly different from the ideal situation. The recognizable obstacles including rivers, lakes, buildings, and hills make it difficult to have the distribution of GCP as the expected design with the exact calculated number. Similar situation exists in the experiments of Zhang’s paper [ 1 ]. Since such limitation cannot be avoided, we set our GCPs in the study areas according to the standard as likely as possible. Although there are slightly less GCPs in the study area of Yangqiaodian but more GCPs in the area of PDS, the overall accuracy is still acceptable and does not show significant influence on the experiments. 4. Photogrammetric Processing of UAV Images 4.1. Strip Management The weak control of our UAV platform results in irregular forward and sideways overlap, and the complex connections between the images influences matching efficiency and AT accuracy. In this research, the topological connection map of the UAV images is generated using position and attitude data obtained by the weak control system including GPS/INS unit on the low-altitude UAV platform. The images taken when the UAV is landing or turning around can be deleted according to the yaw angle (κ), and the result of this automated operation has been shown in Figure 2 and Figure 6 . The deflection angle β of an image’s center point decides whether the image belongs to a flight strip as β must be less than a given threshold determined in accordance with the low-altitude UAV digital aerial technical specifications. Figure 5. The footprints of images in the experimental area of PDS. Figure 5. The footprints of images in the experimental area of PDS. Figure 6. Typical images of PDS dataset. Figure 6. Typical images of PDS dataset. The UAV flight control data records the camera position ( Xs, Ys, Zs ), pitch angle φ, roll angle ω, and yaw angle κ at each shooting moment, which can be regarded as rough EOs of each image. Then, the field of view (FOV) of each image is calculated in geodetic coordinates via the collinear equation, as shown in Equation (1): X = X S + ( Z − Z S ) a 1 x + a 2 y − a 3 f c 1 x + c 2 y − c 3 f Y = Y S + ( Z − Z S ) b 1 x + b 2 y − b 3 f c 1 x + c 2 y − c 3 f (1) where f is the focal length (mm); Z is the average elevation of the area, which can be entered by the user or replaced by the average elevation of all the GCPs; Xs , Ys , Zs is the camera projection center under geodetic coordinates; a i , b i , c i ( i = 1, 2, 3) are nine elements from the rotation matrix calculated from each image’s φ, ω, and κ; ( x , y ) are the image coordinates of the pixels (mm); and ( X , Y ) are the corresponding geodetic coordinates. According to Equation (1), FOV of each image can be determined, and then the overlap between the images in the same strip and across strips can be calculated. In this paper, the visualization of the connection map is partly displayed in Figure 7 . A connection line between two images indicates that there is overlap between them. If there is no line between any pair of images, matching operation of this pair is skipped, which can effectively reduce the number of match operations and the matching error. Figure 7. Connections of image pairs. 4.2. Geometric Correction In this research, the coordinate transformation of corresponding image points before and after correction can be fitted with an appropriate polynomial as in Equation (2): Δ x = ( x − x 0 ) ( k 1 r 2 + k 2 r 4 p 1 [ r 2 p 2 y ) Δ y = ( y − y 0 ) ( k 1 r 2 + k 2 r 4 ) ) ( y − y (2) where ∆ x ,∆ y are the correction values of an image point; x , y are the coordinates in the image coordinate system, x 0, y 0 is the principal point, and , k 1 and k 2 1 and P 2 are tangential distortion coefficient, α and β are two scalars in the two image axes. In this paper, (∆ x , ∆ y ) [ i ][ j ] is the correction value for the image pixel ( i , j ). For a non-metric camera, when the focal length is fixed, the lens distortion is a component of system error; it has the same effect on each UAV image. The lookup table-based distortion correction algorithm proposed in this paper corrects one image at a time with the same distortion parameters. The first UAV image is corrected by using the proposed distortion model, and all the correction value (∆ x , ∆ y ) [ i ][ j ] for all the image pixels are calculated and stored in a two-dimensional lookup table Array [ W ][ H ] , whose size is the same as the image. Then, the rest of the UAV images are corrected using the two-dimensional lookup table without calculating the correction values pixel by pixel. This lookup table accelerates image-distortion correction and avoids a mass of duplicate calculations. To enhance efficiency, the OpenMP (Open Multi-Processing) [ 28 ] parallel processing technology is introduced in the accelerated distortion-correction algorithm. In OpenMP , many CPUs can work together to correct distortion, and one CPU deals with one image at a time. A computer with a dual-core 2.80 GHz CPU and 2.00 GB memory is used to perform the experiment. Thirty images from the Yangqiaodian area are chosen for distortion removal with a direct distortion correction without any improvement, the lookup table-based distortion correction algorithm, and the parallel lookup table-based interior orientation method proposed in this paper. Table 1 shows the time required by these three methods. Table 1. Time required by the three methods. Table 1. Time required by the three methods. Method First Image (s) Remaining Images (s) All (s) Direct distortion correction 10.4 10.4 314.0 Lookup table-based distortion correction algorithm 10.4 6.0 182.7 Parallel lookup table-based interior orientation method 5.8 3.4 104.4 As shown in Table 1 , the time required by the lookup table-based distortion correction algorithm is reduced by 42.3% compared to the direct one. The efficiency of the parallel lookup table-based interior orientation method is enhanced more than threefold compared to the direct algorithm because it makes full use of the advantages of multi-core computing and of the lookup table algorithm. The method presented here achieves a great difference in UAV image processing by improving image-distortion correction efficiency linearly. In this research, feature extraction, image matching, BA, mapping, and other follow-up operations are performed on the corrected images. 4.3. Image Matching Strategy The image tie points should be evenly distributed for BA, strictly should be distributed in the region centered at the von Gruber locations [ 29 ]. In practice, this is not achieved when the UAV image match points are obtained by the original SIFT matching algorithm. The SIFT algorithm includes three steps: extracting the feature points, matching the feature points to obtain the initial matching correspondences, and removing the error correspondences with geometric constraints. In this research, the first and third steps of the algorithm are improved to obtain distributed correspondences. One image pair at a time is selected according to the image connections obtained in Section 4.1 . The initial match results indicate whether there is overlap between the small-size blocks in the image pair distributed as von Gruber locations. The SIFT feature points are extracted using a block-adaptive multi-threaded accelerated strategy. Only SIFT feature points in the overlapping image blocks are then used to search correspondences. At last, the geometric constraint is optimizing the results. This matching strategy, called Bundle Adjustment Oriented SIFT (BAoSIFT), is illustrated in Figure 8 . The multi-view verification strategy that will shortly be described is used to obtain multi-overlap tie points for BA. The image transformation obtained by image matching can also be used to predict GCP positions and to improve the efficiency of GCP identification in the images. Figure 8. BAoSIFT matching workflow. Figure 8. BAoSIFT matching workflow. BAoSIFT Feature Extracting: The adaptive feature number threshold ( T ) for each block in one image can be the weighted average of the numbers of features in all blocks, as the number of feature points in each block should be relevant to the content or texture of the block, which is estimated by its information entropy in this paper. This hypothesis results from the von Gruber points [ 29 ] and the fact that the UAV image size is so small that the covered landscape varies little. Therefore, each von Gruber region should retain tie points and these points should be evenly distributed, which results in evenly distributed points in each image. The rule governing the number of SIFT feature points and the parameters of the original SIFT feature-extraction algorithm are the foundation of this algorithm. The steps of BAoSIFT feature extraction may be described as follows: (1) Configure the default parameters of the SIFT feature-extraction algorithm or obtain the parameters from the users, including the number of blocks in the images, which is generally the number of cell rows and columns in one image. In our experiment, the images were divided into five rows and three columns with a total 15 cells shown in the top right corner of Figure 8 , and an image block was 800 × 800 pixels in the center of the image cell; as such, there are 15 blocks in one image; This division is based on demand of the von Gruber locations in the traditional aerial photogrammetry; (2) Calculate the sizes of the blocks and their positions in the image according to the image size and parameters; (3) Extract SIFT features from the blocks; calculate the weighted average of the numbers of features in the blocks as T with the Equation (3): T = ∑ ib = 1 n H i b × N i b n H = − ∑ i = 0 L − 1 P i log 2 P i (3) where n is the number of blocks in one image; N ib is the number of features in block ib ; H ib is the image information entropy of block ib , calculated by the second formula; P i is the probability of gray level i ( i = 0,1,…,255) in the block ib ; L equals 256 in our experiment; (4) If the number of features in one block is less than T , then go to step (5), otherwise extraction of this block is finished, go to step (7); (5) Modify the parameters of the SIFT feature-extraction algorithm in accordance with the current number of points, then go to step (6). (6) Redo the extraction on the image block with the new parameters, and continue to step (7) whether the number of features is less than T or not; (7) Finish extracting for the image. In this improved feature extraction algorithm, feature extraction for each image block is not performed more than twice. Before and after the average is calculated, these blocks in one image are processed in parallel using the multi-threaded technique. Block matching strategy: The block matching strategy of coarse-to-fine is adopted to match the feature points extracted by the BAoSIFT feature extraction algorithm. This strategy is showed in Figure 6 . At first, the coarse matching operates the resampled images of the size less than 1000 × 1000 pixels. SIFT Features are extracted and matched from the resampled images to obtain the pixels mapping parameters to judge the overlap of blocks on the original image pair. Second, unlike the strategy to match the features in the whole image presented in the paper of Huo [ 30 ], we just extract features from the blocks distributed as von Gruber regions in the original corrected image with the BAoSIFT Feature Extracting method and search initial match correspondences between the overlapped block pair. Then, RANSAC and geometric constraints, homography geometry in our BA experiment, are combined to eliminate false match correspondences in the overlapped block pair. These operations of BAoSIFT feature extracting and correspondences matching are repeated on the block until all the overlapped blocks in one image pair have been processed. Finally, a simple geometric constraint, actually the 3σ rule by counting the parallaxes of the correspondences in the BA experiment, is used to perform overall optimization and to remove false match points in non-overlapping blocks obtained due to repeating textures. Simple multi-view verification: To each correspondence, the same ID is assigned, and this ID is also assigned to other points in other images which meet the matching requirements with either of this pair of correspondences. The actual procedure may be complex; Figure 9 shows a simple case of five images, Photo 1 to Photo 5. The links in Figure 9 indicate the correct corresponding points after matching constraint validation. Then IDs are assigned to these correspondence pairs, like the numbers in the figure. The ID 2 points appear in two images, ID 5 and ID 6 points are four overlapping tie points, and the others are three overlapping tie points. Although this method is simple, it is very practical in our experiment. The overlap of each correspondence, which is the number of each ground point’s visibility in the images, is counted simultaneously. After all matched points are assigned ID, low overlap points are deleted. In our experiment, points with less than three-lap along the flight direction are not exported for BA. We adopt this operation based on the fact that points with two-lap along the flight direction, like point with ID 2, are only used for the relative orientation, while high overlap tie points can be used for continuous relative orientation, and the points with two-lap across the flight can be used for connecting adjacent flight strips. This fact makes the geometric network of BA more stable. Figure 9. Simple multi-view matching algorithm. Figure 9. Simple multi-view matching algorithm. After the tie-point connection procedure above, a large number of precise image tie points can be obtained for BA. 4.4. Ground Control Point Prediction The Ground Control Point Prediction can be expressed by Equation (4): X 2 Y 2 1 ] = M [ X 1 Y 1 1 ] (4) where M is the transformation. It is a 3 × 3 matrix, and it is invertible. If the transformation is precise, the calculation can be continuous. The M matrices between every two overlapping images can be calculated using the image-matching result, and then the corresponding points in other images can be predicted. To deal with UAV images with POS data, the loss of some GCPs in certain images can be reduced thanks to the combination of POS data and matching results, in this way, the efficiency can be improved. The visibility of GCPs in an image can be estimated with POS data using the method described in Section 4.1 . Moreover, the transformation obtained by the matching results also contributes to the estimate and can map to the GCP positions in other images. As Figure 10 shows, once the GCP labeled “111” in the image “1008.tif” (the middle one in the top row in the figure) has been identified, then its corresponding points in other images (in the same flight strip, 1007.tif, 1009.tif, 1010.tif; in the above adjacent flight strip, 2009.tif, 2010.tif) around the current image can be predicted automatically according to the POS data and the transformation. The lower right corner of each image is the enlarged picture. This enlarged picture shows that the predictions in the current and adjacent flight strips are both relatively accurate. Then, the point is manually moved to the center of the white circle, and the identification is finished. This prediction contributes to the efficiency of identification. Figure 10. Rapid control-point prediction based on POS data and SIFT matching. Figure 10. Rapid control-point prediction based on POS data and SIFT matching. The GCP prediction method proposed in this paper does not require more than four control points which are necessary if the back-intersection is used to predict the GCP. This offers an alternative to reduce the workload of identifying GCPs. 4.5. Bundle Adjustment To perform bundle adjustment, the GCPs and their identical image positions, and the matching tie points in the images obtained by the algorithms as described in Section 4.3 and Section 4.4 are organized in the PATB input file format. Then, the PATB takes on the task of bundle adjustment. As the images are corrected for distortion, there is no need to use the self-calibrating bundle adjustment. The PATB software provides the EOs of each image and the tie points’ geodetic coordinates. 4.6. Dense Matching and Generation of Digital Surface Models (DSM) and Digital Orthophoto Maps (DOM) DSM can be generated by dense image matching or by human–computer interaction. The points obtained by human interaction are sparse and need further manual editing to generate accurate DSM. The PMVS (Patch-based Multi-view Stereo Software) [ 31 ] was improved to perform dense matching in this research. As PMVS on a single computer cannot handle many images at one time, the images are grouped, and each group of images is used with PMVS to generate a dense point cloud and then merge these point clouds into a point cloud of the entire survey area. The first step of PMVS is to generate seed points by matching Harris and Difference-of-Gaussian (DOG) features. This time-consuming step is omitted, and the match points obtained as described in Section 4.3 are used as seed points after initialized, followed by extensions and filters as the second and third step of PMVS to acquire the dense point cloud. The dense point cloud is interpolated to generate the DEM. The procedures are shown in Figure 11 . Then, orthophotos are obtained by orthorectification with the DEM and the corrected images, and all the orthophotos mosaic to form a single DOM. Figure 11. Procedure for dense matching. Figure 11. Procedure for dense matching. 4.7. Three-Dimensional Visualization The last task is to show the DEM and DOM, both are 0.1 m high-resolution. There are several free softwares for 3D visualization of DEM and DOM, such as World Wind, Virtual Terrain Project and osgEarth. We adopt the World Wind which is an open-source software package developed by the United States National Aeronautics and Space Administration (NASA). World Wind can manage multi-source geospatial data, their distribution, and their three-dimensional visualization [ 32 ] and solves the vital problems of seamless integration, management, and highly efficient display of multi-source geospatial data (DOM, DEM, KML) and other third-party data. This paper achieves three-dimensional visualization by adapting the DEM and DOM to the World Wind data model. The images and elevation data that World Wind supports are organized as a pyramidal model, and therefore we develop a data-processing tool to cut DEM and DOM into slices and blocks and transform these tiles to the file format of World Wind’s data model. 5. Results and Discussion Low-altitude UAV images and GCPs were used as sources for experiments on the proposed approaches to photogrammetric processing. The operation of selecting gross error points through human–computer interaction during AT is not included in the experiment. Instead, matching operation for tie points are directly input for bundle adjustment to obtain EOs. The matching algorithm is discussed, the precision of AT (squared error), the 3D coordinates of matched tie points and dense point cloud, DEM, and DOM are also displayed in this section. 5.1. Image Matching 5.1.1. Efficiency and Distribution of Features Given the same size of the input images, the performance of feature extraction is mainly determined by the block size, and this relation can be measured quantitatively. In this experiment, we choose the first typical image in Figure 3 as the put image to compare the performance and number of features extracted by the original SIFT, BAoSIFT, and BAoSIFT MT, short for BAoSIFT accelerated by multi-thread, as shown in Table 2 . As the original SIFT has the problem of large memory requirement and computational complexity, we extract features in blocks of the input image in the experiment. At the same time, we get different numbers from different block sizes without considering the impact of edge, because the edge leads to the problem that more blocks and more pixels are ignored to extract features on the edges of blocks. The experiment shows the best compromise is achieved when the block size is 512 × 512, considering the time and number of features. We also find that this comparison of BAoSIFT and BAoSIFT MT demonstrates the advantages of parallel multi-thread in improving the efficiency, despite the same numbers of their features. Moreover, the improved BAoSIFT algorithm really increases the number of features. The comparison in Figure 12 shows the advantage of the BAoSIFT in the spatial distribution of the extracted points over the original SIFT algorithm. Table 2. Comparison of SIFT to BAoSIFT. Table 2. Comparison of SIFT to BAoSIFT. BlockSize SIFT BAoSIFT BAoSIFT MT Time (ms) Number of Features Time (ms) Number of Features Time (ms) 64 × 64 5007 9925 8018 12,749 2340 128 × 128 5054 12,203 8053 15,037 2424 256 × 256 5504 13,594 8081 16,606 2605 512 × 512 5679 14,209 8346 16,951 2659 1024 × 1024 5959 14,628 8736 17,635 2715 Figure 12. Features are extracted from the first typical image of Figure 3 . ( a ) The features extracted by the original SIFT in the center of the experimental image; ( b ) the features extracted by BAoSIFT; both block sizes are 512 × 512. Figure 12. Features are extracted from the first typical image of Figure 3 . ( a ) The features extracted by the original SIFT in the center of the experimental image; ( b ) the features extracted by BAoSIFT; both block sizes are 512 × 512. 5.1.2. Feature Matching The matching method proposed in this paper could obtain more than 1000 stable image-matching points per image pair. Table 3 and Figure 13 show matching results for the same stereo image pair using different matching strategies. In Figure 11 , the crosses represent matching points. Figure 11 a represents the result achieved by SIFT feature extraction and then by removing the error correspondences with the combination of RANSAC and homography constraints. The number of matching point pairs is 631; Figure 11 b represents the results of the improved method presented in this paper. The images are divided into five rows and three columns, and an 800 × 800 pixels block in the center of each cell is considered as an image block to extract BAoSIFT features. All the features of the small overlapped block pairs in the image pair are matched using RANSAC and homography constraints, and finally a simple optimization of 3σ rule is performed by counting the parallaxes of the correspondences overall. This optimization deletes the correspondences with the high parallax out of range defined by three times of the standard deviation. The number of matches is 1381; Figure 11 c is almost the same as Figure 11 b, but does not use the small images to estimate the overlaps. The number of matches is 3845; Figure 11 d is mostly identical to Figure 11 c, the only difference is the optimization with constraint of epipolar geometry, and the number of matches is 3371; After manual checking, the correspondences found by Figure 11 a,b,d are all determined to be correct, while error exists in Figure 11 c. There are obviously errors scattered in the left part of the left image and in the right part of the right image; in addition, error correspondences exist in other places. The homography constraint is a kind of plane constraint, which means that ground objects corresponding to identical points in the image pairs should lie in the same plane. Figure 13 a shows this phenomenon that there are only matched features in the low right part of the pair. The method combining RANSAC and homography constraints tries to robustly find the plane, and tries to contain the most points. However, this plane constraint limits the distribution of the matched features. While the result of epipolar geometry covers the overlapped region of the image pair, there exist errors, as shown in Figure 13 c. So, the proposed method combines their virtues. Each overlapped block pair finds the plane that contains the most points. The block-matching strategy essentially obtains matching points belonging to different planes, and therefore the number of matching points is increased. Meanwhile, the partition of transforming one image to several blocks is based on the von Gruber locations. And the result is that points are distributed more evenly to cover the image with the help of epipolar constraint, which has been proved in Figure 13 b–d. The step of resampled image matching for obtaining the pixels mapping parameters is beneficial to judge the overlap of blocks on original image pair. This judgment reduces the time of processing non-overlapped blocks. Figure 13. Matching result for UAV images: ( a ) remove error correspondences with the combination of RANSAC and homography constraints; ( b ) the improved method presented in this paper; ( c ) does not use the small images to estimate the overlaps; ( d ) optimization with constraint of epipolar geometry to remove the error correspondences based on the results in ( c ). Figure 13. Matching result for UAV images: ( a ) remove error correspondences with the combination of RANSAC and homography constraints; ( b ) the improved method presented in this paper; ( c ) does not use the small images to estimate the overlaps; ( d ) optimization with constraint of epipolar geometry to remove the error correspondences based on the results in ( c ). Table 3 shows the time taken for different strategies. The matching efficiency of the method used in (a) is the highest, but the matching points are unevenly distributed; The time required for (b) is three times that for (a); This time is mainly used to search for matching points, but the matching points are distributed relatively evenly according to the von Gruber points; The efficiencies of (c) and (d) are almost the same, and the matching points are evenly distributed in the overlap area of the stereo pairs, but the time required is far more than for (b); Method (b) therefore represents a good compromise between efficiency and distribution of matching points. Table 3. Efficiency of different strategy of blockwise match. Table 3. Efficiency of different strategy of blockwise match. Method a b c d Number of Correspondences 631 1381 3845 3371 Time(ms) 2558 8074 72,649 73,415 Actually, as the overlap of UAV images is irregular, one image can overlap several images (more than four images). If method (b) described above is only used, one image still shares tie points with other images. Therefore, the tie points finally lying in one image still cover the full image. As shown in Figure 14 , the image pair is the same one shown in Figure 13 . Figure 14 also shows the difference of quantity and distribution between the matching results obtained by using method (a) and (b); Most correspondences of method (b) concentrate in the image. These tie points are vital for AT because they ensure, not only that enough redundant observations are obtained, but also that all the images are connected. This method gets all the correspondences for BA in our experiment. Figure 14. Final results of image matching obtained by using method ( a ) and ( b ). Figure 14. Final results of image matching obtained by using method ( a ) and ( b ). 5.2. Bundle Adjustment To evaluate fully the accuracy of the workflow proposed in this paper for low-altitude images, BA experiments with GCPs are performed with the two datasets Yangqiaodian and PDS, respectively. The free software VisualSFM [ 6 ] is adopted to compare the precision of AT. Coming from the Computer Vision community, VisualSFM is not a photogrammetric software application and does not use control points as constraints in the bundle but only for a posteriori rigid Helmert transformation (scale and geo-referencing). However, VisualSFM has been adopted for UAV and close range image orientation. 5.2.1. Yangqiaodian Two methods are adopted to generate the tie points—the original SIFT and BAoSIFT—namely the Method (a) and (b) in Figure 13 . During the procedure of both methods, features are extracted by using parallel multi-thread with the block size of 512 × 512. During the matching procedure of BAoSIFT, images are divided into five rows and three columns (15 cells), and 800 × 800 pixel block in the center of each image cell is processed. Of the 1,337,667 tie points with the overlap, more than two are finally obtained, while the original SIFT obtains 896,495 tie points without two-lap points being discarded. After identifying the GCPs and BA by PATB, the AT results were as displayed in Table 4 . The SIFT and BAoSIFT approaches use the same GCPs, check points and the setup of BA. The root-mean-square values (RMS) of GCPs and check points of results of the BAoSIFT is better than those of SIFT. On the whole, Table 4 shows advantages of BAoSIFT over SIFT in the RMSs of GCPs and check points. The RMSs of GCPs and check points in Table 4 demonstrate the rationality of the successful result, compared to the original SIFT method. In order to compare the results of AT, the geometrical corrected images and the GCPs are fed to the free software VisualSFM, which uses SIFT for feature extracting and matching as well. After exhaustive pair-matching ( n × ( n − 1)/2, n is the number of images) and BA, the free software VisualSFM obtains the oriented results and 3D points corresponding to these tie points. In particular, the tie points with at least three-lap are required for BA of VisualSFM. It is worth noting that the statistical results from VisualSFM are processed by space intersection with multi-image due to the lack of statistical reports in object space provided by the software. At the same time, the software PATB prompts that it cannot process the input image points delivered by VisualSFM when we use these matched tie points. Table 4 shows the lower precision obtained by VisualSFM than that of SIFT and BAoSIFT. Table 4. Precision of AT in the Yangqiaodian area. Table 4. Precision of AT in the Yangqiaodian area. Method Control Points (m) Check Points (m) Evaluation Max (ΔX) Max (ΔY) Max (ΔZ) RMS (X) RMS (Y) RMS (Z) Max (ΔX) Max (ΔY) Max (ΔZ) RMS (X) RMS (Y) RMS (Z) SIFT ( a) 1.51 0.61 0.97 0.3 2 0.2 4 0.5 4 0.57 0.37 0.83 0.2 3 0.2 2 0.5 1 BAoSIFT ( b) 0.42 0.38 0.74 0. 17 0. 17 0. 38 0.32 0.26 0.55 0. 16 0. 17 0. 36 VisualSFM 1.21 0.98 1.33 0.65 0.56 0.82 1.42 1.01 1.46 0.78 0.68 0.91 It is well known that the result of AT is affected by many factors, such as the accuracy and distribution of GCPs, the number and distribution of tie points, overlaps between images, the base-to-height ratio. In this study, the only difference is the matching method, which results in different overlap, numbers and distribution of tie points. Therefore, we add the numbers of tie points in all the images as follows. As the size of image is 2848 × 4272, we divide the image into 178 × 267 grids with the size of 16 × 16 pixels (16 is their greatest common divisor). Then, we count the number of tie points within each grid. The statistical results are shown in Figure 15 , which shows the number of tie points of each grid. The present block edges (blue grid lines) demonstrated in Figure 15 have no tie points attributed to the implementation of Feature Extracting algorithm designed for the block size 512 × 512. It is worth noting that the original SIFT method is also based on the same block-multi-thread strategy with BAoSIFT to avoid the different processings. Except for the aforementioned edges in Figure 15 a,b, the tie points resulted from the BAoSIFT method present a higher level of coverage compared with those by the original SIFT method shown in Figure 15 c. This can be confirmed by the positive results obtained based on the reduction of BAoSIFT and SIFT in Figure 15 c. Even when we increase the point size of Figure 15 a by 1.5 times, the result in Figure 15 d still indicates the same conclusion as Figure 15 c. Figure 15 proves the advantages of the BAoSIFT method in characterizing the overlap, number and distribution of the tie points over the SIFT method. This is also the reason that BAoSIFT gains higher precision of BA compared with the SIFT method. The error distribution of GCPs and check points will show the rationality once more. Figure 16 shows the GCPs’ error distribution of the result of SIFT and BAoSIFT. Lines at each point represent altitude error, the orientation of the lines represents the orientation of the plane error (atan(d y /d x )), and the circles represent the values of the plane error. The GCPs with relatively large errors are mostly distributed on the edge of the area, shown in both results of Figure 16 . The upper left and the bottom parts in both of the two figures have large features. This similarity of distribution of error shows the two methods’ rationality. Figure 15. The comparison of BAoSIFT and SIFT methods in generating tie points in the study area of Yangqiaodian. ( a ) SIFT; ( b ) BAoSIFT; ( c ) BAoSIFT-SIFT; ( d ) BAoSIFT-1.5 × SIFT. Figure 15. The comparison of BAoSIFT and SIFT methods in generating tie points in the study area of Yangqiaodian. ( a ) SIFT; ( b ) BAoSIFT; ( c ) BAoSIFT-SIFT; ( d ) BAoSIFT-1.5 × SIFT. The PATB software obtains 3D coordinates for the ground points corresponding to the tie points, as shown in Figure 17 . This figure shows the distribution of the ground points corresponding to the matched image features acquired by BAoSIFT. This figure also shows these points cover the experimental area, and there are no large gaps except for water regions. Figure 16. Error distribution of GCPs and check points in Yangqiaodian. ( a ) SIFT; ( b ) BAoSIFT. Figure 16. Error distribution of GCPs and check points in Yangqiaodian. ( a ) SIFT; ( b ) BAoSIFT. Figure 17. 3D point cloud for the Yangqiaodian area. Figure 17. 3D point cloud for the Yangqiaodian area. 5.2.2. PDS To further demonstrate the BAoSIFT algorithm, three methods are adopted to generate the tie points, the original SIFT, BAoSIFT, namely the Method (a) and (b) in Figure 13 of the manuscript, and VisualSFM. The matching procedure of BAoSIFT includes the same operations as those in the experimental dataset of Yangqiaodian: images are divided into five rows and three columns (15 cells), and an 800 × 800 pixel block in the center of each image cell is processed. In total, 16,244 tie points with the overlap of more than 2 are finally obtained by BAoSIFT, while 100,482 tie points are acquired by the original SIFT method. After identifying the GCPs and BA by PATB, the AT results are revealed in Table 5 . The SIFT and BAoSIFT approaches use the same GCPs, check points and the configurations of BA. VisualSFM shares the same GCPs and check points with the other two. The root-mean-square values (RMS) of GCPs and check points of results of the BAoSIFT are better than those of SIFT and VisualSFM. VisualSFM obtained the lowest precision. We also use PATB to bundle-adjust the tie points generated by VisualSFM with the same GCPs, check points and the configurations of BA as the SIFT and BAoSIFT approaches do. Table 5 shows the exhaustive pair-matching of VisualSFM, ( n × ( n − 1)/2, n is the number of images) achieves better precision than the original SIFT in our manuscript, but worse precision than BAoSIFT. The difference between the three approaches also results from the different overlap, numbers and distribution of tie points. Table 5. Precision of AT in the PDS area. Table 5. Precision of AT in the PDS area. Method Control Points (m) Check Points (m) Max Std Max Std X Y Z X Y Z X Y Z X Y Z SIFT 0.140 0.114 0.657 0.035 0.032 0.189 0.142 0.052 0.437 0.048 0.025 0.167 BAoSIFT 0.135 0.070 0.192 0.021 0.019 0.042 0.132 0.046 0.231 0.039 0.019 0.070 VisualSFM 0.530 0.640 0.810 0.180 0.240 0.430 0.470 0.610 0.980 0.160 0.190 0.520 VisualSFM-PATB 0.149 0.056 0.842 0.025 0.024 0.140 0.139 0.055 0.589 0.038 0.027 0.159 In this experimental dataset, we also compare the distribution and overlap of tie points using the same method that we divide the images into grids with the size of 16 × 16 pixels. Then, we summarize the numbers of tie points within the same grid. The statistical results are displayed in Figure 18 , which demonstrates that BAoSIFT obtains many more tie points than SIFT at von Gruber locations. This is the key difference of the two methods, which leads to the different results from BA. Figure 18. The comparison of BAoSIFT and SIFT methods in generating tie points in the study area of PDS. ( a ) SIFT; ( b ) BAoSIFT; ( c ) BAoSIFT–SIFT. Figure 18. The comparison of BAoSIFT and SIFT methods in generating tie points in the study area of PDS. ( a ) SIFT; ( b ) BAoSIFT; ( c ) BAoSIFT–SIFT. Figure 19 shows the GCPs’ error distribution of the results from SIFT and BAoSIFT. The error distribution of the two approaches share some features that most of the GCPs and check points have little error, and the plane error of two points in the center is relatively large. Figure 19. Error distribution of GCPs and check points in PDS. ( a ) SIFT; ( b ) BAoSIFT. Figure 19. Error distribution of GCPs and check points in PDS. ( a ) SIFT; ( b ) BAoSIFT. 5.3. 3D Visualization of Digital Elevation Model (DEM) and Digital Orthophoto Maps (DOM) With the help of improvements to the NASA World Wind open-source software, a three-dimensional display could finally be realized, as the 3D scene of Yangqiaodian area shown in Figure 21 . All the corrected images are grouped to calculate the dense point cloud, and then these point clouds are merged into one point cloud for generating the DSM. The whole DEM dataset of the area is obtained by filtering the DSM. All of these corrected images are orthorectified into DOM. The DEM and DOM of the area are overlapped to form the visual 3D scene, shown in Figure 21 . Figure 20. From dense point cloud to orthophoto: ( a ) Colorful dense point cloud generated by PMVS; ( b ) Orthophoto generated based on dense point cloud and corrected image. Figure 20. From dense point cloud to orthophoto: ( a ) Colorful dense point cloud generated by PMVS; ( b ) Orthophoto generated based on dense point cloud and corrected image. 6. Conclusions Experimental results show that the method proposed in this paper is effective and feasible for UAV images. With the proposed methods, localization and orientation of UAV images could be achieved with low cost. It can be concluded that the proposed methods have great potential in surveying and mapping and emergency disaster response. The automated strip arrangement described in the paper is able to process rough flight data and to calculate the FOV of images. Thus, overlaps and connections can be obtained, which save the matching time for stereo image pairs with large rotation angles and irregular overlaps and reduce the matching error effectively. Based on the consistency of the distortion of each image, correction could be carried out by means of the lookup-table technique. Furthermore, the efficiency of distortion correction can be improved significantly by OpenMP. Large quantities of evenly distributed matching points could be found from UAV image pairs with the BAoSIFT. With the GCP prediction method proposed in this paper, the identification workload can be reduced significantly. The results of the BAoSIFT matching algorithm and the GCP coordinates are output directly to PABT to carry out the AT calculations, which implement automatic AT processing for the large-rotation, small-format images acquired by low-altitude UAVs. DSM and DOM can be obtained after orientation to provide 3D visualization on World Wind. Figure 21. 3D visualization of Yangqiaodian with the help of improved World Wind. Figure 21. 3D visualization of Yangqiaodian with the help of improved World Wind. Although multithread technology has been used in this research to improve the efficiency of SIFT feature extraction, the computing time of SIFT is huge, and the efficiency of SIFT feature extraction still needs to be improved. Improving the extraction and the matching algorithm combined with other features will be a focus of future research. The integration of rough flight data into the aerial bundle adjustment to make full use of flight data and improve efficiency is also an important future research topic. The rule of affect for the distribution of tie points on the BA is yet to be determined by researchers. Acknowledgments The authors would like to express their gratitude to the editors and the reviewers for their constructive and helpful comments for substantial improvement of this paper. This work is supported by National Basic Research Program of China (973 Program, No. 2012CB725300), and National Natural Science Foundation of China (No. 41271452 and No. 41271431). Author Contributions Mingyao Ai wrote the main program and most of the paper; Qingwu Hu conceived the study and designed the experiments; Jiayuan Li studied the improved PMVS; Ming Wang was responsible for the part of Geometric Correction; Hui Yuan participated in auto-management of aerial strips; Shaohua Wang contributed to manuscript preparation. Conflicts of Interest The authors declare no conflict of interest. References Zhang, Y.; Xiong, J.; Hao, L. Photogrammetric processing of low-altitude images acquired by unpiloted aerial vehicles. Photogramm. Rec. 2011 , 26 , 190–211. [ Google Scholar ] [ CrossRef ] Remondino, F.; Barazzetti, L.; Nex, F.; Scaioni, M.; Sarazzi, D. UAV photogrammetry for mapping and 3d modeling–current status and future perspectives. In Proceedings of the International Conference on Unmanned Aerial Vehicle in Geomatics (UAV-g), Zurich, Switzerland, 14–16 September 2011. Laliberte, A.S.; Herrick, J.E.; Rango, A.; Winters, C. 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Applied Sciences | Free Full-Text | Seismic Upgrading of Existing Reinforced Concrete Buildings Using Friction Pendulum Devices: A Probabilistic Evaluation In many countries around the world a huge number of existing reinforced concrete (RC) structures have been realized without account for seismic detailing, even if they are located in areas subjected to high seismicity. In this context, several passive seismic protection techniques have been developed and applied to retrofit these structures such as, for an example, seismic isolation. The aim of this work is to characterize in probabilistic terms the seismic performance of a framed RC building retrofitted by means of sliding friction pendulum (FPS) devices. Specifically, the response of an existing RC building located in a high seismicity area in Italy is investigated. After the description of the main available information about the structure, a non-linear numerical model has been defined by means of fiber-elements approach. Then, non-linear dynamic analyses considering multiple recorded ground motions with the three accelerometric components have been carried out to assess the seismic response of the building with and without the retrofitting intervention composed of FPS isolators. Finally, the results are processed to achieve a probabilistic assessment of the seismic performance of the retrofitting intervention. Seismic Upgrading of Existing Reinforced Concrete Buildings Using Friction Pendulum Devices: A Probabilistic Evaluation Diego Gino , Costanza Anerdi , Paolo Castaldo * , Mario Ferrara , Gabriele Bertagnoli and Luca Giordano * Author to whom correspondence should be addressed. Appl. Sci. 2020 , 10 (24), 8980; https://doi.org/10.3390/app10248980 Received: 27 November 2020 / Revised: 13 December 2020 / Accepted: 14 December 2020 / Published: 16 December 2020 (This article belongs to the Special Issue Structural Reliability of RC Frame Buildings ) Abstract In many countries around the world a huge number of existing reinforced concrete (RC) structures have been realized without account for seismic detailing, even if they are located in areas subjected to high seismicity. In this context, several passive seismic protection techniques have been developed and applied to retrofit these structures such as, for an example, seismic isolation. The aim of this work is to characterize in probabilistic terms the seismic performance of a framed RC building retrofitted by means of sliding friction pendulum (FPS) devices. Specifically, the response of an existing RC building located in a high seismicity area in Italy is investigated. After the description of the main available information about the structure, a non-linear numerical model has been defined by means of fiber-elements approach. Then, non-linear dynamic analyses considering multiple recorded ground motions with the three accelerometric components have been carried out to assess the seismic response of the building with and without the retrofitting intervention composed of FPS isolators. Finally, the results are processed to achieve a probabilistic assessment of the seismic performance of the retrofitting intervention. Keywords: seismic isolation ; existing building ; probabilistic analysis ; non-linear dynamic analysis ; reinforced concrete 1. Introduction Nowadays, in many countries such as Italy, the assessment of existing structures and infrastructures [ 1 ] is a relevant issue and particular care should be pointed out to areas with a high seismic hazard. In fact, during the 60s and 70s many of today’s existing reinforced concrete (RC) buildings were built without any seismic criterion or with poor detailing in comparison to the current codes [ 2 ]. In fact, most of the existing constructions, in particular RC buildings, have been designed to withstand mainly gravity loads. In this context, the seismic assessment is very important to define the best retrofitting solution in order to upgrade the performance level of existing structures in line with modern codes and safety requirements [ 3 ] within the performance-based seismic design [ 4 , 5 ]. In order to improve the response to seismic actions of existing RC buildings, over the years, the isolation system with friction pendulum (FP) devices have turned out to be one of the most efficient solutions [ 6 ]. Contextually, in the literature and in practice alternative strategies and philosophies aimed to improve the seismic response of buildings, in general, are proposed and discussed [ 7 , 8 , 9 , 10 ]. With particular reference to RC-framed buildings, the main advantages of the use of FPS devices relate to the achievement of a value of the isolation period which does not depend from the mass of the superstructure, to the post-event self-recentering response and to the energy dissipation capacity [ 11 , 12 ]. In the literature, several studies have been devoted to the proper modelling of the FP bearing response investigating also the influence of main parameters able to describe their behaviour [ 13 ]. The evaluation of structural reliability of structural systems equipped with base isolation solution has been widely investigated [ 14 ] also considering random seismic excitations [ 15 ]. Similarly, referring both to 3D RC structures and to equivalent models, deterministic [ 16 ] and seismic reliability [ 17 , 18 , 19 ] analyses have been carried out. Specifically, in [ 17 , 18 , 19 ] the seismic reliability-based design (SRBD) approach has been proposed as a strategy to define some important design parameters for base-isolated systems. The aim of this work is to investigate the influence of the retrofitting intervention composed of single-concave friction pendulum devices on the seismic response on an existing reinforced concrete building located in central Italy, which is widely recognized as an area characterized by a very high seismicity. After the characterization of the geometrical features and material properties according to the “knowledge levels” approach [ 2 ], a non-linear numerical model of the structure has been defined using a fiber-approach. Then non-linear dynamic analyses have been carried out considering multiple recorded ground motions with the three accelerometric components, scaled to the design seismic intensity [ 2 ], to assess the seismic response of the building with and without the retrofitting intervention composed of the FP isolators. The results from the non-linear dynamic analysis have been useful to evaluate the effectiveness of the retrofitting technique in probabilistic terms adopting a log-normal probabilistic model for the output variables expressed as both the interstory drift index and horizontal relative displacement of the FP devices. Finally, the probabilities of exceedance of the different values of the output variables are evaluated. 2. Behavior of Single-Concave Friction Pendulum Bearings Friction pendulum (FP) devices have been widely adopted to retrofit existing buildings in areas characterized by a high seismicity [ 1 , 16 , 17 ]. Specifically, the FP devices are able to realize a disconnection between the superstructure and the foundations of the building and to absorb the major part of the displacement demand with reference to seismic response of the global structural system. Moreover, the FP devices allow a significant level of energy dissipation by means of a frictional mechanism which develops on the concave sliding surfaces [ 12 , 18 , 19 , 20 ]. With particular reference to single-concave FP bearings, these are devices able to support vertical actions and transfer horizontal actions by means of an articulated slider which slides on a concave surface having curvature radius R and radius in plan r [ 17 ]. One of the main advantages associated to the use of single-concave FP bearings is that the fundamental period of the base-isolated structural system T is depends only on the radius of curvature of the concave sliding surface R , according to the following expression: T i s = 2 π R / g (1) where g is the gravity acceleration. In line with the assumption of small angles between the vertical and the normal direction of the concave sliding surface of the single-concave FP devices, the bearing restoring force f b ( t ) expressed as a function of time t applies [ 12 ]: f b ( t ) = W R u b ( t ) + μ d ( t ) W sgn ( d u b ( t ) d t ) (2) where W = Mg denotes the total vertical load on the bearing, M is the mass on the bearing; u b ( t ) denotes the horizontal projection of the displacement of the pivot point of the slider with respect to the ground; μ d ( t ) represents the sliding dynamic friction coefficient; sgn ( du b ( t )/ dt ) denotes the sign function of the sliding velocity du b ( t )/ dt . The response of the FP device can be reproduced by means of a non-linear hysteretic model according to [ 21 ] and in line with Figure 1 . The hysteretic model representing the FP behavior can be characterized by the following three parameters: the characteristic strength Q d = μ d W ; the post-elastic stiffness denoted as K 2 = W / R ; the elastic stiffness K 1 that can be set as 51 times larger than the post-elastic stiffness K 2 according to [ 21 ]. Figure 1. Non-linear hysteretic response of the single-concave friction pendulum device. On the basis of the experimental investigations of [ 22 , 23 ], the non-linear dependence of the dynamic friction coefficient μ d ( t ) on the sliding velocity du b ( t )/ dt can be expressed using the following expression: μ d ( t ) = μ f a s t − ( μ f a s t − μ s l o w ) exp ( − α | d u b ( t ) d t | ) (3) where μ fast and μ slow are the friction coefficient at high and nearly-zero sliding velocity du b ( t )/ dt , respectively; α is a constant that regulates the rate of change of the friction coefficient μ d ( t ) with velocity in the transition from its maximum and minimum values. The model so far described is adopted in order to reproduce the response of the single-concave FP bearings when used to retrofit the existing RC building herein investigated. Representative values for the dynamic friction coefficient may be found in the technical reports from manufacturers (e.g., [ 24 ]). 3. Description of the Case Study: An Existing RC Building The case study considered for the present investigation relates to an existing framed reinforced concrete building located in central Italy in a high seismicity region (i.e., Peak Ground Acceleration—PGA higher than 0.25 g with a probability of exceedance of 10% in 50 years). According to Figure 2 , the building consists of an RC framed structure built in the 60s which is founded on inverted RC beams and have a plan dimension of 12.2 m in the transverse direction (Y) and 59.8 m in the longitudinal direction (X). Figure 2. Scheme with main dimensions of the building in plant and identification of the main RC frames in X (X1, X2) and Y (Y1, Y2, Y3) directions. Dimensions reported in [cm]. The maximum height, at the roof level, is about 16 m from the foundation level. The structure is composed of a basement, a ground-floor, two further floors and a roof floor. The ground-floor (i.e., story 1) of the structure is surrounded by a soil embankment that significantly limits its movements in X and Y horizontal directions. As in the 60s Italian design code was not conceived for seismic design, the RC building were designed without proper conception to withstand seismic actions and without the related detailing. The geometrical characteristics of the main RC frames that compose the structure are described in Figure 3 a–e with reference to the X and Y directions. Several typologies of beams and columns are present as also showed in Figure 4 . The details of the main longitudinal and shear reinforcements for the different members typologies are listed in Table 1 . The concrete cover is about 3 cm. The floors are realized with the typical Italian lightened “latero-concrete” solution with RC joist having height of 16 cm and base of 10 cm located with 50 cm of spacing with a top reinforced concrete slab of 4 cm. This structural system is able to provide a rigid floor behavior allowing a hyperstatic redistribution of horizontal actions (e.g., seismic action) between the different frames. Figure 3. Cross sections of beams and columns pertaining to the main RC frames in X and Y directions. Dimensions reported in [cm]. ( a )Frames X1. ( b ) Frame Y1. ( c ) Frame X2. ( d ) Frame Y2. ( e ) Frame Y3. Figure 4. Identification and location of the different beams and columns typologies according to Table 1 . ( a ) Stories 1-4. ( b ) Story 5 (Roof). Table 1. Details of the reinforcements for the different structural members. The mechanical characterization of the material properties, adopted in the numerical model, has been performed through appropriate destructive and “in situ” non-destructive tests. According to the prescriptions of the Italian code for structural design and assessment [ 2 ], the achieved knowledge level (KL) is the KL3, which leads to the adoption of a confidence factor C F = 1 . For instance, the material properties will be adopted with their mean values as a result of the statistical analysis of the data deriving from the tests. The mean value of concrete compressive strength has been deduced from the crushing tests of cores drilled in different locations and structural members of the structure and its value turns out to be equal to f cm = 25.2 MPa. On some specimens, strain measurements have been carried out in order to estimate the mean value of secant modulus of elasticity that is equal to E cm = 22,000 MPa. In addition, the characterization of the mechanical properties of steel used for reinforcement bars (FeB38k) has been performed using the data available from tensile tests on samples taken from different structural members. The following mean value for yield strength has been obtained: f ym = 374 MPa. The geometry of the structure with the related reinforcement arrangement and material properties has been adopted to define an appropriate non-linear numerical models using the software code SAP2000 [ 25 ]. 4. Numerical Simulation of Seismic Response of the RC Building with and without Retrofitting Using Single-Concave FPS In the present section the results from numerical non-linear dynamic analyses of the RC structure under investigation are described together with the modelling hypotheses [ 26 , 27 ] adopted to define the non-linear numerical (NLN) model and the assumptions to select the seismic inputs. In particular, SAP2000 [ 25 ] software platform has been used to realize the appropriate NLN models of the fixed-base (FB) and base-isolated (BI) structure and to perform non-linear dynamic analyses that are useful to evaluate in probabilistic terms the performance of the retrofitting intervention. 4.1. Definition of the Non-Linear Numerical Models for Fixed-Base/Base-Isolated RC Structure The numerical model of the RC structure has been realized according to the geometric features described in the previous section. In particular, the columns have been assumed as fully restrained by the stiff inverted beams at the foundation level and the behavior of rigid floors has been accounted for by means of in-plane diaphragm constrains [ 25 ]. The interaction in the non-linear dynamic simulations between the structure of the ground-floor and the surrounding soil embankment has been accounted for by means of appropriate restraints to limit the horizontal displacements in X and Y directions. In this way, the seismic response only of the ground-floor of the structure (i.e., story 1 of Figure 3 ) is restrained due to the presence of the surrounding soil embankment as will be achieved in the following. The cross-sections of the structural members (i.e., beams and columns) have been realized according to the fiber approach [ 25 ], as also developed in [ 28 ]. In particular, the mechanical properties of the fibers in each cross-section have been defined differentiating between concrete cover, core and longitudinal reinforcements. The concrete behavior in both cover and core fibers has been reproduced by means of Mander et al. [ 29 ] constitutive relationships accounting for non-linear response in compression and elastic with linear softening response in tension. The properties of concrete cover fibers (i.e., tensile strength, ultimate deformation in compression) have been derived from both the mean value of cylinder compressive strength f cm and Young’s modulus E cm according to [ 30 ]. The response of concrete core fibers has been defined evaluating the enhanced properties due to the confinement effects of the stirrups evaluated adopting the model of [ 31 ]. The properties of the reinforcement have been defined by means of an elastic-plastic law with a limited ultimate strain to reproduce both tensile ad compressive response. The yielding strength has been set equal to the mean value f ym estimated from the tests with a Young’s modulus assumed equal to 200,000 MPa and an ultimate strain set to 7.5%. The mechanical non-linearities have been included in the numerical model adopting a distributed plasticity approach (the so-called “Fiber Hinge”) implemented in the software platform SAP2000 [ 25 ]. The fiber-plastic hinges so far defined are able to account for the interaction between axial load and bending moments in X and Y directions. The moment-curvature law of the fiber-hinge law is determined on the basis of the fiber cross-section properties previously introduced. The mechanical non-linearity is developed in each fiber of the cross-section, but is not extended to the whole element [ 32 ], but are included in a portion of the RC member with a predefined length (i.e., plastic hinge length). In particular, the plastic hinge length L p is evaluated according to a well-validated formulation by Priestley et al. [ 33 ] formulation: L p = 0.08 ⋅ l + 0.022 ⋅ f y m ⋅ d ’ (4) where l is the length of the member, f ym is the mean yield strength of steel reinforcement from tests and d’ is the diameter of the smallest longitudinal reinforcing bar adopted within the cross-section. The geometric non-linearity (i.e., P-Δ effect) has been accounted for within the numerical simulations with the evaluation of the equilibrium equations with reference to the deformed structural configuration. The fundamental vibration period of the fixed-base structures is 0.80 s from the eigenvalue analysis without considering any stiffness reduction in the RC beams and RC columns. This assumption is aimed not to underestimate the effects in terms of both accelerations and seismic forces to the structure. The retrofitting using the single-concave friction pendulum (FP) has been simulated introducing a disconnection between superstructure and substructure at the top of the columns of the groundfloor. In practice, the intervention may be realized by means of the removal of the load on the columns through the use of hydraulic jacks that react on a pair of clamps fixed to each column to transfer the load by friction. Then, a portion of the column is cut at the isolation level where the friction-pendulum device should be located. This procedure, which is apparently very laborious, is not significantly demanding in practice and it is not invasive. In addition, the columns of the substructure at the isolation level may be connected through beams to improve the safety and robustness [ 3 ]. The single-concave friction pendulum (FP) isolators have been modeled using the non-linear link “Friction Pendulum” implemented in SAP2000 [ 25 ]. The latter permits one to consider compressive behavior along the vertical direction only, whereas, is able to couple the frictional properties in the X, Y directions in plan. The model reproduces the shear behavior in line with [ 34 ] and is adapted for seismic isolator bearings [ 35 ] according to the bi-linear relationships described by [ 21 ]. The parameters that have been considered to design the retrofitting intervention ware: the radius of curvature R , the stiffness values K 1 and K 2 , and the friction coefficient μ d along the two horizontal degrees of freedom (DOFs). Regarding the vertical DOF of the isolators, a linear behavior only in compression is adopted. The choice of the radius of curvature is related the isolation period of the structure [Equation (1)]. As also introduced in Section 2 , the hysteretic behavior of FPS is represented by two stiffness values: the post-elastic one K 2 that has been calculated according to the axial load on the device and the elastic stiffness K 1 that has been assumed according to [ 21 ]. The software platform SAP 2000 [ 25 ] implements Equation (3) [ 22 ] for the variation of sliding friction coefficient μ d as a function of the sliding velocity and time. An indicative value for the sliding friction coefficient has been evaluated considering an empiric relation [ 22 ] between μ d and the ratio N Sd / N Ed , where N Sd is the axial load acting on the FP device in the seismic combination of actions [ 2 , 36 ] and N Ed represents the maximum axial load for the adopted bearing device as provided by the producer. The parameters herein assumed to reproduce the FP isolator behavior are the following: R = 1.5 m, μ slow = 1%, μ fats = 3%, α = 30 s/m. In this way, the isolated period is equal to 2.66 s. The stiffness of the devices has been calculated according to the vertical load acting on the isolators. The properties of the FP devices have been determined depending on the level of the axial load on the isolator within the code seismic combination [ 2 ]. In detail, the main seismic component along the X direction combined with the lower seismic component along the Y direction and vice versa have been considered. In addition, both the main and the lower components have been assumed characterized by an eccentricity in line with [ 2 ]. The worst results have been achieved considering the eccentricity in the seismic actions. In Table 2 and in Figure 5 the main properties of the FP devices and their planimetric location are reported. The NLN numerical models of the FB and BI structure are reported in Figure 6 . Figure 5. Location of the adopted FP devices in plan. Figure 6. Non-linear numerical models for FB ( a ) and BI ( b ) structure using SAP 2000 [ 25 ]. Table 2. Types of FP devices and related characteristics. 4.2. Evaluation of the Seismic Demand and Non-Linear Dynamic Analyses The evaluation of the seismic demand in terms of elastic pseudo-acceleration S a is performed considering the elastic design response spectrum related to 50 years reference period associated to nearly-collapse limit state according to [ 2 ] with reference to the seismic hazard site. The elastic response spectra have been defined adopting two different damping ratios as shown in Figure 7 , in particular: ξ = 5% for the fixed-base (FB) NLN model and ξ = 2% as suggested by [ 17 ] for the base-isolated (BI) NLN model [ 17 ]. In general, the value of ξ = 5% is widely accepted for the dynamic analysis of FB RC structures [ 17 ]. With reference to the BI structure, the value of ξ is lower than the one related to the FB structure as the superstructure moves on the isolation level similarly to a rigid body. For instance, most of the energy in the BI structure is dissipated by hysteretic damping which is provided by the isolator devices. A value of ξ = 2% for BI RC structures is recognized according to common practice and literature references [ 3 , 17 ]. Figure 7. Elastic design response spectra according to nearly-collapse limit state [ 2 ] with two different damping ratios. The seismic inputs adopted to perform the non-linear dynamic analyses are represented by 21 recorded accelerograms [ 17 ] (each of them includes 3 accelerometric recordings in the respective directions) selected from European Strong Motion Database (ESM) [ 37 ] ( Table 3 ) and then scaled in all directions. The selection has been carried out with the aim to define a set composed of ground motions with different characteristics to represent both a record-to-record variability and event-to-event variability, as commented in [ 3 , 17 ]. The scaling factor has been defined in X direction with respect to the Intensity Measure ( IM ) related the elastic response spectrum in correspondence of the fundamental period of vibration T 1 associated to 1st eigenmode for both FB and BI structures. This is in order to ensure the compatibility of the selected ground motion inputs with elastic design response spectra defined by the design code [ 2 ] for nearly-collapse limit state. Note that the scaling factor has been defined along the direction (i.e., X direction) able to cause the worst effects. The scaled response spectra associated to the 21 recorded accelerograms are reported in Figure 8 with reference to both the FB and BI structures. Figure 8. Scaled acceleration spectra for FB ( a , b ) and BI ( c , d ) structure of the 21 real ground motion records in X direction ( a , c ); Y direction ( b , d ). Table 3. Selected ground motion records from European Strong Motion Database [ 37 ]: D denotes the epicentral distance of the event in and M the related magnitude. The non-linear dynamic analyses have been performed adopting the direct integration of the motion equations [ 38 , 39 ] which regulate the dynamic behavior of the structure with its non-linearities: [ M ] { d 2 u ( t ) d t 2 } + [ C ] { d u ( t ) d t } + [ K ] { u ( t ) } = { F ( t ) } (5) in which { d 2 u ( t )/ dt 2 } , { du ( t )/ dt} , { u ( t ) } are respectively the acceleration, velocity and displacement vector, having considered a multi-degree freedom (MDOF) system. While, [M], [C], [K] are the mass, proportional Rayleigh damping and stiffness matrix evaluated according to [ 3 , 17 ]. Finally, { F ( t ) } is the vector of external forces. In Figure 9 the hysteretic loops of one of the FP bearing subjected to the scaled motion of the earthquake EQ5 is depicted showing how different phenomena occur during the non-linear hysteretic response of the FPS device. In detail, it is possible to observe the influence of the velocity-dependent behavior of the FPS device because when the displacement is peak the sliding friction coefficient gradually decreases from μ fast to μ slow . In addition, the floating shape of the curves is due to the vertical component of each ground motion. Figure 9. Hysteresis loops of the FP bearing under the motion of the EQ5 after scaling process. The force in the hysteresis loops f b has been evaluated according to Equation (3). The effectiveness of the seismic isolation retrofitting can be appreciated by the comparison between the base shear V b from the FB numerical model to the one of the BI numerical model ( Figure 10 ). Note that the base shear assessment for the FB numerical model derives from the restoring forces, whereas for the BI numerical model derives from the inertia forces. Figure 10. Base shear comparison along the two directions: FB model ( a ), BI model ( b ). The maximum values of the base shear are concentrated in the time interval in which there are the peak values of the accelerations. The dominant values of the base shear for both models are recognised in the transverse direction Y, namely V b,y , due to the higher stiffness of the structure. The results highlight that the retrofitting intervention may avoid brittle shear failures with reference to frames characterized by high stiffness if compared to the others. Furthermore, Figure 10 a highlights a small residual plastic deformation of the column of the FB model along Y direction. The shear verifications of each structural member has been performed according to [ 30 ] in order to confirm that shear failure does not occur during the non-linear dynamic analyses for the BI structure. Starting from these values, the results of the time history analyses in terms of average interstory displacements d r have been determined for each floor of the structure and for both X and Y directions. By this way, the interstory drift index I D I have been calculated as: I D I = d r / h (6) where h is the interstory height. In Figure 11 the IDI s are plotted as a function of the elevation of the building for both the FB and BI models along both X and Y directions. In transverse Y direction the IDI s are smaller than in longitudinal X one because of the differences of the stiffness of the frames in Y and X directions. Figure 11. Comparison between the IDIs. The interstory drifts associated to both the ground-floor of the FB structure and to the sub-structure of the BI structure are zero because of the restraints which simulate the ground-structure interaction due to the presence of the soil embankment around the structure as explained in Section 4.1 . In fact, the seismic response of the story 1 ( Figure 3 ) is restrained due to the presence of the surrounding soil embankment and to the diaphragm constrains. It can be recognized the drift reduction from FB model to BI model, due to the effectiveness of FP isolators adopted for the retrofitting intervention. 5. Probabilistic Interpretation of the Results The results from the non-linear dynamic analyses in terms of interstory drift index IDI and horizontal relative displacement for the FP devices d FPS have been useful to perform the probabilistic evaluation of the performance of both FB structure and BI structure. The mentioned above parameters have been probabilistically modeled using a lognormal distribution [ 17 ], whose statistical parameters (mean value μ and standard deviation σ ) are estimated from the numerical results of non-linear dynamic analyses through the maximum likelihood method [ 40 , 41 ]. The hypothesis of lognormal probabilistic model has been validated trough Chi-square statistical test with level of significance 5%. The monovariate probability density functions (PDFs) have been computed according to: f ( I D I ) = 1 I D I σ ln ( I D I ) 2 π exp [ − 1 2 ( ln ( I D I ) − μ ln ( I D I ) σ ln ( I D I ) ) 2 ] (7) f ( d F P S ) = 1 d F P S σ ln ( d F P S ) 2 π exp [ − 1 2 ( ln ( d F P S ) − μ ln ( d F P S ) σ ln ( d F P S ) ) 2 ] (8) The probability of exceedance P f of a given limit state ( LS ) has been calculated as follows: P f = P ( I D I > I D I L S ) = 1 − P ( I D I ≤ I D I L S ) (9) where the probability P ( IDI≤IDI LS ) can be directly estimated by the lognormal cumulative density functions (CDFs). Figure 12 a,b report the monovariate lognormal distributions (PDFs) associated to the IDIs of the different stories with reference to both the FB and BI structure, while Figure 13 a,b report the related CDFs with the indication of a generic limit state threshold for evaluation of the associated probability of exceedance P f . Figure 12. Lognormal monovariate PDFs for the IDIs in X and Y direction: FB model ( a ), BI model ( b ). Figure 13. Lognormal monovariate CDFs for the IDIs in X and Y direction: FB model ( a ), BI model ( b ). Concerning the BI structure, Figure 14 a,b illustrate the monovariate lognormal distributions (PDFs) and the cumulative density functions (CDFs) related to the d FPS in both the X and Y directions. It can be recognized that the retrofitting intervention is able to reduce the probability of exceedance of pre-determined limit state threshold. Because the structure turns out to be stiffer in the Y direction, both IDIs and d FPS in that direction are significantly smaller if compared to the values in the X direction. Figure 14. Lognormal monovariate PDFs and CDFs for horizontal relative displacement of FP device in X and Y direction with reference to the isolation level. ( a ) PDFs. ( b ) CDFs. Adopting the probabilistic distributions so far described, it is possible to estimate the probability of exceedance P f for different values of IDIs and d FPS . The results in terms of probability of exceedance P f are reported in Figure 15 a–c with reference to the different stories for the FB and BI structure and for the isolation level. The retrofitting intervention allows to reduce significantly the demand in terms of interstory drift leading to probability of exceedance P f lower than 1 order of magnitude with respect to the FB structure for specific values of the IDIs. This aspect is fundamental for the safety [ 42 ] of the structural systems. Figure 15. Exceeding monovariate probabilities (logarithmic scale): FB model ( a ); BI model ( b ); Isolation level for BI model ( c ). The descending trend of the exceeding probabilities plotted in Figure 15 is perfectly in line with the results described in [ 3 , 17 ]. In fact, higher values of the limit state thresholds are associated to lower and lower values of P f in relation to both superstructure and isolation level. The analysis puts in evidence the importance to assess the seismic performance in probabilistic terms for each story and along the both directions for the both models (i.e., FB structure and BI structure). In fact, the results highlight the structural weakness along the X direction and higher values of the exceeding probabilities for lower floors due to also the vertical components of the records. These exceeding probabilities are strongly reduced in the configuration retrofitted through FPS showing a strong plastic reduction of the structural members [ 18 ]. As for the isolation level, the results demonstrate that also for the FPS devices the responses along the two orthogonal directions are different. Specifically, along the Y direction the seismic demand is higher due to more effective behavior of the seismic device able to reduce the seismic demand to the superstructure. In addition, the results confirm the effectiveness of the beams connecting the columns at the substructure ( Section 4.1 ) able to improve the safety and robustness of the system as proposed in [ 3 ]. 6. Conclusions The present investigation aimed to evaluate the influence of the seismic retrofitting of an existing RC building using single-concave friction pendulum devices in probabilistic terms. First of all, an existing RC building has been characterized from a geometrical point of view and the related material properties have been assessed by means of the results from destructive and non-destructive tests. Then, non-linear numerical models of the structure have been defined using fiber cross-sections approach for the fixed base (FB) structure and the base isolated (BI) system including proper modelling of the response of the FP bearings under seismic actions. Non-linear dynamic analyses have been carried out accounting 21 recorded seismic events with the three components. The records have been scaled to the value of the pseudo-acceleration of the design elastic spectrum for nearly-collapse limit state associated to 50 years reference life in correspondence of the fundamental periods of both the FB and BI structures. The results of the non-linear dynamic analyses highlight the effectiveness of the retrofitting intervention in the reduction of the value of the base shear. In particular, as in existing RC buildings the amount of shear reinforcements is almost lower than minimum values required by current design codes, the latter results can avoid the occurrence of brittle shear failure in columns pertaining to stiffer RC frames. Next, the probabilistic interpretation of the results in terms of interstory drift index and displacement at the level of the isolation devices has been carried out adopting a lognormal probabilistic model. The probabilities of exceedance associated to different values of the mentioned above parameters have been evaluated highlighting a reduction of more than 1 order of magnitude between the FB structure and the structure retrofitted by means of single-concave FP devices. This aspect is fundamental for the safety of the structure. Author Contributions Conceptualization, P.C.; Data curation, D.G., C.A., M.F. and G.B.; Formal analysis, D.G., C.A., M.F., G.B. and L.G.; Investigation, D.G., C.A., M.F. and P.C.; Methodology, D.G., P.C., G.B. and L.G.; Project administration, P.C.; Supervision, P.C. and L.G.; Validation, L.G.; Visualization, C.A., G.B. and L.G.; Writing—original draft, D.G. and P.C. All authors have read and agreed to the published version of the manuscript. Funding This research received no external funding. Acknowledgments This work is a part of the collaborative activity developed by the authors within the framework of the Line 6—WP 2—Task 2.1—ReLUIS 2017. Conflicts of Interest The authors declare no conflict of interest. References Gino, D.; Castaldo, P.; Bertagnoli, G.; Giordano, L.; Mancini, G. Partial Factor Bulletin 80: Assessment of an Existing Prestressed Concrete Bridge. Struct. Concr. 2020 , 21 , 15–31. [ Google Scholar ] [ CrossRef ] NTC18. 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[ Google Scholar ] [ CrossRef ][ Green Version ] Figure 1. Non-linear hysteretic response of the single-concave friction pendulum device. Figure 2. Scheme with main dimensions of the building in plant and identification of the main RC frames in X (X1, X2) and Y (Y1, Y2, Y3) directions. Dimensions reported in [cm]. Figure 3. Cross sections of beams and columns pertaining to the main RC frames in X and Y directions. Dimensions reported in [cm]. ( a )Frames X1. ( b ) Frame Y1. ( c ) Frame X2. ( d ) Frame Y2. ( e ) Frame Y3. Figure 4. Identification and location of the different beams and columns typologies according to Table 1 . ( a ) Stories 1-4. ( b ) Story 5 (Roof). Figure 5. Location of the adopted FP devices in plan. Figure 6. Non-linear numerical models for FB ( a ) and BI ( b ) structure using SAP 2000 [ 25 ]. Figure 7. Elastic design response spectra according to nearly-collapse limit state [ 2 ] with two different damping ratios. Figure 8. Scaled acceleration spectra for FB ( a , b ) and BI ( c , d ) structure of the 21 real ground motion records in X direction ( a , c ); Y direction ( b , d ). Figure 9. Hysteresis loops of the FP bearing under the motion of the EQ5 after scaling process. Figure 10. Base shear comparison along the two directions: FB model ( a ), BI model ( b ). Figure 11. Comparison between the IDIs. Figure 12. Lognormal monovariate PDFs for the IDIs in X and Y direction: FB model ( a ), BI model ( b ). Figure 13. Lognormal monovariate CDFs for the IDIs in X and Y direction: FB model ( a ), BI model ( b ). Figure 14. Lognormal monovariate PDFs and CDFs for horizontal relative displacement of FP device in X and Y direction with reference to the isolation level. ( a ) PDFs. ( b ) CDFs. Figure 15. Exceeding monovariate probabilities (logarithmic scale): FB model ( a ); BI model ( b ); Isolation level for BI model ( c ). Table 1. Details of the reinforcements for the different structural members. Structural Member Longitudinal Reinforcement Shear Reinforcement Longitudinal Reinforcement Shear Reinforcement Story 1 2 Column type 1 2𝜙20 + 5𝜙16/2𝜙20 + 5𝜙16 𝜙6/8 mm (2 leg stirrups) 2𝜙20 + 5𝜙16/2𝜙20 + 5𝜙16 𝜙6/8 mm (2 leg stirrups) Column type 2 Column type 3 2𝜙20 + 5𝜙14/2𝜙20 + 5𝜙14 𝜙6/12 mm (2 leg stirrups) 2𝜙20 + 5𝜙14/2𝜙20 + 5𝜙14 𝜙6/12 mm (2 leg stirrups) Beam type 1 Midspan: Top 2𝜙14 Bottom 5𝜙16 𝜙6/19 mm (2 leg stirrups) Midspan: Top 2𝜙14 Bottom 5𝜙16 𝜙6/19 mm (2 legs stirrups) Support: Top 2𝜙14 + 5𝜙20 Bottom 2𝜙16 𝜙6/10 mm (2 leg stirrups) Support: Top 2𝜙14 + 5𝜙20 Bottom 2𝜙16 𝜙6/10 mm (2 leg stirrups) Beam type 2 Midspan Top 2𝜙12 Bottom 5𝜙14 𝜙6/19 mm (2 leg stirrups) Midspan Top 2𝜙12 Bottom 5𝜙14 𝜙6/19 mm (2 leg stirrups) Support Top 2𝜙14 + 5𝜙20 Bottom 3𝜙16 𝜙6/10 mm (2 leg stirrups) Support Top 2𝜙14 + 5𝜙20 Bottom 3𝜙16 𝜙6/10 mm (2 leg stirrups) Beam type 3 Top 2𝜙10 + 2𝜙12 Bottom 2𝜙10 + 2𝜙12 𝜙6/30 mm (2 leg stirrups) Top 4𝜙10 Bottom 2𝜙10 + 2𝜙12 𝜙6/30 mm (2 leg stirrups) Beam type 4 Top 4𝜙10 Bottom 4𝜙10 𝜙6/30 mm (2 leg stirrups) Top 4𝜙10 Bottom 4𝜙10 𝜙6/30 mm (2 leg stirrups) Beam type 5 Top 4𝜙14 Bottom 4𝜙14 𝜙6/10 mm (2 leg stirrups) Top 4𝜙14 Bottom 4𝜙14 𝜙6/10 mm (2 leg stirrups) Story 3 4 Column type 1 2𝜙20 + 5𝜙14/2𝜙20 + 5𝜙14 𝜙6/10 mm (2 leg stirrups) 2𝜙20 + 5𝜙14/2𝜙20 + 5𝜙14 𝜙6/12 mm (2 leg stirrups) Column type 2 Column type 3 𝜙6/12 mm (2 leg stirrups) Beam type 1 Midspan: Top 2𝜙14 Bottom 5𝜙16 𝜙6/19 mm (2 leg stirrups) Midspan: Top 2𝜙14 Bottom 5𝜙16 𝜙6/19 mm (2 leg stirrups) Support: Top 2𝜙14 + 5𝜙20 Bottom 2𝜙16 𝜙6/10 mm (2 legs stirrups) Support: Top 2𝜙14 + 5𝜙20 Bottom 2𝜙16 𝜙6/10 mm (2 legs stirrups) Beam type 2 Midspan Top 2𝜙12 Bottom 5𝜙14 𝜙6/19 mm (2 legs stirrups) Midspan Top 2𝜙12 Bottom 5𝜙14 𝜙6/19 mm (2 legs stirrups) Support Top 2𝜙14 + 5𝜙20 Bottom 3𝜙16 𝜙6/10 mm (2 legs stirrups) Support Top 2𝜙14 + 5𝜙20 Bottom 3𝜙16 𝜙6/10 mm (2 legs stirrups) Beam type 3 Top 3𝜙10 Bottom 2𝜙10 + 1𝜙12 𝜙6/30 mm (2 legs stirrups) Top 4𝜙10 + 2𝜙12 Bottom 2𝜙10 𝜙6/30 mm (2 legs stirrups) Beam type 4 Top 4𝜙10 Bottom 4𝜙10 𝜙6/30 mm (2 legs stirrups) Top 4𝜙10 Bottom 4𝜙10 𝜙6/30 mm (2 legs stirrups) Beam type 5 Top 4𝜙14 Bottom 4𝜙14 𝜙6/10 mm (2 legs stirrups) Top 4𝜙10 + 1𝜙12 Bottom 2𝜙10 + 1𝜙12 𝜙6/10 mm (2 legs stirrups) Story 5 ( Roof ) Beam type 6 Top 2𝜙16 + 5𝜙20 Bottom 3𝜙16 + 2𝜙14 𝜙6/10 mm (2 legs stirrups) Beam type 7 Top 4𝜙10 Bottom 2𝜙12 + 2𝜙10 𝜙6/10 mm (2 legs stirrups) Table 2. Types of FP devices and related characteristics. FPS Type 1 Type 2 Type 3 Type 4 Type 5 Type 6 Type 7 Type 8 Type 9 R [m] 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 K 2 [kN/m] 355 442 471 293 413 400 431 335 382 K 1 [kN/m] 18,080 22,517 23,996 14,957 21,038 20,381 21,958 17,093 19,460 Table 3. Selected ground motion records from European Strong Motion Database [ 37 ]: D denotes the epicentral distance of the event in and M the related magnitude. Earthquake Event Date M [-] Fault Mechanism D [km] EQ1—Bingol 05/01/2003 6.3 Strike-slip 11.79 EQ2—Christchurch 06/13/2011 6 Reverse 5.1 EQ3—Darfield 09/03/2010 7.1 Strike-slip 13.31 EQ4—E Off Izu Peninsula 05/03/1998 5.5 Reverse 9.5 EQ5—EMILIA_Pianura_Padana 05/29/2012 6 Reverse 4.73 EQ6—Friuli 4th shock 09/15/1976 5.9 Reverse 16.83 EQ7—Hector Mine 10/16/1999 7.1 Strike-slip 28.61 EQ8—Honshu 08/10/1996 5.9 Reverse 13.89 EQ9—Hyogo-Ken Nanbu 01/16/1995 6.9 Strike-slip 16.6 EQ10—Landers 06/28/1992 7.3 Strike-slip 13.08 EQ11—L’Aquila mainshock 04/06/2009 6.3 Normal 5.65 EQ12—Loma Prieta 10/18/1989 6.9 Oblique 27.59 EQ13—Mid Niigata Prefecture 10/23/2004 6.6 Reverse 16.42 EQ14—Mt. Fuji Region 03/15/2011 5.9 Strike-slip 12.8 EQ15—N. Miyagi Prefecture 07/25/2003 6.1 Reverse 9.93 EQ16—Northridge 01/17/1994 6.7 Reverse 20.19 EQ17—Off Noto Peninsula 03/25/2007 6.7 Reverse 6.64 EQ18—Olfus 05/29/2008 6.3 Strike-slip 8.25 EQ19—South Iceland 06/17/2000 6.5 Strike-slip 5.25 EQ20—Southern Iwate Prefecture 06/13/2008 6.9 Reverse 23.08 EQ21—W. Tottori Prefecture 10/06/2000 6.6 Strike-slip 11.78 Gino, Diego, Costanza Anerdi, Paolo Castaldo, Mario Ferrara, Gabriele Bertagnoli, and Luca Giordano. 2020. "Seismic Upgrading of Existing Reinforced Concrete Buildings Using Friction Pendulum Devices: A Probabilistic Evaluation" Applied Sciences10, no. 24: 8980. https://doi.org/10.3390/app10248980 Article Metrics
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Sustainability | Free Full-Text | Efficient Recovery of V, W, and Regeneration of TiO2 Photocatalysts from Waste-SCR Catalysts Discarded Waste-SCR (selective catalytic reduction) catalysts not only harm the natural environment, but also hinder the recovery of valuable metals such as V, W, and Ti, thus resulting in a waste of resources. Therefore, it has become imperative to dispose of Waste-SCR catalysts in large amounts. This study aims to develop a complete, eco-friendly, and economical process of dealing with Waste-SCR catalysts. In this process, the recovery of V and W from Waste-SCR catalysts was achieved in several steps. In addition, the leaching conditions of the acid-base process were optimized, while the structure and composition of the leaching residual were studied in depth. Sodium titanates generated by alkali leaching were then applied for regeneration of the TiO2 photocatalyst. It is worth noting that Fe-doped TiO2 photocatalysts were also prepared, while the required iron source was obtained through acid leaching. Regenerated photocatalyst achieved an excellent performance in the photocatalytic degradation of dye pollutants, which is attributable to small particle size and low forbidden band width. This contributes a new idea to the recycling of solid waste, and the economical treatment of wastewater. Efficient Recovery of V, W, and Regeneration of TiO 2 Photocatalysts from Waste-SCR Catalysts by Ken Cheng 1 , Yi Yu 1 , Bolun Mei 1 , Yang Li 2,* and Li Xu 1,* School of Chemical Engineering, Zhengzhou University, Zhengzhou 450000, China Jiangsu Longking—Cotech Environmental Protection Technology Co., Ltd., Yancheng 224000, China Sustainability 2022 , 14 (16), 10284; https://doi.org/10.3390/su141610284 Received: 27 July 2022 / Revised: 10 August 2022 / Accepted: 12 August 2022 / Published: 18 August 2022 Abstract : Discarded Waste-SCR (selective catalytic reduction) catalysts not only harm the natural environment, but also hinder the recovery of valuable metals such as V, W, and Ti, thus resulting in a waste of resources. Therefore, it has become imperative to dispose of Waste-SCR catalysts in large amounts. This study aims to develop a complete, eco-friendly, and economical process of dealing with Waste-SCR catalysts. In this process, the recovery of V and W from Waste-SCR catalysts was achieved in several steps. In addition, the leaching conditions of the acid-base process were optimized, while the structure and composition of the leaching residual were studied in depth. Sodium titanates generated by alkali leaching were then applied for regeneration of the TiO 2 photocatalyst. It is worth noting that Fe-doped TiO 2 photocatalysts were also prepared, while the required iron source was obtained through acid leaching. Regenerated photocatalyst achieved an excellent performance in the photocatalytic degradation of dye pollutants, which is attributable to small particle size and low forbidden band width. This contributes a new idea to the recycling of solid waste, and the economical treatment of wastewater. Keywords: Waste-SCR catalysts ; hydrometallurgical recovery ; catalysts regeneration ; TiO 2 photocatalysts 1. Introduction 1 ], at most. In many cases, Waste-SCR catalysts are discarded even when there is no effective means to dispose of them. The discarded solid waste not only occupies a large amount of land resource, but it also hinders valuable metals such as V, W, and Ti contained in the catalysts from being effectively recycled, thus resulting in the waste of resources [ 2 ]. In recent years, study has been conducted on the recovery of Waste-SCR catalysts. In general, the recovery of Waste-SCR catalysts can be achieved through a dry process or wet process. The dry recovery process is usually reliant on the molten salt reaction of a substance with strong alkalinity (such as NaOH, Na 2 CO 3 ), the Waste-SCR catalyst converting vanadium and tungsten into soluble vanadate and tungstate, and TiO 2 generating insoluble titanate, thereby realizing the separation of V, W, and Ti [ 3 , 4 ]. Nevertheless, TiO 2 recovered using this method tends to show mixed crystals of anatase and rutile, thus resulting in low purity. In addition, the roasting temperature is high in the dry process, and energy loss is substantial. Consequently, it is difficult to recycle for commercial purposes, TiO 2 obtained through the dry process. The wet process relies on acid or alkali to leach the spent SCR catalyst, adjust the physical and chemical conditions of the solution, separate the different components, and further recycle and process them into the desired products. To date, there have been some studies conducted on the leaching of Waste-SCR with acid [ 5 , 6 ]. In particular, organic acids derived from green sources have attracted extensive attention due to their less severe secondary pollution, and higher leaching efficiency, than inorganic acids. However, acid metallurgy also shows a significant disadvantage in that the valuable metal, W, cannot be effectively leached. Therefore, wet alkaline leaching has gradually drawn the attention of people. By means of high-temperature pressurization, the leaching efficiency of V and W can exceed 90% [ 7 ]. Nevertheless, alkaline metallurgy also has its own weaknesses. The leached vanadium and tungsten are mainly recovered by using a stepwise precipitation method. Since they are both transition metals with similar properties, behaviors, and orientations in solution, the range of pH value required to precipitate V and W is also similar, which significantly increases the difficulty of V and W separation [ 8 ]. In short, it is imperative to develop an effective solution to the eco-friendly recycling of valuable metals from Waste-SCR catalysts. In addition to the recovery of valuable metals, it is also worth paying attention to the reutilization of the TiO 2 carrier, with a content of up to 80–90% in the spent SCR catalyst. TiO 2 has attracted extensive attention as a photocatalyst because of its excellent photoelectric properties, stable chemical properties, low cost, and non-toxicity [ 9 , 10 , 11 , 12 ]. However, there remain some constraints on the practical applications of TiO 2 photocatalysts. Since they are mainly produced from expensive chemical reagents, such as TiCl 4 [ 13 ], TiOSO 4 [ 14 , 15 ], and Ti(OC 4 H 9 ) 4 (TBOT) [ 16 , 17 ], the production cost is fairly high. In addition, the low-efficiency utilization of solar energy results from their wide band gap (3.2 eV for anatase and 3.0 eV for rutile). In view of the above problems, the TiO 2 derived from spent SCR catalysts was applied in this study as a secondary raw material for photocatalysts. Herein, both V and W were efficiently leached in steps through the acid-base wet process, with sustainable TiO 2 photocatalyst produced. Notably, Fe-doped photocatalyst was also obtained by doping the FeC 2 O 4 precipitated in the acid leaching process into TiO 2 for improved solar energy utilization and reduced band gap, which has been demonstrated as effective in improving photocatalyst efficiency. The optimal process conditions of phased leaching for V, W, and Ti were determined, and the leaching residues were analyzed in depth. Finally, the physical and chemical properties and photocatalytic performance of regenerated photocatalysts were examined. 2. Materials and Methods The experimental raw materials (Waste-SCR catalysts) were obtained from a thermal power plant in Jiangsu, China. To ensure the consistency of this experiment, the Waste-SCR used in the experiment was collected from the same batch. The equipment used in the experimental process mainly includes a constant temperature oil bath and high-pressure reactor. Oxalic acid leaching was carried out in a constant temperature oil bath, and NaOH leaching was performed in a high-pressure reactor. The elemental composition of the samples was analyzed by using Axios X-ray fluorescence spectrometer (XRF, panalytical company of the Netherlands, Almelo, The Netherlands), and optima 5300dv inductively coupled plasma atomic emission spectrometer (ICP-AES, Pekin Elmer company of the United States, Waltham, MA, USA). The phase structure was analyzed by using empyrean X-ray diffractometer (XRD, panalytical company of the Netherlands). Fei Talos f200s (TEM, Thermofisher, Waltham, MA, USA) was applied to conduct surface morphology analysis. To carry out the analysis of pore structure, an autosorb−1 automatic physicochemical adsorption instrument was employed (BET, quantachrome company of the United States, Boynton Beach, FL, USA). The diffuse reflectance spectra were recorded by using an ultraviolet−visible (UV−vis) spectrophotometer (DRS, PE lambda 750, Waltham, MA, USA). Fourier transform infrared spectroscopy was applied to analyze the functional groups on the surface of the sample. (FT-IR, Bruker TENSOR II, Rheinstetten, Germany). The experimental steps were as follows: First, the Waste-SCR catalysts (denoted as Waste-SCR) were pulverized and ground. Subsequently, Waste-SCR was added into the oxalic acid solution that had reached the preset temperature. After the reaction was complete, the suspension was naturally cooled to room temperature. The acid leaching solution was collected by filtration and then analyzed by ICP. The filter residue, denoted as Residue-A, was washed and dried for 12 h. The NaOH solution and oxalic acid residues were poured into a high-pressure reactor, mixed well, and sealed. After the heating program was set, stirring was performed when the preset temperature was reached. After the reaction, the reactor was cooled down to room temperature. The alkali leaching solution was collected by filtration and then analyzed by ICP. The filter residue, denoted as Residue-B, was washed and dried for 12 h. The leaching efficiency was calculated through the following equation: x = n V C × 10 − 6 m w (1) where, x represents the leaching rate of the element; n denotes the dilution ratio of the sample; V indicates the volume of the leaching filtrate; C refers to the concentration of each element tested by ICP-AES; m stands for the mass of the raw material sample added; and w denotes the mass percentage of each element in the raw material. The oxalic acid leaching solution was exposed to sufficient sunlight, and the FeC 2 O 4 precipitate was collected after one night. Of course, incident daylight was variable and intermittent. When required, the solutions were agitated by using a stirrer motor and paddle, or a hotplate stirrer and magnetic follower, before being thermostatted in a water bath. H 2 SO 4 aqueous solution was treated as the pickling agents for Residue-B. After pickling, the precipitate was centrifuged and washed until becoming neutral. After drying, it was denoted as a sample precursor. The sample precursor was divided into two parts, with one directly calcined in a muffle furnace at 400 °C, and the other thoroughly ground for at least 1 h, after mixing with the FeC 2 O 4 precipitate and then calcined. The photocatalytic abilities of the regenerated TiO 2 products were evaluated by measuring the degradation of Rhodamine B (RhB) aqueous solutions at 25 °C. A 350 W xenon lamp (BBZM-II, Langxi Bobei Lighting Electric Factory, Xuancheng, China) was used as the source of lighting. The specific experimental procedures are detailed as follows: Firstly, 0.05 g of photocatalysts were dissolved into 100 mL of dye solutions. Secondly, the solutions were continuously stirred for 30 min in the dark to reach adsorption equilibrium. Thirdly, the solutions were exposed to sunlight. Fourthly, the 4 mL of suspensions were collected by using a 5 mL pipetting gun at intervals. Fifthly, the suspensions were centrifuged at 4000 rpm for 15 min and filtered through a 0.22 μm filter. Finally, the supernatants were analyzed using a UV-Vis spectrophotometer (UV-2401PC, Zhejiang Huacong Instrument Co., Ltd., Hangzhou, China) to evaluate the photodegradability of the samples. The photocatalytic degradation rate was calculated through the following formula: η = A 0 − A A 0 × 100 % (2) where A 0 represents the initial absorbance of the degraded product; A represents the absorbance of the degraded product at the end of catalysis; η represents the degradation rate of the degraded product at the end of catalysis. 3. Results 3.1. Characterization of Waste-SCR The results of XRF analysis for Waste-SCR are shown in Table 1 . The Waste-SCR is mainly composed of the carrier TiO 2 and the active agent WO 3 , accounting for 85.49% and 4.38%, respectively. The active component V 2 O 5 accounts for 0.65%. In addition, there are small amounts of various impurity elements such as Fe, Al, Si, etc. The XRD pattern of Waste-SCR is shown in Figure 1 , from which it can be seen that the diffraction peaks of Waste-SCR are completely consistent with the diffraction peaks of anatase TiO 2 . At the same time, there are no diffraction peaks observed for V 2 O 5 , WO 3, and other impurities, which may be due to the fact that the content of components other than TiO 2 being less than 5%, and are widely distributed on the surface of the TiO 2 support. 3.2. Mechanism and Optimization of Leaching Process 3.2.1. Leaching Process Mechanism In the Waste-SCR catalyst, element V exists in the form of V 2 O 5 . Due to the strong reducibility and high coordination ability of oxalic acid, V can be involved in redox and dissolution coordination reactions with oxalic acid [ 6 , 18 ]. As shown in Equation (3), stable VO(C 2 O 4 ) 2 2− complexes are generated. However, the valence state of W and Ti elements remains unchanged in the reducing acid solution. The leaching process is confined to dissolving WO 3 and TiO 2 . A small amount of dissolved WO 3 and TiO 2 exist in acidic solutions as WO 2 2+ and TiO 2+ , respectively. In the oxalic acid system, WO 2 2+ and TiO 2+ tend to be combined with the complexing agent oxalate, thus forming complexes such as WO 2 (C 2 O 4 ) 2 2− and TiO(C 2 O 4 ) 2 2− . Equations (4) and (5) show the dissolution reaction of W and Ti. V 2 O 5 + 5H 2 C 2 O 4 = 2H 2 VO(C 2 O 4 ) 2 + 3H 2 O + 2CO 2 (3) WO 3 + 2H 2 C 2 O 4 = H 2 WO 2 (C 2 O 4 ) 2 + H 2 O (4) TiO 2 + 2H 2 C 2 O 4 = H 2 TiO(C 2 O 4 ) 2 + H 2 O (5) In the alkaline leaching process, WO3 reacts in strong alkaline solution to form soluble tungstate [ 19 ]. TiO 2 does not form soluble matter in the alkaline solution system, which reacts with NaOH to form insoluble Na 2 TiO 3 [ 20 ]. The reaction formula of W, Ti, and NaOH can be expressed as Equations (6) and (7). 2NaOH + TiO 2 = Na 2 TiO 3 + H 2 O (6) 2NaOH + WO 3 = Na 2 WO 4 + H 2 O (7) Figure 2 shows a thermodynamic analysis of Equations (1), (4) and (5). According to Figure 2 a, all the values of standard Gibbs free energy are negative, suggesting a greater spontaneous trend for the leaching of vanadium in oxalic acid solution, and the leaching of tungsten and titanium in NaOH solution. In addition, Equation (4) shows a larger absolute value of Gibbs free energy change than Equation (5), indicating that WO 3 is more likely to react with NaOH than TiO 2 . As shown in Figure 2 b, the enthalpy changes for the three leaching reactions are all negative, implying that they are all exothermic. Consequently, it is thermodynamically feasible to recover V by means of leaching with oxalic acid, and recover W and Ti by means of leaching with NaOH. 3.2.2. Optimization of the Leaching Process Figure 3 a shows the effect produced by oxalic acid concentration on Residue-A under the following conditions: a reaction time of 3 h; a reaction temperature of 60 °C; and a H 2 C 2 O 4 -Waste-SCR ratio of 10 mL/g. When H 2 C 2 O 4 concentration increased from 0.5 mol/L to 1.0 mol/L, the leaching rate rose from 61.8% to 69.3% for V, and from 4.3% to 10.4% for W. When the oxalic acid concentration exceeded 1.0 mol/L, the leaching rate of V barely changed, while that of W continued increasing slowly with the rise of oxalic acid concentration. The leaching rate of Ti was consistently below 0.5%. In order to facilitate subsequent operations and recover high-purity V, we needed to control the leaching rate of W, while ensuring the efficient leaching of V. Therefore, the optimal H 2 C 2 O 4 concentration was set to 1 mol/L. According to the XRD patterns in Figure 3 b, Residue-A shows only the diffraction peak of anatase TiO 2 at different H 2 C 2 O 4 concentrations. Figure 3 c shows the effect caused by reaction temperature on Residue-A under the following conditions: an oxalic acid concentration of 1.0 mol/L; a reaction time of 3 h; and a H 2 C 2 O 4 -Waste-SCR ratio of 10 mL/g. The leaching rate of V increased rapidly with temperature rise, from 69.3% at 60 °C to 86.8% at 100 °C. By comparison, the leaching rate of W and Ti reached their maximum at 100 °C, which is 16.0% and 0.89%, respectively. This is because the ion diffusion rate between oxalic acid and the spent catalyst increases with temperature rise, which accelerates the dissolution of the waste catalyst. Nevertheless, when the leaching temperature reached above 100 °C, the reaction solution was close to boiling. Consequently, oxalic acid volatilized in large amounts and thermal decomposition occurred [ 21 ]. Thus, 100 °C was chosen as the optimal reaction temperature. As can be seen from the XRD patterns in Figure 3 d, only anatase TiO 2 was detected at different temperatures, which evidences that the leaching of oxalic acid made no difference to the phase structure of the sample within the selected concentration and temperature ranges. Figure 4 a shows the effect of NaOH concentration on Residue-B under the following conditions: a reaction time of 3 h; a reaction temperature of 150 °C; and a NaOH -Residue-A ratio of 10 mL/g. When NaOH concentration reached 2 mol/L, the leaching of W was merely 52.6%. With the increase of alkali concentration, leaching rate increased rapidly for W. When alkali concentration reached 8 mol/L, the W leaching rate was 98.6%, which is close to 100%. At this time, the W leaching rate hardly changed, given a continued increase of alkali concentration; therefore, the optimal concentration of NaOH was set to 8 mol/L. Figure 4 b shows the XRD patterns of slag B under different NaOH concentrations. From this figure, it can be clearly seen that the diffraction peak of anatase TiO 2 is gradually weakened with the rise of concentration. Residue-B is in amorphous state at a higher concentration than 8 mol/L, which indicates that the transformation of TiO 2 into amorphous titanate is almost complete. Figure 4 c shows the effect of reaction temperature on Residue-B under the following conditions: a NaOH concentration of 8.0 mol/L; a reaction time of 3 h; and a NaOH -Residue-A ratio of 10 mL/g. As reaction temperature rose, the leaching rate of W increased rapidly. At 90 °C, the leaching rate of W reached merely 60.0%. When the temperature further increased to 150 °C, the leaching rate of W reached 99.6%. As the temperature continued its upward trend, the leaching rate of W increased, thus adding to unnecessary energy consumption and equipment burden; therefore, the optimal leaching temperature was set to 150 °C. Figure 4 d shows the XRD patterns of Residue-B at different reaction temperatures. With the increase of reaction temperature, the diffraction peak of anatase TiO 2 in Residue-B was gradually weakened, indicating a gradual decrease in the content of anatase TiO 2 crystals in slags. When the temperature reached above 150 °C, the characteristic peak of TiO 2 diffraction vanished, and amorphous titanate was generated. 3.2.3. Composition and Structure Analysis of Residues To better understand the leaching process, the residues were also analyzed before and after leaching. Table 2 shows the chemical composition of Residue-A and Residue-B. It can be seen from this table that the TiO 2 content is 89.42% and 88.28% for Residue-A and Residue-B, respectively, both of which are slightly higher compared to Waste-SCR. The content of V 2 O 5 and Fe 2 O 3 fell below 0.11% after leaching with oxalic acid, which suggests that oxalic acid exerted a significant leaching effect on both V and Fe. In addition, the content of WO 3 was merely 0.10%, and the molding aids (Al 2 O 3 , SiO 2 , CaO) were effectively removed after the leaching of sodium hydroxide, indicating that the residue was completely purified. Figure 5 shows the FT-IR spectra of different leached residues. The bands observed in the range of 796−438 cm −1 are assigned to Ti−O and Ti−O−Ti groups [ 22 ]. The absorption band at 887 cm −1 can be observed in Reside-B, which is attributed to the vibration of Ti-O-Na [ 23 ]. It is shown that NaOH reacts with the main phase TiO 2 , which destroys the Ti-O-Ti bond. In addition, the bands observed at 2923, 2852, 2347, and 1633 cm −1 can be attributed to the strong interaction between -OH groups and Ti 4+ [ 24 ]. The absorption peaks at 1122 cm −1 and 1063 cm −1 are attributed to the characteristic peaks of SO 4 2− and the stretching vibration peaks of ν(S-O), formed by the interaction of SO 4 2− species and TiO 2 surface, respectively [ 25 ]. After leaching with oxalic acid, the characteristic peaks of SO 4 2- disappeared, implying that oxalic acid is effective in removing the sulfate that blocked the pores, rather than the SO 4 2− species acting on the surface of TiO 2 . However, after leaching with sodium hydroxide, the ν(S-O) stretching vibration peak vanished, indicating that the surface structure of TiO 2 was affected by NaOH, and the surface structure was reorganized. Consequently, SO 4 2− was completely removed. Figure 6 a shows the N 2 adsorption-desorption isotherms of the slags. According to the classification of IUPAC, all slags exhibited type IV adsorption isotherms, indicating that the slags were mesopores [ 26 ]. The N 2 adsorption-desorption isotherms of Waste-SCR and H 2 C 2 O 4 residue were basically identical, with a narrow hysteresis loop shown by both. However, after alkali leaching, the hysteresis loop of the slags was elongated. NaOH residues manifested the H3 hysteresis loop of a typical flake granular material. Figure 6 b shows the BJH pore size distribution of the slags. According to this figure, the pore size of Waste-SCR and H 2 C 2 O 4 residue is concentrated in the range of 5–46 nm, which falls within the typical mesoporous range. The pore size of NaOH residue is concentrated in the range of 3–5 nm, which falls within the range of small mesopores. The pore structure parameters of different residues are listed in Table 3 . These results demonstrate that the acid leaching process will not undermine the original pore structure, and only removes part of the particles that block the pore. In contrast, in the strong alkali system, the Ti-O-Ti bonds in anatase TiO 2 collapse, and these broken Ti-O bonds can be attacked by Na + [ 27 ]. As a result, Ti-O-Na bonds are formed and the pore structure of the slag is altered. In addition, impurities in the pores are released and fully exposed to the strong alkaline system for dissolution; therefore, the residues are effectively purified. Ultimately, amorphous sodium titanate is generated. 3.3. Characterization and Activity Test of Regenerated Photocatalysts 3.3.1. Acquisition of Regenerated Photocatalyst Dopants A photochemical decomposition method was employed to obtain Fe dopants. In the process of H 2 C 2 O 4 leaching, it is known through calculation that the leaching rate of impurity Fe 2 O 3 is comparable to that of V 2 O 5 , reaching up to 85.3%, as shown in Table 2 . Fe 2 O 3 undergoes redox reaction in oxalic acid solution, thus forming the complex Fe(C 2 O 4 ) 2 2− existent in the solution [ 28 ]. Equation (8) shows the redox reaction of Fe with oxalic acid. However, the stability constant of the Fe(C 2 O 4 ) 2 2− complex is only 10 4.52 , and the stability in solution is low [ 29 ]. FeC 2 O 4 can be slowly precipitated from oxalic acid leaching solution after exposure to sunlight for a long time. Figure 7 shows the XRD pattern of precipitation of oxalic acid leaching solution after standing. The main components of precipitation are determined as FeC 2 O 4 ·2H 2 O and CaC 2 O 4 ·H 2 O. After digestion of the precipitate, the content of FeC 2 O 4 ·2H 2 O was measured by ICP to be 71.04%. We then further purified treated as-obtained Na 2 TiO 3 with dilute sulfuric acid, to obtain Re-TiO 2 precursor. Finally, after ferrous oxalate doping and calcination, the regenerated TiO 2 samples could be applied in environmental pollutant. Fe 2 O 3 + 5H 2 C 2 O 4 = 2H 2 Fe(C 2 O 4 ) 2 + 3H 2 O + 2CO 2 (8) 3.3.2. Characterization of Regenerated Photocatalysts Table 4 shows the chemical composition of regenerated photocatalysts. The percentage of TiO 2 contained in Sample-A and Sample-B is 98.16% and 97.38%, respectively, which means that the samples obtained in our work meet the requirements for commercial purposes. In addition, the main impurity in Sample-B is Fe 2 O 3 , with the content of other impurities being less than 0.5%. The morphology and structure of Waste-SCR and Sample-B were characterized by TEM, as shown in Figure 8 . They are comprised of nano spherical particles. The crystal size of the Waste-SCR varies from 20 to 40 nm. By contrast, the crystal size of Sample-B ranges only from 6 to 12 nm. A smaller particle size is conducive to the generation of photogenerated carriers and the adsorption of reactants on the surface, thereby improving the photocatalytic performance. In addition, XPS analysis was also conducted to explore the chemical oxidation of regenerated photocatalysts. As shown in Figure 9 , there are two intense peaks observable for the Ti2p core at the binding energies of 464.4 eV and 458.7 eV in Sample-A and Sample-B, which is attributable to the peaks of 2p1/2 and 2p3/2, respectively, for TiO 2 [ 30 ]. In the O (1s) spectrum, the peaks of Sample-A at 530.0 and 531.8 eV are attributable to the lattice oxygen and the hydroxyl groups [ 31 ], respectively. Compared with Sample-A, the lattice oxygen of Sample-B shifts by 0.25 eV towards higher electron binding energies. This phenomenon is probably attributed to the formation of Ti-O-Fe bonds in the crystal lattice [ 32 ]. In Sample-B, Fe 2p XPS peaks appear at 709.7 and 723.0 eV, which is ascribed to the binding energies of Fe 2p3/2 and Fe 2p1/2, respectively. It is indicated that the dopant of Fe is in the chemical state of Fe 3+ in the sample [ 33 ]. The optical properties of the regenerated catalysts were characterized by UV-VIS absorption spectroscopy. As shown in Figure 10 a, Sample-A exhibits an increased absorbance in the broad UV−vis region, compared to the pure P25. After doping with iron, the regenerated catalyst exhibited a further red shift, which can be attributed to the Fe 3+ doping that led to a more efficient transfer and separation of photogenerated electrons and holes. According to the Tauc Plot method, band gap energy can be estimated from the plot of (Ahν)1/2 versus photo energy (hν), as shown in Figure 10 b. The band gap value of P25 is 2.82 eV. Relative to P25, the band gap value of Sample-A is 2.59 eV, which suggests a narrow band gap. After doping with iron, the band gap of the regenerated catalyst was further reduced to 2.43 eV, which is attributed to the bond formed between Fe-O-Ti and excited photon energies reduction. This resulted in low band gap energy [ 30 ]. 3.3.3. Evaluation of Photocatalytic Activities Photocatalytic efficiency of the regenerated photocatalysts and P25-TiO 2 for degrading dyes (RhB) was evaluated through the simulation of sun-light irradiation, as shown in Figure 11 . P25-TiO 2 , Sample-A and Sample-B photodegraded 73.2%, 82.3%, and 94.7% of 10 mg/L RhB, respectively, under stimulated sun-light for 40 min. When RhB concentration increased to 20 mg/L, more than 84.2% of dye was photodegraded in the presence of Sample-B for 60 min, in comparison with 65.4% and 72.9% of the dye degraded by P25-TiO 2 and Sample-A for 60 min, respectively. On this basis, the apparent rate constant (κ app ) for the photocatalytic oxidation of RhB with different products was evaluated using a pseudo-first-order model, which is expressed as follows: ln(C 0 /C t ) = κ app t (9) where, κ app represents the apparent rate constant; C t denotes the solution-phase concentration of dyes; C 0 refers to the initial concentration at t = 0; and t stands for the reaction time. The values of apparent rate constant κ app are also listed in Figure 11 . As shown in the table as an inset of Figure 11 , the slope of Sample-B (0.0725 min −1 ) is 2.14 and 1.64, respectively, times that of P25-TiO 2 and Sample-A for the photodegradation of 10 mg/L RhB. Meanwhile, the slope of Sample-B at a dye concentration of 20 mg/l reached a level that is 1.72 and 1.45 times higher, compared to P25-TiO 2 and Sample-A, respectively. According to photodegradation results, the samples doped with Fe produced a better photocatalytic performance. The mechanism of enhanced photocatalytic activity can be summarized as: a small amount of Fe 3+ can inhibit the recombination of photoexcited electrons and holes, and acts as a temporary photo-generated electron or hole-trapping site [ 34 ]. The reaction steps of regenerated samples can be expressed as follows [ 35 ]: TiO 2 + hν → h + + e − Fe 3+ + e − → Fe 2+ Fe 3+ + h + → Fe 4+ Fe 2+ + O 2 → Fe 3+ + O 2 •− Fe 4+ + OH − → •OH + Fe 3+ Firstly, an electron−hole pair is created in regenerated TiO 2 products under sun-light irradiation. Subsequently, part of the Fe 3+ ions can capture photogenerated electrons to form Fe 2+ ions, and another part of the Fe 3+ ions can also react with holes to form Fe 4+ ions. Fe 4+ and Fe 2+ are relatively unstable compared to Fe 3+ with half-filled d orbitals (d5). Consequently, there is a tendency that Fe 2+ and Fe 4+ react with adsorbed O 2 and surface hydroxyl groups (−OH), respectively, to form highly reactive species O 2 •− and •OH, and regenerate Fe 3+ . After several repeated O 2 •− and •OH attacks, dye degrades to produce CO 3.4. Flow Sheet Establishment Based on the experiments, a flow sheet was established, as shown in Figure 12 . With regards to the oxalic acid leaching step, 86.8 % of the vanadium leaching efficiency was obtained with a H 2 C 2 O 4 addition of 1 mol/L, at a leaching temperature of 100 °C. Meanwhile, 85.3% of iron impurity was also leached. Subsequently, the iron impurity was successfully precipitated as a value-added product of FeC 2 O 4 ·2H 2 O, with a content of 71.04%. With regards to the NaOH leaching step, 98.6 % of the tungsten leaching efficiency was obtained with a NaOH addition of 8 mol/L, at a leaching temperature of 150°C. Residue-B was washed with dilute H 2 SO 4 to obtain a regenerated photocatalyst precursor. Alternatively, the precursor was directly calcined to obtain Sample-A with 98.16% TiO 2 , or it was mixed with FeC 2 O 4 and calcined to obtain Sample-B, with 97.38% TiO 2 and 0.64% Fe 2 O 3 . Finally, the regenerated TiO 2 samples could be directly used for efficient degradation of dyes under sunlight. 4. Conclusions In this paper, a clean, eco-friendly, and novel method was proposed to recycle V and W, and prepare TiO 2 photocatalysts regenerated from Waste-SCR catalysts. With regards to the acid-alkaline leaching process, the optimum conditions of oxalic acid leaching were finalized as 100°C and 1.0 mol/L, which led to the leaching rate of 86.8% for V. The optimum conditions were 150°C and 8.0 mol/L for sodium hydroxide leaching, with the leaching rate of W reaching 98.6% under these conditions. Oxalic acid leaching made no difference to the phase structure of the residue. After alkali leaching, anatase TiO 2 undergoes structural reorganization and transforms into amorphous titanates with a high specific surface area. In addition, sulfate impurities bound to the surface of TiO 2 and molding aids were effectively removed, which led to effective purification. The content of the regenerated TiO 2 product was higher than 97.3%, and thus met commercial requirements. The FeC 2 O 4 precipitated during the acid leaching process was doped into the regenerated TiO 2 product as an iron source, thereby improving the photocatalytic performance. Regenerated TiO 2 photocatalysts exhibited a higher photocatalytic efficiency than P25-TiO 2 to oxidize RhB under simulated solar irradiation. This experimental process contributes a complete, eco-friendly, and economical method to the recycling of Waste-SCR catalysts. Author Contributions Methodology, K.C. and L.X.; validation, K.C., Y.L. and L.X.; formal analysis, B.M. and Y.Y.; data curation, K.C.; writing—original draft preparation, K.C.; writing—review and editing, Y.Y.; visualization, B.M.; supervision, Y.L. and L.X. All authors have read and agreed to the published version of the manuscript. Funding This research received no external funding. Data Availability Statement The data used to support the findings of this study are available from the corresponding author upon request. Conflicts of Interest The authors declare no conflict of interest. References Kompio, P.G.W.A.; Brueckner, A.; Hipler, F.; Manoylova, O.; Auer, G.; Mestl, G.; Gruenert, W. V 2 O 5 -WO 3 /TiO 2 catalysts under thermal stress: Responses of structure and catalytic behavior in the selective catalytic reduction of NO by NH 3 . Appl. Catal. B-Environ. 2017 , 217 , 365–377. 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Preparation, characterization and visible-light-driven photocatalytic activity of Fe-doped titania nanorods and first-principles study for electronic structures. Appl. Catal. B Environ. 2009 , 90 , 595–602. [ Google Scholar ] [ CrossRef ] Figure 1. XRD spectra of Waste-SCR catalysts. Figure 1. XRD spectra of Waste-SCR catalysts. Figure 2. Thermodynamic calculations during oxalic acid leaching and alkali leaching. ( a ) Relationship between Gibbs free energy ΔG and temperature; ( b ) Relationship between enthalpy change ΔH and temperature. Figure 2. Thermodynamic calculations during oxalic acid leaching and alkali leaching. ( a ) Relationship between Gibbs free energy ΔG and temperature; ( b ) Relationship between enthalpy change ΔH and temperature. Figure 3. ( a ) Effect of H 2 C 2 O 4 concentration on the V, W, and Ti leaching efficiencies. ( b ) XRD patterns of Residue-A at different H 2 C 2 O 4 concentration. ( c ) Effect of reaction temperature on the V, W, and Ti leaching efficiencies. ( d ) XRD patterns of Residue-A at different reaction temperatures. Figure 3. ( a ) Effect of H 2 C 2 O 4 concentration on the V, W, and Ti leaching efficiencies. ( b ) XRD patterns of Residue-A at different H 2 C 2 O 4 concentration. ( c ) Effect of reaction temperature on the V, W, and Ti leaching efficiencies. ( d ) XRD patterns of Residue-A at different reaction temperatures. Figure 4. ( a ) Effect of NaOH concentration on the W leaching efficiencies. ( b ) XRD patterns of Residue-B at different NaOH concentrations. ( c ) Effect of reaction temperature on the W leaching efficiencies. ( d ) XRD patterns of Residue-B at different reaction temperatures. Figure 4. ( a ) Effect of NaOH concentration on the W leaching efficiencies. ( b ) XRD patterns of Residue-B at different NaOH concentrations. ( c ) Effect of reaction temperature on the W leaching efficiencies. ( d ) XRD patterns of Residue-B at different reaction temperatures. Figure 5. FT-IR results for Waste-SCR, Residue-A, and Residue-B. Figure 5. FT-IR results for Waste-SCR, Residue-A, and Residue-B. Figure 6. BET results for Waste-SCR, Residue-A, and Residue-B: ( a ) N 2 adsorption-desorption isotherms; and ( b ) BJH pore size distribution. Figure 7. XRD spectra of precipitates from H 2 C 2 O 4 leachate after standing. Figure 7. XRD spectra of precipitates from H 2 C 2 O 4 leachate after standing. Figure 8. ( a ) TEM image of Waste-SCR at 100 nm. ( b ) TEM image of Waste-SCR at 50 nm. ( c ) TEM image of Sample-B at 100 nm. ( d ) TEM image of Sample-B at 50 nm. Figure 8. ( a ) TEM image of Waste-SCR at 100 nm. ( b ) TEM image of Waste-SCR at 50 nm. ( c ) TEM image of Sample-B at 100 nm. ( d ) TEM image of Sample-B at 50 nm. Figure 9. XPS spectra of Sample-A and Sample-B for Ti 2p, O 1s, and Fe 2p peaks. Figure 9. XPS spectra of Sample-A and Sample-B for Ti 2p, O 1s, and Fe 2p peaks. Figure 10. ( a ) The UV-vis DRS spectra of P25-TiO 2 and Sample-A and Sample-B; ( b ) band gap energy spectra of P25-TiO 2 and Sample-A and Sample-B. Figure 10. ( a ) The UV-vis DRS spectra of P25-TiO 2 and Sample-A and Sample-B; ( b ) band gap energy spectra of P25-TiO 2 and Sample-A and Sample-B. Figure 11. Photodegradation of: ( a ) 10 mg/L RhB; and ( c ) 20 mg/L RhB under sun-light irradiation. Photocatalytic reaction kinetics of: ( b ) 10 mg/L RhB; and ( d ) 20 mg/L RhB as a function of reaction time. Figure 11. Photodegradation of: ( a ) 10 mg/L RhB; and ( c ) 20 mg/L RhB under sun-light irradiation. Photocatalytic reaction kinetics of: ( b ) 10 mg/L RhB; and ( d ) 20 mg/L RhB as a function of reaction time. Figure 12. Flow sheet for recovery of V and W, and regeneration of TiO 2 photocatalyst. Figure 12. Flow sheet for recovery of V and W, and regeneration of TiO 2 photocatalyst. Table 1. Chemical compositions (wt %) of Waste-SCR. Table 1. Chemical compositions (wt %) of Waste-SCR. TiO 2 WO 3 V 2 O 5 SiO 2 Al 2 O 3 Fe 2 O 3 CaO SO 3 Others 85.49 4.38 0.65 3.36 1.21 0.69 2.18 1.71 0.33 Table 2. Chemical compositions (wt %) of Residue-A and Residue-B. Table 2. Chemical compositions (wt %) of Residue-A and Residue-B. Residue TiO 2 Na 2 O CaO SiO 2 Al 2 O 3 WO 3 V 2 O 5 Fe 2 O 3 Others Residue-A 89.42 0.03 2.01 3.16 0.89 3.57 0.08 0.11 0.73 Residue-B 88.28 8.67 1.88 0.53 0.22 0.10 0.07 0.08 0.17 Table 3. Pore structure parameters for Waste-SCR, Residue-A, and Residue-B. Table 3. Pore structure parameters for Waste-SCR, Residue-A, and Residue-B. Sample Specific Surface Area (m 2 /g) Total Pore Volume (cm 3 /g) Average Pore Diameter (nm) Waste SCR 52.0 0.28 21.3 Residue-A 62.4 0.30 19.0 Residue-B 193.6 0.50 10.4 Table 4. Chemical compositions (wt %) of Sample-A and Sample-B. Table 4. Chemical compositions (wt %) of Sample-A and Sample-B. TiO 2 Fe 2 O 3 SO 3 Na 2 O CaO Al 2 O 3 V 2 O 5 SiO 2 Others Sample-A 98.16 0.05 0.49 0.48 0.14 0.11 0.08 0.34 0.15 Sample-B 97.38 0.64 0.47 0.46 0.37 0.12 0.07 0.31 0.18
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Global scale emission and distribution of sea-spray aerosol: Sea-salt and organic enrichment | Request PDF Request PDF | Global scale emission and distribution of sea-spray aerosol: Sea-salt and organic enrichment | The chemical composition of marine aerosols as a function of their size is an important parameter for the evaluation of their impact on the global... | Find, read and cite all the research you need on ResearchGate Global scale emission and distribution of sea-spray aerosol: Sea-salt and organic enrichment DOI: 10.1016/j.atmosenv.2009.11.013 Abstract The chemical composition of marine aerosols as a function of their size is an important parameter for the evaluation of their impact on the global climate system. In this work we model fine particle organic matter emitted by sea spray processes and its influence on the aerosol chemical properties at the global scale using the off-line global Chemistry-Transport Model TM5. TM5 is coupled to a microphysical aerosol dynamics model providing size resolved information on particle masses and numbers. The mass of the emitted sea spray particles is partitioned between water insoluble organic matter (WIOM) and sea salt components in the accumulation mode using a function that relates the emitted organic fraction to the surface ocean chlorophyll-a concentrations. The global emission in the sub-micron size range of organic matter by sea spray process is 8.2 Tg yr−1, compared to 24 Tg fine yr−1 sea-salt emissions. When the marine sources are included, the concentrations of modelled primary particulate organic matter (POM) increase mainly over the oceans. The model predictions of WIOM and sea salt are evaluated against measurements carried out at Mace Head (Northern Hemisphere) and Amsterdam Island (Southern Hemisphere), showing that in clean marine conditions WIOM marine emissions contribute significantly to POM values. ... Still, the obtained results are controversial. On one side, some field studies in the North Atlantic (Vignati et al., 2010) based on chlorophyll a (Chl a) concentration (a proxy of phytoplankton biomass or productivity) estimations, have postulated a direct coupling between phytoplankton biomass and the production of organic-rich marine primary aerosols (; Vignati et al., 2010). However, by analyzing other biological components combined with atmospheric dynamics, Rinaldi et al. (2013) showed a systematic delay between time series of oceanic Chl a and OM concentrations in atmospheric marine aerosols. ... ... Still, the obtained results are controversial. On one side, some field studies in the North Atlantic (Vignati et al., 2010) based on chlorophyll a (Chl a) concentration (a proxy of phytoplankton biomass or productivity) estimations, have postulated a direct coupling between phytoplankton biomass and the production of organic-rich marine primary aerosols (; Vignati et al., 2010) . However, by analyzing other biological components combined with atmospheric dynamics, Rinaldi et al. (2013) showed a systematic delay between time series of oceanic Chl a and OM concentrations in atmospheric marine aerosols. ... Sea Ice Microbiota in the Antarctic Peninsula Modulates Cloud-Relevant Sea Spray Aerosol Production Sea spray aerosol (SSA) formation plays a major role in the climate system. The Antarctic Peninsula (AP) is affected by the greatest warming occurring in the Southern Ocean; changes in cryospheric and biological processes are being observed. Whilst there is some evidence that organic material produced by ice algae and/or phytoplankton in the high Arctic contributes to SSA, less is known about Antarctic Sea ice (sympagic) regions. To gain insight into the influence of Antarctic Sea ice biology and biogeochemistry on atmospheric aerosol, we report simultaneous water-air measurements made by means of in situ aerosol chamber experiments. For the first time, we present a methodology showing that the controlled plunging jet aerosol chamber settings do not cause major cell disruption on the studied sea ice ecosystems. Larger sea ice phytoplankton cells (>20 µm; mainly diatoms) tend to sediment at the bottom of the chamber (during the 24h experiment) and likely have a minor role on SSA production. When comparing four chamber experiments - we find that the two producing more SSA are the ones with highest abundance of nanophytoplankton cells (<20 µm; mainly nanoflagellates) as well as viruses. Our marine biogeochemical data show two broad groups of dissolved organic carbon: one rich in carbohydrates and proteic material and one rich in humic-like substances; the latter enhancing SSA production. This work provides unique insights into sea ice productivity that modulates SSA production, with potentially significant climate impacts. Further studies of these types are advised in order to see how microbiology impacts the biogeochemical cycling of elements and how aerosols are formed and processed in cold regions. ... Sea spray aerosol (SSA) is an important component of the aerosol population in the marine environment, and given that 70 % of the Earth's surface is covered by oceans, it contributes significantly to the global aerosol budget (Vignati et al., 2010) . In addition, sea spray aerosol plays an important role in climate, with both direct (Bates et al., 2006;Mulcahy et al., 2008;Vaishya et al., 2011;Rap et al., 2013) and indirect radiative effects (O'Dowd et al., 1999;Andreae and Rosenfeld, 2008). ... ... The present SSSF does not include organic matter which is a very important part of the sea spray aerosol, in particular for the smallest particles , which can act as cloud condensation nuclei. Therefore, we suggest to use the OSSA-SSSF to obtain the total sea spray aerosol fluxes and to derive the organic fraction by using the parameterization developed by Rinaldi et al. (2013) in a way it was used before in several other studies Vignati et al., 2010; Gantt et al., 2011). There is also evidence that micro-organisms affect the viscosity of sea water (Seuront et al., 2010) so that biological activity may be taken into account via the viscosity, like the effect of temperature and salinity; however, further studies and parameterizations are required on this topic in order to separate the different effects and relate the viscosity to observables like chlorophyll-a concentrations. ... Understanding constraints on private irrigation adoption decisions under uncertainty in data constrained settings: A novel empirical approach tested on Ecuadorian Cocoa cultivations Article Francesco Cavazza Cristian Jordan Diaz In rural areas of LatinAmerican Countries, irrigation requirements for perennial crops, like cocoa are expected to increase. This paper develops a novel holistic approach to model private investment decisions in irrigation adoption by small and mid-sized cocoa farmers that face competing sources of uncertainty. In agricultural studies data collection through surveys often leads to issues of missing information on key measured variables. Our approach deals simultaneously with the issue of endogeneity of considering diverse risk sources and with the missing values in key covariates. The study considers multiple levels of irrigation adoption in a context where traditional and modern irrigation systems might coexist. The main contributions of this paper are both its methodological approach and its empirical application filling a knowledge gap on irrigation adoption. ... Several studies have also found that measured organic matter in SSA correlates more strongly with ocean [Chl a] than with other satellite-retrieved ocean chemistry variables, such as particulate organic carbon, dissolved organic carbon, and colored dissolved and detrital organic matter (O'Dowd et al., 2004;Sciare et al., 2009;Gantt et al., 2011;Rinaldi et al., 2013). O'Dowd et al. (2008) proposed a MOA emission parameterization, which was further modified by and Vignati et al. (2010) . In this parameterization, the fraction of emitted organic matter in SSA has a linear relationship with ocean [Chl a] and is not dependent on surface wind speed. ... ... Gantt et al. (2011) took a step fur-ther, and developed an emission parameterization in which the organic matter fraction is an empirical function of ocean [Chl a], 10 m wind speed, and aerosol size. Both parameterizations from Gantt et al. (2011) and Vignati et al. (2010) were found to capture the magnitude of MOA concentrations compared to observations, but the parameterization from had a better representation of seasonal variability of MOA concentrations at Amsterdam Island and Mace Head, Ireland . Rinaldi et al. (2013) also developed a MOA emission parameterization that depends on surface wind speed and [Chl a], and by assuming an 8-10 d time lag between upwind ocean [Chl a] and enhanced production of MOA, the correlation between enriched MOA and [Chl a] was improved. ... Effects of marine organic aerosols as sources of immersion-mode ice-nucleating particles on high-latitude mixed-phase clouds Susannah M. Burrows Mixed-phase clouds are frequently observed in high-latitude regions and have important impacts on the surface energy budget and regional climate. Marine organic aerosol (MOA), a natural source of aerosol emitted over ∼ 70 % of Earth's surface, may significantly modify the properties and radiative forcing of mixed-phase clouds. However, the relative importance of MOA as a source of ice-nucleating particles (INPs) in comparison to mineral dust, and MOA's effects as cloud condensation nuclei (CCN) and INPs on mixed-phase clouds are still open questions. In this study, we implement MOA as a new aerosol species into the Community Atmosphere Model version 6 (CAM6), the atmosphere component of the Community Earth System Model version 2 (CESM2), and allow the treatment of aerosol–cloud interactions of MOA via droplet activation and ice nucleation. CAM6 reproduces observed seasonal cycles of marine organic matter at Mace Head and Amsterdam Island when the MOA fraction of sea spray aerosol in the model is assumed to depend on sea spray biology but fails when this fraction is assumed to be constant. Model results indicate that marine INPs dominate primary ice nucleation below 400 hPa over the Southern Ocean and Arctic boundary layer, while dust INPs are more abundant elsewhere. By acting as CCN, MOA exerts a shortwave cloud forcing change of −2.78 W m−2 over the Southern Ocean in the austral summer. By acting as INPs, MOA enhances the longwave cloud forcing by 0.35 W m−2 over the Southern Ocean in the austral winter. The annual global mean net cloud forcing changes due to CCN and INPs of MOA are −0.35 and 0.016 W m−2, respectively. These findings highlight the vital importance for Earth system models to consider MOA as an important aerosol species for the interactions of biogeochemistry, hydrological cycle, and climate change. ... Ocean-atmosphere interactions play a key role in the climate system, from local to global scale. The ocean, 70% of the Earth surface, is the major source of aerosol particles in the atmosphere, in terms of mass (Vignati et al., 2010) . In particular, marine aerosol is considered one of the most significant contributors to the atmospheric particle burden over remote oceanic locations O'Dowd et al., 2008). ... ... In details, Rinaldi et al. (2013) reported that an 8-day time-lagged correlation exists between satellite retrieved CHL concentration and organic enrichment in the SSA measured at MHD, analyzing a data set of marine aerosol samples collected from 2002 to 2009. Said paper improved previous works by Langmann et al. (2008) and Vignati et al. (2010) was the first one to introduce the spatio-temporal correlation approach for investigating the relationship between marine aerosol properties and biological activity. O'Dowd et al. (2015) illustrated a clear dependency of the organic fraction of SSA on biological activity with a 24-day time lag by using high-resolution aerosol chemical composition measurements from 2009 to 2011. ... Linking Marine Biological Activity to Aerosol Chemical Composition and Cloud‐Relevant Properties Over the North Atlantic Ocean The ways in which marine biological activity affects climate, by modifying aerosol properties, are not completely understood, causing high uncertainties in climate predictions. In this work, in‐situ measurements of aerosol chemical composition, particle number size distribution, cloud condensation nuclei (CCN) and ice nucleating particle (INP) number concentrations are combined with high‐resolution sea surface chlorophyll‐a concentration (CHL) and back‐trajectory data to elucidate the relationship between oceanic biological activity and marine aerosol. The measurements were performed during an intensive field campaign conducted in late summer (August‐September) 2015 at the Mace Head Research Station (MHD). At the short time scale (1‐2 months) of the experiment, we observed a clear dependency of the main aerosol physico‐chemical and cloud‐relevant properties on the patterns of biological activity, in specific oceanic regions with a delayed response of about 1‐3 weeks. The oceanic region comprised between 47°−57° N and 14°−30° W was identified as the main source of biogenic aerosols during the campaign, with hints of some minor influence of waters up to the Greenland coast. These spatial and temporal relationships demonstrate that the marine biota influences aerosol properties under a variety of features up to the most cloud‐relevant properties. Such dependency of aerosol properties with oceanic biological activity was previously reported over the North Atlantic Ocean only for multi‐year datasets, where the correlation may be enhanced by coincident seasonalities. A better knowledge of these short time‐scale interactions may lead to a significant improvement in understanding the ocean‐atmosphere‐cloud system, with important impacts on climate science. ... Primary emissions can contain organic material as coated bubbles burst at the ocean's surface, in part derived from the organic-rich microlayer at the ocean surface (Bigg and Leck, 2008;Lion and Leckie, 1981). Marine organic aerosol particle mass is highly dependent on biological productivity in the surface ocean (O'Dowd et al., 2008;Sciare et al., 2009), and some meso-scale and global atmospheric models use Chl-a to predict sea spray organic fractions (Langmann et al., 2008; Vignati et al., 2010) ; however, the impact of seawater organic content on CCN number concentration differs in the literature. Estimates indicate the increase of sea spray mass due to organic enrichment accounts for < 50% increase in CCN abundance (Burrows et al. 2018). ... Sea2Cloud: From Biogenic Emission Fluxes to Cloud Properties in the Southwest Pacific The goal of the Sea2Cloud project is to study the interplay between surface ocean biogeochemical and physical properties, fluxes to the atmosphere and ultimately their impact on cloud formation under minimal direct anthropogenic influence. Here we present an interdisciplinary approach, combining atmospheric physics and chemistry with marine biogeochemistry, during a voyage between 41 and 47°S in March 2020. In parallel to ambient measurements of atmospheric composition and seawater biogeochemical properties, we describe semi-controlled experiments to characterize nascent sea spray properties and nucleation from gas-phase biogenic emissions. The experimental framework for studying the impact of the predicted evolution of ozone concentration in the Southern Hemisphere is also detailed. After describing the experimental strategy, we present the oceanic and meteorological context including provisional results on atmospheric thermodynamics, composition, and flux measurements. In situ measurements and flux studies were carried out on different biological communities by sampling surface seawater from subantarctic, subtropical and frontal water masses. Air-Sea-Tanks (ASIT) were used to quantify biogenic emissions of trace gases under realistic environmental conditions, with nucleation observed in association with biogenic seawater emissions. Sea spray continuously generated produced sea spray fluxes of 34% of organic matter by mass, of which 4% particles had fluorescent properties, and which size distribution ressembled the one found in clean sectors of the Southern Ocean. The goal of Sea2Cloud is to generate realistic parameterizations of emission flux dependences of trace gases and nucleation precursors, sea spray, cloud condensation nuclei and ice nuclei using seawater biogeochemistry, for implementation in regional atmospheric models. ... Liquid fragmentation leading to the formation of droplets aerosols occurs in many natural and technological processes, including diverse phenomena as raindrops splashing on the ground leading to soil erosion or dispersal of spores and micro-organisms, production of sea spray aerosols (SSA), optimizing fuel injection, controlling ink-jet printing quality and enhancing pesticide spray yields in agricultural fields (Bergeron, Bonn, Martin, & Vovelle, 2000;Josserand & Thoroddsen, 2016;Rein, 1993;Yarin, 2006). Understanding therefore the formation of aerosols and their transport is crucial for instance to better account for their role in the earth radiation balance (Vignati et al., 2010) , the dissemination of pesticides in agricultural fields (Bergeron et al., 2000), the airborne contamination in the form of radionuclides in nuclear facilities (Motzkus, Gensdarmes, & Géhin, 2011) and the spreading of diseases in the air as recently highlighted by the COVID-19 pandemic (Balachandar, Zaleski, Soldati, Ahmadi, & Bourouiba, 2020;Wilson, Corbett, & Tovey, 2020). Generally, droplets aerosol consist of a suspension of liquid particles in the air with a negligible settling velocity, corresponding to droplet diameter typically below 100 μm (Renoux & Boulaud, 1998). ... Aerosol generation by liquid jet impingement onto a solid surface ... In recent years, field measurements for the chemical components, sources and formation of marine aerosols have been widely studied in different oceanic areas (Fu et al., 2011;Kang et al., 2019;Kang et al., 2017;Kawamura et al., 2017). Marine aerosols could be contributed by both marine sources (Vignati et al., 2010) and terrestrial sources such as soil dust, biomass burning, fossil fuel combustion and industrial emissions (Fu et al., 2013b;Geng et al., 2019;Han et al., 2006), resulting in complex composition of aerosol particles over sea areas. Moreover, continental outflow may undergo longrange transport to the open ocean area, promoting secondary processes of organic aerosols (Fu et al., 2013a;Lyu et al., 2020;Shang et al., 2017;Yang et al., 2020). ... Chemical characterization of marine aerosols from two cruises over the South China Sea: Importance of biomass burning and secondary formation SCI TOTAL ENVIRON Total suspended particle (TSP) samples were collected during June-July 2015 in the northern South China Sea (NSCS) and August-September 2016 in the western South China Sea (WSCS). Water-soluble ions (WSIs), organic carbon (OC), elemental carbon (EC), and organic compounds were measured. The average concentrations of WSIs, OC, EC and organic compounds were 19.4 ± 10.9 μg m-3, 2.48 ± 1.54 μgC m-3, 0.31 ± 0.25 μgC m-3 and 789 ± 217 ng m-3 in the NSCS, and were 10.2 ± 4.71 μg m-3, 1.76 ± 1.82 μgC m-3, 0.43 ± 0.32 μgC m-3 and 781 ± 342 ng m-3 in the WSCS. In both cruises, sea salt ions (Na+ and Cl-) and secondary inorganic ions (SO42-, NO3-, and NH4+) were the main species of WSIs, accounting for 54.0 % and 43.6 % in the NSCS, and for 35.0 % and 54.0 % in the WSCS. The secondary products (dicarboxylic acids and aromatic acids) (NSCS: 73.3 %; WSCS: 73.9 %) and saccharides (NSCS: 19.0 %; WSCS: 18.0 %) accounted large fractions of organic compounds in aerosol particles over the SCS. These results suggest sea salt emissions and secondary formation are the main sources of the aerosols over the SCS in summer. The positive correlations between the biomass burning tracers (nssK+ and levoglucosan) and OC as well as organic compounds indicated that biomass burning from nearby continents was also an important source of organic aerosols over SCS. Based on back-trajectory analysis and satellite fire spots, Indochina Peninsula and China were proposed as the main continental source areas of non-sea salt WSIs and organic compounds. Our results highlight the significant contribution of continental outflow especially biomass burning and photochemical secondary oxidation to the organic compositions of aerosol particles over the SCS in summertime. ... Some studies have shown that the submicron SSA could transport to site far away from coastal environments with mass concentrations ranging from 1 to 20 μg m − 3 (Bondy et al., 2017). Additionally, SSA is also an important source of bioaerosols (Verdugo et al., 2004;Gantt et al., 2009;Hawkins and Russell, 2010; Vignati et al., 2010; Gantt and Meskhidze, 2013;Bertram et al., 2018;Schiffer et al., 2018). Some biological species, such as exotoxins, endotoxins, and cell fragments emitted from phytoplankton and bacteria, can damage and disintegrate tissue cells in different mammals, resulting in acute inflammatory and anaphylactic reactions (Cheng et al., 2005;Lang-Yona et al., 2014;Medina-Perez et al., 2021;Van Acker et al., 2021). ... A review of atmospheric aging of sea spray aerosols: Potential factors affecting chloride depletion ATMOS ENVIRON Bojiang Su Tao Wang Xinhui Bi Sea spray aerosol (SSA) is the largest natural source of aerosols in the troposphere, and has profound potential significance for climate change, visibility, and human health. It has been shown that the aging process of SSA in the atmosphere by various chemical transformations can result in chloride depletion, releasing HCl, Cl2, ClNO2, etc. These active chlorine species can significantly affect the atmospheric oxidizing capacity in the troposphere and stratosphere. Compared with the fresh SSA, the aged SSA exhibits distinctly different behaviors in hygroscopicity, optical properties, and cloud condensation nuclei (CCN)/ice nuclei (IN) activity. The literature over the past three decades has dramatically broadened the knowledge of the chloride depletion and improved our understanding of the interconnection between the ocean, atmosphere, and SSA. This paper provides a critical review and synthesis of field observations and laboratory studies on chloride depletion of SSA. More specifically, we summarize recent discoveries in the various types of heterogeneous reactions that lead to chloride depletion, the experimental methodology, mechanism and potential influencing factors. General conclusions are drawn that the acidic species, particle size, types and mixing state, and environmental factors have a significant impact on chloride depletion of SSA. Particularly, the difference in mixing state between individual SSA plays a crucial role in chloride depletion but is still ambiguous. Finally, we conclude with a summary on the results and inadequacy of current laboratory and field studies on chlorine depletion of SSA and some future research perspectives. ... DMS, isoprene, amines, and carbohydrates (e.g. Dall'Osto et al. 2017;Zeppenfeld et al. 2021) that would participate, through aerosolization, in the formation of cloud condensation nuclei (Vignati et al. 2010; Carslaw et al. 2013;Zeppenfeld et al. 2021). Likewise, viruses, from the microlayer, could be detectable and "active" in aerosol particles having the ability to travel through the atmosphere to form clouds (Adams et al. 2021). ... Abundance and activity of sympagic viruses near the Western Antarctic Peninsula POLAR BIOL Dolors Vaqué The Western Antarctic Peninsula (WAP) has experienced significant changes in seawater temperature over the past 50 years. This warming affects seawater and sea ice microbial cycling of organic matter, where viral features could play a crucial role in sympagic sea ice melting environments. However, there is a lack of information about the sea ice viral abundances and processes (e.g. lysis rates and carbon release from microorganisms). To gain knowledge of sea ice viral, microbial, and chemical characteristics, we collected four different sea ice samples and their surrounding surface seawater during the Austral summer of 2019 north of the WAP. In each sample, we assessed viral and microbial abundances and environmental parameters. In the sea ice, we also measured viral-driven mortality rates on prokaryotes and protists and the consequent release of organic carbon. The viral and microorganism abundances in the sea ice were higher (4.5 ± 1.9 × 10⁶ viruses mL⁻¹; 1.5 ± 0.7 × 10⁶ prokaryotes mL⁻¹, 9.4 ± 5.0 × 10² protists mL⁻¹) than in the surrounding surface seawater (1.7 × 10⁶ viruses mL⁻¹, 0.4 × 10⁶ prokaryotes mL⁻¹, 7.1 × 10² protists mL⁻¹). Furthermore, viral lytic production on prokaryotes (4.5 ± 0.8 × 10⁵ mL⁻¹day⁻¹) and protists (1.9 ± 1.0 × 10⁴ mL⁻¹ day⁻¹) in sympagic environments had a higher viral impact on carbon release by protist (1.5 ± 1.1 µg C L⁻¹ day⁻¹) than by prokaryotes (0.3 ± 0.1 µg C L⁻¹ day⁻¹). Our results suggest that, after sea ice melting, viral abundances and activities may influence the functioning of the microbial food web by increasing the release of dissolved organic matter, affecting biogeochemical cycles and microbial communities in the underlying surface waters. ... 7]. Under certain conditions, organic matter has been shown to comprise a substantial fraction of the total particle mass, especially for those particles with diameters less than 1 mm, and, on a global scale, upwards of 8 Tg y À1 of primary submicrometer organic aerosol is estimated to originate as SSA 18, 19 which can be compared to global emission estimates of 34-144 Tg y À1 of total primary organic aerosol. 20 Indeed, it is well established that the organic mass fraction of SSA and aerosol diameter are inversely proportional [e.g. ... Probing the impact of a phytoplankton bloom on the chemistry of nascent sea spray aerosol using high-resolution mass spectrometry Sea spray aerosol is the largest natural source of aerosol to Earth’s atmosphere with significant impacts on climate. Despite this, estimates of the impact of sea spray aerosol on Earth’s radiation budget are highly uncertain due to an overall lack of understanding of the physical and chemical factors controlling its composition. Critically, results from studies probing the importance of oceanic biological activity on the amount and type of organic matter present in nascent sea spray aerosol have been ambiguous. Some field studies have shown a relationship between the organic fraction of sea spray aerosol and oceanic primary productivity while others have reported no such relationships. Given this, we have probed the composition of seawater and nascent sea spray aerosol during a phytoplankton bloom in the North Atlantic using a novel liquid chromatography–mass spectrometry method. We observed that the composition of dissolved organic matter present in seawater changed as the phytoplankton bloom progressed over an 18 day period. Further, we observed changes to both the chemical composition of the organic matter present in seawater and the chemical composition of the organic matter present in the sea spray aerosol despite the organic matter mass fraction of the aerosol remaining unchanged. More specifically, we observed that the nascent sea spray aerosol became progressively more enriched in surface-active organic substances as the bloom progressed and that the sea spray aerosol had a distinct organic matter composition compared to the seawater. Thus, our work provides additional insight into the biological dependence of nascent sea spray aerosol composition. ... Regional and global atmospheric models have long represented sea salt aerosol (i.e., the inorganic components of sea spray), but have only recently begun to include parameterizations of the organic components of sea spray that are associated with sea spray aerosol's ice-nucleation activity, for example, Vignati et al. (2010) , Long et al. (2011), Gantt et al. (2011. Most recently, modeling studies have applied existing marine organic aerosol INP parameterizations (McCluskey, Hill, Sultana, et al., 2018;Wilson et al., 2015) to modeled sea spray aerosol (McCluskey, Ovadnevaite, et al., 2018) and evaluated their impact on simulated clouds as CCN and INPs (Burrows, Easter et al., 2022Huang et al., 2018;X. ... Ice‐Nucleating Particles That Impact Clouds and Climate: Observational and Modeling Research Needs Susannah M. Burrows Atmospheric ice‐nucleating particles (INPs) play a critical role in cloud freezing processes, with important implications for precipitation formation and cloud radiative properties, and thus for weather and climate. Additionally, INP emissions respond to changes in the Earth System and climate, for example, desertification, agricultural practices, and fires, and therefore may introduce climate feedbacks that are still poorly understood. As knowledge of the nature and origins of INPs has advanced, regional and global weather, climate, and Earth system models have increasingly begun to link cloud ice processes to model‐simulated aerosol abundance and types. While these recent advances are exciting, coupling cloud processes to simulated aerosol also makes cloud physics simulations increasingly susceptible to uncertainties in simulation of INPs, which are still poorly constrained by observations. Advancing the predictability of INP abundance with reasonable spatiotemporal resolution will require an increased focus on research that bridges the measurement and modeling communities. This review summarizes the current state of knowledge and identifies critical knowledge gaps from both observational and modeling perspectives. In particular, we emphasize needs in two key areas: (a) observational closure between aerosol and INP quantities and (b) skillful simulation of INPs within existing weather and climate models. We discuss the state of knowledge on various INP particle types and briefly discuss the challenges faced in understanding the cloud impacts of INPs with present‐day models. Finally, we identify priority research directions for both observations and models to improve understanding of INPs and their interactions with the Earth System. ... Sea salt aerosols are the main type of aerosol particles in the global coastal zone [30]. Vignati et al. estimated the total global emissions of sea salt aerosols to be about 24 Tg fine yr −1 [31] . Dust aerosols are soil particles suspended in the atmosphere in deserts or areas with erodible dry soils and strong wind [32,33]. ... Global and Regional Variations and Main Drivers of Aerosol Loadings over Land during 1980–2018 Aerosol particles originated from anthropogenic emissions, volcanic eruptions, biomass burning, and fossil combustion emissions, and their radiative effect is one of the most uncertain factors in climate change. Meanwhile, aerosol particles in fine particle size could also cause irreversible effects on the human respiratory system. This study attempted to analyse the spatial and temporal variations of global aerosol optical depth (AOD, 550 nm) during 1980–2018 using MERRA-2 aerosol reanalysis products and to investigate the effects of natural/anthropogenic emissions of different types of aerosols on AOD values. The results show that the global annual mean AOD values kept high levels with significant fluctuations during 1980–1995 and showed a consistent decreasing and less volatile trend after 1995. Spatially, the AOD values are relatively higher in the Northern Hemisphere than in the Southern Hemisphere, especially in North Africa (0.329), Northern India (0.235), and Eastern China (0.347), because of the intensive natural/anthropogenic aerosol emissions there. The sulphate-based aerosols emitted by biomass burning and anthropogenic emissions are the main types of aerosols worldwide, especially in densely populated and industrialized regions such as East Asia and Europe. Dust aerosols are also the main aerosol type in desert areas. For example, the AOD and AODP values for the Sahara Desert are 0.3178 and 75.32%, respectively. Both black carbon aerosols (BC) and organic carbon aerosols (OC) are primary or secondary from carbon emissions of fossil fuels, biomass burning, and open burning. Thus, the regions with high BC and OC aerosol loadings are mainly located in densely populated or vegetated areas such as East Asia, South Asia, and Central Africa. Sea salt aerosols are mainly found in coastline areas along the warm current pathway. This study could help relevant researchers in the fields of atmospheric science, environmental protection, air pollution, and ecological environment to understand the global spatial–temporal variations and main driving factors of aerosol loadings. ... Detected O'Dowd et al., 2004O'Dowd et al., , 2008Yoon et al., 2007;Fuentes et al., 2010; Vignati et al., 2010; Rinaldi et al., 2013;Long et al., 2014;Quinn et al., 2014 an important role in both regional and global biogeochemical cycling (Suttle, 2007;Mojica and Brussaard, 2014). Due to their high abundance and small size (20-200 nm diameter; Fuhrman, 1999), viruses are probably an important component of primary marine aerosol. ... Ocean Aerobiology Article Full-text available Ocean aerobiology is defined here as the study of biological particles of marine origin, including living organisms, present in the atmosphere and their role in ecological, biogeochemical, and climate processes. Hundreds of trillions of microorganisms are exchanged between ocean and atmosphere daily. Within a few days, tropospheric transport potentially disperses microorganisms over continents and between oceans. There is a need to better identify and quantify marine aerobiota, characterize the time spans and distances of marine microorganisms’ atmospheric transport, and determine whether microorganisms acclimate to atmospheric conditions and remain viable, or even grow. Exploring the atmosphere as a microbial habitat is fundamental for understanding the consequences of dispersal and will expand our knowledge of biodiversity, biogeography, and ecosystem connectivity across different marine environments. Marine organic matter is chemically transformed in the atmosphere, including remineralization back to CO 2 . The magnitude of these transformations is insignificant in the context of the annual marine carbon cycle, but may be a significant sink for marine recalcitrant organic matter over long (∼10 ⁴ years) timescales. In addition, organic matter in sea spray aerosol plays a significant role in the Earth’s radiative budget by scattering solar radiation, and indirectly by affecting cloud properties. Marine organic matter is generally a poor source of cloud condensation nuclei (CCN), but a significant source of ice nucleating particles (INPs), affecting the formation of mixed-phase and ice clouds. This review will show that marine biogenic aerosol plays an impactful, but poorly constrained, role in marine ecosystems, biogeochemical processes, and the Earth’s climate system. Further work is needed to characterize the connectivity and feedbacks between the atmosphere and ocean ecosystems in order to integrate this complexity into Earth System models, facilitating future climate and biogeochemical predictions. ... In this formulation, the ocean whitecap coverage fraction, W , is related to U 10 as W = 3.84 × 10 −6 × U 3.41 10 (Monahan and Muircheartaigh, 1980). This size-resolved flux is approximated by two lognormal distributions with number median dry radius values of 0.09 and 0.794 µm and geometric standard deviation of the accumulation and coarse modes of M7, respectively (Vignati et al., 2010a) . The weights of the distributions are determined by requiring that the mapping conserves the integrated number fluxes of particles with dry radius values in the ranges of 0.05-0.5 and 0.5-5 µm. ... EC-Earth3-AerChem: A global climate model with interactive aerosols and atmospheric chemistry participating in CMIP6 This paper documents the global climate model EC-Earth3-AerChem, one of the members of the EC-Earth3 family of models participating in the Coupled Model Intercomparison Project Phase 6 (CMIP6). EC-Earth3-AerChem has interactive aerosols and atmospheric chemistry and contributes to the Aerosols and Chemistry Model Intercomparison Project (AerChemMIP). In this paper, we give an overview of the model, describe in detail how it differs from the other EC-Earth3 configurations, and outline the new features compared with the previously documented version of the model (EC-Earth 2.4). We explain how the model was tuned and spun up under preindustrial conditions and characterize the model's general performance on the basis of a selection of coupled simulations conducted for CMIP6. The net energy imbalance at the top of the atmosphere in the preindustrial control simulation is on average −0.09 W m−2 with a standard deviation due to interannual variability of 0.25 W m−2, showing no significant drift. The global surface air temperature in the simulation is on average 14.08 ∘C with an interannual standard deviation of 0.17 ∘C, exhibiting a small drift of 0.015 ± 0.005 ∘C per century. The model's effective equilibrium climate sensitivity is estimated at 3.9 ∘C, and its transient climate response is estimated at 2.1 ∘C. The CMIP6 historical simulation displays spurious interdecadal variability in Northern Hemisphere temperatures, resulting in a large spread across ensemble members and a tendency to underestimate observed annual surface temperature anomalies from the early 20th century onwards. The observed warming of the Southern Hemisphere is well reproduced by the model. Compared with the ECMWF (European Centre for Medium-Range Weather Forecasts) Reanalysis version 5 (ERA5), the surface air temperature climatology for 1995–2014 has an average bias of −0.86 ± 0.05 ∘C with a standard deviation across ensemble members of 0.35 ∘C in the Northern Hemisphere and 1.29 ± 0.02 ∘C with a corresponding standard deviation of 0.05 ∘C in the Southern Hemisphere. The Southern Hemisphere warm bias is largely caused by errors in shortwave cloud radiative effects over the Southern Ocean, a deficiency of many climate models. Changes in the emissions of near-term climate forcers (NTCFs) have significant effects on the global climate from the second half of the 20th century onwards. For the SSP3-7.0 Shared Socioeconomic Pathway, the model gives a global warming at the end of the 21st century (2091–2100) of 4.9 ∘C above the preindustrial mean. A 0.5 ∘C stronger warming is obtained for the AerChemMIP scenario with reduced emissions of NTCFs. With concurrent reductions of future methane concentrations, the warming is projected to be reduced by 0.5 ∘C. ... In addition, dried sludge debris can be carried by the wind. Similarly, MPs and NPs can be carried in onshore winds in sea salt aerosols (Vignati et al., 2010) , potentially exposing marine workers or individuals residing in coastal regions (Wright and Kelly, 2017); however, the major sources of airborne microscopic particulates, whether at sea or on land, are generally considered to be terrestrial (K. . Airborne MP/NP particulates have been detected widely, with associated risk of inhalation exposure; sources include indoor and outdoor dust, tyres and synthetic fibres from textiles (Dris et al., 2017;Prata, 2018). ... The State of the Art on the Potential Human Health Impacts of Microplastics and Nanoplastics ... The selected parameters are representative for the groups identified by PCA(Fig. coastal areas(Myriokefalitakis et al., 2016; Vignati et al., 2010) . ... Trends of nutrients and metals in precipitation in northern Germany: the role of emissions and meteorology We analyzed the precipitation chemistry for a maritime region in northern Germany (Schleswig–Holstein) from 1997 to 2017 in order to reveal temporal and spatial patterns and to evaluate the role of meteorological factors relative to emission reductions in Germany and Europe. Therefore, we applied several statistical methods such as time series decomposition, principal component, and redundancy analysis. We extracted two main groups: (i) a marine group (Cl, Na, Mg) that was related to natural processes like sea spray input and (ii) an anthropogenic group (Pb, Cd, As, Zn, and nitrogen species) with a terrestrial subgroup (Fe, Al, Mn), which were both related to emissions. These groups were valid for the spatial, seasonal, and annual trend data. Other elements, like Ca, K, total P, and sulfate, were influenced by natural and anthropogenic processes. The seasonal variation of ammonium deposition was caused primarily by ammonia emissions and ancillary by precipitation. Most heavy metals as well as sulfate, nitrate, and ammonium showed decreasing trends in concentrations and deposition fluxes. Only Hg did not show any trend. The decreasing depositions of sulfate and total nitrogen were correlated to emission reductions in Germany. The deposition of most heavy metals was influenced by emission reductions on European scale and meteorological factors such as wind speed and humidity. Hg did not show any correlation with the emission time series in Europe. Instead, it was correlated to the NAO index and wind, implying that global emissions and transport pathways determine the temporal development of Hg depositions. Overall, the study reveals that emission reductions positively influence regional depositions for most investigated substances. The regional spatial patterns of depositions were also influenced by local meteorological factors. View ... Oceanic P emissions associated with sea spray are computed online here based on a sea-salt emission flux parameterization of Vignati et al. (2010) , accounting for fine and coarse modes, with number mode dry radii of 0.09 and 0.794 µm, and lognormal standard deviations of 1.59 and 2.00 for accumulation and coarse particles, respectively. Sea-spray emissions are driven by the model's meteorology, and for the year 2008, the model calculates a total of about 8284 Tg yr −1 of sea-salt emissions (of which 41 Tg yr −1 are in the fine mode). ... Myriokefalitakis bg-13-6519-2016 Article Full-text available Stelios Myriokefalitakis M. Kanakidou ... This is in good agreement but slightly below the global PMOA emission rate of 6.3 Tg yr −1 found in Gantt et al. (2012), who use the same emission parameterisation but apply an additional global scaling factor of 6 in Eq. (3). The value is also within the range of emission rates calculated using different emission parameterisations in the same model (Gantt et al., 2012) and in numerous other modelling studies which span a range of 2-70 Tg yr −1 (see Gantt and Meskhidze, 2013, for a review) but with many studies showing values in the region of 10 Tg yr −1 Lapina et al., 2011; Vignati et al., 2010) . Scaling the PMOA emissions by a factor of 6 in Gantt et al. (2012) was found to lead to improved agreement of surface mass concentrations at Mace Head (53.33 • N,9.90 • W) and Amsterdam Is- land (37.80 • S, 77.57 ... Description and evaluation of aerosol in UKESM1 and HadGEM3-GC3.1 CMIP6 historical simulations Article Full-text available Dec 2020 GMD Jane Mulcahy Colin E. Johnson Colin Jones Andrew Yool We document and evaluate the aerosol schemes as implemented in the physical and Earth system models, the Global Coupled 3.1 configuration of the Hadley Centre Global Environment Model version 3 (HadGEM3-GC3.1) and the United Kingdom Earth System Model (UKESM1), which are contributing to the sixth Coupled Model Intercomparison Project (CMIP6). The simulation of aerosols in the present-day period of the historical ensemble of these models is evaluated against a range of observations. Updates to the aerosol microphysics scheme are documented as well as differences in the aerosol representation between the physical and Earth system configurations. The additional Earth system interactions included in UKESM1 lead to differences in the emissions of natural aerosol sources such as dimethyl sulfide, mineral dust and organic aerosol and subsequent evolution of these species in the model. UKESM1 also includes a stratospheric–tropospheric chemistry scheme which is fully coupled to the aerosol scheme, while GC3.1 employs a simplified aerosol chemistry mechanism driven by prescribed monthly climatologies of the relevant oxidants. Overall, the simulated speciated aerosol mass concentrations compare reasonably well with observations. Both models capture the negative trend in sulfate aerosol concentrations over Europe and the eastern United States of America (US) although the models tend to underestimate sulfate concentrations in both regions. Interactive emissions of biogenic volatile organic compounds in UKESM1 lead to an improved agreement of organic aerosol over the US. Simulated dust burdens are similar in both models despite a 2-fold difference in dust emissions. Aerosol optical depth is biased low in dust source and outflow regions but performs well in other regions compared to a number of satellite and ground-based retrievals of aerosol optical depth. Simulated aerosol number concentrations are generally within a factor of 2 of the observations, with both models tending to overestimate number concentrations over remote ocean regions, apart from at high latitudes, and underestimate over Northern Hemisphere continents. Finally, a new primary marine organic aerosol source is implemented in UKESM1 for the first time. The impact of this new aerosol source is evaluated. Over the pristine Southern Ocean, it is found to improve the seasonal cycle of organic aerosol mass and cloud droplet number concentrations relative to GC3.1 although underestimations in cloud droplet number concentrations remain. This paper provides a useful characterisation of the aerosol climatology in both models and will facilitate understanding in the numerous aerosol–climate interaction studies that will be conducted as part of CMIP6 and beyond. ... Sea spray is the largest aerosol source on Earth by mass, with total global emissions estimated to be 1-3 × 10 16 g yr −1 (Erickson and Duce, 1988; Vignati et al., 2010) . Despite these large emissions, the impact of seawater biogeochemistry on SSA composition and INP activity remains uncertain. ... A link between the ice nucleation activity and the biogeochemistry of seawater Article Full-text available Dec 2020 ATMOS CHEM PHYS Martin J. Wolf Megan Goodell Eric Dong Daniel J. Cziczo Emissions of ice-nucleating particles (INPs) from sea spray can impact climate and precipitation by changing cloud formation, precipitation, and albedo. However, the relationship between seawater biogeochemistry and the ice nucleation activity of sea spray aerosols remains unclarified. Here, we demonstrate a link between the biological productivity in seawater and the ice nucleation activity of sea spray aerosol under conditions relevant to cirrus and mixed-phase cloud formation. We show for the first time that aerosol particles generated from both subsurface and microlayer seawater from the highly productive eastern tropical North Pacific Ocean are effective INPs in the deposition and immersion freezing modes. Seawater particles of composition similar to subsurface waters of highly productive regions may therefore be an unrealized source of effective INPs. In contrast, the subsurface water from the less productive Florida Straits produced less effective immersion mode INPs and ineffective depositional mode INPs. These results indicate that the regional biogeochemistry of seawater can strongly affect the ice nucleation activity of sea spray aerosol. ... Since sub-micron SSAs have a longer life time in the atmosphere, they can show a considerable aerosol effects for a longer time compared to the super-micron SSAs. 4, 5 During bubble bursting, organic, inorganic, and biological materials dissolved in bulk sea water can be transferred into SSA. 2,6 Film and jet drops formation can control the size selective enrichment of surface active organic compounds in SSAs. ... Phase State and Water Uptake Study of Individual Sea Spray Aerosol Particles Using Atomic Force Microscopy Article Jul 2020 Chathuri Kaluarachchi Hansol D Lee Alexei V Tivanski Phase State and Water Uptake Study of Individual Sea Spray Aerosol Particles Using Atomic Force Microscopy - Chathuri Kaluarachchi, Hansol Lee, Alexei Tivanski ... Marine aerosols are one of the most important sources of atmospheric natural aerosol particles at the global level (Spracklen et al., 2008; Vignati et al., 2010) . They directly and indirectly alter the energy Science of the Total Environment 745 (2020) 140773 budget by absorbing and scattering solar radiation and acting as cloud condensation nuclei (CCN) (Quinn et al., 2017;O'Dowd and Leeuw, 2007). ... Effect of sea ice retreat on marine aerosol emissions in the Southern Ocean, Antarctica Article Jul 2020 SCI TOTAL ENVIRON Jinpei Yan Jinyoung Jung Qi Lin Shuhui Zhao ... Its location, straddling the transition between the Ferrel and polar atmospheric circulation cells, gives rise to a relentless eastward procession of cyclonic low-pressure systems, which particularly develop in the southern Indian Ocean and to the south of Australia (Simmonds et al., 2003). Their associated high wind speeds and wave heights promote the generation of SSA, which contributes a major fraction of the global aerosol mass loading (Vignati et al., 2010) . ... Marine productivity and synoptic meteorology drive summer-time variability in Southern Ocean aerosols Article Full-text available Jul 2020 ATMOS CHEM PHYS Joel Alroe Luke T. Cravigan Branka Miljevic Zoran Ristovski Cloud–radiation interactions over the Southern Ocean are not well constrained in climate models, in part due to uncertainties in the sources, concentrations, and cloud-forming potential of aerosol in this region. To date, most studies in this region have reported measurements from fixed terrestrial stations or a limited set of instrumentation and often present findings as broad seasonal or latitudinal trends. Here, we present an extensive set of aerosol and meteorological observations obtained during an austral summer cruise across the full width of the Southern Ocean south of Australia. Three episodes of continental-influenced air masses were identified, including an apparent transition between the Ferrel atmospheric cell and the polar cell at approximately 64∘ S, and accompanied by the highest median cloud condensation nuclei (CCN) concentrations, at 252 cm−3. During the other two episodes, synoptic-scale weather patterns diverted air masses across distances greater than 1000 km from the Australian and Antarctic coastlines, respectively, indicating that a large proportion of the Southern Ocean may be periodically influenced by continental air masses. In all three cases, a highly cloud-active accumulation mode dominated the size distribution, with up to 93 % of the total number concentration activating as CCN. Frequent cyclonic weather conditions were observed at high latitudes and the associated strong wind speeds led to predictions of high concentrations of sea spray aerosol. However, these modelled concentrations were not achieved due to increased aerosol scavenging rates from precipitation and convective transport into the free troposphere, which decoupled the air mass from the sea spray flux at the ocean surface. CCN concentrations were more strongly impacted by high concentrations of large-diameter Aitken mode aerosol in air masses which passed over regions of elevated marine biological productivity, potentially contributing up to 56 % of the cloud condensation nuclei concentration. Weather systems were vital for aerosol growth in biologically influenced air masses and in their absence ultrafine aerosol diameters were less than 30 nm. These results demonstrate that air mass meteorological history must be considered when modelling sea spray concentrations and highlight the potential importance of sub-grid-scale variability when modelling atmospheric conditions in the remote Southern Ocean. ... Sea spray is the largest aerosol source on Earth by mass, with total global emissions estimated to be 1 -3 × 10 16 g yr- , 1988; Vignati et al., 2010) . Despite these large emissions, the impact of seawater biogeochemistry on SSA composition and INP activity remains uncertain. ... A Link between the Ice Nucleation Activity of Sea Spray Aerosol and the Biogeochemistry of Seawater Preprint Full-text available Jun 2020 Martin J. Wolf Megan Goodell Eric Dong Daniel J. Cziczo Emissions of ice nucleating particles from sea spray can impact climate and precipitation by changing cloud formation, precipitation, and albedo. However, the relationship between seawater biogeochemistry and the ice nucleation activity of sea spray aerosols remains unclarified. Here, we demonstrate a link between the biological productivity in seawater and the ice nucleation activity of sea spray aerosol under conditions relevant to cirrus and mixed-phase cloud formation. We show for the first time that aerosol generated from both subsurface and microlayer seawater from the highly productive Eastern Tropical North Pacific Ocean are effective ice nucleating particles in the deposition and immersion freezing modes. Jet droplets aerosolized from the subsurface waters of highly productive regions may therefore be an unrealized source of effective INPs. In contrast, the subsurface water from the less productive Florida Straits produced less effective immersion mode INPs and ineffective depositional mode INPs. These results indicate that the regional biogeochemistry of seawater can strongly affect the ice nucleation activity of sea spray aerosol. ... Sea spray is a major component of our atmospheric aerosol; both directly, as sea salt particles, and indirectly, as it accumulates and carries both organic and inorganic material across the ocean atmosphere boundary. Sea spray emissions have been shown to contribute significantly to particulate organic matter in the atmosphere but the amount of that contribution remains uncertain, with estimates ranging from 7.5-76 Tg year À1 (Vignati et al. 2010; Tsigaridis et al. 2013). Organic matter that concentrates at the air-sea boundary layer is in the direct vicinity of breaking waves and rising bubbles. ... Philippe Le Sager Shuting Yang This paper documents the global climate model EC-Earth3-AerChem, one of the members of the EC-Earth3 family of models participating in the Coupled Model Intercomparison Project phase 6 (CMIP6). EC-Earth3-AerChem has interactive aerosols and atmospheric chemistry and contributes to the Aerosols and Chemistry Model Intercomparison Project (AerChemMIP). In this paper, we give an overview of the model and describe in detail how it differs from the other EC-Earth3 configurations, and what the new features are compared to the previously documented version of the model (EC-Earth 2.4). We explain how the model was tuned and spun up under pre-industrial conditions and characterize the model's general performance on the basis of a selection of coupled simulations conducted for CMIP6. The mean energy imbalance at the top of the atmosphere in the pre-industrial control simulation is −0.10 ± 0.25 W m−2 and shows no significant drift. The corresponding mean global surface air temperature is 14.05 ± 0.16 °C, with a small drift of −0.075 ± 0.009 °C per century. The model's effective equilibrium climate sensitivity is estimated at 3.9 °C and its transient climate response at 2.1 °C. The CMIP6 historical simulation displays spurious interdecadal variability in Northern Hemisphere temperatures, resulting in a large spread among ensemble members and a tendency to underestimate observed annual surface temperature anomalies from the early 20th century onwards. The observed warming of the Southern Hemisphere is well reproduced by the model. Compared to the ERA5 reanalysis of the European Centre for Medium-Range Weather Forecasts, the ensemble mean surface air temperature climatology for 1995–2014 has an average bias of −0.86 ± 0.35 °C in the Northern Hemisphere and 1.29 ± 0.05 °C in the Southern Hemisphere. The Southern Hemisphere warm bias is largely caused by errors in shortwave cloud radiative effects over the Southern Ocean, a deficiency of many climate models. Changes in the emissions of near-term climate forcers (NTCFs) have significant climate effects from the 20th century onwards. For the SSP3-7.0 shared socio-economic pathway, the model gives a global warming at the end of the 21st century (2091–2100) of 4.9 °C above the pre-industrial mean. A 0.5 °C stronger warming is obtained for the AerChemMIP scenario with reduced emissions of NTCFs. With concurrent reductions of future methane concentrations, the warming is projected to be reduced by 0.5 °C. Seasonal characteristics of emission, distribution and radiative effect of marine organic aerosols over the western Pacific Ocean: an analysis combining observations with regional modeling Preprint Full-text available Oct 2020 Jiawei Li Zhiwei Han Pingqing Fu Xiaohong Yao Organic aerosols from marine sources over the western Pacific Ocean of East Asia were investigated by using an online-coupled regional chemistry-climate model RIEMS-Chem for the entire year 2014. Model evaluation against a wide variety of observations from research cruises and in-situ measurements demonstrated a good skill of the model in simulating temporal variation and spatial distribution of particulate matter with aerodynamic diameter less than 2.5 μm and 10 μm (PM2.5 and PM10), black carbon (BC), organic carbon (OC), and aerosol optical depth (AOD) in marine atmosphere. The inclusion of marine organic aerosols apparently improved model performance on OC aerosol concentration, reducing the normalized mean biases from −19 % to −13 % (KEXUE-1 cruise) and −21 % to −3 % (Huaniao Island) over the marginal seas of east China, and from 33 % to 5 % (Dongfanghong II cruise) and from −13 % to 3 % (Chichijima Island) over remote oceans of the western Pacific. It was found that marine primary organic aerosol (MPOA) accounted for majority of marine organic aerosol (MOA) mass in the western Pacific. High MPOA emission mainly occurred over the marginal seas of China and remote oceans of the western Pacific northeast of Japan. The seasonality of MPOA emission is determined by the combined effect of Chlorophyll-a (Chl-a) concentration and sea salt emission flux, exhibiting the maximum in autumn and the minimum in summer in terms of domain average over the western Pacific. The annual mean MPOA emission rate was estimated to be 0.16×10−2 μg m−2 s−1, yielding an annual MPOA emission of 0.78 Tg yr−1 over the western Pacific, which potentially accounted for approximately 8~12 % of global annual MPOA emission. The regional and annual mean near surface MOA concentration was estimated to be 0.27 μg m−3 over the western Pacific, with the maximum in spring and the minimum in winter, resulting from the combined effect of MPOA emission, dry and wet depositions. Marine secondary organic aerosol (MSOA) produced by marine biogenic VOCs (isoprene and monoterpene) was approximately 1~2 orders of magnitude lower than MPOA. The simulated annual and regional mean MSOA was 2.2 ng m−3, with the maximum daily mean value up to 28 ng m−3 over the western Pacific in summer. MSOA had a distinct summer maximum and winter minimum in the western Pacific, generally consistent with the seasonality of marine isoprene emission flux. In terms of annual mean, 26 % of the total organic aerosol concentration was contributed by MOA over the western Pacific, with an increasing importance of MOA from the marginal seas of China (13 %) to remote oceans of the western Pacific (42 %). MOA induced a minor direct radiative effect (DRE), with a domain and annual mean of −0.21 W m−2 at the top of the atmosphere (TOA) under all-sky condition over the western Pacific, whereas the mean indirect radiative effect (IRE) due to MOA at TOA (IREMOA) was estimated to be −4.2 W m−2. MSOA contributed approximately 6 % of the annual and regional mean IREMOA over the western Pacific, with the maximum seasonal mean contribution up to 14 % in summer, which meant MPOA dominated the IREMOA. It was noteworthy that the IREMOA accounted for approximately 32 % of that due to all aerosols over the western Pacific of East Asia, indicating an important role of MOA in perturbing cloud properties and shortwave radiation in this region. Enrichment of calcium in sea spray aerosol in the Arctic summer atmosphere Article Dec 2020 MAR CHEM Pami Mukherjee John R Reinfelder Yuan Gao Significant calcium enrichment relative to seawater was observed in bulk and size-segregated aerosols in the marine atmospheric boundary layer over the Arctic Ocean in summer. The calcium enrichment factor generally increased with decreasing particle size (aerodynamic diameter) in the fine mode (particle size <1.8 μm), especially within the particle size ranges of 1.8 μm to 0.56 μm and 0.18 μm to 0.1 μm. Potassium was slightly enriched and showed a similar trend of enrichment in fine mode particles. No positive enrichment was observed for magnesium. Calcium bound to certain organic compounds and possibly calcareous debris from marine organisms may have contributed to the calcium enrichment in aerosols. Model results predict that observed calcium enrichments would increase hygroscopic growth in both coarse (10 μm and 5.6 μm) and fine (0.56 μm and 1 μm) aerosol particles. Possible alteration of this model result due to interactions with anions notwithstanding, increases in hygroscopic growth would be particularly important in the Arctic summer when sea-salts constitute the major fraction of aerosol dry mass. This study provides unique insights into ocean-atmosphere chemical interactions in the high-latitude Arctic Ocean. Aerosol in Global Atmosphere Chapter Colin O'Dowd Does Marine Surface Tension Have Global Biogeography? Addition for the OCEANFILMS Package Preprint Full-text available Scott Elliott Susannah M. Burrows P. Cameron-Smith Oliver William Wingenter We apply principles of Gibbs phase plane chemistry to and across the entire ocean-atmospheric interface. Surface tension increments support a two dimensional, tangential pressure well known to determine rates of bulk gas, bubble, salt, spray and momentum transfer plus both sensible and latent heat fluxes. Hence it is worth asking whether tension mapping follows from current understanding of two dimensional composition. A history is provided dating back centuries and demonstrating that detrital organic macromolecules are central; subtle surfactant functional variation creates a microforcing field which dissipates turbulent energy at the sub-meter scale. Since we have just distributed major biopolymeric classes emitted as primary organic aerosol, further climate links can be established by considering full planar thermochemistry. Organic microlayer behaviors are reviewed with attention to confined, analog phase transitions among two dimensional “solid, liquid, (and) gaseous” states serving as elasticity indicators. We also discuss surfactant properties of general marine dissolved organic carbon, demonstrating that only proteins and lipids are capable of occupying significant local micro-area. The literature often suggests albumin and stearic acid as best proxies, and so we distribute their concentrations through multilevel global ecodynamic simulations. Consensus distributions are obtained in order to control adsorptive equilibria. Working from conservation of planar free energy, a parametric equation of state is devised relating excess coverage to the surface pressure-modulus. Constant settings for the proxy pair are drawn from laboratory study, and they successfully reproduce frequencies for surfactant solid-to-gas occurrence in ambient compression experiments. Functionally resolved organic measurements are rare and so we group them into super-ecological province tables showing that our bulk concentration estimates are reasonable. Outputs are then fed into a coverage-tension-elasticity code. Resulting contours traverse the critical range for piston velocity, bubble-spray and damping effects on either a regional or seasonal basis. There is also a possibility for widespread microlayer crystallization in polar seas. The concepts are a direct extension of our organic aerosol work, and the two approaches could be inserted into Earth System Models in tandem. Uncertainties in the logic are enumerated and include kinetic and thermochemical factors at multiple scales. But the problems are reducible through molecular modeling coupled to renewed laboratory and field study. Connections to marine colloids-gels, microlayer iron chelation, and linings of the ice channel network are discussed additionally. The UNAM-Droplet Freezing Assay: An Evaluation of the Ice Nucleating Capacity of the Sea-Surface Microlayer and Surface Mixed Layer in Tropical and Subpolar Waters Article Full-text available Jan 2022 ATMOSFERA Luis A. Ladino Javier Juárez Zyanya Itandehui Ramírez Díaz María Fernanda Córdoba Ice nucleating particles (INPs) in the atmosphere are necessary to generate ice crystals in mixed-phase clouds, a crucial component for precipitation development. The sources and composition of INPs are varied: from mineral dust derived from continental erosion to bioaerosols resulting from bubble bursting at the ocean surface. The performance of a home-built droplet freezing assay (DFA) device for quantifying the ice nucleating abilities of water samples via immersion freezing has been validated against both published results and analyses of samples from sea surface microlayer (SML) and bulk surface water (BSW) from the Gulf of Mexico (GoM) and Saanich Inlet, off Vancouver Island (VI), Canada. Even in the absence of phytoplankton blooms, all the samples contained INPs at moderate concentrations, ranging from 6.0x10^1 to 1.1x10^5 L-1 water. The freezing temperatures (i.e., T50, the temperature at which 50% of the droplets freeze) of the samples decreased in order of VI SML > GoM BSW > GoM SML, indicating that the higher latitude coastal waters have a greater potential to initiate cloud formation and precipitation. Chemical characterization of PM2.5 and PM2.5–10 samples collected in urban site in Mediterranean coast of Turkey Article Aug 2020 APR Ahmet Mustafa Tepe Güray Doğan Cities located on Eastern Mediterranean is exposed to both local and distant anthropogenic and natural sources. In this study, to determine the effect of these sources on Particulate Matter (PM) concentrations in a coastal city, particulate matter with diameters less than 2.5 μm (PM2.5) and with diameters between 2.5 and 10 μm (PM2.5−10) were collected once in a two-day period for 24 h between July 2014 and July 2015 in downtown Antalya which is located on the Mediterranean coast of Turkey. Antalya is one of the fast growing city of Turkey with a population of 2.3 million. Samples were analyzed using an energy-dispersive X-ray fluorescence for 15 elements (Na, Mg, Al, Si, S, K, Ca, Ti, V, Mn, Fe, Cu, Zn, As, Pb). Statistical parameters were calculated for all measured elements in fine (PM2.5) and coarse (PM2.5−10) fraction. Crustal and marine elements, such as Ti, Ca, Al and Na were abundant in the course fraction. Only S was found in higher concentration in the fine fraction. Monthly variation of Crustal Enrichment Factor ( EFC) results of Si showed that the area was under influence of non-local crustal dust especially during spring and late summer. EFC also indicated that during winter season, fine fraction K was due to local wood combustion. Source regions of S was determined using Potential Source Contribution Function (PSCF) and compared with previous studies conducted at a rural site of Antalya approximately twenty years ago. Most of the source regions affecting S concentrations at the Eastern Mediterranean region were found out to be same: western Anatolia, Marmara region, the Aegean Sea coasts of Greece and some parts of Bulgaria and Romania. However, due to decrease in SO2 emissions over the northeast coast of Black Sea and between Caspian Sea and Ukraine, the region was not turned up to be a source region. Sea Spray and Gas Transfer Chapter Apr 2020 Allison Staniec Penny Vlahos Edward C. Monahan In this Chapter we investigate the natural complement of bubble plumes (air entrained in water), sea spray (water entrained in air). As air is entrained in the surface ocean under breaking waves, sea spray is generated from the bubble plumes and the breaking waves themselves. In the same way as bubble plumes, the size distribution and volume flux of sea spray is related to wind speed. The work involving sea spray has been modest relative to its counterpart though significant strides have been made. The momentum and heat flux transfer associated with spray droplets has been reasonably characterized, though the role of sea spray in gas exchange has not. We introduce the Andreas Gas Exchange Sea Spray model (AGES) as an effort to advance our knowledge of sea spray-mediated exchange and present a case study of the role sea spray may serve in gas exchange of the North and South Atlantic Ocean. Field Observations of Secondary Organic Aerosols Chapter Apr 2020 Hajime Akimoto Jun Hirokawa In secondary organic aerosol, various kinds of oxygenated compounds are contained. This chapter summarizes our knowledge on global budget of atmospheric aerosols and methodology of characterizing chemical species measured in ambient aerosols. It presents an analysis method of positive matrix factorization based on the measurement by the aerosol mass spectrometer followed by the analysis of the ratios of mass number peak intensity, and elemental ratios. The chapter describes the characteristics of aerosols in the clean marine air little affected by anthropogenic and terrestrial influence. It discusses organic aerosols formation in the forest air focusing on tropical forests in Amazonia and boreal forest in Finland. The chapter introduces studies clarifying the characteristics of aerosols in urban air using the analytical methods. Description and evaluation of aerosol in UKESM1 and HadGEM3-GC3.1 CMIP6 historical simulations Preprint Full-text available Mar 2020 Jane Mulcahy Colin E. Johnson Colin Jones Andrew Yool Abstract. We document and evaluate the aerosol schemes as implemented in the physical and Earth system models, HadGEM3-GC3.1 (GC3.1) and UKESM1, which are contributing to the 6th Coupled Model Intercomparison Project (CMIP6). The simulation of aerosols in the present-day period of the historical ensemble of these models is evaluated against a range of observations. Updates to the aerosol microphysics scheme are documented as well as differences in the aerosol representation between the physical and Earth system configurations. The additional Earth-system interactions included in UKESM1 leads to differences in the emissions of natural aerosol sources such as dimethyl sulfide, mineral dust and organic aerosol and subsequent evolution of these species in the model. UKESM1 also includes a stratospheric-tropospheric chemistry scheme which is fully coupled to the aerosol scheme, while GC3.1 employs a simplified aerosol chemistry mechanism driven by prescribed monthly climatologies of the relevant oxidants. Overall, the simulated speciated aerosol mass concentrations compare reasonably well with observations. Both models capture the negative trend in sulfate aerosol concentrations over Europe and the eastern United States of America (US) although the models tend to underestimate the sulfate concentrations in both regions. Interactive emissions of biogenic volatile organic compounds in UKESM1 lead to an improved agreement of organic aerosol over the US. Simulated dust burdens are similar in both models despite a 2-fold difference in dust emissions. Aerosol optical depth is biased low in dust source and outflow regions but performs well in other regions compared to a number of satellite and ground-based retrievals of aerosol optical depth. Simulated aerosol number concentrations are generally within a factor of 2 of the observations with both models tending to overestimate number concentrations over remote ocean regions, apart from at high latitudes, and underestimate over Northern Hemisphere continents. Finally, UKESM1 includes for the first time a representation of a primary marine organic aerosol source. The impact of this new aerosol source is evaluated. Over the pristine Southern Ocean, it is found to improve the seasonal cycle of organic aerosol mass and cloud droplet number concentrations relative to GC3.1 although underestimations in cloud droplet number concentrations remain. This paper provides a useful characterization of the aerosol climatology in both models facilitating the understanding of the numerous aerosol-climate interaction studies that will be conducted as part of CMIP6 and beyond. Show abstract Show more
https://www.researchgate.net/publication/248344160_Global_scale_emission_and_distribution_of_sea-spray_aerosol_Sea-salt_and_organic_enrichment
Who Invented Bathtubs, Toilets, Showers, and Fountains? Plumbing has always been about sanitation, a concept that goes as far back as ancient times. The History of Plumbing Elizabeth Weintraub Plumbing comes from the Latin word for lead, which is plumbum. Plumbing by definition is a utility that we use in our buildings consisting of the pipes and fixtures for the distribution of water or gas and for the disposal of sewage. The word sewer comes from the French word essouier, meaning "to drain." But how did plumbing systems come together? Surely it didn't happen at once, right? Of course not. Let's go over the main fixtures of modern-day plumbing systems. These include toilets, bathtubs and showers and water fountains. Let There Be Water Fountains The modern drinking fountain was invented and then manufactured in the early 1900s by two men and the respective company each man founded.Halsey Willard Taylorand the Halsey Taylor Company along with Luther Haws and the Haws Sanitary Drinking Faucet Co were the two companies that changed how water was served in public places. Taylor's interest in developing a fountain for drinking water began when his father died of typhoid fever caused by contaminated public drinking water. His father's death was traumatic and motivated him to invent a water fountain to provide safer drinking water. Meanwhile, Haws was a part-time plumber, sheet metal contractor and the sanitary inspector for the city of Berkeley in California. While inspecting a public school, Haws saw children drinking water out of a common tin cup that was tied to the faucet. Because of this, he feared that there was a health hazard in the making because of the way the public was sharing their water supply. Haws invented the first faucet designed for drinking. He used spare plumbing parts, such as taking the ball from a brass bedstead and a self-closing rabbit ear valve. The Berkeley school department installed the first model drinking faucets. Toilets Were Seats Meant for Kings A toilet is a plumbing fixture used for defecation and urination. Modern toilets consist of a bowl fitted with a hinged seat that's connected to a waste pipe where waste is flushed. Toilets are also called privy, latrine, water closet, or lavatory. Contrary to urban legend,Sir Thomas Crapperdid not invent the toilet. Here's a brief timeline of toilets: King Minos of Crete had the first flushing water closet recorded in history and that was over 2,800 years ago. A toilet was discovered in the tomb of a Chinese king of the Western Han Dynasty that dates back to somewhere between 206 BC to 24 AD. The ancient Romans had a system of sewers. They built simple outhouses or latrines directly over the running waters of the sewers that poured into the Tiber River. Chamber pots were used during the middle ages. A chamber pot is a special metal or ceramic bowl that you used and then tossed the contents out (often out the window). In 1596, a flush toilet was invented and built for Queen Elizabeth I by her godson, Sir John Harrington. The first patent for the flushing toilet was issued to Alexander Cummings in 1775. During the 1800s, people would come to realize that poor sanitary conditions caused diseases. Thus having toilets and sewer systems that could control human waste became a priority to lawmakers, medical experts, inventors as well as the general public. In 1829, the Tremont Hotel of Boston became the first hotel to have indoor plumbing with eight water closets built by Isaiah Rogers. Until 1840, indoor plumbing could be found only in the homes of the rich and the better hotels. Beginning in 1910, toilet designs started moving away from the elevated water tank system and more toward a modern toilet with a closed tank and bowl setup. Toilet Paper and Brushes The first packaged toilet paper was invented in 1857 by an American named Joseph Gayetty. It was called Gayetty's Medicated Paper. In 1880, the British Perforated Paper Company created a paper product to be used for wiping after using the toilet that came in boxes of small pre-cut squares. In 1879, the Scott Paper Company began selling the first toilet paper on a roll, though roll toilet paper did not become common until 1907. In 1942, St. Andrew's Paper Mill in Great Britain introduced the first two-ply toilet paper. In the 1930s, the Addis Brush Company created the first artificialChristmasbrush trees, using the same machinery for making their toilet brushes. In general, the type of material used to make a brush and its design was dictated by its intended use. The hair of animals such as horses, oxen, squirrels, and badgers was used in household and toilet-brushes. Various types of plant fibers have also been used, such as the piassava obtained from a Brazilian palm and palmyra bassine derived from the palmyra palm of Africa and Sri Lanka.Brush bristles were joined to handles and backs of wood, plastic or metal. Many household and toilet-brushes were produced by inserting tufts of fibers into holes drilled in brush backs. One of the earliest and most elaborate of showers was the English Regency Shower developed around 1810.
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EWG's Food Scores | Giant Eagle Onion Pre Sliced Bagels, Onion Check out the food score for Giant Eagle Onion Pre Sliced Bagels, Onion from EWG's Food Scores! EWG's Food Scores rates more than 80,000 foods in a simple, searchable online format to empower you to shop smarter and eat healthier. Giant Eagle Onion Pre Sliced Bagels, Onion Lower scores accompany better foods. Image source: Brand Logo EWG Overall Score Breakdown The product score is based on weighted scores for nutrition, ingredient and processing concerns. Generally, nutrition counts most, ingredient concerns next and degree of processing least. The weighted scores are added together to determine the final score.Read more about scores here. EWG Overall Score Breakdown EWG scored on three factors: nutrition, ingredient concerns, and the degree of processing.Read the full scoring methodology. Lower concern N I P Lower concern N Nutrition Concern I Ingredient Concern P Processing Concern Nutrition Concern Details Considers calories, saturated fat, trans fat, sugar, sodium, protein, fiber and fruit, vegetable and nut content to differentiate between healthful and less healthful foods. For more information on nutrition concerns,read our full methodology. Contains 25% of the Institute of Medicine's daily sodium (salt) recommendations based on adequate intake [read more] Per gram, high in protein [read more] This product contains added sugar ingredients: Sugars [read more] The nutrition factors used for scoring Giant Eagle Onion Pre Sliced Bagels, Onion Positive factors Fruit, vegetable, bean or nut content Protein content Fiber content Omega-3 fatty acids Negative factors Calorie density Sugar/low-calorie sweetener content Sodium content Saturated fat content Trans fat content Ingredient Concern Details Considers food additives, pesticides, hormones, antibiotics and contaminants like mercury and BPA, which can affect human health and the environment. For more information on ingredient concerns,read methodology. This product is not certified organic [read more] No ingredient concerns identified for this product [read more] This product has 2 ingredients with concerns: Enzyme This additive is of lower concern in food. Learn why. RIBOFLAVIN This additive is of lower concern in food. Learn why. Processing Concern Details Estimates how much the food has been processed. Considers many factors, chief among them, modification of individual ingredients from whole foods and number of artificial ingredients. For more information on processing concerns,read our full methodology. Product has been classified as having moderate processing concerns Products with moderate and high processing concerns generally have more artificial ingredients, more ingredients that have been significantly modified from whole foods, and more ingredients overall. EWG's Top Findings This product is not certified organic [read more] This product is not certified organic Products bearing the USDA certified organic seal must contain at least 95 percent organic ingredient, and must be produced without the use of synthetic pesticides and fertilizers and free of genetically engineered ingredients. No ingredient concerns identified for this product [read more] No ingredient concerns identified for this product EWG has not identified any ingredient concerns for this product. Contains food additives of lower concern Contains 25% of the Institute of Medicine's daily sodium (salt) recommendations based on adequate intake [read more] Contains 25% of the Institute of Medicine's dai... This product contains a high percentage of the Institute of Medicine's recommended adequate intake for sodium of 1500 mg a day (IOM 2005). This value is much lower than what the FDA requires be listed on food labels -- 2400 mg. Americans average 3,400 mg of sodium a day. Most of this sodium comes from processed foods where sodium is added to mask the lack of freshness by enhancing the flavor, texture or palatability and extending shelf-life (IOM 2010). Many of these uses are for the manufacturers benefit and not the consumer's health as excess sodium intake is linked to high blood pressure, heart disease, stroke and kidney disease (IOM 2010). Per gram, high in protein [read more] Per gram, high in protein Protein is a source of amino acids that are required for the proper growth, maintenance and repair of tissues. It also provides the building blocks for important enzymes and hormones. Protein provides calories and if eaten in excess will be stored as fat. Protein is found in high amounts in beans, nuts, eggs, seafood and meat. Protein is essential to health, but eating too much also carries an environmental and health cost. Learn more: http://www.ewg.org/meateatersguide/ This product contains added sugar ingredients: Sugars [read more] This product contains added sugar ingredients: ... Eating too much of any type of sugar can lead to tooth decay. Added sugars like high fructose corn syrup, honey, sugar and dextrose are more concerning than natural sugars like raisins because they can lead to obesity by adding calories without being accompanied by important nutrients like potassium, vitamin C or fiber. Americans average 22 teaspoons of added sugar a day (NCI 2010; USDA and DHHS 2010). The World Health Organization recommends no more than 6 to 12 teaspoons of added sugar a day for adults, children should eat even less (WHO 2002; WHO 2014). Product has been classified as having moderate processing concerns EWG Food Reports Nearly 500 Ways to Make a Yoga Mat Sandwich EWG's Good Food On A Tight Budget EWG's 2014 Shopper's Guide to Avoiding GE Food Why GE Foods are not "Natural" EWG's Shopper's Guide to Pesticide in Produce Ingredient List From the Package ENRICHED WHEAT FLOUR (WHEAT FLOUR, MALTED BARLEY FLOUR, NIACIN, REDUCED IRON, THIAMIN MONONITRATE, RIBOFLAVIN, FOLIC ACID), WATER, SUGAR, DEHYDRATED ONIONS, YEAST, SALT, VITAL WHEAT GLUTEN, CALCIUM PROPIONATE (PRESERVATIVE), ENZYMES, GUAR GUM, MONOGLYCERIDES, SESAME FLOUR. CONTAINS: WHEAT, SESAME. * Older Product * Discontinued Product Product Images Please note that EWG obtains the displayed images of products from third parties and that the product's manufacturer or packager may change the product's packaging at any point in time. Therefore, EWG assumes no responsibility for the accuracy of images presented. Other Information This product contains the following ingredient(s) that may be genetically engineered or derived from GE crops: Sugars [read more] This product contains the following ingredient(... Scientists have not determined whether GE food poses risks to human health. Still, consumers have many good reasons to avoid eating genetically engineered ingredients, including limited safety studies, the development of "superweeds" and increased pesticide use. For more information on the topic visit: http://www.ewg.org/research/shoppers-guide-to-avoiding-ge-food Note: The presence or absence of genetically engineered ingredients or ingredients derived from GE crops does not affect a product's overall score. Contains ingredients derived from wheat - these are considered major food allergens according to the FDA [read more] Contains ingredients derived from wheat - these... While over 160 food ingredients may cause allergic reactions current Food and Drug Administration (FDA) regulations stipulate that 8 major food allergens must be labeled on products. These allergens include; milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Note: The presence of potential allergens does not affect the overall product score. Nutrition Facts 6.0 servings per containerServing Size1 bagel 47.5 g 95.0 g (1x) 142.5 g 190.0 g (2x) 285.0 g (3x) 380.0 g (4x) Amount Per 95 g Calories 260 % Daily Value (based on a 2,000 calorie diet and adult bodyweight) Update the values for someone: -age- 1-3 years 4-8 years 9-13 years 14-18 years 19-30 years 31-50 years 51-70 years over 70 years -gender/life stage- male female pregnant female lactating female goQUICK FACTS: 1.0 1.0 % Total Fat 1 g 19.0 19.0 % Total Carbs 51 g % Protein 9 gAVOID TOO MUCH: 0.0 0.0 % Saturated Fat 0 g Trans Fat 0.0g 0.0 0.0 % Cholesterol 0 mg 17.0 17.0 % Sodium 380 mg Added Sugar Ingredients: SugarsNUTRIENTS: 7.0 7.0 % Dietary Fiber 2 g Vitamin D (no value on present label) 4.0 4.0 % Calcium 20.0 20.0 % Iron 0.0 0.0 % Potassium 10 mg† Institute of Medicine. 2010. "Dietary Reference Intakes Tables and Application." Accessed April 8, 2014:link
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Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer | Aging The expression of long non-coding RNAs (lncRNAs) is dysregulated in non-small cell lung cancer (NSCLC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in NSCLC. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a and thereby modulating the expression of kallikrein-related peptidase 4 (KLK4). In NSCLC patients, high expression of LINC00858 closely correlated with tumor progression. Thus, targeting the ceRNA network involving LINC00858 may be used as a treatment strategy against NSCLC. Research Paper Volume 9, Issue 2 pp 475—486 Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer Shao-Ping Zhu 1 , , Jun-Yu Wang 2 , , Xian-Guo Wang 1 , , Jin-Ping Zhao 1 , , 1 Department of Cardiothoracic Surgery, ZhongNan Hospital of Wuhan University, 430071 Wuhan, P. R. China 2 Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, 430015 Wuhan, P. R. China * Equal contribution Received: November 27, 2016 Accepted: January 31, 2017 Published: February 6, 2017 https://doi.org/10.18632/aging.101171 The expression of long non-coding RNAs (lncRNAs) is dysregulated in non-small cell lung cancer (NSCLC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in NSCLC. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a and thereby modulating the expression of kallikrein-related peptidase 4 (KLK4). In NSCLC patients, high expression of LINC00858 closely correlated with tumor progression. Thus, targeting the ceRNA network involving LINC00858 may be used as a treatment strategy against NSCLC. introduction Non-small cell lung cancer (NSCLC), accounting for 83% of total lung cancer, is a leading cause of all cancer deaths around the world [1]. Main risk factors for NSCLC are cigarette smoke and air pollution [2,3], and the 5-year survival rate for NSCLC patients is lower than 21%, in spite of great efforts to improve treatment options for patients with NSCLC [1]. Increasing evidence reveals that the tumorigenesis and progression for NSCLC are a complicated process referring multiple epigenetic and genetic alterations [4–6]. Hence, upgrades in our knowledge of the molecular alterations (including genetic, epigenetic, protein expression levels) and understanding their functional significance would provide crucial roles on diagnosis, treatment, and prevention for NSCLC. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs of more than 200 nucleotides (nt), which are involved in tumor cell proliferation, migration, invasion, apoptosis, angiogenesis, and drug resistance [7–10]. Multiple studies have indicated that lncRNAs, including UCA1 [9], ANRIL [8], XIST [11] and NEAT1 [7] are related to NSCLC tumorigenesis. Nevertheless, the detail biological mechanisms and clinical significance of lncRNAs in the oncogenesis and progression of NSCLC still remains largely unknown. Long intergenic non-protein coding RNA 00858 (LINC00857, LOC170425, NR_038220), is a kind of lncRNA whose length is 2685 nucleotides and locates in 10q23.1 (http://www.ncbi.nlm.nih.gov/nuccore/NR_038220.1). Recently, Xu and his colleagues has reported that LINC00858 is highly expressed in lung adenocarcinoma (5.23-fold than normal lung tissues) [12], while until now, the relevance between LINC00858 expression and NSCLC tumorigenesis has not been elaborated yet. Hence, the roles and potential biological mechanisms of LINC00858 on NSCLC still remain to be expounded. Herein, we are committed to explore the potential molecular mechanism of LINC00858 on NSCLC tumorigenesis. We discovered LINC00858 harbors one conserved miR-422a cognate site as the results of overlap for miRDB (http://mirdb.org/cgi-bin/custom.cgi) and PITA software (http://132.77.150.113/cgi-bin/software.pl?dir=mir07&page=mir07_prediction&id=92e74fcfe41795d7f5b5afd3e80009f7), and then we suggested that LINC00858 would act as a competing endogenous RNA (ceRNA) for miR-422a (MIMAT0001339). Bioinformatics analysis using three database, including microRNA.org, TargetScan, and PicTar, revealed that kallikrein-related peptidase 4 (KLK4), a known oncogene, was an underlying target of miR-422a. Collectively, we validated LINC00858 might be a crucial pro-proliferative regulator to facilitate NSCLC progression by regulation of miR-422a- KLK4 pathway. Results LINC00858 is up-regulated in NSCLC and its high level implies a poor prognosis To examine if LINC00858 was over-expressed in NSCLC, we first tested LINC00858 expression in human NSCLC tissues and their counterparts by qRT-PCR method. Results revealed that LINC00858 levels were remarkably higher in 119 NSCLC tissues than that of in their counterparts ( P<0.05) (Fig. 1A-B). Then, we explored LINC00858 expression in NSCLC cell lines, and discovered that LINC00858 was higher expressed in NSCLC cell lines, containing A549, SK-MES-1, H1299, SK-LU-1, H460, H520, 95D, H1975, H157, and SPC-A-1 cell lines, than that of in normal lung epithelial cells, 16HBE (Fig. 1C). LINC00858 are higher expressed in A549 and SPC-A-1 cells among the ten NSCLC cell lines, hence, we selected A549 and SPC-A-1 cells to conduct the forthcoming experiments. Figure 1. Relative LINC00858 expression in NSCLC tissues and cell lines, and its clinical significance. (A-B)Relative expression of LINC00858 expression in NSCLC tissues (n = 119) and in paired adjacent normal tissues (n = 119). LINC00858 expression was examined by qPCR and normalized to GAPDH expression (shown as 2 -ΔCT). (C)Relative expression of LINC00858 expression in NSCLC cell lines and normal lung epidermal cell. * P< 0.05. Means ± SEM are shown. Statistical analysis was conducted using student t-test. LINC00858 facilitates tumor NSCLC cell growth in vitro Having known LINC00858 is high expressed in NSCLC. We then explore its pro-proliferative features and effects on NSCLC. Firstly, we established NSCLC cell lines (A549 and SPC-A-1) with stable over-expressed or knockdown (Using RNAi) for LINC00858. And then, trypan blue staining, CCK8 and colony formation assay were conducted to examine the role of LINC00858 on NSCLC cell growth, and our results revealed knockdown of LINC00858 contributed to a reduction in the cell growth of A549 and SPC-A-1 cells than that of in their blank counterparts (Fig. 2A-E). However, over-expressed LINC00858 facilitated cell growth of A549 and SPC-A-1 cells (Fig. 2A-E), which clearly demonstrated that LINC00858 significantly promoted cell growth in NSCLC cells. Figure 2. LINC00858 promotes tumor NSCLC cell growth in vitro. (A)Relative LINC00858 expression after transfection with sh-LINC00858 or pcDNA3.1-CT-GFP-LIN00858. (B)Statistical analysis of trypan blue staining. (C-D)CCK8 assays of A549 and SPC-A-1 cells after transfection. (E)Shown are representative photomicrographs of colony formation assay after transfection for fourteen days. Assays were performed in triplicate. * P< 0.05. Means ± SEM are shown. Statistical analysis was conducted using student t-test. LINC00858 acts as a ceRNA for miR-422a in NSCLC Recent studies reported lncRNAs could function as molecular sponges or ceRNAs to regulating the biological functions of miRNA. To choose miRNAs interacted with LINC00858, we analyzed the overlap from results of miRDB (http://mirdb.org/cgi-bin/custom.cgi) and PITA software (http://132.77.150.113/cgi-bin/software.pl?dir=mir07&page=mir07_prediction&id=92e74fcfe41795d7f5b5afd3e80009f7) to predict potential miRNAs (results were shown inTable S1andTable S2). In miRDB, miRNAs with target score≥50 were selected, and in PITA, miRNAs with target score target score ΔΔG≤-10 kcal/mol were selected, then intersection was conducted in the selected miRNAs in miRDB and PITA, and miR-422a was gotten as the candidate miRNA (Table S1andTable S2). To further verify whether miR-422a was enrichment in LINC00858, we performed a pull-down assay using a biotin-labeled specific LINC00858 probe. And a biotin- labeled NC probe was used as a negative control. qRT-PCR was conducted after precipitate. Results revealed that miR-422a was much richer in precipitate of LINC00858 probe than that of in NC probe (Fig. 3C). These results reveal that miR-422a directly bind to LINC00858 at the recognitive sites. Additionally, we also performed trypan blue staining to explore the interaction between miR-422a and LINC00858 on NSCLC cell growth, and results revealed miR-422a repressed cell growth both in A549 and SPC-A-1 cells, while when co-transfected miR-422a and pcDNA3.1-CT-GFP-LINC00858, the growth-inhibitory role of miR-422a was reversed, while the growth expedited role of LINC00858 was also hampered (Fig. 3D). These data demonstrated that LINC00858 facilitated cell growth through functioning as a ceRNA for miR-422a in NSCLC cell lines. Figure 3. LINC00858 is a direct target of miR-422a. (A)Screen of the candidate miRNAs that target LINC00858 predicted by miRDB and PITA. (B)Sequence alignment of miR-422a with the putative binding sites within the wild-type regions of LINC00858. (C)Detection of miR-422a using qRT-PCR in the sample pulled down by biotinylated LINC00858probe. (D)Up-regulated miR-422a in A549 and SPC-A-1 cells, which stably over-expressed LINC00858, largely reversed the favorable effects of LINC00858 on cell proliferation. Assays were performed in triplicate. * P< 0.05. Means ± SEM are shown. Statistical analysis was conducted using student t-test. LINC00858’s pro-proliferative roles are partially via spongeing miR-422a, and then activating KLK4 Having confirmed LINC00858 could inversely regulate miR-422a’s inhibitory role on cell growth in NSCLC, we then explore its functional effects. MiRNAs play crucial role on tumor progression [13–20]. To explore the role of miR-422a on NSCLC, we screen miRanda, Targetscan, and PicTar to select underlying predicted targets for miR-422a. We seek out top 100 potential targets (Table S3), and among them, we selected a well-known oncogene, kallikrein-related peptidase 4 (KLK4), which was up-regulated in numerous malignancies, as a potential target (Fig. 4A). Then, we conducted luciferase reporter assays to identify if KLK4 expression was really affected by miR-422a, and results demonstrated that transfection with miR-422a significantly up-regulated the miR-422a expression in A549 and SPC-A-1 cells(Fig. 4B), and miR-422a inhibited luciferase activity in both A549 cells and SPC-A-1 cells that transfected with a wide type (WT) KLK4 3’-UTR reporter plasmid, but no significant inhibition was observed in that of transfected with a mutant (MUT) KLK4 3’-UTR reporter plasmid (Fig. 4C). Moreover, miR-422a decreased the protein expression but had no influence on the mRNA expression for KLK4 in A549 and SPC-A-1 cells (Fig. 4D-E). We then explored the mechanism of miR-422a on NSCLC cell growth. Results of Trypan blue staining revealed miR-422a treatment repressed cell growth and pcDNA3.1-CT-GFP-KLK4 (with a full 3’-UTR mRNA for KLK4) treatment increased cell growth in A549 and SPC-A-1 cells (Fig. 4F). Nevertheless, when treated A549 and SPC-A-1 cells with miR-422a plus pcDNA3.1-CT-GFP-KLK4, the advantageous role of KLK4 on cell growth was repressed by miR-422a, and the growth-inhibitory role of effect of miR-422a was reversed by KLK4 over-expression (Fig. 4F). These data revealed that miR-422a repressed cell growth by directly targeting 3’-UTR of KLK4 mRNA. Additionally, pcDNA3.1-CT-GFP-LINC00858 treatment reversed the growth inhibitory effect of sh-KLK4 in A549 and SPC-A-1 cells (Fig. 4F), which demonstrated that LINC00858 facilitated cell growth partially through up regulation of KLK4. Furthermore, we next explored the role of LINC00858 and miR-422a on the protein expression of KLK4. Results demonstrated that both miR-422a and sh-KLK4 treatment suppressed protein expression of KLK4, while both pcDNA3.1-CT-GFP-LINC00858 and pcDNA3.1-CT-GFP-KLK4 treatment markedly enhanced protein expression of KLK4 in A549 and SPC-A-1 cells (Fig. 4G), separately. Nevertheless, when treated A549 and SPC-A-1 cells with pcDNA3.1-CT-GFP-LINC00858 plus sh-KLK4, the beneficial role of LINC00858 on protein expression of KLK4 was repressed by knockdown of KLK4, and the negative effect of sh-KLK4 was attenuated by over-expression of LINC00858 (Fig. 4G). Additionally, our results also demonstrated the mRNA of KLK4 expression had no significant correction with the expression of miR-422a in NSCLC samples (r 2=0.0171, P=0.1559), and miR-422a did not affect the mRNA of KLK4 in NSCLC cell lines. While over-expressed miR-422a markedly suppressed the protein expression of KLK4, which demonstrated that miR-422a regulated the KLK4 at post-transcription level (Fig. 5). Our data identify that miR-422a directly targets 3’-UTR of KLK4 mRNA, and reveal that LINC00858’s pro-proliferative effects are large in part by negative regulating miR-422a, and then activation of KLK4. Figure 5. The relationship between KLK4 mRNA expression and miR-422a expression in non-small cell lung cancer. Discussion Increasing evidence has revealed lncRNAs might play a crucial role in tumorigenesis, and contributes to a diverse of biological functions in human cancers [8–10]. Up to date, the effects of a handle of lncRNAs in NSCLC tumorigenesis and progression are needed fully elucidated. Recent studies suggest that several lncRNAs are dysregulated in multiple cancers, including NSCLC [21–25]. One of these is nuclear-enriched abundant transcript 1 (NEAT1), which is a highly conserved nuclear lncRNA and a predictive marker for metastasis in lung cancer [22]. In the current study, we discovered that the lncRNA LINC00858 was up-regulated in NSCLC, and exerted a pro-proliferative role. We also discovered that miR-422a is the target of LINC00858. LINC00858 exerted its pro-proliferative role on NSCLC in large part due to its effect to act as a ceRNA for miR-422a, and subsequently activating the KLK4 signaling pathway. Hence, these findings indicate that LINC00858 may function as an oncogene in the modulation of NSCLC progression. To our knowledge, our present work is the first one to direct investigate of the association between LINC00858 expression and NSCLC. In this study, we discovered LINC00858 was markedly higher expressed in NSCLC tissues than that of in their counterparts. Additionally, over-expressing LINC00858 markedly facilitated NSCLC cell growth in vitro, while silencing LINC00858 suppressed it. Collectively, our data imply that LINC00858 may function as an oncogene and be favorable to NSCLC tumorigenesis and progression. Despite LINC00858 has been implied to function as an oncogene, the potential mechanisms by which LINC00858-induced gene expression involved in oncogenesis still remains to be further expounded. Herein, we are committed to excavate a potential biological molecular mechanism of LINC00858 on NSCLC progression. Increasing evidence confirmed that lncRNAs are key regulators in numerous processes in cells via functioning as ceRNAs to control microRNAs [26]. A handle of lncRNAs have been assessed, such as GAS5 [27,28], NEAT1 [22], XIST [29], and CCAT1 [30]. Herein, we explored the role of LINC00858 in NSCLC and found that LINC00858 acted as ceRNA to bind with miR-422a and accommodate its function. It has been reported that miR-422a acted as a potential tumor suppressor was an independent prognostic factor in colorectal cancer [31], and promoted loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma [32], but its role and potential mechanism on NSCLC needed to be warranted. Herein, we found that miR-422a inhibited growth in NSCLC cell lines, and biotin-avidin pull-down assay revealed LINC00858 could pull down miR-422a. Furthermore, our data also demonstrated that miR-422a could inverse the advantageous effects of LINC00858 on cell growth in NSCLC, suggesting LINC00858 exerted an pro-proliferative role on NSCLC progression in large part via repressing miR-422a. Having revealed the critical effect of miR-422a on repressing NSCLC progression, we searched for the potential mechanisms participated in its function. MiR-422a could regulate multiple targeted genes. It has been reported that miR-422a targeted NT5E/CD73 and promoted loco-regional recurrence in head and neck squamous cell carcinoma [32]. But among all of the predicted target genes for miR-422a, we discovered KLK4 functioned as a critical effector of miR-422a. KLK4 is key regulator on the proliferation of several tumor cell lines [33–35], and is associated with higher risk of NSCLC as determined by univariate analysis and confirmed by multivariate analysis [36]. We confirmed that over-expressed KLK4 promoted cell proliferation in NSCLC cell lines, while silencing KLK4 expression suppressed it. Moreover, we predicted KLK4 as a direct target of miR-422a at its 3’-UTR mRNA by bioinformatics, which was confirmed by luciferase reporter assays. Our results also demonstrated that miR-422a regulated the KLK4 at post-transcription level. Additionally, our data also revealed miR-422a acted as a tumor suppressor on NSCLC by directly targeting KLK4. Furthermore, our data also revealed that LINC00858’s pro-proliferative roles are partially via sponging miR-422a, and then activating KLK4. To our knowledge, we first proved that LINC00858 exerts its pro-proliferative effect in part through sponging miR-422a and then up-regulating and activating of KLK4. Our present study supplied an unequivocal evidence for crucial pro-proliferative effects of LINC00858 in NSCLC, and endorsed the conception that LINC00858 might be an alternative pro-proliferative factor for NSCLC. Taken together, our data provide the evidence that targeting LINC00858-miR-422a-KLK4 axis might be an alternative therapeutic strategy, which will help furnish an essential implication for treatment and diagnosis of NSCLC. Materials and Methods Ethical statement For the analyzed tissue specimens, all patients gave informed consent to use excess pathological specimens for research purposes. The protocols employed in this Subjects Committee. The use of human tissues was approved by the institutional review board of the Wuhan University and conformed to the Helsinki Declaration and to the local legislation. Patients offering samples for the study signed informed consent forms. Tissue collection 119 cases of NSCLC tumor tissue samples were obtained from patients who were diagnosed with primary NSCLC at ZhongNan Hospital of Wuhan University (Wuhan, China) from 2009-2014. The use of tissues for this study has been approved by the ethics committee of ZhongNan Hospital of Wuhan University. Before using these clinical materials for research purposes, all the patients signed the informed consent. None of these patients received any pre-operative chemotherapy or radiotherapy. Cell lines and plasmids Ten NSCLC cell lines (A549, SK-MES-1, H1299, 95D, H460, H520, H1975, H157, SK-LU-1, and SPC-A-1) and the 16HBE cell lines were purchased from the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences (Shanghai, China). Cells were cultured in RPMI 1640 (Gibco, Grand Island, NY, USA) medium supplemented with 10% fetal bovine serum (10% FBS), 100 U/ml penicillin, and 100 mg/ml streptomycin (Gibco) in humidified air at 37°C with 5% CO2. Plasmid pcDNA3.1-CT-GFP-KLK4 (NM_004917, with full length of 3’-UTR) and pcDNA3.1-CT-GFP-LINC00858 were prepared by ourselves. RNAi sequence: KLK4: sh-1: CACCGCTGCAGCCAAATCATAAACGCGAACGTTTATGATTTGGCTGCAGC; sh-2: CACCGGTCTGCAGTAAGCTCTATGACGAATCATAGAGCTTACTGCAGACC. LINC00858: sh-1: CACCGGACTTCATGGTTCAGCATCACGAATGATGCTGAACCATGAAGTCC; sh-2: CACCGCAGCAGCCAGATGAGAAATTCGAAAATTTCTCATCTGGCTGCTGC. Cell transfection and stable cell lines Cells were transfected with DNA plasmids using transfast transfection reagent LipofectamineR 2000 (Invitrogen) according to manufacturer's instructions [37]. For screening stable cell lines, forty-eight hours after transfection, cells were plated in the selective medium containing G418 (1000–2000 μg/ml, Invitrogen, Ltd., U.K) for the next 4 weeks or so, and the selective media were replaced every 3 days. Western blot analysis Western blot was performed using the protocol described previously [38–40]. Briefly, the logarithmically growing cells were washed twice with ice-cold phosphate-buffered saline (PBS, Hyclone) and lysed in a RIPA lysis buffer. Cells lysates were centrifuged at 12,000 g for 20 minutes at 4°C after sonication on ice, and the supernatant were separated. After being boiled for 5–10 minutes in the presence of 2-mercaptoethanol, samples containing cells proteins were separated on a 10% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and transferred onto a nitrocellulose membranes. Then blocked in 10% dry milk-TBST (20 mM Tris-HCl [PH 7.6], 127 mM NaCl, 0.1% Tween 20) for 1 h at 37°C. Following three washes in Tris-HCl pH 7.5 with 0.1% Tween 20, the blots were incubated with 0.2 μg/ml of antibody (appropriate dilution) overnight at 4°C. Following three washes, membranes were then incubated with secondary antibody for 60 min at 37°C or 4°C overnight in TBST. Signals were visualized by ECL. The following primary antibodies were used: rabbit anti-KLK4 (Santa Cruz, USA), rabbit anti-GAPDH (Santa Cruz, USA). qRT-PCR RNA isolation and qRT-PCR was performed as described previously [41,42]. GADPH and U6 were used as endogenous controls. In addition, melting curves were used to evaluate non-specific amplification. The relative expression level was calculated using the 2 -ΔΔCtmethod. The primer sequences used in this study are as follows: human KLK4: sense: 5'- CCGCACACTGTTTCCAGAAC-3', antisense: 5'- GTTAGCGAGCAAGGGTCTGT-3', product length is 140; human LINC00858: sense: 5'- CCCAGCTCCTTACACACGTT-3', antisense: 5'- TTCAGAGGCCTGCATCACTG-3'; human GAPDH: sense: 5'-CTCTGCTCCTCCTGTTCGAC-3', antisense: 5'-ACCAAATCCGTTGACTCCGA -3'. The formula and its derivations were obtained from the ABI Prism 7300 sequence detection system user guide. Statistical analysis was performed on the fold change. Colony formation assay Luciferase Reporter Assays Luciferase reporter assays was conducted as described previously [4]. CCK8 Assay Cell growth was measured using the cell proliferation reagent WST-8 (Roche Biochemicals, Mannheim, Germany). After plating cells in 96-well microtiter plates (Corning Costar, Corning, NY) at 1.0× 10 3/well, 10 μL of CCK8 was added to each well at the time of harvest, according to the manufacturer’s instructions. One hour after adding CCK8, cellular viability was determined by measuring the absorbance of the converted dye at 450 nm. Trypan blue staining Cell viability was assessed using the trypan blue (Lonza, Basel, Switzerland) exclusion method. The A549 and SPC-A-1 cells were seeded in 24-well culture plates at a density of 3 × 10 5cells per well, and the cells were then transfected with Vector, miR-422a, pcDNA3.1-CT-GFP-KLK4, miR-422a plus pcDNA3.1-CT-GFP-KLK4, pcDNA3.1-CT-GFP-LINC00858, sh-LINC00858, or pcDNA3.1-CT-GFP-LINC00858 plus sh-LINC00858. Each cell suspension was mixed with an equal volume of 0.4% trypan blue solution, and the living cells were quantified using a hemocytometer. The cells were also counted using a microscope. The data are representative of three independent experiments performed on different days. RNA pull-down assays LINC00858 transcripts were transcribed using T7 RNA polymerase (Ambio life) in vitro, then by using the RNeasy Plus Mini Kit (Qiagen) and treated with DNase I (Qiagen). Purified RNAs were biotin-labeled with the Biotin RNA Labeling Mix (Ambio life). Positive control, negative control and Biotinylated RNAs were mixed and incubated with A549 and SPC-A-1 cell lysates. Then, magnetic beads were added to each binding reaction, and incubated at room temperature. Finally, the beads were washed, and the eluted proteins were detected by western blot analysis. Statistical analysis Statistical analyses were carried out using SPSS 23.0 statistical analysis software (SPSS Inc., Chicago, IL, USA). Two independent sample t-test or One-Way Analysis of Variance (ANOVA) was performed using SPSS 20.0 software to assess significant differences in measured variables among groups. All data are presented as mean ± standard error of mean (SEM) for three independent experiments. A Pvalue < 0.05 was considered statistically significant. Supplementary Materials Supplementary Table 1 Supplementary Table 2 Supplementary Table 3 Conflicts of Interest The authors declare no conflict of interest. References 1. Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R, Jemal A. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016; 66:271–89. https://doi.org/10.3322/caac.21349 [ PubMed ] 2. Wen J, Fu JH, Zhang W, Guo M. Lung carcinoma signaling pathways activated by smoking. Chin J Cancer. 2011; 30:551–58. https://doi.org/10.5732/cjc.011.10059 [ PubMed ] 3. Sax SN, Zu K, Goodman JE. Air pollution and lung cancer in Europe. 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Oncotarget. 2015; 6:39756–92. https://doi.org/10.18632/oncotarget.5476 [ PubMed ] Corresponding Author Shao-Ping [email protected] Keywords long intergenic non-protein coding RNA 00858 (LINC00858) hsa-miRNA-422a (miR-422a) kallikrein-related peptidase 4 (KLK4) non-small cell lung cancer (NSCLC) tumorigenesis Table of Contents Abstract introduction Results Discussion
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AIM25 collection description Iran: The Making of US Policy, 1977- 1980, is a themed microfiche collection which presents an integrated record of US foreign policy relating to Iran... Microform: Iran: The Making of US Policy, 1977-1980 Identity Statement Reference code(s) : GB 0099 KCLMA MFF 11 Held at : Liddell Hart Centre for Military Archives, King's College London Click here to find out how to view this collection at http://www.kingscollections.org/catalogues/lhcma › Full title : Microform: Iran: The Making of US Policy, 1977-1980 Date(s) : 1943-1980, 1990 Level of description : Collection (fonds) Extent : 565 microfiche Name of creator(s) : The National Security Archive, from sources at US national security agencies, principal of which were Context Administrative/Biographical history: The microfiche collection focuses on US foreign policy towards Iran and events in Iran, 20 Jan 1977-29 Jan 1980. This period coincides with the beginning of the relationship between Mohammad Reza Pahlavi, Shah of Iran, and the US administration under President James Earl 'Jimmy' Carter, Jr, through to the failure of American policy efforts towards the revolutionary Iranian government, which became symbolised by the seizing of the US Embassy in Teheran, Iran, in which 66 Americans were taken hostage by followers of Shiite cleric Ayatollah Ruhollah Khomeini, 4 Nov 1979. As a result of the embassy seizure, President Carter asked Cyrus Roberts Vance, US Secretary of State, to co-ordinate a secret inter-agency appraisal of US involvement in Iran since 1945. The resulting report, known as the 'White Paper', and its 12,000 pages of supporting documentation, provided the White House with an overview of US relations with an allied Iran, 1945-1978. The microfiche collection ends 29 Jan 1980, the date on which the 'White Paper' was transmitted to Zbigniew Brzezinski, US National Security Adviser, by the US State Department's Policy Planning Staff.This document collection originated from investigations done by newspaper reporter Scott Armstrong for his five-part series entitled 'The Fall of the Shah of Iran', published in the Washington Post, 25-30 Oct 1980. This newspaper series first revealed the existence of the so-called 'White Paper'. With the revelation of its existence, then researchers filed Freedom of Information Act (FOIA) requests for the 'White Paper' itself and for the background documents used in its preparation. In addition, the Iranians who seized the US Embassy in Teheran captured material therein including official foreign policy memoranda and cables relating to declining relations between the US and Iran. These documents were subsequently published in Teheran, where they became known collectively as 'The Documents From the Den of Espionage', smuggled into the US, and eventually brought to the attention of Armstrong. Armstrong's subsequent five-part series of articles in the Washington Post entitled 'Iran Documents Give Rare Glimpse of a CIA Enterprise', beginning 31 Jan 1982, revealed to the public for the first time the nature of US foreign policy making in Iran 1977-1980. Documents in this microfiche collection are also from US government sources, including the Central Intelligence Agency (CIA). Finally, the US State Department's 'White Paper' and 700 supporting documents detailing US foreign policy decision making is included as are reports originating from the US Department of Defense, the US Department of Justice, the US Arms Control and Disarmament Agency, and the US Army, Navy, and Air Force Content Scope and content/abstract: Iran: The Making of US Policy, 1977- 1980, is a themed microfiche collection which presents an integrated record of US foreign policy relating to Iran, 20 Jan 1977-29 Jan 1980. Included are memoranda, cabled messages, US embassy and consulate messages, Department of State reports, Central Intelligence Agency reports, US National Security Council reports and studies, and academic historical and political studies of the Middle East generally and Iran specifically, 21 Jan 1943-30 Apr 1980. Although the focus of this document set is on the 1977-1980 period, nearly one-third of the documents listed in the catalogue relate to the period prior to 1977. These are materials that were used in the preparation of the major internal inter-agency review of US-Iranian relations, the US Department of State 'White Paper'. The collection covers the beginning of the popular protests and mass demonstrations that resulted in the Iranian revolution of Feb 1979, which overthrew the pro-American monarchy of Mohammad Reza Pahlavi, Shah of Iran, and established the Islamic Republic of Iran. The collection also covers efforts by the US and the Iranian Provisional Government under Prime Minister Mehdi Bazargan to normalise relations between Iran and the US, which were frustrated by challenges from Islamic organisations including the Revolutionary Council. The collection records in detail the US reaction to the Iranian Constitutional Assembly, which pitted secular against religious forces during the drafting of the new constitution and which led to the formal establishment of a theocracy and the loss of Iran as a US strategic ally, Feb-Jun 1979. Documents include US Department of State report detailing the stability of Iran under the Shah and the effectiveness of SAVAK, the Iranian domestic and foreign intelligence agency, as a law enforcement agency, 28 Jan 1977; US Embassy, Teheran, Annual Policy and Resource Assessment report identifying US interests in Iran as stable, 4 Apr 1977; briefing paper for Cyrus Roberts Vance, US Secretary of State, for his first visit with the Shah, 30 Apr 1977; Central Intelligence Agency (CIA) report affirming the stability of the Iranian political regime, Aug 1977; US Department of State cables relating to the police suppression of anti-Shah demonstrations at Qom, the religious centre of Iran's Shiite community, and the resulting series of mass demonstrations against the Shah, Jan-Dec 1978; US Department of State inspection memorandum describing US relations with Iran as excellent, 4 May 1978; US Department of State memoranda concerning meeting of 13 May 1978, at which chief Iranian military and security personnel devised plans to deal with the rise of anti- government demonstrations, 23 May 1978; cable from William H Sullivan, US Ambassador to Iran, relating to the increasing dissent in Iran and the Shah's fears of the religious opposition to his monarchy presented by Ayatollah Ruhollah Khomeini, 1 Jun 1978; US Department of State airgram relating to meeting held between the Shah and Nasser Moghaddam, Director of SAVAK, in which the Shah ordered that all future demonstrations be broken up by force, 22 Jul 1978; US Department of State cable concerning the Iranian armed forces being put on alert in all major towns in Iran following a series of anti-government bombings, 14 Aug 1978; reports from the US Embassy, Teheran, relating to the 'Black Friday' massacre of anti-government protesters in Jelah Square, Teheran, 8 Sep 1978; US Department of State cable relating to riots in Teheran resulting in the destruction of Western businesses and the occupation of the British Embassy, Teheran, 5 Nov 1978; Central Intelligence Agency (CIA) report relating to the wave of anti-government protests in Iran during the spring of 1978, 5 Nov 1978; US Department of State cable from Ambassador Sullivan to the White House urging the US government to consider that the Shah may have to abdicate in favour of a coalition government, 9 Nov 1978; Central Intelligence Agency (CIA) profile of Khomeini describing him as the central figure in the anti-Shah movement and his proposed regime as xenophobic and hostile towards Western interests in the region, 20 Nov 1978; US Embassy reports to Washington, DC, relating to the Shah's departure from Iran, Jan 1979; US Department of State cables relating to the return of Khomeini to Iran from Paris, France, and his subsequent demands for the resignation of the Iranian Provisional Government, Feb 1979; US Embassy reports relating to the establishment of the Islamic Revolutionary Council under the leadership of Khomeini, Feb 1979; US Department of State cables relating to the deteriorating civil situation in Iran and growing anti-US sentiments, culminating in the seizure of the US Embassy, Teheran, and 66 of its employees, Feb-Nov 1979. Access & Use Language/scripts of material:English System of arrangement: The collection is arranged in chronological order Conditions governing access: Open, subject to signature of reader's undertaking form Conditions governing reproduction: Finding aids: Summary guide entry on-line at http://www.kcl.ac.uk/lhcma/top.htm, and published detailed catalogue available in hard copy in the Centre's reading room, Iran: The Making of US Policy, 1977-1980 (Chadwyck-Healey and The National Security Archive, Alexandria, VA, 1990) Archival Information Archival history: Immediate source of acquisition: The National Security Archive, Washington, DC, USA Allied Materials Publication note: Description Notes Archivist's note: Rules or conventions: Date(s) of descriptions:Date of compilation: Aug 1999
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(PDF) Adaptation across the Lifespan: Towards a Processual Evolutionary Explanation of Human Development PDF | This paper argues that the project of a lifespan perspective in developmental psychology has not yet been systematically pursued. Overall, the... | Find, read and cite all the research you need on ResearchGate Adaptation across the Lifespan: Towards a Processual Evolutionary Explanation of Human Development April 2023 Integrative Psychological and Behavioral Science DOI: 10.1007/s12124-023-09767-y CC BY 4.0 Authors: Universität Hildesheim Abstract This paper argues that the project of a lifespan perspective in developmental psychology has not yet been systematically pursued. Overall, the number of age-specific papers far outweighs the number of lifespan approaches, and even approaches that focus on the lifespan as a whole are often restricted to adulthood. Further, there is a lack of approaches that examine cross-lifespan relationships. However, the lifespan perspective has brought with it a "processual turn" that suggests an examination of developmental regulatory processes that are either operative across the lifespan or develop across the lifespan. Accommodative adjustment of goals and evaluations in response to obstacles, loss, and threat is discussed as an example of such a process. Not only is it prototypical of efficacy and change of developmental regulation across the lifespan, but at the same time it makes clear that stability (e.g., of the self)—as a possible outcome of accommodation—is not an alternative to, but a variant of development. Explaining how accommodative adaptation changes, in turn, requires a broader perspective. For this purpose, an evolutionary approach to developmental psychology is proposed that not only views human development as a product of phylogenesis, but also applies the central concepts of the theory of evolution (adaptation and history) directly to ontogeny. The challenges, conditions, and limitations of such a theoretical application of adaptation to human development are discussed. Vol.:(0123456789) Integrative Psychological and Behavioral Science https://doi.org/10.1007/s12124-023-09767-y 1 3 REGULAR ARTICLE Adaptation acrosstheLifespan: T owards aProcessual Evolutionary Explanation ofHuman Development WernerGreve 1 Accepted: 31 March 2023 © The Author(s) 2023 Abstract This paper argues that the project of a lifespan perspective in de velopmental psy - chology has not yet been sys tematically pursued. Overall, the number of age-spe - cific papers far outweighs the number of lifespan appr oaches, and even approaches that focus on the lifespan as a whole are often restricted to adulthood. Further, there is a lack of approaches that examine cross-lif espan relationships. Howe ver, the lifespan perspective has brought with it a "processual turn" that suggests an e xami - nation of developmental regulatory processes that are either operative across the lifespan or dev elop across the lifespan. Accommodative adjustment of goals and evaluations in response to obstacles, loss, and threat is discussed as an example of such a process. Not only is it pro totypical of efficacy and change of developmental regulation across the lifespan, but at the same time it makes clear that stability (e.g., of the self)—as a possible outcome of accommodation—is not an alternative to, but a variant of development. Explaining how accommodativ e adaptation changes, in turn, requires a broader perspective. For this purpose, an evolutionary approach to developmental psychology is proposed that not onl y views human dev elopment as a product of phylogenesis, but also applies the central concepts of the theory ofevo - lution (adaptation and history) directly to ontogeny . The challenges, conditions, and limitations of such a theoretical application of adaptation to human development are discussed. Keywords Adaptation· Lifespan de velopment· Evolutionary developmental psychology· Accommodative de velopmental regulation· Flexibility of goal adjustment· Theoretical interpretation & theory formulation The time of grand theories in psychology, and especially in de velopmental psy - chology, is o ver, one might f ear. Currently , an overarching theory of human * Werner Greve [email protected] 1 Institute forPsychology , University ofHildesheim, Univ ersitaetsplatz 1, 31141Hildesheim, Germany Content courtesy of Springer Nature, terms of use apply. Rights reserved. Integrative Psychological and Behavioral Science 1 3 development is not under discussion, especially no t a theory that would explain why we dev elop: why at all, and why as we do. The last major paradigmatic attempt—the plea for the lifespan approac h in developmental psychology—dates back more than three decades (Baltes, 1987 ). Actually , the expansion of the period of human change under consideration beyond c hildhood and adolescence was not fundamentally new even then; rather , it tied in with perspectives that had already been addressed several times at mid-century , for example by Char lotte Bühler, Erik H. Erikson, and Robert Havighurst (see, e.g., Lerner, 2018 ). But Baltes’ claims that development is not characterized by a specific direction, nor that can it be c harac - terized as progress because gains and losses are discernible at all times, and that no life stage has any privileged importance for de velopment, clearly went be yond the previous approaches. In fact, the lifespan approach is no t a revision of older theories focused on childhood and adolescence forced by empirical data (it had not escaped Freud or Piaget that people do change bey ond adolescence), but a conceptual proposal to use the term “development” differently (i.e., more encompassing) than the classi - cal understanding suggested (Freud and Piaget would no t have called the changes during adulthood and especially older age “development”). The lif e span perspec - tive of developmental psyc hology is, in a word, not a theory. Definitions, ho wever , unlike theories, cannot be proven wrong. Whether the proposed use of the term ‘development’ (including also c hanges in adulthood) is fruitful and useful remains to be seen. The Lifespan Perspective onHuman Developmen t – AProject still Pending For although the lifespan perspective has been generall y approvingly received, and has inspired programmatic handbook contributions (prototypically: Baltes et al., 2006 ) and editions (e.g., Brandtstädter & Lindenberger, 2007 ; Fing er - man etal., 2011 ; Lerner, 2010 ; Staudinger & Lindenberger, 2003 ), it is perhaps not unfair to sum up that these dedicated pleas hav e not succeeded in ensuring that developmental psychology actuall y focuses on the entire life span. In fact, approving references to this perspectiv e (in the introductory paragraphs of books or articles) are often not much more than general statements: the vast major - ity of works in developmental psy chology either deal with phenomena that are limited to individual life stages (e.g., first languag e acquisition or learning to walk) or with a specific developmental segment of a phenomenon that in princi - ple also occurs in other developmental stages (e.g., emotion regulation in child - hood). Review s (e.g., Lansford, 2018 , on well-being) or textbooks (e.g., Boyd & Bee, 2019 ) ar guing in favor of a lif espan perspective just add sections or chap - ters on adulthood and old age, extending the time span for dev elopment, but do not integrate them. Relatively f ew investig ations attempt to look at specific phe - nomena across the lifespan (for a summary , see also Moersdorf etal., 2022 ), for Content courtesy of Springer Nature, terms of use apply. Rights reserved. 1 3 Integrative Psychological and Behavioral Science example, decision-making (Lindow & Lang, 2021 ), or theory of mind (Bernstein etal., 2011 ), or to examine methodological difficulties of this perspective (e.g., with respect to personality inventories: Brandt etal., 2020 ): not rarely, studies and paper still focus largel y on adulthood (e.g., Heckhausen & Schulz, 1995 ; Heckhausen etal., 2010 , 2019 , on control) and thus do not investigate the entire lifespan. The fact that a serious lifespan perspective has rarel y been pursued is proba - bly not so much because fundamental objections to the lifespan perspectiv e (e.g., Bischof, 2008 ) are widely shared. Several methodological problems of the lifes - pan perspective (Moersdorf et al., 2022 ) ar e also unlikely to be insurmountable obstacles; in particular, problems of (ensuring) measurement equivalence across ages are not a problem specific to this perspective, but are also serious within shorter time periods in which considerable qualitative development occurs (cog - nitive development in c hildhood offers many examples of this; Bjorklund & Cau - sey, 2018 ; Care y, 2009 ). Howev er, some conceptual problems of the lifespan approach ha ve also not been sufficiently clarified (Moersdorf et al., 2022 ), which also affect the point discussed here. Perhaps the most far-reac hing is the point raised at the outset that the lifespan approach is not a theory: it does not explain de velopment to extend the time span considered (even if naming systematic chang es across the lifespan as”development” were consensual). Rather , even studies that are explicitl y com - mitted to this approach add changes that occur after adolescence, if systematic enough, to the sequence of phases in the earlier stages of life (chang es in cog - nitive abilities in older and high adulthood are a prototypical exam ple; Baltes, Lindenberger & Staudinger, 2006 ; Baltes e t al., 1999 ). Howe ver, at first glance these approaches hardly go bey ond the (generalized) description of trajectories across life spans. Postulating a seq uence of qualitatively distinguishable stages (across the life course) cannot explain de velopment (Siegler, 1996 ). How ever, the processes that control and regulate—and thus explain—development are rarel y named (Piaget is a notable exception: e.g., Chapman, 1988 ). In f act, phase-ori - ented approaches are not really sufficient ev en from a descriptive perspective: it has become increasingly evident that not only o vertly culture-dependent phenom - ena such as morality or identity, but also phenomena that seem to be e volutionar - ily basal such as attachment are highly conte xt-dependent (Keller etal., 2017 ). It is therefore not surprising that the detailed study of individual objects and phe- nomena is more attractive, for instance the careful in vestigation of the timing, scope, and course of the ability of “theory of mind” (e.g., Bernstein et al., 2011 ; Derksen etal., 2018 ; Rakoczy , 2017 ; Rakoczy & Schmidt, 2013 ; Wellman etal., 2001 ), the physiological and neurological basis of changes in mental functions in old age (e.g., Lövdén etal., 2010 ), or the exact (micro-)course of emotional regulation processes (e.g., Blume et al., 2022 ). Notably, this research is certainly theory-driven, and it has often yielded not only empirical and theoretical insights, but also methodologi- cal advances (e.g., Neubauer etal., 2022 ). But its goal is typically a differentiated clarification of the respective focused phenomenon, rarely its placement in relation Content courtesy of Springer Nature, terms of use apply. Rights reserved. Integrative Psychological and Behavioral Science 1 3 to other phenomena, and even more rarely a placement in a g eneral picture of human development (Tomasello, 2019 , is a no table exception). The Processual Turn: Developmen tal Regulation asaUnifying Perspective onDevelopment The lifespan approach comprises (although not entails) the assumption that the course of human development across the lif espan is not determined by a fixed or innate (e.g., genetical) program or blueprint. Human development is characterized by a high degree of plasticity (Baltes, 1987 ; Lövdén etal., 2010 ), it does not simpl y run along fixed steps, but its course depends on developmental conditions. In par - ticular, modern lifespan approaches share the view that individual self-regulation of development becomes increasingly rele vant from adolescence onw ard (Baltes, 1997 ; Brandtstädter, 2006 ; Brandtstädter & Lerner, 1999 ; Lerner & Busch-Ross - nagel, 1981 ). Beyond universal trajectories and socio-cultural influences (V alsiner, 2000 ), the individual pursuit of developmental goals seem to play an essential shap - ing role: adult development is activ ely and intentionally shaped by the dev eloping individual (Brandtstädter, 2006 ; Lerner & Busch-Rossnagel, 1981 ; Featherman & Lerner, 1985 ). In terms of universal descriptions of life courses, this complicates at first glance the quest for a unified theory of human development in adulthood (and thus across the life span): Life courses are c haracterized by a high degree of indi - viduality (as Charlotte Bühler, 1933 , had emphasized almost a century ago). Howev er, individuality does certainly not preclude a general, universal theory of human behavior and development (V alsiner , 2017 ). Actually , the actional expla- nation of human development marks the beginning of a change of the theoretical perspective. If “action” and the concepts implicit in it such as “goal”, “intention”, or “control”, do regulate human development (at least in adulthood) (Brandtstäd- ter, 2006 ; Brandtstädter & Lerner, 1999 ), then this is a unified and cross-contextual construct relevant for the explanation of (individual) de velopmental trajectories. Accordingly , several lifespan appr oaches examined the role of goal and control for developmental trajectories (Brandtstädter, 1992 ; Freund etal., 2019 ; Freund & Rie- diger, 2006 Heckhausen etal., 2010 , 2019 ). Ye t, certainly individuals cannot be “producers” but at best “co-producers” of their development: not only e xternal constraints but in particular internal precondi- tions for action shape development no less than goals, intentions or decisions and goal-directed (development-related) action. Internal conditions or components of actions, howev er, cannot certainly not be explained in an action-theoretical f ormat (Brandtstädter, 2006 ). Further more, the increase of problems and losses that par- ticularly characterize late adulthood and old age in particular directed the attention to adaptation and compensation processes. Therefore, the role of compensatory and palliative regulatory processes has been a second important focus for dev elopmental theories at the end of the twentieth century, perhaps even the more important one (Baltes, 1997 ; Baltes & Baltes, 1990 ; Brandtstädter, 2006 ; Brandtstädter & Greve, 1994 ; Brandtstädter & Renner, 1990 ; Brandtstädter & Rothermund, 2002 ; Freund, Content courtesy of Springer Nature, terms of use apply. Rights reserved. 1 3 Integrative Psychological and Behavioral Science 2008 ; Freund & Baltes, 2000 ; Freund et al., 1999 ; Heckhausen et al., 2010 , 2019 ; Staudinger & Lindenberger, 2003 ). The in vestigation of possible responses to chal- lenges, blockages and losses in late adulthood and old age links the consideration of lifespan dev elopmental trajectories to the (micro) processes of coping with current challenges: critical life ev ents and current stresses as well as developmental tasks. One will hardly be able to contradict Popper’ s ( 1994 ) famous formulation “all lif e is problem solving” in this general form. Slightly e xaggerated, one could subsequently say that it is the function of development to enable us to sol ve new problems. Since development itself consists of a sequence of c hallenges (problems, crises, tasks), problem solving is obviously constitutiv e for human dev elopment. Since individual development cannot be regulated independently of these micro-pr ocesses (precisely because it consists of them), conceptual links and equivalences between micro-pro- cesses and cross-cutting developmental trajectories are necessary prerequisites for any integrative perspective (Aldwin, 2007 ). The argument by Baltes et al. ( 2006 ) to distinguish several theoretical lev els (from macro- to micro-processes) asks for an integrative perspectiv e that clarifies the inter-level-relationships. One of the difficulties of such integration is that while some responses to challenges and problems can be reconstructed in an intentional format (e.g., as “strategic responses”; e.g., compensatory efforts or systematic recruitment of social support)—by no means all of them. In particular, changing and adjusting goals in content or weight (letting go or dev aluing and revaluing blocked goals, compensatory upweighting of alternative goals, etc.; Brandtstädter & Renner, 1990 ; Brandtstädter & Rothermund, 2002 ; Heckhausen etal., 2010 , 2019 ; Wrosch etal., 2003a , b ) typically does not occur intentionall y and rarely in a controlled man- ner (Brandtstädter, 2006 ). The theoretical approaches mentioned discuss this con- ceptual tension between a personal (actional) response and a subpersonal (proces- sual) regulation (Rothermund etal., 2020 ; Wentura, 2005 ) q uite differently (Boerner & Jopp, 2007 ; Haase etal., 2013 ). However, f or the purpose of the following con- siderations, such differences between these approaches (Kappes & Gre ve, subm.) are less significant than several common points. To begin with, all of these theories of developmental regulation in adulthood and later life share a processual perspectiv e: The focus is alwa ys on developmental regulatory processes (how are challenges and crises resolved?), no t on identifying specific developmental phases or trajectories (who can, shows, or loses what and when?). Actually , this processual perspective is perhaps the more enduring yield of the lifespan perspective: Not so muc h a temporal expansion of the life stages and themes considered as primarily this “processual turn” in developmental psychology might become the most consequential aspect of the lifespan approach. This proces- sual turn may not have been the main intention of these theories at first, and inte- grative potential of the process perspective has been too little exploited, but it does change the view of human ontogenesis. For the purpose of the present argument, two aspects are particularly important. First, the view of regulative processes on human de velopment opens the perspective to explain not only (continuous or discontinuous) chang es, but also stability with reference to one and the same process—depending on the respective realized condi- tions and the level considered. Second, this opens the view of possible integration Content courtesy of Springer Nature, terms of use apply. Rights reserved. Integrative Psychological and Behavioral Science 1 3 of developmental processes in childhood and adolescence that not just e xplain the basic conditions for later stages but rather provide necessary and constitutiv e com- ponents of adult regulatory processes. This might be a more promising way to an integrative lifespan perspective on human de velopment. Stability: AVariant, nottheOpposite ofDe velopment A number of studies have sho wn that the individual preparedness to adjust goals (flexibility of goal adjustment; Brandtstädter & Renner, 1990 ) is a predictor f or the stability of the self and well-being (Brandtstädter & Greve, 1994 ; Brandtstädter etal., 1993 ) and a buffer against a versive circumstances and experiences (e.g., Grev e etal., 2001 ; Greve & Enzmann, 2003 ; Grev e etal., 2017 ; Rühs etal., 2017 ; Thom- sen etal., 2015 ), and, thus, can explain unexpected patterns of findings of “lacking” changes (“well-being paradox”; S taudinger, 2000 ). The development of the self o ver the life span and especially the processes maintaining identity and continuity of the adult self (e.g., Brandtstädter & Greve, 1994 ; Grev e & Wentura, 2003 , 2010 ; Marek etal., 2022 ) can illustrate this thesis in a particular way, making clear ho w the pro- cessual view on development can e xplain different states (dynamically changing as well as appearing stable). Certainly, stability can arise in several w ays. For exam- ple, stability and predictability are useful for social cooperation, and might therefore be intentionally pursued. Accordingly , the phenomenon of “cumulative stability” (Roberts & Caspi, 2003 ; Roberts & DelVecc hio, 2000 ; Roberts et al., 2008 ) may be an expression of how our pursuit of stability is increasingly effectiv ely realized in adulthood (Greve, 2005 ). But this shifts rather than answers the question: How can the stability of the self (and hence of personal goals) be explained, how does it come about, how do we maintain it—when so much seems to chang e in us and around us? How do we succeed in beha ving and experiencing relative stability in changing environments and as lif e-long changing beings? For this, the reference to defensive mechanisms (o verview: Leary & Tangne y, 2012 ) is obviously not enough, because defensive mechanisms ha ve costs: they f ail to recognize realities that might sometimes be important to take note of. We need to kno w ourselves, especially our limits and weaknesses, perhaps not as precisely as possible, but as precisely as nec- essary, if our plans and actions are not to continually f ail. Even compromising pro- cesses (e.g., “self-immunization”; Greve & W entura, 2003 , 2010 ) are insufficient because the experience of stability is then bought at the price of partial ignorance and decreasing social connectivity. W e should register relev ant physical changes in order to be able to react to them strategically (selective, optimizing, compensat- ing: Freund et al., 1999 ). So we also need self-stabilization processes that accept realities, even unpleasant ones. This is precisely where the accommodativ e mode (Brandtstädter & Greve, 1994 ) comes in: The crucial point here is that accommodat- ing (relative) importance does not imply denying chang e, but merely changing its meaning or value. Hence, one of the major achievements of the processual vie w on human devel- opment is the insight that stability (at a certain level) can be considered a special case of development, not as the opposite; the apparent tension between c hange and Content courtesy of Springer Nature, terms of use apply. Rights reserved. 1 3 Integrative Psychological and Behavioral Science stability can be resolved if attention is paid to which le vel and boundary conditions are in view in each case (V alsiner, 2000 ). At the same time, this allow s for the inte- gration of phenomena such as resilience, which only at first glance signal an alter - native to development (under s tressful conditions), but are actually the name for a (stable) developmental course under certain constellations of conditions (Greve & Staudinger, 2006 ; Leipold & Grev e, 2009 ). This perspective on stability as a developmental phenomenon (outcome) is the condition for the possibility of seriously applying the lifespan perspectiv e to human development, because it ov ercomes (one can say: circumv ents) the objection that adulthood is characterized by a high stability, that ev en tends to increase with age (Roberts & Caspi, 2003 ; Roberts & DelVecc hio, 2000 ; Roberts etal., 2008 ). If sta- bility were the opposite of development, then there would be no de velopment in adulthood, and, thus, a lifespan perspective would be meaningless until v ery old age. If, howev er, stability (on a particular level) is seen as produced by processes on other (i.e.: lower) lev els, if stability occurs through change (“allostasis”; Sterling & Ey er, 1988 ; see also V alsiner, 2000 ), stability becomes an explanandum of developmental theories. At the same time, this view avoids conceptual problems of e xplanations (of behavior or changes) that ref er to stable attributes (traits, competencies, dispositions, etc.; Greve & Kappes, 2017 ). Produced Producer: Regulative Pr ocesses asResult ofandCondition forDevelopment So far, the processual view lea ves open the question of how de velopmental regula- tive processes develop: Ho w and when they emerge and chang e, and why (Greve & Kappes, 2023 ). A number of studies has shown that individuals vary considerably with respect to their preparedness and ability to accommodate their goals or val- ues (Brandtstädter, 2006 ; Brandtstädter & Rothermund, 2002 ; Haase et al., 2013 ; Heckhausen etal., 2010 , 2019 ; Kappes & Gre ve, subm.). The fact that there are indi- vidual differences in the availability of these regulatory and adaptive processes indi- cates that they are dependent on developmental conditions and processes. Although this question remains unresolved f or the time being, it is first important to note that accommodative and other adaptive processes are visible across the lif espan, not only across adulthood (Brandtstädter & Greve, 1994 ; Brandtstädter et al., 1993 ; Heck- hausen etal., 2010 , Heckhausen etal., 2019 ), but also in childhood and adolescence (Lessing etal., 2019 ; Thomsen & Greve, 2013 ; overview: Grev e & Kappes, 2023 ). In this respect, accommodative processes are a plausible candidate for the assump- tion that developmental regulatory processes indeed regulate development across the lifespan. Moreover, the e xample of accommodative dev elopmental regulation can well illustrate how such a process can be both a product and a producer of de velop- ment. In this context, it is helpful to note the distinction between “ontogene tic” and “deferred” adaptations (Bjorklund, 1997 , 2021 ; see next section). It is worthwhile to distinguish between immediate functional forms of coping and regulation, on the one hand, and the developmental processes to be undergone necessarily in childhood Content courtesy of Springer Nature, terms of use apply. Rights reserved. Integrative Psychological and Behavioral Science 1 3 and adolescence to build (the components of) adaptive forms of coping and regula- tion in adulthood, on the other. The examination of immediate (sync hronous) age- related and prospective (diachronous) dev elopmental functionality of the presence and change of a concrete capability will typically onl y allow an adequate explana- tion of the development of a capability such as accommodativ e developmental regu- lation when considered together. Admittedly , the question of which processes regulate the development of the developmental regulatory process under consideration is theoretically complex, because the recognizable danger of a regr essus ad infinitum can only be av oided if it were possible to identify a process (of the second order) that in turn does not require a further regulatory (third order) process for its explanation. It is a central concern of this contribution to sketch such a second-order (at the same time also first-order) process: adaptation. This, howev er, requires a second approach. Adaptation – AnEvolutionary Perspective onExplanation ofDevelopmental Dynamics The second starting point is the insight that, in order to answer the question of why we develop at all (not all or ganisms do: bacteria, for example, do not), and wh y we develop as w e do, an evolutionary perspective is necessary . Like all other phe- nomena invol ving humans (and all other living organisms), the fact of development itself, even more so the structural course of development are products of e volution. Especially human ontogenesis, which on the one hand enters the phase of reproduc- tion extraordinarily late and on the other hand has a very extraordinarily long post- reproductive phase, seems to be in particular need of explanation from an ev olution- ary point of view. Evolutionary Psychology – T he Developmental Gap ofEvolutionary Theory Reiterated Howev er, an evolutionary perspective on psy chology has been a long time coming: It was not until more than a decade after Wilson’ s seminal theses on “sociobiology” ( 1975 ) that the first work on evolutionary psyc hology attracted serious attention (an important step was the edition by Barkow e tal., 1992 ). Meanwhile, there are studies on numerous areas of psychology (e.g., prosocial beha vior: Nowak, 2006 ; antiso- cial behavior: Buss, 2005 ; Daly & Wilson, 1988 ; languag e: Pinker, 1994 ; intelli- gence: Geary, 2005 ; famil y: Salmon & Shackelf ord, 2007 ; personality Buss & Greil- ing, 1999 ), and a number of textbooks and editions have appeared (Badcock, 2000 ; Barrett etal., 2002 ; Buss, 2016 , 2019 ; Crawford & Krebs, 1998 ; Dunbar & Barrett, 2009 ; Gaulin & McBurney, 2004 ; Laland & Bro wn, 2002 ; Palmer & Palmer, 2002 ; Plotkin, 2004 ; Workman & Reader , 2004 ). And there is much to suggest that this evolutionary perspective ma y actually be of help to psychology as a science (Zagaria etal., 2020 ). Content courtesy of Springer Nature, terms of use apply. Rights reserved. 1 3 Integrative Psychological and Behavioral Science Ye t, in some respects the reception of an evolutionary perspective in psychology repeats the history of evolutionary theory in biology (Mayr, 1982 ): a dev elopmental perspective received late and only mar ginal attention. Despite a few earlier precur - sors (Bonner, 1958 ; Gould, 1977 ), only ev olutionary developmental biology (nick - named "Evo-Devo"; Carroll, 2005 ) by the end of the twentie th century has made strong arguments that for ev olutionary dynamics to be effective, not only reliable ontogeny , but precisely dynamic and adaptive individual dev elopment is at any rate useful, perhaps necessary (e.g., Arthur, 2011 ; Hall, 1999 ; West-Eberhard, 2003 ). Likewise, the developmental perspectiv e in psychology has rarely been considered from an evolutionary theoretical perspective (despite earl y pioneers: J.M. Bald- win, 1902 ). Notable exceptions include in particular the seminal work of Bjorklund ( 1997 , 2003 , 2007 , 2016 , 2021 ; Björklund & Green, 1992 ; Bjorklund & Pellegrini, 2002 ; Geary & Björklund, 2000 ), among other contributions (e.g., Burgess & Mac- Donald, 2005 ; Konner, 2010 : for review : Bjorklund et al., 2016 ). The perspective of evolutionary developmental psyc hology has earned the merit not only of point- ing out the fact in the first place that human development, like other human attrib- utes and processes, must be the product of evolution, but also of making con vinc- ingly clear how this insight can be used empirically to better understand human development. Nevertheless, an evolutionary perspective on human de velopment has remained a specialized field. Although some developmental psychology te xtbooks have also now incorporated this perspective (Greve & Bjorklund, 2018 ; b y no means all of them – especially when the life span perspective is f ollowed), and ev olutionary psy- chology handbooks also have a c hapter on development (Buss, 2016 , 2019 ), neither developmental psychology te xtbooks have systematicall y linked the evolutionary perspective to other aspects (of development or human beha vior) nor evolution- ary psychological textbooks refer sys tematically to a developmental point of view (beyond adding it as one important aspect among others). Evolutionary Developmental Psychology: Is aLif espan Perspective Compatible? In particular, the lifespan perspective of dev elopmental psychology has very rarely been linked to an evolutionary perspective (Gre ve & Bjorklund, 2009 ; see also Bogin, 1997 ; Bogin & Smith, 1996 ). Rather, work on evolutionary dev elopmental psychology has focused almost e xclusively on the first decade of lif e (Bjorklund, 2021 ; Bjorklund & Ellis, 2014 ). Although evolutionary theory formulated the ques- tion of an explanation of postreproductive old ag e early on (e.g., Austad, 1997 ; Carey & Judge, 2001 ), and anthropology has discussed, for e xample, the role of grandparents in reproduction in a number of studies (Hawkes, 2004 ; V oland etal., 2005 ), the viewpoint of age has hardly been discussed from an ev olutionary perspec- tive in developmental psyc hology (Greve & Bjorklund, 2009 ). In fact, at leas t at first glance, the life span perspective does not seem to fit with an ev olutionary perspec- tive: already the phenomenon of aging itself, but even more so a sy stematic structure of aging, can hardly be explained, it seems, f or a life stage in which reproduction Content courtesy of Springer Nature, terms of use apply. Rights reserved. Integrative Psychological and Behavioral Science 1 3 has already taken place: “The benefits resulting from evolutionary selection evince a negative age correlation” (Baltes, 1997 , p. 367). There are, howev er, god reasons for the compatibility of an ev olutionary perspec- tive with a lifespan perspective (Gr eve & Bjorklund, 2009 ), in particular also for a compatibility with stabilizing processes in general and accommodative processes in particular (Greve & Thomsen, 2016 ; Greve e t al., 2014 ). If the functionality of older and old members of a community is to use the accumulated and integrated experiences of a (long) life to improv e the survival and reproductive prospects of the younger members of the group (Diamond, 2001 ; Mergler & Goldstein, 1983 )), then this requires not only communicative skills and transgenerational inter ac- tions (Kessler & Staudinger, 2007 ; V oland etal., 2005 ), also not only the ability to memorize (Mergler & Goldstein, 1983 ) and remember especially older experiences (Rubin et al., 1986 ), but also the ability to integrate single or regular experiences into a cognitive network that allo ws to give advice also for new, at best structurally comparable cases and constellations. Wisdom (defined as a well-balanced coordina- tion of emotions, motivation, and thought, with good judgement and the ability to offer advice in difficult and uncertain matters of life; Staudinger & Dörner, 2006 ) should prove an important resource of the elderly (e.g., Baltes & Staudinger , 2000 ; Staudinger, 1999 ). Wisdom, and its usage for younger generations, in turn, appar- ently presupposes stability of numerous mental functions—from cognitive capaci- ties to integrative functions of self and personality (such as processes of self-esteem maintenance). It is for this function that the processes of stabilization mentioned above are relev ant, presumably necessary, especially in late adulthood and old age (Greve & Bjorklund, 2009 ). Adaptation: From Phylogen y toOntogeny Howev er, even the extension of the e volutionary perspective to the whole life span (in particular, as mentioned above, the older age) does not use the theoretical poten- tial of the evolutionary theory sufficiently . The special point of evolutionary theory is its abstraction. The process of adaptation (channeled through history, whic h docu- ments and reflects the contingent factual course of the preceding phylog enesis) is the conceptual core of the theory (Gould, 2002 ; Maynard Smith, 1958 ). Note that this theoretical core is not dependent on concrete (physiological or biochemical) realiza- tion: Remarkably , Darwin’s conception of ho w heredity works was entirel y wrong, and remarkably , the concrete mechanism of organic heredity is entirely indiffer - ent to the soundness of his theory. Y et the systematic application of the theoretical core of evolutionary theory – adaptation and history (Greve & Kappes, 2017 ) – to human ontogeny is still pending (f or exceptions, see Lickliter & Hone ycutt, 2003 ; Siegler, 1996 ). This concerns in particular the central concept of adaptation (“selec- tive retention of fitness-enhancing variants”; Campbell, 1960 , 1969 )—and thus the concepts of selection, retention, fitness, and variation entailed by it. Why is adaptation more than a prototypical example f or an application of evolu- tionary concepts on human development? The main idea of this plea is that adapta- tion is a process that is also self-explanatory—at least that does not in turn require Content courtesy of Springer Nature, terms of use apply. Rights reserved. 1 3 Integrative Psychological and Behavioral Science another process to explain it, thus av oiding infinite regress. One important line of reasoning leading to this argument is the consideration that adaptability, which v ar- ies between species, is itself a product of ev olutionary and thus adaptive processes (e.g., Lasker, 1969 ; Moran, 2008 ; W agner, 2005 ; W agner & Altenberg, 1996 ). The analogous application of this idea to human development leads to an explanation of individual differences in adaptability – and thus back to individual differences with respect to adaptive regulatory processes (e.g., accommodation). Accordingly , if individual adaptivity (both ontogenetical and micro-processual) is a core of (human) development, if adaptivity has dev eloped throughout our phy- logeny (i.e. ev olution), and if both levels (“dimensions”) of dev elopment (phylogeny and ontogeny) proceed according to the very same principles (selective retention of fitness-enhancing variants), then individual development could be view ed as adapta- tion to “tasks” or “problems” or “crises”, and the ontogenetical development of indi- vidual adaptivity should follow these (adaptive) principles as well. A ccording to this idea, adaptation would be, at the same time, process and product of development (on phylogenetical, ontog enetical and microprocessual layers). One implication of this perspective is the assumption that development, like evolution, is stimulized or ev en forced by problems. If adaptivity is a de velopmen- tal result of a variety of reactions to challenges, then individual adaptivity should benefit from a variety (heterogeneity) of challeng es (problems, tasks, crises). There is some first evidence that heterogeneous lif e circumstances actually support (at least predict) individual adaptivity (here: individual preparedness and capability of goalaccommodation). For instance, Greve and Thomsen ( 2013 ; Thomsen & Greve, 2013 ) found in two studies that heterog eneous leisure activities in childhood predict flexibility of goal adjustment in adolescence, and Greve e tal. ( 2021 ) found that mul- tilingualism in childhood predicts flexibility of goal adjustment in adulthood. Adaptation: Theoretical Challenges The recursive ("self-explanatory") potential of the concept of adaptation addressed above is demonstrated b y the fact that adaptation could (help) explain how differ- ences in adaptivity arise. In a study of a group of genetically identical mice (Freund etal., 2013 ) raised in a large and heterog eneous cage environment, it was sho wn that initially random behavioral v ariations between individual mice self-sustained into differential behavioral dispositions that led to increasingly distinct differences in how they used the (potentially) heterog eneous cage environment. The differences in explorativeness (and thus heterogeneity of de velopmental stimulation) in turn then led to measurable developmental differences (in this study , brain structures). The unsystematic variation, which is at the beginning of the explanation, then leads to different manifest dev elopmental trajectories via the different effects that the varying behavior has on the behaving individual. It is precisel y this process that the concept of adaptation describes. Thus, the central concern of the theoretical application of evolution in general and adaptation in particular is to investigate to what extent the dynamics (selection), consistency (retention), and individuality (variation) of human development can be Content courtesy of Springer Nature, terms of use apply. Rights reserved. Integrative Psychological and Behavioral Science 1 3 described in a theoretically integrative wa y with the help of these concepts (among some others). To this end, several theoretical pr oblems need to be discussed, includ- ing (i) the more precise conceptualization of adaptation (selection, variation, reten- tion, fitness), (ii) the question of what other evolutionary concepts can or must be considered for a theoretical perspective on human de velopment, and (iii) the ques- tion of the unit of (evolutionary)selection. (i) Evolutionary theory has admittedly struggled with the centrality of the con - cept of adaptation since the seminal critique of Gould and Lewontin ( 1978 ). Actually , there are several competing conceptualizations (e.g., Andrew s etal., 2003 ; Buller, 2005 ; Buss etal., 1998 ; Orzack & Sober , 2001 ; Reeve & Sher - man, 1993 ; Rose & Lauder, 1996 ; W illiams, 1966 ), in particular with respect to the question of whether everything we can observe at a giv en point in time in terms of distinctive (at least widespread) attributes is an adaptation (func - tional with respect to the given circumstances: Fisher, 1930 ; Ree ve & Sher - man, 1993 ), or the result of an adaptation (functional with respect to former circumstances: Sterelny & Griffiths, 1999 ), or both (Grafen, 1982 ; Williams, 1966 ). Of course, numerous approaches have considered human behavior as adapta - tion (e.g., Cronk etal., 2000 ). What needs to be clarified, therefore, is a viable notion of adaptation that can also be connectable in psychology: there are countless examples of a merely metaphorical use of the notion of adaptation, especially in psychology . Adaptation is now ubiquit ous in numerous areas of psychology , not just in various strands of evolutionary psychology (Bar kow etal., 1992 ; Bjorklund & Ellis, 2005; Buss e tal., 1998 ), but in numerous other fields, such as emotion regulation (Lazarus, 1991 ), coping theories (Taylor , 1983 ; V aillant, 1977 ; Wrosch etal., 2003a , b ), personality approaches (Buss & Greiling, 1999 ), rationality theories (Gigerenzer, 2000 ), cognitive processes (Anderson, 1991 ), and, of course, human development (e.g., Baltes, 1997 ; Greve etal., 2005 ; Piaget, 1978 , 1980 ). If we are to ov ercome a mere meta - phorical (loose) usage of the concept of adaptation, we are badly in need of of conceptual clarification. (ii) Certainly, evolution must no t be reduced to adaptation (this is a central tenet of the discussion from Gould & Lewontin ’s, 1978 , plea on ward). If adaptation is an important, but not an exclusive concept of an ev olutionary perspective, the extent to which other ev olutionary processes (such as drift; Brandon, 2006 ; Futuyama, 1998 ) can be applied to human development must be examined. Although this task is still to be solved, its necessity will probably pro ve to be a theoretical advantage: the burden of explaining human dev elopment would have become too hea vy for just one concept (adaptation). (iii) Psychology—and dev elopmental psychology in particular—focuses on indi - viduals. But if evolution (according to widely held vie ws; e.g., Futuyma, 1998 ; Gould, 2002 ; Maynard Smith, 1958 ; Ma yr, 2001 ) focuses on populations – can evolution (and adaptation) be applied in a more than metaphorical sense to ontogeny of persons? Bey ond a serious recognition of the “unit of selection” problem (e.g., Gould & Lloyd, 1999 ), any affirmative answer mak es an impor - Content courtesy of Springer Nature, terms of use apply. Rights reserved. 1 3 Integrative Psychological and Behavioral Science tant assumption that needs to be discussed in more detail: The thesis that the relevant unit of dev elopment (whether ontogenetic or phylogene tic) is devel - opmental systems. Remarkably , although this approach was first f ormulated in evolutionary theory (Griffith & Gray, 2004 ; Oyama, 1985 ), it w as taken up very early (and quite independently of an e volutionary perspective) in devel - opmental psychology (Ford & Lerner, 1992 ; Thelen & Smith, 1994 ). It is still not central there either (many textbooks do not deal with the topic or only in passing), but it has been discussed in more detail in theoretical volumes for some time (Overton & Molenaar, 2015 ). If this approach can be de fended, that is, if there is evolution (dev elopment) at multiple levels (Jablonka & Lamb, 2005 ; Sober & Wilson, 1998 ), then the idea that the same (not just similar) processes are operative at all lev els is no longer implausible. If humans are developmental systems (and parts of dev elopmental systems, and consist of developmental systems), and if their dev elopment could be recon- structed—and thus: explained—in evolutionary terms, then it must be taken into account that systems do not only change linear ly, but typicall y dynamically and in a complex wa y. Although the concept of dynamic systems (Feldman, 2019 ) w as taken up early in developmental psy chology (Thelen & Smith, 1994 ), it has so far only been taken up in relatively specialized (methodological) discussions (e.g., Boker & Weng er, 2008 ; see Overton & Molenaar, 2015 ); although it is hardly doubted on the merits, it has so far only been possible to apply it empirically , to developmen- tal topics in narrowly defined fields (e.g., Lenzing etal., 2023 ). Here, t he crucial challenge of the coming years will be to make suc h methodological (mathematical) approaches empirically useful in developmental psy chology. The comple x systems approach, which takes another significant step f orward here (Mitchell, 2009 ), is even less frequently discussed—although it is recognizably w orthy of attention. It is the plan of this chapter to contour the opportunities and challenges inherent in such an extension. It will be particularly fruitful not only , but especially, if it w ere viable to describe human ontogenesis in evolutionary terms, i.e., self-regulated. Conclusion The resulting view on human development w ould then not only be a serious life span approach, but at the same time a biological approach, which w ould not be confined to a specific physical realization (i.e., would not ha ve to presuppose certain assump- tions about, for example, g enetic or neurological processes). It is precisely the theo- retical application of the adaptation concept that allows for a s tructural and proces- sual understanding of development that is at the same time universal and not onl y takes individuality into account but also explains it. This view might be called “indi- vidual evolution”. Among the theoretical challenges of suc h an approach will be the defense of a non-reductionist psychology that takes biological pr ocesses seriously without reducing psychology to physiology . Central in this context is the thesis that the special potential of the theory of evolution lies in the abstract theory, not (only) in the precise physiological description of the way humans are f actually realized (the Content courtesy of Springer Nature, terms of use apply. Rights reserved. Integrative Psychological and Behavioral Science 1 3 theory of evolution has gained in plausibility since 1859, although Darwin’ s idea of how heredity is realized in humans and other animals was entirel y incorrect). In order to apply the concept of adaptation to human ontogeny in this theoretical and abstract manner (and not just use it metaphorically as an illustration), the ques- tion must be answered how inf ormation transfer (which in phylogene tic evolution in the sense of inheritance is one of the conditions of adaptation and thus evolution) can be thought of intraindividually, especiall y in a way that simultaneously ensures both variation and retention. Since the mid-twentieth century, ev olutionary theory has very largely settled on the idea that in ev olutionary dynamics this transgenera- tional transfer of information (including a sufficiently small but at the same time sufficiently large amount of unsystematic variation) is realized via genes encoded in DNA that is retained and used in the cells of all living organisms. The application of the adaptation concept to other (i.e., individual) developmental dynamics implies a comparably functional realization of horizontal (learning) and vertical (inheritance) information transfer . It is perhaps the most difficult challenge for the en visioned application of adap- tation to human ontogeny that such a concept of transf er of information must be defended against the numerous and serious criticisms that several approaches to applying evolutionary theory to non-biological entities (especially culture: Boyd & Richerson, 2005 ; Distin, 2011 ) have been subjected to. Prototypical of this discus- sion is the ambitious concept of “memes” (originally proposed by Dawkins, 1976 ; see Aunger, 2000 ; Blac kmore, 1999 ; Distin, 2005 ), which (although the term has endured) has so far failed to pro ve scientifically fruitful. To prepare a future solu- tion, it will be certainly necessary to apply some aspects of modern information the- ory (for a smart introduction: Gleick, 2011 ) to psychological content. The quest for such an integrativ e application and perspective, howev er, might be worth the effort. The promise of this application of adaptation to human devel- opment could be (1) an integration of productive theories of human development (e.g., Piaget, Erikson, Havighurst, Bow lby , Marcia), (2) an integration of vari- ous approaches from a lifespan perspectiv e (Baltes, 1997 ; Baltes & Baltes, 1990 ; Brandtstädter, 2006 ; Brandtstädter & Rothermund, 2002 ; Heckhausen et al., 2010 , 2019 ; Ford & Lerner, 1992 ; Thelen & Smith, 1994 , to name a few), (3) a conceptual framework f or current issues (e.g., resilience; Greve & Staudinger, 2006 ; Leipold & Greve, 2009 ), (4) an integration of both micro-processes and macro-processes of change (Coping, Learning) into one concept of development, (5) the final extinction of intellectual zombies (e.g., a fruitless „nature-nurture “ dichotomy), and (6) the adoption of a conceptual evolutionary psychology perspectiv e without using non- plausible assumptions of evolutionary psychology (suc h as the „massive modularity hypothesis “; Buller, 2005 ). An evolutionary perspective on human dev elopment might pave the wa y not only to understand why we dev elop in the first place, and not only to better understand the current and postponed functionality of different developmental steps, but also to be able to explain how dev elopment happens, how it is controlled. W e do need the- ory in (developmental) psychology (“No science can be ‘empirical’ only”; V alsiner, 2000 , p. 2). That is why it is worth looking for an abstract and integrative theory of development. Content courtesy of Springer Nature, terms of use apply. Rights reserved. 1 3 Integrative Psychological and Behavioral Science Acknowledgements The arguments outlined in this paper have been discussed over decades with many colleagues and friends. For innumerable insights, objections, suggestions, hints and ideas I am particu- larly indebted to David Bjorklund, Alex andra Freund, Cathleen Kappes, Ulman Lindenberger, Bernhard Leipold, Claudia Mähler, Klaus Rothermund, Farina Rühs, Petra Sandhagen, Ursula Stauding er, Tamara Thomsen and Dirk Wentura, among sev eral others. The gratitude that I owe to my mentors Jochen Brandtstädter and Günter Krampen can never be repaid – I shall remember and honor their inspiration and the attitude of scientific seriousness they taught me across my lifespan. Author contributions W .G. wrote the entire text of this manuscript. Funding Open Access funding enabled and organized by Projekt DEAL. Declarations Competing interests The authors declare no competing interests. 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Of course, the examples are very superficially presented; yet what they mean to convey, is that a sociocultural developmental view, supported by an open dynamic approach enables us, via concepts such as rupture, transition and dynamic patterns, to account for variations in adaptivity and sense-making, and for the emergence of newness in people's personal engagements. Greve (2023) proposes a diagnostic of the current fragmentation of developmental psychology, and a cure, to recur to evolutionary psychology. With many others, I tend to concur with the diagnostic; but I believe that the response overlooks alternative attempts to overcome the crises. ... Integrative Perspectives on Human Development: Dynamic and Semiotic INTEGR PSYCHOL BEHAV Tania Zittoun Werner Greve argues for an abstract and integrative theory of development; to progress toward such a theory, he suggests that evolutionary psychology can provide concepts for a processual approach to adaptation. To complement this perspective, I propose to start where the author finishes: the need to further qualify change, and to account for information. Considering ruptures and sense-making as cornerstones of a developmental approach, I recall that open dynamic approaches offer a meta-theoretical frame for an integrative developmental psychology, and that cultural approaches already and always account for meaning-making to start with. Assuming these two givens, a variety of integrative propositions account for stability and change; I present an historical example, the work of Gordon Allport, and a current one, our work as sociocultural psychologists, to show how the theoretical and heuristic interest of this proposition.
https://www.researchgate.net/publication/370261966_Adaptation_across_the_Lifespan_Towards_a_Processual_Evolutionary_Explanation_of_Human_Development
DOMINGO PADUA v. VICENTE ERICTA GR No. L-38570, (1988-05-24) Show opinions DIVISION [ GR No. L-38570, May 24, 1988 ] DOMINGO PADUA v. VICENTE ERICTA + DECISION 244 Phil. 479 FIRST DIVISION [ G.R. No. L-38570, May 24, 1988 ] DOMINGO PADUA,PETITIONER, VS. HON. VICENTE ERICTA, ETC., RUNDIO ABJAETO, AND ANTONIO G. RAMOS, RESPONDENTS. D E C I S I O N NARVASA, J.: Courts should not brook undue delays in the ventilation and determination of causes. It should be their constant effort to assure that litigations are prosecuted and resolved with dispatch. Postponements of trials and hearings should not be allowed except on meritorious grounds; and the grant or refusal thereof rests entirely in the sound discretion of the Judge. It goes without saying, however, that discretion must be reasonably and wisely exercised, in the light of the attendant circumstances. Some reasonable deferment of the proceedings may be allowed or tolerated to the end that cases may be adjudged only after full and free presentation of evidence by .all the parties, specially where the deferment would cause no substantial prejudice to any part. The desideratum of a speedy disposition of cases should not, if at all possible, result in the precipitate loss of a party s right to present evidence and either in plaintiff's being non-suited or the defendant's being pronounced liable under an ex parte judgment. "*** (T)rial courts have *** the duty to dispose of controversies after trial on the merits whenever possible. It is deemed an abuse of discretion for them, on their own motion, "to enter a dismissal which is not warranted by the circumstances of the case' (Municipality of Dingras v. Bonoan, 85 Phil. 458-59 [1950]). While it is true that the dismissal of an action on grounds specified under Section 3, Rule 17 of the Revised Rules of Court is addressed to their discretion ( Flores v. Phil. Alien Property Administrator, 107 Phil. 778 [I960]; Montelibano v. Benares. 103 Phil. 110 [1958]; Adorable v. Bonifacio, 105 Phil. 1269 [1959]; Inter-Island Gas Service, Inc. v. De la Gerna, L-17631, October 19, 1966, 18 SCRA 390), such discretion must be exercised soundly with a view to the circumstances surrounding each particular case ( Vernus-Sanciangco v. Sanciangco, L-12619, April 28, 1962, 4 SCRA 1209). If facts obtain that serve as mitigating circumstances for the delay, the same should be considered and dismissal denied or set aside ( Rudd v. Rogerson, 15 ALR 2d 672; Cervi v. Greenwood. 147 Colo 190, 362 P. 2d 1050 [1961]), especially where the suit appears to be meritorious and the plaintiff was not culpably negligent and no injury results to defendant (27 C.J.S. 235-36; 15! ALR 3rd680)." ( Abinales vs. Court of First Instance of Zamboanga City, Br. I, 70 SCRA 590, 595). "It is true that the allowance or denial of petitions for postponement and the setting aside of orders previously issued, rest principally upon the sound discretion of the judge to whom they are addressed, but a ways predicated on the consideration that more than the mere convenience of the courts or of the parties of the case, the ends of justice and fairness would be served thereby ( Camara Vda. de Zubiri v. Zubiri, et al., L-16745, December 17, 1966). When no substantial rights are affected and the intention to delay is not manifest, the corresponding motion to transfer the hearing having been filed accordingly, it is sound judicial discretion to allow them ( Rexwell Corp. v. Canlas, L-16746, December 30, 1961)." ( Panganiban vs. Vda. de Sta. Maria, 22 SCRA 708, 712). In the civil action at bar, the Trial Court rejected the plaintiff's plea for cancellation of one of three (3) hearing dates, the very first such plea made by that party, upon a ground not entirely unmeritorious in the premises, and under such circumstances as would not be productive of any appreciable delay in the proceedings or any substantial prejudice to the defendants, and summarily dismissed the complaint. Such a dismissal was unwarranted and relief therefrom must be accorded. The action that was thus summarily dismissed had been brought by Domingo Padua (petitioner herein) in the Court of First Instance at Quezon City. [1] In that action Padua sought to recover damages for the injuries suffered by his eight-year old daughter, Luzviminda, caused by her being hit by a truck driven by Rundio Abjaeto and owned by Antonio G. Ramos (private respondents herein). Padua was litigating in forma pauperis. Trial of the case having been set in due course, Padua commenced presentation of his evidence on December 6, 1973. He gave testimony on direct examination in the course of which reference was made to numerous documents, marked Exhibits B, B-l to B-109. [2] At the close of his examination, and on motion of defendants' counsel, the previously scheduled hearing of December 12,1973 was cancelled, and Padua's cross-examination was reset on December 17, 1973. [3] However, the hearing of December 17, 1973 was also cancelled, again at the instance of defendants' counsel, who pleaded sickness as ground therefor; and trial was once more slated to "take place on March 6, March 7 and 13, 1974, all at 9:00 o'clock in the morning." [4] After defendants' attorney had twice sought and obtained cancellation of trial settings, as above narrated, it was plaintiff Padua's counsel who next moved for cancellation of a hearing date. In a motion dated and filed on March 1, 1974, [5] copy of which was personally served on defendants' lawyer, [6] Padua's counsel alleged that he had "another hearing on March 6, 1974 in Tarlac Court of First Instance entitled: Salud Dupitas vs. Mariano Abella, Civil Case No. 4904 which is of 1966 stint, and said court in Tarlac is anxious to terminate said case once and for all," and that the cancellation would "at any rate *** leave plaintiff and defendants two (2) hearing dates on March 7and 13, 1974;" and on these premises, he asked "that the hearing on March 6, 1974 *** be ordered cancelled." No opposition was filed by the defendants to the motion, whether on the ground that the motion had not been properly set for hearing, the clerk having merely been requested to "submit the *** motion upon receipt *** for the consideration of the Court," [7] or some other ground. Apart from filing this motion on March 1, 1974, plaintiff's counsel took the additional step of sending his client's wife to the Court on the day of the trial, March 6, 1974, to verbally reiterate his application for cancellation of the hearing on that day. This, Mrs. Padua did. The respondent Judge however denied the application and dismissed the case. His Honor's Order, dictated on that day, March 6, 1974, reads as follows: [8] "When this case was called for hearing today, neither plaintiff nor counsel appeared. The plaintiff's wife, however, appeared in Court and informed the Court that the plaintiffs counsel had to attend to a very important case in the provinces. "The hearing for today was fixed by the plaintiff himself in open court after consulting his calendar and hence the Court will not grant the postponement on the ground that the plaintiff's counsel had a very important case in the provinces. Neither did the plaintiff himself appear. "In view hereof, let this case be dismissed. Padua moved for reconsideration, [9] but this was denied. [10] Hence, this petition. The Trial Court unaccountably ignored the fact that defendants' counsel had twice applied for and been granted postponements of the trial; that plaintiff's counsel had filed a written motion for postponement five (5) days prior to the hearing sought to be transferred, and this was the very first such motion filed by him; that although the motion for postponement could have been objected to, no opposition was presented by defendants, which was not surprising considering that their counsel had himself already obtained two (2) postponements; that the ground for cancellation was not entirely without merit: the counsel had a case in the Tarlac Court scheduled on the same day, March 6, 1974, which had been pending since 1964 and which the Tarlac Court understandably was anxious to terminate; that the Padua motion for postponement sought cancellation of only one (1) of three settings, leaving the case to proceed on the two (2) subsequent hearing dates; and the motion had been verbally reiterated by plaintiff's wife on the day of the hearing sought to be cancelled. Under the circumstances, and in the light of the precedents set out in the opening paragraphs of this opinion, the respondent Judge's action was unreasonable, capricious and oppressive, and should be as it is hereby annulled. WHEREFORE, the writ of certiorari is granted and the Order of the Court a quo dated March 6, 1974, dismissing the petitioner's complaint, and the Order dated March 13, 1974 denying petitioner's motion for reconsideration, are hereby ANNULLED AND SET ASIDE; Civil Case No. Q-17563 is hereby REINSTATED and the Regional Trial Court which has replaced Branch XVIII of the Court of First Instance in which the action was pending at the time of dismissal, is DIRECTED to continue with the trial of the petitioner's action and decide the same on the merits in due course. SO ORDERED. Cruz, Gancayco, Griño-Aquino, and Medialdea, JJ., concur. [1] Docketed as Civil Case No. Q-1 7563, and assigned to Branch XVII then presided over by Hon. Judge Vicente Ericta. [2] Rollo, p. 15. [3] Par. 8. petition. [4] Par. 9. petition. [5] Annex F. petition. [6] Rollo. p. 17. [7] This was. of course, a violation of Sections 4 and 5. Rule 1 5 of the Rules of Court. [8] Par. 11, petition. [9] Rollo, pp. 18-19. [10] Id., p. 20. tags
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Meibomian Gland Dysfunction: Recent Progress Worldwide and in Japan | IOVS | ARVO Journals Meibomian Gland Dysfunction: Recent Progress Worldwide and in Japan Shiro Amano Author Affiliations & Notes Shiro Amano Inouye Eye Hospital, Tokyo, Japan Correspondence: Shiro Amano, Inouye Eye Hospital, 4-3 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan; [email protected] . Investigative Ophthalmology & Visual Science November 2018, Vol.59, DES87-DES93. doi: https://doi.org/10.1167/iovs.17-23553 Abstract In this review, the importance of Japanese research on meibomian gland dysfunction (MGD) is discussed from the perspective of global academic and clinical research on this topic. Many Japanese physicians and researchers have contributed to recent worldwide progress in various fields of MGD research, including pathophysiology, epidemiology, diagnosis, and therapy. In Japan, recent studies in the field of pathophysiology have provided direct evidence for the hypothesis that lipid composition and reactive oxygen species play a crucial role in the development and worsening of MGD. In the field of diagnosis, slit-lamp examination, in vivo confocal microscopy, and meibography have been widely used in studies from Japan. On the basis of the results of these studies, the MGD working group in Japan has proposed new diagnostic criteria for obstructive MGD. According to these criteria, obstructive MGD is considered present when ocular symptoms, anatomic abnormalities, and meibomian gland obstruction are present. In the field of therapy, devices and drugs newly developed in Japan have been shown to enhance the efficacy of lid hygiene and warm compression. Moreover, diquafosol and vitamin D3 have been shown to be effective for MGD. In conclusion, standardization of the diagnosis and treatment of MGD is necessary to enable all patients with MGD to receive appropriate treatment, and specific diagnostic criteria with cutoff values for each parameter are necessary to standardize the diagnosis of MGD. The term meibomian gland dysfunction (MGD) was coined by Korb and Henriquez in 1980, 1 although investigators were already studying, and continue to study, MGD. In 2011, the International Workshop on MGD compiled a comprehensive overview of various aspects of MGD, including the definition, classification, prevalence, risk factors, structure of meibomian gland lipids, diagnosis, and treatment. The International Workshop on MGD defined MGD as follows: “A chronic, diffuse abnormality of the meibomian glands, commonly characterized by terminal duct obstruction and/or qualitative/quantitative changes in the glandular secretion. It may result in alteration of the tear film, symptoms of eye irritation, clinically apparent inflammation, and ocular surface disease.” 2 Moving away from this definition of MGD, the present review article describes recent progress and future directions in MGD research. Many Japanese researchers have contributed to recent progress in various fields of MGD research, including pathophysiology, epidemiology, diagnosis, and therapy. There is no large disagreement between researchers in Japan and those in other countries with regard to the pathophysiology, epidemiology, diagnosis, and therapy of MGD. Rather, the studies conducted by Japanese physicians and researchers have contributed to the core of knowledge concerning MGD. Pathophysiology A recent important finding in the field of MGD-related pathophysiology was the role of ectodysplasin A from the meibomian glands in the regulation of the corneal epithelial barrier function. Sanming Li's 3 group showed that ectodysplasin A is highly expressed in meibomian glands and is detected in human tears. They also showed that ectodysplasin A promotes corneal epithelial cell proliferation through regulation of the epithelial growth factor receptor signaling pathway, thereby playing an essential role in the maintenance of corneal epithelial homeostasis. Arita et al. 4 examined the relationship between the composition of free fatty acids (FFAs) in meibum and clinical parameters in patients with MGD and healthy controls and found that unsaturated FFAs tend to be more abundant in colored meibum. In another study, they reported that the relative amount of linoleic acid in meibum is associated with the severity of telangiectasia and plugging of gland orifices in patients with MGD. 5 In an animal study, Miyake et al. 6 reported that MGD developed in hairless mice fed a special diet with limited lipid content. In this mouse model, findings characteristic to MGD, such as plugging of the meibomian gland orifices, telangiectasia, and toothpaste-like meibum, were observed ( Fig. ). Histopathologically, hyperkeratinization of the ductal epithelium in the meibomian gland was observed. Loss of acini and atrophy of the glands were also observed. These findings were similar to those in patients with MGD. In addition, in this model, azithromycin treatment decreased the number of plugged orifices. It was suggested that the deficiency of n-6 polyunsaturated fatty acids, particularly linoleic acid, plays an important role in the development of MGD. These recent studies provided direct evidence for the hypothesis that alterations in the lipid composition play a crucial role in the development and worsening of MGD. However, the factors affecting the composition of lipids in meibum remain unknown. One strong candidate factor is oxidative stress. Ibrahim et al. 7 investigated alterations in the meibomian glands in Cu, Zu-superoxide dismutase-1 knockout mice and found an accumulation of large lipid droplets and increased terminal deoxynucleotidyl transferase dUTP nick-end labeling and oxidative stress marker staining in the meibomian gland acinar epithelium, suggesting a pivotal role of reactive oxygen species in the pathogenesis of MGD. Figure The eyelids of mice fed a normal diet ( A , B ) and a special diet with limited lipid content (the HR-AD diet) ( C , D , E ) for 11 weeks, from 5 to 16 weeks of age. Rounding ( C ), plugging and telangiectasia ( D , arrowheads ), and toothpaste-like meibum ( E , arrowheads ) can be seen. This figure was extracted from Miyake H, Oda T, Katsuta O, Seno M, Nakamura M. Meibomian gland dysfunction model in hairless mice fed a special diet with limited lipid content. Invest Ophthalmol Vis Sci . 2016;57:3268–3275, with permission from the Association for Research in Vision and Ophthalmology. Figure The eyelids of mice fed a normal diet ( A , B ) and a special diet with limited lipid content (the HR-AD diet) ( C , D , E ) for 11 weeks, from 5 to 16 weeks of age. Rounding ( C ), plugging and telangiectasia ( D , arrowheads ), and toothpaste-like meibum ( E , arrowheads ) can be seen. This figure was extracted from Miyake H, Oda T, Katsuta O, Seno M, Nakamura M. Meibomian gland dysfunction model in hairless mice fed a special diet with limited lipid content. Invest Ophthalmol Vis Sci . 2016;57:3268–3275, with permission from the Association for Research in Vision and Ophthalmology. Diagnosis The diagnosis subcommittee of the International Workshop on MGD recommended the following tests for the diagnosis of MGD-related disease in the general clinical setting: symptom questionnaire, blink rate, tear meniscus height, tear osmolality (if available), tear breakup time, fluorescein staining, Schirmer test, slit-lamp findings (lid changes, meibum expressibility/quality), and meibography. 8 These tests enable physicians to differentiate dry eye from normal eyes and MGD-related evaporative dry eye from aqueous-deficient dry eye. In that report, however, specific diagnostic criteria for MGD were not proposed, which would be necessary to standardize the diagnosis. LipiView More recently, the LipiView interferometer (TearScience, Inc., Morrisville, NC, USA) was introduced as a new tool for MGD diagnosis. LipiView provides values for the tear film lipid layer thickness (LLT). Finis et al. 9 reported that the sensitivity and specificity for MGD diagnosis were 65.8% and 63.4%, respectively, when the LLT cutoff value was ≤75 nm, and 47.9% and 90.2%, respectively, when the LLT cutoff value was ≤60 nm. These values were not high enough for clinical use, but they could be enhanced when the LLT value was combined with other parameters such as symptom scores, lid margin abnormality score, and meibography score. Jung et al. 10 investigated the factors related to LLT and found that age, female sex, hypersecretory MGD, and lid margin inflammation are associated with increased LLT. Slit-Lamp Examination Findings around the meibomian gland orifices, such as plugging, telangiectasia, and lid margin irregularity, are crucial for the diagnosis of MGD. However, interrater disagreement on the grading of these findings may exist. Arita et al. 11 developed new grading scales for MGD signs that were based on many photos of lids in patients with MGD and healthy controls. Vascularity, plugging of gland orifices, and partial glands were assessed on a scale from 0 to 3, and lid margin irregularity, lid margin thickening, and gland dropout were assessed on a scale from 0 to 2. A validation test was performed in another set of patients with MGD to evaluate the efficacy of the proposed grading scales, and the new grading scales showed appropriate inter- and intrarater reliabilities for grading MGD. This suggested the suitability of the grading scales for the standardization of slit-lamp findings in MGD patients. In Vivo Confocal Microscopy The usefulness of both microscopic (in vivo confocal microscopy) and macroscopic (meibography) methods for MGD diagnosis has been reported in Japan. The details of research using in vivo confocal microscopy in Japan are described in another article in this issue. Briefly, Ibrahim et al. 12 measured four confocal microscopic parameters in patients with MGD and healthy controls: meibomian gland acinar longest diameter, meibomian gland acinar shortest diameter, inflammatory cell density, and meibomian gland acinar unit density. These parameters showed a strong and significant correlation with tear function, ocular surface vital staining, meibomian gland expressibility, and meibomian gland dropout grades. All parameters showed high sensitivity and specificity for MGD diagnosis, suggesting the potential of in vivo confocal microscopy. Moreover, Matsumoto et al. 13 used in vivo confocal microscopy to evaluate the anti-inflammatory treatment response in patients with MGD. Inflammatory cell density was significantly reduced, suggesting that inflammatory cell density is a new parameter for evaluation of the treatment response. Ibrahim et al. 14 also used in vivo confocal microscopy to evaluate meibomian gland alterations in patients with atopic keratoconjunctivitis, and the averages of the four parameters were significantly worse for patients with atopic keratoconjunctivitis than for patients with obstructive MGD and normal controls. This result shows that changes in meibomian glands are more severe in patients with atopic keratoconjunctivitis than in patients with obstructive MGD. Meibography In addition to the microscopic method (confocal microscopy), a macroscopic method known as noncontact infrared meibography has been developed in Japan for the observation of changes in the meibomian glands. The details of studies performed using noncontact infrared meibography in Japan are described in another article in this issue. Briefly, meibography can be used to obtain information about the morphologic characteristics of meibomian glands. Although meibography was developed three decades ago, it is not widely used because of patient discomfort and a long examination time. In contrast, the newly developed meibography technique is a noncontact and less time-consuming method that uses an infrared filter and infrared charge-coupled device video camera. Using noncontact meibography, Arita et al. revealed meibomian gland loss associated with aging, 15 contact lens wear, 16 and long-term topical antiglaucoma medications. 17 , 18 Diagnostic Criteria Diagnostic criteria are essential for MGD detection. Thus far, various groups worldwide have used different diagnostic criteria, which makes comparisons of MGD studies difficult. Arita et al. 19 compared the scores for clinical findings, including ocular symptoms, lid margin abnormalities, meibography findings, meibum, superficial punctate keratopathy, and tear film production, between patients with obstructive MGD and normal controls to propose diagnostic criteria for obstructive MGD. The area under the receiver operating characteristic curves indicated that the ocular symptom score had the highest diagnostic power, followed by the lid margin abnormality score, meiboscore, and tear breakup time. On the basis of these findings and other results, the Japanese working group on MGD proposed diagnostic criteria for obstructive MGD ( Table ). 4 , 20 , 21 According to these diagnostic criteria, obstructive MGD is considered present when ocular symptoms, anatomic abnormalities, and obstruction of meibomian glands are present. Table Diagnostic Criteria for Obstructive Meibomian Gland Dysfunction Proposed by the Japanese MGD Working Group Table Diagnostic Criteria for Obstructive Meibomian Gland Dysfunction Proposed by the Japanese MGD Working Group Prevalence The prevalence of MGD ranges from 3.6% to 68.0%. 22 – 28 The prevalence of MGD is higher in Asians (46.2%–68.0%) 24 – 28 than in Caucasians (3.6%–30.5%). 22 , 23 However, these studies used different diagnostic parameters, namely, telangiectasia and plugging, 22 – 27 gland dropout, 28 and meibum expressibility. 28 Therefore, the prevalence of MGD in these studies cannot be compared directly. Amano and Inoue 29 investigated the prevalence of MGD in Japanese patients using the same diagnostic criteria used in a previous population-based study conducted in Spain. 23 MGD was diagnosed when one or more of the following signs were present in at least one eye: viscous or waxy white secretion upon digital expression, presence of two or more lid margin telangiectases, and plugging of two or more gland orifices. The estimated prevalence of symptomatic and total (symptomatic + asymptomatic) MGD was 11.2% and 74.5%, respectively, in Japanese patients and 8.6% and 30.5%, respectively, in Spanish patients; this suggested that the prevalence of MGD is higher in Asians than in Caucasians. Using the diagnostic criteria proposed by the Japanese working group on MGD, Amano and Inoue 21 estimated the prevalence of MGD in the Japanese population. The study included 510 participants. The prevalence of symptomatic MGD and total (symptomatic + asymptomatic) MGD was 18.0% and 47.5%, respectively. The prevalence of total MGD increased significantly with increasing patient age ( P < 0.0001). Slit-lamp findings (lid margin abnormalities, shift of the mucocutaneous junction, telangiectasia, and plugging) were more frequent, the tear film breakup time was shorter, and the meiboscore was higher in the total MGD group than in participants without MGD. Therapy The management and treatment subcommittee of the International Workshop on MGD proposed a treatment algorithm in which treatment is added depending on the severity of MGD. 30 The sequence of treatment addition is eyelid hygiene, eyelid warming and massage, artificial lubricants, topical azithromycin, topical emollient lubricant, oral tetracycline derivatives, lubricant ointment, and anti-inflammatory therapy. Lid Hygiene and Warm Compression Eyelid warming and massage have been the basic treatments for MGD. Recently, a thermopulsation treatment system (Lipiflow, TearScience, Inc.) was introduced as an automated alternative for eyelid warming and massage. In three randomized clinical trials, 31 – 33 a single application of Lipiflow improved meibomian gland secretion, the tear breakup time, and ocular symptoms up to 1 or 3 months after treatment, and the results were better than or at least similar to those achieved with the daily application of conventional warm compression methods. In nonrandomized comparative studies 34 , 35 and noncomparative studies, 36 , 37 Lipiflow improved meibomian gland secretion, the tear breakup time, and ocular symptoms for 3 to 12 months. Yeo et al. 38 showed that the tear evaporation rate was significantly decreased from baseline up to 3 months after a single application of Lipiflow in patients with MGD. The decrease in the tear evaporation rate is larger after Lipiflow application than after twice-daily lid warming with a hot towel. These results suggest that Lipiflow is a useful treatment for MGD that does not depend on patient compliance. Kobayashi et al. 39 evaluated the effects of a newly developed eye-cleansing formulation for MGD. The product contains components that are anti-inflammatory and moisturizing and promote hair growth. In patients with MGD, significant improvements were observed in parameters such as subjective symptoms and meibum secretion. Kaido et al. 40 investigated the efficacy of eyelid margin cleansing with ofloxacin ointment in patients with obstructive MGD and found that slit-lamp parameters and fluorescein staining scores significantly decreased, while the tear breakup time significantly increased, after the treatment. In addition, the symptoms alleviated after treatment in most cases. These results suggested that cleansing with ofloxacin ointment is effective for patients with obstructive MGD. In another study, Arita et al. 41 evaluated the effect of commercially available eyelid warming devices on ocular temperatures, tear film function, and meibomian glands in normal subjects and patients with MGD. Two nonwet and three wet devices were compared. A single treatment session with each of the five warming devices used alone improved the ocular symptoms score, the tear breakup time, and ocular temperatures. In the repeated warming session, Azuki no Chikara, a nonwet warming device, induced a stable improvement in the tear breakup time and increased the conjunctival temperature. It also improved the meibum grade. These results suggest that repeated eyelid warming with a nonwet device improves tear film and meibomian gland function in patients with MGD. Lid hygiene and warm compression have been the treatments of choice for MGD. The devices and drugs newly developed in Japan may enhance the efficacy of lid hygiene and warm compression in patients with MGD. Intense Pulsed Light (IPL) Another new therapeutic modality is IPL therapy. IPL therapy has been an effective treatment for a range of dermatologic diseases, and it results in the alleviation of telangiectasia and facial erythema. 42 Therefore, IPL therapy has been evaluated as a treatment for MGD. Craig et al. 42 evaluated the effects of IPL therapy for MGD in a prospective, double-masked, placebo-controlled, paired-eye study and found that the lipid layer grade, tear breakup time, and symptom score improved from baseline up to day 45. Yin et al. 43 compared the results of IPL therapy and eyelid hygiene and found that IPL therapy and eyelid hygiene were equally effective in improving symptoms and meibomian gland function. Jiang et al. 44 evaluated the efficacy of IPL therapy in a prospective noncomparative study and found that IPL improved symptoms, the tear breakup time, and the meibomian gland secretion quality and expressibility. In two prospective, noncomparative studies, 45 , 46 serial IPL therapy sessions combined with meibomian gland expression improved symptoms and signs, including the meibomian gland secretion quality and expressibility. Proposed mechanisms by which IPL improves MGD signs and symptoms include heat transfer, thrombosis of the vasculature around the meibomian glands, and reduced inflammatory cytokines in tears. 42 , 47 However, the mechanism needs to be elucidated in future studies. Anti-Inflammatory Treatment Anti-inflammatory treatment is important for MGD. Zhang et al. 48 used 1% azithromycin eye drops for 4 weeks in 16 patients with MGD and examined changes in the expression of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva. The expression of proinflammatory mediators (interleukin [IL]-1β, IL-8, and matrix metalloproteinase 9) and transforming growth factor beta-1 (TGF-β1) was higher and lower, respectively, in patients with MGD than in healthy individuals. The expression of proinflammatory mediators decreased during treatment, although the levels returned to pretreatment values at 4 weeks after azithromycin withdrawal. Expression of TGF-β1 increased during treatment and remained at levels similar to those in healthy controls after drug withdrawal. These results suggest that the topical application of azithromycin is likely to reduce the inflammation in the eyelid and ocular surface of patients with MGD by changing the expression of pro- and anti-inflammatory mediators. Perry et al. 49 investigated the efficacy of topical cyclosporine A 0.05% (tCsA) for the treatment of MGD in a prospective study. Thirty-three patients with symptomatic MGD were randomized to receive either tCsA or placebo twice daily for 3 months. At the 3-month visit, several objective parameters, including the number of lid margin vascular injections, tarsal telangiectasis, and fluorescein staining scores, showed a significant improvement in the tCsA group, but not in the placebo group. The most significant finding was the greater decrease in the number of meibomian gland inclusions in the tCsA group than in the placebo group. These results suggest that topical CsA may be helpful in the treatment of MGD. Diquafosol Topical diquafosol solution has been used to treat dry eye because it increases fluid secretion from conjunctival epithelial cells and mucin secretion from conjunctival goblet cells via the P2Y 2 receptor. 50 Because P2Y 2 receptor expression is observed in sebaceous cells and ductal cells in the meibomian gland, 51 , 52 diquafosol is expected to have some effects on meibomian glands. Arita et al. 53 used 3% diquafosol ophthalmic solution in patients with obstructive MGD for more than 4 months. Ocular symptoms, lid margin abnormalities, the superficial punctate keratopathy score, and the meibum grade were decreased, while the tear breakup time, tear film meniscus area, and meibomian gland area were increased. These results suggest that topical diquafosol therapy is effective for patients with obstructive MGD. In addition, Amano and Inoue 54 administered topical 3% diquafosol ophthalmic solution for 3 months in patients with MGD. The number of telangiectases and plugged gland orifices significantly decreased after 1 month of treatment, while the meibum score and meiboscore significantly decreased at 3 months. The increase in the tear LLT at 20 minutes after diquafosol administration became statistically significant at 3 months. Altogether, diquafosol ophthalmic solution has the potential to improve signs and symptoms in patients with MGD. As described in Amano and Inoue's article, 54 a recent study by Kam et al. 55 reported that UTP, a P2Y 2 receptor agonist, had no effect on immortalized human meibomian gland epithelial cells. In contrast, Wen et al. found that P2Y 2 receptor agonists enhance lipid production in primary cultured rabbit meibocytes (Wen Q, et al. IOVS 2002;43:ARVO E-Abstract 3146). UTP easily degrades in aqueous solutions, which necessitates its use immediately after dissolution in water. 56 , 57 In contrast, diquafosol is stable when dissolved in water. 56 , 57 Because Kam et al. 55 did not mention whether UTP solutions were immediately used, it is not known for certain whether their results are applicable to the actions of diquafosol on meibomian gland acinar cells. Either way, our results suggest that topical diquafosol is beneficial to meibomian glands. Vitamin D3 Another promising drug for MGD is vitamin D3. Because hyperkeratinization is a major cause of obstructive MGD, maxacalcitol (a noncalcemic analogue of the active form of vitamin D3), which is effective for psoriasis and ichthyosis, is expected to be effective in patients with MGD. 58 Arita et al. 58 applied maxacalcitol ointment to the lid margins of patients with obstructive MGD for 2 months and observed a significant improvement in clinical parameters (scores for plugging of meibomian gland orifices and lid margin vascularity, the tear breakup time, the meibum grade, and the meibomian gland area). An analogue of vitamin D3 was found to improve the condition of patients with obstructive MGD. Association of MGD With Other Diseases and Conditions A few recent studies from Japan have described the association of MGD with other diseases or conditions. Arita et al. 59 examined tear film and meibomian gland parameters in patients with or without MGD and aqueous-deficient dry eye. Interestingly, meibomian gland losses had a positive correlation with tear secretion values only in patients with MGD. Therefore, the authors thought that the loss of meibomian glands is compensated for by an increase in tear secretion. As the authors discussed in the article, however, the mechanisms for this compensation need to be clarified in future studies. Matsumoto et al. 60 examined changes in the ocular surface and meibomian glands of 10 patients receiving an anticancer drug combination of tegafur, gimeracil, and oteracil potassium (S-1; Tahiho Pharmaceutical, Tokyo, Japan). Occluded orifices of meibomian glands and marked loss of meibomian glands on meibography were observed. In vivo confocal microscopy showed glandular atrophy and periglandular inflammation. The tegafur concentration in tears was high during the period of drug intake. These results suggest that S-1 damages the meibomian glands, with the most likely mechanism being the toxicity of the drug in tears. Ban et al. 61 examined the lipid layer of the tear film in patients with chronic graft versus host disease (GVHD) after hematopoietic stem cell transplantation (HST) using tear film lipid layer interferometry (DR-1; Kowa, Tokyo, Japan). The DR-1 score for severity was higher in patients with dry eye and GVHD after HST than in patients without dry eye. Moreover, the DR-1 score for severity was positively correlated with the dry eye severity. These results suggest that MGD is one of the mechanisms for dry eye due to GVHD. Future Directions To enable all patients with MGD to receive appropriate treatment, standardization of the diagnosis and treatment is necessary. To standardize the diagnosis of MGD, specific diagnostic criteria with cutoff values for each parameter are necessary. With the application of emerging novel technologies, new useful tools for MGD have been developed, such as noncontact meibography, in vivo confocal microscopy, and LipiView. Although these diagnostic devices are useful for visualizing subclinical changes related to MGD, they are expensive and not available in all clinics. Parameters that can be measured with devices available in most clinics should be used. Considering these requirements, the Japanese working group for MGD proposed a novel list of diagnostic criteria for obstructive MGD ( Table ). The validity of these new diagnostic criteria should be evaluated in future studies. The International Workshop on MGD proposed a treatment algorithm in which treatment is added depending on the severity of MGD. The sequence of treatment addition is eyelid hygiene, eyelid warming and massage, artificial lubricants, topical azithromycin, topical emollient lubricant, oral tetracycline derivatives, lubricant ointment, and anti-inflammatory therapy. However, the efficacy of this treatment algorithm is yet to be evaluated. In addition to these treatments, new therapeutic modalities such as LipiView and IPL have emerged. However, more clinical evidence is necessary for these new therapies to become a standard in the treatment of MGD. Acknowledgments Funding of the publication fee and administration was provided by the Dry Eye Society, Tokyo, Japan. The Dry Eye Society had no role in the contents or writing of the manuscript. Disclosure: S. Amano , Alcon (R), AMO (R), Otsuka (R), Pfizer (R), Santen (F, R), Senju (R) References 1. Korb DR, Henriquez AS. Meibomian gland dysfunction and contact lens intolerance. J Am Optom Assoc . 1980; 51: 243–251. 2. Nelson JD, Shimazaki J, Benitez-del-Castillo JM, et al. The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee. Invest Ophthalmol Vis Sci . 2011; 52: 1930–1937. 3. Li S, Zhou J, Bu J, et al. Ectodysplasin A protein promotes corneal epithelial cell proliferation. 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Do cyclosporine A, an IL-1 receptor antagonist, uridine triphosphate, rebamipide, and/or bimatoprost regulate human meibomian gland epithelial cells? Invest Ophthalmol Vis Sci . 2016; 57: 4287–4294. 56. Nichols KK, Yerxa B, Kellerman DJ. Diquafosol tetrasodium: a novel dry eye therapy. Expert Opin Investig Drugs . 2004; 13: 47–54. 57. Yerxa BR, Sabater JR, Davis CW, et al. Pharmacology of INS37217 [P(1)-(uridine 5′)-P(4)- (2′-deoxycytidine 5′)tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis. J Pharmacol Exp Ther . 2002; 302: 871–880. 58. Arita R, Kawashima M, Ito M, Tsubota K. Clinical safety and efficacy of vitamin D3 analog ointment for treatment of obstructive meibomian gland dysfunction. BMC Ophthalmol . 2017; 17: 84. 59. Arita R, Morishige N, Koh S, et al. Increased tear fluid production as a compensatory response to meibomian gland loss: a multicenter cross-sectional study. Ophthalmology . 2015; 122: 925–933. 60. Matsumoto Y, Dogru M, Sato EA, et al. S-1 induces meibomian gland dysfunction. Ophthalmology . 2010; 117: 1275. 61. Ban Y, Ogawa Y, Goto E, et al. Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease. Eye (Lond) . 2009; 23: 202–208. Figure The eyelids of mice fed a normal diet ( A , B ) and a special diet with limited lipid content (the HR-AD diet) ( C , D , E ) for 11 weeks, from 5 to 16 weeks of age. Rounding ( C ), plugging and telangiectasia ( D , arrowheads ), and toothpaste-like meibum ( E , arrowheads ) can be seen. This figure was extracted from Miyake H, Oda T, Katsuta O, Seno M, Nakamura M. Meibomian gland dysfunction model in hairless mice fed a special diet with limited lipid content. Invest Ophthalmol Vis Sci . 2016;57:3268–3275, with permission from the Association for Research in Vision and Ophthalmology. Figure The eyelids of mice fed a normal diet ( A , B ) and a special diet with limited lipid content (the HR-AD diet) ( C , D , E ) for 11 weeks, from 5 to 16 weeks of age. Rounding ( C ), plugging and telangiectasia ( D , arrowheads ), and toothpaste-like meibum ( E , arrowheads ) can be seen. This figure was extracted from Miyake H, Oda T, Katsuta O, Seno M, Nakamura M. Meibomian gland dysfunction model in hairless mice fed a special diet with limited lipid content. Invest Ophthalmol Vis Sci . 2016;57:3268–3275, with permission from the Association for Research in Vision and Ophthalmology. Table Diagnostic Criteria for Obstructive Meibomian Gland Dysfunction Proposed by the Japanese MGD Working Group Table Diagnostic Criteria for Obstructive Meibomian Gland Dysfunction Proposed by the Japanese MGD Working Group
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SAE MOBILUS Development of a Fuel Injected Two-Stroke Gasoline Engine Technical Paper 880170 ISSN: 0148-7191 , e-ISSN: 2688-3627 DOI: https://doi.org/10.4271/880170 Published February 01, 1988 by SAE International View list of content related to the publisher(s) in United States Sector: Automotive Content related to Automotive Event: SAE International Congress and Exposition Technical Paper presented at SAE International Congress and Exposition Language: English Abstract AVL's development of a semi-direct injected two-stroke engine employed a carburetted 250cc production motorcycle engine as a baseline. Special emphasis vas placed on the investigation of fuel jet and scavenge flow interactions. To evaluate the scavenge flow pattern, a steady flow test procedure was developed and applied. The results of scavenging system optimization were confirmed by subsequent engine tests which showed significant gains in power output. Completion of the first phase of the research program resulted in the development of a semi-direct injection system using currently available automotive low pressure manifold injection system components. Compared to the original carburetted engine, significant improvanents were demonstrated, including a 30% reduction of fuel consumption, a reduction of up to 60% in hydrocarbon emissions and up to 70% in carbon monoxide emission, averaged over the engine's speed and load range. Engine BMEP and power characteristics were maintained and improved. In addition, the critical idle operating conditions were improved significantly by stabilizing the combustion whith minimized cyclic variations. The results of thermodynamic cycle analyses, based both on engine test measurements and on calculations, are presented. Finally, the paper compares the semi-direct and direct injection systems and presents an outlook based on some of the results of the current phase of AVL's low emission two-stroke engine research program. Authors Diethard Plohberger Works by Diethard Plohberger - AVL—List GmbH. Graz. Austria Content by authors affiliated with AVL—List GmbH. Graz. Austria Leo A. Mikulic Works by Leo A. Mikulic - AVL—List GmbH. Graz. Austria Content by authors affiliated with AVL—List GmbH. Graz. Austria Klaus Landfahrer Works by Klaus Landfahrer - AVL—List GmbH. Graz. Austria Content by authors affiliated with AVL—List GmbH. Graz. Austria Topic Carbon monoxide Content related to Carbon monoxide Hydrocarbons Content related to Hydrocarbons Fuel consumption Content related to Fuel consumption Two stroke engines Content related to Two stroke engines Combustion and combustion processes Content related to Combustion and combustion processes Plohberger, D., Mikulic, L., and Landfahrer, K., "Development of a Fuel Injected Two-Stroke Gasoline Engine," SAE Technical Paper 880170, 1988, https://doi.org/10.4271/880170 . Also In SAE Transactions Journal of Engines Number: V97-6 ; Published: 1989-09-01 References Oschatz, W. “Kraftstoffaufbereitung durch die Einspritzdüse” Deutsche Kraftfahrtforschung, Heft 57 VDI Verlag Berlin 1941 Friedel. “Gemischbildung und Düsenentwicklung am Ein-spritz-Zündermotor; II. Bericht, Die Wirkung von Luftströmen auf Kraftstoffstrahlen” Deutsche Luftfahrtforschung, Untersuchungen und Mitteilungen Nr. 6936 Dresden 1944 Rothrock, A. M. Spencer R. C. “Effect of Moderate Air flow on Fuel Sprays after Injection Cut Off” Report National Committee for Aeronautics No. 483 1933 Bianchi, L. “Bombenversuche über Gemischbildung und Verbrennung bei Benzineinspritzung” Deutsche Kraftfahrtforschung, Zwischenbericht Nr. 94 1941 Kühl, H. “Grundlagen der Gemischregelung beim Einspritz-Ottomotor mit Durchspülung” Deutsche Luftfahrtforschung, Forschungsbericht Nr. 1546 1942 Augustin, U. “Die Einspritzung von Leichtkraftstoffen in Flugmotoren” ATZ 47 1944 3/4 30 Brook, K. Nicolls “Some Aspects of Petrol-Injections” Equipment Developments 1947/48 Campbell, J. F. “Fuel Injection as Applied to Aircraft Engines” SAE Journal 36 1935 77 Dollinger “Untersuchungen an einem Zweitaktmotor mit Kraftstoffeinspritzung” Deutsche Kraftfahrtforschung, Zwischenbericht Nr. 9 Schmidt, U. Froede W. “Zweitaktmotoren mit Benzineinspritzung” Deutsche Kraftfahrtforschung, Zwischenbericht Nr. 68 1938 Morghen, K. “Die Energieumsetzung im Zweitakt-Otto-motor mit Umkehrspülung bei Benzineinspritzung” Deutsche Luftfahrtforschung, Forschungsbericht Nr. 1688 1942 Morghen, K. “Die Energieumsetzung im Zweitakt-Otto-motor bei Benzineinspritzung” ZWB Forschungsbericht Nr. 1740 1942 Froede, W. “Sonderfragen der Benzineinspritzung” Deutsche Kraftfahrtforschung, Zwischenbericht Nr. 363 1940 Scherenberg, H. “Rückblick über 25 Jahre Benzin-Einspritzung in Deutschland” MTZ 16 9 September 1955 Voit, W. Stoll, H. “Benzineinspritzung am Fahrzeug-Ottomotor” MEZ 13 9 September 1952 Froede, W. “Benzineinspritzung für kleine Zylinder von Ottomotoren” MIZ 57 8 August 1955 “Zweitakteinspritzung bei Gutbrod und Goliath” MTZ 13 10 Oktober 1952 Groth, K. “Das Betriebsverhalten des schnellaufenden Zwei taktottonetors mit Einspritzung und seine Ent-wicklungsmöglichkeiten” Deutsche Kraftfahrtforschung und Straβenverkehrstechnik 1959 Kuentscher, V. “Ladungsschichtung und Hagerkonzept-Verbrennung ira Zweitakt-Ottomotor mit elektronisch gesteuerter Druckstoβeinspritzung” Wissenschaftliche Beiträge der IH Zwickau 10 1984 Nuti, R. “Direct Fuel Injection: An Opportunity for Two-Stroke SI Engines in Road Vehicle use” SAE Paper 860170 1986 Vieilledent, E. “Low Pressure Fuel Injection System for Two-Stroke Engines” SAE Paper 780767 1987 Douglas, R. Blair, G.P. “Fuel Injection of a Two-Stroke Cycle Spark Ignition Engine” SAE Paper 820952 1982 Grasas-Alsina, C. et al. “Low Pressure discontinous Gasoline Injection in Two-Stroke Engines” SAE Paper 860168 1986 Bizjan, F. Pavletic, R. “The Nozzle Location and the Shape of Its Surroundings in the Cylinder of Small Two-Stroke Engine'” SAE Paper 860169 1986 List, H. Niedermayer, E. “Versuche an der Zweitakt-dieselmaschine” Forschung auf den Gebiete des In-genieurwesens Band 8 Berlin 1937 Niedermayer, E. “Zusammenhänge zwischen Ladungswechsel und Leistung beim Zweitaktmotor” MIZ 1941 Niedermayer, E. “Untersuchung des Spülvorganges an Zweitaktdieselraaschinen” Forschung auf dem Gebiete des Ingenieurwesens (VDI) 1936 Hold, P. “Untersuchungen von Spülsystemen an der zündenden Zweitaktmaschine” MIZ 1940 Blair, G.P. Kenny, R.G. “Further Developments in Scavenging Analysis for Two-Cycle Engines” SAE Paper 800038 1980 Nuti, H. Martorano, L. “Short-Circuit Ratio Evaluation in the Scavenging of Two-Stroke SI Engines” SAE Paper 850177 1985 Endres, W. Danner, M. “Spülluft, Verbrennungsgase und Mischzone im Zylinder des Zweitaktmotors” MTZ 1959 Ohigashi, S. “Spüulvorgang bei Zweitaktmotoren mit um-kehrspülung” HTZ 1959 Sanborn, D.S. Blair, G.P. et al. “Experimental Assessment of Scavenging Efficiency of Two-Stroke Cycle Engines” SAE Paper 800975 1980 Sanborn, D.S. Roeder, W.M. “Single Cycle Simulation Simplifies Scavenging Study” SAE Paper 850175 1985 Sweeney, Kenny Swann, Blair “Single Cycle Gas Testing Method for Two-Stroke Engine Scavenging” SAE Paper 850178 1985 Jante, A. “Scavenging and Other Problems of Two-Stroke Cycle Spark-Ignition Engines” SAE Paper 680468 1968 Blair, G.P. “Studying Scavenge Flow in a Two-stroke Cycle Engine” SAE Paper 750752 1975 Jaros, K. “Eine neue Methode zur Bemessung und Bewertung der Spülvorgänge bei Zweitaktmotoren” Kraftfahrzeugtechnik Heft 6 Berlin 1986 Blair, G.P. Ashe M.C. “The Unsteady Gas Exchange Characteristics of a Two-Cycle Engine” SAE-Paper 760644 1976 Munoz, H. et al. “Two-Stroke Engines-Models for Charge Renovation” SAE-Paper 850084 1985 Becker, K. et al. “Umweltproblere bei motorisierten Zweirädem” Kontakt und Studium Band 119 Expert Verlag BRD 1984 Product Code Document Title File Type Download 880170 Development of a Fuel Injected Two-Stroke Gasoline Engine Download File Type Download Citation File Format: .xlsx .csv Text Number of Results: Selected 25 50 100 All(upto 1000) Select Fields to Export Item Number Content Type Title Author(s) Affiliation(s) Publisher Publish Date Abstract/scope Citation DOI Submit
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Congresswoman Calls for Examination of Military Pretrial Confinement — ProPublica The Army also said its pretrial confinement rules are “currently under revision” in a statement to Military Times, which is partnering with ProPublica and The Texas Tribune to report on military justice. Rep. Veronica Escobar, D-Texas, has called for hearings over the military’s pretrial confinement system. Credit: Jason Garza for The Texas Tribune Military Congresswoman Calls for Examination of Military Pretrial Confinement The Army also said its pretrial confinement rules are “currently under revision” in a statement to Military Times, which is partnering with ProPublica and The Texas Tribune to report on military justice. A Texas representative whose district includes one of the nation’s largest Army posts is calling for hearings to examine the military’s pretrial confinement system, which gives commanders the discretion to detain service members facing criminal charges ahead of trial. “Pretrial confinement had not been on my radar, so it was really eye-opening,” Escobar said of the investigation, which highlighted the case of Christian Alvarado, a private first class who avoided detention for months despite facing sexual assault accusations from multiple women. Alvarado, who has since been convicted of sexually assaulting two of those women, was a soldier at Fort Bliss. Escobar’s district includes the post. Escobar, who is vice chair of theHouse Subcommittee on Military Personnel, said that during the congressional hearings she would like to explore ways to ensure all cases across the military are held to the same standard. She also said she reached out to the new commanding general of Fort Bliss to ask more about Alvarado’s case. Fort Bliss officials have declined to discuss with the news organizations why Alvarado was not initially put in pretrial confinement, saying they would not comment on internal deliberations. The congresswoman has discussed the issue withRep. Jackie Speier, D-Calif., who chairs the subcommittee. Speier shares Escobar’s concerns and believes pretrial confinement should be “part of the broader work of military justice reform,” her office said. A staffer in Speier’s office said the chair looks forward to learning more from military officials about pretrial confinement at a planned subcommitteehearing on Wednesdaythat will focus on the implementation of military justice reforms. Army spokesperson Matt Leonard told Military Times that the rules governing pretrial confinement are “currently under revision.” He declined to provide details, referring questions to the Department of Defense. A DOD spokesperson said the military doesn’t have any “updates to announce at this time.” News of the proposed revisions comes after publication of the ProPublica-Tribune investigation and ofan article by Military Times that detailed another casein which a soldier was not placed in pretrial confinement despite multiple domestic violence allegations. The news organizations are partnering to cover aspects of the military justice system. Under the current rules that are outlined in the Manual for Courts-Martial, commanders must determine if there’s good reason to believe a service member committed a crime and weigh whether the person is likely to flee before trial or engage in serious criminal misconduct. They must also first consider if less stringent restrictions are enough to keep service members out of trouble. Unlike in the civilian justice system, there is no bail in the military. Rachel E. VanLandingham, a former Air Force judge advocate, said commanders should not control pretrial confinement because they are not trained as military attorneys. Commanders can override the advice of legal advisers in many situations. “Because these commanders are F-16 pilots, these commanders are infantry officers, this is not their full-time job,” said VanLandingham, now a professor at Southwestern Law School in Los Angeles. Congress last year overhauled much of the military justice system, stripping commanders of the power to decide whether or not to prosecute some felony-level crimes, including sexual assault. Amid pushback from military leaders, lawmakers allowed commanders to retain numerous powers, including the ability to place a service member in pretrial confinement. Escobar had hoped to see broader reforms that would have removed commanders’ prosecutorial authority over all serious crimes, including robbery, assault and distribution of controlled substances. She said that taking away commanders’ control of pretrial confinement is “a possibility we absolutely should consider.” Despite facing sexual assault accusations from three women in 2020, Alvarado was not placed in pretrial confinement, according to the news organizations’ investigation. While being interviewed by an Army investigator about the first two allegations, Alvarado admitted that he continued to have sex with one of the women after she passed out. A month later, he sexually assaulted a third woman, which he admitted in text messages to the woman. But Alvarado’s commanders did not place him in pretrial confinement until more women accused him of assault. A military judge later found him guilty of sexually assaulting two women and strangling one of those two women. He was sentenced to 18 years in a military prison and a dishonorable discharge. Alvarado’s case is currently under appeal. His appeals attorneys did not respond to a request for comment. “That was shocking to me,” Escobar said. “When you have clear evidence of someone who is a repeat offender, that in and of itself, to me, merits pretrial confinement, and one of the things I do want to know about is why didn’t it happen?”
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B831 Standard Test Method for Shear Testing of Thin Aluminum Alloy Products Significance and Use 5.1 The intent of this test method is to provide a means of measuring the ultimate shear strength of thin aluminum alloy wrought and cast products. It is recognized that the loading conditions developed by this test method, and by mos Standard Active ASTM B831-22 Standard Test Method for Shear Testing of Thin Aluminum Alloy Products ASTM|B0831-22|en-US Standard Test Method for Shear Testing of Thin Aluminum Alloy Products Standard B831 Standard Test Method for Shear Testing of Thin Aluminum Alloy Products> new BOS Vol. 02.02 Committee B07 $ 57.00 In stock Significance and Use 5.1The intent of this test method is to provide a means of measuring the ultimate shear strength of thin aluminum alloy wrought and cast products. It is recognized that the loading conditions developed by this test method, and by most others, are not ideal in that they do not strictly satisfy the definitions of pure shear. However, rarely do pure shear conditions exist in structures. Note 1: Results from this test method are not interchangeable with results from Test Methods B565 and B769 . Shear strengths obtained by this test method have been shown to differ from values determined with other methods. 3 Scope 1.1This test method covers single shear testing of thin wrought and cast aluminum alloy products to determine shear ultimate strengths. It is intended for products that are too thin to be tested according to Test Method B769. 1.2The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard. 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. 1.4 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee. Price : $57.00 B. Fees: 8. Verification.ASTM has the right to verify compliance with this Agreement, at its expense, and at any time during the course of normal business hours. 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Dryopteris pentheri (Krasser) C.Chr. wfo-0001111582 Dryopteris pentheri (Krasser) C.Chr. Index Filic. 284. 1905 This name is reported byDryopteridaceaeas an accepted name in the genusDryopteris(familyDryopteridaceae).The record derives from Tropicoswhich reports it as an accepted name (record26605654) Dryopteris pentheri (Krasser) C.Chr. Index Filic. 284. 1905 Description Synonyms Bibliography Cite taxon page as 'WFO (2023): Dryopteris pentheri (Krasser) C.Chr. Published on the Internet;http://www.worldfloraonline.org/taxon/wfo-0001111582. Accessed on: 21 Jun 2023' Diagnostic Description Dryopteris pentheri is distinguished from the similar D. inaequalis and D. lewalleana, by the cylindrical glands and 2-celled hairs occurring on the frond axes and veins. The glands, stomata and spores are also larger than those of both D. inaequalis and D. lewalleana, this as a result of it being a tetraploid rather than a diploid (as the other two species). Dryopteris pentheri also occupies exposed habitats more frequently than D. inaequalis and D. lewalleana. Provided by: [B]. e-Flora of South Africa Source: [ 5 ]. Morphology Terrestrial or epilithic. Rhizome prostrate. Fronds erect to arching, 2- or 3-pinnate, conspicuously basiscopically developed, lamina ovate to ovate-triangular, up to 780 mm long, glabrous or with few hairs along costules adaxially, abaxial surface with sparse unicellular glands, 2-celled hairs and scales mostly along costules and veins; pinnules lanceolate to oblong-acuminate. Sporangia in circular sori with reniform indusium. Provided by: [B]. e-Flora of South Africa Source: [ 3 ]. Plants terrestrial or epilithic. Rhizome decumbent, sparsely branched, to 300 mm long, to 20 mm in diameter, set with roots, closely spaced stipe bases, and scales, scales chartaceous, stramineous to ferrugineous, adnate, linear, oblong or narrowly ovate, base truncate, margins irregularly set with long, twisted, pluricellular filiform outgrowths, apex filiform, twisted, to 37 mm long, to 6 mm wide. Fronds caespitose, erect to arching, to 1.8 mm long; stipe firm, proximally castaneous, brown to stramineous higher up, proximally adaxially flattened, shallowly sulcate higher up, to 485 mm long, to 10 mm in diameter, proximally densely scaled, scales higher up fugaceous, chartaceous, stramineous to ferrugineous, larger adnate, smaller sessile or short-stalked, narrowly lanceolate to filiform, cordate to cuneate, margins irregularly set with long, twisted, pluricellular filiform outgrowths and often also with scattered glands, apex filiform, to 40 mm long, to 7 mm wide; lamina anadromous, catadromous towards the apex, herbaceous to firmly herbaceous, ovate to ovate-triangular, 2- or 3-pinnate, to 780 mm long, with up to 16 petiolated pinna pairs; rachis stramineous, adaxially shallowly sulcate, becoming narrowly winged towards the apex, initially moderately scaled, scales fugaceous, adnate or short-stalked, narrowly lanceolate to linear, cuneate, margins irregularly set with long, filiform outgrowths, often also with scattered glands, apex filiform, twisted, to 7 mm long, to 2 mm wide; pinnae petiolate, petiole to 18 mm (rarely to 38 mm) long, basal pinna pair inequilaterally ovate to narrowly ovate, narrowly lanceolate to oblong-acuminate towards the lamina apex, to 2-pinnate, basal pair the longest, usually basiscopically developed, to 315 mm long, to 185 mm wide, opposite to alternate, basally widely spaced, often somewhat imbricate higher up, with up to 9 petiolated pinnule pairs; pinna-rachis adaxially shallowly sulcate, sulcus confluent with that of the rachis, pronounced abaxially, narrowly winged distally, abaxially moderately to sparsely set with scales and hairs, scales and hairs chartaceous to membranous, stramineous to ferrugineous, adnate or short-stalked, narrowly to broadly cuneate, margins irregularly set with long pluricellular, filiform outgrowths, apex filiform, twisted, to 5 mm long, to 1.6 mm wide, hairs are of three types: 1) unicellular oblong glands, 2) bicellular hairs with straight or oblique transverse walls, and, 3) pluricellular simple or branched, usually isocytic hairs; pinnules petiolate, petiole to 3 mm long, equilaterally to inequilaterally lanceolate to oblong-acuminate, basiscopically decurrent, 1-pinnate to lobed, acroscopic pinnule on the basal pinnae to 90 mm long, to 35 mm wide, basiscopic pinnule on the basal pinnae to 112 mm long, to 42 mm wide, widely spaced or imbricate; costa adaxially shallowly sulcate, pronounced abaxially, narrowly winged, wing continuous with that of the pinna-rachis, variously set with scales, isocytic and 2-celled hairs; segments widely spaced to imbricate, ovate to oblong-obtuse, basiscopically decurrent, to 22 mm long, to 9 mm wide, lobed, lobes serrate, adaxially glabrous or with a few pluricellular usually isocytic hairs along the costule, abaxially sparsely set with unicellular oblong glands (60-)137(-260) µm long, 2-celled hairs, and isocytic and/or moniliform hairs, those near the segment base often with a glandular cell near the base, and filiform scales, scales short-stalked, stalk often with one or more glandular cells, hairs and scales usually occur along the costule and veins. Venation anadromous, becoming catadromous towards the lamina and pinna apex, pinnately branched in the segments, vein branches pinnately branched, forked or simple near the apex, evident, ending in the teeth near the margin, endings slightly enlarged and often conspicuous adaxially. Stomata of the anomocytic and polocytic types, (34-)53(-72) µm long. Sori circular, medial on the predominantly anadromous vein branches, discrete, to 1.8 mm in diameter at maturity, mainly uniseriate; sporangium stalk simple, or with one or more glandular cells, but usually with a long uniseriate hair, capsule with (11-)13(-20) indurated annulus cells, epistomium (3-)6(-8)-celled, hypostomium (3-)6(-8)-celled. Indusium firmly herbaceous, persistent, pale brown, reniform, entire or repand, to 1.8 mm in diameter. Spores ellipsoidal, monolete, perispore folded into tubercules or reticulate ridges, finely rugose to ruminate, (38-)45.08(-60) x (27-)31.32(-40) µm. Provided by: [B]. e-Flora of South Africa Source: [ 4 ]. Plants terrestrial or epilithic. Rhizome short-decumbent, sparsely and irregularly branched, to 20 mm in diameter, set with roots, closely spaced stipe bases and scales, the scales stramineous to ferrugineous, chartaceous, broadly attached, linear, oblong or narrowly ovate, to 37 x 6 mm, truncate, the margins irregularly set with long, twisted, pluricellular filiform outgrowths, the scale apex filiform, twisted. Fronds cµspitose, erect to arching, to 1.8 m long; stipes proximally castaneous, brown to stramineous higher up, proximally adaxially flattened, shallowly sulcate higher up, to 485 mm long, to 10 mm in diameter, proximally densely scaled, the scales higher up fugaceous, stramineous to ferrugineous, chartaceous, the larger scales to 40 x 7 mm, broadly attached, the smaller scales sessile or short-stalked, narrowly lanceolate to filiform, cordate to cuneate, the margins irregularly set with long, twisted, pluricellular filiform outgrowths and often also with scattered glands, the scale apex filiform; laminµ anadromous, catadromous towards the apex, herbaceous to firmly herbaceous, 2-pinnate to 3-pinnate, ovate to ovate-triangular, to 780 mm long, to 460 mm wide, with up to 16 petiolated pinna pairs; rachises stramineous, adaxially shallowly sulcate, becoming narrowly winged towards the apex, initially moderately scaled, the scales fugaceous, broadly attached or short-stalked, narrowly lanceolate to linear, to 7 x 2 mm, cuneate, the margins irregularly set with long, filiform outgrowths, often also with scattered glands, the scale apex filiform, twisted; pinnµ petiolate, the petiole to 18 mm (rarely to 38 mm) long, the basal pinna pair inµquilaterally ovate to narrowly ovate, narrowly lanceolate to oblong- acuminate towards the lamina apex, to 315 mm long, to 185 mm wide, to 2-pinnate, the basal pair the longest, mostly basiscopically developed, subopposite to alternate, basally widely spaced, often somewhat imbricate higher up, with up to 9 petiolated pinnule pairs; pinna-rachises adaxially shallowly sulcate, the sulcus confluent with that of the rachis, pronounced abaxially, narrowly winged distally, abaxially moderately to sparsely set with scales and hairs, the scales and hairs stramineous to ferrugineous, chartaceous to membranous, broadly attached or short-stalked, to 5 x 1.6 mm, narrowly to broadly cuneate, the margins irregularly set with long pluricellular, filiform outgrowths, the scale apex filiform, twisted, the hairs are of three types, 1) unicellular cylindrical glands, 2) bicellular hairs with straight or oblique transverse walls, and 3) pluricellular simple or branched, mostly isocytic hairs often bearing a single gland near the base; pinnules petiolate, the petiole to 3 mm long, the pinnules symmetric to inµquilaterally lanceolate to oblong-acuminate, basiscopically decurrent, 1-pinnate to lobed, the acroscopic pinnule on the basal pinnµ to 90 mm long, to 35 mm wide, basiscopic pinnule on the basal pinnµ to 112 mm long, to 42 mm wide, widely spaced or imbricate; costµ adaxially shallowly sulcate, pronounced abaxially, narrowly winged, the wing continuous with that of the pinna-rachis, variously set with scales, isocytic hairs and 2-celled hairs; segments widely spaced to imbricate, ovate to oblong- obtuse, to 22 mm long, to 9 mm wide, basiscopically decurrent, lobed; lobes serrate, adaxially glabrous, with oblong glands along and between the veins, or with a few pluricellular mostly isocytic hairs along the costules, abaxially sparsely set with cylindrical glands (60-)137(-260) µm long, 2-celled hairs, and isocytic and/or moniliform hairs, those near the segment base often with a gland near the base, and filiform scales, the scales short-stalked, the stalk often with one or more glandular cells, hairs and scales mostly occurring along the costules and veins. Venation anadromous, becoming catadromous towards the lamina and pinna apex, pinnately branched in the segments, the vein branches pinnately branched, forked or simple near the apex, evident, ending in the teeth near the margin, the endings slightly enlarged and often conspicuous adaxially. Stomata of the anomo- and polocytic types, guard cells (34-)53(-72) µm long. Sori circular, to 1.8 mm in diameter at maturity, medial on the predominantly anadromous vein branches, discrete, essentially uniseriate in the segments; sporangia stalk simple, or with one or more glandular cells, but mostly with a long multicellular, uniseriate hair, the capsule with (11-)13(-20) indurated annulus cells, epistomium (3-)6(-8)-celled, hypostomium (3-)6(-8)-celled. Indusia persistent, pale brown, firmly herbaceous, reniform, to 1.8 mm in diameter, the margins entire, repand, or erose, (rarely glandular along margin), often strongly revolute. Spores ellipsoidal, monolete, perispore folded into tubercules or reticulate ridges, finely rugose to ruminate, (38-)45(-60) x (27-)31(-40) µm. Provided by: [B]. e-Flora of South Africa Source: [ 5 ]. Rhizomatous perennial. Fronds erect to arching, to 1.8 m long, stipe proximally densely scaled, lamina ovate to ovate-triangular, 2- or 3-pinnate, with up to 16 petiolated pinna pairs, basal pinna pair ovate to narrowly ovate, generally not reduced, segments herbaceous, ovate to oblong-obtuse, lobed, glabrous above, or glandular along and between veins, or with a few hairs along costule, below sparsely glandular with 2-celled and multicellular hairs. Sori to 1.8 mm diam.; indusium entire, repand, or erose. Provided by: [B]. e-Flora of South Africa Source: [ 6 ]. Ecology Terrestrial margin of forest; 6, 000 to 10, 000 ft. alt. Provided by: [C]. Plants Of the World Online Portal - FWTA Source: [ 1 ]. Habitat Mesic Grassland. Moist rocky areas, streambanks, forests and forest margins. Provided by: [B]. e-Flora of South Africa Source: [ 3 ]. Terrestrial, in light shade along forest margins, in scrub and at boulder bases in open grassveld. Not edaphically bound. Provided by: [B]. e-Flora of South Africa Source: [ 4 ]. The species occurs from near sea-level in the southern Cape to 2425 m in Lesotho. Although predominantly confined to moist forests, at higher elevations it occurs in open habitats. In these habitats, however, plants are mostly confined to boulder bases and rock crevices on ridges and along mountain streams. Dryopteris pentheri also inhabits disturbed sites, such as road cuts and old pine plantations. Provided by: [B]. e-Flora of South Africa Source: [ 5 ]. Mostly in deeply shaded forests and forest margins, 100-250 m. Provided by: [B]. e-Flora of South Africa Source: [ 6 ]. Distribution The species is widespread in sub-Saharan Africa. Provided by: [B]. e-Flora of South Africa Source: [ 4 ]. Dryopteris pentheri is widespread in the eastern and western mountainous regions of sub-Saharan Africa, occurring in Bioko, Burundi, Cameroon, the Democratic Republic of the Congo, Ethiopia, Guinea, Guinea-Bissau, Kenya, Lesotho, Liberia, Madagascar, Malawi, Mozambique, Nigeria, Reunion, Rwanda, São Tomé, Sierra Leone, South Africa, Sudan, Swaziland, Tanzania, Uganda, Zambia and Zimbabwe. Provided by: [B]. e-Flora of South Africa Source: [ 5 ]. Cape Peninsula to Tsitsikamma and E and W Africa and Madagascar. Provided by: [B]. e-Flora of South Africa Source: [ 6 ]. Synonyms Nephrodium pentheri Krasser Provided by: [D].Polypodiaceae Bibliography 1Aspidiaceae, A. H. G. Alston. Flora of West Tropical Africa. Ferns and Fern-Allies Supplement. 1959 2Ind. Fil. 284 (1905). 3Klopper, RR. 2017. Pteridophyta. In: E Retief & NL Meyer (eds), Plants of the Free State: Inventory and identification guide. Strelitzia 38: 114 - 143. South African National Biodiversity Institute, Pretoria. 4Roux, JP. 2003. Swaziland ferns and fern allies. 5Roux, JP. 2012. A revision of the fern genus Dryopteris (Dryopteridaceae) in sub-Saharan Africa. Phytotaxa 70(1): 1 - 118. 6Roux, JP. 2012. Pteridophytes. 31 - 47. South African National Biodiversity Institute, Pretoria. Provided by: Data <table><tbody><tr><th> Habitat</th><td></td><td></td></tr><tr><th> Life Form</th><td></td><td></td></tr><tr><th> IUCN Red List Status</th><td></td><td></td></tr></tbody></table>
http://www.worldfloraonline.org/taxon/wfo-0001111582
Genetic effects of radio-frequency, atmospheric-pressure glow discharges with helium | Applied Physics Letters | AIP Publishing Due to low gas temperatures and high densities of active species, atmospheric-pressure glow discharges (APGDs) would have potential applications in the fields o Genetic effects of radio-frequency, atmospheric-pressure glow discharges with helium Guo Li ; Guo Li 1 Department of Engineering Physics, Tsinghua University , Beijing 100084, People’s Republic of China He-Ping Li ; He-Ping Li a) 1 Department of Engineering Physics, , Beijing 100084, Li-Yan Wang ; Sen Wang Tsinghua University , Beijing 100084, Hong-Xin Zhao Wen-Ting Sun Xin-Hui Xing Cheng-Yu Bao Department of Engineering Physics, Tsinghua University , Beijing 100084, People’s Republic of China Author & Article Information Authors to whom correspondence should be addressed. Electronic addresses: [email protected] and [email protected]. Present address: Department of Mechanical and Aerospace Engineering, Princeton University, D115 E-Quad, Olden Street, Princeton, NJ 08544, USA. Appl. Phys. Lett. 92, 221504 (2008) https://doi.org/10.1063/1.2938692 Article history Received: January 22 2008 Accepted: May 12 2008 Due to low gas temperatures and high densities of active species, atmospheric-pressure glow discharges (APGDs) would have potential applications in the fields of plasma-based sterilization, gene mutation, etc. In this letter, the genetic effects of helium radio-frequency APGD plasmas with the plasmid DNA and oligonucleotide as the treated biomaterials are presented. The experimental results show that it is the chemically active species, instead of heat, ultraviolet radiation, intense electric field, and/or charged particles, that break the double chains of the plasmid DNA. The genetic effects depend on the plasma operating parameters, e.g., power input, helium flow rate, processing distance, time, etc. Topics Ultraviolet light , Biomaterials , Chemical elements , Electrophoresis Atmospheric-pressure glow discharges (APGDs) driven by the radio-frequency (rf) power supply with water-cooled, bare-metallic electrodes, which is the so-called rf APGDs hereafter in this study, show their bright prospects in actual applications compared with low-pressure plasmas with lower capital costs, flexible operations, etc., due to the removal of the complicated and expensive vacuum systems. With the plasma-based sterilization/disinfection, decontamination of biological warfare agents, 1 blood coagulation and living tissue sterilization, 2 etc., as the research background, many papers concerning the biological effects of the APGDs have been published. 1–6 In previously published papers, most of the studies focused on the killing effects of the glow discharges on the cells of the micro-organisms due to the possible inactivation factors, e.g., heat, charged particles, ultraviolet (UV) radiation, chemically active species, intense electric field, or the synergistic actions of the preceding factors. 3–7 However, due to various designed configurations of the plasma generators, different operation conditions, etc., employed by different authors to treat distinct micro-organisms existing in diverse environments, the importance of the foregoing factors may be very different. Thus, it is necessary to investigate the plasma inactivation mechanisms using a certain type of plasma source, including the intracellular changes (e.g., protein denaturalization, inactivation of enzyme, damage to the DNA and chromosome, etc.), the destruction to the cell membrane and/or wall, and the change of the existing environment of the organisms (e.g., the variation of the pH pH values), for promoting the potential applications of the rf APGDs in the biomedical fields. In this letter, the genetic effects of rf APGDs acting on a loopful recombinant plasmid (pP-GFP), which is a covalently closed circle DNA (CCC DNA), are presented at the molecular level, which is important for promoting the actual applications of rf APGD plasmas in the fields of plasma sterilization, gene mutation, etc. The possible factors which may lead to the genetic effects of the rf APGDs under different operation conditions are discussed. The action mechanisms are verified using the matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF) technique with oligonucleotide as the treated material. The schematic diagrams used for studying the characteristics of the cold plasma jet and for the treatment of the biomaterials (e.g., plasmid DNA or oligonucleotide in this study) are illustrated in Figs. 1(a) and 1(b) , respectively. The detailed descriptions on the experimental setup can be referenced to the previous papers. 8,9 In this study, a K-type thermocouple with accuracy of 1 K 1 K is used to measure the temperature of the plasma jet. A probe with biased voltages varying from − 1 to 1 kV − 1 to 1 kV is employed to estimate the concentrations of the charged particles in the plasma jet region. Because the surrounding air engulfed into the plasma jet region will lead to the changes of the concentrations of the active species since the discharge operates in atmosphere, in this paper, a transparent, cylinderlike plastic cap is placed close to the torch nozzle exit in order to reduce the back diffusion effect of air 8 by preventing the entrainment of the surrounding air into the plasma jet region. The small vessels containing the plasmid pP-GFP or oligonucleotide are placed on a horizontal platform, which is fixed on a vertical slider. The stand-off distance between the torch nozzle exit and the vessel, L L ⁠ , can be adjusted by sliding the platform up/down, as illustrated in Fig. 1(b) . FIG. 1. View large Download slide Schematic diagram of the experimental setup. (a) Generation and measurement systems of the rf APGD plasma jet. (b) Experimental setup for treating the biomaterials. FIG. 1. Schematic diagram of the experimental setup. (a) Generation and measurement systems of the rf APGD plasma jet. (b) Experimental setup for treating the biomaterials. The variation of the measured voltage with the rf power input ( P in ) ( P in ) at the helium flow rate Q He = 15 slpm Q He = 15 slpm (standard liters per minute) is shown in Fig. 2 . It shows that the gas ignition occurs at point A with a breakdown voltage V b = 170 ± 4 V V b = 170 ± 4 V and the corresponding averaged rf power input P in = 3 W P in = 3 W ⁠ . Then, the uniform, α α -mode discharge, which is sustained by volumetric ionization processes, 10 sustains with the increase of the power input. Finally, with the further increase of the discharge current, a γ γ -mode discharge, mainly resulting from the ionization by secondary electrons from electrodes, 10 appears at point B with V d = 255 ± 1 V V d = 255 ± 1 V and P in = 169 W P in = 169 W ⁠ . In this study, in order to obtain the uniform, low-temperature glow discharge plasmas which are suitable for the treatment of the biomaterials, the rf power input varies in the range of 10 – 120 W 10 – 120 W ⁠ . The corresponding gas temperatures ( 24 – 64 ° C ) ( 24 – 64 ° C ) on the axis of the plasma jet at 2.0 mm 2.0 mm downstream of the torch nozzle exit with Q He = 25 slpm Q He = 25 slpm are also shown in Fig. 2 as indicated with the shaded area. FIG. 2. Voltage- P in P inand temperature- P in P incharacteristics of the helium rf APGD plasmas. FIG. 2. In this study, 0.75 μ l 0.75 μ l plasmid pP-GFP and 3.0 μ l 3.0 μ l distilled water are injected into a bowl-like, decontaminated plastic vessel. 9 After the DNA is treated by the helium plasma jet, as well as by the hot air or the UV radiation for comparison, it is analyzed on 1.0% agarose gel electrophoresis in 1 × TAE 1 × TAE (Tris-Acetate-EDTA) buffer at 80 V 80 V for 40 min 40 min ⁠ . The agarose gel electrophoresis images of the pP-GFP exposed to the plasma jet under different operation conditions are shown in Fig. 3 , where the “marker” indicates the bp numbers of the DNA fragments, while the “control” represents the untreated plasmid. Normally, the slowest (i.e., the band with the biggest bp number), middle, and fastest (i.e., the band with the smallest bp number) bands represent the double-stranded DNA fragments, the nicked plasmid DNA, and the CCC DNA, respectively. Moreover, since different colors (i.e., changing from dark to gray until disappearance) of the bands in Fig. 3 indicate the relative concentrations of different types of DNA fragments (i.e., the darker a band is, the higher relative concentration of the corresponding DNA fragment would be), most of the DNA in the sample are in the form of CCC DNA because the upper two bands are less dark than that of the fastest band in the lane of the control. The experimental results in Fig. 3 show the following. (1) The rf APGD plasma jet has obvious genetic effects on the plasmid DNA in a short time of 30 s 30 s by breaking the chains of the DNA. Compared with the control, the band of the double-stranded DNA in lane 3 disappears, while the band of the nicked plasmid DAN becomes darker significantly. Moreover, with the increase of the action time ( t ) ( t ) ⁠ , from lane 3 to 7, the color of all the bands becomes light increasingly, which means that more and more DNA chains are broken, and finally in lane 7, almost no bands can be seen indicating that most of the DNA chains have been broken into pieces in 10 min 10 min ⁠ . (2) As indicated in lanes 8–13, with other parameters (e.g., P in P in ⁠ , L L ⁠ , and t t ⁠ ) being unchanged, the genetic effects of the plasma jet on the plasmid DNA become more significant with increasing the helium flow rate, probably due to the increase of fluxes of the chemically active species. (3) With the increase of the rf power input, the genetic effects of the plasma jet become more significant by keeping other parameters being unchanged, as shown in lane 14–21. (4) The agarose gel electrophoresis images in lanes 22–26 show that the genetic effects of the plasma jet become weaker with the increase of the departure distance between the torch nozzle exit and the treated samples ( L ) ( L ) by keeping other parameters being unchanged. FIG. 3. Agarose gel electrophoresis images of the pP-GFP. Lane 1 and 30: marker. Lane 2 and 29: control. Lane 3–7: plasma treatment for 0.5, 1, 3, 5, and 10 min 10 min ⁠, respectively, with Q He = 15 slpm Q He = 15 slpm ⁠, P in = 100 W P in = 100 W ⁠, L = 2.0 mm L = 2.0 mm ⁠. Lane 8–13: plasma treatment for 1.5 min 1.5 minwith P in = 120 W P in = 120 W ⁠, L = 3.0 mm L = 3.0 mm ⁠, and Q He = 5 Q He = 5 ⁠, 10, 15, 20, 25, and 30 slpm 30 slpm ⁠, respectively. Lane 14–21: plasma treatment for 2 min 2 minwith Q He = 25 slpm Q He = 25 slpm ⁠, L = 2.0 mm L = 2.0 mm ⁠, and P in = 10 P in = 10 ⁠, 20, 30, 40, 60, 80, 100, and 120 W 120 W ⁠, respectively. Lane 22–26: plasma treatment for 1.5 min 1.5 minwith Q He = 15 slpm Q He = 15 slpm ⁠, P in = 120 W P in = 120 W ⁠, and L = 2.0 L = 2.0 ⁠, 4.0, 6.0, 8.0, and 10.0 mm 10.0 mm ⁠, respectively. Lane 27: hot air treatment for 10 min 10 minwith the temperature of 80 ° C 80 ° C ⁠; Lane 28: plasma treatment through a quartz glass plate for 1.5 min 1.5 minwith Q He = 15 slpm Q He = 15 slpm ⁠, P in = 120 W P in = 120 W ⁠, and L = 4.0 mm L = 4.0 mm ⁠. The dashed box indicates the DNA bands studied in this paper. FIG. 3. Agarose gel electrophoresis images of the pP-GFP. Lane 1 and 30: marker. Lane 2 and 29: control. Lane 3–7: plasma treatment for 0.5, 1, 3, 5, and 10 min 10 min ⁠, respectively, with Q He = 15 slpm Q He = 15 slpm ⁠, P in = 100 W P in = 100 W ⁠, L = 2.0 mm L = 2.0 mm ⁠. Lane 8–13: plasma treatment for 1.5 min 1.5 minwith P in = 120 W P in = 120 W ⁠, L = 3.0 mm L = 3.0 mm ⁠, and Q He = 5 Q He = 5 ⁠, 10, 15, 20, 25, and 30 slpm 30 slpm ⁠, respectively. Lane 14–21: plasma treatment for 2 min 2 minwith Q He = 25 slpm Q He = 25 slpm ⁠, L = 2.0 mm L = 2.0 mm ⁠, and P in = 10 P in = 10 ⁠, 20, 30, 40, 60, 80, 100, and 120 W 120 W ⁠, respectively. Lane 22–26: plasma treatment for 1.5 min 1.5 minwith Q He = 15 slpm Q He = 15 slpm ⁠, P in = 120 W P in = 120 W ⁠, and L = 2.0 L = 2.0 ⁠, 4.0, 6.0, 8.0, and 10.0 mm 10.0 mm ⁠, respectively. Lane 27: hot air treatment for 10 min 10 minwith the temperature of 80 ° C 80 ° C ⁠; Lane 28: plasma treatment through a quartz glass plate for 1.5 min 1.5 minwith Q He = 15 slpm Q He = 15 slpm ⁠, P in = 120 W P in = 120 W ⁠, and L = 4.0 mm L = 4.0 mm ⁠. The dashed box indicates the DNA bands studied in this paper. In this study, the plasmid pP-GFP is also treated by the hot air with the temperature of 80 ° C 80 ° C for 10 min 10 min ⁠ , as shown in lane 27 of Fig. 3 . By comparing the images of lane 27 and the control, it can be concluded that heat has no contributions to the breaking processes of the DNA chains because of the low temperatures of the plasma jet employed in this paper. In addition, since the plasmid pP-GFP is located in the plasma jet, instead of the discharge region, no intense electric field exists, and the electric probe measurements show that the concentration of the charged particles in the plasma jet region is about 10 8 cm − 3 10 8 cm − 3 ⁠ , which is relatively low. The similar result was also reported by Schütze et al. 11 Thus, the intense electric field and the charged particles also have no contributions to the breaking processes of the DNA chains. Based on the preceding discussions, the most possible factors resulting in the breaks of the plasmid DNA chains are the chemically active species and UV radiation. The emission spectrum of the plasma jet for the case of P in = 110 W P in = 110 W and Q He = 15 Q He = 15 slpm is shown in Fig. 4 . It shows that the intensity of the UV radiation with wavelengths in the 200 – 280 nm 200 – 280 nm range, which has the optimum effects of destroying the DNA, 12 is too low to be detected compared to the intensities of the spectrum of the active species; while the intensities of the helium lines, oxygen atom lines, N 2 N 2 lines, hydroxyl (OH) molecular band ( ⁠ A ∑ + 2 A ∑ + 2 ⁠ , υ = 0 → X 2 Π υ = 0 → X 2 Π ⁠ , υ ′ = 0 υ ′ = 0 ⁠ , 306 – 310 nm 306 – 310 nm ⁠ ) are strong. 13 In addition, by placing a UV-transparent glass upon the samples, the obtained agarose gel electrophoresis image of the plasmid pP-GFP, as shown in lane 28 of Fig. 3 , clearly shows that the UV radiation has little effect on the break of the plasmid DNA chains for the helium rf APGDs. This conclusion is very different from that presented by Trompeter et al. , 14 in which it was concluded that UV radiation played a dominant role in the germ reduction experiments for an argon dielectric barrier discharge because argon is not chemically active. FIG. 4. Emission spectrum of the helium rf APGD plasma jet with P in = 110 W P in = 110 W ⁠, Q He = 15 slpm Q He = 15 slpm ⁠. FIG. 4. Emission spectrum of the helium rf APGD plasma jet with P in = 110 W P in = 110 W ⁠, Q He = 15 slpm Q He = 15 slpm ⁠. For the further validation of the foregoing conclusions, the oligonucleotide with the approximate molecular weight of 3632 is treated by the plasma jet for 3 min 3 min with Q He = 15 slpm Q He = 15 slpm ⁠ , P in = 120 W P in = 120 W ⁠ , and L = 2.0 mm L = 2.0 mm ⁠ . The partial MALDI-TOF mass spectrum of the treated oligonucleotide, also compared with the untreated one, is shown in Fig. 5 , which shows that the helium rf APGD plasma jet can indeed break the oligonucleotide chains into small fragments. The deeper studies concerning the genetic effects of the rf APGDs under different operation parameters of the discharges, different geometrical sizes of the plasma generators, etc., are necessary in the future work. FIG. 5. Partial MALDI-TOF mass spectra for the untreated (a) and treated (b) oligonucleotide by the helium rf APGD plasma jet for 3 min 3 minwith P in = 120 W P in = 120 W ⁠, Q He = 15 slpm Q He = 15 slpm ⁠, L = 2.0 mm L = 2.0 mm ⁠. FIG. 5. Partial MALDI-TOF mass spectra for the untreated (a) and treated (b) oligonucleotide by the helium rf APGD plasma jet for 3 min 3 minwith P in = 120 W P in = 120 W ⁠, Q He = 15 slpm Q He = 15 slpm ⁠, L = 2.0 mm L = 2.0 mm ⁠. This work was supported by the Natural Science Foundation of Beijing (3083021), the National Key Technology R&D Program (2006EP805), the projects sponsored by Beijing Municipal Sciences & Technology Commission (Z07000200540705). REFERENCES 1. H. W. Herrmann , G. S. Selwyn , I. Henins , J. Park , M. Jeffery , and J. M. Williams , IEEE Trans. Plasma Sci. https://doi.org/10.1109/TPS.2002.804196 30 , 1460 ( 2002 ). 2. G. Fridman , A. Shereshevsky , M. M. Jost , A. D. Brooks , A. Fridman , A. Gutsol , V. Vasilets , and G. Friedman , Plasma Chem. Plasma Process. 27 , 163 ( 2007 ). 3. H. W. Herrmann I. Henins J. Park G. S. Selwyn Phys. Plasmas Plasma Processes Polym. 5. S. Ochiai Appl. Phys. Lett. IEEE Trans. Ind. Appl. https://doi.org/10.1109/TIA.2006.870039 J. Appl. Phys. ). 12. M. Laroussi and F. Leipold , Int. J. Mass. Spectrom. https://doi.org/10.1016/j.ijms.2003.11.016 233 , 81 ( 2004 ). 13. S. Y. Moon and Spectrochim. Acta, Part B https://doi.org/10.1016/S0584-8547(02)00259-8 14. F.-J. Trompeter , W. J. Neff , O. Franken , M. Heise , M. Neiger , G. J. Pietsch , and A. B. Saveljew , IEEE Trans. Plasma Sci. https://doi.org/10.1109/TPS.2002.804182
https://pubs.aip.org/aip/apl/article/92/22/221504/120289/Genetic-effects-of-radio-frequency-atmospheric
(PDF) Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women PDF | Abstract Background Iron deficiency (ID) is common in malaria-endemic settings. Intermittent preventative treatment of malaria in pregnancy (IPTp)... | Find, read and cite all the research you need on ResearchGate Associations of maternal iron deficiency with malaria infection in a cohort of pregnant Papua New Guinean women May 2022 Malaria Journal 21(1) DOI: 10.1186/s12936-022-04177-8 License CC BY 4.0 Authors: Abstract and Figures Abstract Background Iron deficiency (ID) is common in malaria-endemic settings. Intermittent preventative treatment of malaria in pregnancy (IPTp) and iron supplementation are core components of antenatal care in endemic regions to prevent adverse pregnancy outcomes. ID has been associated with reduced risk of malaria infection, and correspondingly, iron supplementation with increased risk of malaria infection, in some studies. Methods A secondary analysis was conducted amongst 1888 pregnant women enrolled in a malaria prevention trial in Papua New Guinea. Maternal ID was defined as inflammation-corrected plasma ferritin levels Participant flow chart. CRP, C-reactive protein; AGP, α-1-acid glycoprotein, LM, light microscopy, qPCR, polymerase chain reaction … Figures - available from: Malaria Journal This content is subject to copyright. Terms and conditions apply. Unger etal. Malaria Journal (2022) 21:153 https://doi.org/10.1186/s12936-022-04177-8 RESEARCH Associations ofmaternal iron deciency withmalaria infection inacohort ofpregnant Papua New Guinean w omen Holger W. Unger 1,2,3 , Andie Bleicher 4 , Maria Ome‑Kaius 5 , Elizabeth H. Aitken 6,7 and Stephen J. Rogerson 4,6* Abstract Background: Iron deficiency (ID) is common in malaria‑ endemic settings. Intermittent preventative treatment of malaria in pregnancy (IPTp) and iron supplementation are core components of antenatal car e in endemic regions to prevent adverse pregnancy outcomes. ID has been associated with reduced risk of malaria infection, and correspond‑ ingly, iron supplementation with increased risk of malaria infection, in some studies. Methods: A secondar y analysis was conducted amongst 1888 pregnant women enrolled in a malaria prevention trial in Papua New Guinea. Maternal ID was defined as inflammation‑corrected plasma ferritin levels < 15 μg/L at antenatal enrolment. Malaria burden ( Plasmodium falciparum , Plasmodium vivax ) was determined by light microscopy , polymer‑ ase chain reaction, and placental histology. Multiple logistic and linear regression analyses explor ed the relationship of ID or ferritin levels with indicators of malaria infection. Models were fitted with interaction terms to assess for modifi‑ cation of iron‑malaria relationships by gravidity or treatment arm. Results: Two‑thirds (n = 1226) and 13.7% (n = 258) of women had ID and peripheral parasitaemia, respectively , at antenatal enrolment (median gestational age: 22 weeks), and 18.7% (120/1,356) had evidence of malaria infection on placental histology. Overall, ID was associated with reduced odds of peripheral parasitaemia at enrolment (adjusted odds ratio [aOR] 0.50; 95% confidence interval [95% CI] 0.38, 0.66, P < 0.001); peripheral parasitaemia at delivery (aOR 0.68, 95% CI 0.46, 1.00; P = 0.050); and past placental infection (aOR 0.35, 95% CI 0.24, 0.50; P < 0.001). Corresponding incr eases in the odds of infection were observed with two‑fold increases in ferritin levels. Ther e was effect modification of iron‑ malaria relationships by gravidity. At delivery, ID was associated with r educed odds of peripheral parasitaemia amongst primigravid (AOR 0.44, 95% CI 0.25, 0.76; P = 0.003), but not multigravid w omen (AOR 1.12, 95% CI 0.61, 2.05; P = 0.720). A two‑fold increase in ferritin associated with increased odds of placental blood infection (1.44, 95% CI 1.06, 1.96; P = 0.019) and active placental infection on histology amongst primigravid women only (1.24, 95% CI 1.00, 1.54; P = 0.052). Conclusions: Low maternal ferritin at first antenatal visit was associated with a lower risk of malaria infection during pregnancy, most notably in primigravid women. The mechanisms by which maternal iron stores influence susceptibility to infection with Plasmodium species require further investigation. Trial registr ation Keywords: Iron deficiency, Iron supplementation, Plasmodium falciparum , Plasmodium vivax , Risk Background Malaria in pregnancy continues to be a major global health issue. e principal malaria spec ies infecting preg - nant women are Plasmodium falc iparum and Pla smo - dium viva x . In 2018, approximately 11 million women P . falciparum ) in moderate to high transmission areas in sub-Saharan Africa alone [ 1 ]. A much greater number of pregnancies are at risk of infection when areas of lower transmission are considered, including malaria-endemic settings in the Americas and the Asia–Pacific region, where P . v ivax is often endemic [ 2 ]. Malaria is a principal cause of maternal anaemia and maternal death, causes preterm birth and fetal growth restriction, and increases the risk of fetal loss (miscarriage, stillbirth) and neonatal death [ 3 ]. In sub-Saharan Africa, at least one in five cases of low birth weight (birthweight < 2,500 g) are attribut - able to MIP [ 1 ], and low birth weight infants may be at risk of long-term health sequelae, base d on studies from elsewhere [ 4 ]. A hallmark of P . falciparum infection in pregnanc y is placental sequestration. Infected ery throcytes bind to chondroitin sulphate A present on the surface of the syn - cytiotrophoblast lining the placental intervillous sp ace, thereby avoiding splenic clearance. is process is medi - ated by the parasite antigen V AR2CSA [ 5 ]. If untreated, placental malaria triggers a cascade of inflammator y processes that leads to impairments in placental devel - of moderate to high transmission intensity, women with placental infections are frequently asymptomatic and aparasitaemic, and the risk of placental malaria falls with increasing gravidity [ 5 ]. At least half of placental infections are missed by current point-of-care tests [ 6 ]. Monthly intermittent preventative treatment in preg - nancy (IPTp) with sulfadoxine-pyrimethamine (SP) is currently recommended in malaria-endemic regions of sub-Saharan Africa to treat occult placental infections and provide protection from new infections [ 7 ]. Iron deficiency (ID) in pregnancy is common in malaria-endemic settings. ID is indep endently associated with maternal anaemia, fetal growth restriction and low birth weight [ 8 ]. e Wor ld Health Organization (WHO) recommends routine iron supplementation during preg - nancy in populations with a prevalence of anaemia ≥ 40%, on the proviso that iron supplementation is combined with adequate malaria prevention measures in endemic areas [ 9 ]. is advice is based on concerns over repor ts of increased risk of malaria infec tion in supplemented women and children [ 10 – 14 ]. Correspondingly, ID has been associated w ith reduced risk of malaria infection in cant heterogeneity between studies exists, with a number of studies reporting no association of estimates of mater - nal iron stores or iron supplementation with malaria in pregnancy [ 13 , 19 , 20 ]. Iron supplementation in preg - nancy was not asso ciated with increased risk of malaria infection, including placental infection, in two rand - omized trials in Kenya and Tanzania conducted amongst women concurrently using bed nets and SP-IPTp [ 21 , 22 ]. In Papua New Guinea (PNG), ID in pregnanc y is com - mon in malaria-endemic areas [ 23 , 24 ]: nearly two-thirds of women are iron deficient. Daily iron supplementa - tion in combination with monthly IPT p with SP during pregnancy is national policy. Iron supplementation stud - ies conducted in PNG in the 1980s first highlighted the potential existence of iron-malaria interactions [ 10 , 11 ]. e aim of the present analysis was to determine the relationship of maternal iron deficiency at first antena - tal visit with malaria infection ( P. falciparum and/or P. vivax ) during pregnanc y, and to assess whether these associations are modified by gravidity and malari a pre - vention strategy, in a large cohort of pregnant Papua New A total of 2793 women were randomized to monthly IPT p with SP plus azithromycin (AZ) or a single course of SP plus chloroquine (CQ) at antenatal enrolment in the PNG-IPTp trial (NCT01136850). e details of the trial are described in detail else where [ 25 ]. Drawing on routinely collected samples and data from the PNG-IPTp trial a secondary analysis to a ssess relationships between ID and ferritin levels at antenatal enrolment with malaria infection in pregnancy was conducte d. e analysis con - sidered women who had a singleton live birth (no detect- able congenital anomaly), and for whom data on ferritin levels and peripheral malaria infection at enrolment, and malaria infection at delivery by light microscopy (LM) and quantitative real-time polymerase chain reaction (qPCR) was complete. Study area andpopulation Women in t he PNG-IPTp trial were recruited at clin- ics, health centres, and hospitals loc ated in Madang and Sumkar districts of Madang Province on the North Coast of PNG from 2009–2013, as previou sly described [ 25 ]. e study area is characterized by perennial trans - mission of moderate intensity of both P . falciparum and P . viva x [ 26 ]. Maternal ID and anaemia are common [ 24 , 27 ]. P. f alciparum was the predominant malaria species detected in pregnant women during the study period [ 28 ]. Women wer e screened when attending for their first antenatal visit and enrolled in the parent trial when all inclusion criteria were met and written informed consent was provided. Key inclusion criteria included Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 3 of 11 Unger etal. Malaria Journal (2022) 21:153 an estimated gestational age < 27 week s at first antena- tal visit; singleton pregnanc y; no prior administration of IPT p; and absence of chronic medical conditions in the mother [ 25 ]. e clinical trial and secondary analy - ses relating to maternal malaria infection and anaemia, including the present study, wer e approved by the PNG Institute of Medical Research (PNGIMR) Institutional Review Board (0815), the PN G Medical Research Advi - sory Council (08.01), and the Melbourne Health Human Research Ethics Committee (2008.162). Clinical assessments andsample collection Key demographic and clinical characteristics were deter- mined at enrolment and collected alongside venous blood samples for malariometrics , haemoglobin (Hb) measurements (HemoCue Ltd, Angelholm, Sweden, accuracy 1g/L), and measurement of ferritin and inflam - matory markers [ 24 ]. Women were pr ovided with insec- ticide-treated bed nets and randomi zed 1:1 to monthly IPT p with SP (1500/75 mg) plus AZ (1 g twice daily for 2 days) or a single course of SP plus chloroquine (450 to 600 mg, daily for 3 days) at their first antenatal visit. Iron-folate supplementation (one tablet of ferrous sul - phate 270mg [87.4 mg elemental iron] plus 400 μg folic acid) was offered routinely and women were advised to take one tablet daily. W omen who under went Hb test - ing that identified a Hb ≤ 90 g/L were recommended to take two iron-folate tablets and in addition were provided with albendazole, and treatment response was assess ed a month later . Iron-folate supplementation during preg - nancy was not monitored. Women diagnosed with anae- mia after enrolment were retained in the parent trial, and there was no difference in the prevalence of anaemia at delivery between trial ar ms [ 25 ]. Clinical data and blood samples were also collected when practical at subsequent scheduled and unscheduled antenatal visits . At deliv - ery, when women were able to deliver at a participating health centre or hospital, peripheral and placental blood samples and placental biopsies were taken and Hb was measured again [ 29 ]. Ferritin was measured at enrolment only. Placental blood was collected by incision in the maternal surface of the placenta and aspiration of blood welling from the incision. Laboratory analyses Peripheral and placental blood samples were screened for P . falciparum and P. vivax infection by light micros - copy and polymerase chain reaction (using a duplex qPCR that identified each species) [ 28 ]. Histolog i - cal analysis of placental biopsies was performe d in accordance with established methodology [ 30 , 31 ] and reported as active infection (presence of para sites [acute infection] ± pigment in monocytes and/or fibrin [chronic infection]), past infection (pigment only), and no infection. Maternal iron stores were estimated using ferritin concentrations measured in enrolment plasma by an enzyme-linked immunosorbent assay (ELISA) de vel - oped by our group [ 32 ]. Ferritin is an iron storage pro- tein which is expressed in response to intracellular iron concentrations [ 33 ]. Plasma ferritin reflects overall stor - age iron, can be easily measured, and correlates with reference methods for the diagnosis of ID such as bone marrow aspiration. However, ferritin is an acute phase reactant and plasma levels increase during s ystemic inflammation. T o facilit ate adjustments of ferritin for concurrent inflammation, as recommended by the WHO [ 34 ], concentrations of C-reactive protein (CRP) and α-1- acid glycoprotein (AGP) were measured by ELISA using Human Quantikine ELISA kits (R&D Systems, Minne - apolis, MN, USA). Denitions ID was defined as a plasma ferr itin level < 15μg/L at ante- natal enrolment [ 35 ]. ID and ferritin (transformed to log base 2 [i.e. log 2 ] ferritin for ease of interpretation) were used as exposure measures . Ferritin levels were corrected for inflammation using the ‘internal regression correc - tion’ method devised by Namaste etal. [ 36 ], and adjusted for CRP , AGP , and concurrent malaria parasitaemia [ 21 ]. Additional correction for malaria parasitaemia (infection present or absent according to LM and/or qPCR at the time of ferritin measurement) was considered necessar y as, contrary to findings by Namaste et al., foregoing this would have led to substantial misclassification of iron deficient women as iron replete (i.e. ≥ 15 μg/L) in our cohort: 48.1% of women were classified as ID u sing the standard correction (CRP and AGP), compared to 64.9% when correcting for CRP , AGP and para sitaemia). Inter - nal reference values, i.e. threshold values above which ferritin adjustments are assumed to be required, were 0.2 mg/L and 87 mg/L for C RP and AGP , respectively. Regression coefficients are reported in Additional file 1 . Outcome measures included peripheral malaria infec - tion ( P . falciparum or P. vivax ) by light microscopy and/ or qPCR at enrolment or delivery; placental bloo d infec - tion by light microscopy and/or qPCR; and active or past infection on placental histology [ 29 ]. Statistical analyses Associations of ID or ferritin (log 2 ) at enrolment with indicators of malaria infection at enrolment and delivery were assessed using multiple logistic or linear regre ssion, as appropriate. Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 4 of 11 Unger etal. Malaria Journal (2022) 21:153 Multiple regression adjusted a priori for previously identified predictors of malaria infection in the cohort, including primigravidity, rural residence, maternal age, and trial treatment arm [ 24 , 25 , 29 ]. Models also included gestational age at ferritin measurement as a covariate, to account for physiological depletion of iron stores with advancing gestation. Presence of modification of the association between ID and malar ia infection by gravidity (primigravid versus multigravid) was assesse d by fitting models with interaction terms between ID and gravidity, or between ID and treatment arm. Presence of modifica - tion of the association between ID and malari a infection by enrolment Hb ≤ 90 g/L, a trigger for enhanced iron- folate supplementation, was also assessed for women with complete data. P-values for effect modification were derived from likelihood ratio tests comparing models with and without the interaction terms. A P-value < 0.05 was considered statistically significant. Statistical analy - ses were performed using Stata version 16.0 (StataCorp, College Station, TX, USA). Results e analysis included a total of 1,888 women (Fig. 1 ). e median gestational age at enrolment was 22 ges - tational weeks (interquartile range [IQR] 19, 24 gesta- tional weeks). Nearly half of the women (n = 931) were primigravid, and the median maternal age was 24 years (IQR 20–28 years) (Table 1 ). Approximately two-thirds of women resided in rural areas (n = 1239), and 77% of women reported using a bed net at enrolment. A total of 945 women (50.1%) were randomized to SPAZ, and 943 (49.9%) women were randomized to SPCQ. e mean haemoglobin concentration at enrolment was 97g/L (standard deviation [SD] 15g/L), and 527 of 1,812 women (29.1%) had an enrolment Hb ≤ 90g/L . A total of 1,226 women (64.9%) were classified as ID at antenatal enrolment. e median (IQR) ferritin concentration at first antenatal visit was 10.2μg/L (IQR 5.7–20.4μg/L). Malaria burden A total of 258 women (13.7%) were parasitaemic at ante- natal enrolment. Amongst participants with parasitae- mia, 73.6% (n = 190) had P . falciparum mono-infections, 4.7% (n = 12) had mixed P . falciparum / P . v ivax infections, 20.2% (n = 52) had P . vivax infections , with the remain - der having Plasmodium ovale or Plasmodium malariae infections (n = 4). Half of these infe ctions were submicro - scopic (n = 134) (Table 2 ). At delivery, 6.4% of women (n = 120) had malaria para - sites detected in peripheral blood: among st them 59.2% (n = 71) had P. f alciparum mono-infections, 2.5% (n = 3) had mixed P . falciparum / P. vivax infections, and 38.3% (n = 46) had P . vivax mono-infections . About half of these infections (n = 61) were submicroscopic. Placen - tal blood parasitaemia wa s detected in 5.0% (n = 63) of women with complete data (n = 1253) for these analyses: 87.3% (55/63) of infections were caused by P . falciparum (Ta ble 2 ). Placental histology data wa s available for 1,356 study participants. Evidence of infection was detec ted in 254 (18.7%) of women: amongst them, 40.6% (103/254) had active placental malaria, and 59.4% (151/254) had evidence of past infection (Table 2 ). One fifth of women (21.4%, 369/1723) had a Hb ≤ 90g/L at delivery . Associations ofmaternal iron stores andmalaria infection duringpregnancy Associations between malar ia infection during pregnancy and maternal ID at first antenatal visit are presented in T able 3 . ID at antenatal enrolment was associated with reduced odds of concurrent peripheral malaria para si - taemia (adjusted odds ratio [aOR] 0.50; 95% confidence interval [95% CI] 0.38, 0.66, P < 0.001) (T able 3 ). Specifi - cally, women with ID had reduced odds of P . falciparum infection (aOR 0.35, 95% CI 0.26, 0.49; P < 0.001) but not P . viva x infection at enrolment (aOR 1.76, 95% CI 0.91, 3.41; P = 0.093) (Ta ble 2 ). W omen w ith ID had more markedly reduced odds of microscopic (aOR 0.30, 95% CI 0.21, 0.46; P < 0.001) than submicroscopic infection (aOR 0.74, 95% CI 0.51, 1.07; P = 0.11) (T able 2 ). For a two-fold increase in ferritin, there was a 37% increase in the odds of peripheral parasitaemia at first antenatal visit (aOR 1.37; 95% CI 1.23, 1.53, P < 0.001) (T able 3 ). At delivery, when peripheral parasitaemia was less common and proportionally included more P . v ivax infections, iron-deficient women had reduced odds of peripheral blood infection (aOR 0.68, 95% C I 0.46, 1.00; P = 0.050). Women with ID had reduced odds of periph - eral P. fa lciparum infection (aOR 0.77, 95% CI 0.47, 1.27; P = 0.31) and peripheral P . vivax infe ction (aOR 0.55, 95% CI 0.30, 1.02, P = 0.058) (T able 2 ). Women with ID had reduced odds of peripheral submicroscopic (aOR 0.48, 95% CI 0.28, 0.82; P = 0.008) but not microscopic infec - tion (aOR 0.97, 95% CI 0.55, 1.70; P = 0.91) ( T able 2 ). A two-fold increase in ferritin associated w ith increased odds of peripheral parasitaemia at deliver y (aOR 1.22, 95% CI 1.10, 1.49, P = 0.001; Table 3 ). e majority of placental blood infections were caused by P . falciparum (T able 2 ). W omen with ID had reduced odds of placental blood infections (aOR 0.66, 95% 0.39, 1.44; P = 0.14); and a correspond - ing increase in odds of placental infection asso ciated with a two-fold increase in ferritin (aOR 1.22, 95% CI 1.00, 1.49; P = 0.054) (T able 3 ). Amongst women w ith histology data, ID at first antenatal visit was ass oci - ated with reduced odds of past placental infection at delivery (aOR 0.35, 95% CI 0.24, 0.50; P < 0.001) but Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 5 of 11 Unger etal. Malaria Journal (2022) 21:153 not with active placental infection (aOR 0.91; 95% CI 0.58, 1.43; P = 0.68) (Table 3 ). ese findings were reciprocated in analyses that assessed the relationship between ferritin levels and malari a infection at deliv - ery, with two-fold increases in ferritin levels associ at - ing with increased odds of pa st infection detected at delivery but not active infection on placental histology (Ta ble 3 ). However, analyses of associations between ID and active placental infections that assessed subsets of active infection, e.g. acute infection (para sites, no pig - ment in monocytes or fibrin) or chronic infection (par - asites, pigment in monoc ytes and/or fibrin), indicated reduced odds of chronic placental infection amongst iron-deficient women (T able 2 ). Sensitivity analyses were conducted to assess ass ocia - tions between ID and malaria after (a) adjusting ferr i - tin levels for CRP and AGP , but not concurrent malaria infection; and (b) excluding women with malaria Fig. 1 Participant flow chart. CRP, C‑reactive protein; A GP , α‑1‑acid glycoprotein, LM, light microscopy, qPCR, polymerase chain reaction Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 6 of 11 Unger etal. Malaria Journal (2022) 21:153 parasitaemia at enrolment. e findings were very simi - lar to those presented above (Additional file 1 : Tables S1, 2). Impact ofgravidity ortreatment arm ontherelationship betweenantenatal ID andmalaria infection atbirth Associations of ID or ferritin levels with malar ia infec - tion at delivery were modified by gravidity (Additional file 1 : Tables S3). ID was associated with reduced odds of peripheral parasitaemia at birth amongst primi - gravid (peripheral parasitaemia: AOR 0.44, 95% C I 0.25, 0.76; P = 0.003) but not multigra vid women (peripheral parasitaemia: AOR 1.12, 95% CI 0.61, 2.05; P = 0.72) (Additional file 1 : T ables S3). This find - ing was corroborated by a reciprocal increas e in the odds of peripheral infection asso ciated with a two-fold increase in ferritin amongst primigravid (aOR 1.51, 95% CI 1.23, 1.84; P < 0.001), but not among st multi - gravid women (aOR 1.04, 95% CI 0.83, 1.29); P = 0.76). Likewise, assoc iations of ferritin levels with placental blood infection and acute infection on histolog y dif - fered by gravidity status. A two-fold increase in ferri - tin associated with increase d odds of placental blood infection (aOR 1.44, 95% CI 1.06, 1.96, P = 0.019) and acute placental infection (aOR 1.24, 95% CI 1.00, 1.54; 0.052) amongst primigravid women only, with corresponding trends observed when I D was used to describe maternal iron stores (Additional file 1 : Tables S3). There was no evidence of effect modification of iron-malaria associations by malaria prevention reg i - men (Additional file 1 : Tables S4) or enrolment Hb of ≤ 90 g/L , a trigger for enhanced iron-folate supple - mentation (Additional file 1 : T ables S5). Discussion e present study was conducted in a P . falciparum and P . viva x co-endemic setting of moderate transmis - sion intensity. P eripheral blood malaria infection wa s detected in approximately 15% of women at their first antenatal visit and 6% at birth, and 19% of women had evidence of malaria infection on placental histology. e predominant malaria species infecting preg nant women was P . falciparum (80% of peripheral infections before study interventions and 60% at delivery, i.e. after drug allocation). ID, defined as an inflammation and infection-corrected ferritin level < 15 μg/L at first ante - natal visit, was asso ciated with reduced odds of periph - eral infection at enrolment; reduced odds of peripheral and placental blood infection at birth; and reduced risk of past infection on placental histology. At ante - natal enrolment, when the highest burden of periph - eral infection was detected, ID w as associated with a substantially reduced odds of P. fa lciparum , but not P. vivax infection, and a more pronounced decrea se in microscopic than in submicroscopic infections. By con - trast, ID was asso ciated with reduced odds of periph - eral P . v ivax infection and submicroscopic infection at delivery. Associations between indicators of maternal iron stores and malaria infection at delivery were modi - fied by gravidity. Amongst primigravid women only, there were increased odds of malaria infection (p eriph - eral and placental blood infection, active infection on Table 1 Association of malaria infection at first antenatal visit with maternal socio‑demographic charac teristics, Madang, Papua New Guinea, 2009–2013 Mean [standard deviation]; or median (interquartile range); or N (%). Malaria infection at rst antenatal visit was dened as presence of Plasmodium spp. detected by light microscopy and/or qPCR of peripheral blood a Data available for 1812 women (245 women with malaria infection) Characteristic All women (n = 1888) Malaria infection (n = 258) No malaria infection (n = 1630) Gestational age (weeks) 22 (19, 24) 21 (18, 24) 22 (20, 24) Maternal age (years) 24 (20, 28) 23 (20, 27) 24 (20, 28) Residence Rural 1239 (65.6) 204 (79.1) 1035 (63.5) Urban/peri‑urban 649 (34.4) 54 (20.9) 595 (36.5) Gravidity Primigravid 931 (49.3) 139 (53.9) 792 (48.6) Multigravid 957 (50.7) 119 (46.1) 838 (51.4) Bed net use Yes 1453 (77.0) 199 (77.1) 1254 (76.9) No 435 (23.0) 59 (22.9) 376 (23.1) Haemoglobin (g/L) a 97 (15) 92 (16) 98 (14) Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 7 of 11 Unger etal. Malaria Journal (2022) 21:153 histology) associated with a two-fold increa se in fer - ritin, and reduced odds of peripheral infection a ssoci - ated with ID. Collectively, these data provide further evidence in support of previously rep orted associations of indicators of maternal iron stores and the occurrence of peripheral and placental malaria infection during pregnancy [ 13 , 16 – 18 , 37 , 38 ]. e data further suggest that associations may differ by parasite species, and are more pronounced when peripheral infections detect - able by microscopy were considered. How does an iron-replete state (or supplementation) increase the risk of malaria infection? Suppressed er yth - ropoiesis in women with ID anaemia was asso ciated with reduced growth rates of P . falciparum parasites in vitro, whilst their growth was enhanced in response to iron supplementation and consequential elevated erythro - poiesis [ 39 , 40 ]. D epleted antenatal iron stores were Table 2 Malaria infection at first antenatal visit and at birth, by presence or absence of iron deficiency (plasma ferritin), Madang, Papua New Guinea, 2009–2013 N (%). Analyses adjusted for gravidity, maternal age, malaria chemoprev ention regimen, rural location, and gestational age at ferritin measurement. Ferritin levels were adjusted for concurrent inammation and peripheral Plasmodium parasitaemia using the BRINDA (Biomarkers Reecting Inammation and Nutritional Determinants of Anemia) approach [ 36 ] aOR: adjusted odds ratio; CI: condence interval; P: Plasmodium a Mixed P . falciparum / P. viv ax infections were included in regressions models as P . falciparum infections b Includes 55 P. falciparum inf ections, 1 mixed P . falciparum / P. viv ax infection, and 7 P. viv ax infections All women Iron-decient (ferritin < 15μg/L) I ron-replete (ferritin ≥ 15μg/L) aOR (95% CI) P value First antenatal visit Parasite detection n = 1888 n = 1226 n = 662 Microscopic 124 (6.6) 47 (3.8) 77 (11.6) 0.30 (0.21, 0.46) < 0.001 Submicroscopic 134 (7.1) 76 (6.2) 58 (8.8) 0.74 (0.51, 1.07) 0.11 No infection 1630 (86.3) 1103 (90.0) 527 (79.6) Reference Plasmodium species P . falciparum 190 (10.1) 76 (6.2) 114 (17.2) 0.35 (0.26, 0.49) < 0.001 P . falciparum / P. vivax a 12 (0.6) 6 (0.5) 6 (0.9) P . vivax 52 (2.8) 39 (3.2) 13 (2.0) 1.76 (0.91, 3.41) 0.093 P . malariae/ovale 4 (0.2) 2 (0.2) 2 (0.3) – No infection 1630 (86.3) 1103 (90.0) 527 (79.6) Reference Delivery Peripheral infection n = 1888 n = 1226 n = 662 Parasite detection Microscopic 59 (3.1) 36 (2.9) 23 (3.5) 0.97 (0.55, 1.70) 0.91 Submicroscopic 61 (3.2) 30 (2.5) 31 (4.7) 0.48 (0.28, 0.82) 0.008 No infection 1768 (93.6) 1160 (94.6) 608 (91.8) Reference Plasmodium species P . falciparum 71 (3.8) 40 (3.3) 31 (4.7) 0.77 (0.47, 1.27) 0.31 P . falciparum / P. vivax a 3 (0.2) 3 (0.2) 0 (0.0) – P . vivax 46 (2.4) 23 (1.9) 23 (3.5) 0.55 (0.30, 1.02) 0.058 No infection 1768 (93.6) 1160 (94.6) 608 (91.8) Reference Placental infection (blood) n = 1253 n = 817 n = 436 Parasite detection b Microscopic 40 (3.2) 24 (2.9) 16 (3.7) 1.00 (0.51, 1.99) 0.99 Submicroscopic 23 (1.8) 8 (1.0) 15 (3.4) 0.33 (0.13, 0.83) 0.018 No infection 1190 (95.0) 785 (96.1) 405 (92.9) Reference Placental infection (histology) n = 1356 n = 893 n = 463 Acute 53 (3.9) 40 (4.5) 13 (2.8) 1.62 (0.83, 3.16) 0.16 Chronic 50 (3.7) 26 (2.9) 24 (5.2) 0.54 (0.30, 0.99) 0.047 Past 151 (11.1) 72 (8.1) 79 (17.1) 0.35 (0.24, 0.51) < 0.001 No infection 1102 (81.3) 755 (84.6) 347 (75.0) Reference Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 8 of 11 Unger etal. Malaria Journal (2022) 21:153 associated with reduced odds of P. vivax infection at delivery but not at enrolment. ID decreases pro duction of reticulocytes , which P . viva x preferentially infects, so a protective effect might be envisaged. In addition to ery th - ropoiesis-mediated impacts of ID on para site growth, other mechanisms may be of relevance to iron-malaria interactions. ough ID may decrease susceptibility to disease it is worth acknowledging that it may also have a negative effect of the development of immunity. ID at the time of vaccination in young children is associated with decreased antibody to diphtheria , pertussis, and pneumococcal vaccines [ 41 ], and serum iron is positively associated with measles antibo dy titres in vaccinated individuals [ 42 ]. Experiments in animal models and in vitro suggest that ID cause s defective B-cell prolif - eration and differentiation [ 42 ]. is is corroborated by recent reports of reduced levels of P. falciparum -specific antibodies in iron-deficient African children [ 43 ]. ID may thus affect the development and functionality of antibody features that can protect from malaria infection [ 44 ]. e size and the directionality of effects obser ved in our study were consistent with previous studies that assessed assoc iations between ferritin and P . falcipa - rum infection in pregnant women [ 13 ]. ID may hamper the development of immunity to pregnancy-associated malaria that translates into lower prevalence of placen - tal infection and associated adverse bir th outcomes in high transmission settings. In addition, ID may exert a protective effect in primigravid women by slowing para - site growth. In the present study, gravidity-dependent differences in associations of ID with malaria infection during pregnancy were obser ved. ID was associated with reduced odds of peripheral parasit aemia at delivery amongst primigravid women, and a two-fold increase in ferritin associated with malaria infe ction in primigravid but not multigravid women. Similar observations were made in earlier research from T anzania. Iron-deficient primi- and secundigravidae had a lower prevalence of placental blood P . falciparum infection by light micros - copy compared to their iron-replete counterparts. Amongst multigravidae, malaria prevalence did not dif - fer significantly between iron-deficient and iron-replete women [ 16 ]. ese data suggest that the development of gravidity-dependent protective immunity to placen - tal infection [ 45 ] may modify the relationship between maternal ID and malaria protection. Malaria prevention approaches may also alter the association of ID and iron supplementation with malaria infection risk in pregnant women [ 20 , 46 ]. In the present study, two mark edly dif - ferent malaria prevention approaches (a single dose of SPCQ at antenatal enrolment versus monthly IPT p with SPAZ) were used alongside insecticide treated bed nets,. However, there was no apparent effect modifica - tion of iron-malaria relationships by treatment arm. is suggests that in PNG both treatment regimens did not substantially alter malaria risk related to maternal iron stores. A 2014 meta-analysis exclusively reported iron-malaria interactions when CRP-corrected ferritin levels, but not other markers, were used to determine maternal iron stores [ 13 ]. It may be that the effect of malaria-associ - ated inflammation is not fully captured by CRP and AGP [ 47 ], which could confound the observed iron-malaria relationships. Whilst previous research, conducted in non-pregnant individuals, indicated a limite d role of further correcting ferritin levels by concurrent malaria Table 3 Association of maternal iron status (ferritin) with malaria infection at antenatal enrolment and at delivery, Madang, Papua New Guinea, 2009–2013 Analyses adjusted for gravidity, maternal age, malaria chemoprev ention regimen, rural location, and gestational age at ferritin measurement. Ferritin levels were adjusted for concurrent inammation and peripheral malaria parasitaemia using the BRINDA (Biomarkers Reecting Inammation and Nutritional Determinants of Anemia) approach [ 36 ] aOR: adjusted odds ratio; CI: condence interval a Include 1,886, 1,886, 1,253 and 1,356 women with malaria infection data ( Plasmodium falciparum , P . vivax ) from peripheral blood at enrolment, peripheral blood at delivery, placental blood, and placental histology collected at delivery, respectively Factor aOR (95% CI) P value Enrolment Peripheral infection a Iron deficiency Ferritin < 15 μg/L 0.50 (0.38, 0.66) < 0.001 Ferritin ≥ 15 μg/L Reference Log 2 (ferritin) 1.37 (1.23, 1.53) < 0.001 Delivery Peripheral infection a Iron deficiency Ferritin < 15 μg/L 0.68 (0.46, 1.00) 0.050 Ferritin ≥ 15 μg/L Reference Log 2 (ferritin) 1.27 (1.10, 1.48) 0.001 Placental infection (blood) a Iron deficiency Ferritin < 15 μg/L 0.66 (0.39, 1.14) 0.14 Ferritin ≥ 15 μg/L Reference Log 2 (ferritin) 1.22 (1.00, 1.49) 0.054 Placental infection (histology) a Iron deficiency Active infection 0.91 (0.58, 1.43) 0.68 Past infection 0.35 (0.24, 0.50) < 0.001 No infection Reference Log 2 (ferritin) Active infection 1.04 (0.88, 1.22) 0.64 Past infection 1.65 (1.42, 1.91) < 0.001 No infection Reference Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 9 of 11 Unger etal. Malaria Journal (2022) 21:153 parasitaemia [ 36 ], foregoing correction of ferritin for both inflammation (CRP , AGP) and concurrent per iph - eral parasitaemia would have resulted in misclassification of 25% of women as iron replete in the present cohort, which prompted a primary analysis using ferritin levels corrected for both inflammation and malaria infection. However, associations between maternal ID or ferritin levels with malaria infection were highly comparable in analyses using ferritin levels corrected for C RP and AGP only (Additional file 1 : T ables S1), and analyses using fer - ritin corrected for CRP , AGP and concurrent peripheral parasitaemia (Table 3 ). is suggest s that correcting for presence of peripheral parasitaemia present at ferritin measurement has a limited role in confounding asso - ciations of ID and subsequent malaria infection during pregnancy, but may help with estimating true burden of ID in pregnancy. Mwangi et al. performed a similar analysis in Kenya, and showed that adjusting for CRP , AGP and parasitaemia gave a better fit for their model to predict ID [ 21 ]. Whether placental infections without detectable blood stream infection [ 48 ] affect fer ritin lev - els is unknown, as is whether such occult infections are associated with increases in ferr itin levels that are not captured by adjustment for CRP or AGP . More recent reports of associ ations between other markers of iron stores (transferrin saturation, soluble transferrin recep - tor [sTFR]/log 10 ferritin ratios) and malaria in pregnant women and children [ 37 , 49 ] support the notion of a true biological effect. is is f urther consolidated by prospec - tive studies reporting increased ri sk of malaria infection in pregnant women and children receiving iron supple - ments in absence of concurrent anti-malarial chemopre- vention [ 12 , 46 ]. Howe ver , trials have demonstrated that iron supplementation in pregnancy is safe when IPTp- SP and bed nets are used concurrently [ 20 , 22 ]. e strengths of the present research include compre - hensive assessments of infection status in a large cohort of pregnant women at risk of both P . falciparum and P. vivax infection; adjustments of ferritin le vels for con - current inflammation and peripheral parasitaemia; and adjustments for potential confounders including mater - nal residence, a marker of infection exposure risk. Weak- nesses include that the provision and uptake of iron supplementation was unmonitored and may have differed between iron deficient and iron replete women. Further - more, residual confounding of ferritin-malaria interac- tions by the presence of subpatent placental infections at the time of ferritin measurement could not be ruled out. Conclusions ere are substantial associations between mark - ers of antenatal iron status and malaria infection dur - ing pregnancy. Whilst residual confounding due to misclassification of ID and unmeasured predictors of malaria infection cannot be rule d out, maternal iron status may influence malaria risk by altering parasite growth potential and maternal immune responses to malarial infection, including placental malaria. Pro - spective studies that assess the temporal relationships between pre-pregnanc y and early pregnancy iron stores and iron supplementation during pregnancy with malaria incidence and the development of anti-malar - ial immunity could consolidate our understanding of iron-malaria relationships in pregnancy, alongside eval - uations of the impact of placental infection on mark - ers of maternal iron status. Broader validation of the approach to adjust ferritin levels for both inflammation and Plasmodium infection ag ainst reference methods to diagnose ID, such as bone marrow iron stores, are desirable in the future. Abbreviations AGP: α‑1‑Acid glycoprotein; CI: Confidence interval; CRP: C‑reactive protein; Hb: Haemoglobin; ID: Iron deficiency; IPTp: Intermittent preventive treatment in pregnancy; IQR: Interquartile range; OR: Odds ratio; PNG: Papua New Guinea; PCR: Polymerase chain reaction; SD: Standard deviation. Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1186/ s12936‑ 022‑ 04177‑8 . Additional le1: TableS1. Association of maternal ferritin levels at antenatal enrolment with malaria infection at antenatal enrolment and at delivery, Madang, Papua New Guinea, 2009–2013. Ferritin levels were adjusted for concurrent inflammation (C‑reactive protein and α‑1‑acid glycoprotein). TableS2. Association of f erritin levels at antenatal enrol‑ ment with malaria infection at delivery in women without peripheral Plasmodium parasitaemia at antenatal enrolment, Madang, Papua New Guinea, 2009–2013. Ferritin levels were adjusted for concurrent inflamma‑ tion (C‑reactive protein and α‑1‑acid glycoprotein). T ableS3. Associations between maternal iron status (ferritin) at first antenatal visit and malaria infection at delivery, stratified by gravidity, Madang Province, P apua New Guinea, 2009–2013. TableS4. Associations between maternal iron status (ferritin) at first antenatal visit and malaria infection at delivery, stratified by malaria prevention regimen, Madang Province, P apua New Guinea, 2009–2013. TableS5. Associations between maternal iron status (ferritin) at first antenatal visit and malaria infection at delivery, stratified by hae‑ moglobin status at antenatal enrolment, Madang Province, Papua New Guinea, 2009–2013. Acknowledgements We thank the participating women and their families; the PNG IMR clinical, administrative, logistics, and laboratory staff; staff at all participating health centres; Dr Valentina Laurita Longo; and Dr . Regina Wangnapi. Author contributions SJR, HWU, and EA conceived and designed the study. MOK, HWU, and SJR supervised enrolment and follow‑up of patients. EA, AB, and SJR supervised and conducted laboratory procedures. HWU, AB, MOK, EA and SJR verified, analysed, and interpreted the data. HWU drafted the original version of the manuscript. All authors participated in the writing of the manuscript. All authors read and approved the final manuscript. Content courtesy of Springer Nature, terms of use apply. Rights reserved. Page 10 of 11 Unger etal. Malaria Journal (2022) 21:153 Funding The present study was funded by a research grant from the British Maternal and Fetal Medicine Society (BMFMS) to HWU. The parent trial was supported by the Malaria in Pregnancy Consortium (funded by the Bill & Melinda Gates Foundation, 46099), and the Pregvax Consortium (European Union’ s Seventh Framework Programme FP7‑2007‑HEAL TH, PREGVAX 201588, and the Spanish Government EUROSALUD 208 Programme). This work was also supported by the National Health and Medical Research Council of Australia (Australian Centre of Research Excellence in Malaria Elimination ‑ACREME) grant 1134989. Funding sources did not have any involvement in the study desig n; collection, analysis, and interpretation of data; and compilation and submission of this report. Availability of data and materials Data are available from the WW ARN data repository ( http:// www. wwarn. org/ worki ng‑ toget her/ shari ng‑ data/ acces sing‑ data ) for researchers who meet the criteria for access to confidential data and from the corresponding author on reasonable request. Declarations Ethics and approvals and consent to participate The study was approved by the PNG Institute of Medical Research (PNGIMR) Institutional Review Board (0815), the PNG Medical Research Advisory Council (08.01), and the Melbourne Health Human Research Ethics Committee (2008.162). The study was conducted in accordance with Good Clinical Prac‑ tice guidelines (ICH GCP E6). All women provided written informed consent. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Author details 1 Department of Obstetrics and Gynaecology, Royal Darwin Hospital, Darwin, NT, Australia. 2 Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia. 3 Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liv erpool, UK. 4 Depar tment of Medicine (RMH), Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia. 5 Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea. 6 Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia. 7 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Mel‑ bourne, Melbourne, VIC, Australia. Received: 9 December 2021 Accepted: 7 May 2022 References 1. WHO. World Malaria Report 2019. Geneva: World Health Organization; 2019. 2. Dellicour S, Tatem AJ, Guerra CA, Snow RW, ter Kuile FO . Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study. PLoS Med. 2010;7: e1000221. 3. Rogerson SJ, Unger HW. Prevention and control of malaria in preg‑ nancy ‑ new threats, new opportunities? Expert Rev Anti Infect Ther. 2017;15:361–75. 4. Barker DJ. The developmental origins of adult disease. Eur J Epidemiol. 2003;18:733–6. 5. Rogerson SJ, Desai M, Mayor A, Sicuri E, Taylor SM, van Eijk AM. Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. Lancet Infect Dis. 2018;18:e107–18. 6. Umbers AJ, Unger HW, Rosanas‑Urgell A, Wangnapi RA, Kattenberg JH, Jally S, et al. Accuracy of an HRP‑2/panLDH rapid diagnostic test to detect peripheral and placental P lasmodium falciparum infection in Papua New Guinean women with anaemia or suspected malaria. Malar J. 2015;14:412. 7. WHO. Policy brief for the implementation of intermittent preventive treatment in malaria in pregnancy using sulfadoxine‑pyrimethamine (IPTp‑SP) (January 2014). Geneva: World Health Organization; 2014. 8. Iqbal S, Ekmekcioglu C. Maternal and neonatal outcomes related to iron supplementation or iron status: a summary of meta‑analyses. J Matern Fetal Neonatal Med. 2019;32:1528–40. 9. WHO. Recommendations on antenatal care for a positive pregnancy experience. Geneva: World Health Organization; 2016. 10. Oppenheimer SJ, Gibson FD, Macfarlane SB, Moody JB, Harrison C, Spen‑ cer A, Bunari O. Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea. Trans R Soc Trop Med Hyg. 1986;80:603–12. 11. Oppenheimer SJ, Macfarlane SB, Moody JB, Harrison C. Total dose iron infusion, malaria and pregnancy in Papua New Guinea. T rans R Soc Trop Med Hyg. 1986;80:818–22. 12. Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, Dutta A, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community‑based, randomised, placebo‑ controlled trial. Lancet. 2006;367:133–43. 13. Sangare L, van Eijk AM, T er Kuile FO, Walson J, St ergachis A. The associa‑ tion between malaria and iron status or supplementation in pregnancy: a systematic review and meta‑analysis. PLoS ONE. 2014;9: e87743. 14. Georgieff MK, Krebs NF, Cusick SE. The benefits and risks of iron supple‑ mentation in pregnancy and childhood. Annu Rev Nutr. 2019;39:121–46. 15. Moya‑Alvarez V, Cottrell G, Ouedraogo S, Accr ombessi M, Massoug‑ bodgi A, Cot M. High iron levels are associated with increased malaria risk in infants during the first year of life in Benin. Am J Tr op Med Hyg. 2017;97:497–503. 16. Kabyemela ER, Fried M, Kurtis JD, Mutabingwa TK, Duffy PE. Decreased susceptibility to P lasmodium falciparum infection in pregnant women with iron deficiency. J Infect Dis. 2008;198:163–6. 17. Bahizire E, D’Alessandro U , Dramaix M, Dauby N, Bahizire F , Mubagwa K, Donnen P . Malaria and iron load at the first antenatal visit in the rural South Kivu, Democratic Republic of the Congo: is iron supplementation safe or could it be harmful? Am J Tr op Med Hyg. 2018;98:520–3. 18. Senga EL, Harper G, Koshy G, Kazembe PN, Brabin BJ. Reduced risk for placental malaria in iron deficient women. Malar J. 2011;10:47. 19. Penarosas JP , Deregil LM, Garciaasal MN, Dowswell T. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015;7:CD004736. 20. Mwangi MN, Roth JM, Smit MR, Trijsburg L, Mwangi AM, Demir A Y, et al. Effect of daily antenatal iron supplementation on Plasmodium infection in Kenyan women: a randomized clinical trial. JAMA. 2015;314:1009–20. 21. Mwangi MN, Echoka E, Knijff M, Kaduk a L, Werema BG, Kinya F M, et al. Iron status of Kenyan pregnat women after adjusting for inflammation using BRINDA regression analysis and other correction methods. Nutri‑ ents. 2019;11:420. 22. Etheredge AJ, Premji Z, Gunaratna NS, Abioye AI, Aboud S, Dug‑ responses. Nat Commun. 2019;10:2935. 43. Bundi CK, Nalwoga A, Lubyayi L, Muriuki JM, Mogire RM, Opi H, et al. Iron deficiency is associated with reduced levels of Plasmodium falciparum ‑ specific antibodies in African children. Clin Infect Dis. 2021;73:43–9. 44. Aitken EH, Damelang T, Ortega‑Pajares A, Alemu A, Hasang W, Dini S, et al. Developing a multivariate prediction model of antibody features associ‑ ated with protection of malaria‑infected pregnant women from placental malaria. Elife. 2021;10:e65776. 45. Ndam NT, Denoeud‑Ndam L, Doritchamou J, Viwami F , Salanti A, Nielsen MA, et al. Protective antibodies against placental malaria and poor out‑ comes during pregnancy. Benin Emerg Infect Dis. 2015;21:813–23. 46. Nacher M, McGready R, Stepniewska K, Cho T, Looareesuwan S, White NJ, Nosten F . Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy. T rans R Soc Trop Med Hyg. 2003;97:273–6. 47. Barffour MA, Schulze KJ, Coles CL, Chileshe J, Kalungwana N, Siamusantu W, et al. Malaria exacerbates inflammation‑associated elevation in fer‑ ritin and soluble transferrin receptor with only modest effects on iron deficiency and iron deficiency anaemia among rural Zambian children. Trop Med Int Health. 2018;23:53–62. 48. Anchang‑Kimbi JK, Achidi EA, Nkegoum B, Sverremark‑Ekstrom E, Troye‑ Blomberg M. Diagnostic comparison of malaria infection in peripheral women. Malar J. 2009;8:126. 49. Muriuki JM, Mentzer AJ, Kimita W, Ndungu FM, Macharia AW , Webb EL, et al. Iron status and associated malaria risk among African children. Clin Infect Dis. 2019;68:1807–14. Publisher’ s Note ... In addition to the dietary resources, one needs to be aware of the geographical regions before providing iron. For example, health professionals may need to treat malaria in areas with endemic malaria while providing iron therapy to women [67] . Similarly, iron may also be affected by worm infestation. ... Role of iron in the reduction of anemia among women of reproductive age in low-middle income countries: insights from systematic review and meta-analysis Article Full-text available BMC Wom Health Aziz Savera
https://www.researchgate.net/publication/360881253_Associations_of_maternal_iron_deficiency_with_malaria_infection_in_a_cohort_of_pregnant_Papua_New_Guinean_women
Portrait of an Unknown Lady: Technical Analysis of an Early Tudor Miniature | Article index | Articles | British Art Studies An online, open-access and peer-reviewed academic journal for research on all aspects of British art, architecture and visual culture. ArticlebyPolly Saltmarsh Lucas Horenbout, Portrait of an Unknown Lady (detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Abstract Portrait of an Unknown Lady Introduction This intriguing portrait of an unknown woman forms part of the collection of early miniatures at the Yale Center for British Art (YCBA) ( Fig. 1 DOI Figure 1.Lucas Horenbout, Portrait of an Unknown Lady, circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59).Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). 1 His father Gerard was a celebrated painter in Flanders and worked for Margaret of Austria before coming to England. In October 1528, Gerard was employed by Henry VIII at the Tudor court where he received a regular monthly wage as “painter” until 1531. 2 Gerard’s daughter Susanna is also present and, in some accounts, it is claimed that Henry VIII actively sought her into his employ and that she may have been the first of the Horenbout family to come to England. 3 Levina Teerlinc was the daughter of Simon Bening, the most celebrated illuminator working in Flanders at the height of Flemish manuscript patronage and production at the turn of the sixteenth century. 4 Teerlinc arrived in Britain in around 1545 with her husband George and their life at court can be traced through the accounts of the New Year’s gift lists. Teerlinc is referred to in the lists as both a “ paintrix 5 6 It also highlights the fact that payments were sometimes made to the husband of a woman at court rather than directly to her, making the references to commissions or work undertaken harder to trace. Portrait of an Unknown Lady was purchased by Paul Mellon as a pair with the Portrait of a Man , sold by Sotheby’s London, on 1 June 1970 from the collection of Miss Dorothy Hutton ( Fig. 2 Portrait of a Man is now unquestioningly given to Holbein. Recent research has established that the sitter is likely to be Sir George Carew based on the resemblance to a drawing by Holbein and firmly situates the work within his oeuvre. Strong attributed the miniature of an Unknown Lady 7 DOI Figure 2.Hans Holbein the Younger, Portrait of a Man, probably Sir George Carew, circa 1540, watercolour on vellum, 6.7 × 5.7 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.58).Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). This paper starts with the object as its point of departure to explore these questions. By examining the materials and techniques used in creating this portrait, it can be compared to other early miniatures and placed into context ahead of a discussion of its possible attribution and the identification of the sitter. The examination of early miniatures inevitably requires revisiting the well-trodden ground of the development of the portrait miniature from the established illumination workshops across Europe to its place as a prized art form at the Tudor court. However, in this context it is crucial to understand the limnings produced by the artists working within both these areas. The Development of the Portrait Miniature in England 8 Illustrated devotional books were items of great expense in European courts and the Burgundian and Hapsburg dynasties were avid patrons of the art form. By the mid-1400s, Flanders had become the epicentre of production. 9 Single leaf illuminations were also available, to be pasted into volumes at a later date or hung as devotional texts and images on interior walls. Durer’s purchase of an image of Christ from Susanna Horenbout is an example of this format. Illuminators were also employed to illustrate important documents and this tradition was used in court papers produced in England as outlined in Auerbach’s research on the plea rolls. The earliest portraits appear in the plea rolls of the King’s Bench. The initial P of Placita (pleas) forms a circular format to frame a royal portrait. The earliest known example is the roll of Easter 1460 and depicts Henry VI. 10 Commissioned by judges or officials at court, the quality of the limning and artistic merit varies across these works, but it is an important stage in the development of the portrait miniature in England. The earliest known example of an independent miniature produced in England is the Portrait of Princess Mary attributed to Lucas Horenbout in the collection of the National Portrait Gallery, London. 11 12 also attributed to Lucas Horenbout, is an interesting early portrait miniature of royalty outside the immediate family of Henry VIII, copied from an existing portrait in the Royal Collection. 13 An important series of six miniatures depict Henry VIII and are attributed to Lucas Horenbout, dating between 1525 and 1530. They repeat the same format but show the king with differing facial hair and attire; it is assumed a pattern was used to create the versions. 14 A link between these portraits and those found on court documents can be found on the letters patent of Henry VIII for Thomas Forster in Latin 1524, 28 April. 15 16 17 Other examples of small books with images pasted in the front and back exist and suggest an additional usage for single leaf illuminations, especially considering other rectangular miniatures such as the Katherine of Aragon with a Marmoset in the Buccleuch Collection. Technical Examination of Portrait of an Unknown Lady DOI DOI The miniature is painted in watercolour on vellum, which has been mounted onto a piece of laid paper at an early stage in its history, although this is not part of the original construction. 18 Looking at the back of the work, the reversed image of the sitter is clearly visible through the paper. At the top, water staining is evident which is also visible on the front of the painting ( Fig. 3 Infra-red photography revealed some surprising elements in the creation of the miniature. 19 Drawing lines were detected which have been made using a carbon-based material and show evidence of a change in the dimensions of the sitter’s face at an early stage ( Fig. 4 DOI Figure 4.Lucas Horenbout, Portrait of an Unknown Lady (infra-red photograph), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59).Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Fig. 5 ). In 1573, the anonymous treatise The Arte of Limming was published by Richard Totill of London. The work proved surprisingly popular and six editions were printed between 1573 and 1605. 20 Unlike later treatises on limning, the work does not focus on portrait miniatures but is concerned with the decorative forms of limning based on the tradition of manuscript illumination and used for a variety of books and documents. The instructions for drawing are as follows: The order of drawing or tracing . First thou shalte with a pencell of blacke lead, or with a cole made sharpe at the poynte trace all thy letters, and sett thy vinetts of flowers, and then thy imagery if you wilt make any. And then shalt thou with a small pen drawe al you hast postred 21 Marking out the design for an illuminated manuscript involved drawing the outlines before colour was laid in, typically using inks applied with a brush or quill. A lovely example of this working method can be seen in Self Portrait of Simon Bening ( Fig. 6 ). 22 On the easel in front of the artist is a sketch on parchment of the Virgin and Child; a small shell contains blue pigment, the colour of the Virgin’s robes, suggesting Bening is just about to start applying colour to his initial drawing. The quote from the 1573 treatise suggests drawing with charcoal or by using a brush (then called a “pencil”) to apply black lead. 23 Starting a miniature with an outline in black differs from the later technique described by Hilliard and that which is observed on the majority of portrait miniatures. This could suggest a link between the technical methods of the maker of Portrait of an Unknown Lady with earlier practices of manuscript illumination. The pigments used in the YCBA miniature were examined using XRF spectroscopy—a method which detects elements within the paint layer and helps to determine the pigments used in its manufacture. 24 The pigments found in this portrait are typical of those routinely used in the manufacture of miniatures in the 1500s. The flesh contains two whites, lead white, and a chalk-based white, mixed with small quantities of vermilion and earth pigments ( Fig. 7 DOI Figure 7.Lucas Horenbout, Portrait of an Unknown Lady (results of XRF analysis), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59).Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Examination of a miniature through a microscope is one of the most helpful tools in understanding an artist’s particular style and their method of applying the paint. Previous discussions around the attribution of this miniature have commented negatively on the “thin and transparent” painting technique used in the features, which has been seen as an indication of poor-quality handling. 25 The artist has laid in a carnation layer of pale pink containing very fine pigment particles. An x-ray of the painting confirms the uses of the two white pigments, utilised to achieve different effects ( Fig. 8 ). Lead white was used for the whites of the eyes and as highlights around the features, which show as dense white areas in x-ray. A chalk-based white has been used in the carnation; x-rays penetrate through calcium carbonate, producing darker areas in the x-ray image. Around the eyes are distinctive, short, calligraphic strokes, rendered on a miniature scale ( Figs 9 and 10 Fig. 11 ). Figure 8. Lucas Horenbout, Portrait of an Unknown Lady (X-radiograph), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Figure 9. Lucas Horenbout, Portrait of an Unknown Lady (photomicrograph detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Figure 10. Lucas Horenbout, Portrait of an Unknown Lady (detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). DOI Figure 11. Lucas Horenbout, Portrait of an Unknown Lady (photomicrograph detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). One of the most beautiful elements of the miniature is the depiction of the jewel with cowslips and acorns, set on the front of the sitter’s dress ( Fig. 12 Figs 13 and 14 ). Figure 12. Lucas Horenbout, Portrait of an Unknown Lady (detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Figure 13. Lucas Horenbout, Portrait of an Unknown Lady (detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Figure 14. Lucas Horenbout, Portrait of an Unknown Lady (detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). Attribution of the Miniature 26 Despite the lack of a body of work that can be attributed to her, in the literature on miniatures, Teerlinc’s abilities are often referred to in a negative way. Miniatures are attributed to her on the grounds that the handling is weak and that the arms are too thin. To quote from Strong’s entry for Teerlinc in the Oxford Dictionary of National Biography, “Their most characteristic feature is a head attached to a too small, spindly body. Their technique is awkward, thin and often cursory”. 27 Inscription The work of Roy Strong and Jim Murrell in the 1980s was instrumental in grouping together a series of miniatures that could be attributed to Lucas Horenbout. Their approach involved close examination of the miniatures through a microscope and comparison of the techniques employed across the group. 28 The inscriptions are distinct and suggest that these miniatures can be grouped together, although the lettering does vary in handling. Six of the miniatures share a distinctive A, which has a heavy serif topping the letter. Katherine of Aragon 29 shows two types of A, all with the heavy serif and one with two downward sloping diagonal lines forming the cross of the A, which is also seen on the Yale miniature ( Fig. 15 DOI Figure 15.Lucas Horenbout, Portrait of an Unknown Lady (detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59).Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). The Horenbout Family Gerard Horenbout lived and worked in Ghent and was accepted as a master of the painter’s guild in 1487. 30 valet de chambre to Margaret of Austria, regent of the Netherlands and appears regularly in her documented accounts from 1516–1522. 31 Karel van Mander gives a detailed description of two pictures by Gerard Horenbout in his 1604 book of artist’s biographies. 32 The works are undoubtedly larger paintings in oil and Campbell and Foister’s research into the documentary evidence on Gerard Horenbout show he is consistently described as a painter rather than an illuminator. However, in his diary, Durer specifically refers to him as “ maister Gerhart, illuminist ” . In Lodovico Guicciardini’s 1567 account of the history and arts of the Low Countries, written twenty years after Gerard Horenbout’s death, the artist is described as excellent in the art of illumination. 33 It seems that Gerard Horenbout, like many artists at this time, was actively engaged in a variety of work. 34 For example, as court painter, Holbein carried out numerous projects including painting large cloths to serve as decorative hangings for the meeting of Henry VIII and François I at Greenwich in 1527. 35 In France, François and Jean Clouet developed the portrait miniature format and were also painting portraits in oil. Recent research into Hilliard’s period in France has finally made a conclusive link to two works in oil, which confirms the long-held theory that he painted in this medium as well as limning. 36 That Gerard Horenbout was an artist skilled in the tradition of illuminated manuscripts is confirmed by the only firmly documented works attributed to him: sixteen full-page illuminations created for the Hours of Bona Sforza , commissioned while he was in the employ of Margaret of Austria. The volume is now in the collection of the British Library. 37 Hours of Bona Sforza paintings, an example of the Horenbout family members working together on a project. 38 There are no known records of Gerard Horenbout’s activities after 1522 and the next time he appears in documents is October 1528, working for Henry VIII. 39 Frustratingly, the accounts do not help to define the period Gerard Horenbout is employed at the English court as some records are lost and it is plausible that he had arrived in England at an earlier date. Nor do the records help determine what role Gerard Horenbout had as “painter” to Henry VIII and whether he was actively producing works of art himself or managing some form of workshop. Gerard Horenbout’s son Lucas is the only Horenbout to whom miniatures are attributed in national collections within the UK. Once again, as Foister has pointed out, the court documents record Lucas Horenbout’s profession as a painter rather than an illuminator or “lymner of books”. Guicciardini states that Lucas is “ grandissimo pittore & singulare nell’arte dell’alluminare ”; the wording used here would imply Lucas was both a painter and an illuminator. 40 Van Mander records that a “Meister Lucas” taught Holbein the art of illumination and it is now confidently accepted that this refers to Lucas Horenbout. 41 Canones Horoptri by Nikolaus Kratzer, produced in 1528 and presented to the king as a New Year’s gift, was written by the scribe Peter Meghen and the manuscript decorated with ornate capitals painted by Holbein. 42 It is tempting to assume that Lucas Horenbout’s training of Holbein was as part of the production of this manuscript. Even more problematic to pin down in terms of artistic output is Lucas Horenbout’s sister Susanna. Durer’s reference to her in 1521 and acquisition of an example of her work are undeniably high praise for her artistic talents. Like her father and brother, her name occurs in various accounts of artists of merit. Guicciardini declares she excelled in all painting—miniatures and illuminations. 43 In Vasari’s Lives of the Artists , Susanna Horenbout is mentioned as one of the Flemish female artists who made a name at the court of Henry VIII. 44 It has been suggested before that the Horenbouts may have formed a similar workshop to that which Gerard Horenbout was running in Ghent. It is possible that the different hands evident in the series of miniatures of Henry VIII may be Susanna working alongside Lucas Horenbout. The payments and gifts that Susanna is recorded as receiving at court relate to her services as a gentlewoman, and while no surviving document to date shows her active as a limner, it cannot be ruled out that she is producing these intimate portraits, possibly of the ladies at court, within the circles she was mixing in. The fact that she is recorded after her death as having had a successful and celebrated career as an artist at Henry’s court must mean she was active as an artist during her time in England. Comparison of Portrait of an Unknown Lady with Other Works Attributed to Horenbout Figs 16 , 17 , 18 , 19 , 20 , 21 , 22 , and 23 ). Figure 16. Lucas Horenbout, Portrait of Henry VIII, circa 1525, watercolour on vellum, 5.3 × 4.8 cm. Fitzwilliam Museum, Cambridge (PD.19-1949). Digital image courtesy of Fitzwilliam Museum, Cambridge (All rights reserved). Figure 17. Lucas Horenbout, Henry VIII, circa 1526–1527, watercolour on vellum, 4 × 5.2 cm. Royal Collection (RCIN 420010). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). Figure 18. Lucas Horenbout, Henry VIII (photomicrograph detail), circa 1526–1527, watercolour on vellum, 4.7 × 6.2 cm. Royal Collection (RCIN 420640). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). Figure 19. Lucas Horenbout, Henry Fitzroy, Duke of Richmond and Somerset, circa 1533–1534, watercolour on vellum, 4.4 × 5.9 cm. Royal Collection (RCIN 420019). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). Figure 20. Lucas Horenbout, Queen Mary I, circa 1525, watercolour on vellum, 3.5 cm diameter. National Portrait Gallery, London (NPG 6453). Digital image courtesy of National Portrait Gallery, London (All rights reserved). Figure 21. Lucas Horenbout, Katherine of Aragon, circa 1525, watercolour on vellum, 3.8 cm diameter. National Portrait Gallery, London (NPG 4682). Digital image courtesy of National Portrait Gallery, London (All rights reserved). Figure 22. Lucas Horenbout, Katherine of Aragon, circa 1525–1526, watercolour on vellum, 3.9 cm diameter. On long-term loan to the National Portrait Gallery, London (NPG L244). Digital image courtesy of National Portrait Gallery, London (All rights reserved). Figure 23. Lucas Horenbout, Henry VIII, circa 1526–1527, watercolour on vellum, 4.7 × 6.2 cm. Royal Collection (RCIN 420010). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). A common element in all of the miniatures is the modelling of the features in pink and grey strokes applied over a pink carnation layer. This method of handling was found to be consistent in all the works attributed to Horenbout which Murrell examined. 45 Fig. 23 ). Fig. 13 ) to the free, linear strokes seen on the bearded version of Henry in the Royal Collection ( Fig. 18 ). 46 The handling of the lips on the Yale miniature falls somewhere between these two methods ( Figs 24 , 25 , and 26 ). Figure 24. Lucas Horenbout, Henry VIII (photomicrograph detail), circa 1526–1527, watercolour on vellum, 4.7 × 6.2 cm. Royal Collection (RCIN 420010). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). Figure 25. Lucas Horenbout, Henry VIII (photomicrograph detail), circa 1526–1527, watercolour on vellum, 4.7 × 6.2 cm. Royal Collection (RCIN 420640). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). Figure 26. Lucas Horenbout, Henry Fitzroy, Duke of Richmond and Somerset (photomicrograph detail), circa 1533–1534, watercolour on vellum, 4.4 × 5.9 cm. Royal Collection (RCIN 420019). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). DOIThe handling of the highlight in the eye is another feature uniting this group of portraits and appears to be unique to these miniatures (Figs 27and28). Rather than a dot, or series of dots, the light is rendered as a horizontal line created by applying a single brushstroke of thick-bodied lead white paint on top of the iris and stopping at the outline of the pupil. Also worth noting is the use of blue pigment particles mixed into the white of the eye in the bearded version of Henry VIII in the Royal Collection. This is a device typically seen in oil paintings of this period, but is not commonly found in miniatures. Figure 27. Lucas Horenbout, Katherine of Aragon (photomicrograph detail), circa 1525–1526, watercolour on vellum, 3.9 cm diameter. on long-term loan to the National Portrait Gallery, London (NPG L244). Digital image courtesy of National Portrait Gallery, London (All rights reserved). DOI Figure 28. Lucas Horenbout, Henry VIII (photomicrograph detail), circa 1526–1527, watercolour on vellum, 4.7 × 6.2 cm. Royal Collection (RCIN 420640). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). Fig. 29 ). These indicate that the lines were applied from bottom to top while both Royal Collection versions appear to be painted top to bottom. In the bearded version of Henry VIII, the lines have been applied twice. The fine blackwork pattern was then applied as the final detail. When viewing the photomicrographs and determining themes that connect these works, there is a sense that although they are striving for the same aesthetic, the handling differs across the group. This may suggest that we have different artists at work and again the possibility that we are seeing the hands of Gerard, Lucas, and Susanna Horenbout employed in making versions of this portrait, following a workshop pattern. Identity of the Unknown Lady 47 48 The dress is very similar in both portraits as is the close cropping so that only part of the huge cuffs is visible, with the space between the arms and chest emphasised and the arms held slightly away from the body. The early portrait miniature was the prerogative of the inner royal circle, when the Horenbouts were active at court. Combined with the evidence of the dress in the Yale miniature, we can be certain that the lady depicted is of royal status. In recent years, the sitter in the Yale miniature has been identified as Lady Jane Grey. 49 Figure 30. Lucas Horenbout, Portrait of an Unknown Lady (photomicrograph detail), circa 1533–1534, watercolour on vellum, 7 × 6.4 cm. Yale Center for British Art, Paul Mellon Collection (B1974.2.59). Digital image courtesy of Yale Center for British Art, Paul Mellon Collection (Public Domain). DOI Figure 31. Hans Holbein the Younger, Princess Mary, later Queen, circa 1536, black and coloured chalks, and pen and ink on pale pink prepared paper, 38.6 × 29.1 cm. Royal Collection (RCIN 912220). Digital image courtesy of Royal Collection Trust and Her Majesty Queen Elizabeth II 2020 (All rights reserved). Figure 32. Master John, Queen Mary I, 1544, oil on panel, 71.1 × 50.8 cm. National Portrait Gallery, London (NPG 428). Digital image courtesy of National Portrait Gallery, London (All rights reserved). Given that the sitter’s age is stated on the miniature as being eighteen, this would date the work to 1533–1534, if it depicts Princess Mary. This was a difficult period for Mary. Her parents had recently divorced and her father had married Anne Boleyn. Mary’s mother, Katherine of Aragon, was banished from court and as part of the campaign to make her renounce her royal claim, mother and daughter were banned from seeing each other. Owing to a cruel act of control by Henry, which forbade Mary from attending her mother’s sick bed, Katherine died in 1536, having not seen her only child for several years. The First Act of Succession was passed in 1534, declaring Mary illegitimate. Although Henry VIII was free to name his successor, the document stated that issue of Anne Boleyn would be given precedence. Interestingly, the portrait miniature of Henry Fitzroy, Henry’s acknowledged but illegitimate son, was also painted around this date. Despite this turmoil, Henry VIII remained fond of his daughter and she was well provided for by the king with a generous clothing allowance at this time. For the reasons stated above, Mary was not present at court and was resident at various country houses during this problematic period. There is no record of Henry visiting her while Anne Boleyn held the title of queen. Would there have been a desire for a portrait of Mary to show the princess now as a young woman, either for her banished mother or for her father, neither of whom had seen her for several years? If such a portrait had been commissioned at this time, it seems plausible that a female artist would have been a more suitable candidate to travel to the princess’s household. As Teerlinc would later be sent to Princess Elizabeth to draw her portrait, is it feasible that Susanna Horenbout was given the task to capture Mary’s likeness? Conclusion In conclusion, detailed examination and technical analysis undertaken on the Yale miniature Portrait of an Unknown Lady Acknowledgements I would like to thank Edward Town, for his collaboration on this project and for his unwavering support and help with the research. The technical examinations of other miniatures was possible due to the generosity of collections making works accessible: Henrietta Ward at the Fitzwilliam Museum, and Vanessa Remington and colleagues at the Royal Collection including Karen Lawson in the Picture Library. At YCBA, my thanks to Jessica David, Theresa Fairbanks-Harris, and Charlotte Padden. I am also grateful to colleagues at the NPG including Charlotte Bolland, Richard Hallas, and Catharine McLeod. Polly Saltmarsh is an easel paintings conservator based in Cambridge. She divides her time between running her studio and working at the National Portrait Gallery, London. With an MA(Hons) in Art History from the University of Glasgow, Polly completed a Postgraduate Diploma in Easel Painting Conservation at the Courtauld Institute, graduating in 2007. In 2008, Polly joined the Making Art in Tudor Britain team at the National Portrait Gallery, researching the materials and techniques of the Tudor and Jacobean paintings in the collection. In 2015, she was invited as a visiting scholar to the Yale Center for British Art to undertake technical research on the collection of early miniatures. She has previously co-published papers focusing on workshop production, in particular patterns and replication. Footnotes Susan Foister, “Horenbout (Hornebolt), Lucas ( d. 1544)”, Oxford Dictionary of National Biography(Oxford: Oxford University Press, 2004), doi:10.1093/ref:odnb/13798. 1 Lorne Campbell and Susan Foister, “Gerard, Lucas and Susanna Horenbout”, The Burlington Magazine128, no. 1003 (1986), 720. 2 Lodovico Guicciardini states this in his Descrittone di tutti i Paesi( Description of the Low Countries), see Foister, “Horenbout (Hornebolt), Susanna (d in or before 1554)”, Oxford Dictionary of National Biography, Oxford University Press, 2004. 3 It is now firmly believed that Simon Bening and Gerard Horenbout worked together on the Grimani Breveiary (Biblioteca Marciana, Venice), for example, see Joris C. Heyder, “Kopie und Kennerschaft über eine künstlerische Praxis und ihre Bedeutung für die Erforschung der flämischen Buchmalerei”, Kunstgeschichte:Open Peer Reviewed Journal (2013),https://pub.uni-bielefeld.de/record/2907481. 4 Roy Strong, The English Renaissance Miniature(London: Thames and Hudson, 1983), 55. 5 Erna Auerbach, Tudor Artists: A Study of Painters in the Royal Service and of Portraiture on Illuminated Documents from the Accession of Henry VIII to the Death of Elizabeth I(London: The Athlone Press, 1954), 75–76. 6 Roy Strong, Artists of the Tudor Court: The Portrait Miniature Rediscovered, 1520–1620(London: Victoria and Albert Museum, 1983), 52–53; and Strong, The English Renaissance Miniature, 58. 7 Janet Backhouse, “Illuminated Manuscripts and the Early Development of the Portrait Miniature”, in Daniel Williams (ed.), Early Tudor England: Proceedings of the 1987 Harlaxton Symposium(Woodbridge: Boydell, 1989), 2–3. 8 Thomas Kren and Scot McKendrick (eds), Illuminating the Renaissance: The Triumph of Flemish Manuscript Painting in Europe(Los Angeles, CA: J. Paul Getty Trust, 2003), 3. 9 Auerbach, Tudor Artists, 1. 10 NPG 6453. 11 V&A P.22-1942. 12 RCIN 403439. 13 Patterns were an important tool in an artist’s workshop, used to create multiple versions of a portrait or pose. The patterns were either a reference sketch or tracing from a finished work, which were kept in the studio for future use, see Sophie Plender and Polly Saltmarsh, “Copies and Versions: Discussing Holbein’s Legacy in England: Technical Examination of Copies of Holbein Portraits at the National Portrait Gallery”, in Erma Hermens (ed.), European Paintings 15th–18th Century: Copying Emulating and Replicating(London: Archetype, 2014); and Sophie Plender and Polly Saltmarsh, “Calling Authenticity into Question: Investigating the Production of Versions and Copies in Tudor Portraiture”, in Rebecca Gordon, Erma Hermens, and Frances Lennard (eds), Authenticity and Replication: The “Real Thing” in Art and Conservation(London: Archetype, 2014). Exactly how a pattern would be utilised by an artist creating miniatures is currently unclear. 14 MSL/1999.6, on long-term loan to the V&A. 15 PD.19-1949. 16 Backhouse, “Illuminated Manuscripts and the Early Development of the Portrait Miniature”, 16. 17 Watercolour was not a term used in the sixteenth century but is used today in relation to pigments bound in a water-based medium such as gum arabic or egg white. Bodycolour and gouache are also used to describe this medium, although this implies an opaque paint layer rather than a mixture of translucent and opaque applications. 18 A retrofitted Nikon 810 camera with Coastal Optical 60mm, macro 1:4, apochromatic lens which captures in the near IR range. 19 Katherine Coombs, “A Kind of Gentle Painting: Limning in 16th-Century England”, in Kim Sloan (ed.), European Visions: American Voices(London: British Museum, 2009), 80. 20 Anon., A Very Proper Treatise, wherein is briefly sett forthe the arte of Limming(London: Richard Totill, 1573), 1. 21 P159-1910 Victoria and Albert Museum. 22 It is unclear exactly what material the author of The Arte of Limmingis referring to when he mentions black lead, especially applied with a brush as instructed. It was a term for graphite but this was not commonly used as a drawing material until after 1580, although traces of graphite can be found in chalks, see Rachel Billinge, “The Materials of Underdrawing”, in David Bomford (ed.), Art in the Making: Underdrawing in Renaissance Paintings(London: National Gallery, 2002), 34; and Jim Murrell, “Graphic Descriptions: Side-Lights from Manuscript Sources on English Drawing Materials”, V&A Conservation Journal3 (April 1992), 14. 23 A Bruker Artax 800 x-ray fluorescence spectrometer was used to perform non-destructive elemental analysis. The spectrometer was equipped with a rhodium anode x-ray tube fitted with polycapillary optics that result in a beam diameter of approximately 75–100 μm at the sample surface. Spectra were acquired for 120 seconds live time using 45 kV accelerating potential, 400 μA current, and without any excitation beam filters. Helium was used to displace air from the x-ray beam path between the source and the sample and between the detector and the sample during analysis. The analysis was carried out by Jens Stenger, conservation scientist at Yale University’s Institute for the Preservation of Cultural Heritage. 24 Strong, Artist’s of the Tudor Court, 52. 25 For recent discussion on the oeuvre of Teerlinc, see Katherine Coombs and Alan Derbyshire, “Nicholas Hilliard’s Workshop Practice Reconsidered”, in Tarnya Cooper, Aviva Burnstock, Maurice Howard, and Edward Town (eds), Painting in Britain 1500–1630: Production, Influences and Patronage(London: The British Academy, 2015), 242–243. 26 Roy Strong, “Teerlinc, Levina (d. 1576)”, Oxford Dictionary of National Biography(Oxford: Oxford University Press, 2004). 27 Strong discusses the Horenbout miniatures in both Artists at the Tudor Courtand lists the known works in The English Renaissance Miniature, 189. Murrell discusses the materials and techniques observed on this group of miniatures in The Way Howe to Lymne: Tudor Miniatures Observed(London: Victoria and Albert Museum, 1983) . 28 NPG 4682. 29 For a full discussion on the known documentary evidence of Gerard Horenbout’s work in Ghent, see the following publications: Susan Foister, “Horenbout (Hornebolt), Gerard ( d. 1540/1)”, Oxford Dictionary of National Biography(Oxford: Oxford University Press, 2004); and Campbell and Foister, “Gerard, Lucas and Susanna Horenbout”, 720. 30 Foister, “Horenbout (Hornebolt), Gerard ( d. 1540/1)”. 31 Carel van Mander, Dutch and Flemish Painters, translation from Schilderboeck(1604) and Introduction by Constant van der Wall (New York: McFarlane, Warde, and McFarlane, 1936). 32 Lodovico Guicciardini, Descrittione di Lodovico Guicciardini patritio fiorentino di tutti i Paesi Bassi altrimenti detti Germania inferiore(Antwerp: Guglielmo Silvio, 1567). 33 Claims have been made for a painted output by Lucas and Gerard Horenbout, including Strong’s suggestion that Lucas is the Cast Shadow Master; see Strong, The English Renaissance Miniature, 42–44. Gerard Horenbout is increasingly believed to be the artist Master of James IV, who is credited with producing works in both oil and illuminations. Most tantalising of all is the assertion by Georges Hulin de Loo that the Poortakker Triptych in Ghent, is by Gerard Horenbout; the work is apparently signed “Gerarde”. See Kren and McKendrick, Illuminating the Renaissance, 375–431; for a discussion of the output of Simon Bening and Gerard David and workshop production, see also Maryan W. Ainsworth, “‘Diverse Patterns Pertaining to the Crafts of Painters or Illuminators’: Gerard David and the Bening Workshop”, Master Drawings41, no. 3, Early Netherlandish Drawings(April 2003): 240–265. 34 Susan Foister and Tim Batchelor, Holbein in England, exhibition catalogue, Tate Britain, 26 September 2006–7 January 2007 (London: Tate Publishing, 2006), 164. 35 Sarah Bayliss, Juliet Carey, and Edward Town, “Nicholas Hilliard’s Portraits of Elizabeth I and Sir Amias Paulet”, The Burlington Magazine160, no. 1386 (2018): 716–726. 36 MS Add. 34294. See Mark L. Evans, The Sforza Hours(London: The British Library, 1992), 28. 37 Kren and McKendrick, Illuminating the Renaissance, 431. 38 Campbell and Foister, “Gerard, Lucas and Susanna Horenbout”, 720. 39 Guicciardini, Descrittione di Lodovico Guicciardini patritio fiorentino di tutti i Paesi Bassi altrimenti detti Germania inferiore. 40 Van Mander, Dutch and Flemish Painters. 41 MS. Bodl. 504. See Foister and Batchelor, Holbein in England, 164. 42 Guicciardini, Descrittione di Lodovico Guicciardini patritio fiorentino di tutti i Paesi Bassi altrimenti detti Germania inferiore. 43 Giorgio Vasari, Lives of the Most Eminent Painters, Sculptors and Architects, translated by Gaston du. C. de Vere (London: Philip Lee Warner, 1912–1915). 44 Murrell, The Way How to Lymne, 9. 45 It is interesting to note that pronounced, full red lips are also a distinct feature of the pages attributed to Gerard Horenbout in the Sforza Hours. 46 My thanks to Aileen Ribeiro for her thoughts on the sitter’s dress and dating. 47 RCIN 912252. 48 David Starkey and Bendor Grosvenor, Lost Faces: Identity and Discovery in Tudor Royal Portraiture(London: Philip Mould, 2007), 79–84. 49 Bibliography Ainsworth, Maryan W. (2003) “‘Diverse Patterns Pertaining to the Crafts of Painters or Illuminators’: Gerard David and the Bening Workshop”. Master Drawings41, no. 3, Early Netherlandish Drawings(April): 240–265. 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(2013) “Kopie und Kennerschaft über eine künstlerische Praxis und ihre Bedeutung für die Erforschung der flämischen Buchmalerei” . Kunstgeschichte.Open Peer Reviewed Journal.https://pub.uni-bielefeld.de/record/2907481. Kren, Thomas and McKendrick, Scot (eds) (2003) Illuminating the Renaissance: The Triumph of Flemish Manuscript Painting in Europe.Los Angeles, CA: J. Paul Getty Trust. MacLeod, Catharine et al. (eds) (2019) Elizabethan Treasures: Miniatures by Hilliard and Oliver. London: National Portrait Gallery. Mander, Carel van (1936) Dutch and Flemish Painters, translation from Schilderboeck(1604) and Introduction by Constant van der Wall. New York: McFarlane, Warde, and McFarlane. Murrell, Jim (1983) The Way How to Lymne: Tudor Miniatures Observed. London: Victoria and Albert Museum. Murrell, Jim (1992) “Graphic Descriptions: Side-Lights from Manuscript Sources on English Drawing Materials”. 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Imprint Author Polly Saltmarsh Date 30 September 2020 Category Article Review status Peer Reviewed (Double Blind) Licence CC BY-NC International 4.0 Downloads PDF format Article DOI https://doi.org/10.17658/issn.2058-5462/issue-17/psaltmarsh Cite as Polly Saltmarsh, " Portrait of an Unknown Lady : Technical Analysis of an Early Tudor Miniature", British Art Studies, Issue 17, https://doi.org/10.17658/issn.2058-5462/issue-17/psaltmarsh Next A Very Proper Treatise: Specialist Knowledge for a Non-Specialist Public
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[ GR No. L-14887, Jan 31, 1961 ] AVELINO NATIVIDAD v. CA + DECISION 110 Phil. 992 [ G.R. No. L-14887, January 31, 1961 ] AVELINO NATIVIDAD, PETITIONER, VS. COURT OF APPEALS, ET AL., RESPONDENTS. D E C I S I O N BENGZON, J.: Avelino Natividad and Fermin Villanueva were charged with theft of electric current, in the Manila court of first instance. They were convicted. On appeal, the Court of Appeals affirmed the conviction of the first, but acquitted Villanueva. Hence this petition for review, which is mainly based on the proposition that as both accused had been prosecuted for having conspired to steal electric current, the exoneration of one should entail the acquittal of the other. "The electric current consumption registered by exhibit A from August 9 to August 20, 1951 when it was removed, was 6980; and that as shown by the substitute meter, from the latter date up to September 8, was 1660, or a total of 8,640 KWH the value of which P478.00 * * *." "When he was investigated by the Manila Police, Natividad denied having tampered with the electric meter in question; but on November 9, 1951, he appeared before Attorney C. S. Van Hoven of complainant's legal department, who took Natividad's affidavit which was signed and sworn to before Attorney Pastor S. del Rosario of the same department on February 26, 1952 (Exh. G) * * * wherein he admitted that for the consideration of P150.00 which his co-appellant Villanueva promised to pay him and his companions, he (Natividad) agreed to tamper with exhibit A in order to reduce Villanueva's electric bill, and that on July 10, 1951, instead of actually reading the meter he merely recorded 130 as the reading, which is very much lower than the previous reading of 202 * * *." "The evidence is clear and convincing that he has not recorded the true and correct reading of Villanueva's meter but instead made a false reading to reduce the amount to be paid by Villanueva to Meralco for his current, and in addition he (Natividad) also personally tampered with the meter." It will be observed that the gist of the crime was that in accordance with a previous understanding with consumer Villanueva, this appellant Natividad [1] meter-reader of the Meralco misread the electric meter so as to decrease the amount which such consumer had to pay, and paid, to the owner of the electric current, the Meralco. According to the appellate court, Natividad knowingly "under-read" the electric meter in Villanueva's premises and falsely reported the readings during the period from June 9 to July 10, 1951, and from July 10 to August 9, 1951, thereby enabling Villanueva to appropriate, for nothing, about 11,830 electric kilowatt hours valued at P594.00. Meralco was thus pro tanto deprived of its property through the connivance of this employee. As to such connivance and deprivation there can be no doubt, because the petitioner himself so confessed in an affidavit. The resulting situation does not materially differ from the case of U. S. vs . Carlos, 21 Phil. 553, wherein the consumer of electric current having managed to evade payment of part of his accounts by using the so-called "jumper" to deflect the current from the house electric meter, was held by this Court to be guilty of theft. Contrary to petitioner's contention, the acquittal of Villanueva did not necessarily mean that no electric current had been taken away gratis. There was a factual finding of such larceny by the Court of Appeals, which we are not at liberty to disturb. Anyway, the acquittal rested on the lack of proof that Villanueva had tampered with the electric meter to conceal the crime. The offense was already committed when Villanueva paid his bills (reduced) for July and August. [2] And herein petitioner admitted such bills and payment accorded with his "under-reading." If it be argued that, without such tampering, the theft could not have been "consummated" because sooner or later, the true consumption will be discovered and the consumer will be made to pay accordingly, the answer is, there are other ways of concealing the swindle or of evading payment of the unreported fluid consumption. We must, therefore, affirm the conviction; and as there is no question raised concerning the penalty, [3] the judgment of the appellate court is hereby affirmed, with costs. Paras, C. J., Padilla, Bautista Angelo, Labrador, Concepcion, Reyes, J. B. L., Barrera , and Paredes, JJ ., concur. [1] He was paid money for it. [2] Cf. U.S. vs . Tambunting, 41 Phil. 364. [3] 6 years and 1 day to 9 years and 4 months of prision mayor, plus indemnity of P594.00 tags
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limma powers differential expression analyses for RNA-sequencing and microarray studies Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015 Apr 20;43(7):e47. doi: 10.1093/nar/gkv007. Epub 2015 Jan 20. limma powers differential expression analyses for RNA-sequencing and microarray studies Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth, Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth Abstract limma is an R/Bioconductor software package that provides an integrated solution for analysing data from gene expression experiments. It contains rich features for handling complex experimental designs and for information borrowing to overcome the problem of small sample sizes. Over the past decade, limma has been a popular choice for gene discovery through differential expression analyses of microarray and high-throughput PCR data. The package contains particularly strong facilities for reading, normalizing and exploring such data. Recently, the capabilities of limma have been significantly expanded in two important directions. First, the package can now perform both differential expression and differential splicing analyses of RNA sequencing (RNA-seq) data. All the downstream analysis tools previously restricted to microarray data are now available for RNA-seq as well. These capabilities allow users to analyse both RNA-seq and microarray data with very similar pipelines. Second, the package is now able to go past the traditional gene-wise expression analyses in a variety of ways, analysing expression profiles in terms of co-regulated sets of genes or in terms of higher-order expression signatures. This provides enhanced possibilities for biological interpretation of gene expression differences. This article reviews the philosophy and design of the limma package, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. Figures <here is a image b24fd08e649aae79-80b1cb941d3e2ee3> Figure 1. Schematic of the major components that are central to any limmaanalysis. For each gene g, we have a vector of gene expression values ( y g) and a design matrix Xthat relates these values to some coefficients of interest (β g). The limmapackage includes statistical methods that (i) facilitate information borrowing using empirical Bayes methods to obtain posterior variance estimators (), (ii) incorporate observation weights ( w gjwhere jrefers to sample) to allow for variations in data quality, (iii) allow variance modelling to accommodate technical or biological heterogeneity that may be present and (iv) pre-processing methods such as variance stabilization to reduce noise. These methods all help improve inference at both the gene and gene set level in small experiments. <here is a image 53cdcd17a911404f-d67de8f625aa4a94> Figure 2. The limmaworkflow. The diagram shows the main steps in a gene expression analysis, along with individual functions that might be used and the corresponding classes used to store data or results. Online documentation pages are available both for each individual function and for each major step. <here is a image 6a3ecc07fb935c8e-d7d7da8ee75cd0be> Figure 3. Example diagnostic plots produced by limma. ( A) Plot of variability versus count size for RNA-seq data, generated by voom with plot=TRUE. This plot shows that technical variability decreases with count size. Total variability asymptotes to biological variability as count sizes increases. ( B) Mean-difference plot produced by the plotMA function for a two-colour microarray. The plot highlights negative (NC), constant (DR) and differentially expressed (D03, D10, U03, U10) spike-in controls. Regular probes are non-highlighted. ( C) Multidimensional scaling (MDS) plot of a set of 30 microarrays, generated by plotMDS. All arrays are biologically identical and the plot reveals strong batch effects. Distances represent leading log2-fold changes between samples. <here is a image 1e857d635c62f705-6d1d3b0ec8fb1b06> Figure 4. Example plots displaying results from DE and gene set analyses. ( A) Volcano plot showing fold changes and posterior odds of DE for a particular comparison (RUNX1 over-expression versus wild-type in this case), generated by volcanoplot. Probes with P< 0.00001 are highlighted in red. ( B) Venn diagram showing overlap in the number of DE genes for three comparisons from the same study as (A), generated by the vennDiagram function. ( C) Gene set enrichment plot produced by barcodeplot. The central bar orders differentially expressed genes by significance from up to down upon Pax5 restoration in an RNA-seq experiment (7). The vertical bars mark genes that are induced (red) or repressed (blue) upon the transition from large cycling pre-B cells to small resting pre-B cells during normal B cell development according to the published literature (47). The plot shows a strong positive concordance between Pax5 restoration and the large to small cell transition. The roast function can be used to assign statistical significance to this correlation. 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https://ichgcp.net/clinical-trials-registry/publications/94732-limma-powers-differential-expression-analyses-for-rna-sequencing-and-microarray-studies
Gittings v. Jeffords, 22348. - Missouri - Case Law - VLEX 893675837 0: [object Object]. 1: [object Object]. 2: [object Object]. 3: [object Object]. 4: [object Object]. 5: [object Object] Missouri Gittings v. Jeffords, 22348. Court United States State Supreme Court of Missouri Writing for the Court Elder Citation 292 Mo. 678,239 S.W. 84 Parties GITTINGS v. JEFFORDS et al. Docket Number No. 22348.,22348. Decision Date 14 March 1922 239 S.W. 84 292 Mo. 678 GITTINGS v. JEFFORDS et al. No. 22348. Supreme Court of Missouri, Division No. 1. March 14, 1922. [239 S.W. 85] Appeal from Circuit Court, Clay County; Ralph Hughes, Judge. Action to contest will by Paul Thomas Gittings against Tracy L. Jeffords and others. From judgment establishing the will, plaintiff appeals.Affirmed. Harris L. Moore, of Excelsior Springs, for appellant. Craven & Bates, of Excelsior Springs, and Claude Coppinger, of Liberty, for respondents. ELDER, J. This as action to contest the validity of the will of Mary O. Dallas, who died in Washington, D. C., on May 5, 1918. Plaintiff is the half-brother of deceased. Defendant Tracy L. Jeffords is executor of the will of deceased and principal beneficiary thereunder. The remaining defendants are a half-brother, a half-sister, three nieces, a nephew and a cousin of the deceased. The grounds of contest were mental incapacity, fraud and undue influence. Upon the trial the issue of mental incapacity was abandoned. The verdict of the jury established the instrument in controversy as the last will of the deceased. From a judgment so holding plaintiff has appealed. Mary O. Dallas, the testatrix, was a widow who had been twice married. She at one time resided at Excelsior Springs, Missouri, but for several years before her death had lived in the City of Washington, D. C. Defendant Jeffords is a practicing attorney of Washington. According to his testimony he became acquainted with Mrs. Dallas in 1911 or 1912 through meeting her at a boarding house where they both roomed. In December, 1913, Mrs. Dallas rented an apartment and Mr. Jeffords then began taking his evening meal with her, for which he paid her a dollar a day. Later one of Mrs. Dallas' nieces came to room and board with her and defendant Jeffords aided the niece in securing a position. His relations with Mrs. Dallas were always friendly and occasionally he would spend the evening at her home. During the lifetime of her, second husband she had lived in an aristocratic neighborhood and had had plenty of money. After his death she became somewhat financially embarrassed having an income of but about $136.00 a year. She, however, owned some real estate in Excelsior Springs, worth from $6,000 to $7,000, which she was continually endeavoring to sell. Being in need of ready money she applied to defendant Jeffords who from time to time loaned her various sums which by January, 1915, amounted to $1,000 in the aggregate. About that time a settlement was effected and Mrs. Dallas gave Mr. Jeffords a deed to one of the lots in Excelsior Springs, the same being valued at $2,000, but encumbered by a mortgage for $1,000. Mrs. Dallas, however, continued to pay the taxes on the property and the interest on the mortgage. Mr. Jeffords testified that it was immaterial to him whether the conveyance was considered an outright deed or a mortgage.He said: "If I get my thousand dollars back and interest, I am willing to give back the property to anybody who pays the thousand dollars and interest, and to whom I ought to give it up. All I want is my money and the interest." About the time of the above-mentioned settlement Mrs. Dallas came to defendant Jeffords' office and handed him a written memorandum, in her own handwriting, of a will she requested him to put in legal form. Pursuant to such request Mr. Jeffords drew a will, conforming to the memorandum, dated January 25, 1915, under which he was bequeathed the sum of $1,000 and made a residuary trustee as to all property not otherwise disposed of. He testified that he had had no previous conversation with Mrs. Dallas as to the terms of the said will and that he did not directly or indirectly offer any suggestions with respect thereto. This will was introduced in evidence but we do not deem it necessary to reproduce it. After the delivery to dependant of the deed to the lot in Excelsior Springs, given in settlement of the $1,000 then owing by Mrs. Dallas, defendant Jeffords continued to advance her a certain sum of money each month, payments being made by checks, which were introduced in evidence. The several amounts so advanced aggregated the 239 S.W. 86 sum of $2,131.83. With respect to such advancements Mr. Jeffords testified: "After that date and after that settlement I continued to advance money to her from month to month. She had a calculation of about how much she would need and asked me to advance it each month." Part of the moneys so advanced was used in the payment of taxes, street improvements, and interest on mortgages affecting the Excelsior Springs property. The checks submitted in evidence usually ranged from $31 to $33 in odd amounts, such as $31.20, $32.62, $33.33, etc. Mr. Jeffords' explanation of this variation was that Mrs. Dallas did not wish a Mr. Hood, who was secretary and treasurer of the trust company where she did her banking business, and who was a cousin of her husband, to know that she was receiving the exact amount of her necessary expenses as he would have known if she had for instance deposited a check for $33.00 one day and drew a check for exactly the same amount the next day. One of the checks offered in evidence bearing date of November 6, 1915, was for $502.02, and, according to the testimony of defendant Jeffords, was given for the payment of special taxes against the Excelsior Springs property. Counsel for plaintiff endeavored to show that it was given as a consideration for the deed to the lot which Mrs. Dallas had executed in favor of Jeffords, but this the latter denied. Defendant Jeffords testified that In February, 1918, Mrs. Dallas came to his office and handed him a memorandum in her own handwriting for another will (being the will in suit), which she requested that he put in proper form. This memorandum was as follows: "To my cousin Irene Anna Babb MacDonald all my household effects. "To the eldest daughter of my half-brother, Paul Thomas Gittings, all my jewelry. "To my dear friend and attorney Tracy L. Jeffords all my money in bank and all my real estate to pay him back the money he has loaned me in the past and what he may loan me in the future with 10 per cent.interest. If there be any money left after he is paid in full to be divided between my cousin I. A. B. MacDonald and my nieces who may be alive at that time. My Liberty Bonds are to pay my funeral expenses. "16 Feby 1918. Mary O. Dallas." "Q. Now, did you make any suggestions there? Were there any suggestions made there relative to that rough draft? A. I made one suggestion. Her rough draft contains the language ten per cent. interest, and I suggested that she change it to legal interest and she said she wished that change made, and it was made. "Q. Now, with that draft, what did you do? A. I prepared or dictated, or had prepared, or caused to be prepared, the will which is in evidence here, a copy of which is in evidence here and which has been probated in Washington." The final draft of the will in suit, as submitted in evidence, omitting the attesting clause of witnesses, is as follows: "I, Mary O. Dallas, of Washington, D. C., do now make this my last will as follows: "I hereby revoke all wills by me heretofore made. "I give all my household effects to my cousin Irene Anna Babb MacDonald, and all my jewelry to the eldest daughter of my half-brother Paul Thomas Gittings. "It is my wish that my Liberty Bonds be used to pay my funeral expenses. "All the rest, residue, and remainder of all my money, property and estate including all hereafter acquired, I give, devise, and bequeath in fee simple, absolutely and forever to my friend and attorney Tracy L. Jeffords to pay him back money he has loaned and advanced to me in the past and may loan me hereafter, together with legal interest on same, and to that end I hereby direct that all my property and estate be sold and turned into money as soon after my death as my executor shall in his discretion determine, and he is hereby directed and empowered to make such sale and to convey said real estate by good and sufficient deed to any purchaser. "And after paying back all said money so loaned to me and all interest on it, if there be any left, I give it to my cousin Irene Anna Babb MacDonald and all my nieces then living to be divided among them equally, share and share alike. "I make, constitute and appoint Tracy L. Jeffords executor of this will and my estate. "In testimony whereof I have hereunto signed my name and affixed my seal at Washington, D. C., February 18, 1918. "Mary O. Dallas." Further testifying defendant Jeffords stated: "Q. Now, you say she brought in a memorandum for you to draw the will by?A. Yes, sir. "Q. As introduced in evidence. What, if anything, had you said to her about that memorandum prior to the drawing of the will? A. I had never said anything to her about any particular memorandum. She had talked about a will. "Q. What, if anything, did you say to her about how she should draw the will?A. Not a word. "Q. Did you discuss with her how she should distribute her property?A. I did not. "Q. Do you think that when she drew the will in 1918, February 18th, from your acquaintance with her, whether Mrs. Dallas comprehended and was of sufficient mind to comprehend who her relatives were at that time?A. She had sufficient mind. She had as much mind as she ever had when I knew her. "Q. Well, at that time. February 18th, from your acquaintance with her and from what you knew of her, would you say her mind was sound or unsound?A. It was sound as anybody's mind.* * * "Q. Do you remember what personal property she had at the time of her death?A. She had a little furniture, enough to furnish a small apartment, and she had $200 in Liberty Bonds, and one hundred eighty some dollars in the 239 S.W. 87 bank, and some jewelry and a few dollars in the house, I presume. "Q. About $10? A. About $10. A record has been made and the...
https://case-law.vlex.com/vid/gittings-v-jeffords-no-893675837
MGnify API: archiving, analysis and integration of metagenomics data. EMBL-EBI MGnify is a freely available hub for the analysis and exploration of metagenomic, metatranscriptomic, amplicon and assembly data. Submit, analyse, discover and compare microbiome data Access all the data within MGnify using our JSON:API specification API. Browse the API endpoints interactively here, or using your own scripts. We also have online examples in Python and R, in our MGnify Juptyer Lab. Browse examples MGnify website API Browser API Documentation About Help Log in Api Browser Sample List Sample Instance Sample Studies Relationship List GET json csv api OPTIONS Filters JSON:API includes Sample Studies Relationship List GET / metagenomics / api / v1 / samples / DRS024683 / studies ? ordering =- last_update HTTP 200 OK Allow: GET, HEAD, OPTIONS Content-Type: application/json Vary: Accept { "links" : { "first" : " https://www.ebi.ac.uk/metagenomics/api/v1/samples/DRS024683/studies?ordering=-last_update&page=1 " , "last" : " https://www.ebi.ac.uk/metagenomics/api/v1/samples/DRS024683/studies?ordering=-last_update&page=1 " , "next" : null , "prev" : null }, "data" : [ { "type" : "studies" , "id" : "MGYS00002355" , "attributes" : { "samples-count" : 2344 , "accession" : "MGYS00002355" , "bioproject" : "PRJDB4107" , "is-private" : false , "secondary-accession" : "DRP003041" , "centre-name" : "KYUSHU" , "public-release-date" : null , "study-abstract" : "We collected saliva from Japanese adults aged over 40 years inhabiting Hisayama town, Fukuoka, Japan in a health examination performed as a part of the follow-up survey of the Hisayama cohort study on 2007. The V1-V2 region of 16S amplicon sequence of human salivary microbiome were analyzed using Ion PGM. The project goal is to identify core and pan salivary microbiome in Japanese adults and to clarify the relationship with host''s health and health-related conditions." , "study-name" : "Population-based study on salivary microbiome of Japanese adults" , "data-origination" : "HARVESTED" , "last-update" : "2018-04-26T09:01:59" }, "relationships" : { "biomes" : { "links" : { "related" : " https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002355/biomes " }, "data" : [ { "type" : "biomes" , "id" : "root:Host-associated:Human:Digestive system:Oral:Saliva" , "links" : { "self" : " https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Human:Digestive%20system:Oral:Saliva " } } ] }, "analyses" : { "links" : { "related" : " https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002355/analyses " } }, "samples" : { "links" : { "related" : " https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002355/samples " } }, "geocoordinates" : { "links" : { "related" : " https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002355/geocoordinates " } }, "publications" : { "links" : { "related" : " https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002355/publications " } }, "downloads" : { "links" : { "related" : " https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002355/downloads " } } }, "links" : { "self" : " https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002355 " } } ], "meta" : { "pagination" : { "page" : 1 , "pages" : 1 , "count" : 1 } } } MGnify is part of the ELIXIR infrastructure Submit, analyse, discover and compare microbiome data × Filters Field filters Study, ENA or BioProject accession: Study, ENA or BioProject accession Biome name: Biome name Biome lineage: --------- root root:Engineered root:Engineered:Biogas plant root:Engineered:Biogas plant:Wet fermentation root:Engineered:Bioreactor root:Engineered:Bioreactor:Continuous culture root:Engineered:Bioreactor:Continuous culture:Marine intertidal flat sediment 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Analysis of carotenoids in fruit of different apricot accessions reveals large variability and highlights apricot as a rich source of phytoene and phytofluene Download Citation | Analysis of carotenoids in fruit of different apricot accessions reveals large variability and highlights apricot as a rich source of phytoene and phytofluene | Introduction : Carotenoids are tetraterpene pigments which have a major impact on fruit color and nutritional value. Very little is known about... | Find, read and cite all the research you need on ResearchGate Analysis of carotenoids in fruit of different apricot accessions reveals large variability and highlights apricot as a rich source of phytoene and phytofluene Abstract Introduction : Carotenoids are tetraterpene pigments which have a major impact on fruit color and nutritional value. Very little is known about the carotenoids' profile and the extent of its variation within different apricot (Prunus armeniaca) accessions. Materials and methods : We analyzed carotenoid content and composition, as well as color criteria, of fruit from 113 different apricot accessions from the Newe Ya'ar germplasm collection in Israel. Results and discussion : Apricot fruit contains a unique profile of carotenoids consisting mainly of β-carotene, phytoene and phytofluene, and small amounts of other intermediates of the biosynthesis pathway, including cis-lyco-pene. The different accessions show great variability in total carotenoid content (5-95 μg g⁻¹ fresh weight) as well as in carotenoid composition. The percentage of β-carotene, phytoene and phytofluene varies between 2 to 67%, 6 to 59% and 12 to 44% respectively. Conclusion : Our findings highlight apricot as one of the richest natural sources of the colorless carotenoids phytoene and phytofluene, whose health benefits were recently noted. The distinctive carotenoid profile alongside the high diversity in fruit carotenoid composition and content among apricot varieties can assist future breeding programs and may help in understanding the factors contributing to color and nutritional traits of apricot fruit. ... The fruits are rich for five different phenolic compounds (chlorogenic acid, syringic acid, quercetin 3-rutinoside, catechin, and epicatechin) [18]. The apricot is known to be a rich source of carotenoids, especially β-carotene, which represents 50% of the total carotenoids in the fruit [19, 20] . Sucrose was the predominant sugar in the apricot fruits at harvest. ... ... In Spain, Ruiz et al. [19] reported a total carotenoid content between 1.5 and 16.5 mg/100 g among diverse apricot cultivars. In Israel, Shemesh et al. [20] reported it between 0.5 and 9.5 mg/100 g among apricot cultivars. In Turkey, Gecer et al. [10] reported total carotenoid content between 1.1 and 12.5 mg/100 g in wild apricots. ... Evaluation of Nutritional Content in Wild Apricot Fruits for Sustainable Apricot Production Apricot (Prunus armeniaca L.) trees are common from Asia to North America and have been used for delicious and nutritious fruits for centuries. Wild apricot trees show great environment plasticity and are free of pest and disease traits, both of which are important for sustainable apricot production. However, wild apricots are more common in Asia and North African countries. Wild apricot trees and fruits show great variability due to seed propagation characteristics. Seeds of wild apricots are used as rootstocks for apricot cultivars, in particular in main apricot producer countries such as Turkey, Uzbekistan, and Iran. Fruits of wild apricots are also an important food in wild apricot growing countries and add value as a sustainable nutrition source. In the present study, a total of 14 wild apricots widely grown in inner Anatolia were characterized by morphological (fruit weight, flesh/seed ratio, fruit firmness, and color index), nutritional (individual sugars and organic acids) and nutraceutical (total phenolic, total flavonoids, total carotenoid, and antioxidant activity) features. The obtained results showed that wild apricot genotypes differed from each other for most of the morphological, nutritional, and nutraceutical characteristics. The genotypes were found pest- and disease-free and had fruit weight, flesh/seed ratio, and fruit firmness of between 18.24 and 27.54 g; 8.96 and 12.44; and 4.05 and 6.03 kg/cm2, respectively. Citric acid was the dominant organic acid for fruits of all wild apricot genotypes, and ranged from 923 to 1224 mg/100 g. Sucrose was the highest soluble sugar in fruits for all wild apricots, and ranged from between 6.80 and 8.33 g/100 g. Moreover, the level of nutraceutical parameters also varied among genotypes and high amounts of total phenol and antioxidant activity were obtained in fruit extracts of IA8 genotype as 81.4 mg gallic acid equivalent per 100 g and 2.44 μmoL trolox equivalent per g, respectively. Different wild apricot genotypes are rich in certain nutritional and nutraceutical compounds, with significant variations in their levels being observed. The aim of the study was to evaluate fruits of wild apricot genotypes in terms of their total phenolics, antioxidants, and other bioactive compounds for use in future breeding programs and sustainable food and pharma industries. ... Milosevic et al. (2010) reported that apricot genotypes had different fruit flesh and skin color and they found yellow, orange, deep orange flesh color and yellow, light orange, orange and deep orange skin color among 14 apricot genotypes in Serbia. Shemesh et al. (2017) used 113 apricot accessions for morphological and biochemical analysis in Israel and they reported that fruit from different accessions exhibited a wide range of external and flesh color values. ... ... The cv. Aprikoz had 5.9 mg/100 g total carotenoid (Table 4). Ruiz et al. (2005) reported total carotenoid content between 1.5 and 16.5 mg/100 g among thirty-seven apricot cultivars in Spain and Shemesh et al. (2017) found total carotenoid content between 0.5 and 9.5 mg/100 g among one hundred-thirteen apricot cultivars in Israel. These studies are in harmony with our results. ... Physicochemical characteristics of wild and cultivated apricots (Prunus armeniaca L.) from Aras valley in Turkey GENET RESOUR CROP EV Mustafa Kenan Geçer Tuncay Kan Muttalip Gundogdu Halil ibrahim Sağbaş In east Anatolia region in Turkey, there are special microclimates, which famous for its fruit production. One of the most important microclimates in the region is Aras valley. The major fruit in the valley is apricot, which grown both cultivated and wild forms. This study aimed to assess some important fruit morphological and biochemical characteristics of 26 wild apricots and cv. Aprikoz grown in Kagizman district in Aras valley. Harvest date, tree growth habit, fruit weight, fruit shape, fruit firmness, fruit color, flesh/seed ratio, aroma, kernel taste, soluble solid content, titratable acidity, maturity index, vitamin C, total phenolic, total carotenoid and antioxidant capacity were determined. The wild grown apricots exhibited a wide variation on most of the fruit morphological and biochemical characteristics. Harvest date, fruit shape, fruit weight, fruit firmness and fruit color were the most distinct morphological characteristics of wild grown apricots. Harvest dates and fruit weight were found between 02 July (KA18) and 06 August (KA13); 16.28 g (KA6) and 33.14 g (KA2) among wild grown apricots, respectively. The main cultivar cv. Aprikoz harvested at 04 July and had 38.67 g fruit weight. The wild apricots had flesh/seed ratio between 8.41 (KA21) and 12.25 (KA10) while cv. Aprikoz had 11.69 flesh/seed ratio. Total antioxidant capacity, total carotenoid and total phenolic content were the highest in most of wild apricot fruits than cv. Aprikoz. Our results showed that there is potential for promoting wild apricot fruit from specific geographical regions because they contained elevated concentrations of antioxidant polyphenolic compounds. ... The total ascorbic acid content in plums was reported to be 454 mg/100 g FW [23]. An evaluation of the carotenoid content in apricots showed that three main carotenoids were present, namely β-carotene (2% to 67% of the total carotenoid content), phytoene (6-59%), and phytofluene (12-45%) [50] Research-Gap-Spotting in Plum-Apricot Hybrids-Bioactive Compounds, Antioxidant Activities, and Health Beneficial Properties Svetla Pandova Pavlina Doykina Plum-apricot hybrids are successful backcrosses of plums and apricots resulting in plum-cots, pluots, and apriums. A topic search on plums, apricots, and plumcots shows that extensive information exists on the agro-morphology, genotyping, bioactive substances, and nutritive value of the genus Prunus, and plums and apricots, in particular. However, when search results for plum-apricot hybrids were evaluated for the period 2010-2023, only a few papers focused partially on the topic of their metabolomics. A database search (Scopus, PubMed, and Google Scholar) exposed that less than 10 articles/year appeared in Scopus on the topic of plum-apricot hybrids, 618 papers were found on Google Scholar (2010-2023), and only 2 results were found in PubMed for the same period using the same keywords. This shows the grand research opportunity and the need for providing a thorough chemical characterization of the existing plum-apricot hybrids. This review aims at schematizing the available information about plum-apricot hybrids (with reference to their parents), identifying the gaps about their bioactive compounds, antioxidant activities, and health beneficial properties, as well as pointing to future perspectives in terms of fruit hybrid characterization. ... From the max-min, the water content and vacuum degree were the most obvious factors affecting the formation of 5-HMF, while the vacuum drying temperature and vacuum degree were the most obvious factors affecting the A420 value [52]. A high value of a* indicated that the color of the tomato powder was reddish, and high values of L* and b* indicated that the color of the tomato powder was yellowish (Table A4) [53] . Generally speaking, tomato powder with a significantly higher A420 had a lower a* value. ... Study on the Drying Technology of Tomato Pulp with Phytoene, Phytofluene and Lycopene Retention as Inspection Indexes Full-text available Oct 2022 Liying Li Cheng Yang Jian Zhang Lianfu Zhang The objective was to design a feasible drying method to increase the retention rates of phytoene (PT), phytofluene (PTF) and lycopene (LYC) in tomato powder. The method was to compare the effects of vacuum freeze-drying (FD), vacuum drying (VD) and hot-air drying (HAD) technologies on tomato pulp rich in PT, PTF and LYC. When dried by HAD, the retention rates of PT, PTF and LYC decreased significantly (p < 0.05) only when the water content decreased from 30% to 3.5%. When dried by VD, the temperatures had no significant effect on the retention rates, and only alkaline conditions (pH = 9), Fe3+ and Al3+ could significantly reduce the retention rates (p < 0.05). Therefore, a combined drying process (CDP) was designed: before the water content decreased to 50%, HD (60 °C) technology was used; then, the paste was dried via VD (80 °C, 0.08 MPa) technology till the water content reached 5 ± 2%; loading weight was 40 g (thinkness 5.70 mm) for each batch. Compared with VD alone, the CDP technology improved the retention rates of PT and LYC by 12% and 36%, respectively, while PTF decreased by only 6%. ... Ruiz et al. [65] found total carotenoid content between 1.5 and 16.5 mg/100 g among a large number of apricot cultivars in Spain. Shemesh et al. [66] found total carotenoid content between 0.5 and 9.5 mg/100 g among 113 apricot cultivars in Israel. These studies are in harmony with our results. ... Assessment of Morphological Traits, Nutritional and Nutraceutical Composition in Fruits of 18 Apricot cv. Sekerpare Clones Full-text available Oct 2021 Neva Karatas Sezai Ercisli Mehmet Ramazan Bozhuyuk Apricot (Prunus armeniaca L.) is one of the most important members of Prunus and its trees bears delicious and nutritious fruits during summer months in the temperate zones in the world. Apricot cultivars are propagated asexually which consists of clones. Information on inter-clonal variations in apricot cultivars can assist us in the selection of better clones from commercial cultivars. We aimed to determine morphological traits (fruit weight, seed weight, kernel weight, flesh/seed ratio, shape index, fruit firmness, color index), nutritional (sugars and organic acids) and nutraceutical (total phenolic, total flavonoids, total carotenoid and antioxidant activity) composition of 18 clones of Sekerpare apricot cultivar grown together in Kagizman district in eastern Turkey. Results showed significant differences among clones concerning most of the morphological traits, nutritional and nutraceutical compositions. Fruit weight, flesh/seed ratio and fruit firmness of clones were in range of 23.14–27.11 g, 11.21–13.14 and 3.88–5.11 kg/cm2, respectively. Fruit shape index was slightly similar among all clones which was between 0.95 and 1.03. Citric acid and sucrose were found to be the predominant organic acid and sugar among clones which varied from 728 to 915 mg/100 g and 7.11 to 9.94 g/100 g, respectively. The clone ‘KS2’ exhibited the highest level of total phenol (67.1 mg gallic acid equivalent per 100 g) and antioxidant activity (2.16 μmol trolox equivalent per g). The study confirmed the diversity among Sekerpare clones and effectiveness of combining morphological, nutritional and nutraceutical analyses in assessment of Şekerpare clones and its use for future pre-breeding programs. ... It is noteworthy, that in "wild type" M82 tomato [78] and apricot (var. Pazza) [92] , pro-lycopene was detected in addition to phytoene, phytofluene, and ζ-carotene. In varieties or tissues that accumulate ζ-carotene, neurosporene and/or pro-lycopene it seems likely that a perturbation/regulation in the activity of Z-ISO, ZDS or CRTISO would enable these cis-carotenes to accumulate. ... A cis -carotene derived apocarotenoid regulates etioplast and chloroplast development Preprint Full-text available Jan 2019 Christopher I Cazzonelli Xin Hou Yağız Alagöz Barry J Pogson Carotenoids are core plastid components, yet a regulatory function during plastid biogenesis remains enigmatic. A unique carotenoid biosynthesis mutant, carotenoid chloroplast regulation 2 ( ccr2 ), that has no prolamellar body (PLB) and normal PROTOCHLOROPHYLLIDE OXIDOREDUCTASE (POR) levels, was used to demonstrate a regulatory function for carotenoids under varied dark-light regimes. A forward genetics approach revealed how an epistatic interaction between a (-carotene isomerase mutant ( ziso-155 ) and ccr2 blocked the biosynthesis of specific cis -carotenes and restored PLB formation in etioplasts. We attributed this to a novel apocarotenoid signal, as chemical inhibition of carotenoid cleavage dioxygenase activity restored PLB formation in ccr2 etioplasts during skotomorphogenesis. The apocarotenoid acted in parallel to the transcriptional repressor of photomorphogenesis, DEETIOLATED1 (DET1), to post-transcriptionally regulate PROTOCHLOROPHYLLIDE OXIDOREDUCTASE (POR), PHYTOCHROME INTERACTING FACTOR3 (PIF3) and ELONGATED HYPOCOTYL5 (HY5) protein levels. The apocarotenoid signal and det1 complemented each other to restore POR levels and PLB formation, thereby controlling plastid development. One-sentence summary Carotenoids are not just required as core components for plastid biogenesis, they can be cleaved into an apocarotenoid signal that regulates etioplast and chloroplast development during extended periods of darkness. ... It is noteworthy, that in "wild type" M82 tomato [78] and apricot (var. Pazza) [92] , pro-lycopene was detected in addition to phytoene, phytofluene, and ζ-carotene. In varieties or tissues that accumulate ζcarotene, neurosporene and/or pro-lycopene it seems likely that a perturbation/regulation in the activity of Z-ISO, ZDS or CRTISO would enable these cis-carotenes to accumulate. ... cis -carotene biosynthesis, evolution and regulation in plants: The emergence of novel signaling metabolites Article Jul 2018 Yağız Alagöz Pranjali Nayak Namraj Dhami Christopher I Cazzonelli Carotenoids are isoprenoid pigments synthesised by plants, algae, photosynthetic bacteria as well as some non-photosynthetic bacteria, fungi and insects. Abundant carotenoids found in nature are synthesised via a linear route from phytoene to lycopene after which the pathway bifurcates into cyclised α- and β-carotenes. Plants evolved additional steps to generate a diversity of cis-carotene intermediates, which can accumulate in fruits or tissues exposed to an extended period of darkness. Enzymatic or oxidative cleavage, light-mediated photoisomerization and histone modifications can affect cis-carotene accumulation. cis-carotene accumulation has been linked to the production of signaling metabolites that feedback and forward to regulate nuclear gene expression. When cis-carotenes accumulate, plastid biogenesis and operational control can become impaired. Carotenoid derived metabolites and phytohormones such as abscisic acid and strigolactones can fine-tune cellular homeostasis. There is a hunt to identify a novel cis-carotene derived apocarotenoid signal and to elucidate the molecular mechanism by which it facilitates communication between the plastid and nucleus. In this review, we describe the biosynthesis and evolution of cis-carotenes and their links to regulatory switches, as well as highlight how cis-carotene derived apocarotenoid signals might control organelle communication, physiological and developmental processes in response to environmental change. Sustainable Fruit Growing: From Orchard to Table Book Full-text available Jan 2022 Boris Duralija The book focused on different fruit species and aspects that can promote more sustainable fruit growing in the future. The book “Sustainable Fruit Growing: From Orchard to Table” contains the following 11 commentary and research papers by 45 scientists from Australia, Bosnia and Herzegovina, Croatia, Czech Republic, Germany, Italy, Montenegro, Pakistan, Poland, Turkey and the United States: 1. Sustainable Fruit Growing: From Orchard to Table-Editorial Comentary 2. Innovative Strategies for the Use of Reflective Foils for Fruit Colouration to Reduce Plastic Use in Orchards 3. Detecting Apples in the Wild: Potential for Harvest Quantity Estimation 4. Interpreting Environmental Impacts Resulting from Fruit Cultivation in a Business Innovation Perspective 5. Chilling and Heat Accumulation of Fruit and Nut Trees and Flower Bud Vulnerability to Early Spring Low Temperatures in New Mexico: Meteorological Approach 6. Polyphenol-Based Microencapsulated Extracts as Novel Green Insecticides for Sustainable Management of Polyphagous Brown Marmorated Stink Bug (Halyomorpha halys Stål, 1855) 7. Evaluation of the Characteristics of the Native Wild Himalayan Fig (Ficus palmata Forsk.) from Pakistan as a Potential Species for Sustainable Fruit Production 8. Main Agro-Morphological and Biochemical Berry Characteristics of Wild-Grown Sea Buckthorn (Hippophae rhamnoides L. ssp. caucasica Rousi) Genotypes in Turkey 9. Sustainable Cornelian Cherry Production in Montenegro: Importance of Local Genetic Resources 10. Assessment of Morphological Traits, Nutritional and Nutraceutical Composition in Fruits of 18 Apricot cv. Sekerpare Clones 11. Determination of Selected Beneficial Substances in Peach Fruits Biochemical and Molecular Factors Governing Peel-Color Development in 'Ora' and 'Shani' Mandarins Article Apr 2019 Livnat Goldenberg Matat Zohar Lina Kirshinbaum Tal Isaacson To identify factors governing peel-color development in mandarins, we examined carotenoid content and composition and the expression of carotenoid-related genes during four stages of ripening (i.e., green, breaker, yellow and orange) in two varieties: ‘Ora’, which has orange fruit, and ‘Shani’, which has orange-reddish fruit. The two varieties had different carotenoid compositions and ‘Shani’ had a significantly higher level of total carotenoid pigments. ‘Shani’ was rich in the deep orange β-cryptoxanthin and the orange-reddish β-citraurin; whereas ‘Ora’ was rich in the orange violaxanthin. RNA-Seq analysis revealed significantly greater expression of the carotenoid-biosynthesis genes PSY, βLCY, βCHX and CCD4b, as well as MEP-pathway genes and several ethylene-biosynthesis and -signaling genes in ‘Shani’ fruit. In contrast, the expression levels of genes involved in the synthesis of α-branch carotenoids (i.e., εLCY and εCHX) and ZEP, which is involved in the formation of violaxanthin, were significantly higher in the ‘Ora’ fruit. Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases – A Critical Review Feb 2015 Lars Müller Catherine Caris-Veyrat Gordon M Lowe Volker Böhm The present review is based mainly on papers published between 2000 and 2011 and gives information about the properties of the carotenoid lycopene in chemical and biological systems and its possible role in preventing cardiovascular diseases (CVD). The main aim of this report is to highlight its role as an antioxidant, also reported are bioactive properties that may influence the development of foam cells and protection against endothelial cell damage. The paper will also examine recent observations that lycopene may improve blood flow and reduce inflammatory responses. Lycopene possesses antioxidant properties in vitro, and some epidemiological studies have reported protective effects against the progression of CVD. The oxidation of human low density lipoproteins (LDL) is a fundamental mechanism in the initiation of atherosclerosis. A beneficial role of lycopene as antioxidant in the prevention of CVD is suggested but the data are still controversial. Lycopene is believed to be the most potent carotenoid antioxidant in vitro. Tissue culture experiments and animal studies support potential cardioprotective effects for lycopene and other carotenoids in the blood. Most studies showed beneficial effects of lycopene to individuals who are antioxidant-deficient like elderly patients, or humans exposed to higher levels of oxidative stress like smokers, diabetics, hemodialysis patients and acute myocardial infarction patients. By defining the right population and combining antioxidant potentials of lycopene with vitamins and other bioactive plant compounds, the beneficial role of lycopene in CVD can be clarified in future studies. Inactivation of a Gene Encoding Carotenoid Cleavage Dioxygenase (CCD4) Leads to Carotenoid-Based Yellow Coloration of Fruit Flesh and Leaf Midvein in Peach Feb 2014 Juanjuan Ma Jing Li Jianbo Zhao Yuepeng Han Yellow fruit flesh color, resulting from the accumulation of carotenoids, is one of the most important commercial traits of peach. Yellow flesh is controlled by a single locus (Y), with white flesh dominant over yellow flesh. In this study, the Y locus was narrowed to a 2.6-cM interval flanked by two markers, SSRy and W2691. SSRy, which is located on the first exon of a gene encoding carotenoid cleavage dioxygenase (CCD4), was cosegregated with the Y locus in two peach F1 populations. RNA-Seq and qRT-PCR analysis revealed transcript level of CCD4 was consistent with carotenoid degradation in peach fruits. All these results suggest that CCD4 is responsible for white and yellow coloration of peach fruit flesh. In fruits of white-fleshed peach, carotenoids are synthesized but subsequently degraded into colorless compounds, leading to the formation of white color. CCD4 is likely to utilize β-carotene as the substrate in peach. Interestingly, CCD4 also controls white and yellow coloration of leaf midveins of peach. Moreover, LCYE was highly expressed in peach leaves, whereas its transcript was not detectable in fruits. This suggests the difference of carotenoid biosynthesis between peach fruits and leaves. Our study not only shows for the first time the pleiotropic effects of CCD4 gene in peach but also provides a morphological marker for easy selection of new peach cultivars with desirable white or yellow flesh colors.
https://www.researchgate.net/publication/319468504_Analysis_of_carotenoids_in_fruit_of_different_apricot_accessions_reveals_large_variability_and_highlights_apricot_as_a_rich_source_of_phytoene_and_phytofluene
Cells | Free Full-Text | Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is responsible for a cell’s fate. Due to the recognized relevance of this family in cancer progression and response to therapy, different efforts have made in recent years in order to develop small molecules able to target anti-apoptotic proteins such as Bcl-2, Bcl-xL and Mcl-1. The limitations of the first Bcl-2 family targeted drugs, regarding on-target and off-target toxicities, have been overcome with the development of venetoclax (ABT-199), the first BH3 mimetic inhibitor approved by the FDA. The purpose of this review is to discuss the state-of-the-art in the development of drugs targeting Bcl-2 anti-apoptotic proteins and to highlight the potential of their application as single agents or in combination for improving anti-cancer therapy, focusing in particular on solid tumors. Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer by Simona D’Aguanno * and Donatella Del Bufalo Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy Author to whom correspondence should be addressed. Cells 2020 , 9 (5), 1287; https://doi.org/10.3390/cells9051287 Received: 28 April 2020 / Revised: 18 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020 (This article belongs to the Special Issue Regulation of Apoptosis by the Bcl-2 Family of Proteins ) The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is responsible for a cell’s fate. Due to the recognized relevance of this family in cancer progression and response to therapy, different efforts have made in recent years in order to develop small molecules able to target anti-apoptotic proteins such as Bcl-2, Bcl-xL and Mcl-1. The limitations of the first Bcl-2 family targeted drugs, regarding on-target and off-target toxicities, have been overcome with the development of venetoclax (ABT-199), the first BH3 mimetic inhibitor approved by the FDA. The purpose of this review is to discuss the state-of-the-art in the development of drugs targeting Bcl-2 anti-apoptotic proteins and to highlight the potential of their application as single agents or in combination for improving anti-cancer therapy, focusing in particular on solid tumors. Keywords: cancer ; Bcl-2 ; inhibitors Graphical Abstract 1. Introduction Apoptosis is a deeply studied form of programmed cell death that triggers cells to suicide through proteolysis of some key cellular components, which renders cells prone to be recognized by phagocytes [ 1 ] The two mechanisms of apoptotic induction are the “death receptor” or “extrinsic” pathway activated by exogenous death-inducing ligands, and the “mitochondrial” or “intrinsic” pathway induced by stress conditions [ 1 ]. The intrinsic apoptotic pathway is mediated and regulated by the balance of pro- and anti-apoptotic members of the B cell lymphoma-2 (Bcl-2) family of proteins, and results in alteration of mitochondrial outer membrane permeabilization (MOMP), release of cytochrome c from the mitochondria into cytosol, assembly of the APAF-1 containing apoptosome and activation of the caspase cascade through caspase-9 [ 2 , 3 ]. Bcl-2 family members, characterized by the presence of short conserved sequence regions (Bcl-2 homology [BH] motifs), are classified into three subgroups: the anti-apoptotic/pro-survival proteins, including Bcl-2, Bcl-xL, Mcl-1, Bcl-w, Bcl-B, and A1/Bfl-1; the pro-apoptotic BH3-only proteins, such as Bim, Bid, Bad, Noxa, Puma, and Bmf; and the multidomain pro-apoptotic proteins, such as Bax and Bak [ 4 ]. The pro-survival protein subgroup is characterized by the existence of the N-terminal BH4 domain [ 5 ]. The BH4 domain of Bcl-2 and Bcl-xL is able to bind other proteins that do not belong to Bcl-2 protein family, allowing them to play a role beyond their classical role in inhibiting apoptosis, in other important cellular functions such as proliferation, autophagy, differentiation, DNA repair, tumor progression, and angiogenesis [ 6 ]. The anti-apoptotic Bcl-2 family proteins exert their pro-survival function by binding and inhibiting the pro-apoptotic proteins, the sensors of cellular stress (the BH3-only proteins) and the effectors of apoptosis (Bax and Bak) [ 7 ]. From a biochemical point of view the interaction between pro- and anti-apoptotic proteins takes place via the binding of the hydrophobic face of the amphipathic BH3 α-helix from the pro-apoptotic protein into a hydrophobic pocket in the anti-apoptotic protein formed by the BH1, BH2 and BH3 domains [ 8 ]. Anti-apoptotic proteins Bcl-2 ( Figure 1 ), Bcl-xL ( Figure 2 ) and Mcl-1 ( Figure 3 ) are expressed in a wide range of tumor histotypes, with different extent regarding mRNA and protein levels, by The Human Protein Atlas database ( https://www.proteinatlas.org/ ). A deregulated expression of several Bcl-2 family members has been observed in cancers from different origin [ 9 ]. Moreover, several studies, including ours, have found that high levels of anti-apoptotic proteins contribute not only to modulation of apoptosis and response to chemotherapy, but also to tumor initiation and progression [ 6 , 10 ]. Since the discovery of Bcl-2, the founding member of the family, many papers have been published regarding the role that Bcl-2 anti-apoptotic members play in cancer and in drug resistance, as well as on their use for cancer therapy. In this regard, a comprehensive representation of the published papers on PubMed ( https://pubmed.ncbi.nlm.nih.gov/ ) since Bcl-2 discovery is reported in Figure 4 . Due to their multiple functions in cancer, Bcl-2 family proteins have become interesting targets for anti-cancer drugs. The purpose of this review is to discuss the role of the main Bcl-2 anti-apoptotic proteins in solid cancer, to outline how Bcl-2 family regulation is positioned within the context of cancer treatment and to discuss the potential of Bcl-2 family inhibitors for cancer therapy with the aim of improving patient survival. Given the high volume of information about the relevance of Bcl-2 inhibitors in hematologic malignancies, including acute myeloid leukemia (AML), mature B-Cell malignancies and lymphoid malignancies [ 11 , 12 , 13 ], this article will focus mainly on Bcl-2 inhibitor application in solid tumors. 2. Relevance of Bcl-2 Anti-Apoptotic Family Proteins in Cancer 2.1. Bcl-2 The tumorigenic effect of Bcl-2 was first described in subsets of non-Hodgkin’s lymphoma (NHL), such as AML, where it has been found to be associated with chemoresistance and unfavorable outcomes [ 14 , 15 , 16 ]. Evidence that Bcl-2 may have also oncogenic potential in carcinoma was first provided in prostate cancer, where high expression of the protein was found in androgen-independent tumors [ 17 ]. In subsequent studies, increased Bcl-2 expression has been reported in many different solid tumor histotypes, including ovarian [ 18 ], breast [ 19 ] and lung [ 20 ] carcinoma, and melanoma [ 21 , 22 ]. Increased levels of Bcl-2 expression have been also associated with resistance to different drugs including 5-fluorouracil in gastric cancer [ 23 ] cisplatin in ovarian cancer [ 24 ] and doxorubicin in osteosarcoma and chondrosarcoma [ 25 , 26 ]. In the last years, our group demonstrated that, in addition to its important role in the regulation of apoptosis and chemoresistance [ 27 ], Bcl-2 modulates in vitro and in vivo tumor migration, invasion, autophagy and angiogenesis [ 28 , 29 , 30 , 31 , 32 , 33 ], promotes a cancer stem-like cell phenotype [ 34 ], regulates the expression of microRNA and the activity of several transcription factors and their specific target genes [ 35 , 36 , 37 ], controls an interleukin-1β-driven axis of macrophage diversion that establishes tumor microenvironmental conditions favoring melanoma development [ 38 ] and is involved in mitochondrial mRNA homeostasis [ 39 ]. We and other authors demonstrated several non-canonical functions of Bcl-2, as well as other anti-apoptotic proteins, in an apoptosis-independent manner [ 40 ]. Bcl-2 expression in cancer patient samples is also associated with cancer progression, including liver metastatization in colorectal cancer [ 41 , 42 ], lymphovascular invasion of breast cancer [ 43 , 44 ] and gastric cancer staging [ 45 ]. Moreover, Bcl-2 upregulation is particularly evident during the progression from pre-invasive lesions to invasive carcinoma in lung cancer samples [ 46 ]. 2.2. Bcl-xL (BCL2-like 1 Gene, BCL2L1) Two isoforms of Bcl-X cDNA, Bcl-xL and Bcl-xS, with opposite functions in terms of apoptosis regulation, have been identified. Bcl-xL is an anti-apoptotic protein sharing similar structural domains with Bcl-2, while Bcl-xS, lacking the region with the highest homology to Bcl-2, promotes apoptosis [ 47 ]. Different mechanisms are responsible for the alternative splicing, including cellular stress, DNA damage, protein synthesis stalling and protein kinase C inhibition [ 48 ]. We and others previously reported the link of Bcl-xL protein expression not only with drug resistance in different tumor histotypes [ 27 ] , but also with tumor-associated properties, including angiogenesis and cancer cell stemness [ 34 , 49 , 50 , 51 , 52 ]. Recently, it has been demonstrated that Bcl-xL, interacting with Voltage-dependent anion-selective channel 1 through its BH4 domain, favors cell migration by promoting reactive oxygen species in breast cancer models [ 53 ]. In tumor patient samples, Bcl-xL upregulation has been reported to correlate with invasion and metastasis in retinoblastoma [ 54 ], melanoma [ 55 ], breast [ 56 ], colon [ 57 ], tongue [ 58 ] and hepatocellular [ 59 ] carcinoma. 2.3. Mcl-1 (Myeloid Leukemia Sequence 1) 3. Anti-Apoptotic Bcl-2 Family Protein Inhibitors 3.1. Antisense Oligonucleotides The first strategy followed in the attempt to inhibit the function of anti-apoptotic Bcl-2 family proteins was to design antisense oligonucleotides directed against the mRNA of the protein of interest. The dual Bcl-2/Bcl-xL and the specific Bcl-xL antisense oligonucleotides were tested by us and other groups in in vitro and in vivo preclinical models [ 49 , 73 , 74 , 75 ]. Oblimersen (genasense, G3139), the specific antisense oligonucleotide drug directed against Bcl-2, was the first compound to reach clinical study. After the failure of oblimersen as a single agent, its efficacy in combination with other drugs was evaluated in several Phase I–III clinical trials in patients with advanced solid malignancies, but they were discontinued [ 76 , 77 , 78 , 79 ]. A list of completed clinical trials with oblimersen is reported in Supplementary Table S1 . 3.2. BH3 Mimetics In the past decades, different efforts have been made in order to understand the network of protein-protein interactions involved in the regulation of apoptosis mediated by Bcl-2 family members. The understanding of the interaction among Bcl-2 family members has been the foundation of drug discovery approaches, based on innovative medicinal chemistry and structure-based drug design, with the aim of generating small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins, which mimic the function of the BH3-only proteins to kill cancer cells [ 80 ]. The BH3 mimetics class of inhibitors is mainly represented by molecules with low level of specificity and high affinity for different anti-apoptotic Bcl-2 proteins, although in recent years specific Bcl-2 protein inhibitors have been developed. A schematic list of BH3 mimetics is reported in Figure 5 . Despite significant efforts, ten BH3-mimetic drugs (obatoclax, AT-101, ABT-263 (navitoclax), APG-1252, AZD0466, venetoclax, S55746, AMG-176, AZD5991 and S64315/MIK665) have reached clinic with only the Bcl-2 inhibitor venetoclax currently approved by FDA [ 81 , 82 ]. 3.2.1. Rationale for the Use of BH3 Mimetics (Priming and Protein Addiction) Cancer cell dependency on specific anti-apoptotic Bcl-2 proteins could be explained by multiple factors, including tissue of origin, impact of the oncogenic lesions that drove tumorigenesis, and/or factors produced by the tumor stroma [ 82 ]. Anti-apoptotic proteins are often expressed at high levels in cancer cells, forming high numbers of complexes with their pro-apoptotic counterparts, a condition described by the concept of “priming” [ 8 ]. Primed cancer cells are more sensitive to BH3 mimetics (and other anti-cancer agents) compared with their “normal” counterparts [ 8 ]. The relative expression levels between anti-apoptotic Bcl-2 family members and pro-apoptotic BH3 only proteins were found to correlate with sensitivity to BH3-mimetic drugs [ 83 ]. The “protein addiction” phenomenon, the dependence of response to drugs in tumor cells on the expression level of members of an anti-apoptotic family, is mostly linked to a single pro-survival protein in leukemia and lymphoma, while in solid tumors it is often associated with multiple anti-apoptotic protein levels [ 82 , 84 ]. Dependencies of tumor cells on anti-apoptotic Bcl-2 family members can be experimentally determined by the so-called “dynamic BH3 profiling”, where BH3 peptides specific for individual BH3-only proteins are applied to permeabilized cells and allowed to interact with other BH3-containing proteins on the surface of the mitochondria, generating MOMP, after allowing Bax or Bak oligomerization [ 8 ]. Other experimental approaches could be the use of inducible CRISPR/Cas9 platform [ 85 ] or culturing malignant cells from the patient with different BH3-mimetic drugs [ 86 ]. 3.2.2. Multitarget BH3 Mimetics The first generation of BH3 mimetics had limited selectivity for a specific anti-apoptotic Bcl-2 protein and most of them were also found to promote cell death independently of Bax/Bak proteins. The pan BH3 inhibitor obatoclax (GX15-070), showing affinity for Bcl-2, Bcl-xL, Mcl-1, Bcl-w, A1/Bfl-1 [ 87 ] and the R-(-) enantiomer of gossypol acetic acid, AT-101, able to bind to Bcl-2, Bcl-xL and Mcl-1 [ 88 ], was were evaluated in Phase I/II clinical trials in hematological malignancies and in solid tumors, including small-cell lung cancer (SCLC) and metastatic melanoma in the case of obatoclax (listed in Supplementary Table S2 ) and lung cancer, prostate cancer, squamous cell carcinoma of the head and neck and brain and central nervous system tumors in the case of AT-101 (listed in Supplementary Table S3 ). Due to significant toxicities associated with off-target effects, further development of both obatoclax and AT-101 was halted [ 89 , 90 ]. Preclinical studies demonstrated that sabutoclax (BI-97C1), an apogossypol derivative and pan-active Bcl-2 protein family antagonist (inhibiting Bcl-2, Bcl-xL, Mcl-1 and A1/Bfl-1), overcame drug resistance, eliminated cancer stem cells in breast cancer [ 91 ] and synergized with minocycline, a synthetic tetracycline, in a pancreatic cancer model [ 92 ] and with docetaxel in a model of prostate cancer [ 93 ]. ABT-737 was one of the pioneer BH3 mimetics [ 94 ]. It is a small-molecule inhibitor of Bcl-2, Bcl-xL and Bcl-w resulting from the combination of nuclear magnetic resonance-based screening, parallel synthesis and structure-based design. The mechanism of action was demonstrated in chronic lymphocytic leukemia (CLL) cells [ 95 ], but its efficacy and synergistic cytotoxicity with chemotherapeutics and radiation was also reported for solid tumors including SCLC [ 94 ]. In preclinical models of lung cancer, ABT-737 in combination with the inhibition of Notch by the use of GSI, a γ-secretase inhibitor, showed a synergistic antitumor effect in vitro and significantly suppressed tumor proliferation compared to the single drug treatment in vivo [ 96 ]. Studies conducted in melanoma models demonstrated the ability of ABT-737 to empower the efficacy of several therapeutic strategies including immunotoxins [ 97 ] and BRAF or MEK inhibitor in BRAF-mutated cells [ 98 ]. Being not orally bioavailable, ABT-737 development has been limited, and navitoclax, its orally bioavailable analog, has been developed. Navitoclax showed efficacy in vivo in xenograft models of leukemia and lymphoma [ 99 ] and in vitro in the treatment of SCLC cells [ 100 ]. Combination of navitoclax with PI3K inhibition suppressed tumor growth in both an established SCLC xenograft model and in an established circulating tumor cell-derived explant model generated from a blood sample obtained at presentation from a chemorefractory SCLC patient [ 101 ]. The efficacy of navitoclax has been reported for treatment of BRAFV600E positive in vivo melanoma models in combination with copper chelators, able to sequester copper required for MEK1 and MEK2 activity through a direct copper-MEK1/2 interaction [ 102 ]. Navitoclax effectiveness was limited by dose-dependent Bcl-xL-mediated thrombocytopenia [ 103 ]. In order to reduce the toxicity of navitoclax, new technology has been employed, converting navitoclax into DT2216, a Bcl-xL proteolysis-targeting chimera (PROTAC) that targets Bcl-xL to the Von Hippel-Lindau (VHL) E3 ligase for degradation. Since VHL is little expressed in platelets, the toxicity in these cells is reduced, while the therapeutic potential of DT2216 remains similar to those of the original molecule when evaluated in several xenograft tumors as a single agent or in combination with other chemotherapeutic agents [ 104 ]. Given the relevant role of proteins of the Bcl-2 family in regulating clonal selection and survival of lymphocytes, and their frequent overexpression in lymphomas, navitoclax progressed to clinical evaluation, firstly as single agent Phase I/II trial in patients with this malignancy [ 105 ]. Regarding its efficacy in solid tumors, navitoclax was shown to synergize with several chemotherapeutics such as doxorubicin [ 106 ] and paclitaxel [ 107 ] in triple-negative breast cancer models, with PARP inhibitor in high-grade serous ovarian cancer [ 108 ] and with TORC1/2 inhibitor in colorectal cancer [ 109 ]. At present, navitoclax is under clinical evaluation in combination with ruxolitinib, a JAK inhibitor, in myeloproliferative neoplasm (NCT04041050), myelofibrosis (NCT03222609) and lymphoid cancers (NCT00788684). Clinical trials are also ongoing using navitoclax in combination with osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in NSCLC (NCT02520778); sorafenib, a kinase inhibitor, in relapsed or refractory (R/R) solid tumors (NCT02143401); trametinib, a MEK inhibitor, in advanced or metastatic solid tumors (NCT02079740); and dabrafenib (a BRAF inhibitor)/trametinib in BRAF mutant melanoma (NCT01989585). Active clinical trials with BH3 mimetics are reported in Table 1 . 3.2.3. Dual BH3 Inhibitors: Bcl-2/Bcl-xL, Bcl-2/Mcl-1, Bcl-xL/Mcl-1 Starting from the arylsulfonamide scaffold of ABT-737/ABT-263, several dual Bcl-2/Bcl-xL inhibitors have been generated. BM-1197, in SCLC models, has been demonstrated to have potent in vitro proliferation inhibitory effect and to achieve in vivo complete and long-term tumor regression in xenograft models, associated with reversible platelet reduction at highly efficacious doses [ 110 ]. BM-1197 efficacy was also tested in human colorectal cancer, where it increased the fraction of cells in the sub-G1 phase of the cell cycle, induced apoptotic death and increased the cellular inter nucleosomal DNA fragmentation [ 111 ]. Furthermore, in malignant lymphoma cells BM-1197 induced cell death through the intrinsic apoptotic pathway [ 112 ]. S44563 was found to enhance in vitro and in vivo radiosensitivity of SCLC cells [ 113 ] and to increase the efficacy of fotemustine, a nitrosourea alkylating agent, in uveal melanoma patient-derived xenografts [ 114 ]. APG-1252 (BM-1252), a recently developed drug with high binding affinity to Bcl-2 and Bcl-xL, has been reported to induce mitochondria-dependent apoptosis in leukemia cells in vitro, to achieve complete and persistent tumor regression in multiple tumor xenograft models including ALL, SCLC and colon and breast carcinoma, and shows strong synergy with some chemotherapeutic agents [ 115 , 116 ]. Phase I trials with APG-1252 alone or in combinatorial therapy are currently ongoing for the treatment of patients with lung carcinoma or other solid tumors (NCT03080311, NCT04210037). Moreover, AZD0466, a dual Bcl-2/Bcl-xL inhibitor is under clinical evaluation in hematologic malignancies and advanced solid tumors (NCT04214093). Clinical trials with BH3 mimetics are reported in Table 1 . Single agent antitumor activity of S1, the BH3-mimetic dual inhibitor of Bcl-2 and Mcl-1, and its derivative B4, has been also reported in cancer models with different origin [ 117 ]. Starting from the natural compound meiogynin A, molecules specifically targeting Bcl-2/Mcl-1 [ 118 ] or Bcl-xL/Mcl-1 [ 119 ] have been synthesized and in vitro tested, nevertheless with limited application until now. Moreover, two PROTACs compounds have been recently developed for the selective degradation of Mcl-1/Bcl-2 [ 120 ]. The combination of BH3 mimetics targeting different anti-apoptotic proteins such as Bcl-2 and Mcl-1 or Bcl-xL and Mcl-1, has been reported to shown significant benefit for the treatment of melanoma [ 121 ]. 3.2.4. Bcl-2 Specific Inhibition The turning point in the research for Bcl-2 inhibitors was reached with the development of venetoclax, a potent and selective BH3 mimetic for Bcl-2 protein, which was able to circumvent the thrombocytopenia observed with navitoclax [ 122 ]. The first FDA approval for venetoclax in first-line treatment of patients with the R/R CLL and carrying the 17p deletion came in 2016 [ 123 ]. Subsequently, in June 2018, the clinical practice of venetoclax was introduced by the FDA for patient with CLL or small lymphocytic lymphoma, regardless of 17p deletion. After the first excellent findings, venetoclax was tested in combination, with satisfactory results, in different hematological malignancies [ 11 , 12 , 13 , 124 ]. In November 2018, the FDA approved the use of venetoclax in combination with hypomethylating drugs azacitidine, decitabine or low-dose cytarabine for the treatment of newly-diagnosed AML in adults who are aged 75 years or older, or who have comorbidities that preclude use of intensive chemotherapy. In January 2019, the impressive results of the Murano Phase III trial [ 125 ] prompted the European Commission to approve the combination of venetoclax/rituximab for patients with R/R CLL, previously treated without success. Other combination therapies have been evaluated in clinical trials in hematological tumors. In CLL, venetoclax was evaluated in combination with obinutuzumab, an anti-CD20 monoclonal antibody, in Phase Ib [ 126 ], or with ibrutinib, an inhibitor of Bruton’s tyrosine kinase, in Phase II [ 127 , 128 ]. Venetoclax showed activity in a Phase I trial in multiple myeloma (MM) patients carrying t(11;14) with multiple prior lines of therapy as single agent [ 128 ] and in combination with bortezomib, a proteasome inhibitor, and dexamethasone in a Phase Ib study [ 129 ]. In a small cohort of patients affected by R/R AML and treated with venetoclax as single agents, subjects with isocitrate dehydrogenase (IDH) 1/2 mutations were found to have better response in respect to patients carrying the wild type gene [ 130 , 131 ]. Venetoclax in combination with navitoclax and chemotherapy is under evaluation in subjects with R/R ALL or R/R LL (NCT03181126). Mechanisms of resistance to venetoclax have been identified in G101V-mutated Bcl-2 proteins in CLL patients [ 132 ], thus emphasizing the need to persevere in research of Bcl-2 inhibitors. In 2019, the first clinical study evaluating the efficacy of venetoclax in solid tumors demonstrated that the combination of venetoclax with tamoxifen showed a tolerable safety profile and activity in estrogen-receptor and Bcl-2-positive metastatic breast cancer [ 133 ]. Several trials are ongoing to evaluate the potential of the combination therapy of venetoclax in advanced solid tumors, in particular in combination with ABBV-181, an anti-PD1 monoclonal antibody (NCT03000257), with ABBV-621, a second-generation TRAIL-receptor agonist (NCT03082209), and with idasanutlin, a small molecule designed to bind to murine double minute 2 (MDM2), for pediatric and young adult patients with neuroblastoma or other malignancies (NCT04029688). Other BH3 mimetics targeting Bcl-2 such as S55746 [ 134 ] and its prodrug S65487 are under evaluation in clinical trials for the treatment of CLL, NHL and MM patients (NCT03755154). Active clinical trials with specific BH3 mimetics are reported in Table 1 . Several preclinical studies also investigated the efficacy of venetoclax in combination therapy for solid tumors. Studies conducted in melanoma models demonstrated the ability of venetoclax to empower the efficacy of mitochondrial matrix chaperone inhibitor [ 135 ]. Studies performed in estrogen-positive breast cancer cell lines, patient-derived organoid and patient-derived xenograft models evidenced the efficacy of venetoclx in combination with both fulvestrant/palbociclib and anti-PD1 therapy [ 136 ], while results on merkel cell carcinoma indicated the combination of venetoclax with DNA damage induction as a possible novel therapeutic strategy for this skin cancer [ 137 ]. Resistance to venetoclax in NHL cell lines has been reported to be overcome by Mcl-1 selective inhibitor A-1208746 or Bcl-xL selective inhibitor A-1155463 in combination with venetoclax [ 138 ]. Venetoclax and navitoclax synergized with doxorubicin or dinaciclib, an inhibitor of cyclin-dependent kinases, providing effective therapeutic strategies in SCLC [ 84 ]. 3.2.5. Bcl-xL Specific Inhibition Experimental evidence indicates that overexpression of Bcl-xL could be associated with resistance to venetoclax and chemotherapic agents [ 138 , 139 , 140 ]. This consideration prompted the development of specific Bcl-xL inhibitors. WEHI-539 was the first molecule to specifically target Bcl-xL [ 141 ]. It was found to enhance apoptosis in combination with doxorubicin in osteosarcoma cells expressing high level of Bcl-xL protein [ 142 ]. However, the observed in vivo toxicity limited its applicability in clinical trials [ 141 ]. Structure-based design optimization of WEHI-539 led to the development and characterization at preclinical level of other selective inhibitors of Bcl-xL, such as A-1155463, showing in vivo antitumor activity in a xenograft model of SCLC, and A-1331852 increasing the sensitivity of rhabdomyosarcoma cells to several conventional chemotherapeutic agents without apparent toxicity [ 139 , 143 , 144 ]. To date, no specific Bcl-xL inhibitor has passed to clinical evaluation. 3.2.6. Mcl-1 Specific Inhibition In recent years an increasing interest in developing a Mcl-1-specific inhibitor is arising, especially for hematological tumors. Rationale and progress in targeting Mcl-1 in hematologic malignancies have been recently reviewed [ 145 ]. UMI-77 was the first designed molecule with selected affinity for Mcl-1 [ 146 ], showing in vivo tumor growth inhibition in models of pancreatic cancer. Subsequent developed molecules were A-1210477, showing cell killing activity as single agents and in combination with navitoclax in leukemia cells [ 147 ], and inducing apoptosis in breast cancer [ 148 ], as well as compounds 4 and 5, showing apoptosis activity in primary MM and AML patient-derived cells [ 149 ]. S63845 showed high level of apoptotic induction in a wide range of hematopoietic malignancies, breast and NSCLC cell lines and with an acceptable safety margin as a single agent in in vivo experiments in several cancer models [ 86 ]. Several preclinical studies suggested the promising application of Mcl-1 inhibitors in combinatorial therapy: combinations of S63845 and AMG-176 (and the related compound AM8621) with inhibitors of fibroblast growth factor receptor (FGFR), MEK or BRAF showed to efficiently reduce in vitro cell proliferation and in vivo tumor growth of NSCLC [ 86 , 150 ], lung squamous cell carcinoma [ 151 ] and glioblastoma [ 152 ] models, while combinations of S63845 with chemotherapy or HER2-targeted therapies demonstrated to efficiently inhibit the growth of triple-, as well as HER-2-positive breast cancer [ 86 , 153 ]. The efficacy of combination of S63845 with selective inhibitors, such as ABT-199 or A-1331852, has been also reported in preclinical cervical cancer models [ 154 ] and pediatric solid tumors [ 155 ], while S63845 in combination with inhibitors of the bromodomain and extra-terminal proteins showed efficacy in metastatic melanoma [ 156 ]. The first Mcl-1 inhibitor to progress in Phase I trial was AMG-176, evaluated in R/R MM and R/R AML (NCT02675452). Unfortunately, some clinical trials using Mcl-1 inhibitors, such as AMG-397, have been suspended for cardiac toxicity (NCT03465540). This toxicity can be due to the relevant role of Mcl-1 in cardiac homeostasis in adult murine models, loss of Mcl-1 causing alterations in cardiomyocytes and lethal cardiomyopathy [ 157 , 158 ]. AZD5991 and S64315/MIK665 at present are under evaluation in clinical trials as a single agent, Phase I, or in combination with venetoclax, Phase II, in R/R hematologic malignancies (NCT03218683, NCT02979366, NCT02992483, NCT03672695). Clinical trials for evaluation of Mcl-1 BH3-specific inhibitors are reported in Table 1 . Recently, VU661013, a new Mcl-1-specific inhibitor, has been reported to rescue venetoclax resistance in AML [ 159 ] and inhibit cell survival in estrogen receptor-positive breast cancer when used in combination with navitoclax [ 160 ]. An alternative strategy to the use of specific Mcl-1 inhibitors is to target Mcl-1 indirectly. Since Mcl-1 expression is regulated by the transcriptional activator Cyclin-dependent kinase 9 (CDK9), the use of specific CDK9 inhibitors is a promising approach for the treatment of tumors expressing high levels of Mcl-1 protein [ 161 ]. The highly selective CDK9 inhibitor, AZD4573, induced apoptosis and subsequent cell death in hematologic cancer models in vitro and favored tumor regression in tumor xenografts in vivo, through the indirect inhibition of Mcl-1 [ 161 ]. AZD4573 is currently under evaluation in a Phase I clinical trial for patients with hematologic malignancies (NCT03263637). 3.3. BH3 Peptides In addition to molecules resembling the BH3 domain, the use of BH3 peptides has also been evaluated as a possible strategy to inhibit Bcl-2 anti-apoptotic members. Biochemical studies based on computational mutagenesis and docking approaches led to the development of BINDI proteins, formed by a BH3-like central helix with two flanking regions which form additional interactions that are specific for the different anti-apoptotic Bcl-2 proteins. This strategy resulted in proteins able to bind anti-apoptotic Bcl-2 proteins with increased affinity and specificity, and demonstrated that the designed inhibitors were able to induce apoptosis in cancer cells in vitro by engaging the BH3-binding grooves of specific pro-survival proteins [ 162 ]. A very recent and elegant paper explored the possibility of de novo designing switchable protein systems to modulate binding among proteins, and demonstrated the possibility to modulate the binding of Bcl-2 to Bim, thus opening the prospective of using this system to regulate the function of Bcl-2 family members [ 163 ]. A series of BH3 sensitizer peptides that bind Bcl-xL with sub-nanomolar affinity and selectivity up to 1000-fold over each of the competing pro-survival proteins, have been tested in vitro in a panel of cancer cell lines, showing reduced proliferation in cells expressing high level of Bcl-xL protein [ 164 ]. 3.4. Molecules Promoting Protein Conformational Change Another interesting approach to inhibit Bcl-2 functions is to target the BH4 domain. The BH4 domain of Bcl-2 binds to the inositol 1,4,5-trisphosphate receptor (IP3R), preventing Ca2+ signals that mediate cell death. In many cancers the high level of Bcl-2 expression inhibits IP3R-mediated Ca2+ elevation, thus preventing apoptosis [ 165 ]. Moreover, the BH4 domain has been also reported to be involved in the so-called “non-canonical” Bcl-2-mediated functions, not including anti-apoptotic and pro-survival functions [ 6 ]. Thus, BH4 has become an interesting target for drug development [ 166 ]. Structural studies were employed to identify BDA-366, an allosteric Bcl-2 inhibitor able to bind the BH4 domain, inducing a conformational change in the protein responsible for the exposure of the BH3 domain, which converts Bcl-2 in a pro-apoptotic protein [ 167 ]. BDA-366 was found to inhibit both lung cancer [ 167 ] and myeloma growth in vitro and in vivo [ 168 ]. The Zhang group identified the Q221R222N223 motif, QRN, as a hidden conformational switch controlling ubiquitination of Mcl-1, and demonstrated the ability of compound 5, a dual-function Mcl-1 inhibitor, to favor Mcl-1 ubiquitination by promoting helical conformation of QRN, thus inducing both apoptosis and Mcl-1 degradation [ 169 ]. A new approach for disarming Mcl-1 in cancer identified an allosteric mechanism able to disrupt the binding activity of Mcl-1 to BH3 domain of pro-apoptotic proteins: allosteric Mcl-1 inhibitors specifically target Cysteine 286, inducing conformational changes and allosteric inhibition of BH3 domain interaction with Mcl-1 [ 170 ], or bind to Lysine 234 allowing specific increase in binding to Mcl-1 over other Bcl-2 family members [ 171 ]. 3.5. Bcl-2 Quadruplex Selective Approach Preclinical evidence also supports the Bcl-2 G-quadruplex (G4)-selective approach to treat cancer and to circumvent the limitations of Bcl-2 protein-based therapeutics [ 172 ]. In the proximity of the P1 promoter (5′), three G4 and one i-motif have been reported to regulate Bcl-2 transcription [ 173 ]. Furthermore, the Bcl-2 5′ untranslated region containing an RNA G4-forming motif has been found to modulate Bcl-2 protein expression [ 174 ]. The in-depth characterization of these structures provided information for designing small molecules targeting G4 and regulating the expression of Bcl-2. The desirable molecules should show high affinity to Bcl-2 G4 and low affinity to duplex or other G4. Although a high number of G4, mainly identified by computational methods or structure-based drug design, show good binding affinity to the Bcl-2 quadruplex, they could not achieve good drug candidature for their failure to discriminate different G4, such as telomeric and other oncogenic G4. At present only a few compounds targeting G4 structures have been successfully evaluated in cellular and in vivo models. Quindoline, perylene and coronenen derivatives have been reported to downregulate Bcl-2 transcription and promoter activity and to induce apoptosis in cancer models but with a promiscuous mechanism of action affecting also other biological targets, such as telomeric and other oncogenic G4 [ 175 , 176 ]. Some organometallic complexes have been found to be more selective to Bcl-2 than to telomeric quadruplex, to have poor affinity for duplex DNA and to exhibit in vitro and in vivo antitumoral activity against cancer models from different histotypes [ 177 ]. Very recently, drug-like imidazo [2,1-i] purine derivatives have been identified by a bioinspired design and have been reported to show antitumoral activity through their effect on Bcl-2/c-myc gene promoter G4 [ 178 ]. Furthermore, furopyridazinone-based molecules have been found to target the Bcl-2 gene promoter G4 with good selectivity and induce cytotoxic effect in T-lymphoblastoid cells [ 179 ]. Ligands able to target and stabilize G4 structures both in the Bcl-2 gene and in its RNA transcript have been also reported [ 180 ]. Due to the promiscuity to other molecular targets, to the poor bioavailability and to the conformational rigidity, the clinical pharmacology of G4-stabilizing molecules is still at the beginning. 4. Vaccination Using Anti-Apoptotic Protein-Derived Peptides The induction of active immunity against tumor-associated antigens may be a promising approach to prevent cancer relapse, and thus there is a need to identify tumor-associated antigens for the development of cancer vaccination. In this context, spontaneous T cell responses against anti-apoptotic protein-derived peptides in patients suffering from cancers of different origin have been reported [ 181 ]. In particular, in vitro T cell responses against a peptide derived from Bcl-xL was observed in cancer patients but not in healthy controls, and the subpopulation of T cells specific for the Bcl-xL peptide was cytotoxic against HLA-matched cancer cells of different histotypes [ 181 ]. Two murine tumor-associated epitopes derived from mouse Bcl-xL have been reported to induce CD8+ T cell production of interferon-γ in mice, providing a preclinical model for cancer vaccination [ 182 ]. These preclinical studies supported the passage to Phase I trial evaluation of therapeutic vaccination with peptides from Bcl-2, Bcl-xL and Mcl-1 in patients with relapse MM (NCT01272466). In this study, vaccines were given in combination to treatment with bortezomib [ 183 ]. This vaccination was well tolerated and the signs of toxicity were all attributed to bortezomib. Moreover, the safety, toxicity and immunological effect of vaccine Bcl-xl_42-CAF09b, composed of Bcl-xl_42, a peptide fragment of the full protein and the adjuvant CAF09b, able to improve the activation of the immune system, are under evaluation in patients with hormone-sensitive prostate cancer and lymph node metastases in a Phase I trial (NCT03412786). 5. Pro-Apoptotic Bcl-2 Family Protein Activations Several structural studies have helped the understanding of determinant for regulation and activation of pro-apoptotic proteins [ 184 , 185 ]. These findings have been used to design peptides specifically targeting and activating the pro-apoptotic function of Bax, Bak and Bim, in order to promote cell death [ 186 ]. The use of a hydrocarbon-stapled Bim BH3 peptide (Bim SAHBA) was shown to overcome both Bcl-2 and Mcl-1 apoptotic resistance in B-cell lymphoma cell lines [ 187 ]. In another study, the potent BH3 α-helical domain of Bim has been incorporated into peptide amphiphile nanostructures to facilitate cellular uptake, showing specificity of binding to Bcl-2 anti-apoptotic proteins and inducing cell death in mouse embryonic fibroblasts [ 188 ]. Computational methods have been applied in order to design BH3 peptides derived from Puma and Bmf showing high binding affinity for A1/Bfl-1 [ 189 ]. Free energy binding studies of complexes formed by Bak and BH3 peptides have been employed to find the main residues responsible for inhibition of activation of Bak, which are useful in designing novel small molecule mimics of BH3 able to promote the mitochondrial pore formation mediated by Bak [ 190 ]. Although Bcl-2 is a recognized anti-apoptotic protein, in some conditions Bcl-2 associates with the orphan nuclear hormone receptors Nur77 and Nor-1, converting Bcl-2 into a pro-apoptotic molecule [ 191 ]. NuBCP-9, a Nur77-derived peptide, induces a conformational change, exposing the Bcl-2 BH3 domain, finally inhibiting tumor growth in vitro and in vivo [ 192 ]. 6. Conclusions The involvement of apoptosis has been long studied for its response to conventional chemotherapy, but its relevance is also clear in response to more innovative treatment strategies. The family of Bcl-2 proteins has long been known to play a pivotal role in the regulation of apoptosis. In the last decades, a huge amount of evidence has demonstrated that cancers from different origin, especially hematological malignancies, strictly depend on anti-apoptotic members for proliferation, survival and response to therapy. In this view, intense studies have been performed in order to identify Bcl-2 inhibitors to be used for cancer therapy, and cell death discoveries have been translated into the identification of novel therapies using Bcl-2 family inhibitors. Starting from the clinical use of antisense oligonucleotides directed against Bcl-2, and passing through BH3 mimetics that showed severe on-target toxicity, recent FDA approval of the BH3 mimetic venetoclax corroborated the clinical relevance of using Bcl-2 anti-apoptotic members as therapeutic targets, not only for hematologic malignancies but also for breast carcinoma. Numerous clinical trials are ongoing to evaluate the activity on solid tumors of specific or dual inhibitors as single agents or in combination therapy. We hope positive results can offer a way for these therapeutic strategies to be used for treatment of a large amount of solid malignancies. A huge volume of preclinical studies have accumulated evidence in support of the role played by anti-apoptotic proteins in the progression of solid tumors. Thus, the use of Bcl-2 protein-targeting drugs as single agents or in combination with current standard-of-care therapies could represent a concrete opportunity to overcome therapy-resistant/recurrent solid tumors and to increase the disease-free survival of cancer patients. Further studies are required to confirm the clinical potential of Bcl-2 inhibitors as single and combinatorial agents for the therapy of chemotherapy-sensitive and resistant cancer. It is likely that a number of malignant diseases other than hematologic ones in the near future will be successfully targeted with anti-apoptotic Bcl-2 family members after careful patient selection, to improve treatment responses and patient survival. Supplementary Materials The following are available online at https://www.mdpi.com/2073-4409/9/5/1287/s1 , Table S1: List of completed clinical trials for the evaluation of oblimersen; Table S2: List of completed clinical trials for the evaluation of obatoclax; Table S3: List of completed clinical trials for the evaluation of AT-101. Author Contributions S.D. writing—Original draft preparation; D.D.B. writing—Review and editing. All authors have read and agreed to the published version of the manuscript. Funding The manuscript is supported by Grants from Italian Association for Cancer Research (DDB, IG 18560). Acknowledgments We thank Pierre Drap, CNRS, L.I.S. umr 7020, Aix-Marseille University, for technical support in Figure 2 . This work is dedicated to our splendid colleague Marianna Desideri, who passed away, for having dedicated her scientific life with passion and tenacity to the study of the role of Bcl-2 protein in cancer. 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[ Google Scholar ] [ CrossRef ] Banta, K.L.; Wang, X.; Das, P.; Winoto, A. B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2’s apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors. J. Biol. Chem. 2018 , 293 , 4724–4734. [ Google Scholar ] [ CrossRef ] [ PubMed ][ Green Version ] Kolluri, S.K.; Zhu, X.; Zhou, X.; Lin, B.; Chen, Y.; Sun, K.; Tian, X.; Town, J.; Cao, X.; Lin, F.; et al. A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell 2008 , 14 , 285–298. [ Google Scholar ] [ CrossRef ] [ PubMed ][ Green Version ] Figure 1. Expression of Bcl-2 in cancer. Bar charts showing the expression in different tumor histotypes of Bcl-2 mRNA, reported as fragments per kilobase of exon model per million reads mapped (FPKM), and protein, detected by immunohistochemistry and reported as percentages of positive patient samples. Data are from The Human Protein Atlas database ( https://www.proteinatlas.org/ ). Figure 1. Expression of Bcl-2 in cancer. Bar charts showing the expression in different tumor histotypes of Bcl-2 mRNA, reported as fragments per kilobase of exon model per million reads mapped (FPKM), and protein, detected by immunohistochemistry and reported as percentages of positive patient samples. Data are from The Human Protein Atlas database ( https://www.proteinatlas.org/ ). Figure 2. Expression of Bcl-xL in cancer. Bar charts showing the expression in different tumor histotypes of Bcl-xL mRNA, reported as fragments per kilobase of exon model per million reads mapped (FPKM), and protein, detected by immunohistochemistry and reported as percentages of positive patient samples. Data are from The Human Protein Atlas database ( https://www.proteinatlas.org/ ). Figure 2. Expression of Bcl-xL in cancer. Bar charts showing the expression in different tumor histotypes of Bcl-xL mRNA, reported as fragments per kilobase of exon model per million reads mapped (FPKM), and protein, detected by immunohistochemistry and reported as percentages of positive patient samples. Data are from The Human Protein Atlas database ( https://www.proteinatlas.org/ ). Figure 3. Expression of Mcl-1 in cancer. Bar charts showing the expression in different tumor histotypes of Mcl-1 mRNA, reported as fragments per kilobase of exon model per million reads mapped (FPKM), and protein, detected by immunohistochemistry and reported as percentages of positive patient samples. Data are from The Human Protein Atlas database ( https://www.proteinatlas.org/ ). Figure 3. Expression of Mcl-1 in cancer. Bar charts showing the expression in different tumor histotypes of Mcl-1 mRNA, reported as fragments per kilobase of exon model per million reads mapped (FPKM), and protein, detected by immunohistochemistry and reported as percentages of positive patient samples. Data are from The Human Protein Atlas database ( https://www.proteinatlas.org/ ). Figure 4. Bubble chart showing the number of published papers in the last 30 years regarding Bcl-2, Bcl-xL, Mcl-1, Bcl-w, Bcl-B and A1/Bfl-1 anti-apoptotic proteins associated with apoptosis, cancer, therapy or resistance. Figure 4. Bubble chart showing the number of published papers in the last 30 years regarding Bcl-2, Bcl-xL, Mcl-1, Bcl-w, Bcl-B and A1/Bfl-1 anti-apoptotic proteins associated with apoptosis, cancer, therapy or resistance. Figure 5. Schematic representation of BH3 mimetics. For each BH3 mimetic the corresponding Bcl-2 anti-apoptotic protein targets are indicated by lines categorizing BH3 mimetics according to their specificity (multitargets, dual or specific inhibitors). * Sabutoclax is not reported to inhibit Bcl-w. Table 1. Active clinical trials with BH3 mimetics (update 7 April 2020). Table 1. Active clinical trials with BH3 mimetics (update 7 April 2020). Inhibitor Specificity Clinical Trial Identifier Tumor Histotype Phase Combination with Navitoclax Bcl-2/Bcl-xL/ Bcl-w NCT04041050 myelo- proliferative neoplasm I Ruxolitinib or single agent NCT03222609 myelofibrosis II Ruxolitinib or single agent NCT00788684 lymphoid cancers I Ruxolitinib NCT02520778 advanced or metastatic non-small lung cancer I Osimertinib NCT02143401 relapsed or refractory solid tumors I Sorafenib NCT02079740 advanced or metastatic solid tumors I/II Trametinib NCT01989585 BRAF mutant melanoma I/II Dabrafenib/ Trametinib APG-1252 Bcl-2/Bcl-xL NCT03080311 small cell lung cancer or other solid tumors I single agent NCT04210037 relapsed/ refractory small cell lung cancer I/II Paclitaxel AZD0466 Bcl-2/Bcl-xL NCT04214093 hematologic or solid tumors I single agent Venetoclax Bcl-2 NCT03000257 advanced solid tumors I ABBV-181 NCT03082209 previously treated solid tumors and hematologic malignancies I ABBV-621 NCT03181126 relapsed/ refractory acute lymphoblastic leukemia and relapsed/ refractory lymphoblastic lymphoma I Navitoclax NCT04029688 relapsed/refractory acute leukemias or solid tumors I/II Idasanutlin S65487 Bcl-2 NCT03755154 acute myeloid leukemia, non-Hodgkin lymphoma or multiple myeloma I single agent AMG-176 Mcl-1 NCT02675452 relapsed or refractory multiple myeloma and subjects with relapsed or refractory acute myeloid leukemia I single agent AZD5991 Mcl-1 NCT03218683 relapsed or refractory hematologic malignancies II Venetoclax S64315/ MIK665 Mcl-1 NCT02979366 acute myeloid leukemia or myelodysplastic syndrome I single agent NCT02992483 refractory or relapsed lymphoma or multiple myeloma I single agent NCT03672695 acute myeloid leukemia I Venetoclax
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Acute calcium pyrophosphate deposition arthropathy | Request PDF Request PDF | Acute calcium pyrophosphate deposition arthropathy | Acute calcium pyrophosphate deposition (CPPD) arthropathy, also called pseudogout, is common, and becomes more prevalent as patients age. The... | Find, read and cite all the research you need on ResearchGate Article Acute calcium pyrophosphate deposition arthropathy June 2016 JAAPA: official journal of the American Academy of Physician Assistants29(6):1-3 DOI: 10.1097/01.JAA.0000483101.96888.5c Authors: <here is a image f2f62089ad6ff61c-d19572ff1996375a> Thomas Rosen Thomas Rosen This person is not on ResearchGate, or hasn't claimed this research yet. <here is a image d54ebd79faedcbb1-6cf86d359f403e7d> Janet Furman Rush University Medical Center Abstract Acute calcium pyrophosphate deposition (CPPD) arthropathy, also called pseudogout, is common, and becomes more prevalent as patients age. The presenting symptoms are similar to both gout and septic arthritis but may be treated differently. This article describes a typical patient presentation and management from an emergency medicine and orthopedic surgery standpoint. <here is a image 175d1bd4b7439d95-754927124da715c1> ... 1,8 Common signs include erythema, warmth, and swelling of the affected joint, with a clinical presentation similar to gout or septic arthritis. 9 Patients often present with fevers, chills, and constitutional symptoms lasting weeks to months. 1 The knee (hyaline cartilage and menisci) is by far the most common site, followed by the wrist (triangular fibrocartilage) and pelvis (symphysis pubis). 5 In many patients chondrocalcinosis is asymptomatic and an incidental finding on X-ray examination, but others present with an acute inflammatory arthritis (pseudogout) or a chronic inflammatory arthropathy superimposed on a background of osteoarthritis, especially at the knee, associated with joint damage and functional limitation. ... Rare case of pseudogout in the scapular region Article Full-text available Apr 2019 Zenina Reuben Andrews <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Mohanapriya Thyagarajan <here is a image 1937ee36a50dd27a-fa33d150fae83bfe> Balaji Singh - Krishna Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) also referred to as pseudogout is an inflammatory arthritis produced by the deposition of calcium pyrophosphate crystals in the synovium and periarticular soft tissues. This report documents a case of a 41 year old female who presented with a painful swelling in the back. MRI revealed a complex swelling with lobulation of size 7.4×7.4×7 cm in the posterolateral aspect of chest wall just superficial to the ribcage. A surgical excision biopsy of the swelling was done and patient improved symptomatically. Serum uric acid levels were measured and found to be within limits. ... 26 Patients with pseudogout often present with fevers, chills, and constitutional symptoms lasting weeks to months, and the clinical presentation can be similar to gout or septic arthritis. 23, 25 The disease typically affects larger joints with cardinal signs of inflammation including warmth, tenderness, erythema, and swelling. 5 However, the spine can also be affected. ... Pseudogout of the cervical and thoracic spine mimicking infection after lumbar fusion: Case report Article May 2017 J NEUROSURG-SPINE Kelly J. Bridges Carli Bullis Ajay Wanchu Khoi D. Than Pseudogout is a form of acute calcium pyrophosphate deposition (CPPD) disease that typically afflicts the elderly. CPPD commonly involves larger joints, such as the knees, wrists, shoulders, and hips, and has been known to involve the spine. The authors report the case of a 66-year-old woman with a recent history of lumbar laminectomy and fusion who presented 5 weeks postprocedure with a clinical and radiographic picture consistent with multilevel skip lesions involving the cervical and thoracic spine, thoracic discitis, and epidural abscess. Serial blood cultures and repeat biopsy samples were sterile. Subsequent wrist and ankle erythema, pain, and swelling led to synovial fluid analysis, and pseudogout was diagnosed. She was treated with an interleukin-1 inhibitor with immediate symptom relief. To the authors’ knowledge, this is only the second report of spinal pseudogout presenting with a clinical and radiographic picture consistent with discitis and epidural abscess. This report is the first to report skip lesions of pseudogout occurring throughout the spine that are uniquely remote from a recent lumbar surgery. Treatment and management of pseudogout: Insights for the clinician Article Full-text available Apr 2012 Ther Adv Musculoskelet Dis Pseudogout and the associated calcium pyrophosphate dihydrate (CPPD)- crystal-related arthropathies are common conditions that present particular management problems in clinical practice as they often affect older patients with multiple medical comorbidities. The epidemiology, metabolic and endocrine disease associations, and routine investigations used in the diagnostic workup are briefly reviewed. Current treatment approaches that are mainly directed at relieving the symptoms of joint inflammation are outlined. Unlike gout, there are no agents available that have been shown to decrease crystal load in CPPD-related joint disease. Recent novel insights into the pathogenesis of crystal-induced joint inflammation and subsequent joint degeneration are also discussed. The potential of colchicine as a prophylactic agent in managing recurrent attacks and the likely mechanisms of its effects on the NACHT, LRR and PYD domains-containing protein 3 (NALP-3) inflammasome of the innate immune system are highlighted. The use of agents that directly target the inflammasome, in particular drugs which inhibit the interleukin 1 pathway, in the treatment of severe, refractory pseudogout is also discussed. Finally, there is particular emphasis on the likely pathogenic role of CPPD crystal deposition in degenerative joint disease and the use of targeted anticrystal therapies as potential disease-modifying drugs. Imaging of Calcium Pyrophosphate Deposition Disease Article Mar 2015 Curr Rheumatol Rep Calcium pyrophosphate deposition disease (CPPD) is a common and clinically heterogeneous form of arthritis caused by the deposition of calcium pyrophosphate (CPP) crystals in articular tissues. The diagnosis of CPPD is supported by the presence of radiographic chondrocalcinosis; yet, conventional radiography detects only about 40 % of clinically important CPPD. Here, we critically review the recent literature on imaging in CPPD. New studies inform our use of conventional radiographic screening methodologies for CPPD and provide additional evidence for the utility of diagnostic ultrasound. Recent work also highlights the polyarticular nature of CPPD, its association with tissue damage, and the high prevalence of tendon involvement. While dual energy CT and diffraction-enhanced synchrotron imaging remain research tools, they present potential avenues for improved visualization of CPP deposits. Advances in imaging in CPPD will increase diagnostic accuracy and eventually result in better management of this common form of arthritis. Calcium pyrophosphate deposition Article Apr 2014 BRIT J HOSP MED Epidemiology of Calcium Pyrophosphate Crystal Arthritis and Basic Calcium Phosphate Crystal Arthropathy Article May 2014
https://www.researchgate.net/publication/303552822_Acute_calcium_pyrophosphate_deposition_arthropathy
Coatings | Free Full-Text | Study of Tribotechnical Properties of Multilayer Nanostructured Coatings and Contact Processes during Milling of Titanium Alloys The paper presents the results of theoretical and experimental research on tribotechnical characteristics: tool wear on the back surface, tool durability period, critical length of the cutting path before blunting, adhesion component of the friction coefficient, contact processes, temperature, and force dependences for the application of innovative nanostructured multilayer composite coatings on a tool for milling of titanium alloys. The proposed thermodynamic model of cutting tool wear allows us to determine the ways by which cutting tool wear intensity decreases and the conditions of increase in cutting tool wear resistance with wear-resistant coatings. A substantial increase in wear resistance of end mills when processing titanium alloys with the use of innovative multilayer nanostructured coatings is established, in particular an improvement of an average of 1.5& ndash;2 times. These positive results are related to a significant decrease in temperature& ndash;force loading in the cutting zone, a decrease in the friction coefficient (adhesion component), and the phenomenon of adaptation (self-organization) of friction surfaces during cutting by tools with wear-resistant coatings, contributing to the formation of films of various compounds with shielding, protective, and lubricating properties. Study of Tribotechnical Properties of Multilayer Nanostructured Coatings and Contact Processes during Milling of Titanium Alloys by Mars Sharifullovich Migranov * , Semen Romanovich Shehtman , Nadezhda Aleksandrovna Sukhova , Artem Petrovich Mitrofanov , Andrey Sergeevich Gusev , Arthur Marsovich Migranov and Denis Sergeyevich Repin Department of High-Efficiency Processing Technology, Institute of Production Technology and Engineering, Moscow State Technological University STANKIN, 127055 Moscow, Russia Author to whom correspondence should be addressed. Coatings 2023 , 13 (1), 171; https://doi.org/10.3390/coatings13010171 Received: 28 December 2022 / Revised: 9 January 2023 / Accepted: 10 January 2023 / Published: 12 January 2023 (This article belongs to the Special Issue Technologies of Coatings and Surface Hardening for Tool Industry II ) The paper presents the results of theoretical and experimental research on tribotechnical characteristics: tool wear on the back surface, tool durability period, critical length of the cutting path before blunting, adhesion component of the friction coefficient, contact processes, temperature, and force dependences for the application of innovative nanostructured multilayer composite coatings on a tool for milling of titanium alloys. The proposed thermodynamic model of cutting tool wear allows us to determine the ways by which cutting tool wear intensity decreases and the conditions of increase in cutting tool wear resistance with wear-resistant coatings. A substantial increase in wear resistance of end mills when processing titanium alloys with the use of innovative multilayer nanostructured coatings is established, in particular an improvement of an average of 1.5–2 times. These positive results are related to a significant decrease in temperature–force loading in the cutting zone, a decrease in the friction coefficient (adhesion component), and the phenomenon of adaptation (self-organization) of friction surfaces during cutting by tools with wear-resistant coatings, contributing to the formation of films of various compounds with shielding, protective, and lubricating properties. Keywords: counter milling ; nanostructured composite multilayer coatings ; titanium alloys ; wear resistance ; tool durability period ; cutting path length ; adhesion component of friction coefficient ; temperature ; cutting forces 1. Introduction The rapid growth of modern machine-building production places increased demands on machining. High-productivity mechatronic systems require increasing the reliability and serviceability of cutting tools by, first, using various methods to improve the cutting properties of tools (hardening technologies and the use of coolant and wear-resistant coatings and their combinations); second, developing modern methods to evaluate the tribotechnical properties of cutting tools; and, third, making scientifically justified choices of cutting modes, taking into account the characteristics of contact processes (temperature and force of cutting). Regarding the problem of improving the serviceability of cutting tools and technological reliability of multitool and multitransition machining on machine tools with control systems, the issues of wear, fracture, strength, and stress–strain state of cutting tools and the study of thermal and contact phenomena are topics of the fundamental research of many scientists [ 1 , 2 , 3 , 4 , 5 ]. The results of these works allowed the study of the physical mechanisms of cutting tool wear in a wide range of changing elements of the cutting regime and solutions for optimization and control problems of the cutting process and played a major role in the formation of modern concepts in the theory of material cutting. At the same time, the use of mechatronic systems equipped with high-speed numerical control (NC) and adaptive control (AdC) [ 6 , 7 , 8 ] machines solves extremely important problems of increasing machining productivity and automation of individual and small-scale production widespread in modern mechanical engineering, but metal-cutting equipment of turning and milling groups has a considerable cost, which has led to high requirements for the scientific validity of cutting modes. In the manufacture of parts of heavily loaded high-temperature tribocouplings, more and more are made of innovative materials: with unique physical and mechanical properties and, therefore, with low machinability by cutting; in terms of their geometric shape, they mainly represent large-sized complex shaped bodies: bodies, disks, shafts, rotors, flanges, etc. Their work takes place in harsh conditions of simultaneous and long exposure to high temperatures and specific force loads, with high requirements in terms of both accuracy and quality of surface processing. The small dimensional tolerances are due not only to the requirements of interchangeability of the mating surfaces but also to the specific conditions of “high accuracy”, due to which even free dimensions must have small tolerances. The machining of the parts listed above constitutes a significant share of milling operations. The technological problems encountered in the production of each of the above varieties of parts are somewhat different. For example, end milling of a long-sized workpiece with a relatively small thickness is characterized by the large suppleness of the part, so special devices must be developed to create constant stiffness across the entire blade. When machining hollow shafts and rotors made of titanium alloys, it can be difficult to mill slotted and toothed parts due to their long length. However, there is also a general problem of machining such parts associated with the low wear resistance of metal-cutting tools [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Nanostructured coatings are one of the typical small-sized objects, which are intensively studied due to the interest in identifying the features of the nanocrystalline state, characterized usually by sizes less than 100 nm [ 14 , 15 , 16 ]. As was already noted, metal-cutting tools, in most cases and for a few reasons, work in conditions of intermittent cutting and are exposed to alternating thermomechanical influence, leading to their rather intensive destruction in the form of chipping and active cracking. Changes in thermal–physical, physical–mechanical, and crystallochemical characteristics influence tool serviceability. It is known [ 17 , 18 ] that the modification of cutting tool properties by applying multifunctional nanostructured coatings on its working surfaces is one of the most effective ways to improve its reliability. The currently available equipment and technological processes allow the synthesis of multilayer coatings with multicomponent composite architecture, with a nanoscale thickness of nanolayers on modern and highly efficient facilities by various methods, including PVD with magnetic arc filtration, magnetron, and multifunctional high-energy, to modify the surfaces of metal-cutting tools. At the same time, many studies [ 18 , 19 , 20 ] have established unique properties that are unique only to modern multifunctional nanostructured coatings. Nano-objects are interesting, on the one hand, as metal-like compounds and, on the other hand, as typical brittle phases, not to mention the numerous applications of materials based on embedding phases. In this regard, data on the structure and properties of these compounds in the nanocrystalline state appear to be important for both theoretical materials science and applications. The specific properties of nanostructured coatings are largely due to the peculiarities of their structure: the high-volume fraction of interfaces, the strong binding energy of adjacent phases, the absence of dislocations within nanocrystallites, the implementation of deformation by grain boundary slip, the presence of intergranular amorphous interlayers, and the change in the mutual solubility of components in the embedding phases. All these features allow the achievement of record values of physical, chemical, mechanical, and tribological properties of the material during the transition to the nanostructured state [ 17 , 18 ]. According to research [ 21 , 22 ], control of the technological process of the formation of nanostructured coatings allows the reception of compositions with variable properties depending on the percentage ratio of components. The hardness, friction coefficient, surface roughness, and coating color change. All this makes it possible to optimize the coating properties for a specific task. Applications include cutting, shaping, stamping, and other tools. For example, for TiZrN, high hardness, thermodynamic stability, and the strength of connection are caused by the high similarity of structures and the close sizes of atoms providing the presence of significant areas of mutual solubility of atoms Ti and alloying component Zr in corresponding nitrides. The maximum microhardness of coating TiZrN of 32.2 GPa is observed at the content of 6%–10% Zr, which exceeds the value of Hµ for coating TiN of 22%. The covering (Ti-Zr)CN on the basis of carbonitrides Ti and Zr, the microhardness of which corresponds to 64 GPa, is relative. In research [ 13 , 14 , 15 ], the extreme character of change in the intensity of wear of the cutting tool depending on the structure of the nanostructured coating is established. During the processing of workpieces from steels 12 × 18H10T, the minimum intensity of wear was observed at plates from alloy BK6 with TiZrN coating at a content of 8%–16% Zr. It is established that the minimum wear rate of the plates with carbonitride coating (Ti-Zr)CN corresponds to the same content of the alloying component as that of the plates with nitride-based coating. The minimum wear is observed at the content of acetylene of 25%–35% and 20%–25% when processing workpieces made of 12X18H10T steel. Studies of the machining process and the thermal and stress state of the cutting tool wedge have established that the coatings TiZrN and (Ti-Zr)CN increase the number of cycles before all longitudinal cracks escape to the back surface compared to the cutting tool with conventional coating by five times, and for nanostructured coatings TiZrN and (Ti-Zr)CN, by 8 and 6.25 times, respectively [ 13 ]. Thus, it can be concluded that nanostructured coatings allow an increase in the serviceability of cutting tools due to management of the parameters of coating structure, directionally controlled, which can significantly change coating properties; provide high crack resistance, strength properties, and a high level of compressive residual stresses restraining processes of the formation and development of cracks; and provide a low level of contact and thermal loads, minimizing processes of coating destruction. Proceeding from the above statements, the purpose of this work is to increase the efficiency of milling of titanium alloys by investigating tribotechnical properties and developing modern innovative wear-resistant coatings based on thermodynamic analysis of contact processes. The set goal of the work is achieved by describing the thermodynamic model of cutting tool wear, considering the influence of temperature, force parameters, and contact processes during blade cutting by cutting tools with nanostructured multilayer wear-resistant coatings; developing experimental research methods (wear resistance, temperature and force, adhesion, metal science, and others) and conducting them; and analyzing the obtained results. 2. Theoretical and Experimental Background Metal cutting, by its physical nature, is a complex process [ 12 , 13 , 14 , 15 ]; high pressures (up to 2000 MPa and more), high strain rates (up to 10 6 s −1 ), increased temperature (up to 1200–1500 K), etc., occur on the contact surfaces of the cutting tool with the machined material. This creates favorable conditions for the development of adhesion, mutual diffusion, oxidation, and hydrogen saturation of surfaces, changes in their structural and phase composition, and generation of electromotive force (EMF). These phenomena have a significant impact on the state and properties of the contact surfaces of the tool and the machined material. One of the main sources of heat and factors of the formation of near-surface layers during cutting is friction. Since it occurs at high temperatures under conditions of contact juvenility and with the presence of plastic deformations, the adhesion (molecular) component dominates in the adhesion processes [ 16 , 17 , 18 ]. The relative sliding of the contact surfaces of the tool and the workpiece is accompanied by a continuous process of adhesion spot formation and shearing. The tool surface is under the action of shear stresses, causing the material particles to shear away from the surface in places. Usually, such shearing is much greater on the softer material’s side, but studies using [ 19 , 20 , 21 , 22 ] electron microscopy show that there is always some transfer of particles from the harder material (tooling) to the softer material (machinable) at the same time. At the present time, when describing contact processes and the wear of a cutting tool, a complex power representation proposed in the works of Professors Y.G. Kabaldin, A.D. Makarov, V.N. Poduraev, S.S. Silin, N.V. Talantov, and other scientists is used [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. To describe the contact processes, friction, and wear of cutting tools with wear-resistant coatings, a dynamic process such as cutting is considered from the position of nonequilibrium thermodynamics, taking into account and specifying the components of energy balance of the process of interaction of the machining material and surfaces of the cutting tool. It is known [ 10 , 20 ] that the first law of thermodynamics for friction and wear processes can be written down by the equation: Wf = Q + ΔU (1) where Wf is the work of friction forces; Q is the amount of heat released under friction; and ΔU is the change in the internal energy of the friction contact zone. The change in internal energy can be represented as ΔU = ΔW mν + ΔW ph + ΔW Δd + ΔW Δf (2) where ΔW mν is energy spent on the separation of the wear particle, ΔW ph is energy spent on structural phase transformations, ΔW Δd is energy spent on plastic deformation, ΔW Δf is energy spent on the formation of rubbing surfaces, etc. Since, at present, there are no analytical dependences by which all components of expression (2) can be estimated, let us assume, at first approximation, that during friction, there will be dissipation of a part of internal energy at the expense of - Plastic deformation of a single microuneven (microcutting) as a result of shear by the average diameter of the contact spot; - The form modification of the surface layer of the wear material as a result of the formation of a wear fragment. Using the principles of nonequilibrium thermodynamics, an irreversible dynamic process such as wear can be most effectively described by means of dissipative functions (DF), Ψ ¯ i which are the rate of change ΔW i /dτ of energy spent on a process (for example, plastic deformation of the machined material), related to a unit of actual contact area A r . Ψ ¯ i = dW i d τ ⋅ 1 A r (3) According to the laws of nonequilibrium thermodynamics, to ensure the irreversibility of a process, it is necessary to have a generalized thermodynamic flux and force, i.e., supported by gradients of the state values of the thermodynamic system, preventing the inverse process and taken with the opposite sign. The DF of such a process is equal to the product of the generalized flux and force Ψ ¯ i = J i ( − Δ F i ) (4) where J i is generalized flux and Δ F i is generalized force. In the first approximation, the change in internal energy of the frictional thermodynamic system ΔU can be represented as the sum of energy spent on dispersion (wear) of the tool and energy of elastoplastic deformation of the processed material. Unfortunately, it is currently impossible to make a more precise quantitative assessment of the energies expended on structural phase transformations, etc., but an analysis of literature data allows us to qualitatively combine these moments and simplify and account for the other components. In this case, the DF balance equation can be represented as Ψ ¯ T = Ψ ¯ d + Ψ ¯ s (5) where is the DF of the friction process, ψ d is the DF of the shear plastic deformation process of the machined material by the mean diameter of the contact spot, and ψ s is the DF of dispersion and shape change of the surface layer of the wearable tool material. Using the methods of the theory of adaptation (self-organization) of nonequilibrium systems, physical kinetics, and force laws of the theory of strength and plasticity, the mechanochemistry of metals, thermal physics and cutting mechanics, and the components of the balance equation for the working conditions of tools with wear-resistant coatings are considered and specified. Based on the analysis of contact processes, the friction process DF is presented as a change in the specific work of external forces, referred to as the unit of contact area of the tool with chips and workpieces, considering the influence of the shape and radius of the cutting edge and the current value of cutting force: ¯ P z ( τ ) ⋅ f where P τ ) is the current value of cutting force; V i is the current value of cutting speed; l 1 and c are the contact lengths of the cutter with the chip and with the workpiece, respectively, on the front and back surfaces; b is the width of the cut layer; and f is the friction factor. The plastic deformation of the processed material is determined by the current θ(τ) and initial θ 0 values of the cutting temperature, the degree of plastic deformation ∆γ, the short-term yield strength σ T . д . and the shear modulus G д of the processed material, and the resonant frequency of self-oscillations in the contact zone f r : Ψ ¯ d = 10 − 4 θ ( τ ) ⋅ Δ γ ⋅ [ f r ⋅ . д . G д ⋅ θ ) exp 1 n (7) The DF of the form change of the tool material is determined based on the analysis of the form stability of the cutting edge, the model of damage accumulation in the contact layers of the tool, and the probabilistic nature of the wear particle separation set out in the works of Professor T.N. Loladze, as well as the specification of the wear scheme: Ψ ¯ s = J h ⋅ V ⋅ ( HV t HV m ) α ⋅ J h is wear intensity, V is cutting speed, HV t /HV m is the ratio of microhardness of the tool and machined materials in the conditional plane of shear [ 4 ], α is the index, taking into account the influence of cutting temperature on microhardness, erf (P (τ)) is the probability of wear particle separation, p r is normal specific load in the contact zone, E is the modulus of elasticity of the machined material, σ T is the short-term yield strength of the tool material, and μ is Poisson’s coefficient. From the solution of the system of Equations (6)–(8) concerning the cutting tool wear rate, the expression is obtained: J h = p τ ) ⋅ V ⋅ f / ( l 1 + c ) ⋅ b − 0.186 θ ( τ ) J θ V ⋅ ( HV t HV m ) α erfP 1 + μ ) E σ T 2 ] where J d J θ are dimensionless criteria, respectively, considering physical and mechanical properties of the machined material and the character of cutting temperature change. From Equation (9), it follows that the main ways of reducing the intensity of blade cutting tool wear are - Reducing the temperature and cutting force. - Reducing the friction coefficient f (adhesive component) of the frictional contact with the machined material (due to the formation of secondary structures and phases on the working surfaces as products of adaptation (self-organization) of the tribosystem). - HV m and the workpiece HV t (by reducing the dependence of the physical and mechanical properties of the contact surfaces on the temperature in the working zone, considering the phenomena of adaptation (self-organization) during friction) [ 12 , 13 , 23 , 24 , 25 ]. At the present time, the above can be achieved by developing, implementing, and researching innovative multilayer composite coatings on the cutting tool for blade cutting processing, which have not only unique strength properties but also the ability to adapt to external influences with subsequent improvement of operational properties. It is known that the temperature and cutting forces can have a two-fold influence on the intensity of cutting tool wear: on the one hand, increasing temperature reduces the direct effect of the force factor, and on the other hand, increasing temperature leads to the formation of secondary structures and phases on frictional contact with a corresponding change in physical and mechanical properties. Consequently, when creating tool materials and wear-resistant coatings with a friction adaptation effect, it is necessary to consider the specified region of cutting modes and the cutting temperature interval corresponding to this region [ 26 , 27 , 28 , 29 , 30 , 31 ]. 3. Materials and Methods Experimental research during milling was carried out on certified equipment to ensure the reliability of the obtained test results, specifically on vertical milling machines of normal accuracy and rigidity “VM 127M” (Votkinskiy Machine Building Plant, Votkinsk, Russia) and “Knuth WF 4.1” (KNUTH, Wasbek, Germany) ( Figure 1 ). Figure 1 of vertical milling machine “VM 127M” shows the complexity of the equipment for measuring and recording the components of forces and cutting temperature, from left to right: dynamometer amplifier; PC with software “KISTLER” (version 2825A-03-2); PC for recording cutting temperature with TEMS converter for the temperature; millivoltmeter on the machine table; and three-component dynamometer “KISTLER” with a workpiece mounted on it. To investigate wear laws of cutting tools at face milling with carbide end mills (diameter d = 12 mm; number of teeth z = 4; with geometry of cutting part of helix angle ω = 30°; forward angle γ = 10°; and back angle α = 4°) of H10F grade with various coatings, titanium alloys—Ti64 and Ti811—were used as a machined material. Chemical composition, physical and mechanical properties, and heat treatment of the alloys under study are presented in Table 1 and Table 2 . The study of the machinability of titanium alloys in full-scale tests was carried out as applied to the conditions of semifinishing and finishing machining: at n = 2000 rpm; S = 200 mm/min; a e = 5 mm; and a p = 1.5 mm. In this case, as shown by preliminary experiments and analysis of literature data [ 32 , 33 , 34 , 35 , 36 ], in the conditions of finishing and semifinishing cutting, the determining element of tool wear is the wear chamfer on the rear surface of the cutting wedge. Analysis of the rear surface wear profile showed that the average wear of the rear surface along the main cutting edge is characterized by the smallest variability of the wear measurement results. This parameter at constant values of the front and rear angles of the cutting wedge reflects the dimensional wear resistance of the whole tool. Based on the above, the average width of the rear surface wear chamfer (excluding notches) was used as the investigated tool wear parameter. In the process of milling to ensure the identity of the results and to exclude errors of measurement, the width h r of tool wear chamfer on the back surface was measured using the reading microscope MIR-2M with nozzle MOB-I5 accurate to 0.002 mm at the workplace, and when it reached h r = 0.3–0.4 mm, for additional control and photofixation of the wear pattern, a universal motorized stereo microscope with the possibility of telecommunication “Carl Zeiss Stereo Discovery V12” (ZEISS Microscopy, Oberkochen, Germany) with a visualization system based on the video camera “Zeiss Axiocam 503 Color” (ZEISS Microscopy, Oberkochen, Germany) was used ( Figure 2 ). In this case, the wear of the cutter was measured at certain number of passes, and the cutting path length was set to obtain a picture of all stages of the wear curve (section of the running-in, normal, and catastrophic wear). The wear resistance of a cutting tool is characterized by the period of its durability T and is defined as [ 3 , 4 ]: T = l / S m (10) where T is the durability period (min), l is the cutting path length (m), S m is the minute feed rate (m/min), h rl is the relative linear, and h sw is the surface wear: rl = h r . f − h r . in l f − l in or h sw = ( . f − h r . in ) ⋅ 100 ( l f − l in ) ⋅ S . (11) The criterion for the blunting of cutting tools was taken to be r cr = 0.3 mm. The schematic diagram of temperature and force studies during milling is shown in Figure 3 . To obtain information about the average contact temperature during cutting with sufficiently high accuracy, we used the simple and reliable natural thermocouple method. The part (2) and cutter (3) were isolated from each other by an insulator (1) to exclude errors from the so-called “parasitic” thermo-EMF. Measurement of thermo-EMF was carried out in intervals of 10–15 s after the beginning of cutting. The mercury current collector (5), digital voltmeter “Endim” (8), and PC (9) were used for registration and recording of the thermo-EMF value [ 10 ]. Currently, for research purposes, a set of equipment “Kistler” ( Figure 3 ) is used to measure the components of the cutting force, which provides a high degree of accuracy. The main element of the measuring system is a three-component dynamometer by “Kistler” in the form of a bed for fixing the workpiece from the machined material, model 9253B23 (Kistler Group, Winterthur, Switzerland), the appearance of which is shown in Figure 4 . The connection diagram of the main elements of the dynamometer is shown in Figure 5 . The resulting force acting on the dynamometer is proportional to the algebraic sum of the corresponding components of the individual forces, which are formed because of the parallel arrangement, as shown in Figure 6 . Thus, the dynamometer is a multicomponent force sensor, independent of the point of its application. To amplify and convert the signal, we used an 8-channel amplifier and converter type 5070A01110 from “Kistler” (Kistler group, Schweiz), the appearance of which is shown in Figure 7 . Kistler “DynoWare” software (version 2825A-03-2) is used for data collection and analysis. The “DynoWare” software is versatile, easy to use, and compatible with dynamometers or single- and multicomponent force transducers. “DynoWare” provides continuous visualization of the measured curves during signal analysis and has all necessary mathematical and graphical functions. In addition to the simple configuration of the most important measurement tools, “DynoWare” supports the documentation of measurement processes and the storage of configuration and measurement data. Easy operation, setup, and monitoring of “Kistler” measuring instruments via RS-232C or IEEE 488 interfaces; powerful graphic capabilities; useful functions for evaluation and calculations; simultaneous data logging from up to eight measuring channels; and recording and evaluation of any physical quantities are possible. It is known that adhesion wear is most prevalent in machining, and at the same time, to reduce the time to determine the effective coating composition and application modes, as well as reduce the cost of both the tool and cathode material, several adhesion tests were carried out. To estimate the tribotechnical parameters (τ nn , p rn , and τ nn /p rn ), an experimental method [ 25 ] was used. This method is based on the physical model ( Figure 8 ) and the developed setup ( Figure 9 ) [ 12 , 26 ], which in the first approximation reflects real friction and wear conditions at local contact. According to this model, a spherical indentor (1) made of tool material H10F with different coatings (simulating a single rough spot of rubbing solids), squeezed by two plane-parallel samples (2) made of titanium alloys Ti64 and Ti811 (with high accuracy and cleanness of contact surfaces), rotates under the load N around its own axis. The force F ex expended on the indentor rotation and applied to the tether (3) placed in the disk slot (4) is mainly related to the shear strength τ nn of the adhesion bonds. The other end of the cable is connected to the elastic elements (9, 10) and the recording device by means of the wire (11) on which the drive forces for the rotation of the indentor (1) are recorded. Ensuring the temperature regime in the contact zone of the indentor with the samples of the processed material in a wide range of variation (0–1300 °C) uses the electrical contact method, and a high voltage is supplied from the power-controlled transformer to the terminals (5) isolated from the housing. At the same time, tribotechnical characteristics such as adhesive bond shear strength (τ nn ), normal contact stresses (p rn ), and adhesion component of the friction coefficient (f a ) were determined. Examples of samples for adhesion studies are shown in Figure 10 . The surface morphology and microstructure of the coatings were studied by transmission electron microscopy on JEOL JEM-201 OE (Akishima, Japan) with an accelerating voltage of 200 kV. At the same time, the coatings were deposited on the cemented carbide bottom layer with a thickness of 2.5 to 3 μm for observations. Samples were prepared using the FIB ion beam focusing method on the JEOL-JFIM-2100 system and were thinned to 0.1 μm using Ga ions with an accelerating voltage from a Ga ion source of 30 kV and a current of 2.0 mA. The chemical composition of the secondary structures appearing on the cutter surface during cutting was investigated by the SIMS method. The ion etching rate was on the order of 0.2 monolayers per minute, and the analysis was performed in static mode. The atomic structure of the films formed on the tool surface during cutting was investigated using EELFS and an ESCALAB MK 2 (VG) electron spectrometer. The friction surface was investigated in areas free from adhesion of the workpiece material. A high magnification ratio (2000×) was used. The primary electron energy was Ep = 1000 eV. A fine spectral energy loss pattern was recorded close to the elastically scattering electron line in the 250 eV range. The analysis conditions were chosen to provide the best energy resolution with a good signal intensity ratio [ 37 , 38 , 39 , 40 , 41 ]. Nanostructured composite multilayer coatings for adhesion tests on the tool material indentor and wear-resistant coatings for end mills were applied on three different units: “Platit π311” in the laboratory “Coating Technology and Heat Treatment” with (CrAlSi)N, (CrAlSi)N + DLC (diamond-like carbon), (TiAlSi)N, (CrAlSi)N + epilama, (CrAlSi)N + DLC + epilama, and (TiAlSi)N + epilama; modernized NNV-6 6-I1 at the laboratory “Innovative Materials and Coatings” with IDTI RAS-(TiCrAl)N, (ZrCrAl)N, (ZrMoAl)N, and (ZrMoHfCrAl)N; and “Platit π411” at Technopark “Vityaz” with TiB 2 , nACo 3 , nACRo, nACRo+TiB 2 , nACo 3 +TiB 2 , TiB2+epilama, nACo3+epilama, nACRo + epilama, nACo 3 + TiB 2 +epilama, and nACRo+TiB 2 +epilama, with a coating thickness no more than 10 microns. The grain size of these coatings was in the range of 3 to 5 nanometers. The microhardness for the nACo 3 coating was 45 GPa and for the nACRo coating was 42 GPa, with room temperature friction coefficients of 0.35 and 0.45, respectively. At the same time, nACo3–(TiAlSi)N + TiN or AlSiTiN(up) + TiAlSiN + TiN and nACRo–TiAlN or AlCrN is embedded in the amorphous matrix SiN. 4. Experimental Results and Discussion The analysis of the works of researchers allows us to conclude that the solution to the problem of increasing the wear resistance of cutting tools with different coatings is developing in different directions. At the same time, there is practically no data on the results of experimental research with the indication of cutting modes and specific relationships between “tool-machined material”, application modes, and percentage content of wear-resistant coating elements, as well as their operational characteristics (adhesion coefficient, service life, critical cutting path length, and wear on the rear surface of the cutting tool); this does not allow a comparative analysis of the results obtained in this case. In the works [ 36 , 37 , 38 , 39 , 40 , 41 ], in search of solutions to the problem, we followed a way of modeling the alloying components (Ti, Cr, Al, and Si) in the composition of nanocomposite coatings (nc-TiAlN/a-SiN, nc-AlCrN/a-SiN, and nc-AlTiCrN/a-SiN), and the increase in the tool service life by 10%–15% on average does not allow substantiation of the improvement of tribotechnical characteristics of wear-resistant coatings, with regard for possible measurement errors. At the same time, it is known [ 36 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ] that most modern nanostructured multilayer composite coatings used on the cutting tool for blade cutting, under certain contact processes and temperature and force conditions, can improve their tribotechnical characteristics. In particular, - The nanocomposite coating based on aluminum nitride and titanium nACo3 is a high-tech solid coating applied by physical vacuum deposition and consisting of nanoparticles in a binding amorphous matrix. The uniqueness of the coating lies in the successful combination of physically mutually exclusive parameters: while increasing the hardness, its elasticity increases at the same time; - The nanocomposite coating based on chrome and aluminum carbonitrides nACRo has very high hardness at elevated cutting temperatures; - Titanium diboride TiB 2 nanocomposite coating is a synthetic, particularly hard, heat-resistant, refractory, and wear-resistant material. These coatings are advantageous due to their high hardness and resilience as well as good abrasion resistance. - Diamond-like coating (DLC) is a diamond-like carbon material with a tough and friction-reducing coating on top of other conventional wear-resistant coatings in most cases. The results of experimental studies of the wear resistance of cutting tools with different coatings during milling ( Figure 11 , Figure 12 , Figure 13 , Figure 14 , Figure 15 and Figure 16 ) of titanium alloys are presented in the form of graphs of the dependence of tool wear on the rear surface (h r , mm) ( Figure 11 and Figure 14 ) on the critical length of cutting path (l, m) ( Figure 13 and Figure 16 ) and also graphs of the dependence of the durability period on the coating applied to the cutting tool ( Figure 12 and Figure 15 ). The best indices of cutting tool wear resistance (wear on the back surface, critical cutting path length, and tool durability period) were measured as follows: - Milling of titanium alloy Ti64 was ensured when using wear-resistant coatings: improvement by 2.4 times with “nACRo+TiB 2 ” coating, by 2.2 times with “nACo3+TiB2”, and by 2 times with “nACRo” coating compared to milling without coating; - Milling of titanium alloy Ti811 was provided with wear-resistant coating: improvement by 4 times with “nACRo” coating and improvement by 2 times with “nACRo+TiB 2 ” coating in comparison with milling without coating. According to the results of experimental studies, the best indicators of cutting tool wear resistance with different coatings were found as follows: - Milling of titanium alloy Ti64 was provided when using wear-resistant coatings: improvement by 18% with “nACRo + TiB2” coating and by 17% with “nACRo + TiB2 + epilama” coating in comparison with “nACo3” coating; - Milling of titanium alloy Ti811 was ensured when using wear-resistant coatings: improvement by 1.8 times with “nACRo” coating and by 1.5 times with “nACo3 + TiB2 + epilama” coating in comparison with “nACo3” coating. According to the results of field experiments during milling of titanium Ti64 by milling cutters with different durations of titanium diboride application, it was found that - For milling of Ti64 titanium alloy, an increase in TiB 2 coating time of more than 30 min does not contribute to the increase in wear resistance of the milling cutter. The results of the temperature experiments are shown in Figure 17 and Figure 18 . According to the results of temperature studies, it was found that - The lowest cutting temperature value is provided when using “nACRo + TiB 2 ” coating when milling Ti64 and Ti811 titanium alloys, and they are lower by 9% and 12%, respectively, relative to uncoated machining; - Milling of Ti64 titanium alloy is less heat-intensive compared to Ti811. The results of the performed force experiments are shown in Figure 19 and Figure 20 . According to the results of the conducted force tests, it was found that - The lowest value of cutting force is provided when using “nACRo3 + TiB2” coating for both titanium alloy Ti64 and alloy Ti811 with 1.5–2 times less force in comparison with milling without coating; - Milling of titanium alloy Ti64 has less force loading in comparison with Ti811 by 1.5–2 times. The results of adhesion studies are shown in Figure 21 and Figure 22 . Analysis of experimental data has shown that, with increasing contact temperature, the adhesion component of the friction coefficient increases monotonically for all the coatings under study at temperatures corresponding to optimal cutting speeds (according to wear intensity), and the smallest value corresponds to the most favorable composition and technology of their applications. It was found that - The most effective coatings in terms of contact processes on a single contact spot and adhesion coefficient are the coatings applied on “Platit π411”: nACo 3 , nACRo, and nACRo + TiB 2 ; - The lowest coefficient of adhesion interaction between the tool material and the machined material in the whole investigated temperature range is provided by coating nACRo + TiB 2 on titanium alloys Ti64 and Ti811, which confirms the best coating adhesion with the substrate and allows using them for high-speed milling. To explain the mechanism of increasing tribotechnical characteristics of multilayer nanostructured coatings, a series of material science studies of the wells of samples of machined and spherical surfaces of tool materials was carried out ( Figure 23 , Figure 24 and Figure 25 ). The surface morphology and microstructure of the coatings were investigated by transmission electron microscopy on a JEOL JEM-201 OE unit with an accelerating voltage of 200 kV. At the same time, the coatings were deposited on the cemented carbide bottom layer with a thickness of 2.5 to 3 μm for observations. Samples were prepared using the FIB ion beam focusing method on the JEOL-JFIM-2100 system and were thinned to 0.1 μm using Ga ions with an accelerating voltage of 30 kV and a current of 2.0 mA from a Ga ion source. The chemical composition of the secondary structures appearing on the cutter surface during cutting was investigated by the SIMS method. The ion etching rate was on the order of 0.2 monolayers per minute, and the analysis was performed in static mode. The atomic structure of the films formed on the tool surface during cutting was investigated using EELFS and an ESCALAB MK 2 (VG) electron spectrometer. The friction surface was investigated in areas free from adhesion of the workpiece material. A high magnification ratio (2000×) was used. The primary electron energy was E p = 1000 eV. A fine spectral energy loss pattern was recorded close to the elastically scattering electron line in the 250 eV range. The conditions for the analysis were chosen to provide the best energy resolution with a good signal intensity ratio [ 18 , 48 , 49 , 50 , 51 ]. Intensive tribo-oxidation of the cutting tool surface occurs during high-speed machining. Figure 24 shows Auger electron spectra for tools with nACRo wear-resistant coating. The oxidation of the contact surfaces is obvious, as evidenced by the presence of large amounts of oxygen in both spectra. The intense ionic peaks correspond to the adhesion zones of the part material. The Ti line is significantly stretched ( Figure 24 b) in this zone; this is the result of the oxidation process. An increased amount of aluminum oxide is observed in the spectrum of the filtered coatings, which is shown as a shift in the aluminum line to a lower energy zone (60 eV). At the same time, the intensity of the metallic Al LMM line level around 68 eV decreases. Figure 24 a,b show a series of spectra of positive secondary ions for both 3 min of cutting and after 20 min of coating cutting, and Figure 24 c,d show spectra of negative secondary ions for both coatings. In both positive secondary spectra, the TiO line intensity is high, and this is due to intense tribo-oxidation, which forms rutile-like films. However, some aluminum oxide is formed only on the surface of the coatings after 20 min, and this effect can be observed on the spectrum of negative secondary ions ( Figure 24 c). The formation of aluminum oxide films on the cutter surface significantly changes the heat fluxes and heat dissipation into the chip. This is confirmed by images of chip cross-sections after scanning on an electron microscope, and three different zones can be seen in the chip cross-sections. The atomic structure of the films appearing on the wear zone surface during tribo-oxidation of the nACRo coating was compared with the oxide layer obtained during oxidation of the binary TiAl alloy under equilibrium conditions. Figure 26 shows the Fourier transforms because of mathematical consideration of the fine structure of electron spectra close to the line of elastically scattering electrons. The positions of the peaks on the Fourier transforms correspond to the interatomic distances for the closest coordination spheres. The decoding of the data was based on the analysis of known crystal characteristics of oxides formed on the surface. The positions of the main peaks of the Fourier transforms correspond to the interatomic distances associated with the Al 2 O 3 and TiO 2 lattices ( Figure 25 ) [ 51 , 52 , 53 , 54 ]. In general, the results of metallurgical studies state that the use of such coatings contributes to the reduction in friction forces and cutting tool wear due to the formation of titanium and aluminum oxides. Studies of protective film formation at low and moderate cutting speeds show that there is only one type of protective film formed on the surface because of self-organization phenomena [ 17 , 28 , 29 , 30 ]. These films have an amorphous-like structure with high ductility and improved lubricity. More complex phenomena occur during high-speed processing. These are, first, the low-intensity peaks that are found at far atomic distances in the Fourier transforms shown in Figure 25 . From this figure, it can be assumed that the films that form during tribo-oxidation under high-speed processing conditions are amorphous-like. These films of aluminum oxide contribute to the reduction in wear because, due to the low thermal conductivity, they prevent the intensive removal of heat generated during cutting into the body of the cutting tool [ 55 , 56 , 57 , 58 , 59 ]. Figure 26 shows the results of the micro-X-ray spectral analysis of the worn surfaces of the cutting tools with nanostructured coatings. Worn and oxidized areas of the cutter surface revealed aluminum and titanium oxides formed during milling with nACRo nanostructured coatings. 5. Conclusions The thermodynamic model of cutting tool wear is proposed, allowing us to determine ways to reduce the intensity of cutting tool wear and the dissipative function of the tool material shape change during tool wear, and the conditions for improving the wear resistance of the cutting tool using the phenomenon of adaptation (self-organization) under friction are formulated. Experimental studies on the wear resistance of cutting tools with different coatings have shown that, during milling of titanium alloys, a significant increase in wear resistance is provided when using innovative multilayer nanostructured coatings, with an improvement on average of 1.5–2 times. These positive results are associated with a complex set of phenomena occurring in the contact processes: Firstly, there is a significant decrease in temperature–force loading in the cutting zone by an average of 15%–25% both in terms of cutting temperature and cutting force components, and this phenomenon, according to numerous studies, can be explained by the formation of secondary structures on the friction surfaces in the form of aluminum and titanium oxides, which have heat-reflecting (shielding) and lubricating properties; Secondly, it is because of the above reduction in the friction coefficient (adhesive component) in a wide range of temperature changes from 5500 C to 9500 C by 13%–17%. 3. Important in the analysis are the results of metallurgical research, as the obtained data allow one to assert that, in contact processes, there is a phenomenon of adaptation (self-organization) of friction surfaces at cutting by a tool with wear-resistant coatings, promoting the formation of films of various compounds with shielding, protective, and lubricating properties, in particular Al 2 O 3 , TiO 2 , etc. These films have an amorphous-like structure with high plasticity and improved lubricity. This is confirmed by spectroscopic studies and above all by the low-intensity peaks found at long atomic distances on Fourier transforms. Author Contributions Conceptualization, M.S.M.; Methodology, S.R.S. and A.M.M.; Software, A.S.G.; Formal analysis, N.A.S.; Writing—review & editing, A.P.M.; Visualization, D.S.R. All authors have read and agreed to the published version of the manuscript. Funding Vereshchaka, A.S.; Kushner, V.S. 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Schematic diagram of measuring temperature and cutting force components by natural thermocouple method. 1—insulation; 2—workpiece; 3—insulated cutter; 4—chuck; 5—mercury current collector; 6—dynamometer “Kistler”; 7—connecting wire; 8—amplifier–converter; 9—computer for registration of thermal emfs; 10—computer for registration of cutting force components; and 11—connecting bus. Figure 3. Schematic diagram of measuring temperature and cutting force components by natural thermocouple method. 1—insulation; 2—workpiece; 3—insulated cutter; 4—chuck; 5—mercury current collector; 6—dynamometer “Kistler”; 7—connecting wire; 8—amplifier–converter; 9—computer for registration of thermal emfs; 10—computer for registration of cutting force components; and 11—connecting bus. Figure 4. External view of the 9253B23 dynamometer. Figure 4. External view of the 9253B23 dynamometer. Figure 5. Wiring diagram. Figure 5. Wiring diagram. Figure 6. Structure of a three-component dynamometer. (a, b is the distance from the machining point to the center of the sensor; 1–4 is force sensors; M is moment of force). Figure 6. Structure of a three-component dynamometer. (a, b is the distance from the machining point to the center of the sensor; 1–4 is force sensors; M is moment of force). Figure 7. Exterior view of the amplifier and converter type 5070A01110. Figure 7. Exterior view of the amplifier and converter type 5070A01110. Figure 8. Model of frictional contact. 1—Spherocylindrical indenters of the tool material, 2—cylindrical samples of the same machined material, 3—traction cable, 4—disk with a slot for cable 3 and for mounting 1, and 5—electrical wiring. Figure 8. Model of frictional contact. 1—Spherocylindrical indenters of the tool material, 2—cylindrical samples of the same machined material, 3—traction cable, 4—disk with a slot for cable 3 and for mounting 1, and 5—electrical wiring. Figure 9. Installation for adhesion testing. 1—Spherocylindrical indenters of the tool material, 2—cylindrical samples of the same machined material, 3—traction cable, 4—disk with a slot for cable 3 and for mounting 1, 5—electrical wiring, 6—the device for loading, 7—rack-and-gear mechanism, 8—bracket for mounting the elastic element 9 and strain gauge movement 10, and 11—wiring to register movement, N—applied force. Figure 9. Installation for adhesion testing. 1—Spherocylindrical indenters of the tool material, 2—cylindrical samples of the same machined material, 3—traction cable, 4—disk with a slot for cable 3 and for mounting 1, 5—electrical wiring, 6—the device for loading, 7—rack-and-gear mechanism, 8—bracket for mounting the elastic element 9 and strain gauge movement 10, and 11—wiring to register movement, N—applied force. Figure 10. Samples of machined (flat cylindrical heels) and tool materials (finger cylinders with spherical tips on both sides) with different wear-resistant coatings applied. Figure 10. Samples of machined (flat cylindrical heels) and tool materials (finger cylinders with spherical tips on both sides) with different wear-resistant coatings applied. Figure 11. Effect of the cutting path length (l, m) on the value of wear on the rear surface (h r , mm) during milling of titanium alloy Ti64 by carbide cutters of grade H10F with different coatings (n = 2000 rpm, S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 11. Effect of the cutting path length (l, m) on the value of wear on the rear surface (h r , mm) during milling of titanium alloy Ti64 by carbide cutters of grade H10F with different coatings (n = 2000 rpm, S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 12. Durability period when milling titanium alloy Ti64 with tungsten carbide cutters of grade H10F with different coatings. Figure 12. Durability period when milling titanium alloy Ti64 with tungsten carbide cutters of grade H10F with different coatings. Figure 13. Critical path length when milling titanium alloy Ti64 with H10F carbide cutters with different coatings. Figure 13. Critical path length when milling titanium alloy Ti64 with H10F carbide cutters with different coatings. Figure 14. Effect of the cutting path length (l, m) on the value of wear on the rear surface (h z , mm) during milling of titanium alloy Ti 811 by carbide cutters of grade H10F with different coatings (n = 2000 rpm, S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 14. Effect of the cutting path length (l, m) on the value of wear on the rear surface (h z , mm) during milling of titanium alloy Ti 811 by carbide cutters of grade H10F with different coatings (n = 2000 rpm, S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 15. Durability period when milling titanium alloy Ti811 with tungsten carbide cutters of grade H10F with different coatings. Figure 15. Durability period when milling titanium alloy Ti811 with tungsten carbide cutters of grade H10F with different coatings. Figure 16. Critical path length when milling titanium alloy Ti811 with H10F carbide cutters with different coatings. Figure 16. Critical path length when milling titanium alloy Ti811 with H10F carbide cutters with different coatings. Figure 17. Cutting temperature (thermal emf) when milling titanium alloy Ti64 at different spindle speeds (n = 2000 rpm; S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 17. Cutting temperature (thermal emf) when milling titanium alloy Ti64 at different spindle speeds (n = 2000 rpm; S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 18. Cutting temperature when milling titanium alloy Ti811 at different spindle speeds (n = 2000 rpm; S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 18. Cutting temperature when milling titanium alloy Ti811 at different spindle speeds (n = 2000 rpm; S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 19. Total component of cutting force when milling titanium alloy Ti64 at different spindle speeds (S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 19. Total component of cutting force when milling titanium alloy Ti64 at different spindle speeds (S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 20. Total component of cutting force when milling titanium alloy Ti811 at different spindle speeds (S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 20. Total component of cutting force when milling titanium alloy Ti811 at different spindle speeds (S min = 200 mm/min, a e = 5 mm, a p = 1.5 mm). Figure 21. Temperature dependence of frictional characteristics of plastic contact “Ti64-H10F with coatings”. Figure 21. Temperature dependence of frictional characteristics of plastic contact “Ti64-H10F with coatings”. Figure 22. Temperature dependence of frictional characteristics of plastic contact “Ti811-H10F with coatings”. Figure 22. Temperature dependence of frictional characteristics of plastic contact “Ti811-H10F with coatings”. Figure 23. Auger electron spectra of surfaces of worn nACRo-coated inserts: ( a )—at the running-in stage after 3 min from the beginning of cutting; ( b )—at the steady-state stage after 20 min from the beginning of cutting. Figure 23. Auger electron spectra of surfaces of worn nACRo-coated inserts: ( a )—at the running-in stage after 3 min from the beginning of cutting; ( b )—at the steady-state stage after 20 min from the beginning of cutting. Figure 24. Spectra of positive ( a , b ) and negative ( c , d ) secondary ions of the surface of worn nACRo-coated plates: ( a , d )—after 3 min of cutting; ( b , c )—after 20 min of cutting. Figure 24. Spectra of positive ( a , b ) and negative ( c , d ) secondary ions of the surface of worn nACRo-coated plates: ( a , d )—after 3 min of cutting; ( b , c )—after 20 min of cutting. Figure 25. Fourier transforms on the EELFS close to the elastic scattering electrons for films formed on the surface: ( a )—nACRo-coated cutting tool; ( b )—binary TiAl alloy after isothermal oxidation in air. Figure 25. Fourier transforms on the EELFS close to the elastic scattering electrons for films formed on the surface: ( a )—nACRo-coated cutting tool; ( b )—binary TiAl alloy after isothermal oxidation in air. Figure 26. Results of the micro-X-ray spectral analysis. Figure 26. Results of the micro-X-ray spectral analysis. Table 1. Chemical composition of the materials to be machined. Table 1. Chemical composition of the materials to be machined. Main Components, % by Weight Alloy Ti Al V Mo Others Ti64 Basis 5.5–6.75 3.5–4.5 - - Ti811 Basis 7.5–8.5 0.75–1.25 0.75–1.25 - Table 2. Physical and mechanical properties of machined materials. Table 2. Physical and mechanical properties of machined materials. Parameters Alloys Ti64 Ti811 σ, MPa 910 1141–1175 δ, % 7 7.2–9 ψ, % 15 14–16 KCU, J/m 2 2.5 0.19–0.24 KCT, J/m 2 7.85 2.5–4.1 σ 100 /σ T 300 °C 793 - 400 °C 725 - 500 °C 509/705 - 600 °C 372/676 690/725 σ −1 , MPa 284 - t (N = 2 × 10 7 ) °C 550 - σ −1 H , MPa 147 - t (N = 2 × 10 7 , K t = 3.35) °C 550 - σ 0 , MPa 539 - t (N = 2 × 10 4 ) °C 550 - σ −1 H , MPa 284 - t (N = 2 × 10 4 , K t = 3.35) 550 - K 1C , MPa·m 1/2 59–68.7 - AMA Style Migranov MS, Shehtman SR, Sukhova NA, Mitrofanov AP, Gusev AS, Migranov AM, Repin DS. Study of Tribotechnical Properties of Multilayer Nanostructured Coatings and Contact Processes during Milling of Titanium Alloys. Coatings. 2023; 13(1):171. https://doi.org/10.3390/coatings13010171 Chicago/Turabian Style Migranov, Mars Sharifullovich, Semen Romanovich Shehtman, Nadezhda Aleksandrovna Sukhova, Artem Petrovich Mitrofanov, Andrey Sergeevich Gusev, Arthur Marsovich Migranov, and Denis Sergeyevich Repin. 2023. "Study of Tribotechnical Properties of Multilayer Nanostructured Coatings and Contact Processes during Milling of Titanium Alloys" Coatings13, no. 1: 171. https://doi.org/10.3390/coatings13010171 Article Metrics MDPI and ACS Style Migranov, M.S.; Shehtman, S.R.; Sukhova, N.A.; Mitrofanov, A.P.; Gusev, A.S.; Migranov, A.M.; Repin, D.S. Study of Tribotechnical Properties of Multilayer Nanostructured Coatings and Contact Processes during Milling of Titanium Alloys. Coatings 2023, 13, 171. https://doi.org/10.3390/coatings13010171 AMA Style Migranov MS, Shehtman SR, Sukhova NA, Mitrofanov AP, Gusev AS, Migranov AM, Repin DS. Study of Tribotechnical Properties of Multilayer Nanostructured Coatings and Contact Processes during Milling of Titanium Alloys. Coatings. 2023; 13(1):171. https://doi.org/10.3390/coatings13010171 Chicago/Turabian Style
https://www.mdpi.com/2079-6412/13/1/171
/raid1/www/Hosts/bankrupt/TCRAP_Public/040428.mbx T R O U B L E D   C O M P A N Y   R E P O R T E R A S I A   P A C I F I C Wednesday, April 28, 2004, Vol. 7, No. 83 Headlines A U S T R A L I A NATIONAL AUSTRALIA: Brokers Call for Sell Out NATIONAL AUSTRALIA: Director Demands Access to Documents C H I N A  &  H O N G  K O N G DISI LIMITED: Schedules Winding up Hearing for June 9 DRAGON KING: Faces Winding up Hearing FAR EAST: Unveils Appointment of Liquidators FORTUNA INTERNATIONAL: Widens 2003 Net Loss to HK$36.6M GREATER CHINA: Unveils Liquidity, Financial Resources HAINAN TRAVEL: Schedules Winding up Hearing May 12 HENTIFF LIMITED: Court Sets Hearing Date HUALING HOLDINGS: Narrows 2003 Net Loss to HK$76.97M WELL HOPE: Creditors Meeting Set May 5 I N D O N E S I A BANK TABUNGAN: Pefindo Assigns Bonds Ratings * Prudential Life to Appeal Indonesian Court Decision J A P A N GENERAS CORPORATION: Files for Court Protection ISHIKAWAJIMA-HARIMA: R&I Downgrades Rating to BBB+ MITSUBISHI MOTORS: Rolf Eckrodt Steps Down as President MITSUBISHI MOTORS: Unveils March 2004 Production Sales Results MITSUBISHI MOTORS: S&P Comments on DaimlerChrysler Decision NIKKO CORDIAL: Swings to Profit in 2003 NIKKO CORDIAL: Unit Gets Administrative Action K O R E A HYNIX SEMICONDUCTOR: Faces Setback in China Plant Plan JINRO INDUSTRIES: Taihan Electric Buys Firm for US$244M M A L A Y S I A ANSON PERDANA: Adjourns Winding up Petition June 18 ANTAH HOLDINGS: Issues Default Status Update BOUSTEAD HOLDINGS: Lists New Ordinary Shares KILANG PAPAN: Unveils Investigative Audit Results OILCORP BERHAD: Posts Changes in Director's Shareholding OCEAN CAPITAL: Announces Registrar's Change of Address OSK HOLDINGS: Enters Alliance With Equitable Investment OSK HOLDINGS: Announces Listing of New Shares TECHNO ASIA: Slapped with Public Reprimand P H I L I P P I N E S ABS-CBN BROADCASTING: To Raise US$120M to Refinance Debts BAYAN TELECOMMUNICATIONS: Court Orders Creditors' Equal Care FIRST PHILIPPINE: Sets Annual Stockholders Meeting NATIONAL STEEL: SEC Dragging RTC's Sale Approval PHILIPPINE AIRLINES: Takes Extra Care After Strike Threats PHILIPPINE LONG: Issues Notice of Annual Stockholders Meeting PHILIPPINE LONG: Bags Overall Best Managed Company Award S I N G A P O R E CYCAD PTE: Schedules Winding up Hearing FASTHUB PTE: Issues Winding up Order Notice HUA KOK: Posts Changes in Audit Committee LIVONIA INVESTMENTS: Creditors Must Submit Claims by May 21 MURRANNE PTE: Issues Debt Claim Notice to Creditors PERTAMA DEVELOPMENT: Issues Winding Up Order Notice -  -  -  -  -  -  -  - ================= A U S T R A L I A ================= NATIONAL AUSTRALIA: Brokers Call for Sell Out --------------------------------------------- National Australia Bank's continuous boardroom battle has urged brokers to recommend clients' sell their shares.  "An ongoing downward earnings revision cycle continues to plague NAB. We feel this is not over, we believe the potential for further bad news remains." Citigroup Smith Barney said, quoted by The Australian newspaper. ABN Amro has downgraded net profit forecasts for 2004 by 9.1 percent, but it has assumed earnings will be worse than expectations because of NAB's poor profit guidance, however it expects NAB to include writedowns in its general provisions in one hit rather than gradually. NATIONAL AUSTRALIA: Director Demands Access to Documents -------------------------------------------------------- National Australia Bank director Catherine Walter was unable to get a copy of a draft report by PricewaterhouseCoopers (PwC) of the bank's foreign exchange trading scandal, Dow Jones reports. Ms. Walter claims she was prevented access to a copy of the document she to which she previously claimed key changes were made when a copy was circulated to some member of the bank's board. "A draft copy may throw some light on the extent and nature of changes made to the final report. It would provide some indication as to whether the final report was as independent as shareholders were led to believe," Ms. Walter argued. "I have sought from National a copy of the draft PwC report which was considered by the Principal Board Risk Committee members on February 23-24," Ms. Walter added. "The National apparently did not keep a copy in its PBRC record and PwC are not willing to make a copy available to their client, the National. But not getting access to the report, shareholders will be left to draw inferences about the fact it has been withheld," she said. Ms. Walter called on NAB's board to take all steps to make the necessary documents relevant to the investigation available. ============================== C H I N A  &  H O N G  K O N G DISI LIMITED: Schedules Winding up Hearing for June 9 ----------------------------------------------------- Notice is hereby given that a petition for the winding up of Disi Limited by the High Court of Hong Kong was on the 30 March 2004 presented to the said Court by Bank of China (Hong Kong) Limited, whose registered office is situated at 14th Floor, Bank of China Tower, No. 1 Garden Road, Central, Hong Kong. The said petition will be heard before the Court at 9:30 a.m. on the 9 June 2004. Any creditor or contributory of the said company desirous to support or oppose the making of an order on the said petition may appear at the time of hearing by himself or his counsel for that purpose. A copy of the petition will be furnished to any creditor or contributory of the said company requiring the same by the undersigned on payment of the regulated charge for the same. Messrs. Wat & Co. Solicitors for the Petitioner, 12th Floor, Chuang's Tower 30&32 Connaught Road Central Hong Kong Note: Any person who intends to appear at the hearing of the said petition must serve on or send by post to the above named, notice in writing of his intention so to do. The notice must state the name and address of the person, or if a firm or his or their Solicitor (if any) and must be served or if posted, must be sent by post in sufficient time to reach the above named not later than six o'clock in the afternoon of the 8 June 2004. DRAGON KING: Faces Winding up Hearing ------------------------------------- Notice is hereby given that a petition for the winding up of Dragon King Limited by the High Court of Hong Kong was on the 13 April 2004 presented to the said Court by GE Capital (Hong Kong) Limited whose registered office is situated at 8th Floor, Devon House, 979 King's Road, Quarry Bay, Hong Kong. The said petition will be heard before the Court at 9:30 a.m. on the 23 June 2004. Any creditor or contributory of the said company desirous to support or oppose the making of an order on the said petition may appear at the time of hearing by himself or his counsel for that purpose. A copy of the petition will be furnished to any creditor or contributory of the said company requiring the same by the undersigned on payment of the regulated charge for the same. Messrs. Li, Wong & Lam Solicitors for the Petitioner, Unit 2602, 26th Floor, Tower One 89 Queensway Hong Kong Note: Any person who intends to appear at the hearing of the said petition must serve on or send by post to the above named, notice in writing of his intention so to do.  The notice must state the name and address of the person, or if a firm or his or their Solicitor (if any) and must be served or if posted, must be sent by post in sufficient time to reach the above named not later than six o'clock in the afternoon of the 22 June 2004. FAR EAST: Unveils Appointment of Liquidators -------------------------------------------- Far East Gateway Limited (In Compulsory Liquidation) has appointed several liquidators, disclosing that: The Company's Registered Office: 8/F., Pico Tower, 66 Gloucester Road, Wanchai, Hong Kong Joint and Several Liquidators': Mr. Ng Kwok Wai and Mr. David Nip of Messrs Professional Management Consultants Limited Liquidators' Address: Room 701, 7th Floor, Union Park Centre, 771 Nathan Road, Mongkok, Kowloon Members of a Committee of Inspection: (i)   China Netcom Corporation Limited (ii)  Far East Gateway International Limited (iii) Hady Hartanto (iv)  Sri Tjintawati Hartanto (v)   China Netcom (Hong Kong) Operations Limited This Quamnet announcement is dated 14 April 2004. FORTUNA INTERNATIONAL: Widens 2003 Net Loss to HK$36.6M ------------------------------------------------------- Fortuna International Holdings Limited booked a net loss of HK$36.693 million for 2003, versus a net loss of HK$27.953 million a year earlier, according to Infocast News on Tuesday. The Loss per share was $0.009. No final dividend was declared. GREATER CHINA: Unveils Liquidity, Financial Resources ----------------------------------------------------- In September 2003, Greater China Holdings Limited placed 27,598,000 shares at HK$0.221 per share and the net proceeds reached approximately HK$6,000,000. In a disclosure to the Stock Exchange of Hong Kong Limited, the transaction took place in October 2003 and the net proceeds were applied towards the repayment of the margin loans incurred by the Group in the course of investment in securities. In December 2003, the Company further placed 33,100,000 shares at HK$0.231 per share and the net proceeds was approximately of HK$7,600,000. Completion was taken place in January 2004 and the net proceeds were applied as the general working capital of the Group. The Group has a current ratio of approximately 0.42 as at 31 December 2003 (as at 31 December 2002: 1.75) and the gearing ratio was 1.40 as at 31 December 2003 (as at 31 December 2002: 0.85). The calculation of gearing ratio was based on the total borrowing of HK$142,453,000 (31 December 2002: HK$172,979,000) and the net assets of HK$101,648,000 as at 31 December 2003 (31 December 2002: HK$203,340,000). There were no significant capital commitments as at 31 December 2003, which would require a substantial use of the Group's present cash resources or external funding. The Group does not anticipate any material foreign exchange exposure since its cash, borrowings, revenue and expenses are denominated in Hong Kong dollars. CHARGED ON ASSETS As at 31 December 2003, all the Group's investment properties and the issued shares of China Faith Limited, a wholly owned subsidiary of the Company are pledged and the rental income in respect of the investment properties under operating leases are assigned to a bank against a bank loan of HK$138,300,000 (as at 31 December 2002: HK$147,400,000) granted to the Group. Other investments of HK$14,695,000 (31 December 2002: HK$101,431,000) are pledged against margin and other loan facilities granted to the Group. HAINAN TRAVEL: Schedules Winding up Hearing May 12 -------------------------------------------------- Notice is hereby given that a petition for the winding up of Hainan (H.K.) Travel Agency Limited by the High Court of Hong Kong was on the 12 March 2004 presented to the said Court by Hon Yin of 3/F., 177 Fa Yuen Street, Mongkok, Kowloon, Hong Kong. The said petition will be heard before the Court at 9:30 a.m. on the 12 May 2004. Any creditor or contributory of the said company desirous to support or oppose the making of an order on the said petition may appear at the time of hearing by himself or his counsel for that purpose. A copy of the petition will be furnished to any creditor or contributory of the said company requiring the same by the undersigned on payment of the regulated charge for the same. Ms. Ada Chau Ming Wai For Director of Legal Aid 34th Floor, Hopewell Centre 183 Queen's Road East, Wanchai Hong Kong Note: Any person who intends to appear at the hearing of the said petition must serve on or send by post to the above named, notice in writing of his intention so to do.  The Notice must state the name and address of the person, or if a firm or his or their Solicitor (if any) and must be served or if posted, must be sent by post in sufficient time to reach the above named not later than six o'clock in the afternoon of the 11 May 2004. HENTIFF LIMITED: Court Sets Hearing Date ---------------------------------------- Notice is hereby given that a petition for the winding up of Hentiff Limited by the High Court of Hong Kong was on the 29 March 2004 presented to the said Court by Tsang Tak Fu of Room 232, Lee Hang House, Shun Lee Estate, Kowloon, Hong Kong. The said petition will be heard before the Court at 9:30 a.m. on the 9 June 2004. Any creditor or contributory of the said company desirous to support or oppose the making of an order on the said petition may appear at the time of hearing by himself or his counsel for that purpose. A copy of the petition will be furnished to any creditor or contributory of the said company requiring the same by the undersigned on payment of the regulated charge for the same. Ms. Ada Chau Ming Wai For Director of Legal Aid 34th Floor, Hopewell Centre 183 Queen's Road East, Wanchai Hong Kong Note: Any person who intends to appear at the hearing of the said petition must serve on or send by post to the above named, notice in writing of his intention so to do.  The Notice must state the name and address of the person, or if a firm or his or their Solicitor (if any) and must be served or if posted, must be sent by post in sufficient time to reach the above named not later than six o'clock in the afternoon of the 8 June 2004. HUALING HOLDINGS: Narrows 2003 Net Loss to HK$76.97M ---------------------------------------------------- Hualing Holdings reported a net loss of HK$76.97 million for the year ended December 31, versus a net loss of HK$250 million a year earlier, according to the South China Morning Post. The refrigerator and air-conditioner maker had introduced cost- control measures, sparked by a drop in the price of household electrical appliances and a rise in the cost of raw materials, such as steel and cooper. Overall management and sales costs fell about 6 percent and 2 percent respectively compared with 2002. The loss per share was 5.6 HK cents. No dividend was declared. WELL HOPE: Creditors Meeting Set May 5 Notice is hereby given that a meeting of the creditors of Well Hope Industrial Limited will be held at Room 1101, 11/F., Shiu Lam Building, 23 Luard Road, Wan Chai, Hong Kong on 5 May 2004 at 2:30 in the afternoon. Creditors may vote either in person or by proxy. Forms of proxy to be used at the meeting must be lodged at Room 1101, 11/F, Shiu Lam Building, 23 Luard Road, Wan Chai, Hong Kong not later than 4 p.m. on the day before the meeting or adjourned meeting at which they are to be used. By Order of the Board of Well Hope Industrial Limited Yeung Chun Sau Director This Quamnet announcement is dated 23 April 2004. ================= I N D O N E S I A ================= BANK TABUNGAN: Pefindo Assigns Bonds Ratings -------------------------------------------- Pefindo Credit Rating Indonesia assigned a "idBBB+" rating for PT Bank Tabungan Negara (BTNG)'s proposed Bonds X of IDR750 billion and "idBBB" for its Subordinated Bond I of IDR250 billion. At the same time, Pefindo upgraded its ratings for BTNG and Bonds IX/2003 of IDR750 billion to "idBBB+". The ratings reflect BTNG's strong presence in housing ownership loan market (KPR), especially in low to middle income classes, well-managed asset quality, and improving capitalization. Nevertheless, although improving, BTNG still bears relatively high cost of fund due to its unfavorable funding structure, which eventually leads to less favorable profitability ratios compared to that of peers. In addition, BTNG still faces significant maturity mismatch due to its focus on long-term house loans, whereas most of funding are still in the form of deposits that have short maturity. Established under the name of Postpaarbank in 1897, the bank's name was several times changed before it is known as Bank Tabungan Negara in 1963 up until now. In 1974, BTNG was appointed as the housing loan financing institution for low to medium income classes in order to support the government's housing development program. BTNG has tapped bond market since 1989 by issuing its five-year Bond I of IDR50 billion. Since then, BTNG has regularly issued bonds to finance its loan expansion and reduce its maturity mismatch. Similar to other banks, BTNG had suffered huge losses and negative equity following the economic crisis in 1997. As a result, in 2000, the bank was recapitalized with an injection of IDR13.8 trillion recap bonds, which subsequently made the bank's CAR sharply increase to 8.7% from minus 288.1%. Following the recapitalization program and more conservative lending, BTNG has gradually improved its performance in the past three years. As of December 2003, BTNG booked total assets of IDR26.8 trillion, which placed it as the 8th largest bank in the country. The bank's operation is supported with 44 branches, 59 sub-branches, 88 cash offices and 171 fully owned ATMs in addition to more than 4,000 units of ATM HIMBARA. As to date, the Government of Indonesia (GOI) still holds 100% ownership of BTNG. * Prudential Life to Appeal Indonesian Court Decision ----------------------------------------------------- In a company press release PT Prudential Life Assurance disclosed that it recently terminated a consultancy contract for agency sales force management, following legal advice. As a result, the consultant has made a claim against PT Prudential Life Assurance for approximately US$40 million and has filed a bankruptcy petition in the Jakarta Bankruptcy Court. The Company considers, on the basis of its legal advice, that the bankruptcy petition is ill conceived. Jakarta's Bankruptcy Court returned its verdict Friday. It held that the Company owes the consultant approximately US$ 400,000 and as a result, has put the Company into bankruptcy. PT Prudential Life Assurance is very surprised that the Court has decided to accept the petition filed against it. PT Prudential Life Assurance plans to vigorously appeal the Jakarta Bankruptcy Court's decision. While the appeal process is underway, Prudential' s operations in Indonesia intend to continue business as usual. All Prudential policies remain completely unaffected and our total commitment to our customers and our employees continues undiminished. PT Prudential Life Assurance is financially very strong. Its Risk Based Capital (RBC) ratio of 255% (as at December 31, 2003) compares very favorably with the 100% requirement dictated by the Ministry of Finance. ENQUIRIES TO: Media Investors/ Analysts Geraldine Davies: 0207 548 3911 Steve Colton: 020 7548 3721 Rebecca Burrows: 020 7548 3537 Clare Staley: 020 7548 3719 Marina Lee-Steere:  020 7548 3511 ========= J A P A N ========= GENERAS CORPORATION: Files for Court Protection ----------------------------------------------- Generas Corporation has filed with the Tokyo District Court for protection from creditors under the fast-track corporate rehabilitation law, according to Kyodo News. The real estate developer has total liabilities of 23.3 billion yen. The Company's principle activity is to operate real estate. The Company is also involved in the hotel/tourism business. Real estate operations including construction and sales of condominiums and apartments and rental and leasing of apartments and buildings accounted for 77 percent of 2001 revenues; hotel operations, 20 percent and others, 3 percent. ADDRESS: Web site: http://www.chisan-tokan.co.jp/ 7-8 Shibuya 1-Chome Shibuya-Ku 150-0002, Tokyo 150-0002 Japan BOARD OF DIRECTORS: President - Takeshi Watanabe Senior Managing Director - Masayuki Kato Managing Director - Yoshihiro Gondo Managing Director - Kenji Fukuchi ISHIKAWAJIMA-HARIMA: R&I Downgrades Rating to BBB+ -------------------------------------------------- Rating and Investment Information, Inc. (R&I) has removed the following ratings of Ishikawajima-Harima Heavy Industries Co., Ltd. from the Rating Monitor scheme and has downgraded them as follows: Senior Long-term Credit Rating; Long-term Bonds (9 Series) Preliminary Rating for the Shelf Registration scheme R&I RATING: BBB+; (Downgraded from A-; Removed from the Rating Monitor scheme) Domestic Commercial Paper Programme R&I RATING: a-2; (Downgraded from a-1; Removed from the Rating Monitor scheme) RATIONALE: Ishikawajima-Harima Heavy Industries (IHI) has recorded a consolidated net loss of 39 billion yen for the fiscal year ended March 2004. This is a result of profit deterioration in some projects, primarily in the energy and plant operations and the shipbuilding and offshore operations, and changes to accounting basis for recording accrued loss on sales contracts. In view of the downward revision of business results on March 15, R&I placed the Senior Long-term Credit Rating and other ratings for IHI on its Rating Monitor scheme with a view to downgrading the company's ratings on March 16 and have been conducting a review. R&I had concerns about the expansion in business risk accompanying IHI's active involvement in overseas business and engineering. This substantial loss means that heightened business risk has become a reality due to the effect of sharp rises in raw material prices and the appreciation in the yen. In addition, optimistic estimates of cost and technical difficulty, mainly for overseas business, have led to significant cost increases. Equity capital has also declined significantly, and R&I consider that IHI's financial resilience to risk is lower than in the past. R&I has downgraded the company's Senior Long- term Credit Rating to BBB+, and the rating for its Commercial Paper program to a-2 and has removed it from the Rating Monitor scheme. However, there are some cases that long-term large-scale projects incur a large additional cost and a company suffers losses only when the construction is nearing its end. While the risk for these projects is not apparent now, it certainly cannot be said that problems will definitely not arise in the future. From this perspective, R&I believes although IHI has accumulated reserves, it will not be able to cover all risks. There is a possibility that the company's rating will be reviewed when additional loses arise. In the near future, R&I intends to make additional careful study of the changes in business risk due to the strengthening of overseas business and engineering, the latent risk in ordered projects and the effectiveness of whole company risk management. MITSUBISHI MOTORS: Rolf Eckrodt Steps Down as President ------------------------------------------------------- Mitsubishi Motors Corporation (MMC) announced that Rolf Eckrodt resigned his post as CEO and President effective as of April 26, 2004. In a Company press release, MMC will appoint a new President, Representative Director, soon. Until this appointment, Keiichiro Hashimoto, board member and Chief Financial Officer, will oversee ongoing business as interim acting President. Eckrodt joined MMC in January 2001 as Chief Operating Officer in charge of MMCs passenger car operations. On June 25, 2002, Eckrodt was elected president and CEO of MMC, a position he held until Monday. During his tenure Eckrodt oversaw the successful implementation of various restructuring measures and far-reaching business reforms, the spin-off of the company's truck and bus operations as well as a significant improvement of the operational business in all regions except North America. Commenting on the timing for his resignation, Eckrodt pointed to the decision of the Supervisory Board of DaimlerChrysler neither to participate in a capital increase nor to grant further financial support to Mitsubishi Motors Corporation, which was announced last Thursday. "I strongly welcome the quick decision of Mitsubishi Heavy Industries, Mitsubishi Corporation and Bank of Tokyo-Mitsubishi not only to offer financial support but also to actively work with Mitsubishi Motors Corporation on a new mid-term business plan as announced last Friday. Based on my sense of responsibility, I therefore decided to make way for the new team around future chairman Okazaki," Eckrodt said. The business revitalization team headed by Mr. Okazaki will work out this plan within the next month based on various essential steps that have already been analyzed and evaluated by MMC so far," Eckrodt added. Eckrodt also voiced his wish that MMC and especially its many motivated and excellent employees will continue the numerous positive processes initiated. "I hope that the support from the shareholders side will ensure a prosperous and successful future not only of MMC, but in the same degree also to our domestic and international business partners, and of course most importantly to our customers," he said. Eckrodt will also retire from a 38-year full-time career in the automotive business, which he started at Daimler-Benz (today DaimlerChrysler) in 1966. At the request of Mitsubishi group companies, Eckrodt will remain available to provide support for MMC. ROLF ECKRODT Date & Place of Birth: June 25, 1942 / Gronau (Westphalia), Germany Education: 1966 Diploma in Mechanical Engineering University of Bochum / Germany PROFESSIONAL EXPERIENCE 06/2002 President and Chief Executive Officer, Mitsubishi Motors Corporation 01/2001 Executive Vice President and Chief Operating Officer Mitsubishi Motors Corporation 12/1998 President and Chief Executive Officer Adtranz - DaimlerChrysler Rail Systems GmbH 08/1996 Executive Vice President and Deputy Chief Executive Officer Adtranz - ABB Daimler-Benz Transportation GmbH and Chairman of the Board of Management Adtranz - ABB Daimler-Benz Transportation (Deutschland) GmbH 05/1992 President Mercedes Benz do Brasil, S.A. Commercial Vehicles, Trucks and Buses 01/1990 Director worldwide Sales and Marketing Passenger Cars Mercedes-Benz AG 09/1987 Director Planning and Production Passenger Cars and Components Daimler-Benz AG 04/1986 Executive Assistant to the Head of the Mercedes-Benz Passenger Car Division 02/1983  Vice President Axle Production Passenger Cars Daimler-Benz AG 1981 Project Leader Production Components Passenger Cars Daimler-Benz AG 1968 Manager Passenger Cars Daimler-Benz AG 04/1966 Quality Assurance Passenger Cars Daimler-Benz AG ADDITIONAL ASSIGNMENTS 04/1999 Honorary Consul of Brazil in Potsdam/Germany 1999 - 2000 Chairman of UNIFE (Union of European Railway Industries) 1993 - 1996 Honorary Degree as Consulate of the Federal Republic of Germany in Brazil 1993 - 1996 Vice President German/Brazil Chamber of Commerce Sao Paulo, Brazil MITSUBISHI MOTORS: Unveils March 2004 Production Sales Results Mitsubishi Motors Corporation (MMC) on Monday announced the production, domestic sales, and export results for March 2004 and the fiscal year ended 31 March 2004. In a Company press release, global production in March totaled 147,438 units, a decrease of 7.1 percent compared to March last year. Output in Japan increased 4.5 percent to 78,655 units on the back of added production of minicars such as the Minicab van and truck. Offshore production slipped 17.6 percent to 68,783 units. Production in Asia declined 11.8 percent to 46,895 units, North American output decreased 41.3 percent to 10,831 units, and European production was off 9.7 percent at 5,786 units. March sales in Japan decreased 3.5 percent on year to 59,779 units. Of this, registrations, which exclude 660cc minicars, declined 17.8 percent to 21,243 while minicars grew 6.7 percent to 38,536 units. MMCs share of the domestic market in March was 7.2 percent, down from 7.5 percent in March last year. Exports from Japan declined 12.7 percent on year to 34,175 units. By region, exports to Asia jumped 51 percent to 6,122 units, exports to North America decreased 66.6 percent to 5,183 and European-bound shipments increased 13.3 percent to 11,167 units. FISCAL 2003 RESULTS Total worldwide production in fiscal 2003 declined 9.4 percent on year to 1,537,469 units. Japanese output inched down 1.9 percent to 751,843 units. Of this, passenger car production dropped 6 percent to 638,919 units while commercial car output increased 30.1 percent to 112,924 units. Offshore production for the year came to 785,626 units, a 15.5 percent decline compared to fiscal 2002. Production in Asia declined 11.5 percent to 501,337 units, North American output decreased 25.4 percent to 156,859 units, and European production was off 14.3 percent at 75,276 units. Domestic sales returned to growth for the first time in eight years in fiscal 2003. MMC saw sales in Japan rise 1.1 percent on year to 358,253 units. Registrations gained 1.5 percent to units. MMCs share of the overall domestic market, which includes trucks and buses, was 6.1 percent, up from 6 percent in fiscal 2002. For the passenger car only market, MMCs share rose from 6.6 percent to 6.8 percent despite a 2 percent drop in overall demand. The Company also saw sales return to growth in Europe after four years of continuous decline, selling 213,700 units across Europe for a 7 percent gain on year. Sales in Asia increased to 680,200 units for the year, representing a new record high in this important growth region. In particular, sales in China surged 65.8 percent to 151,000 units. Exports from Japan declined 12 percent to 376,103 units. As a result of the spin-off of MMCs truck and bus operations in January 2003, regional year-on-year comparisons are not available for the fiscal 2003 period due to a change in the system used by the company to tally exports. by DaimlerChrysler AG not to participate in a capital increase planned by Mitsubishi Motors Corporation and to cease further financial support for the carmaker has no direct effect on the group's credit rating. Although this decision limits the uncertainty about potential future cash contributions from DaimlerChrysler into MMC, it also brings into question a key component of Chrysler's turnaround strategy to improve its cost structure by sharing platforms and procurement activities with MMC. It is not clear to us that MMC will--under all potential scenarios--meet its contractual requirements. In view of these uncertainties, Standard & Poor's views this development as slightly negative. Had the company chosen to increase its involvement in MMC, however, the consequences might have been even more disadvantageous. Nevertheless, Standard & Poor's will closely monitor existing cooperations between MMC and DaimlerChrysler operations. We also consider it likely that there will be an impairment of the value of DaimlerChrysler's stake in MMC (book value about EUR960 million at Dec. 31, 2003). The strong operating and financial performance of group divisions, including the Mercedes Car Group, Services, and Commercial Vehicles, which is expected to continue in 2004, provides sufficient leeway in the rating to sustain this development. 2003 for the first time in three years, buoyed by stock market rally, according to Kyodo News. In its consolidated earnings report for the year to March 31, the Company posted a group net profit of 38.70 billion yen, a reversal from a loss of 21.61 billion yen a year earlier. For a copy of the Company's consolidated financial summary for the year ended 31 March 2004, go to http://bankrupt.com/misc/tcrap_nikkocordial0428.pdf NIKKO CORDIAL: Unit Gets Administrative Action consolidated subsidiaries of Nikko Cordial Corporation, received an administrative action from Japan's Financial Services Agency (FSA). The FSA determined that NCTB violated certain requirements in its trust business. The regulatory authorities also identified shortcomings in compliance and internal control functions. In a Company press release, in accordance with an order from the FSA, NCTB will be suspended from accepting new customers for its custody and clearing services from April 30, 2004. The suspension does not apply to any existing custody business or to custody services related to debt liquidation. NCTB's other non-custodial businesses also remain unaffected. After November 1, 2004, NCTB can request that the FSA review the suspension order pending progress made on the business improvement plans. Nikko Cordial Corporation will give NCTB a great effort to backup. K O R E A HYNIX SEMICONDUCTOR: Faces Setback in China Plant Plan Hynix Semiconductor Inc.'s plan to set up a chip-manufacturing factory in China faced a major setback Monday as creditors disapproved its financing plan and expressed concern over who would manage the plant, according to the Korea Times. Hynix had planned to secure an annual production capacity of 20,000 units of 200mm wafers and 17,000-20,000 units of 300mm wafers from late next year in the China plant. The estimated factory plant could cost US$1.5 billion. The chipmaker was nearly bankrupt two years ago when a glut in the global semiconductor market forced consolidation and a shift to flash memory chips. JINRO INDUSTRIES: Taihan Electric Buys Firm for US$244M ------------------------------------------------------- Taihan Electric Wire Co. recently bought a quarter interest in Jinro Industries Co.'s debt for 280 billion won (US$244 million), in an effort to acquire the financially weak cable maker, Yonhap News reports. Goldman Sachs controls about a third of Jinro's 2.9 trillion won debts and had been pushing for a sale of the distiller, which has been under court receivership since last May, through an auction, TCR-AP reported recently. Jinro currently controls 55 percent of the domestic soju market in South Korea and reported 643.3 billion won in revenue in 2003. =============== M A L A Y S I A =============== ANSON PERDANA: Adjourns Winding up Petition June 18 --------------------------------------------------- Anson Perdana Berhad (Anson) announced that the hearing on 23 April 2004 in respect of the winding-up petition served on the Company by Jethsuch Sdn Bhd has been adjourned to 18 June 2004. This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. ANTAH HOLDINGS: Issues Default Status Update -------------------------------------------- Antah Holdings Berhad announced that further to the Company's announcement on 25 March 2004, there are no further developments in respect of the default in payments of the various credit facilities to the financial institutions and non-financial institutions. Antah is currently in the process of discussion and negotiations with the lenders and creditors for the adoption of a proposed debt-restructuring scheme. This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. BOUSTEAD HOLDINGS: Lists New Ordinary Shares -------------------------------------------- Boustead Holdings Berhad (BSTEAD) would like to announce that its additional 671,000 new ordinary shares of RM0.50 each issued pursuant to the BSTEAD-Employees' Share Option Scheme, will be will be granted listing and quotation with effect from 9 a.m., Wednesday, 28 April 2004. This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. KILANG PAPAN: Unveils Investigative Audit Results ------------------------------------------------- Kilang Papan Seribu Daya Berhad (KPSD) is a PN4 Company currently listed on the Second Board of Bursa Malaysia. A restructuring scheme was subsequently formulated and approved in accordance to the Pengurusan Danaharta Nasional Berhad Act, 1998. The Securities Commission in granting their approval to the restructuring scheme of KPSD (which includes the transfer of listing status to West Coast Forest Industries Berhad) imposed that KPSD appoint an experienced independent audit firm to carry out an investigative audit on the past losses incurred by the KPSD group. The Company is required to take the necessary steps to recover the losses incurred by the KPSD group. Furthermore based on the findings of the investigative audit, KPSD is required to make reports to the relevant authorities if it is established that there have been breaches of law, regulations, guidelines and/or KPSD's memorandum and articles of association that are related to the board of Directors of KPSD and/or any other parties that have caused the said losses of the KPSD group. In compliance with the Securities Commission's requirement, the Company appointed Messrs Anuarul Azizan Chew & Co (AAC) on 26 February 2002 to carry out an investigative audit. On 31 October 2003, two copies of the investigative audit reports issued by AAC were submitted to the Securities Commission in accordance with their requirements. This announcement is made in accordance with the requirements of the Securities Commission following their approval of the restructuring scheme of KPSD dated 28 December 2002. For a copy of the summary of transactions investigated by AAC, go to http://bankrupt.com/misc/tcrap_kilanpapan0428.doc This Bursa Malaysia Securities Berhad announcement is dated 27 April 2004. OILCORP BERHAD: Posts Changes in Director's Shareholding -------------------------------------------------------- Oilcorp Berhad Director Mohamed Hazali Bin Dato' Seri Abu Hassan has the intention to deal in the shares of the Company, which is currently in the closed period pending announcement of its results for the first quarter ended 31 December 2004. His current shareholdings are as follows: Name of Director: MOHAMED HAZALI BIN DATO' SERI ABU HASSAN Direct         Indirect No. of Shares    % of the Company's issued and paid-up share capital 2,592,100        1.71 Direct           Indirect No. of Shares    % of the Company's issued and paid-up share capital 3,994,800        2.64 This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. OCEAN CAPITAL: Announces Registrar's Change of Address ------------------------------------------------------ Ocean Capital Berhad announced on the Bursa Malaysia Securities Berhad on 26 April that the company's share registrar Signet Share Registration Services Sdn Bhd has moved from its old address at the 11th Floor, Tower Block, Kompleks Antarabangsa, Jalan Sultan Ismail 50250 Kuala Lumpur on 26 April 2004. Signet Share is now located at Level 26, Menara Multi Purpose, Capital Square, No. 8, Jalan Munshi Abdullah, 50100 Kuala Lumpur. They may be contacted at telephone number 03-27212222 or facsimile number 03-2721530 / 03-27212531. This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. OSK HOLDINGS: Enters Alliance With Equitable Investment ------------------------------------------------------- The Board of Directors of OSK Holdings Berhad wishes to announce the Company has entered into a Shareholders Agreement with Equitable Investment Co. (Hong Kong) Ltd (EIC). In view thereof, a 50:50 joint venture company, OSK Wealth Planners Sdn Bhd (Company No. 650122-A) (OSKWP) was formed 22 April 2004 to carry on the business of integrated financial planning to high net worth clientele as governed in the Shareholders Agreement dated 26 April 2004. The initial authorized share capital of OSKWP is RM100,000, divided into 100,000 Ordinary Shares of RM1.00 and presently its paid-up share capital is made up to 2 Ordinary Shares of RM1.00 each. PARTIES TO THE JOINT VENTURE OSK Holding Berhad is a company incorporated in Malaysia on 1 November 1990 and listed on the Main Board of Bursa Malaysia Securities Berhad (formerly known as Malaysia Securities Exchange Berhad) (BMSB). The present paid-up share capital of OSK is RM619,127,961, comprising  619,127,961 ordinary shares of RM1.00 each. EIC is a company incorporated in British Virgin Islands on 1 October 1990. The principal activity of EIC is an investment company. DETAILS OF THE JOINT VENTURE The Shareholders Agreement between the Company and EIC is not subject to the approval of the shareholders of OSK or any other authority. FINANCIAL EFFECT OF THE JOINT VENTURE There is no effect on the issued and paid-up share capital of OSK. The joint venture is not expected to have any material effect on the earning and net tangible assets of OSK Group for the financial year ending 31 December 2004. DIRECTORS' AND MAJOR SHAREHOLDERS' INTEREST None of the existing Directors and/or Major Shareholders of OSK and persons connected to them have any interest, whether direct or indirect in the Shareholders Agreement. DIRECTORS' RECOMMENDATION The Directors of OSK are of the opinion that the joint venture between the Company and EIC is in the best of the Group. This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. OSK HOLDINGS: Announces Listing of New Shares --------------------------------------------- OSK Holdings Berhad (OSK) would like to announce that the Company's additional 12,000 new ordinary shares of RM1.00 each issued pursuant to the OSK-Executive Share Option Scheme will be will be granted listing and quotation with effect from 9 a.m., Wednesday, 28 April 2004. This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. TECHNO ASIA: Slapped with Public Reprimand Huat Berhad had assumed the listing status in place of TECASIA. Paragraph 9.16(1)(a) of the LR states that the contents of a press or other public announcement is as important as its failing to take into account some significant items in the Company's fourth quarterly report for the financial year ended 31 December 2002 (FYE 31 December 2002) which was announced to Bursa Malaysia Securities Berhad on 28 February 2003. These items were only adjusted in the audited accounts for the FYE 31 a variation between the un-audited profit after taxation and minority interest of RM10.2 million and the audited profit after taxation and minority interest of RM71.5 million for the FYE 31 December 2002. The public reprimand was imposed pursuant to paragraph 16.17 of the LR after taking into consideration all relevant factors, including the fact that TECASIA has previously breached the listing requirements of Bursa Malaysia Securities Berhad and after consultation with the Securities Commission. PREVIOUS PUBLIC REPRIMAND (a) On 21 May 1998, TECASIA was publicly reprimanded for breach of Section 57 of the Main Board Listing Requirements (MBLR) for failing to furnish the preliminary financial statement for the financial year ended 31 December 1997 within the timeframe stipulated. (b) On 16 October 1998, TECASIA was publicly reprimanded for breach of Section 60 of the MBLR for failing to furnish the Annual Report for the financial year ended 31 December 1997 within the timeframe stipulated. (c) On 24 February 2001, TECASIA was publicly reprimanded for breach of Sections 34 and 341(1) of the MBLR. TECASIA had failed to make an immediate announcement pursuant to Section 34 of the Westmont Mount Austin Sdn Bhd (WMA), a wholly owned subsidiary company of the Company. The Company had also breached Section 341 of the MBLR in respect of the announcement on the appointment of receiver and manager on WMA dated 5 January 2000 as the contents of the said announcement contradicted with its subsequent announcement dated 12 January 2000. (d) On 6 October 2001, TECASIA was publicly reprimanded and fined RM25,500 for breach of Section 60(b) of the MBLR for failing to furnish the annual audited accounts for the financial year ended 31 December 2000 within the timeframe stipulated. This Bursa Malaysia Securities Berhad announcement is dated 26 April 2004. Exchange that it is in the process of negotiating with a syndicate of private banks to raise US$120 million to refinance the Company's existing debts and to fund further investments in cable television operations. certain equipment and other assets and will be guaranteed the certain of the company's subsidiaries. It has been the Company's practice to inform the exchange of any developments in line with this planned fund raising activity that will have a significant impact on the operations and financial performance of the company. This information is being submitted in compliance with the rules of the Securities and Exchange Commission and the Philippine Stock Exchange. Pasig court to treat both secured and unsecured creditors equally until the company has completed its financial rehabilitation, according to the BusinessWorld online. The order, which came out on April 19, states that secured and unsecured creditors should be placed in equal footing during debt repayment.  Nobody should be paid ahead of the other without insolvency or liquidation proceedings. "The court rules that pari passu is applicable and it applies to all creditors of BayanTel, whether secured or unsecured, in the rehabilitation proceedings at bar," the court said. the mortgage if the credit has already matured and is not paid. A preference is an exception to the general rule. Hence, the law on preference of credits is strictly construed," it added. BayanTel's secured creditors include the Philippine National Bank, Development Bank of the Philippines, Land Bank of the Philippines, United Coconut Planters Bank, and Asian Finance & Investment Corp., which the telecommunications company owes $277 million their assets placed as collateral. Unsecured bondholders are Avenue Asia Investments, L.P., Avenue Asia International Ltd., Avenue Asia Special Situations Fund II, L.P., Avenue Asia Capital Partners, L.P., and Van Eck Global Opportunity Masterfund Ltd., BayanTel owes this group $200 million dollars. But both creditors as well as BayanTel oppose the pari passu ruling for it allegedly violates the non-impairment of contract clause in the constitution.  But the Pasig court's defense is that the privilege of BayanTel to prioritise the secured creditors is just suspended so the company does not impair its contractual obligations with banks. "Rehabilitation is not liquidation but to rescue the distressed corporation and continue its operations. If one creditor is preferred to the others, the rationale behind the rehabilitation to effect a feasible and viable rehabilitation cannot be achieved," the court said. It also said "equality of treatment" of BayanTel creditors would stay until the termination of the company's rehabilitation. First Philippine Holdings Corp. submits to the Philippine Stock Exchange a notice on the Annual Stockholders Meeting to be held on May 17, 2004, Monday at 3:00 p.m. at the Meralco Theater, Lopez Building, Ortigas Avenue, Pasig City.  These matters will be discussed. (1) Call to Order (2) Proof of Required Notice (3) Determination of Quorum (4) Approval of the Minutes of the June 9, 2003 Stockholders Meeting (5) Reports of the Chairman and the President (6) Approval of the December 31, 2003 Reports and the Audited Financial Statements. (7) Ratification of the Acts of the Board, of the Executive Committee and of Management. (8) Delegation of Authority to the Board relating to the amendment of the By-Laws incorporating the procedures for the nomination and election of independent directors. (9) Election of Directors (10) Appointment of External Auditors (11) Other Matters (12) Adjournment For the purpose of the meeting, only stockholders of record as of April 16, 2004 are entitled to attend and to vote in the said meeting. Should you be unable to attend the meeting in person, you may want to execute a proxy in favor of a representative.  The company encloses a proxy form for your convenience.  For validation, proxies must be received by the undersigned through our Stock Transfer Agent, Securities Transfers Services Inc. 4th Floor, Benpres Building, Exchange Road cor. Meralco Avenue, Pasig City on or before May 10, 2004 NATIONAL STEEL: SEC Dragging RTC's Sale Approval National Steel Corporation's (NSC) sale to the Indian firm Global Infrastructure Holdings Inc. (GIHL) may not push through for the Securities and Exchange Commission (SEC) is holding back its approval of the deal amid a legal issue, according to The Manila Times. The agreement between NSC and GIHL is supposed to be completed by Wednesday, April 28, but SEC has not given their approval for the deal yet, SEC chair Lilia R. Bautista said. Ms. Bautista said she was still waiting for the Quezon City Regional Trial Court to issue a temporary restraining order (TRO), as recently requested by a landowner against the SEC and the SEC-appointed liquidator for NSC, Danilo Concepcion. According to a report by TCR-Asia Pacific recently, a land dispute that resulted to a filing of a temporary restraining order of the lots owner against NSC has derailed the sale of the steel company to GIHL. PHILIPPINE AIRLINES: Takes Extra Care After Strike Threats ---------------------------------------------------------- Bangkok police announced on Monday that Philippine Airlines (PAL) was threatened by a group saying it would strike at the airline's offices.  The campaign is believed linked to U.S.-led operations in Iraq, according to AFX-Asia. The reported threat was issued in Thailand by a group which has targeted Asian embassies, flights and tourist spots.  However, PAL's flight operations are normal and the carrier is cooperating with authorities in Thailand and Philippines, PAL spokesman Rolando Estabillo said in a statement. "Philippine Airlines is taking all necessary precautions vis-a- vis this threat. PAL is closely coordinating with Thai and Philippine authorities to ascertain the veracity of the threat and deal with it accordingly," Mr. Estabillo said. The Philippines government has rejected calls to bring home a small military and police contingent serving with the US-led occupation forces in Iraq, though it has restricted them to camp and suspended plans to send reinforcements, AFX-Asia reports. PHILIPPINE LONG: Issues Notice of Annual Stockholders Meeting ------------------------------------------------------------- Philippine Long Distance Telephone Company (PLDT) furnished the Philippine Stock Exchange a copy of its Definitive Information Statement in connection with its Annual Stockholders' Meeting, which will be held on June 8, 2004 at 4:00 p.m. at the Grand Ballroom, Dusit Hotel Nikko, Ayala Center, Makati City. As previously announced, "(t)he Board of Directors has fixed April 9, 2004 as the record date for the determination of stockholders entitled to notice of, and to vote at, said Annual Meeting." Attached is a copy of the Notice of Annual Meeting of Stockholders. A copy of TEL's Definitive Information Statement shall be made available for reference at the PSE Centre and PSE Plaza libraries. The same shall likewise be made available for downloading at the PSE website: www.pse.com.ph (under Listed Companies). PHILIPPINE LONG: Bags Overall Best Managed Company Award -------------------------------------------------------- In a company press release Philippine Long Distance Telephone Co. disclosed that: After commemorating its 75th year as the telecommunications giant, PLDT has another reason to celebrate. Asia Money, one of the most influential and trusted financial magazines in Asia, has recently recognized PLDT as the Philippines Overall Best Managed Company. PLDT was chosen by over 200 investors from 180 institutions worldwide in the 12th annual survey conducted by Asia Money. It has also garnered first in the following categories: - Best Corporate Strategy - Best Financial Management - Best Investor Relations - Best Focus on Shareholder Value - Best Operational Efficiency - Most Improved in Corporate Governance ================= S I N G A P O R E ================= CYCAD PTE: Schedules Winding up Hearing --------------------------------------- Notice is hereby given that a petition for the winding up of Cycad (Singapore) Pte Ltd by the High Court was on the 14 April 2004 presented by Yeung Hi Hung. The said petition will be heard before the Court sitting at the High Court in Singapore at 10 o'clock in the forenoon on the 7 May 2004. Any creditor or contributory of the said Company desiring to support or oppose the making of an order on the said Petition may appear at the time of hearing by himself or his Counsel for that purpose and a copy of the Petition will be furnished to any creditor or contributory of the said Company requiring the same by the undersigned on payment of the regulated charge for the same. The Petitioner's address is Blk 155, Hougang Street 11 #02-184, Singapore 530155. The Petitioner's Solicitors are Messrs A.Ang, Seah & Hoe of 141 Market Street, #06-01 International Factors Building, Singapore 048944. Messrs A.ANG, SEAH & HOE Solicitors for the Petitioner. Note: Any person who intends to appear at the hearing of the said Petition must serve on or send by post to the above named Messrs A. Ang, Seah & Hoe of 141 Market Street, #06-01 International Factors Building, Singapore 048944, notice in writing of his intention so to do. The notice must state the name and address of the person, or, if a firm, the name and address of the firm, and must be signed by the person or firm, or his or their Solicitors (if any) and must be served, or if posted must be sent by post in sufficient time to reach the above-named not later than twelve o'clock noon on the 6th day of May 2004 (the day before the day appointed for the hearing of the Petition). FASTHUB PTE: Issues Winding up Order Notice ------------------------------------------- Fasthub Pte Ltd issued a notice of winding up order made on the 16 April 2004. Name and address of Liquidator: The Official Receiver 45 Maxwell Road #05-11/#06-11 The URA Centre (East Wing) Singapore 069118. Messrs Wong Partnership Solicitors for the Petitioner. This Singapore Government Gazette announcement is dated 26 April 2004. HUA KOK: Post Changes in Audit Committee The Board of Directors of Hua Kok International Ltd wishes to announce the resignations of Messrs Damien Seah Yang Hwee and Fong Nien Song as Directors of the Company with effect from 20 April 2004. With Messrs Seah and Fong's resignation as Directors, they ceased to be members of the Audit Committee. Their replacements will be announced in due course. Submitted by Phua Puay Heng, Group Financial Controller on 26/04/2004 to the SGX. LIVONIA INVESTMENTS: Creditors Must Submit Claims by May 21 ----------------------------------------------------------- Notice is hereby given that the creditors of Livonia Investments Pte Ltd., whose debts or claims have not already been admitted, are required on or before 21 May 2004 to submit particulars of their debts or claims and any security held by them to the liquidator at its address a formal Proof of Debt in accordance with Form 77 containing their respective debts or claims. In default of complying with this notice they will be excluded from the benefit of any distribution made before their debts or claims are proved or their priority is established and from objecting to the distribution. Lim Say Wan Liquidator. C/- 6 Shenton Way #32-00 DBS Building Tower Two Singapore 068809. This Singapore Government Gazette announcement is dated 23 April 2004. MURRANNE PTE: Issues Debt Claim Notice to Creditors Notice is hereby given that the creditors of Murranne (Holdings) Pte Ltd (In Members' Voluntary Liquidation), whose debts or claims have not already been admitted, are required on or before 21 May 2004 to submit the particulars of their debts or claims and any security held by them to the liquidator at its address a formal proof of debt in accordance with Form 77 containing their respective debts or claims. In default of complying with this notice they will be excluded from the benefit of any distribution made before their debts or claims are proved or their priority is established and from objecting to the distribution. Lim Say Wan Liquidator. C/- 6 Shenton Way #32-00 DBS Building Tower Two Singapore 068809. This Singapore Government Gazette announcement is dated 23 April 2004. PERTAMA DEVELOPMENT: Issues Winding Up Order Notice Pertama Development Pte Ltd. issued a notice of winding up order made on the 16 April 2004. Name and Address of Liquidator: The Official Receiver Insolvency & Public Trustee's Office The URA Centre (East Wing) 45 Maxwell Road #06-11 Singapore 069118. Leong Kwok Yan Solicitor for the Petitioner. Note: (a) All creditors of the company should file their proof of debt with the liquidator who will be administering all affairs of the company. (b) All debts due to the company should be forwarded to the liquidator. This Singapore Government Gazette announcement is dated 23 April 2004. ********* S U B S C R I P T I O N  I N F O R M A T I O N Troubled Company Reporter -- Asia Pacific is a daily newsletter co-published by Bankruptcy Creditors' Service, Inc., Trenton, NJ USA, and Beard Group, Inc., Frederick, Maryland USA. Lyndsey Resnick, Ma. Cristina Pernites-Lao, Faith Marie Bacatan, Editors. *** End of Transmission ***
http://bankrupt.com/TCRAP_Public/040428.mbx
Citation Nr: 1534091 Decision Date: 08/10/15 Archive Date: 08/20/15 DOCKET NO. 00-09 843 ) DATE ) ) On appeal from the Department of Veterans Affairs Regional Office in Buffalo, New York THE ISSUES 1. Entitlement to service connection for a skin disability of the hands. 2. Entitlement to service connection for kidney cancer, to include as due to herbicide exposure. 3. Entitlement to an initial rating in excess of 10 percent for a left knee disability. 4. Entitlement to an initial rating in excess of 10 percent for a right knee disability. 5. Entitlement to an initial compensable rating for fasciculations of the face. 6. Entitlement to an initial compensable rating for fasciculations of the neck. 7. Entitlement to a total disability rating based upon individual unemployability as a result of service-connected disabilities (TDIU). REPRESENTATION Appellant represented by: Disabled American Veterans WITNESS AT HEARING ON APPEAL Veteran ATTORNEY FOR THE BOARD M. Mills, Associate Counsel INTRODUCTION The Veteran served on active duty from October 1966 to September 1970 and from December 1990 to September 1991. These matters come to the Board of Veterans' Appeals (Board) on appeal from rating decisions dated in February 2004 and August 2010 by the Department of Veterans Affairs (VA) Regional Office (RO) in Buffalo, New York. The Veteran provided testimony at a May 2015 hearing before the undersigned Veterans Law Judge. A transcript of the hearing is of record. The issues of entitlement to service connection for non-Hodgkin's lymphoma, arterial fibulation or flutter, and bone cancer have been raised by the record in March 2014 and May 2015 statements, but have not been adjudicated by the Agency of Original Jurisdiction (AOJ). Therefore, the Board does not have jurisdiction over those issues, and they are referred to the AOJ for appropriate action. 38 C.F.R. ง 19.9(b) (2014). The issue of entitlement to service connection for kidney cancer is REMANDED to the AOJ. FINDINGS OF FACT 1. During a May 2015 hearing, the Veteran requested a withdrawal of the appeal of the claim for service connection for a TDIU. 2. The competent medical evidence of records shows that it is at least as likely as not that a skin disability of the hands, diagnosed as orf, is related to active service. 3. The Veteran's left knee disability is manifested by painful motion and limitation of flexion to at most 100 degrees. 4. The Veteran's right knee disability is manifested by painful motion and limitation of flexion to at most 130 degrees. 5. From June 26, 2009, the Veteran's fasciculations of the face were manifested by no more than moderate disability. 6. From June 26, 2009, the Veteran's fasciculations of the neck were manifested by no more than moderate disability. CONCLUSIONS OF LAW 1. The criteria for withdrawal of an appeal by the Veteran of the claim for a TDIU are met. 38 U.S.C.A. ง 7105 (West 2014); 38 C.F.R. ง 20.204 (2014). 2. Resolving all reasonable doubt in favor of the Veteran, the criteria for service connection for a skin disability of the hands are met. 38 U.S.C.A. งง 1110, 1131, 5107 (West 2014); 38 C.F.R. งง 3.102, 3.159, 3.303 (2014). 3. The criteria for a disability rating in excess of 10 percent for a left knee disability are not met. 38 U.S.C.A. ง 1155, 5107 (West 2014); 38 C.F.R. งง 3.159, 4.1, 4.7, 4.10, 4.40, 4.45, 4.59, 4.71a, Diagnostic Code 5260 (2014). 4. The criteria for a disability rating in excess of 10 percent for a right knee disability are not met. 38 U.S.C.A. ง 1155, 5107 (West 2014); 38 C.F.R. งง 3.159, 4.1, 4.7, 4.10, 4.40, 4.45, 4.59, 4.71a, Diagnostic Code 5260 (2014). 5. Resolving all reasonable doubt in favor of the Veteran, from June 26, 2009, but not earlier, the criteria for a 10 percent rating for fasciculations of the face have been met. 38 U.S.C.A. งง 1155, 5107 (West 2014); 38 C.F.R. งง 3.102, 3.159, 4.1, 4.3, 4.20, 4.27, 4.124a, Diagnostic Code 8103 (2014). 6. Resolving all reasonable doubt in favor of the Veteran, from June 26, 2009, but not earlier, the criteria for a 10 percent rating for fasciculations of the neck, have been met. 38 U.S.C.A. งง 1155, 5107 (West 2014); 38 C.F.R. งง 3.102, 3.159, 4.1, 4.3, 4.20, 4.27, 4.124a, Diagnostic Code 8103 (2014). REASONS AND BASES FOR FINDINGS AND CONCLUSIONS Withdrawal The Board may dismiss any appeal which fails to allege specific error of fact or law in the determination being appealed. 38 U.S.C.A. ง 7105 (West 2014). A substantive appeal may be withdrawn on the record during a hearing, and at any time before the Board promulgates a decision. 38 C.F.R. งง 20.202, 20.204 (2014). Withdrawal may be made by the Veteran or the authorized representative. 38 C.F.R. ง 20.204 (2014). On the record during a March 2015 hearing, the Veteran requested withdrawal of the appeal of the claim for TDIU. Therefore, there remain no allegations of errors of fact or law for appellate consideration with respect to this claim. Thus, the Board does not have jurisdiction to review the appeal as to that claim, and it must be dismissed. Duties to Notify and Assist Upon receipt of a substantially complete application, VA must notify the claimant and any representative of any information, medical evidence, or lay evidence not previously provided to VA that is necessary to substantiate the claim. The notice must: (1) inform the claimant about the information and evidence not of record that is necessary to substantiate the claim; (2) inform the claimant about the information and evidence that VA will seek to provide; and (3) inform the claimant about the information and evidence the claimant is expected to provide. 38 U.S.C.A. งง 5103, 5103A, 5107 (West 2014); 38 C.F.R. ง 3.159 (2014); Pelegrini v. Principi, 18 Vet. App. 112 (2004). If VA does not provide adequate notice of any of element necessary to substantiate the claim, or there is any deficiency in the timing of the notice, the burden is on the claimant to show that prejudice resulted from any notice error. Shinseki v. Sanders, 129 S.Ct. 1696 (2009). The Board finds that any defect with regard to the timing or content of the notice to the appellant is harmless because of the thorough and informative notices provided throughout the adjudication and because the appellant had a meaningful opportunity to participate effectively in the processing of the claim with an adjudication of the claim by the RO subsequent to receipt of the required notice. The record does not show prejudice to the appellant, and the Board finds that any defect in the timing or content of the notices has not affected the fairness of the adjudication. Mayfield v. Nicholson, 19 Vet. App. 103 (2005); Dingess v. Nicholson, 19 Vet. App. 473 (2006). Specifically, the Veteran was notified in letters dated July 2003, March 2006, April 2009, February 2010, and August 2010. The Veteran has neither alleged nor demonstrated any prejudice with regard to the content or timing of the notice provided. Shinseki v. Sanders, 129 S. Ct. 1696 (2009) (burden of showing an error is harmful or prejudicial falls on party attacking agency decision); Mayfield v. Nicholson, 444 F.3d 1328 (Fed. Cir. 2006). The Board considers it significant that the subsequent statements made by the Veteran and representative suggest actual knowledge of the elements necessary to substantiate the claim. Dalton v. Nicholson, 21 Vet. App. 23 (2007) (actual knowledge is established by statements or actions by claimant or representative that demonstrate awareness of what is necessary to substantiate claim). Thus, VA has satisfied the duty to notify the appellant and had satisfied that duty prior to the adjudication in the September 2013 supplemental statement of the case. Overton v. Nicholson, 20 Vet. App. 427 (2006) (Veteran afforded a meaningful opportunity to participate effectively in adjudication of claim, and therefore notice error was harmless). The Board also finds that the duty to assist requirements have been fulfilled. All relevant, identified, and available evidence has been obtained, and VA has notified the appellant of any evidence that could not be obtained. The appellant has not referred to any additional, unobtained, relevant, available evidence. VA has obtained an examination with respect to the claims. Thus, the Board finds that VA has satisfied the duty to assist. No further notice or assistance to the Veteran is required to fulfill VA's duty to assist in development. Smith v. Gober, 14 Vet. App. 227 (2000); Dela Cruz v. Principi, 15 Vet. App. 143 (2001); Quartuccio v. Principi, 16 Vet. App. 183 (2002). Service Connection Service connection may be granted for a disability resulting from disease or injury incurred in or aggravated by active service. 38 U.S.C.A. งง 1110, 1131 (West 2014). To establish service connection for a disability, a Veteran must show: (1) the existence of a present disability; (2) in-service incurrence or aggravation of a disease or injury; and (3) a causal relationship between the present disability and the disease or injury incurred or aggravated during service. Shedden v. Principi, 381 F.3d 1163 (Fed. Cir. 2004). The absence of any one element will result in denial of service connection. Coburn v. Nicholson, 19 Vet. App. 427 (2006). When a claimant seeks benefits and the evidence for and against the claim is in relative equipoise, the claimant prevails. 38 U.S.C.A. ง 5107 (West 2014); 38 C.F.R. ง 3.102 (2014); Gilbert v. Derwinski, 1 Vet. App. 49 (1990). The preponderance of the evidence must be against a claim for the claim to be denied. Alemany v. Brown, 9 Vet. App. 518 (1996). Skin Disability of the Hands The Veteran contends that during service in Southwest Asia that he lived in an area that had been formerly used for raising sheep by sheep herders. He contends the conditions were unsanitary and that he was exposed to sheep feces and open sewers. He submitted three buddy statements in support of those contentions. In an October 2003 statement, R.M. noted the unsanitary conditions at locations such as Griffin Base from around January 1991 to May 1991. R.M. stated that he and the Veteran lived in facilities where sheep were herded and fed before slaughtering. R.M. contended that they had to live in tents during the compound clean-up. In an October 2003 statement, J. E. indicated that Griffin Base was a former fattening station for sheep before they were sent to market, and that across from the base was a facility for mixing barley into sheep food. J.E. stated that the conditions were very unsanitary, and that the Veteran served in the locations from around January 1991 to June 1991. In a September 2004 statement, R.D. noted that during service with the Veteran in Saudi Arabia from around January 1991 to September 1991, that they lived at various locations where sheep and goats were kept. They lived, worked, ate, and slept in those locations, which included Griffin Base and Khobar Towers. The areas were filthy and required extensive cleaning. The Veteran also submitted copies of a personal journal kept during this service, in which he commented about the unsanitary living conditions. He also submitted photographs of Kuwait and Saudi Arabia showing camels and presumably the inside of a compound. The Board finds the Veteran's reports of in-service exposure to sheep and animal byproducts to be competent and consistent with his service record and the lay statements of record. Moreover, the Board finds the lay evidence submitted to show exposure to sheep as credible for the purposes of this decision. In a June 2000 pathology report, T.N., Helm, M.D, a private physician with certification in dermatopathology, shows the Veteran sought treatment for nodules on his fingers. The specimens were excised and examined. Dr. Helm determined the biopsy was consistent with the differential diagnoses of orf and milkers' nodule. However because of the full thickness necrosis, a diagnosis of orf was rendered. In a July 2000 letter, Dr. Wirth, a private dermatologist, stated orf is a viral inoculation of the skin usually obtained from sheep. Dr. Wirth indicated the Veteran had no previous exposure to livestock prior to his visit to the Middle East, which was likely causal for his development of orf. In a September 2000 letter, C. Brass, M.D., a private infectious disease physician, indicated that the Veteran had histologic evidence of orf. On VA examination in October 2003, the examiner opined that the Veteran had dyshidrotic eczema. The examined opined that the diagnosis of orf would be unlikely because usually with orf, a patient gets a lesion once and then develops an immune response to it. The examiner noted that while the Veteran had indirect contact with sheep, there was no direct contact. The examiner also opined that the skin lesions did not resemble orf as shown in textbooks. The examiner further noted that orf would have developed earlier than it did in the Veteran, and that there was no documentation of a rash in service. Finally, the examiner found that dyshidrosis was a more plausible diagnosis. A November 2003 VA treatment record shows the Veteran sought treatment for urticaria, or hives. The assessment was idiopathic urticaria, the only association was orf, and pox virus chronic and recurring since first Gulf War. The record noted orf was diagnosed at VA multiple times. In a March 2005 letter, Dr. Wirth stated that the Veteran's diagnosis of orf was based on clinical and histologic findings. Dr. Wirth noted that the possibly of antibodies forming was possible, but stated he could not comment on a diagnosis of dyshidrotic eczema as he only saw the Veteran for the hand nodules. In a July 2007 letter, Dr. Wirth stated it was at least likely as not that the Veteran's skin condition developed in the Middle East. On review of the record, including literature submitted by the Veteran, orf is an infection caused by a member of the parapoxvirus genus of the poxvirus family. It is endemic in Africa, the Middle East, the Indian subcontinent, and much of Asia. It is rarely seen in North America. It is a disease widespread in sheep and goats, and can be transmitted to humans through contact with infected animals, carcasses, or contaminated nonliving material such as fences, barn doors, feeding troughs, or shears. Orf normally affects the hands, fingers, or forearms. Resolving all reasonable doubt in favor of the Veteran, the Board finds that service connection is warranted for a skin disability of the hands, diagnosed as orf based on the favorable private medical opinions of record. The Board has given consideration to both the positive and negative evidence of record and finds that the overall evidence to be at least in relative equipoise on whether the Veteran has a skin disability of the hands that is at least as likely as not due to service. While the October 2003 VA opinion is unfavorable to the claim, the focus of the opinion was largely limited to determining whether the Veteran had a diagnosis of orf. Private examiners specializing in infectious disease and dermatopathology have diagnosed orf based on pathology reports. Furthermore, there are several opinions of record, which the Board finds to be credible and persuasive regarding the etiology of the Veteran's skin disability of the hands. When, after careful consideration of all procurable and assembled data, a reasonable doubt arises regarding service origin, the degree of disability, or any other point, the reasonable doubt will be resolved in favor of the claimant. 38 C.F.R. ง 3.102 (2014). Therefore, resolving all reasonable doubt in favor of the appellant, the Board finds that service connection is warranted for a skin disability of the hands, diagnosed as orf. 38 U.S.C.A. ง 5107(b) (West 2014); Gilbert v. Derwinski, 1 Vet. App. 49 (1990). Increased Ratings Disability ratings are based upon the average impairment of earning capacity as determined by a schedule for rating disabilities. 38 U.S.C.A. ง 1155 (West 2014); 38 C.F.R. Part 4 (2014). Separate rating codes identify the various disabilities. 38 C.F.R. Part 4 (2014). The determination of whether an increased rating is warranted is based on review of the entire evidence of record and the application of all pertinent regulations. Schafrath v. Derwinski, 1 Vet. App. 589 (1991). Where there is a question as to which of two ratings shall be applied, the higher rating will be assigned if the disability picture more nearly approximates the criteria for that rating. Otherwise, the lower rating will be assigned. 38 C.F.R. ง 4.7 (2014). The Board will consider entitlement to staged ratings to compensate for times since filing the claim when the disability may have been more severe than at other times during the course of the claim on appeal. Fenderson v. West, 12 Vet. App. 119 (1999); Hart v. Mansfield, 21 Vet. App. 505 (2007). When there is an approximate balance of positive and negative evidence regarding any issue material to the determination of a matter, VA shall resolve reasonable doubt in favor of the claimant. 38 U.S.C.A. ง 5107 (West 2014); Gilbert v. Derwinski, 1 Vet. App. 49 (1990). Right Knee and Left Knee Disabilities An August 2010 rating decision granted service connection for right and left knee disabilities effective March 13, 2009, under Diagnostic Code 5003-5260. Hyphenated diagnostic codes are used when a rating under one diagnostic code requires the use of an additional diagnostic code to identify the basis for the rating assigned; the additional code is shown after the hyphen. 38 C.F.R. ง 4.27 (2014). Under Diagnostic Code 5003, a rating of 10 percent is provided for degenerative arthritis of a major joint or group of minor joints that is established by x-ray findings with pain and noncompensable limitation of motion. A rating under Diagnostic Code 5003 cannot be combined with a rating based on limitation of motion. A 20 percent rating is warranted with incapacitating episodes. 38 C.F.R. ง 4.71a, Diagnostic Code 5003 (2014). Under Diagnostic Code 5260, limitation of flexion of the knee to 60 degrees warrants a 0 percent rating. Limitation of flexion to 45 degrees warrants a 10 percent rating. Limitation of flexion to 30 degrees warrants a 20 percent rating. Limitation of flexion to 15 degrees warrants a 30 percent rating. 38 C.F.R. ง 4.71a, Diagnostic Code 5260 (2014). The Schedule provides that the normal range of motion of the knee is 0 degrees of extension to 140 degrees of flexion. 38 C.F.R. ง 4.71, Plate II (2014). Separate ratings can be assigned for the same knee joint for limitation of extension, limitation of flexion, and recurrent subluxation or lateral instability. However, to assign a separate compensable rating, the criteria for a compensable rating must be met under both sets of criteria. VAOPGCPREC 9-98 (1998), 63 Fed. Reg. 56704 (1998); VAOGCPREC 23-97 (1997), 62 Fed. Reg. 63604 (1997). Other diagnostic codes relating to the knee are Diagnostic Code 5256 (ankylosis), Diagnostic Code 5257 (recurrent subluxation or lateral instability), Diagnostic Codes 5258 and 5259 (symptomatic dislocation and/or removal of semilunar cartilage), Diagnostic Code 5261 (limitation of extension), Diagnostic Code 5262 (impairment of tibia and fibula) and Diagnostic Code 5263 (genu recurvatum). 38 C.F.R. ง 4.71a (2014). In rating disabilities of the musculoskeletal system, additional rating factors include functional loss due to pain supported by adequate pathology and evidenced by the visible behavior of the claimant undertaking the motion. 38 C.F.R. ง 4.40 (2014). Inquiry must also be made as to weakened movement, excess fatigability, incoordination, and reduction of normal excursion of movements, including pain on movement. 38 C.F.R. ง 4.45 (2014). The intent of the schedule is to recognize painful motion with joint or periarticular pathology as productive of disability. It is the intention to recognize actually painful, unstable, or malaligned joints, due to healed injury, as entitled to at least the minimum compensable rating for the joint. 38 C.F.R. ง 4.59 (2014). When assigning a disability rating, it is necessary to consider functional loss due to flare-ups, fatigability, incoordination, and pain on motion. DeLuca v. Brown, 8 Vet. App. 202 (1995). A March 2009 VA treatment record noted abnormal gliding of the left knee patella with standing squat and in supine knee extension to knee flexion. Laxity was noted with testing of the medial structure of the knee. The Veteran reported increase in buckling of the knee resulting in falls. On VA examination in July 2009, the Veteran reported daily flare-ups of pain aggravated by bending, stooping, squatting, kneeling, climbing stairs, or moving heavy objects. He reported use of a cane primarily for the left knee. There was walking with a pronounced antalgic gait. Physical evaluation revealed that the left knee was slightly tender upon deep palpation of the anterior aspect. Flexion was 0 to 100 degrees with slight pain at 90 degrees and extension with no pain. Repetitive motion testing reduced flexion to 90 degrees due to pain and lack of endurance. The left knee was stable in terms of normal function of the medial and lateral collateral ligaments and the anterior and posterior cruciate ligaments. The right knee was normal on inspection and palpation. There was no effusion. Flexion was to 130 degrees with no pain. Extension was to 0 degrees with no pain. Repetitive motion testing revealed no changes in range of motion. The examiner noted the right knee was completely stable. There was x-ray evidence of degenerative joint disease of both knees. A June 2010 VA treatment record notes the Veteran reports falling a lot due to the left knee. He also reported the top part slid down the end. On VA examination in October 2010, the Veteran reported constant pain in the left knee with buckling all the time. He reported use of a cane to prevent buckling. He denied any locking. He reported lack of endurance after walking and needing to rest. There was no effusion of the knee. There was no history of swelling, heat, or redness associated with the knee. He reported use of a brace when it bothered him during a flare-up. He reported bi-weekly flare-ups with pain at a 10 out of 10 lasting for two to three hours. The Veteran denied any incapacitating episodes. Functional assessment revealed he could walk 60 feet and stand 5 to 10 minutes. He denied any knee prosthesis. Left knee range of motioned testing revealed flexion to 120 degrees with pain at 110 degrees and extension to 5 degrees. Repetitive motion testing revealed no change in range of motion or increase pain or worsening of fatigue or lack of endurance. For the right knee, the Veteran reported pain at a constant 8 out of 10. He denied buckling. There was no locking, heat, redness, tenderness, or drainage. He denied any flare-ups of the right knee. Physical examination revealed right knee flexion to 140 degrees and extension to 0 degrees, with no pain. Repetitive range of motion testing revealed no change in range of motion or increased pain or worsening of fatigue or lack of endurance. There was no motion for the medial and lateral stress and anterior and posterior stress stability tests. McMurray test was negative. A December 2010 internal medicine examination, part of the Veteran's Social Security Administration records, noted knee flexion to 120 degrees bilaterally. There were no evidence subluxations, contractures, or ankylosis. There was mild thickening of both knees. The joints were stable and nontender. There was no redness, heat, swelling, or effusion. The examiner noted mild limitation in kneeling and climbing due to knee pain. During the May 2015 hearing, the Veteran reported additional functional loss with flare-ups of pain for the knees. He reported stiffening, locking, and popping. He reported use of a cane and braces for the knees. He indicated that the left knee was worse than the right knee and reported 15 to 20 falls during the previous year. In regard to falls, the Veteran indicated that he moved the furniture in his home to catch himself to prevent falls. The Board finds that the Veteran is not entitled to a rating in excess of 10 percent for the either knee disability based on limitation of motion. There is no evidence of record indicating that he had limitation of flexion to 30 degrees or less to warrant a higher 20 percent rating, even considering the range of motion after repetitive testing and any additional loss of function due to pain or other factors. In fact, while the Veteran reported pain on motion, his left knee flexion was limited to at worst 90 degrees after repetitive motion testing. The Board finds that the knee disabilities are consistent with the assigned 10 percent rating. The Board reaches the same conclusion even when considering functional loss due to pain. 38 C.F.R. งง 4.40, 4.45, 4.59 (2014); DeLuca v. Brown, 8 Vet. App. 202 (1995). The Board finds that the 10 percent ratings adequately compensates the Veteran for any pain, tenderness, weakness, and incoordination associated with the service-connected knee disabilities, and none of the findings have been shown to be so disabling as to, effectively, result in ankylosis as required for a higher rating under Diagnostic Code 5256. 38 C.F.R. ง 4.71a (2014). While the VA examiners noted pain on range of motion, the maximum ranges of motion were not reduced on repetitive motion testing and are the most persuasive measure of remaining functional capacity of the knees. Moreover, the Veteran is not entitled to a higher evaluation under Diagnostic Code 5003. The Board also notes that at no time was extension of either knee limited to 10 degrees to warrant a separate compensable rating, even when considering any additional loss of motion due to pain and other factors. 38 C.F.R. ง 4.71a, Diagnostic Code5261 (2014). The examinations have never shown limitation of extension to 10 degrees. Furthermore, because the 10 percent ratings assigned are based on limitation of motion, they cannot be combined with ratings based on arthritis of a major joint. In addition, incapacitating episodes are not shown. 38 C.F.R. ง 4.71a, Diagnostic Codes 5003, 5010 (2014). The evidence also did not show instability such that any separate compensable rating could be assigned under Diagnostic Code 5257. 38 C.F.R. ง 4.71a (2014). Although the Veteran reported use of a cane and buckling in the left knee and laxity was noted in the March 2009 VA treatment record, objective stability tests on VA examination in July 2009 and October 2010 were normal. There were no medical or lay reports of subluxation or dislocation. Furthermore, the Veteran's left knee complaints of stiffening, popping, and buckling are considered in the 10 percent rating for limitation of motion. Therefore, the Board finds that a separate rating under Diagnostic Code 5258 for either knee is not warranted. 38 C.F.R. ง 4.71a (2014). The preponderance of the evidence is against a finding that slight recurrent lateral instability or subluxation is present. Consideration has been given to assigning a separate rating for the right knee or the left knee, under Diagnostic Code 5259. However, the Board notes that there is no evidence that the Veteran has or had cartilage removed from either knee. Therefore, a separate rating under Diagnostic Code 5259 is not warranted for either knee. 38 C.F.R. ง 4.71a (2014). The evidence does not show that any separate compensable rating could be assigned for limitation of extension as extension was to 0 degrees on the VA examinations for the right knee and to at worst, 5 degrees for the left knee on VA examination in October 2010. Limitation of extension to 10 degrees that would warrant a compensable rating is not shown for either knee. 38 C.F.R. ง 4.71a, Diagnostic Code 5261 (2014). There is no evidence of tibia or fibula impairment to warrant a separate compensable rating under Diagnostic Code 5262. 38 C.F.R. ง 4.71a, Diagnostic Codes 5262 (2014). Consideration has been given to assigning a separate rating for the right knee or left knee, under Diagnostic Code 5263. However, the Board notes that there is no objective evidence of genu recurvatum in either knee. Therefore, a separate rating under Diagnostic Code 5263 is not warranted for either knee. 38 C.F.R. ง 4.71a (2014). Consideration has been given to assigning staged ratings. However, at no time during the period in question has the disability warranted higher schedular ratings than those assigned. Fenderson v. West, 12 Vet. App. 119 (1999); Hart v. Mansfield, 21 Vet. App. 505 (2007). The Board has also considered whether this case should be referred to the Director of the VA Compensation and Pension Service for consideration of the assignment of an extra-schedular rating. 38 C.F.R. ง 3.321(b)(1) (2014). The first step is to determine whether the evidence before VA presents such an exceptional disability picture that the available schedular ratings for that service-connected disability are inadequate. Thun v. Peake, 22 Vet. App. 111 (2008). Therefore, initially, there must be a comparison between the level of severity and the symptomatology of the claimant's disability with the established criteria provided in the rating schedule for the disability. In this case, the rating criteria for the musculoskeletal system reasonably describe the Veteran's disability level and symptomatology, and provide for consideration of greater disability and symptoms than currently shown by the evidence. The evidence does not show anything unusual or exceptional that would make the schedular criteria inadequate in this case. In the case at hand, the record shows that the manifestations of the Veteran's knee disabilities are contemplated by the schedular criteria. There is no indication that the average industrial impairment from the knee disabilities is in excess of that contemplated by the assigned rating. A higher rating is available for more severe levels of impairment, but the Veteran does not meet the criteria for the higher rating based on the demonstrated range of motion. The evidence also does not show marked interference with employment or frequent hospitalization. Therefore, the Board finds that referral for extra-schedular consideration is not warranted. Accordingly, the Board finds that the criteria for initial 10 percent ratings for the right and left knee disabilities were met from March 13, 2009, and the preponderance of the evidence is against the assignment of any higher rating. 38 U.S.C.A. ง 5107(b) (West 2014); Gilbert v. Derwinski, 1 Vet. App. 49 (1990). Fasciculations of the Face and Neck An August 2010 rating decision granted service connection for benign fasciculations of the neck and face with a 0 percent rating effective June 26, 2009, under Diagnostic Codes 5325-8103. 38 C.F.R. ง 4.27 (2014). Under Diagnostic Code 5325 (muscle injury, facial muscles), functional impairment is rated as seventh (facial) cranial nerve neuropathy (Diagnostic Code 8207), disfiguring scar (Diagnostic Code 7800), etc. Minimum, if interfering to any extent with mastication is 10 percent. Under Diagnostic Code 8103 (tic, convulsive), mild disability warrants a 0 percent rating, moderate disability warrants a 10 percent rating, and a severe disability warrants a 30 percent rating. A note indicates rating depending upon frequency, severity, and muscle groups involved. Under Diagnostic Code 8207 (paralysis of seventh (facial) cranial nerve), incomplete, moderate paralysis warrants a 10 percent rating, incomplete, severe paralysis warrants a 20 percent rating, and complete paralysis warrants a 30 percent rating. A note indicates these ratings are dependent upon relative loss of innervation of facial muscles. 38 C.F.R. ง 4.124a, Diagnostic Code 8207, Note. A September 2011 VA EMG revealed an abnormal study. There was electrophysiologic evidence of mild ulnar neuropathy at the left elbow. In addition, the presence of frequent fasciculation potentials in the absence of ongoing denervation or chronic reinnervation suggests a benign fasciculation syndrome. In a September 2009 letter, C.M. Deakin, M.D. indicated that during an August 2009 evaluation, the Veteran reported intermittent muscle fasciculations that impaired his ability to function and led to chronic insomnia, depression, and anxiety. Later that month, the Veteran reported diminished fasciculations due to medication. On VA examination in May 2010, the Veteran reported persistent fasciculations in the neck and face that were worse at rest and night resulting in difficulty sleeping. Physical examination of the facial and neck muscles revealed fasciculations. Muscles showed normal power, tone, and bulk. There was no atrophy or deformity noted. Pupils were equal and reactive to light and accommodation. Extraocular movements were intact. Facial sensation was intact in all three distributions in the trigeminal nerve. Cranial reflexes were normal bilaterally, and muscles on mastication were intact. Muscles for facial expression were intact and symmetric. Cranial nerve 9 showed normal reflexes. The examiner diagnosed benign fasciculations involving the face and neck. In a September 2012 statement, N. Silvestri, M.D. indicated that the muscle twitching the Veteran experienced in his face and neck was due to the same condition causing it in his arms and legs, benign fasciculation syndrome. In the May 2015 Board hearing, the Veteran reported daily fasciculations of the face and neck lasting from 20 minutes to 10 hours. He indicated that it was more active during eating and sleeping affecting the entire neck and face. He stated that the jaw area was most affected. Resolving all reasonable doubt in favor of the Veteran, the Board finds separate 10 percent ratings are warranted for the fasciculations of the face and neck, effective June 26, 2009, the date of service connection. The Veteran has consistently reported fasciculations during the appeal of varying degree. A private examiner noted in September 2009 that the Veteran initially reported intermittent fasciculations that diminished due to medication. Then, on VA examination in May 2010, the Veteran reported persistent fasciculations worse at rest and during the nighttime. During the May 2015 Board hearing, the Veteran reported daily fasciculations lasting varying lengths of time. When considering the frequency, severity, and location of the fasciculations of the face and neck, the Board finds the fasciculations of the face and neck are no more than a moderate disability which is consistent with a 10 percent rating under Diagnostic Code 8103 (tic, convulsive). The Board finds that the Veteran is not entitled to a rating in excess of 10 percent for the fasciculations of the face and neck. Given the absence of constant fasciculations of the face and neck, the Veteran's disabilities cannot be better characterized as severe disability to warrant a higher rating under Diagnostic Code 8103. The Board has considered other relevant diagnostic codes. There is no evidence of interference with mastication to warrant a 10 percent rating under Diagnostic Code 5325. There is no evidence of paralysis of the seventh cranial nerve to warrant a higher rating based on loss of innervation of facial muscles under Diagnostic Code 8207. Consideration has been given to assigning staged ratings. However, at no time during the period in question has the disability warranted higher schedular ratings than those assigned. Fenderson v. West, 12 Vet. App. 119 (1999); Hart v. Mansfield, 21 Vet. App. 505 (2007). The Board has also considered whether this case should be referred to the Director of the VA Compensation and Pension Service for consideration of the assignment of an extra-schedular rating for all the time periods under consideration. 38 C.F.R. ง 3.321(b)(1) (2014). The first step is to determine whether the evidence before VA presents such an exceptional disability picture that the available schedular ratings for that service-connected disability are inadequate. Thun v. Peake, 22 Vet. App. 111 (2008). Therefore, initially, there must be a comparison between the level of severity and the symptomatology of the claimant's disability with the established criteria provided in the rating schedule for the disability. In this case, the rating criteria for the fasciculations of the face and neck reasonably describe the Veteran's disability level and symptomatology, and provide for consideration of greater disability and symptoms than currently shown by the evidence. The assigned rating considers the severity, frequency, and location of the Veteran's disability. The evidence does not show anything unusual or exceptional that would make the schedular criteria inadequate in this case. The evidence does not show marked interference with employment or frequent hospitalization. Moreover, a higher rating is available for more severe levels of impairment, but the Veteran does not meet the criteria for the higher rating based on reported symptomatology. Accordingly, the Board finds that a 10 percent rating, but not higher, is warranted for fasciculations of the face and neck as of June 26, 2009. However, the preponderance of the evidence is against the assignment of a rating higher than 10 percent for fasciculations of the face and neck. 38 U.S.C.A. ง 5107(b); Gilbert v, Derwinksi, 1 Vet. App. 49 (1990). ORDER Service connection for a skin disability of the hands is granted. An initial rating in excess of 10 percent for a left knee disability is denied. An initial rating in excess of 10 percent for a right knee disability is denied. A 10 percent rating, but not higher, from June 26, 2009, for fasciculations of the face, is granted. A 10 percent rating, but not higher, from June 26, 2009, for fasciculations of the neck, is granted. The appeal of entitlement to TDIU is dismissed. REMAND A September 2014 rating decision denied service connection for kidney cancer. In September 2014, the Veteran submitted a notice of disagreement with that decision. A review of the record shows that the Veteran has not been issued a statement of the case in response to that notice of disagreement. Therefore, the appropriate Board action is to remand that issue for issuance of a statement of the case. Manlincon v. West, 12 Vet. App. 238 (1999). Accordingly, the case is REMANDED for the following action: Issue a statement of the case which addresses the issue of entitlement to service connection for kidney cancer, to include as due to herbicide exposure. Inform the Veteran of his appeal rights and that he must file a timely substantive appeal if he desires appellate review. If the Veteran perfects an appeal, return the case to the Board. The Veteran has the right to submit additional evidence and argument on the matter the Board has remanded. Kutscherousky v. West, 12 Vet. App. 369 (1999). This claim must be afforded expeditious treatment. The law requires that all claims that are remanded by the Board or the United States Court of Appeals for Veterans Claims for additional development or other appropriate action must be handled in an expeditious manner. 38 U.S.C.A. งง 5109B, 7112 (West 2014). ______________________________________________ Harvey P. Roberts Veterans Law Judge, Board of Veterans' Appeals Department of Veterans Affairs
https://www.va.gov/vetapp15/Files4/1534091.txt
IJERPH | Free Full-Text | ZanzaMapp: A Scalable Citizen Science Tool to Monitor Perception of Mosquito Abundance and Nuisance in Italy and Beyond Mosquitoes represent a considerable nuisance and are actual/potential vectors of human diseases in Europe. Costly and labour-intensive entomological monitoring is needed to correct planning of interventions aimed at reducing nuisance and the risk of pathogen transmission. The widespread availability of mobile phones and of massive Internet connections opens the way to the contribution of citizen in complementing entomological monitoring. ZanzaMapp is the first mobile & ldquo;mosquito& rdquo; application for smartphones specifically designed to assess citizens& rsquo; perception of mosquito abundance and nuisance in Italy. Differently from other applications targeting mosquitoes, ZanzaMapp prioritizes the number of records over their scientific authentication by requesting users to answer four simple questions on perceived mosquito presence/abundance/nuisance and geo-localizing the records. The paper analyses 36,867 ZanzaMapp records sent by 13,669 devices from 2016 to 2018 and discusses the results with reference to either citizens& rsquo; exploitation and appreciation of the app and to the consistency of the results obtained with the known biology of main mosquito species in Italy. In addition, we provide a first small-scale validation of ZanzaMapp data as predictors of Aedes albopictus biting females and examples of spatial analyses and maps which could be exploited by public institutions and administrations involved in mosquito and mosquito-borne pathogen monitoring and control. ZanzaMapp: A Scalable Citizen Science Tool to Monitor Perception of Mosquito Abundance and Nuisance in Italy and Beyond by Beniamino Caputo 1,† , Mattia Manica 1,2,† , Federico Filipponi 3 , Marta Blangiardo 4 , Pietro Cobre 1 , Luca Delucchi 2 , Carlo Maria De Marco 1 , Luca Iesu 5 , Paola Morano 6 , Valeria Petrella 5 , Marco Salvemini 5 , Cesare Bianchi 6 and Alessandra della Torre 1,* 1 Department of Public Health & Infectious Diseases, Laboratory affiliated to Istituto Pasteur Italia—Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy 2 Department of Biodiversity and Molecular Ecology, Research and Innovation Centre, Fondazione Edmund Mach, 38010 San Michele all’Adige, Italy 3 Institute for Environmental Protection and Research (ISPRA), via Vitaliano Brancati 48, 00144 Roma, Italy 4 MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London W2 1PG, UK 5 Department of Biology, University of Naples Federico II, 80126 Naples, Italy 6 GH s.r.l., via Petralia Sottana, 11, 00132 Rome, Italy * Author to whom correspondence should be addressed. Int. J. Environ. Res. Public Health 2020 , 17 (21), 7872; https://doi.org/10.3390/ijerph17217872 (This article belongs to the Special Issue Ecology, Epidemiology, Surveillance, and Control of Vectors and Vector-Borne Pathogens in Temperate Regions ) Abstract Mosquitoes represent a considerable nuisance and are actual/potential vectors of human diseases in Europe. Costly and labour-intensive entomological monitoring is needed to correct planning of interventions aimed at reducing nuisance and the risk of pathogen transmission. The widespread availability of mobile phones and of massive Internet connections opens the way to the contribution of citizen in complementing entomological monitoring. ZanzaMapp is the first mobile “mosquito” application for smartphones specifically designed to assess citizens’ perception of mosquito abundance and nuisance in Italy. Differently from other applications targeting mosquitoes, ZanzaMapp prioritizes the number of records over their scientific authentication by requesting users to answer four simple questions on perceived mosquito presence/abundance/nuisance and geo-localizing the records. The paper analyses 36,867 ZanzaMapp records sent by 13,669 devices from 2016 to 2018 and discusses the results with reference to either citizens’ exploitation and appreciation of the app and to the consistency of the results obtained with the known biology of main mosquito species in Italy. In addition, we provide a first small-scale validation of ZanzaMapp data as predictors of Aedes albopictus biting females and examples of spatial analyses and maps which could be exploited by public institutions and administrations involved in mosquito and mosquito-borne pathogen monitoring and control. Keywords: citizen science ; mosquito ; nuisance ; biting activity ; tiger mosquito ; Aedes albopictus 1. Introduction Mosquitoes are among the deadliest animals worldwide due to their capacity to transmit pathogens (e.g., malaria parasites and arboviruses, such as yellow fever, dengue and Zika) affecting hundreds of million people and causing more than 700,000 deaths/year, primarily in tropical regions. As vaccines for most mosquito-borne diseases are not yet available, the prevention of this huge burden to human health largely focuses on tackling the mosquito vectors, primarily through large-scale insecticide-based interventions at country/regional level, with very high costs on a global scale. In temperate regions, however, mosquitoes are mostly perceived as a nuisance, in spite of the fact that mosquito-borne viruses, such as the West Nile virus, are endemic in several European and North American Countries. Moreover, the colonization of these regions by invasive species (typically belonging to the genus Aedes ), ongoing since the eighties, has led to several cases of autochthonous transmission of exotic arboviruses such as dengue in Europe and USA [ 1 , 2 ], Zika in the USA [ 3 ], and to two chikungunya outbreaks with hundred human infections in Italy [ 4 ]. Differently from mosquito control interventions aimed at preventing disease transmission in tropical areas, interventions for nuisance (and risk of pathogen transmission) reduction purposes in temperate regions are rarely organized at country/regional level and largely implemented by private pest control companies appointed either by municipalities to treat public areas or by citizen to treat private ones. In both cases, the foundations for the planning of appropriate control plans lie on a good knowledge of the mosquito species behavior, spatial distribution and temporal dynamics, as well as on a constant assessment of the field-efficacy of the implemented control measures [ 5 , 6 , 7 ]. Indeed, large-scale implementation of surveillance and monitoring activities is very challenging and costly, posing serious constraints to both the optimization of control plans and to the assessment of the risk and dynamics of pathogen transmission [ 8 ], particularly in temperate regions where public health threats and available resources are limited. The extensive availability of mobile phones and of Internet connections opens the way to the contribution of the citizenry in solving/minimizing this problem [ 9 ]. Indeed, in recent years, citizen science data have been reliably exploited for wildlife surveys by successfully linking citizens to academics and produced very relevant outputs [ 10 ]. In Europe, citizen science projects exploiting data from mobile phone applications have been proposed to complement mosquito surveillance in several countries [ 11 ]. In the Netherlands, Muggenradar has been used as an effective method to clarify the distribution of the biotypes of the night biting urban mosquito— Culex pipiens —thanks to the physical collection (by citizen) and identification (by scientists) of specimens from all over the country [ 12 ]. In Germany, Mückenatlas has allowed detection of changes in the country mosquito fauna, again based on samples collected from the citizens and mailed to specialists [ 13 ]. In Spain, Mosquito Alert has provided a comprehensive picture of the ongoing invasion of the country by the Asian tiger mosquito ( Aedes albopictus ) [ 9 ]; it also provided the first record of a second invasive species, Aedes japonicus [ 14 ], and revealed a clear pattern of passive dispersal by cars [ 15 ], thanks to photos sent by citizens to a specialist entomology team. ZanzaMapp (manufacturer, city, country) is the first mobile “mosquito” application for smartphones specifically designed to contribute to the assessment of the perception of mosquito abundance and nuisance in Italy. Differently from the other applications mentioned above, ZanzaMapp prioritizes the number of records to their authentication. For this reason, ZanzaMapp 1.1.1 (GH s.r.l., Rome Italy) was designed to require the least possible effort and to offer the smoothest experience to users, who were not asked to send mosquito photos or samples, but only to fill an easy and quick questionnaire. We envisaged that an app with these characteristics could provide valuable data on mosquito spatial and temporal dynamics both on a large-scale (e.g., to build information-based models on the risk of arbovirus transmission) and on a local-scale (e.g., to identify spatio-temporal hot-spots of mosquito abundance on which to focus control interventions or to assess the effectiveness of the interventions), as well as a significant contribution to the education of citizens on mosquito prevention and control. Indeed, both ZanzaMapp and the associated website provide easy access to scientifically validated information on basic mosquito morphology and bionomics, on the pathogens they transmit, and on control methods and personal protection measures. The present paper analyses ZanzaMapp data obtained from 2016 to 2018 and discusses the results with reference to the exploitation and appreciation of the app by citizens, and to the data consistency with the known biology of the main mosquito species in Italy. In addition, we present the results of a first field validation of ZanzaMapp data as predictors of Ae. albopictus biting females and provide examples of large- and local-scale spatial representations of perceived mosquito abundance highlighting the potential of ZanzaMapp to contribute to the correct planning of control interventions. Finally, the paper discusses the added value of complementing conventional entomological surveillance/monitoring schemes with citizen science data collected by smart-phone apps. 2. Materials and Methods 2.1. ZanzaMapp Design and Release ZanzaMapp is the result of a collaborative effort between the Medical Entomology group of the Department of Public Health and Infectious Diseases in SAPIENZA University and GH s.r.l., a start-up of SAPIENZA University. The app was implemented as a HTML Single Page Application, so it runs both in a normal browser, as a web app, and wrapped in a native app (both Android (GH s.r.l., Rome, Italy) and iOS (GH s.r.l., Rome, Italy)) with Cordova. It is freely available in the Android and iOS app stores (currently available in version 1.1.2, which also includes the possibility to upload photographical records) and on the project’s website [ 16 ]. The present work focuses on data collected by ZanzaMapp 1.1.1 (workflow shown in Figure S1 ). Users are requested to fill in a brief questionnaire consisting in 4 multiple choice questions (Q): Q1—number of observed mosquitoes (possible answers: 0, 1–3, 3–30, >30); Q2—the time of the observation (possible answers: within an hour from the record; previous night; morning; afternoon); Q3—the location of the observation (possible answers: indoor vs. outdoor); Q4—observation associated to biting activity (possible answers: no, low, high). Questions 1 and 2 are compulsory (1,2) and are followed by the geo-location of the record. Questions 3 and 4 are optional, in order to minimize the effort requested to the user and likely maximize the number of records. Both the native app and the web app use the geolocation capabilities of the users’ devices to show the location on a map of the device at the moment the record is sent, and a pin is displayed by default in this location. Users are allowed to move the pin to a different location, if needed, as the record could refer to observations in the 24 h before it is sent (see Q2). Anonymized data are collected in a server, and a map including all the reports sent by all users in the previous week (completed with a heat map to show the areas of greater mosquito’s abundance) is made available to all users in the native-app and the web-app. Both native-app and web-app included sections/folders with (i) in-depth educational materials on mosquito species’ cycle, ecology, and public health relevance and (ii) recent news on mosquitoes and mosquito-borne diseases in Italy and beyond. The ZanzaMapp release on 4 May 2016 was followed by various advertising initiatives, particularly in weeks 18–19 when it was advertised by interviews in national TV news (RAI, Canale 5, SKY) and radio programmes and in national newspapers. In 2017, following the Chikungunya outbreak in the Lazio region, ZanzaMapp was promoted through a national television scientific dissemination programme (GEO RAI3, week 38) and in national and regional (Lazio) TV newscasts (week 41) and newspapers. In September 2016, ZanzaMapp was promoted in the island of Procida (Naples, Italy) within the framework of field site validation (see Pilot field validation below). In addition, in spring and autumn 2016 and 2017, ZanzaMapp was promoted through dedicated seminaries among students of Parasitology and Zoology at the Faculties of Medicine and of Biological Science of the La Sapienza and Tor Vergata Universities in Rome. No promotion was carried in 2018. Except for the advertisement during the pilot study in Procida and for the mentioning of ZanzaMapp in a local TV interview by the Mayor of Bari at the XXIX Congress of the Italian Society of Parasitology in June 2016, no public administration promoted ZanzaMapp use during the study period. 2.2. Descriptive and Statistical Analyses Descriptive statistics were computed to characterize app usage and user engagement based on ZanzaMapp records provided by citizen scientists across Italy from May 2016 to the end of 2018. In order to optimise the dataset to be analysed, a data cleaning procedure was applied, which removed records with default coordinates (when no GPS service is available the app opens the map at a default location) and records with coordinates outside Italy. We collected data on following environmental variables at each record location: (i) elevation (Source: available from ISPRA SINAnet [ 17 ]); (ii) imperviousness in a 150 m buffer, corresponding to a percentage of the substitution of the original (semi-) natural land cover or water surface with an artificial, often impervious cover(computed from Imperviousness dataset available from ISPRA SINAnet [ 17 ]); (iii) distance from the coastline (computed from coastline available from the Italian National Geoportal, [ 18 ]); (iv) distance from inland waters (computed from inland water bodies and river network available from the Italian National Geoportal, [ 18 ]). For each environmental variable we obtained a distribution of values and calculated the frequency distribution in each reported mosquito abundance category (0, 1–3, 3–30 and >30 mosquitoes. The relationship between the number of records and human population density was assessed by linear regression. The number of records and the total population within each Italian province were log-transformed (base10) and used as dependent and independent variables, respectively. A Generalized Additive Model (GAM) with Binomial distribution was applied to analyse the seasonal dynamics of mosquitoes as monitored by users. The following environmental variables were considered: (i) mean daily temperature, obtained from the gap-free daily MODIS Land Surface Temperature maps, a dataset created by Fondazione E. Mach using the Metz et al. 2014 [ 19 ] procedure applied to MODIS LST version 6, with a final resolution of 250 m; the temperature value corresponds to the pixel value at the coordinates of the records. (ii) Human population data obtained from the GSH-POP raster dataset with a spatial resolution of 9 arcsec; in this case, too, the selected valued is the value of the pixel identified by the coordinates of the records. All the data were managed with the GRASS GIS software [ 20 ]. The GAM was applied to a subset of data, considering only records flagged as being made in the last hour and during 2017 and 2018, to assess mosquito daily activity only and to avoid the confounding effect of the advertising campaign in the first weeks after the release of ZanzaMapp in June 2016. The records for each location i, day j and hour h (y ijh ) were categorized as high abundance (>3) or low abundance (≤3) and then modelled as a Bernoulli variable (Y). The logit transformed probability was regressed against year, period (summer, April to October; winter, December to March) and population density with a linear term, while for mean daily temperature (LST), and the interaction between hour of the day and period we considered thin plate splines. y ijh ~ Bernoulli (p ijh ), (1) Logit (p ijh ) = year j + period j + population i + f (LST ij ) + f (hours h × period j ), (2) E (Y) = p, (3) Var (Y) = p (1 − p) (4) The GAM was trained on a subset of the considered data (80%), and the model performance was evaluated on the excluded data (test set). 2.3. Management and Spatial Representation Tool An analytical tool coded in R language was developed in order to allow the simple and automatic processing of spatialized ZanzaMapp records (or of other spatialized mosquito data), analyse the report dataset, create map layouts and export results. The tool was bundled in the R package “CSmosquitoSp” (available at [ 21 ]) that makes it possible to combine spatialized mosquito data with spatialized information (presently available for the Italian territory only) corresponding to polygons representing administrative boundaries at different levels (i.e., provinces, municipalities, sub-municipalities, spatial grids) and incorporating information about human population, or alternatively, representing other custom polygon layers. Qualitative information about mosquito abundance, reported by citizen scientists in discrete numeric classes (0, 1–3, 3–30, >30 mosquito), is transformed into a numeric scale representing the median value for each class (0, 2, 17, 34 mosquito). The converted reports can be aggregated for a specified time interval over each spatial polygon using basic statistical methods (i.e., average), and positive records are computed as the percentage of records with a number of observed mosquitos >0. The perceived mosquito abundance is computed as fraction abundance (ranging from 0 to 1) for each polygon, by averaging the numeric transformed reports in a specific time interval. “Fraction abundance” is a fractional value, scaled in the range 0–1, of mosquito abundance. A value of “0” represents a spatial polygon where all records in a specific time interval reported a ZanzaMapp abundance of “0” (None) mosquitoes. A value of “1” represents a spatial polygon where all records in a specific time interval reported a ZanzaMapp abundance of “>30” mosquitoes. The fractional value is computed after converting the class records to class median values and averaging all the records inside each spatial polygon for a specific time interval. When scaling in the range 0–1, the divisor corresponds to the highest-class median value (i.e., 34). The following associated information related to uncertainties can be also computed: (i) reliability, expressed as the coefficient of variation calculated from the reports; (ii) sampling effort, representing the ratio between number of reports and human population. Optionally, the analysis can take into account the time of observation, in order to estimate the perceived abundance during daytime and night-time, i.e., associated to diurnal (e.g., Ae. albopictus in urban areas) and nocturnal (e.g., Cx pipiens in urban areas) species. Aggregating reports within administrative polygons to calculate the perceived mosquito abundance makes it possible to analyse the spatial and temporal distribution, combine them with the quantitative information about the human population, and support the integration with HLC estimates. CSmosquitoSp has been employed to create some examples of possible maps obtainable from the ZanzaMapp records (see Conclusion Section). To this aim, qualitative information about mosquito abundance, reported by citizen scientists in discrete numeric classes, is represented as perceived mosquito fraction abundance. 2.4. Pilot Field Validation ZanzaMapp data were compared with the results of conventional entomological monitoring carried out in September 2016 in Procida island, a small (3.7 km 2 ), highly touristic Mediterranean island in the gulf of Naples (Italy). The island is largely urbanized and densely inhabited (2833 inhabitants/km 2 —ISTAT 31/12/2018); this population density approximately doubles during the summer months, because of tourism. The typical architecture is characterised by family houses with their own ornamental and vegetable gardens, with plenty of opportunities for Ae. albopictus larval development (e.g., buckets filled with rainwater for plant watering). An intensive entomological field monitoring was carried out daily from 9 to 15 September, except for 14 September, due to adverse weather conditions, for a total of 6 days of collections. Human Landing Collections (HLCs) were carried out during the hours of highest Ae. albopictus activity (9:30–12:30; 14:30–19:30) in 164 randomly selected sampling spots by two teams of two trained people (all co-authors of the present paper). All experiments were performed in accordance with WHO guidelines and Italian regulations. The project was approved by the Municipality of Procida with municipal resolution n°52 of 7 July 2016. Considering the absence of arboviruses spreading in the study area and the methods utilized, no additional permits were required. In each sampling spot, HLC were carried out simultaneously for 5 min by the two collectors located at a 50-meter distance from each other. Collected mosquitoes were stored in silica gel for subsequent morphological identification. The use of ZanzaMapp was promoted among the citizens and tourists in Procida in the weeks before and during the entomological monitoring by an advertising campaign in the municipality website and in local newspapers, as well as by hundreds of flyers disseminated in public places (bars, restaurants, shops). The ZanzaMapp records from 2 September to 16 September 2017 were transformed into a numeric scale from 0 to 3 corresponding to 0, 1–3, 3–30 and >30 mosquito reported, respectively. The transformed ZanzaMapp records were then aggregated over spatio-temporal windows (see below) and compared to HLC data. The spatio-temporal windows were centred on each HLC. Different time-windows were considered in order to find the best balance between choosing a too large, and likely inaccurate, window or a too small one, which would likely imply the need to eventually discard a considerable number of HLC data and ZanzaMapp records. In order to explore how the choice of spatio-temporal windows could affect the relationship between observed HLC values and ZanzaMapp records, we considered for each HLC: (i) 11 spatial (circular) buffers of increasing radius (50 m step increases, from 50 to 500 m) centred on the HLC spot; (ii) 6 time windows starting from 6 days before the HLC and ending the day after sampling completion (as users may enter in the app a record referring to the previous night). For all transformed records falling inside a spatio-temporal window, we computed a spatially weighted mean of aggregated ZanzaMapp records (WM), with the weight (w) computed as a linear function of the radius of the buffer (centred in a HLC spot): w = −(1/radius) × distance + 1. Following this transformation, the WM values range from 0 (users record zero abundance) to 1 (very high abundance). HLC data not associated to any ZanzaMapp record within any specific spatio-temporal windows were discarded, implying that the sample database size depends on the choice of the spatio-temporal window considered. Thus, information criteria approaches could not be used to compare models. Regression models were created for each spatio-temporal window to investigate the relationship between the predictive performance of aggregated ZanzaMapp records and HLC data. The model was fitted using the Integrated Nested Laplace Approximation approach (INLA) in a Bayesian framework, whose flexibility and computational efficacy allow to extend the model in the future, if needed. The response variable was HLC count observations (y ij ) at location i and day j and modelled as a Poisson (Y). yij ~ Poisson (λ ij ) (5) log(λ ij ) = WM i + D i + hour ij + OP ij + ε j + ξ i (6) E (Y) = λ (7) Var (Y) = λ (8) Covariates were WM, % of wood (classified from aerial images available from the Italian National Geoportal [ 18 ]) at buffer 20 m radius centred on the HLC spot, distance (D) from coastline (m) (computed from coastline available from the Italian National Geoportal [ 18 ]), hour of HLC, and a qualitative variable differentiating the technicians (OP). Moreover, the model considered a random effect (ε) for the collection day with Half-Cauchy priors and a spatial field (ξ) modelled using Stochastic Partial Differential Equation (SPDE) with Matérn correlation. For each model, the following data were computed: (i) sample size, (ii) median number of records inside tested spatio-temporal windows, (iii) mean values and credible intervals of all parameter, (iv) Root mean squared error between predicted and observed HLC values in the test set. 3. Results 3.1. Citizen Interest and Commitment The numbers and temporal distributions of the 13,669 individual devices which downloaded ZanzaMapp and provided at least one record (10,669, 2206, and 794 in 2016, 2017, and 2018, respectively; hereafter referred to as new users) reflect the intensity of the advertisement efforts, with main peaks associated to major advertising events on national TV and radio programmes (blue bars in Figure 1 a). In the first week after the release of ZanzaMapp (week 18) and the three TV interviews (week 19, 2016), 4194 new users were recruited. Afterwards, the numbers declined to ~100/week at the end of August and were negligible during the overwintering season (i.e., after October 2016 until the end of May 2017). In late spring/summer 2017 (in the absence of a specific promotion of ZanzaMapp in the media), new users were <100/week until mid of September, when their rapidly increased up to 811 in the second week of October. This is likely to be associated to the Chikungunya virus outbreak, which caused almost 500 infected cases in Lazio in September–October 2017 [ 4 ] and which was largely covered by the media, creating serious concern in the population: This created the opportunity to promote again ZanzaMapp in TV and newspaper interviews. In 2018, when no advertisement was carried out, new users were <50/week. Of the overall users, 55 recruited in 2016 and 167 recruited in 2017 were still active in 2018. Figure 1. ZanzaMapp records from 2016 to 2018. ( a ) weekly distribution of mosquito abundance categories (0, 1–3, 3–30, >30, multicolour bars) and new users (blue bars). Range of y-axis varies between panels referring to different years in order to help interpretation; ( b ) spatial distribution. A total of 36,867 records were obtained for the Italian territory from May 2016 (first record sent 4 May 2016 09:09:50 utc) to end of 2018 (last record sent 31 December 2018 22:10:32 utc). Of these, 1968 were discarded due to default coordinates, resulting in 34,899 records considered for subsequent analyses (hereafter referred as records). As in the case of new users, the weekly distribution of records in the 3 years is highly uneven, reflecting again the intensity of the advertising campaign, but also mosquito seasonality, and indicating that users were more motivated to use the app when their perception of mosquito abundance (and nuisance) was higher (multicolour bars in Figure 1 a). The highest number of records (~5500) was obtained in the first week following ZanzaMapp release. Afterwards, records were >1000/week until end of July, >500/week until mid-September and decreased down to <50/week until the end of 2016. In 2017, records increased to ~150/week in the summer months until the second half of September, when they increased to 1366/week in late September/early October. From November 2017 to March 2018 (when at least the majority of Ae. albopictus is overwintering) records were <50/week (with no records in January and February 2017), and they increased to 200/week in second half of August. Of the 13,669 users, 64.6% submitted 1 record only, 15.2% of them 2 records, 16.7% 3–10 records, and 3.5% >10 records. In the case of recurrent users (i.e., users that submitted >1 record), the median and mean number of days between records was ~3 and 12 days (with highly skewed intervals between records, i.e., 25%, 50%, and 75% quantile of intervals between successive records <17 h, ~3 and 8.1 days, respectively, with 95% of intervals shorter than 43 days). This pattern is consistent with the temporal dynamics of records shown in Figure 1 a. With reference to the time of the observations, 9.2%, 21.8%, 22.9%, and 46.2% of the records were obtained in the morning, in the afternoon, in the night, or in the last hour, respectively, with patterns changing among years, whose biological significance is not straightforward to interpret ( Figure S2 ). The geographic distribution of the records was nationwide ( Figure 1 b), with a median and mean distance between records of ~1.5 km and 27.6 km, respectively (25%, 50%, and 75% quantile distance between records of 43 m, 1.5 km and 11.4 km, respectively, with 95% of intervals <120 km). A linear association is observed between ZanzaMapp records and population densities at log10 scale (where a 10-fold increase in population density correspond in a 19.7 increase in the number of records; Figure S3 ), confirming the expectation that the highest number of records would come from highly populated areas. The majority of records are from the Lazio Region (19.6%, 45.2%, and 34.2% in 2016 (total = 25,578), 2017 (total = 6187) and 2018 (total = 3134), respectively), reflecting the location of most of the people involved in the studies, Rome, and, in 2017, the increased interest in the app elicited by the chikungunya outbreak in the region [ 4 ]. Overall, results suggest a high success of ZanzaMapp in attracting potential users (as shown by the high numbers of new users following major TV promotion events) and a limited one in eliciting long-lasting commitment. The latter one, however, was not to be expected, as ZanzaMapp 1.1.1 did not provide the users with any feedback, incentive and/or notification (e.g., a connection with public health administrations, which could guarantee mosquito control interventions in areas with high numbers of high abundance records). These are known to be the key factors to ensure a long-lasting use of citizen science-based app/projects over time [ 22 , 23 ]. Interestingly, however, the not negligible number of citizens sending >10 records (472) and the fact that they were scattered across Italy (and not concentrated in Rome, where the authors of the paper encouraged colleagues, students and acquaintances to use the app) suggest an interest from a potentially high number of citizen in contributing to mosquito monitoring efforts. The above data refer to records associated with the two compulsory questions in ZanzaMapp (i.e., the number of mosquitoes observed and the time of the observation) which precede the record geo-localization on the map and the possibility for users to consult the map and see their own records as well as records from other users. The commitment of users was further assessed by looking at the proportions of records including feedback on the two optional questions, i.e., 77.5% (26,363/34,899) of records including feedback on the location of the observation (52% indoors vs. 48% outdoors) and 60.4% (12,889/21,329, following inclusion of this question in the app on 15-06-2016) including feedback on mosquito biting activity (no bites vs few bites vs several bites). This suggests that the majority of users felt engaged in completing the questionnaire but raises the question whether it would have been better to make the two questions compulsory before the geo-localization and the saving of the records. Indeed, this depends on the relevance of the questions (which in this case were aimed at differentiating between diurnal and nocturnal mosquito species and at assessing the nuisance level, respectively), and on the significance of the feedback obtained (see below). 3.2. Mosquito Abundance Records and Biological Significance The analysis of the records of mosquito abundance obtained depicts scenarios that are overall consistent with the known biology and population dynamics of Ae. albopictus and Cx pipiens (i.e., the most widespread species in Italy, particularly in urban areas from where most records were obtained), although some critical elements/biases are noticeable. The results of the spatial analysis for the whole set of data ( Figure S4 ) show that (i) the no mosquito category is more frequent than the other categories at higher elevations, reflecting the less permissive eco-climatic situation beyond 500 m [ 24 , 25 ]; (ii) the high abundance categories are more frequent in areas without full artificial surface cover, in agreement with recognised hot-spots in small green areas within a highly urbanized environment in Italy [ 6 , 26 ]; (iii) the high abundance categories are more frequent in areas closer to the coastline; notably, although no entomological data are available to confirm this results, it is noteworthy that all outbreaks of chikungunya in Italy started in coastal sites [ 4 ]; (iv) lack of clear distribution patterns related to distance from inland water bodies. The results of the temporal analysis show first of all a clear seasonal pattern (with values >75% from week 20 to 43) in the proportion of the different categories of mosquito abundance recorded (0, 1–3, 3–30 and >30 mosquitoes) ( Figure 2 ). The patterns of the two highest abundance categories (>30? mosquitoes) closely reflect expectations based on known mosquito seasonality in Italy, while the pattern of the low abundance categories (1–3 mosquitoes) show high frequencies also in the winter months (with peaks >50% in November 2017–March 2018). The latter results are consistent with previous reports of overwintering adults of the two most widespread urban species, Ae. albopictus and Cx pipiens , in Italy [ 27 , 28 ]. However, it should be noted that a bias towards positive records is to be expected, as citizens are more motivated to send a record when they see a mosquito or are bitten by it. This general bias is likely to be stronger in the winter months, when users can completely forget about ZanzaMapp unless they unexpectedly see a mosquito and are more motivated to send a record by the unexpected encounter, than in warmer months when mosquito presence is the rule. Figure 2. Seasonal distribution of proportion of ZanzaMapp mosquito abundance categories. Dark blue = zero mosquito/week (m/w); light blue = 1–3 m/w; green = 3–30 m/w; yellow = >30 m/w; Gap between week 51 of 2016 and week 8 of 2017 is due to lack of records. Second, the GAM implemented to test the relationship between records of low (≤3) and high (>3) perceived mosquito abundance in 2017 and 2018 and human population density, temperature and hour of the day revealed interesting features ( Table 1 ). The probability of recording a high mosquito abundance followed a similar dynamic in 2017 and 2018, increasing with temperatures up to 29 °C and decreasing at higher temperatures ( Figure 3 ). This is consistent with the biology and seasonal dynamics of the main mosquito species in Italy [ 29 , 30 ]. In the summer period, high abundance records are higher in the morning (between 9:00 and 11:00) and in the afternoon-evening (between 17:00 and 22:00) consistent with the biting patterns of Ae. albopictus [ 31 ] and Cx pipiens [ 32 ]. This relationship is not observed during the 2017–2018 winter period (November-March). Interestingly, the probability of recording high mosquito abundance negatively correlates to human population density, consistently with the fact that, at a given absolute density of mosquito, the mosquito/host rate decreases at higher human density. This draws attention to a (largely neglected) bias in the estimates of human-mosquito contact (and consequent risk of arbovirus transmission) based on estimates of mosquito abundance obtained by entomological monitoring only and highlights the possible value of the citizen science approaches to correct this bias. Figure 3. Thin plate splines (y-axis: smoothers) from GAM testing the relationship between ZanzaMapp records of low (≤3) and high (>3) mosquito abundance and human population density, temperature, and hour of the day in 2017 and 2018. LST = land surface temperature. Solid lines represent the mean fitted values, dashed lines represent the 95% confidence intervals. Table 1. Result of Generalized Additive Model (GAM) testing the relationship between ZanzaMapp records of low (≤3) and high (>3) mosquito abundance and human population density, temperature, and hour of the day in 2017 and 2018. Human population density was standardized (mean = 376.282, standard deviation = 375.856). Notably, the testing of GAM performance to evaluate model accuracy in predicting high-mosquito abundance based on available data (human population density, temperature, and hour of the day) confirms that the model underestimates user’s records of high mosquito abundance. Specifically, in the train test, the model correctly classified the occurrence of mosquito resulting in a good (i.e., 70.1%) match between fitted and observed values (fitted values classified positive when >0.5). However, the model produced a 25% of false negative predictions (fitted value <0.5 but observed positive record). The same pattern was observed in the test set with the GAM correctly predicting 69.5% of observations (95% CI 67.4–71.8) but showing a 26.2% of false negatives. In other words, the model underestimates high-mosquito abundance, as reported by ZanzaMapp users. This is relevant particularly with reference to the potential use of model estimates to infer mosquito abundance. Third, the relationship between the proportion of ZanzaMapp records of no, low, high biting activity and records of no, (0), low (1–3), high (3–30) very high (>30) mosquito abundance shows a strong consistency between a prevalence of no-bites records and records of lack of mosquitoes and between a prevalence of high biting activity and records of very high mosquito abundance ( Figure 4 ). This strengthens the quality of the reports and the significance of the possibility of exploiting them to assess mosquito abundance and mosquito/human contacts. Figure 4. Proportion of ZanzaMapp records of no, low, high biting activity within the 4 mosquito abundance categories (0, 1–3, 3–30, >30). Finally, we compared the population dynamics of the mosquito records reported from outdoors in the morning/afternoon (likely mostly associated to Ae. albopictus ) versus those reported from indoors in the night hours (likely mostly associated to Cx pipiens ). The results (not shown) are not consistent with the expectation to see different dynamics reflecting the earlier start of the reproductive season for Cx pipiens compared to Ae. albopictus . This suggests that, in the current form, ZanzaMapp does not discriminate between an exophilic/diurnal and endophilic/nocturnal species, possibly due to the low number of night hour-records. 3.3. Pilot Field Test Validation in Procida Island. Human Landing Catches (HLCs) and ZanzaMapp promotion were implemented in September 2016 in the island of Procida ( Figure 5 A). Overall, 191 ZanzaMapp records from 75 users from the island were obtained. Of these, 15.7% were recorded during night hours and were discarded from the subsequent analyses, as they likely referred to nocturnal mosquito species (e.g., Cx pipiens ) rather than to Ae. albopictus , which was the only species collected during the diurnal HLCs carried out in the same week, yielding a total of 764 females and 52 males. Figure 5. Procida Island (Gulf of Naples, Italy). ( A ) Location of ZanzaMapp records (red circles) and Human Landing Collections (HLC; black squares) in September 2016. ( B ) Aedes albopictus abundance estimate based on ZanzaMapp records. Black lines represent roads. In order to be able to validate the results obtained by ZanzaMapp as a method to estimate Ae. albopictus abundance/nuisance, we first explored how the choice of different spatio-temporal windows could affect the relationship between the observed HLC values and the ZanzaMapp records. The results showed a positive relationship between the weighted mean and HLC for some spatio-temporal windows. Shortest (i.e., 1 day or 50 m) and longest (i.e., >3 days or >150 m) spatial/temporal windows provided lower or not significant correlations ( Figure S5 ). This pattern is probably due to the scarcity of data (in the shortest spatio-temporal windows), as well as to possible heterogeneities in mosquito distribution or to the inclusion of records which were temporally or spatially unrelated to the HLC observations (given the wider spatio-temporal windows). These findings suggest that the most appropriate way to obtain valuable information regarding mosquito abundance from ZanzaMapp records is to consider records sent within 100 m and in the 2–3 days preceding the HLCs. Figure 5 B shows the estimated abundance of Ae. albopictus adults in Procida island based on a 100 m-3 days spatio-temporal window. 4. Discussion A few citizen-science projects have been developed over the last years to complement and/or replace laborious and expensive entomological monitoring and ultimately contribute to prevent the risk of mosquito borne diseases [ 9 ]. In particular, two of the most successful ones, MosquitoAlert in Spain and Mückenatlas in Germany [ 13 ], focus on monitoring the spread of invasive Ae. albopictus —which is still in a process of expansion in these Countries—and to identify other possible invasive Aedes species. ZanzaMapp was developed in Italy—where Ae. albopictus and Cx pipiens are the most common species in urban areas—with the alternative/complementary goal to monitor citizen’s perception of mosquito abundance and nuisance. This means that while MosquitoAlert and Mückenatlas goals are to obtain validated records of the invasive species (by photos and biological samples, respectively), the objective of ZanzaMapp is to obtain as many reports of mosquito presence/nuisance as possible. This was pursued by asking citizens to fill in a very simple and fast questionnaire which was expected to increase the number of records but did not allow validated species identification. Therefore, for their inherent nature, ZanzaMapp data are affected by several biases, such as differences in individual perception, mistakes in the recording procedures, misidentification of other insects as mosquitoes, limits in differentiating between day- and night-biting species. Nevertheless, the results highlight a consistency between the patterns obtained by the analysis of ZanzaMapp records and the known spatio-temporal dynamics of the main mosquito in Italy. Given that the highest number of records is shown to come from highly populated areas, it is reasonable to assume that the results obtained mostly refer to Ae. albopictus and Cx pipiens , although this may not be the case in some areas. Moreover, the results from the pilot experiments conducted in Procida island show that a relationship exists between ZanzaMapp records and the number of host-seeking Ae. albopictus . Further studies are needed to confirm this on a wider geographical scale. While the high numbers of downloads and records obtained with a very limited advertising effort support the potential for a widespread use of ZanzaMapp, the results showed that most users did not felt engaged in an actual monitoring activity over time. This was not unexpected, given that ZanzaMapp 1.1.1 did not provide any feedback, nor rewards to users. A possible relevant feedback could be represented by maps of mosquito abundance/nuisance produced on the basis of ZanzaMapp records and made available in real-time to citizen and administrations. Figure 6 shows, an example, four maps based on ZanzaMapp data collected in Italy (a), Lazio Region (b), and Rome urban area (c–d). Although very rough and subject to several potential biases (as highlighted above), the former two maps (a,b) highlight the potential value of a citizen science-based approach to produce an overview of mosquito perceived abundance on a large-geographical scale, which is impossible to obtain with entomological monitoring approaches. On the other hand, the smaller-scale maps (c,d) clearly show the potential of the exploitation of citizen records by local public administrations in order to focus control interventions on areas where mosquito nuisance is more acutely perceived. Figure 7 shows two maps (a,b) based on ZanzaMapp data collected in the Lazio region during two consecutive weeks in October 2017, in the middle of the chikungunya outbreak which caused over 400 hundred human infections in Lazio, especially in the city of Anzio [ 4 , 33 ]. Interestingly, the number of records considerably increased from a to b, possibly due to increased concern of the population for the outbreak and to actual increases in nuisance expected in mid-October in the region [ 6 ]. Although anecdotic, it is interesting to note that the maps reflect a high variability in mosquito abundance among Municipalities and that the Municipality of Anzio (i.e., the core of chikungunya outbreak [ 34 ]) is highlighted as highly infested. Figure 7 c shows the temporal profile of the percentage of positive records (≥1 mosquito) reported in the province of Rome in 2016–2018, which could support the optimization of the scheduling of mosquito control interventions. Figure 6. Scales of perceived mosquito abundance based on ZanzaMapp records (May 2016–December 2018) for Italy ( a ), Lazio region ( b ), administrative units in Rome urban area ( c ), and 1 km-spatial grid in Rome urban area ( d ). Inner squares represent maps of sampling effort, i.e., the ratio between number of ZanzaMapp records and human population. Figure 7. Scales of perceived mosquito abundance based on ZanzaMapp records aggregated for the Lazio region for the weeks 1 October 2017–7 October 2017 ( a ) and 8 October 2017–14 October 2017 ( b ). Inner squares represent maps of sampling effort, i.e., the ratio between number of ZanzaMapp records and human population. ( c ). Temporal profile of the percentage of positive records (≥1 mosquito) reported in the province of Rome in May 2016–December 2018. The grey area from January 2017–April 2017 refers to interpolated data, due to lack of ZanzaMapp records. We believe that a large community participation could be gathered in the future, should ZanzaMapp (or a similar app) be endorsed and properly advertised by public administrations (e.g., Municipalities). A higher number of records will indeed make it possible to produce real-time maps similar to those shown in Figure 7 , but with higher spatial resolution, which could complement the entomological data (if any) and eventually be used to identify hot-spot areas on which to target mosquito control interventions, thus improving their effectiveness with modest added costs. Indeed, economical and operational constraints in entomological monitoring make an information-based and spatially targeted control of mosquitoes such as Ae. albopictus in public urban areas very rarely feasible, despite the distribution of the species being known as uneven [ 6 ]. A more focused and cost-effective mosquito control would indeed represent an incentive for citizen, who would feel directly involved in the monitoring process and in improving the intervention’ effectiveness. Of course, other incentives (such as a direct feedback on mosquito control activities by public administrations via the app itself) could be planned to increase ZanzaMapp usage. A very positive side-effect of the involvement of civil society in the effort to monitor and eventually better control mosquitoes through mobile phone apps is also the potential for massive education and awareness, which can lead to new models of open government and innovation [ 35 ]. Indeed, educational material and news in the mosquito field are available both on the ZanzaMapp.it website and in the app. Continuous updates of these sections represent an important instrument to increase user’s affection for the app and promote its use. 5. Conclusions In conclusion, the results obtained with very limited budget by the joint efforts of GH private company and a group of researchers (mostly with no permanent position in the Italian academy, nor in the public sector) confirm the high potential for scaling-up innovative citizen science-based approaches as tools for improved mosquito control. Although we did not carry out an analysis of the costs associated with the running of ZanzaMapp and data analysis vs those associated to classical entomological monitoring, it is important to note that costs, in the case of ZanzaMapp, will be very low and mostly associated to non-recurring investments in technology, to community engagement, and to data analysis. In the case of Mosquito Alert (which also required specialized entomologists for mosquito identification), these costs were estimated to be 7.6-fold lower than standard entomological monitoring [ 9 ]. Synergies between scientists, public health institutions, and public administrations in Italy are now needed to promote the scaling-up of the approach as a complementary tool to entomological monitoring or as the only one in case of lack of resources for the latter. Beyond the national scale, as highlighted by Bartumeus et al. [ 36 ] “the challenge is to exploit the inherently scalable nature of Internet networked citizen science to offer an open global toolkit that can aid in the fight against mosquito at the global scale”. This would imply the generation of data and method standards across different projects, as well as the development of a modular project where code and data can be easily shared and reused in other countries, thus facilitating structural interoperability and shared global knowledge. ZanzaMapp could thus evolve as a module focused on the perception of mosquito abundance/nuisance of this global toolkit, as already discussed and agreed during the 2017 workshop sponsored by UN Environment and organized by the Wilson International Center for Scholars’ Science and Technology Innovation Program (STIP), and the European Citizen Science Association (ECSA) in the frame of which the Global Mosquito Alert Consortium was launched, with the participation of representatives of the most successful mosquito pilot projects exploiting apps [ 11 ]. This meeting marked the start of the Global Mosquito Alert initiative aiming at contributing to the global surveillance of mosquito species by pooling different “modules” with different goals, ranging from the provision of records of spatial distribution of mosquito species and breeding sites based on image validation by expert entomologists to real-time information on mosquito nuisance/abundance by citizens in a single app. Supplementary Materials The following materials are available online at https://www.mdpi.com/1660-4601/17/21/7872/s1 . Figure S1: Workflow of ZanzaMapp. Figure S2 percentage of ZanzaMapp’s mosquito-recorded values along the year. Figure S3: Relationship between population density and number of ZanzaMapp records. Figure S4: Violin plots of environmental variables for each reported mosquito abundance category. Figure S5: Relationship between HLC and ZanzaMapp records within different spatio-temporal windows. Author Contributions Conceptualization, C.B., B.C., and A.d.T.; methodology, B.C., A.d.T., M.B., and M.M.; software, C.B., P.M. and F.F.; validation, B.C., M.M., P.C., C.M.D.M., L.I., V.P., and M.S.; formal analysis, B.C., M.M., L.D., F.F., M.B., and A.d.T.; investigation, B.C., V.P., L.S., P.M., P.C., C.M.D.M., and M.M.; data curation, P.C, B.C., V.P., and M.S.; writing—original draft preparation, B.C., M.M., C.B., F.F., and A.d.T.; writing—review and editing, M.B., L.D., and M.S.; visualization, M.M. and F.F.; supervision, A.d.T., C.B., B.C., and M.S. All authors have read and agreed to the published version of the manuscript. Funding The work was partially supported by Progetti Medi Ateneo 2017 of Sapienza University. Acknowledgments We are grateful to Italian citizens as well as students and faculty members of Sapienza and Tor Vergata University in Rome for contributing their records to ZanzaMapp. We thank the Municipality of Procida for assisting the team during the experimental work in 2016. The work was done within the framework of AIM-COST Action (CA17108). Conflicts of Interest The authors declare no conflict of interest. References Bruguerasad, S.; Fernández-Martínez, B.; Martínez-de la Puente, J.; Figuerola, J.; Montalvo Porro, T.; Rius, C.; Larrauri, L.; Gómez-Barroso, D. Environmental drivers, climate change and emergent diseases transmitted by mosquitoes and their vectors in southern Europe: A systematic review. Environm. Res. 2020 , 191 , 110038. [ Google Scholar ] [ CrossRef ] [ PubMed ] Lazzarini, L.; Barzon, L.; Foglia, F.; Manfrin, V.; Pacenti, M.; Pavan, G.; Rassu, M.; Capelli, G.; Montarsi, F.; Martini, S.; et al. First autochthonous dengue outbreak in Italy, August 2020. 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Citizen Science: A Gateway for Innovation in Disease-Carrying Mosquito Management? Trends Parasitol. 2018 , 34 , 727–729. [ Google Scholar ] [ CrossRef ] Figure 1. ZanzaMapp records from 2016 to 2018. ( a ) weekly distribution of mosquito abundance categories (0, 1–3, 3–30, >30, multicolour bars) and new users (blue bars). Range of y-axis varies between panels referring to different years in order to help interpretation; ( b ) spatial distribution. Figure 2. Seasonal distribution of proportion of ZanzaMapp mosquito abundance categories. Dark blue = zero mosquito/week (m/w); light blue = 1–3 m/w; green = 3–30 m/w; yellow = >30 m/w; Gap between week 51 of 2016 and week 8 of 2017 is due to lack of records. Figure 3. Thin plate splines (y-axis: smoothers) from GAM testing the relationship between ZanzaMapp records of low (≤3) and high (>3) mosquito abundance and human population density, temperature, and hour of the day in 2017 and 2018. LST = land surface temperature. Solid lines represent the mean fitted values, dashed lines represent the 95% confidence intervals. Figure 4. Proportion of ZanzaMapp records of no, low, high biting activity within the 4 mosquito abundance categories (0, 1–3, 3–30, >30). Figure 6. Scales of perceived mosquito abundance based on ZanzaMapp records (May 2016–December 2018) for Italy ( a ), Lazio region ( b ), administrative units in Rome urban area ( c ), and 1 km-spatial grid in Rome urban area ( d ). Inner squares represent maps of sampling effort, i.e., the ratio between number of ZanzaMapp records and human population. Figure 7. Scales of perceived mosquito abundance based on ZanzaMapp records aggregated for the Lazio region for the weeks 1 October 2017–7 October 2017 ( a ) and 8 October 2017–14 October 2017 ( b ). Inner squares represent maps of sampling effort, i.e., the ratio between number of ZanzaMapp records and human population. ( c ). Temporal profile of the percentage of positive records (≥1 mosquito) reported in the province of Rome in May 2016–December 2018. The grey area from January 2017–April 2017 refers to interpolated data, due to lack of ZanzaMapp records. Table 1. Result of Generalized Additive Model (GAM) testing the relationship between ZanzaMapp records of low (≤3) and high (>3) mosquito abundance and human population density, temperature, and hour of the day in 2017 and 2018. Human population density was standardized (mean = 376.282, standard deviation = 375.856). Parameter Estimate Std. Error Z-Value Pr (>|z|) Intercept −0.839 0.065 −12.895 <0.001 Year (2018) −0.016 0.090 −0.177 0.860 Period (Winter) −0.816 0.232 −3.516 <0.001 Population −0.197 0.040 −4.890 <0.001 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/ ).
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Full text of Commercial and Financial Chronicle : December 18, 1920, Vol. 111, No. 2895 | FRASER | St. Louis Fed Full text of Commercial and Financial Chronicle : December 18, 1920, Vol. 111, No. 2895 •a \ / u v V & INCLUDING ©sink £z Quotation Section RailTxay & Industrial Section Electric Railway Earnings Section Banters* Convention -Section State and C0™"0HTEP "* "ao^ WILLIAM B. DAKA COMPANY, NEW YORK. vol 111. {jjggpWg ENTERED AS SECOND-CLASS MATTER JUNggS, *870, ATTHg FOffOmCt AT NEW YORK, HEW YORK, UNDER Railway Se£tH>3t City Section THE ACT OK MARCH S, NEW YORK, DECEMBER 18, 1920. Jftnanrial I87», NO. 2895. 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INVESTMENT SECURITIES BOSTON 15 State Street# - 24 Broad Street, BONDS WE OFFER NEW YORK Bankers and Dealers Investment Light Securities Proven Power and Correspondence BOSTON 19JCONGRESS ST., Solicited SPRINGFIELD PROVIDENCE ELECTRIC BOND & SHARE CO. (Paid-Up Capital and Surplus $24,000,000) Richardson# Hill & Co. BROADWAY. NEW YORK MUNICIPAL AND RAILROAD NEW & Company Exchange Place YORK BONDS investment Securities For Conservative Investment SO Congress Arthur Lipper Now Street and 1870 Established 71 AND SECURITIES BOUGHT SOLD ON St. COMMISSION BOSTON R. L. Day & Co, Branch Members Boston Stock Exchange MsaUbe-s^New York Stock Exchange Chicago Stock Exchange Congress St., Boston Offices N. Y. Stock Exchange Waldorf-Astoria Hotel,IV. Y N. Y. Cotton Exohange 35 11 East 44th St.. N. Y. N.Y Coffee A Sugar Exch. Saratoga Springs, New York Correspondents REMICK, HODGES & CO. Atlantic City. N Philadelphia Stock Exoh. Chicago Board of Trade N. Y. J. N. J. W#st End, Long Beach, N. Y. k 3mt 1797 Founded PARKINSON & BURR We Specialize in Seasoned Members of the New York and Boston Stock Exchanges Investments 53 State Street 7 Wall Street 30 Municipal Bonds BOSTON NEW YORK Pine Street Government and WjNiamP. (ompton Co. New York INVESTMENT BONDS 14 Wall Street, BONDS New York Cincinnati St. Louis New Orleans Chicago Baker, Ayling & Young W. F. Ladd & Co, RAILROAD BONDS INDUSTRIAL BONDS BOSTON PUBLIC UTILITY PHILADELPHIA PAUL Investment BONDS H. WATSON INVESTMENT SECURITIES 55 William Securities H. Mountague St., N. Y. Telephone: John 1832 Vickers BONDS 49 Wall St. Tsl. Han. ««?• New York GUARANTEED STOCKS FOUNDED 1852 Investment Securities Foreign Letters of /Credit Exohange Travelers' Checks ESTABLISHED 1865 Correspondents Thomas C. Perkins eAxc/Ws ]*Clo^e>u£Co 5 Nassau St., N. Y. MEMBERS NEW YORK STOCK Deal Constructive Banking Throughout ths World, Krnnifi {NarfioU 8c Kulwc (embers New York Equitable Building Stock Exchange 15 State Street in Boston, Mass. Underlying Railroad Bonds 36 Pearl Street Hartford, Conn. and Tax-exempt Guaranteed & Preferred Stocks4 ^Railroad & Telegraph Co. Specialist Inc. eighteen Watkins & Co. in the Financing of established and pros¬ years perous L HOWARD GEORGE & CO., for Entire Industrials. stock issues 7 Wall Street NEW YORK - * underwritten end distributed Investment Securities Investment Bankers 81 Stato Street BOSTON, MASS. w Now York EXCHANGE 1 DEC. 181920.] THE CHRONICLE v Canadian Canadian Government and Municipal Bonds BANK OF MONTREAL THE CANADIAN BANK Established CAPITAL PAID UP These bonds offer exceptional oppor¬ tunity for sound investment. Ifjpurohased J^now they will yield from 7% to 7yz% 22,000,000 UNDIVIDED PROFITS TOTAL ASSETS - Head request. Incorporated ■■■■■' YORK Breaches Genera) Manager, Sir John Alrd. Assistant General Manager, H. New Paris, F. B. C. L. C. Bank of Montreal, (France). York, Chicago, Spokane, San Francisco—British American Bank (owned and controlled by the Bank of Banking and Exchange business description transacted with Canada. LONDON British Guiana and West Street. ST8W B. BRITAIN: The Bank of Scotland, <2o & GREAT of The Bank of England, Africa—The Colonial Bank (in which an interest is owned by the Bank of Montreal). Jl'&'Jlmcs OFFICE—2 Lombard BANKERS IN Indies, [Agents Travelers' Cheques and Letters of Credit Issns# available in all parts of the world. Montreal). West } made at all points. Agencies: In the United States—Mew FRANCIS, FOSTER, Buy andVSeli Sterling and Continental Exchange and Cable Trasf era. Collections London, England, and at Mexico City. In V. F. Joo» York'Office, 16 Exchange Plac* J|. STEPHENSON,] Manager. and $15,000,WS .$15,000,081 President, sir Edmund Walter, C.V.O., LL.D., D.O.I Office—MONTREAL Throughout Canada and Newfoundland. At Toronto, London, Eng., Winnipeg:, Montreal UP*CAPITAL RESERVE MEREDITH, Bart., President. General NEW 1,251,850 PAID 560,150,812 - Sir Frederick Williams-Taylor Wood, Gundy & Go. 14 WALL STREET, - HEAD WOFFICE, TORONTO SIR CHARLES GORDON, G.B.E., Vlce-Pres. United States funds on OF COMMERCE 122,000.000 . REST SIR VINCENT Principal and interest payable In Full^Particulars C-20 100 Years over Lloyd's Bank, Limited. Getabteied M9 -Membcwloeonto Stock GxduMgs , , THE BANK OF NOVA SCOTIA (B<an<a.di<£Ln ^ <*o\«rwrttfnt, Municipal & Corporation Securities United Financial Corporation Limited (Incorporated 1832) PAID-UP RESERVE TOTAL OVER Head Office, Halifax. N. S. Montreal Victoria "BuC. $9,700,661 18,000,000 280,000,001 FUND ASSETS Z4-VtOAdwayf -Tkiofatie Toronto CAPITAL INVESTMENT BANKERS Chicago Montreal London Toronto General Manager's Office, Toronto, Ont. 330 branches throughout Canada, Newfoundland! Cuba. Jamaica. Porto Rico, Dominican Republte' and is Boston, Chicago and New York. Commeffclal and Travelers' Credits Issued, available in all on Canada or West Indian negotiated or collected by aw parte of the world. Bills points favorably branches in the United ^States. Correspondents invited. Affiliated with Canadian Government, Provin¬ Municipal and Corporation cial, Guaranty Trust Co. of New York. New York Agency, London, England, Branch, 55 Old Broad St., E. C. 2. Bonds Bought—Sold—Quoted Members IT Montreal Stock Canadian in St. John in Great Britain Exchange I. &ank Midland of Scotland. THE Montreal * CANADIAN GOVERNMENT, CANADIAN INVESTMENT Royal Co. Daly & A. Issues Bond Street, London Joint City & Bank, Ltd. Correspondents GREENSHIELDS & CO. Dealers Wall Street* 52 H. F. Patterson, Agent. MUNICIPAL ROYAL BANK OF CANADA Established 1869 AND CORPORATION BONDS .._$19,000,000 Reserve Funds 19,000,000 Total Assets...... ...590,000,000 Capital Paid Up SECURITIES ... Offerings on Bank of Toronto Request Correspondence Invited Building ONT. TORONTO, Head Office.. SIR McDonagh, Somers & Co. Dominion Bank Building The Dominion TORONTO, CANADA HEAD Paid Up RURNEfT. u PORTEOUS & C9 St. STOCK BOND AND TORONTO OFFICE, Capital Total assets _ Sir Edmund Osier, *6,009,000 7,739,000 143,000,000 Clarence A. Bogert, Genera! Manager, President U Street John Bank Reserve Fund & Undivided Profits MeabmHontraESto^Ixdange 17 New York Agency, 51 Broadway C. 8. Howard. Agent Montreal BROKERS M. S. WHEELWRIGHT & CO. HERBERT E London Branch, 73 Cornhill S. L. Jones, Manager CANADIAN AND FOREIGN BOUGHT L. C. Montreal 8. HOLT, President Vlce-Pres. & Man. Directs NEILL. General Manager PEASE, E. 700 Branches throughout CANADA and NEW* FOUNDLAND, In CUBA. P6RTO RICO DOMINICAN REPUBLIC, HAITI, COSTA RICA. COLOMBIA and VENEZUELA, BRIT¬ ISH and FRENCH WEST INDIES. BRITISH HONDURAS and BRITISH GUIANA. ARGENTINE—Buenos Aires. BRAZIL—Rio de Janeiro. Santos. Sao Paula URUGUAY—Montevideo. SP^IN—Barcelona, Plaza de Cataluna. LONDON OFFICE—Prtnces Street, B. O NFW YORK AGENCY—68 William St. e*. T. Walker, J. A. Beataon, E. B Mclnet nrd J. D. Leavftt. Agents. fitENCH AUXILIARY: The Royal Bank Canada (France), PARIS, 28 Rue de Quatre-Septembre. EXCHANGE AND SOLD Limited TRAVELERS' Canadian Investment Securities AND LETTERS COMMERCIAL OF CREDIT HERDMAN & COMPANY Members Transportation Building MONTREAL | 132 St. Peter St., 63 Sparks St., QUEBEC Montreal Stock Exchange Bankers & OTTAWA Dominion Broken Express Building MONTREAL R. C. Matthews & Co. CANADIAN BONDS CANADIAN SECURITIES CANADIAN tfoussERWmr'GMPArar INVESTMENT TORONTO C. P. R. Bid*. BONDS BANKERS CANADA TORONTO Specialists in GEO, B. INVESTMENTS 72 Trinity Place NEW YORK. N. Y. FOR SALE—Timber, Coal, Iron, other properties Confidential Negotiations Settlements and l/nitad States Ranch and Investigations Grand Trunk, Grand Trunk Pacific, Canadian EDWARDS and Northern Canada Canadian Pacific Securities AO Canadian Issues Dealt in. i^milius Lewis Building, New York Established Mawtreal Direct Wires Tarant- Jarvis & Co. INVESTMENT TRUAX, HIGGINS CO. Purchases of Property, West Indies Northern JARVIS BLDC. BANKERS 1891 TORONTO, CAW* [VOL. 111. CHRONICLE THE VI foreign Australia and Zealand New LONDON ; BANK LIMITED LIMITED BANK OF NEW SOUTH WALES v-.f (ESTABLISHED 1817.) Liability'of Proprietors-- S3,838,908 QSZBrA**t* Assets 81st March, RUSSELL FRENCH, General Manager* JOHN Sir 1380 384,083,000 $ OT,m,tii ISSUED CAPITAL Deposits (June 30 1920).-367,667,821 . 87,800,000 ToPaid-up Capital 82,800,0001 teeervb Fund. £2.830,000/gather _ . 'leserve Liability or _ _ £7,000,008 HEAD OFFICE EVERY DESCRIPTION OF BANKING BUSINESS TRANSACTED dVER 1.460 OFFICES IN ENGLAND & WALES Incorporated 1880 . £14,210,88* — ...£296,059,188 DEPOSITS Address: The Foreign OVERSEAS BRANCH: WE" : £20,000,615 —. RESERVE FUND 8, Threadneedle Street, London, E. C. X. MthoriMd and Issued— throughout towns AUTHORIZED CAPITAL ...» 19, THREADNEEDLE STREET, E.C* 2 Established 1837 banking all in Capital...—£88,096,868 Paid-up Capital...—— 10,840,111 Reserve Fund 10,840,111 London Office Sapttal— 1,499 branches in England and Waist and over the world. of Australian Banking Business. Ureal and other Produce Credits arranged. THE BNION BANK OF AUSTRALIA Limited Ltd. 54, Lombard St., London, E. C., Eng« Esq., Agents description mORGE STREET Usts» Bank, HEAD OFFICE: K.B.E., HeadOffiea Western South 8c McKENNA Joint Managing Directoru Subscribed SYDNEY been amalgamated the has Provincial 8. B. Murray, Esq.. F. Hyde, E. W. WooUey, Esq. 881 BRANCHES and AGENCIES In the Australian States, New Zealand, FIJI. Papua (New Guinea), and London, The Banktransacts tvsrr which with Chairman: The Bight Hon. R. 'ic!»7<!OO2 SSLS? rSEd*1 "'loser ts BARCLAYS BANK JOINT Gin & MIDLAND 68 ft 86, Old Broad Street, London, E. C. Manager, 268, Fenchurch Street, 1 London, B. C.. Ksilts* ^ £S,180,0M Proprietors--.-£5,000,000 A Reserves. £10,180,000 89 M $38W SOUTH WALES. 19 in QUEENSLAND, Btt SOUTH AUSTRALIA. 21 In WESTERN AUSTRALIA. 8 in TASMANIA and 44 in NEW Zealand. Total leaved Capital OFFICES ATLANTIC 'Aqultania," 'Mauretanla" "Imperator," V&e Bonk bat 43 Branches in VICTORIA. Banca Italiana Di Sconto Affiliated Bankk BELFAST BANKING LIMITED COMPANY, with which Over 110 Offices In Ireland THE CLYDESDALE BANK, Manager—W. J. Essaaae. Assistant Manager—W. A. Lalng and the LIMITED Secieta Over 150 Offices in Scotland ' : # ■ LIMITED Capital and Surplus Incorporated in New South fatd-up Capital 819,960,860 Undivided Profits Valet. Branches in: .£2,000,000 .... $8,100,808 .... India Straits Settlements — 2,040,000 China Java feeerre Liability of Proprietors—.. 2,000,000 Japan Panama Philippine Islands Santo Domings San Francisco Swerve Fund..— — £6,040,000 London Drafts payable en demand, and Letters ef Otedtt are Issued by the London Branch on the Central Management and Head Office: ROME' . Special Letters of Credit Branch In Rem* (formerly Sebaati & BeaM), 20 Piazza di Spagxta. Foreign Branches: FRANCE: Paris, 2 Rue Is Peletier angle BeuJd. das. Itaheas; BRAZIL: See Paulo and Santos; NEW YORK; Italian Discount & Trust Co., 899 Broadway. Offices at Genoa, Mflan, Naples, Palermo. Turin, Trieste, Veaiee, Florence, Bologna. Catania, Leghorn, and over 100 Branches in tbs London Clearing Agents: Barclay's Bank. Ltd., 108 Fauchurch Street, E. O. EVERY Mead Office. Branches and Agencies ef the Bank Bills on Australasia or collected. Remittances cabled, Now Sydney, South KIND Birchln Lombard Lane. OF Wales ROBERT BRUNNER Street, The Mercantile Bask of Info Ltd. E. O. Htoi Banker and Broker Office 15 Gracechurch Street, Bases Espasoi del Rio defLa Plata 78 Capital t Raines A a rue de la Lol Reserve Liability of Shareholders.—... Cable Address: Rennurb. Reserve Fund and Undivided Profits Branches New Bank, Limited Burma, Ceylon, £785,794 Straits Settle York Agency. R. A. Edlundh, 64 Wan Street NATIONAL BANK OF INDIA limited Bankers to the Government in British East Africa and Uganda. Head Office: 36, Blshepegate, London, E. C, Branches in India, Burma, Ceylon, Kenyr Colony and at Aden and Zanzibar. 39'CORNHILL, Telegraphic Address, Udteco: London. Incorporated by Royal Charter. Offers every banking facility for transaction with Greece, where it has been established for 80 years, and has Branches throughout the Capital Authorized St Subscribed 310,MO,000 Country. Reserve Fund—— Also at Alexandria, Cairo, Ac., in Egypt Head Office: Basildon House, Moorgate Street. LONDON. £. C. S. India, The Union Discount Co. of London, Limited Ionian in meats, Federated Malay States, China, and Mauritius, total l«,2l5,70=£iyJM72 Spanish and European banking business conducted* .£1,569,999 £759,999 £75#,iff . St., E* C. 3 classes of Argentine, London Capital Authorized and Subscribed. Cental Paid Up.... BRUSSELS, Belgium HEAD OFFICE, BUENOS AIRES London Office, 7 Fonchurch BUSINESS BANKING TRANSACTED. Established 1879 London Office: 18; Provincials Kingdom. Lyons asgetiated Office, Credlto Fund Si Australia and elsewhere. dead di Lire 815,600,001 " 41,090,009 Deposit and Current Accounts (May 31, 1919)——— "2,696,909,008 Commercial Banking Company htirnational Banking Corporation 60 WALL STREET. NEW YORK CITY. of Sydney Ettablished 1884. Italiana Capital Fully Paid Up Reeerve THE incorporated the are Sectota Banearia Italiana lead Office: 71 CORNHILL, LONDON, E.C. Capital Paid Up—— 5,000,000 ... 5,000,000 85=£l STERLING. NOTICE IS HEREBY , RATES OF INTEREST GIVEN allowed that for Subscribed Capital —£3,000,600 Paid-up Capital —£1,509,068 i Reserve Fund———£3,999,608 1 The Bank conducts every description of banking and exchange business. the money Clermont & Co. deposit are as follows: on At Call, 5 Per Cent. BANK OF BRITISH WEST AFRICAJ.TD Authorized Capital 310,080,006 Subscribed Capital....—.— 7,289,009 Capital (Paid Up) 2,900,090 Surplus and Undivided Profits 1,295,569 Branches throughout Egypt, Morocco, West Africa and the Canary Islands. —— At 3 to 7 Days' BANKERS Notice, 5)4 Per Cent. The Company discounts approved bank and acceptances, receives money on de¬ posit at rates advertised from time to time, and grants loans on approved negotiable securities. mercantile CHRISTOPHER R. - Xlverpool Office, 25 Water Street APPLEBY, Agent. 100 Beaver St., New York The National Discount LONDON, E. C. Cable Address—Natdis London. Capital ...... Paid-up Capital.— 8% Convertible Gold Notes English Scottish and Australian Bank, Ltd. Address: 5 Gracechurch St., E. C. Head Office: London, E. C. 8. Subscribed Capital 35 CORNHILL Subscribed Cable Address: "Glerment" Authorized Capital Reserve Fund Company, Limited Aetna Petroleum Corporation Central America NUGENT, Manager. Bead Office, J 7 & 18 Leaden hall St., London, E. C Manchester Office, 106-108 Portland Street B. GUATEMALA, ..321,166,025 ......... Reserve Fund.....—... 4,233,325 2,500,000 • £3,000,606 —685,060 1,078,875 8 0 0 0 I Paid-up Capital — — 639,437 10 9 Further Liability of Proprietors. 639.437 18 0 Remittances made by Telegraphic Transfer, Bills Negotiated or forwarded fer Collection. Banking and Exchange business of every ds •CTipa°n (85=£1 STERLING.) Circular on Request NOTICE Is hereby given that the RATES OF -INTEREST allowed few money on Deposit as are 5% per annum at call, Jones & Thurmond 18 Broad St. New York, N.Y. Phone: Broad 7412 Hong Kong & Shanghai BANKING CORPORATION follows: 6H % at 7 and 14 days notice. Approved Bank & Mercantile Bills discounted. Money received on deposit at rates advertised from time to time; ana fo i fixed periods upon specially agreed terms. Loan granted on ap¬ proved negotiable securitJe PHILIP HAROLD WADE Manager Paid up Capital (Hongkong Currency).. .H815,000,000 Reserve Fund in Silver (Honkgong Curr.) JEJ23,000,000 Reserve Fund In Gold Sterling—........ £1,600,000 GRANT DRAFTS, ISSUE LETTERS OF CREDIT. NEGOTIATE OR COLLECT BILLS PAYABLE III CHINA, JAPAN, PHILIPPINES, 8TRAITS SET¬ TLEMENTS, INDIA. j. a. JEFFREY. Agent, 36 Wall St., New York Dec. 181920.] VII CHRONICLE THE ^foreign Jfotrtgtr Jforelgtt London, E. C. Banque Nationale de Credit FISCAL AGENTS FOR * Capital 500,000,000 frs. frs.2,400,000,000 Capital, fully paid £3,000,000 £1,663,270 4 LIT. In Branches Rhenish Provinces the GENERAL BANKING BUSINESS THE NATIONAL PROVINCIAL AND UNION BANK OF EN6LAND Limited ($5==£1.) Office, Milan, Italy London Office, Old 1 ESCRIBED CAPITAL 165 Broadway Broad Street, ID-UP CAPITAL E. C. 2 RYE PUND Constantinople 80 branches in UNION Italy, at all the prim cipal points in the Kingdom AFFILIATED INSTITUTIONS COMMERCIALE Marseille and ITALIANA De (France) - with Bucareat and branches BANQUE FRANCAISE L'AMERIQUE Sao Paulo, BANCA and DELLA de & ITALIENNE SUD— Paris, DU Rio Janeiro SVIZZERA and Aires, ITALIANO—Lima SOCIETA ITALIANA CIALE—Vienna, BANCO FRANCES and Every Description of Banking Business branches CREDITO Trieste England Wales ROTTERDAMSCHR ITALIANA—Lugano and DI $3#.1®«.20U BANHVEREENIGINO branches branches BANCO Winterthur, Basle, Geneva, Lausanne, &o, POUR Buenos • ZURICH , St. Gall, UNGARO-ITALIANA—Budapest - 210®.671,® 88®,034.1 Offices in num.rou* and . BANCA COMMERCIALE ITALIANA E ROMENA— BANCA • - 15, Bisiopsgate, Loudon, England, ITALIANA E BULGARA branches - Head Office: Banques Suisse* branches BANCA COMMERCIALE —Sophia and WILLIAM ST., _LIT.4,371,970,562 Head Paris, KING 7 156,000,000 New York Agency, BANCA AGENCY LONDON, E. C., 4, ENGLAND. 400,000,000 ..LIT, SURPLUS AND 6 300 Branches in France SPERLING & CO., INC., CAPITAL Fund LONDON PARIS DEPOSITS Law Egyptian Head Office: NBW YORK AGENTS COMMERCIAL ITALIANA under Established June, 1898, with the exclusive right to Issue Notes payable at sight to bearer. Reserve Hydro-Electric Companies BANCA Office—Cairo. Head 90,000,000 Deposits and frs. Surplus Public Utility BROADWAY. EGYPT of Basildon House, Moorgate St. 128 BANK NATIONAL SPERLING & CO. DE CHILE—Santiago, The Foreign Exchange, Documentary Credit*. branches Amsterdam Rotterdam COMMER¬ Hague Valpar¬ aiso. BANCO'FRANCES E ITALIANO DE COLOMBIA— Bogota. CAPITAL UP PAID Fr..70,000,000 " RESERVES 15,000,000 CAPITAL AND RESERVE F.105,099,000 FUND COLLECTIONS STJUOUI BANK OF SOOTH AFRICA, Ltd HEAD OFFICE. Avtberized SWITZERLAND LONDON. E. C. $31,26®,00® Paid-up Capital &. Reserve Pund. $18,812,f®® Government, State and H. 88 and Agencies STOCKS AND SHARES BONDS throughout for investment THE COMMERCIAL BANK OF SCOTLAND, LIS MACINTYRE, A*ent Wall St.. Established 1810 New York Apply to _Aleo representing The Bank of New South Wales with OF PURCHASE AND SALE Municipal $166,126,411 Resources Over 840 Branches Africa. Bents W. CREDIT FOREIGN EXCHANGE J50,W0,0M Capital Subscribed Capital Tata! LETTERS OF Head SWISS BANK CORPORATION of SOUTH AFRICA, Ltd. over ———•—- £5 paid..£1,356,666 of £1 each fully pald..£ 506,666 250.000 "A" shares of £20 each 600.000 "B' shares Deposits—.£36,671.1*3 MAGNUS IRVINE, B««. London Office—62 Lombard Street, E. O. Glasgow Office—113 Buchanan Street. Drafts, Circular Notes and Letters of Credit Issued »«4 every description of British, Colonial and Foreign PanMifig and Exchange business transacted. New York Agent®—American Exchange Nat. Bank £1,600,000 Reserve GENEVA ZURICH Branches all ..£5,566,666 Paid up— $1,758,666 BASLE The NATIONAL BANK Office—EDINBURGH Capital (Subscribed) branches throughout Australasia. Switzerland and in London Over 500 Branches In Africa ALEX. ROBB. Gen. Mgr ... Total Assets exceed - $430,000,000 Arnold Gilissen&jCo Lincoln Menny Oppenheimer Damrak 80-81 Often to American banks and bankers its superior AMSTERDAM facilities for the extension of trade and com¬ merce Cable Address between this country and Africa. : THE ROTTERDAM New York Agency R. - - HAGUE 10 Wall St. Established E. SAUNDERS, Agent. FOREIGN up Funds Reserve frs. 100,000,000 frs. 30,000,000 Bank of Scotland KONIG Royal £2,000,000 £39,114,127 Deposits - St. Andrew Square, London Office Glasgow Office - Odftomentary Business, Letter® of - - Every Description of Travellers' Letters of Credit OP KONIG BROTHERS, Throughout Scotland. British, Colonial and Foreign Banking Business Transacted. Credit Commercial and Exchange Square Agent: Thomas Lillie. BUSINESS. CO. 3 Bishopsgate, E.C.2 ... 172 Branches BANKING Wright. Manager: Wm. Wallace. Geneva, Glarls, Kreuzlingen, Lugano, Foreign Exchange & NEW YORK Edinburgh Cashier and General Manager: A. K. Lucerne, Neuchatel, St. Gall. 160 Pearl Street, £1,082,276 Head Office Br*neh©« at Basle, Berne, Frauenfeld, BROTHERS Incorporated by Royal Charter, 1727. Rest and Undivided Profits OFFICE Zurich, Switzerland GENERAL FOREIGN EXCHANGE 1856 Paid-up Capital HEAD INVESTMENT SECURITIES EXCHANGE SUISSE Established Capital paid FRANKFORT-o-M., GERMANY Cable Address "Openhym" 1871 BANKERS AND STOCKRBOKERS CREDIT BANKERS Achilles-Amsterdam Correspondence Invited. LONDON and NEDERLANDSCh'E HlNDEL-MAATSCHAPPl ROTTERDAM THE nil [VOL. 111. CHRONICLE Putters anti Profeete Gutstitst fitta §otb CHICAGO CHICAGO ST. LOUIS Greenebaum Sons A. G. Edwards & Sons ." V ■ . "'v. ■. '■'.' , '' ■'■. ■...:•;. ■' , ;, ■ ;\' lildenSJilden Banlr andTrust Company INCOHPOHATZD Investment Southeast Corner La Salle and Madison Sts. Bonds Members 410 Olive St., La Salla Street 108 So. CHICAGO $2,000,000 Capital and Surplus, Stock Exchange Louis St. BANKING GENERAL New York Stock Exchange 6% CHICAGO FIRST MORTGAGE BONDS ST. LOUIS Suitable for Estates, Trustees and Individuals Write for Bond Circular C 26.. Oldeet Banking House In Chicago. MUNICIPAL INVESTMENT BONDS BONDS MUNICIPAL 111 First. Mortgage BONDS CORPORATION Monroe St. W. CHICAGO Corporation Bonds INDUSTRIAL & STITT SCOTT A State Bank Short Term Industrial PREFERRED STOCKS Note Issues Hyney, Emerson & Co. 3» South Lorenzo L Anderson & Company SIS N. 8th A. O. Slaughter & Co. St., St. Leuie Members ■unlcipal and Corporation Bonds TIMBER Chicago Stock Exchange Chicago Board of Trade based always upon 110 WEST Ohlcage Beard ef Trade St. Leuia Merchants Exchange St. Leuls Gotten Exchange St. Louis Stock Exchange MONROE STREET Charles W. Moore 39 South New Yerk Philadelphia 5^% COMPANY & 1937-1941-1944 Population SALLE STREET 5.30 The Provident CHICAGO Members St. Louis Stock Exchange Savings Bank & Trust Co. Bond TAYLOR, EWART & CO. CO. Department O. CINCINNATI, INVESTMENT BANKERS 105 South La Salle Street Investment Securities CHANNER & SAWYER CHICAGO INVESTMENT Iff OLIVE ST. 300,000 District Yield Price SHAPKER, WALLER & CO. 184 SOUTH LA ST. LOUIS STIX & DistrictTOhio Bonds Interest June and Dec. 1—New York Formerly Member* St. Louis Stock Exchange Broadway Miami Conservancy Due SHAPKER Stock Exchange $75,000.00 St. Leuls BONDS Corporation HARK C. STEINBERG & CO. m N. CINCINNATI Salle Street La Municipal and LOUIS SERVICE York so. Michigan Av„ Chicago Chicago ST. LOUIS, MISSOURI Membert New 332 INVESTMENT SECURITIES INVESTMENT BONDS ST. underlying assetc Powell, Garard & Co. SMITH, MOORE & CO. OLIVE ST., expert verification CHICAGO, ILL. William H. Burg BONDS New York Stock Exchange - New York Stack Exchange New Yerk Gotten Bxafeamge ■anodes Smith CHICAGO La Salle St. ST. LOUIS SECURITIES Municipal Railroad and Public Union Utility Bonds Trust Bldg., CINCINNATI, OHIO SPRINGFIELD, ILL. John Burnham Hatheny, Dixon, Cole & Co. High Grade Investment Se¬ curities, Ridcely-Farmers Bank Bldg., SPRINGFIELD. Convertible Note DEALERS Issues, Bonds, Bank Shares, Unlisted Securities. ILLINOIS. 41 WE WILL BUY South La IN INVESTMENT SECURITIES Salle St. IRWIN, BALLMANN&CO. CHICAGO Springfield (Illinois) Pleasure Drive* way Ohio Securities—Municipal Bonds New York Stocks and Bonds Co. 828-330-332 Walnut Str & Park District 4s CINCINNATI, OHIO F. WM. KRAFT, Lawyer BUFFALO Specializing In Examination & Preparation ef Slocnm, Eckardt & Company County, Municipal and Corporation Bonds, Warrants and Securities and FR I EDLANDE,R EDGAR DEALER IN Proceedings Authorizing Same. Rooms 617-520, 111 W. Monroe St., Harris Trust Building INVESTMENTS Cincinnati Securities OHIO CINCINNATI CHICAGO, ILLINOIS 420 Ellicott Square TOLEDO BUFFALO, N. Y. FEDDE & PASLEY TUCKER,ROBISON &CO. JOHN T. STEELE Successors Certifieb BUFFALO, N. Y. public accountant!! 55 Liberty St., New York SPECIALISTS IN GEORGE W. LESSER STOCKS AND BONDS Public Accountant Investigations, Estate Accounting, Income Tax Returns BUFFALO N. V 1878. TOLEDO, OHIO MYER, JR 352NASSAUIST., NEW |YORK A Udits kot Square Sons Toledo and Ohio Securities Gardner Building, Certified $ A Municipal, Railroad and Corporation Bads . Buffalo and Western New York Securities T. to Robison Jr. Bankers—Established Government, Mnnlclpa and Corporation Bonds IRVING David Telephone Rector 5441 Graves, Blanchet & Thornburgh MUNICIPAL BONPS GARDNER BUILDING TOLEDO. OHIO Dec. 18 1920.] THE IX CHRONICLE JBanfeem anb JBrofeenf ©utsfte J?eto Sort MICHIGAN MICHIGAN iSobbn, gtoan & Cbtoarba Co. Mansbers of Detroit Stoek Exchange PITTSBURGH GORDON & COMPANY Members Detroit Stock Exchange INVESTMENT BANKERS Members Pittsburgh Stock Exchange Charles A. Parcel Is & Co. Carried Union Bank Building. In All Markets. Inquiries Solicited Stocks Conservative Margins on INVESTMENT SECURITIES PITTSBURGH,SPA. Phone Court 3264-5 810 Congress DETROIT, MICH. Bldg., PENOBSCOT BUILDING, DETROIT, MICH. LYON, SINGER & CO. A. J. Hood INVESTMENT BANKERS & Company (Established 20 Years) CmBMonv..lth Bldg., Members Detroit Stock Exchange Richard Brand Company PITTSBURGH MICHIGAN SECURITIES Securities of Pittsburgh District BOUGHT—SOLD—QUOTED Pennsylvania Municipal Bonds Specializing Specialize in Michigan Stocks and Bonda PENOBSCOT. BUILDING DETROIT Detroit Securities We invite your inquiries 1721-3 Dime Bank Bldg., Detroit Geo. W. Eberhardt & Co. OLIVER BUILDING, PITTSBURGH Stocks, Bonds, Grain GORDON, FORTIER & CO. WHITTLESEY, McLEAN & CQ. and Provisions Investment Members New York Stock Exchange Chicago Board of Suits Trade 1613, Dims Bank Building Active Members of Detroit Stock Exchange Telephone Cadillac 5050 ^ A. MASTEN E. Municipal Bonds Corporation Bonds Preferred Stocks Members Pittsburgh Stock Exchange Members Securities & CO. MICHIGAN DETROIT DETROIT 2054-56-58 Penobscot Bldg., Established 1891 > [New York Stock Exchange Boston Members Stock PROVIDENCE Exchange Pittsburgh Stock Exchange Chicago Stock Exchange Chicago Board of Trade New York Cotton Exchange 323 Fourth Ave., FENTON, DAVIS & BOYLE BODELL & CO. Pittsburgh, Pa. Branch Office: Investment Bankers STREET 10 WEYBOSSET Wheeling, W. Va. Chicago Grand Rapids Detroit PROVIDENCE . INVESTMENT Company NEWARK, CO. MUNICIPAL BONDS I •T GRISWOLD ST. CONSERVATIVE DETROIT INVESTMENT SECURITIES PITTSBURGH, PA. List upon request CITY KANSAS N.J[^ & HIGBIE KEANE, BONDS UNION ARCADE BUILDING 190-395 Boston New York Carson Dick & KAY & CO. Inc., F. M. CHADBOURNE & CO. STREET & COMPANY INVESTMENT BANKERS INSURANCE BUILDING FIREMEN'S NEWARK, N. J. P«nob>cot Municipal & Corporate Bonds Local Kansas TEXAS Securities DETROIT, MICH. Bid,. Members Detroit Stock Exchange Missouri City J. E.JARRATT& COMPANY GEORGE M. WEST & COMPANY INDIANAPOLIS Investment Fletcher American Company Bankers Established Municipal Bonds I INVESTMENT BANKERS INDIANAPOLIS San Capital Write as or Antonio, Texas, offerings DETROIT, MICH UNION TRUST BLDG. $1,500,000 for bids or Indianapolis * « 1893 Members Detroit Stock Exchange on any Indiana Security. Statistical Information Furnished. DUNN & CARR Investment Securities W. A. HAMLIN & CO. Members Detroit Stock Exchange Union BREED, ELLIOTT & HARRISON Nat. HOUSTON. . TEXAS • Motor Stocks, Public INDIANAPOLIS 1010 naslanBti Detroit Chicago Milwaukee . Bank Bldg. Utilities & Oils DETROIT, MICH. Penobscot Bldg., MACON Investment Securities Municipal Bonds Indiana Corporation Securities V. M. DAVIS & COMPANY Bonds Southern Municipal Joel Stockard & Co., Inc., INVESTMENT BANKERS AND NEWTON TODD Local Securities and Kadiana Corporation Guaranteed Stocks GEORGIA 4ACON Bonds and Stocks Municipal, Government & Corporation Bonds Members Detroit StockJExchange Penobscot Bldg. ■ DETROIT • Cherry 2609 INDIANAPOLIS «1S Lemcke Bldg. NORFOLK, VA LOUISVILLE JOHNSTON & COMPANY MOTTU & CO. HARRIS, SMALL & LAWSOR Established 1892 INVESTMENT INVESTMENT SECURITIES 60 * Paoif Jeues Bldg. LOUISVILLE, KY. SECURITIES NEW YORK NORFOLK, VA. INVESTMENTS Broadway . 44 CONGRESS ST.. W. DETROIT CHRONICLE THE X [VOL. 111. Ranker* anb Jfrofctra &ut*ibt &eto gorfe DENVER PACIFIC COAST PACIFIC COAST Howard Throckmorton Pacific Coast Securities CALIFORNIA SECURITIES Boettcher, Porter BONDS Government & of MUNICIPALITIES AND Company Bonds Municipal CORPORATIONS Corporation INVESTMENT BANKERS having substantial assete San Francisco and earning power, Alaska Commercial Building DENVER Quotations and Furnished Information on Pacific Coast Securities Established LOS 1853 SUTRO & SAN ANGELES PASADENA FRANCISCO WESTERN SECURITIES CO. Sugar Stocks INVESTMENT BROKERS San Francisco 6fi Montgomery St. Specialty a Members San Francisco Stock GREGG, WHITEHEAD & CO. and Bond Exchange Bla&kenbora-Hanter-DiiliB F. M. BROWN & CO. DEALERS IN Investment PORTLAND, BONDS CORPORATION Dr\\lF\Q MORRIS AND DISTRICT BROTHERS, Inc. UVJlHUD THE PREMIER MUNICIPAL BOND HOUSS FRANCISCO, CALIFORNIA CAPITAL ONE MILLION DOLLARS and Government LOS ANGELES California Securities ORE. MUNICIPAL 818-815 First National Bank Building MunlclpalJjBonde FRANCISCO SAN Established PASADENA SAN over a Quarter Century DIEGO Morris Building PORTLAND, OREGON • No. 8, Central Building Aronson and Bankers DENVER Company | Municipal and Corporation SAN COLORADO WILLIAM R. STAATS CO. SEATTLE,iWASH. . Company Lot Angeles, We specialize in California Municipal & Corporation California HALL & COMPANY BONDS INVESTMENT BONDS CLEVELAND DRAKE, Rl LEY & THOMAS The Gondiing-Jones Company Looal and Paelflo Coast Securities Van Nuys Building PORTLAND. OREQOS LEWIS BUILDING LOS ANGELES STOCKS-BONDS-NOTES MINNEAPOLIS Private Wirea^Coagt to Coast BANGOR BUILDING, CLEVELAND CorrwpoudcntsILogan and Bryan m A. H. Woollacott & Co. OTIS & COMPANY Stocks, Bonds, Grain, Cotton Stevens&-@o. ' 828-268 I. W. Hellman Investment Bankers LOS ESTABLISHED Building U)10 Kiinxcipal railroad ANGELES Members of New York, Cleveland, Chicago, Detroit and Columbus Stock Exchanges. CORPORATION BONDS New York Cotton Exchange. Chicago Board of Trade. COMMERCIAX PAPER-/ Detroit Cincinnati Columbus Toledo Denver Colorado Springs AUGUSTA Akron Young, town Stocks Bonds Acceptances California Securities LOS ANGELES CALIFORNIA JOHN W. DICKEY Augusta, Ga. SHORT TERM NOTES RITTER COMMERCIAL TRUST Unincorporated S£LEVELAND §90 Euclid Ave. BUFFALO Niagara Life Bldg. A. E. LEWIS Southern Securities & CO. Municipal, Public Utility, Railroad and Corporation Established 1886. BONDS of the PACIFIC COAST Security Bldg. Los Angeles, Cal. WM. E: BUSH & CO. THE KLIPFEL - WASHBURN - BERKLEY CO. R. H. MOULTON & COMPANY INVESTMENT SECURITIES Snd Floor National CALIFORNIA MUNICIPALS Title Insurance Building, City Bldg. CLEVELAND, O. Dayton Warren LOS ANGELES American NatT Bank Bldg., Augusta, Ga. SOUTHERN SECURITIES COTTON MILL STOCKS San Francisco Bucyrus SPARTANBURG. MAX I. KOSHLAND Listed - Unlisted - Inactive Stocks & Bonds Pacific Coast Securities A. M. LAW & Member Bldg. CO., Inc. Exchange Stocks and Bonds Mills Building SAN FRANCISCO ALBERT FOYER S, C. DEALERS IN San Francisco Stock and Bond Leader News 5T.PAUL MINNEAPOLIS TORRANCE, MARSHALL & CO. CLEVELAND Boston* Southern Textiles a CLEVELAND, O. Specialty SPARTANBURG, S. C. Hunter Glover & Company CHAPMAN DE WOLFE CO. MONTGOMERY 851-863 SAN Investment Bonds and Stocks Short Term Notes CLEVELAND Montgomery Street, FRANCISCO, CALIF. Stocks and Bonds Information and Quotations on B. W. all Pacifle Coast Securities Members Baa Francisco Stock & Bond Exchange SOUTHERN Strassburger INVESTMENT SECURITIES Mentgamerv, Ala Dec. 181920.] THE CHRONICLE XI Panfcert anfc JBtofeers ©uttfte iieto ALABAMA PHILADELPHIA PHILADELPHIA marx & company Parsly Bros. &. Co. BANKERS BLAJSTKJEItS MEMBER8 BIRMINGHAM, . . . Graham. Parsons & Co. 4S9 CHESTNUT ST. Southern Municipal and PINE NEW ST. YORK Investment Securities Investment Corporation Bonds II PHILADELPHIA PHILADELPHIA STOCK EXCHANGE ALA. Securities Deal in CHATTANOOGA and Purchase Issues of 1421 CHESTNUT STREET MUNICIPAL PHILADELPHIA lewis burke & co. BONDS. BONDS, NOTES AND PREFERRED STOCSl of LOCAL AND SOUTHERN RAILROADS, THAYER, BAKER & CO. SECURITIES INDUSTRIAL . Ibbmi Building UTILITIES AND CORPORATIONS of ESTABLISHED VALUE CHATTANOOGA Cable Address "Graco," Philadelphia BOSTON New investments England Industrial Securities Commercial Trust Yielding G%% to 8% Bldg., Boles &Westwood PHILADELPHIA Members Philadelphia Stock Exchange j. murray walker Established Devonshire Street NEW 1865 Boston ORLEANS Investment 410 Chestnut St. Philadelphia Securities Members New York and Philadelphia Stock Exchanges We will buy and sell the following equipments : Six Per Cent LiMl Tito BMBnj, - PUIUBELPHU ■ Chesapeake & Ohio 6 Hs-~ -1927-30 Southern Municipals Canadian Pacific 6s Telephone Loauit 4721 1926-30 Canadian Northern 6s.. 1926-30 Michigan Central 6s_ 1926-30 MILWAUKEE Short Time Notes Commercial Paper EDGAR. East RICKER Water and &. Masen CO. em.0lark§€o. Streets MILWAUKEE, WIS. Preferred Stocks BANKERS Specializing Acceptances WISCONSIN CORPORATION ISSUES 321 Chestnut St., Philadelphia Established 1837 Financing of Milwaukee Hibernia Securities Company (Incorporated) HibeTnia Bank - Stock Exchanges Investment Securities Building Bought and Sold. AA.£Cowrae.Cgi New Orleans New York Office Members New York and Philadelphia and Wisconsin Industries. 44 Pine St. First Wisconsin ierabers Philadelphia Stock Company Exchange INVESTMENT BANKERS Investment Securities Land Title Building PHILADELPHIA MILWAUKEE WISCONSIN New York Telephone Canal 4841 BALTIMORE Pennsylvania Tax Free R. Lancaster Williams & Co., Inc. INVESTMENT SECURITIES PAUL & CO. Second Ward Securities Co. tembers Philadelphia Stock Exchange Saaond Ward Savings Bank Bldg. Equitable Building. BALTIMORE Bonds 1421 MILWAUKEE Chestnut Street PHILADELPHIA MARYLAND 108 So. La Salle St. CHICAGO Scott & S , and it was said that "the about next and ex¬ off the attackers after a strenuous drove was determined effort was the police, but Sergeant Beatty, morning not a window was left whole in the barracks, while the walls were filled with bullets. Sergeant Beatty, in repelling the attack, was to have been severely burned about the arms." Cloyne, in County Cork, and at various less serious disorders occurred. The Rev. Michael said At other points, O'Flanagan, acting President of Fein, requested Premier Lloyd George for the Sinn time, "in which to consult with Eamonn de Valera Griffith respecting the endeavors now and Arthur being made to bring about a truce in Ireland." It was said that "Father O'Flanagan made this request which Mr. proposal look¬ stroyed by fire." The property loss was tween $10,000,000 and $15,000,000 in the early ing to a truce, said the British Government did not lag behind any section of the Irish people in the advices and was not changed in later dispatches. largely de¬ placed at be¬ ground and that other portions were In Press account it was said that the Associated conflagration followed an ambush of the mili¬ "the tary at Billon's Cross, Saturday night, in which four killed and many wounded." Accord¬ ing to an early official report, the Cork City Hall, the Carnegie Library, the Corn Market and eighteen other buildings in that section were destroyed. Pri¬ vate residences in various parts of the city were persons were gram In another cable¬ destroyed also. said to have been direct from Cork to the New York "Times" the was made that "all the buildings were statement Mayor of Cork telegraphed the Lord Lord The Cork unable was The London correspondent of the begged for help." New York "Tribune" declared that in "all the long crimes, reprisals and counter attacks in of series fire brigade in with the outbreak and to cope Ireland, there is no parallel for to-day's disaster, the He added that "to-day came the Lloyd burning of Cork." It crisis. was Lloyd George, responding to the first Ireland should enjoy the blessings that desire of and prosperity, and was prepared to offer fa¬ cilities for a complete discussion of the whole situa¬ peace tion." Wednesday that de London received a rumor on Valera likely to arrive in that city in a few was find no difficulty days, and that "probably he will landing." about In official circles it was stated » tendency to discredit the report that "there was a Harry Boland, de Valera's secretary, - altogether. was quoted in New York Thursday as saying that' "in hiding in this country," but the Irish leader was substantial, occupying large areas." Mayor of Dublin "stating that the reply to a letter from the Premier, in in the first development since George made his announcement of a dual Irish pol¬ "might consider returning to Great ed safe conduct Muriel to have said, McSwiney was reported don't know where he not left this Britain if grant¬ Mrs. by Premier Lloyd George." is, but I am quite sure In a London cablegram yes¬ country." said to have been terday morning attention was technically called in official circles to the fact that Valera de against the law and is "offended has liable to be arrested in this In the country" [England] of Commons Wednesday House "I he has . evening, Law, spokesman for the Government, icy of coercion and reconciliation." He said also that Andrew Bonar "in the announced that the "Black and Tans" had been or- opinion of many in London to-night it is a body blow to those who have had the statement of that hopes of In still another in Ireland." an early made that "the devastated was city embraced five acres." area There were re¬ ports also that pillage and incendiarism were in¬ dulged in, even by men likewise made that was in uniform. The assertion "eye-witnesses of the burn¬ ing of Cork graphically relate how scarfs removed loot from the men masked with flame-enveloped shops." Naturally this horrible affair in Cork came up early discussion in the House of Commons. it was There were taken were hand early as on Rev. In a was Michael O'Flanagan had been cablegram from London Thursday evening it units from Cork has been tary fires in that up its conclusions." same Lloyd George of peace plans drawn by the Labor party. that Other advices evening told of the presenta¬ "the It Cork was fire said to have been re¬ started by the Announcement asserted under complete auxiliary police—the Black and Tans." military and that it was All of the trouble in Ireland this week was not fierce fight took place between police for the possession of Cam- lough, South Armagh, police barracks. In the prepared to meet attacks elsewhere in Ireland. the origin of the city Saturday night and Sunday has not indignantly denied by Sir Hamar as a completed, but the mili¬ investigating commission tion to Premier Cork, to the made public. reported that "withdrawal of 'Black and Tan' military forces representing the Sinn Feiners and to-morrow" day the text of Premier Lloyd George's reply by was Common It was stated also that earlier in the was Tuesday that Cork of House in the [Thursday]. from London the control of the Government confined to taken up yet made public This made In fact, amended by the House of Lords, would be as Monday night. as Greenwood, Secretary for Ireland. was for Bill, imputations in the House that the fires started Crown. in and that "the Irish Home Rule peace 'dered out of Cork, cablegram from Cork According a • was cablegram from Dublin yesterday morning assertion was made have been resumed in [Thursday] on that good authority. certain the lines on "peace negotiations Ireland, it is learned to-night which the It is difficult to as¬ intermediaries are operating owing to the reticence of all engaged, but Dec. it 181920.] THE CHRONICLE is understood that high church dignitaries, in¬ cluding Archbishop Clune of Perth, Western Aus¬ tralia, and the Bishop of Killaloe, Mgr. Fogarty, are prominent among those continuing their efforts to bring about settlement." a 3359 the delegates expressed their belief to-night [Thurs¬ day] in the possible abandonment of the conference of experts some unless the Germans constructive ideas payment of reparations. tinue to-morrow There has been less furore in New York London, Paris and the concessions for immense tracts over of land in Russia which Washington B. Yanderlip has claimed that he secured from the Soviet Govern¬ ment of about a that country. week He arrived in New York and has proceeded to Los An¬ ago geles, without going to Washington, nounced he intended to do. to the national the capitol resumption it as The purpose was an¬ of his trip said to have been to urge was of trade relations United States and Soviet Russia at between the to newspaper representatives in London, except that he modified certain of his earlier assertions somewhat. "Guardian" sent information It seems that the Manchester cablegram to M. Tchitcherin for a regarding the concession which Yanderlip claims that he had secured. referred to Leonid was trade envoy of Mr. Mr. The paper Krassin, Russian Bolshevist in London. Tchitcherin, The latter, speaking for said to have "confirmed the claims was Yanderlip in connection with vast Russian concessions," but to have "emphasized that it was a good business proposal for the Russian Soviet, since, according to the terms of the concessions, in what¬ benefits ever the It Soviet are gained by the American syndicate Government will gain comparatively." pointed out that while in London Mr. Vander- was lip said he had made "a definite, unqualifed under¬ standing for the exact conduct of his business in his own which would be along the lines of Ameri¬ way, business, and the can same as now necessity of taking up reparations solution immediately." It was add¬ ed that at the Premier House of Commons still were Lloyd George enjoyed by the announced in the Tuesday that negotiations on pending with Krassin and that he had hopes "of concluding a trade agreement between Great Britain and Russia." It became known, how¬ ever, that "meanwhile Krassin has amended the Rus- sian proposal and that it will be submitted to the ■ * . * President of the British Board of Trade." don most of the afternoon in go emphasized the deadening effect upon German industry of the demoralized exchange situation, but did not give the constructive ideas the members of the conference It was proposed by Krassin said to have been rumored Thursday afternoon that the negotiations likely to be broken off. were The British second Brussels its sessions in that that the German city financial on conference Wednesday. delegates, among It small gain in income chequer balance whom began are said Dr. Walter Simons, the Foreign Minister, and Sigmund Bergmann, Under-Secretary for Finance, were ex¬ pected to bring "a personnel equalling the combined staffs of Allies." the A dispatch from stated that "the United States but Roland W. Boyden, who was was repaid, arrived attend, the unofficial repre¬ coming to the present conference." dispatch stated that the German delegation It numbered 27. The Wednesday evening. Expendi¬ a week Of this total, ago. revenues contributed £14,791,000, against £16,806,000, savings certificates £850,000, against £620,000, and advances £7,850,000, against £55,150,000. Sundries yielded £369,Last 000. £130,000. of week total the Treasury bills £62,072,000, which 812,000 week from source was sold to the amount were compares earlier. this with sales of £93,- Repayments were only £50,961,000; hence the volume of bills outstanding was again augmented, this time to £1,137,604,000, a against as Sales of £1,126,729,000 in the preceding week. Treasury bonds were also smaller, namely £815,000, against £2,050,000 last week. advances floating debt which compares In the to Temporary £260,264,000, as £268,414,000 the week previous. pared with total lowered were com¬ The aggregates £1,397,868,000, now with £1,395,143,000 the week before. corresponding week of 1919 the floating debt amounted stand at to £1,341,805,000. £2,555,000, as Exchequer balances contrasted with £2,365,000 week. Official discount rates at leading European centres continue to be quoted at 5% in Berlin, Vienna and Switzerland; 5Yi% in Belgium; 6% in Paris, Rome and Madrid; 7% in London, Sweden and Norway, In London the private bank 4^% in Holland. is firmer and advanced to 6 last week. sixty and ninety-day bills have 11-16@6%%, Money on changed from 4%%.' So far ascertain, open no as against 6J/£@6^% call in London has not been as we have been able to reports have been received by cable of market discounts at other centres. Brussels invited to September last, has forwarded notice Associated Press correspondent expanded £190,000. were £86,747,000, in comparison with £168,570,000 were The Bank of increase in gold showed A later a that the Ex¬ so £86,557,000 (against £169,555,000 for 4). Receipts from all sources was conference in not outgo, over national 11 indicated the week ended Dec. note circulation was of statement £15,307,000, against £65,336,000, while the total outflow, including Treasury bills, advances, Exchequer bonds and other items sentative of the United States at the first financial that he was for the week tures rate was Treasury financing for the week ending Dec. and The hope to hear later." as¬ to the very heart of the guarantees demanded by in London pros¬ He last Great Britain." depicting the gloomy pects of his country's financial and economic future. The Lon¬ correspondent of the New York "Herald" serted that "the amendments opening session on Thursday, "Rudolph Havenstein, President of the Reichsbank, occupied International Harvester Co. in its branch in Rus¬ sia." con¬ [Friday], with the expectation that early date. an Yanderlip gave out several interviews, but his statements did not differ greatly made plan for the a The conference will the Germans will realize the the While in New York Mr. from those speedily advanced respecting said that "some of a England announces another large stocks, viz., £934,011, although was as expanded £825,000, total reserve gain of only £109,000/ Further reductions, shown in deposits, so that the propor¬ tion of reserve to liabilities was again advanced to however, 9.65%, were as against 9.34% ratio stood at 13^%. a week ago. Last year the In public deposits there was a ; THE 2360 of contraction deposits Other £3,023,000. brought down £413,000, while Government declined in loans were securities (£27,000) Threadneedle Street's gold recorded. was increase small A £3,585,000. £126,811,522, as against £91,- holdings aggregate [Vol. 111. CHRONICLE 498,847 in 1919 and £78,604,711 a year earlier. Note circulation is £131,233,000. Last year the total 5,778,651,000 marks. Note circulation showed no less than 400,236,000 marks. Notes fell increase of an of other banks declined 129,000 reduced 2,515,000 were marks, investments rrprks and other liabilities Irf advances there was an in¬ 9,713,000 marks. Other securities showed 313,512,000 marks. of crease of contraction a marks. 266,296,000 The Bank Reserves reports its gold holdings as 1,091,567,000, which stand at £14,024,000, which compares with £19,- compares with 1,090,300,000 marks a year ago and Note circulation has 649,227 in 1919 and £28,091,311 the year before 2,307,380,000 marks in 1918. reached the huge total of 64,284,400,000 marks. A that, while loans amount to £72,208,000, in compari¬ was £90,299,620 and in 1918 £68,963,400. son with £76,860,193 last year and £93,217,685 in year change in the Bank of There has been no 1918. 1918 it stood at 32,460,360,000 marks and in ago 19,175,460,000 marks. England's official discount rate, which continues at week they Last £764,810,000 and £723,770,000 a were We append a tabular statement of com¬ year ago. Saturday's return of the New York Clearing Last London the £670,589,000. totaled week the for through Clearings unchanged. 7% banks institutions House loan item parisons of the different items of the Bank of Eng¬ land return. This down to COMPARATIVE STATEMENT. 1917. V 1918. 1919. : 1916. Dec. 20. Dec. 16. Dec. 17. Dec. 18. Dec. 19. £ £ £ £ 90,299,620 68,963,400 45,037,670 £ 39,224400 21,538,293 28,868,255 36,926,245 53,580,815 .. 131,233,000 Circulation. 19,401,000 Public deposits Other deposits..... 126,070,000 125,311,507 143,884,583 129,127,809 109,007,255 42,187,508 Governm't securities 77,123,000 68,188,552 69,255,515 57,820,020 Other securities.... 72,206,000 76,800,193 93,217,685 95,113,836 104,680,907 Reserve notes & coin 14,024,000 19,649,227 28,091,311 30,984,826 Coin and bullion.._ 126,811,522 91,498,847 78,604,711 57.572,496 33,573,700 54,347,800 9.65% 13*6% 16.30% 18.70% 20.50% 7% 6% 5% Proportion of reserve to liabilities-— Bank rate. 5% /\ 6% ; ; there of $43,668,000 to $4,012,916,000. Government deposits which Reserves of member banks with the Bank in gold item, the increase this week being 982,000 francs. brought up total Bank's The gold holdings 5,577,925,292 francs last year francs the are thus comparing with and with 5,473,452,260 to 5,499,044,825 francs, before; of the foregoing amounts year francs 1,948,367,056 abroad in held were 1920, 1,978,278,416 francs in 1919 and 2,037,108,484 francs augmented by 32,228,000 francs. On the other hand, silver decreased 1,121,000 francs, bills discounted were reduced 81,975,000 francs, Treasury deposits fell in 1918. off During the week advances francs 42,806,000 and diminished by 325,863,000 were deposits were Note circulation general francs. registered the large expansion of 410,879,000 francs, bringing the total outstanding francs. This at this time last year in 1918. of war, On with contrasts to 38,330,955,370 up July 30 1914, just prior to the outbreak the amount was only 6,683,184,785 francs. Comparisons of the various items in this week's return with the statement of last week and sponding dates in 1919 and 1918 FRANCE'S BANK OF are as counted (not COMPARATIVE Changes Dec. 16 1920. In France Inc. Dec. J8.1919. Drc. 19 1918. Francs. Francs. Francs. Francs. 3,550,677,769 3,599,646,876 reserve trust augmented $100,000 to $9,360,000. was fell plus there total of was a a This week earlier. decline in Federal loss of $10,733,130, bringing the to $11,247,910, against reserves excess $21,981,040 the banks member Reserve institution chiefly due to was reserves and the with increase the in The above figures for surplus are on the basis of reserves above the legal requirements of deposits. 13% and do not include cash amounting to $97,370,held 000 by these banks on Saturday last. The better, in that from 37.8% to 39.1%. Federal Reserve Bank showing was the ratio of cash Total cash holdings reserves rose increased was reserve outstanding notes down came from reduced were $12,148,000 and $9,800,000. Bill $1,054,020,000 to $1,012,600,000. Seven per cent may vailing rate for call be said to have been the pre¬ money this week. During the 6% quotation last hour of business several days a was bulk reported, but it of the loans generally assumed that the made at the higher figure. that they said Borrowers was were experienced no difficulty getting whatever amount of money they needed, and it was even stated from day to day that the in 1,978,278,416 2,037,108,484 supply was well in excess of the demand. The time nearly nominal as before; loan market continued as 3,436,343,775 <1,948,367,056 982,000 No change Abroad kept in other companies Aggregate $5,419,000 to $542,844,000. As to sur¬ The depositories by State banks and Status as of for Week. Gold Holdings— STATEMENT. while reserves in own companies increased reserve), as $115,000 to $9,267,000. corre¬ follows: Cash vaults, however, gained $721,000 to $97,370,000 vaults of State banks and trust 37,378,431,650 francs and with 29,271,224,475 francs Federal Reserve $5,634,000 to $524,217,000. cut were reserves its In net time deposits only $8,408,000. decline of $11,213,000 to $250,636,000. was a gains in The Bank of France continues to report The exclusive of is were 1920. expected. as namely $619,000, but net demand deposits showed the large expansion BANK OF ENGLAND'S about was again reduced, though only slightly, was no changes in quotations were reported. The finan¬ are still disinclined, apparently, to cial institutions Total ..Inc. 982,000 Bills discounted—.Dec. Advances Note 5,499,044,825 5,577,925,292 1,121,000 Dec. Silver 264,468,495 272,160,113 5,473,452,260 318,501,391 81,975,000 3,255,843,298 1,194,308,246 971,916,166 32,228,000 ....Inc. 2,208,937,000 1,410,370,858 1,217,202,109 410,879,000 38,330,955,370 37,378,431,650 29,271,224,475 circulation..Inc. 42,806,000 110,075,000 82,179,497 General deposits—Dec. 325,863,000 3,542,464,894 3,182,251,112 2,451,676,996 in 41,378,275 Treasury deposits.Dec. of funds for the longer market was not disturbed the least by the preparations for the payment, Dec. 15, of the fourth installment of income and put out periods. on excess In its statement, issued as of Dec. 7, the Imperial Bank of Germany shows that was increased 4,000 marks. marks. There 529,000 total coin and bullion marks, while gold declined Treasury notes expanded 162,335,000 was another sensational cut in bills discounted, viz., 5,595,564,000 marks, while deposits a large amount The local profits money taxes. It was amount due in this revenue estimated that the district totaled approxi¬ According to unofficial esti¬ and $40,000,000 was the due date. As pointed out in mately $100,000,000. mates, not between $30,000,000 paid in on previous weeks, and as is well known in the financial and dividend district, there will be heavy interest Dec. 181920.] disbursements THE Jan. on of the omission of 1 thereabouts. or CHRONICLE DISCOUNT Because almost no declared. IN The railroads have of. care called cash extra new of maturities in debentures it may be as disposed of within during the week. time short a With continued slackening in the business of the country and further liquidation, the position monetary likely seems still become to easier. Dealing with specific rates for call have covered a loans money, on of 6@7% for both mixed range Discounted within FEDERAL RESERVE 17 BANKS 1920. maturing days (including 15-day col¬ Bankers' secured by— accep¬ banks' lateral notes) ! Treasury Liberty certifi¬ cates Boston tances paper bonds wise and secured member and banks for notes 5A maturing maturing within 91 to 180 90 days 6 days 7 7 6 Cleveland ... 6 7 5X 5A 6 5H 5H 6 6 6 6 6 7 7 6 7 7 0 7 v 6 ' t6 te to ....... 55* 6 h: 5H Chicago te 6 St. Louis.. ♦5H 5H 5H 6 6 6 6X Minneapolis 5A Kansas City Dallas San > 7 t6 0 \ 5H 6 6 t6 tfl Francisco and unsecured t6 ... Richmond live-stock Victory of New York...... Atlanta tural accep¬ disc'ted Other¬ edness Philadelphia Agricul¬ Trade tances Federal Reserve Bank of— bills 90 member large volume Two large issues of Standard Oil were THE indebt¬ rather a much assistance as willing to grants OF EFFECT DECEMBER being are likely that the Government will be for upon dividends January, which will have to be taken It is RATES considerable number of dividends a on industrial stocks, the total amount of money re¬ quired for the payment of dividends will not be as large as it otherwise would have been, particularly as 3361 5K 5A 6 6 6 6 6 0 • * 5H% on paper secured by 5 J* % certificates, and 5% on paper secured by 4?* % 5% certificates. i j; t Discount rate corresponds with Interest rate borne by certificates pledged aa collateral with minimum of 5% in the case of Philadelphia, Atlanta, Kansas City and Dallas and 5A% in the case of Cleveland.-Richmond, Chicago and San Franclsco. V ''".V ' /'-■'. ? Note.—Rates shown for St. Louis, Kansas City and Dallas are normal and . rates, applying to discounts not In of basic lines fixed excess for each member bank by the Federal Reserve Bank. Rates on discounts in excess of the basic line are subject toa H% progressive increase for each 25% by which the amount of accom¬ modation extended exceeds the basic line. * , collateral and all-industrial loans alike, as compared with flat rate of a Tuesday rates 7% week a Monday and ago. still fixed at 7%, this being the were high, the low and the ruling figure for all trans¬ actions on both days. On Wednesday slightly a eas¬ ier tone the developed and the call rate fell to 6%, though high was still 7% and renewals were negotiated at that with figure. Thursday's 7% still the renewal basis. shade firmer a range remained at 6@7% The call market put through at 7%, this having been both the imum and minimum figure. what was in easier being. not were available and brokers In max¬ some¬ look for conditions, at least for the time for fixed maturities the market money quiet and practically reported. now no important trades Opening quotations were firm nearly up were and un¬ impetus of 10 an was so exaggeration to at was a brisk inquiry rates a cents, to 3 53for Monday trading say ruled at last week. In keeping with this, has important of these banks entered the market liberal scale in end as buyers of exchange preparation for the forthcoming settlements. that Coupled with this exports have shown a and ninety days 7% for four, five and six months, as against on a year-* the fact was declining tendency of late, with the result that supplies of commercial Covering of shorts also played tions declined to 7@7J^% for sixty and re¬ Christmas, in addition to which London offerings slight easing and quota¬ Probably ening of the demand lately noted incidental to mittances for a lethargy that the sudden broad¬ was disbursements there a the levels however, prevailed recently in foreign exchange. changed, though with the completion of the Dec. 15 was or Subsequently, number of factors tended to break the the most On the market much of the time close to 3 44}^, very ran demand. light that it would hardly be complete standstill. prevailing surprising in view of the huge Decem¬ Later, however, more liberal monetary and under the was demands. 15 offerings was were inactivity in early dealings, sterling exchange turned strong rates light supply during the first half of the week which ber Funds brief interval of dulness and a was Friday and all the business on After the prices. about lighter than for were quite some time. part in advancing a Later in the week realizing sales brought slight recession, but this proved of short a 7J^@7J^% and 7J^@7^%, respectively, last week. duration and the close All-industrial money is for the week. being dealt in at about % of 1% higher than the rates just given. Mercantile has ruled firm but quiet with paper sixty and ninety days' endorsed bills receivable and six months' of names choice character still quoted at News that a of carrying on bank non-member bills. Both local and town institutions have been in the market Loans on demand against continue to be quoted at are as bankers' 6%. as out- of buyers. acceptances Detailed quotations follows: —-Spot Delivery-— Delivery Eligible bills of member banks... Sixty Thirty within Days. Days,, Days. 30 Days, 6!4@6H 6H@6 ...0H@0>* Eligible bills of non-member banks Ineligible bills * 6A®6% * Market stagnant; exercised a decidedly stimulating effect, and a good deal to do with the improve¬ market sentiment, although it is by financiers generally that ditions very little immediate relief from this source, * * every transaction conceded under the best even can con¬ be expected since the inauguration of an enter¬ prise of such magnitude is of itself likely to be a In the opinion of certain prominent lengthy task. bankers, the formation of the still leaves much to be arranging exchange new Foreign Financing long step in the right direction, a or accomplished in the way of American credit for satisfac¬ 6H@6 6%@6H * rates ordinarily absut 1% higher as compared with the rates eligible bills, but in present circumstances can Law Corporation, though Ninety on business of $1,000,000,000 had a ment in active, at previous/levels for eligible member and a pro¬ powers actually been organized to operate under the Edge iness. fairly pretty nearly the best foreign trade corporation with undoubtedly had Banks' and bankers' acceptances have been at posed capital of $100,000,000 and potential 7%@8°7o and names not so well known at 8%. Country banks continue to furnish most of the bus■ was subject to whatever be done with it. European collateral, also the popularizing of tory the Without widespread Corporation's debentures. public support, it is pointed out, the venture cannot possibly meet with success. The view generally taken, however, is that when in full working order There have been no Reserve bank rates. of rates now changes this week in Federal The following is the schedule in effect for the various classes of paper at the different Reserve banks: it is almost certain to stimulate foreign do away with culties in tions. a very financing and carrying The business and large proportion of existing diffi¬ movement to on revive exchange opera¬ the War Finance Corporation is not taken very seriously in banking circules, and is indeed opposed by many bankers ground that banks organized under the Edge and facilities for the on [Vol. 111. CHRONICLE THE 2362 considerable and quantities of changed exchange hands, particularly during the latter part of the week. Currency values for a time continued to show irregu¬ larity and actual price levels shared only to a minor of export demands, and that it will be extent in the gains noted in sterling until Thursday, Law have all the necessary power taking care best for all concerned for the Government to maintain when substantial advances were recorded. French policy. In any event, it is under¬ francs, after receding more than 4 points in the initial stood that whatever Congressional action is taken it transactions, rallied to 6.11% for checks, or nearly need in no way interfere with the establishment of 25 points above last week's close. Exchange on Rome, Edge Law corporations, since proposals for Govern¬ which ran off 5% centimes to 3.42 at one time, turned Antwerp ment aid are purely for relief of a temporary nature strong and moved up to 3.58 for sight bills. its "hands-off" and, would be applied only to a situation of immediate francs moved in sympathy with French exchange, ad¬ vancing to 6.45, against 6.20 a week earlier. urgency. Quota¬ committee tions in French, Belgian and Italian currencies, acting for the Governors of the New York Stock noted in our Exchange to consider the advisability of open trading per in the dollar, as Announcement of the appointment in a the floor of the Exchange only casual attention. Bankers are foreign exchange came of for on likely, however; to watch closely the proceedings of the second Brussels Conference, which opened on Wednesday for the of discussing German purpose as last week's issue, are now given in cents unit, instead of the number of lire or francs to German marks opened firm, formerly. reacted several points, then rallied towards the close, touching 1.41%, advance of about 10 points for an Austrian kronen, however, ruled heavy the week. throughout, touching low as 00.20%, as a drop of On Friday, reparation and other important financial matters. after pronounced firmness early in the day, there was Referring to quotations in greater detail, sterling exchange on Saturday of last week was easier and a recession, and losses of several points were sus¬ demand declined fractionally to 3 44%@3 45, cable tained, though the undertone at the close was heavy. An influence of the week with regard to Reichstransfers to 3 45%@ 3 45% and sixty days to 9 3 38@3 39%; trading was trifle lower, ranged bills 3 which rates, within narrow limits, with demand 44%@3 45, cable transfers at 3 45%@ 3 at Monday's market were again a quiet. was and affair dull a 45% and sixty days Good 3 37%@3 38%. at buying characterized Tuesday's dealings, as a result which of 3 day On Wednes¬ 37%@3 39% for sixty days. 2%c. up developed, strength increased moved 3 3 44%@ to 46% for demand, 3 45%@3 47% for cable trans¬ fers and 3 3 sharply, rallied quotations 47%@3 49% cable for that so 3 46%@3 48% to for transfers rates demand, 3 39%@ and 41% for sixty days; liberal buying for Christmas remittances and bursements by the banks the for were mainly responsible The undertone improvement. was strong Thursday and good buying coupled with light on offerings induced to 3 also further advance in demand bills sixty days 3 40% @3 44%; covering of shorts figured in the rise. firm and still for a 48@3 51%; in cable transfers to 3 48%@3 52, and in 3 preparations for the year-end dis¬ On Friday the market ruled higher with the range 3 50% @3 53% demand, 3 51%@3 54% for cable transfers and 43%@3 46% for sixty days. were 3 3 52 for Closing quotations 44% for sixty days, 3 51% for demand and finished cable at 3 transfers. 50%, sixty Commercial days at sight 3 42%, bills ninety points from last Friday's closing price. marks was intended ment of ment ceived the $1,500,000 San at National Australian gold has Francisco City Bank of understood to be part of previously arranged for. of amount this a been week for account New York. This re¬ notes and securities this is done, $4,250,000 is expected on another at on the Kroonland. It is also learned between Germany and other foreign governments for the purpose of changing the present clearing arrangement whereby Germany is compelled to pay her monthly debt negotiations made and London, consigned to the Bank of England, from was Continental exchanges also shown both in point of improvement activity and strength, progress enormous payments lately, Germany is petitioning Great Britain France for a different method of settlement; Greek exchange was in somewhat better demand and rallied more than 40 points, to 7.25 for checks. however are still Affairs in Greece extremely unsettled and the im¬ provement is regarded as only a natural result recent sensational declines. Government is ances of the Reports that the Greek contemplating withdrawing its bal¬ in this country It is could not be confirmed. believed that this action would have much in¬ in solving Reliable estimates present financial difficulties. place these balances at approxi¬ mately $10,000,000 in New York and around $20,balances as a whole. In withdrawing here, it is expected that Greece will purchase sterling in this market and convert it into drachmas in London. under way for a Negotiations are said to be loan in this market to the Greek Government. The official London check rate 58.05, which New York compares sight bills 6.04% cents fers at the in but thus far without results. at the^Bank of Esthonia. In are Because of the balances in cash. It is reported that shipment of $500,000 gold has been received re¬ large amount of German property in Rumania returned. that its perator shortly and $1,800,000 on the Olympic; also $1,650,000 diplomatic relations will likely be sumed and in consequence a is the S. S. Im- the It is understood that if war. 000,000 in the country Gold from London to the for deposited in Germany by Ruma¬ nian banks before the of consignment of $5,000,000 notes currency from 200,000,000 gold francs and 200,000,000 Rumanian fluence Cotton A ship¬ all in Minister at Bucharest that it is ready to return at 3 42 and seven-day grain bills at 3 49%. calling Berlin states that Germany has notified Rumania through the Swiss not grain for payment closed at 3 50%. which have recently that the German Govern¬ dispatch A stamping. days at 3 40, documents for payment (sixty days) and the official denial of reports been in circulation per on on Paris closed at with 58.20 last week. In the French centre finished franc, against 5.86%;cable trans¬ 6.05%, against 5.87%; commercial sight at 6.01%, against 5.83%; and commercial sixty days at 5.95%, against 5.77% last week.- Antwerp francs Dec. 181920.] CHRONICLE THE 3363 closed at 6.39 for checks and 6.40 for cable transfers gained $5,202,000 net in cash as a as rency movements for the week ending Dec. 17. Their compared with 6.20 and 6.21 quotations for Berlin marks 1.3334 and 1.3434 week Closing ago. 000, while the shipments have reached $3,192,000, Last week the close was as Austrian kronen finished the week • the following table: per 00.2034 for checks and 00.2134 for cable remittan¬ against 00.29J4 and 00.3034 a week ago. Italian i: Week ending December 17. Into with change finished Czecho-Slovakia on againat 1.14J4; on Ex¬ 3.5034 and 3.5134 the week previous. Poland at against 2.25 to the 7.35 and 7.45 were Last week the close foi* cable transfers 7.10 and 7.15. was considerably was extensive, some the still were The trend while doing in neutra currency, upward, and while changes were not gains Guilders led in noted. were advancing several points, upward movement, Copenhagen and Stockholm remittances ruled Spanish pesetas finished at strong and higher. on effect was Dec. of taken by the Fed¬ over 6, it is no longer possible Government Bank of New York serve $6,202,000 was operations on The Federal Re¬ creditor at the Clear¬ ing House each day in amount follows: Monday, as $91,157,321; Tuesday, $53,264,862; Wednesday, $68,973,753; Thursday, $114,069,240; Friday, $155,294,- but in the main comparatively light in volume. exchange, especially Danish transactions more the to Banks. $3,192,000 Gain Clearing House institutions. 529. There has been Sub-Treasury show Gain or Loss Banks. $8,394,000 eral Reserve Bank 1.34 17J4> against 17, and on Finland at 2.30, a week earlier. Final quotations for Greek checks As the ■ 1.17 at against Bucharest at 1.13, on Banks' interior movement Out oj Banks. ces, exchange closed at 3.46 cents per lira for bankers sight bills and 3.47 for cable transfers, in comparison result of the cur¬ receipts from the interior have aggregated $8,394,- 1.3134 f°r checks anc were 1.3834 f°r cable transfers. at a a These heavy credits reflect the huge mass of checks which from all to the New York Reserve come the Federal Reserve These as System's collection scheme. par large credit balances, however, show nothing to the results of the Reserve Bank's with the sent Clearing House institutions. only side of the account, one the Reserve Bank itself upon Bank, parts of the country, in the operation of slight net advance, but Swiss francs ruled fractionally to the bank under last week's levels. are as operations They repre¬ checks drawn presented directly House. in the Swedish Owing to conditions ruling markets, it is reported the money Financial Council of Sweden has recently instructed all the announces amount of Spanish ^Treasury issue of large a bills, estimated at about December transfers cable 30.45; at at 31.40, 30.39, and commercial sixty days at 30.85, against Swiss francs finished at 15.14 for which sight bills and 15.15 for cable transfers, Copenhagen checks closed at 15.10 and cable transfers at 15.15, against 14.60 and Checks 14.70. 19.20 and against while checks 19.30, on Norway closed at 14.82 and cable transfers at 14.92, against 14.55 and 14.65, on Friday of a week ago. Spanish pesetas closed at 13.10 for checks and 13.12 for cable Last transfers. week the close was at 12.83 and 12.85. As to France £ £ 126,811,522 ... 126,811,522 142,027,112 a.. Germany Netherl'ds 64,578,250 10,944,000 98,201,000 32,192,000 53,012,000 10,660,000 Switz'land 21,655,000 Italy Denmark another setback declined this and the week to check rate 34.25 and on cable Argentina transfers 34.3734> with the close at 34.3734 and 34.50, against 35.5734 and 35.50 last week. For Brazil the rate has fallen to 14.50 for checks and 14.62J4 lor cable transfers, in comparison with 15.87J4 and 16.00 the week before. Chilian exchange was firmer, advanc¬ ing to 14.08, against 14.04, while Peru is now quoted at 4.22 as compared with 4.16 last week. Far Eastern 56@56J4> _ __ Total week 586,521,884 Prev. week 585,525,693 a Gold exchange is against as follows: Hong Kong, 54@54}^; Shanghai, against 70H@70%; 74@74J4, Yokohama, 50%@50%, (un¬ 45J4@46, against 45J4@46; changed); Manila, Singapore, 40J4@41, (unchanged); Bombay, 26@ 2634* (unchanged); and Calcutta, 2634@26J4Clearing House banks, in their operations with interior banking institutions, have 15,682,000 "145*666 12,789,000 8,115,000 £ 91,498,847 96,851,000 32,200,000 52,680,000 10",880*666 154,865,875 1,052,550 55,533,200 2,374,000 13,575,000 25,090.000 121,941,000 3,006,000 35,206.000 627,000 53,307,000 11,707,000 22,652,000 10,656,000 1,051,000 20.225,000 2,427,000 16,664,000 11,787,000 8,147,000 "190,000 47,299,500 633,821,384 550,376,372 47,282,050 632,807,743 549.920,201 16,664,000 11,977,000 8,147,000 46,697,550 597,073,922 46,980,100 596,900,301 holdings of the Bank of France this year are exclusive of £77,934,682 ":M held abroad. FEDERAL V"v: AS AUTHORITY STATE AND TO RAILROADS. . On Dec. 11 an railroads from injunction restraining a number of increasing their intra-State passen¬ rates as ordered by the Inter-State Commerce ger Commission was continued in effect by Judge Has- brouck of the State the Court of Supreme Court, and on the 13th Appeals upheld the Public Service Com¬ by deciding that the New York Central must return to the two-cent rate within the vided in the State, as pro¬ original charter; this' obligation, ac¬ cording to the Court, was suspended for a time, and has been drews: "The automatically restored. ' ■■ Said Judge An¬ V/' obligation of the defendant to carry passen¬ for two cents a mile has not been destroyed; it was temporarily superseded. It was always sub¬ ject to this possibility under the war power, if it >ecame necessary. But when the suspension comes, it revives with all its original force. The suspension gers does cease, in the language of the statute, when the changed by State authority. The ■;hree-cent rate is authority over intra-State ice Commission." The road exists and ier, rates is the Public Serv¬ operates under a State char¬ which contains and makes a contract as to rates; moreover, The New York 23,399,000 121,600,000 3,018,000 35,210,000 1,694,000 54,706,000 1,115,000 11,775,000 4,681,000 26,336,000 Total. 91,498,847 10",560,000 152,587,112 143,985,875 318,500 54,896,750 54,480,650 2,369,000 3,313,000 11,201,000 15,682,000 12,644,000 8,115,000 _ mission American exchange there has been South 1919. £ on Sweden finished at 19.84 and cable remittances at 19.94, 18 15.48 last week. with 15.47 and compares December 1920. £ England Norway bankers' Clearing Silver. Spain against 30.55; commercial sight bills at 31.20, against 30.02 last week. the Gold. Sweden against 31.34, closed Amsterdam on 16 Silver. Nat. Bel. bills sight 1 through Total. Gold. Aus-Hun._ 400,000,000 pesetas, the bills to bear 5% interest. Bankers' go or A recent approaching never following table indicates the amount of bullion principal European banks: in the goods that are not of dispatch from Mad¬ importations of necessitous character. rid discount drafts banks to refuse to Swedish finance The and the law of 1907 which established ic Service Commission gave trol of rates the Pub¬ that body absolute con¬ and substantially all else. It there- fore and at appears once good morals to say law, good sense, that when the major power good has taken off its inter¬ of the central Government automatically re¬ fering hand the charter powers A close analogy sume. The "law" of world. [Vol. 111. CHRONICLE THE 3364 is supplied by the natural gravity is paramount and con¬ stantly operative, but such major force as resides in even a weak human arm can overcome and tempo¬ It may or may not be the best and it is not the best. ultimate; there are internal stresses already vis¬ the ible, and more conceivable; time alone can decide, and the wisest among us can seemingly accomplished has which hardly consider our anything more than a promising experiment form as wonderful re¬ If we turn back to 1787, lofty note struck by the Founders in the sults yet is still on trial. even the rarily suspend it; yet it is not repealed, and auto¬ single sentence which introduces their marvelously dis¬ far-seeing charter does not clearly show that they aimed to do more than construct a sound and en¬ matically resumes regular working when the turbing interference is withdrawn. As a legal propo¬ impreg¬ of the not very abun¬ sition, Judge Andrews's conclusion seems nable, and it appears to be one dant instances in which an appellate tribunal gives strictly according! to the law without per¬ decision the And yet, strictly goodlaw though this be, it is not the entire case pre¬ mitting itself to be influenced by considering probable consequences to follow. sented This encounter between the State and the central must of course pass on to the final tribunal. There is a like case, still unsettled, concerning the New York anti-landlord statutes, for the Appellate power Division of the Supreme lice Said Judge Jenks, "whatever the con¬ powers." tract give Court has added another sustaining the legislature in using its "po¬ decision rights of the relator or its tenant, they must way Understanding it thus, what then—what shall be while the experiment done The whole is pak to the public welfare ... a statute enact¬ police power (the law of ed in the exercise of the overruling necessity, as it was once termed) is para¬ mount, and cannot be affected by previous contracts Yet this State has between individuals." is less than the whole—the axioms of mathe¬ us that. If a difference arises, which matics tell indisput¬ for tuting the whole) must govern the parts; no seces¬ sion by rebellion or part any To day, in the Federal Circuit Court, where Judge remarked that a constitution is not a code or a stat¬ actual "case" presented, the to nearer come United States, which shall be made in pursuance thereof, and all treaties made or which shall be made every Hough (with Judges Mayer and Hand concurring) the result is paragraph 2 of Article VI of the Federal Charter declares that "this Constitution, and the laws of the ter in still another sustaining decision, on Thurs¬ persistent, self-dictated course happen in our human imperfection) tracts," which is one of the things the Federal char¬ upon or be permitted, and if the central au¬ liable to be ruin of the entire structure. the This was touched can thority allows such a course (as, indeed, does often under the "no State shall" do. number of the Our own bodies offer us a helpful analogy, there the whole (the intelligence and will consti¬ parts? ably passed a "law impairing the obligation of con¬ says is working itself out? equal to the sum of the parts, and a shall control—the whole or any or a involved. and during modus vivendi for a new nation on a new continent. authority of the United States, shall be law of the land, and the judges in supreme State shall he hound thereby, anything in the constitution or laws of State to the contrary not- any It would be well to examine this withstanding." carefully, phrase by phrase, that we may note its force. It was agreed to by this State, in convention ute, "and is not to be interpreted with the strictness with the of Apparently, this action constituted and completed a a private contract; to this doctrine we owe the rulings that even the contract clause of the Consti¬ tution does not override the power establish the regulations reasonably health, comfort, or of the State to necessary to secure general welfare of the com¬ Long ago, Seward declared the conflict between The contract. objector may cite the tenth amend¬ ment, that "the powers not delegated to the United States the by the Constitution, nor reserved by it to States, to the or munity." others, and was ratified on July 26 1788. and are reserved to the States respectively, He is entitled to the rejoinder, people." perhaps declaration and rejoinder are about slavery and freedom "irrepressible"; it proved so, equal in reasonable weight, inasmuch as no arguing for it continued until a final issue settled the ques¬ in the tion of dominance between a and declared that because Lincoln the two. house divided a self cannot stand he did not which to) be a matter of good morals rather removed rangements, and he and was above or usual willing to To territory. attacked was seemed from against it¬ expect that this country could continue half-slave and half-free Lincoln, the Union saw save in 1861 something human ar¬ it without mere final court of strict settlement. logic is likely to produce That must As the "Chronicle" nature of has already pointed out, the subject must largely determine its treat¬ a ment, and transportation is in its nature a continu¬ ing process between widely-separated points, that being according to the area and peopling of the country. Our intra-State carrying, of either or both determining the fate of the institution of slavery; merchandise and passengers, it ial ; was not until later, when he recognized the mili¬ in any tary necessity, that he brought himself to proclaim the latter must the we can manage nation, to to enable persons ture is a a piece of military policy. Yet if to partly remove ourselves, in imagi¬ point in space and time distant enough dispassionate judgment, most thoughtful will probably tnerely an agree that our political struc¬ instrument of exped iency; there must be some form of external Government men become able and ready to govern according to the laws of God) and the form have is the (until themselves we now latest, and it is open to argument whether ics preponderate and control, so far as nature of the seems case incontrovertible and about politics is concerned. It therefore that, on grounds of econom¬ (and in this matter the two seem convertible govern. is comparatively triv¬ difference between intra- and inter-State, emancipation as a be reached other¬ wise. terms) inter-State traffic must In this present issue, the higher rates are in collision with certain lower rates State laws and contracts, by and under and it is undeniable, as a legal proposition, that the roads are "State" cor¬ porations and owe at least a degree of submission to the State which created them. Dec. 18 1920.] Now there are only two grounds CHRONICLE which the upon and action of the Inter-State Commerce Com¬ power mission in and THE apparently it is not increases ordering certain rate called in question. are, pleasant to pay can be, One is that for transporta¬ more money tion service. Not much argument seems this, for the same indisposition to needed upon pay more than one must was working, and working disastrously for everybody, all through the long course of "regulat¬ ing" which weakened the roads and brought them towards the final seizure. pay more on do so, freight, People do not "want" to anything, but consent to or on because of the of the thing and the reason good results expected, in many situations of daily living; have consented, in the we taking back and restoring railway properties. wise and So is it not, therefore, both short-sighted, not to say issue raised lower It is present rates? behalf of the on necessity for a ture growth that tion instruments, and it would surely be and restore we save un¬ our fu¬ transporta¬ our bad policy a antagonize the Inter-State Commerce Commission that it has abandoned its old attitude of hos¬ now tility to them. The V - of other the two it a Stand upon a duplication of that law and commission is posed. suppress unfair methods in the role au¬ this broadly, and enforce cate, overlap and conflict with the Trade Commis¬ sion, naturally leading to disputes of jurisdiction. If anything useful can be accomplished by an at¬ tempted statutory pursuit of alleged unfairness in trade, the Trade Commission has already accom¬ plished it, if better directed, or, good has no come from setting doing the same vented that which tended (and probably needed) State and intra-State than a material tions at once, here pen an they object irresistible force an body, it dissension. may comes be better left If Leave unsettled the and waive can its nitely abandoning it. safely, dently. against as a have im¬ an puzzle and problem of can own In the middle will walk you very pru¬ We have the gravest of financial, industrial defer them deal with we cannot all, for they refuse to be put by. the waiver when most imperative, and in a possible, not crossing bridges Let us spirit of until we to them. proposing nothing less and better than Governmental ownership TEE PACKING BUSINESS— NEW MONSTROSITY PROPOSED. The coal mines of the supervision and country regulation are would cused of epithets number of a This later attack same tend the meat business on It happens that great market is back to sold at tors quoted are now coal, taking as harsh ness."^;-/,;. yy; The unfair left In Senate Bill The the "Federal Livestock Commis¬ .v' objections •, are so many /■ , and serious that it is not easy to choose the order of citing them. bill is of greater length and detail than the Federal Trade Commission law of six years ago, and may The an ob¬ go on, as I, be, shall advocate case, my op¬ ■ . v'.'; V:., 5 practices forbidden to the packers them, a be or sure how time; nobody they soon cohtrol whose orders cannot be known for are the even can may be Every packer is placed in advance under changed. overseers beforehand, themselves will not know what they will command or how often they will shift. packers are forbidden to engage in the effect of The so. any manner foodstuffs except livestock products, when any so engaging operators fair in any may be to lessen competi¬ are overseers say forbidden not only to be respect but to "charge rate in commerce." any un¬ unreasonable Observe that this goes step beyond the Trade Commission Law and con¬ or to regulate prices, since if the prohibition have Livestock Commission," the meas¬ But Two Sena¬ declaring for intervention of the Commission from time to foresee ing business and the country are threatened with sion Act." fury. wholly undefined, and hence subject to opinion 3944, brought forward from last February, the pack¬ a figures, hogs having position to Government intrusion into private busi¬ decide what as which has been that pork in that the coal mines," and the other saying he over is to be enforced the to be cited us willing "to modify somewhat, in this what would be bill "to create news pre-war the remedy as fers power ure extortion and saying that "if the matter is to one for one, is from Chicago dispatch of this does not count with the blind to comes $9, against $10 30 in August of 1916. possibly bad yet naturally improving conditions to a prove a only last Tuesday, repeating a worse. success coming for several weeks, told price utterly unendurable movement to go from ac¬ of which, if any one shut-eyed and unreasoning fury which will monopoly. is unspeakably "the Big Five," and as crimes, proved, would have justified the severest penalties. straight towards "nationalization," and with what an the remedy for alleged tion, etc., in other words, whenever the threatened with which as evils, and its violent abuse of the packers, whom it in A The Trade Commission has itself remember its The REGULATING capable particularly and persistently upon packing industry, and "Chronicle" readers will the without defi¬ proverb in Latin, and says a sover¬ concede present claim governing problems to deal with, and come we to be agreement and not eignty in the States, for that and agree—any in two direc¬ better return to the position already taken: may most to agree can move without breaking in two. that the open way seems cases Inter- example of the old puzzle of what will hap- when movable we to prevent. in¬ authority cannot operate si¬ multaneously—unless more was or not be regarded, however, as may piece of work. have it that size and than worse not needed to do are work. same Perhaps this the accomplish it; may body only evil could one another, and certainly two up pieces of machinery of from come barrier to far or present proposal would dupli¬ literally, and it would raise at State boundaries commerce com¬ approval, either by its actions The successes. competition has acted fussy busybody and has not the the "commerce" clause of the Constitution a of the mended itself to its pro¬ That ostensible undertaking to uncover and belabored with " grounds is that State thority must be paramount and must control, with¬ in the State. jection which ought to be sufficient of itself is that inconsistent, also, to take sides with any to matter of very ravished and depleted our 3365 one one more are must be allowed to "unreasonable." So here we price-regulating scheme in respect to great line of necessaries. Possibly It is On prices overseers worse is the proposed licensing scheme. "voluntary," if one wishes to perpetrate a jest. application, the overseers "may" issue to any¬ body ness a certificate of registration for doing the busi¬ conducting or operating stockyards or "of slaughtering livestock, or processing, preserving, or THE 2366 perishable foodstuffs/" with provisos set forth at length and in much detail. The applicant must satisfy the overseers (inter alia) storing livestock products or to the location and as other points of the grounds and facilities he proposes, including his own finan¬ he must abide by the provisions of this section and the rules, regulations, credit, standing, and resources, and cial in advance "to comply with and agree and orders made hereunder." to do and submit to vance He must agree in ad¬ whatever may be handed time, and one thing required out to him from time to by this Section 25 is that he must "furnish the serv¬ ices and facilities of his business on fair and reason¬ able persons This unjust discrimination to and without terms applying for such services and facilities." (or may be read to mean) that he must means allow his facilities, on indirectly interested in the business of any packer "reasonable" terms to be passed upon This section, calling itself one for "voluntary registration," means that who¬ ever "voluntarily" comes under it will be bound from crown to heel, and whoever declines this voluntary by the official overseers. surrender—what sort of time will he be It is rule in selection for office, nobody the too common who knows anything of the subject is eligible, but is to be turned over to outsiders. that the business Are to move further towards the nth ready we of Governmental interference, when all pri¬ power vate business shall be left nominally with its owners capital (if pliant and optimistic who furnish the enough) but shall be controlled by non-interested and non-competent overseers from the outside, poli¬ appointed by other politicians? ticians nightmare? No—propositions such as this are an anachronism and intolerable; they would turn back the hands of which are beginning slowly to the clock of progress To be condemned and silenced, the again. move proposals need only to be noticed enough to be un¬ derstood. REDUCING THE UNITED STATES PUBLIC dinarily advanced attempt to lay the hand of Gov¬ are Whoever will dis¬ and think calmly can see miss hatreds Will pros¬ perity and low costs of living come out of any such DEBT. How is the Government ever objections to this extraor¬ private business. vocation, or employ¬ Translated, this means that, according to ment." hardly necessary to take space for a more ernment upon that meat especially perishable, and are therefore capable of being so handled as to permit with¬ least be a commissioner, but he shall not may likely to getting on with the offended overseers? extended statement of the foods operator" or "engage in any other business, competitors to share his plant and other have in [Vol. 111. CHRONICLE holding and other methods of extortion; that they indebtedness of billions If the task? pay off the during the substantial start been made on the Has any war? going to accumulated Treasury Department is constantly borrowing money by selling certificates of indebted¬ how ness, there be any present reduction in can the Government debt? require combinations .of capital, a very great scale Light is thrown on these questions by the detailed operation, and the employment of every device figures given in the annual report of the Secretary of for utilizing by-products and cutting out wastes, the single matter of refrigeration and refrigerator cars being one (but only one) example. In the whole list nothing which, by its of consumable articles there is nature, is so difficult to bring under any prac¬ own tices of vicious monopoly and so lends itself to (in¬ of the Treasury, which has just been published. the first of Government issues old called the the of the and loans In place, it should be remembered that the bonds, the four Liberty Victory notes, "funded," or more or Government, now constitute what is less permanent debt amounting to about 20 In addition there is the "floating deed, virtually forces) the rule of very large trans¬ billion dollars. actions at Moreover, add¬ debt," represented by Treasury certificates of in¬ ing certain other products and commodities further debtedness, which in August last amounted to nearly a very utilizes the small profit ratio. packing machinery and its methods of three billion inducing the lowest costs and the least wastes, and duced to thereby tends to the lowest prices on all lines of reduced One of the worst foods. yet most persistent notions in the whole anti-trust crusade is that nation of capital and effort upon one a large combi¬ line of indus¬ tificates to the exact more ing necessarily in features of of what is If a contrary, and there is noth¬ common between the obnoxious trust and the existence and indiscriminately cursed as workings "big business." bigness ip badness, why not indict the sun? we may recall that, a year ago, to placate the Here It appears ous of funded has of Secretary of the Treasury, until the expiration one entry of ing. to divest themselves of The decree also interests in all so-called "unrelated required them to sell their stockyard railroads and terminals and in market newspapers; the retail meat to dissociate themselves from year after the termination of the war, to buy annually up to 5% of the amount outstand¬ Under this authorization, the Treasury has bought and canceled bonds to the amount of $1,764,896,150. These purchases included about billion each of the and about business, to abandon their branch Then it one-half Second, Third and Fourth Loans, one-quarter billion of the Victory notes. seems that Congress provided that repay¬ houses, and take sundry steps in diminution and ments withdrawal. made to them should be It should be further said that if the meat business The Second Liberty Act, with subsequent amendments, authorize to lines." nibbling at the great mountain debt, and that quite an appreciable effect already been produced. Bond the from the Secretary's report that vari¬ mice have been bonds decree requiring them, within two years, These Treasury cer¬ practically represent borrowings against stantly resorted to by municipalities. hostility to them (if possible) the packers consented a by about $200,000,000. anticipated tax payments—a practice which is con¬ try aims and tends to increase prices; it aims and tends dollars, but which has since been re¬ $2,475,000,000, and shortly will be further by foreign Governments on account of loans retirement of applied to the purchase and Liberty bonds, and that there has be and is brought under overseers, there is no fixed line of stopping; everything (including agri¬ been culture and the by the Government from the Federal Reserve banks may terms of No. press) might be dragged in. By the 3914, anybody who is not "directly or $119,109,050 Reserve Act as so paid and applied. The Federal provides that the net earnings derived franchise tax shall be used either to supplement Dec. 181920.1 f the gold THE J ■ CHRONICLE held against outstanding United applied to the reduction of the out¬ standing bonded indebtedness. The Government States reserve notes, received 3367 ered faces or softly. Perhaps, over the river glide iceships, ghostly in the gathering dark, Perhaps, clad the ground is white with its mantle of that account for the year 1919 an amount sufficient to purchase from the South. erty loan bonds. mas on $2,922,450 of the second Lib¬ This amount will be many multiplied for the or year 1920. as "for patriotic the Secretary puts it, present bonds to the Government. These gifts have not been numerous or large, but they have been sufficient to $12,850 bonds. Occasional bonds are put up retire as security and forfeited. $3,550. These have amounted to section of the Second a Liberty Bond Act, 4%% Liberty bonds and 4%% Victory notes are receivable by the Government at par in payment of estate or inheritance taxes. Some thrifty executors have taken fords advantage of the discount which this af¬ the on amount of tax, and have paid in bonds to the $9,781,750. a Victory Loan Act permanently appropriates sinking fund, effective from July 1 1920, of 2y2% aggregate amount of bonds and notes standing out¬ July 1 1920, less the amount of obliga¬ tions of foreign Governments held by the United States on that date. In 4y2 months this appro¬ priation has redeemed bonds to the amount of $15,- 040,250. the on The aggregate of these items, representing total retirement Nov. 15 and that a cancellation of bonds 1920, is $1,911,766,050. of the amount of bonds now to This is nearly 10% oustanding, and shows substantial start has been made in get¬ ting rid of the war indebtedness. very Eve! ' Care is absolved. The chimes in the of good-will. does not What, now, are all the the or Whether full, there is always, at this waning of the year, a gestion, of haste, of anxiety. Usually stock is to be taken. fort Books to be are to be balanced. are feeling of con¬ Fag ends of ef¬ smoothed out and finished. And in the mind constantly, though as yet covertly, are re¬ volving the plans for the coming year. Nervous ten¬ sion increases. perative tone. for Office orders often take well won. of energy ranted it '.T-. . toiling efforts of the huge struggle called competition—for once forget—and, forgetting self, live in others. can of holly waits, to where the yule log glows, even though it be in the imagination, to where some little token awaits of that divine that makes us all of kin. standpoint, it once. As along, there own the The very poor are not forgotten. appears. rich find a there day called into the soul comes a how, trying to day that precedes ful face to the quiet stars, wears lehem. And exclaim, "I comes but a glad it is nearly over—glad year!" a Counters winter's day. are Desks close with left in piled confusion. a From mounting serried tiers of windows in tall tem¬ ples of trade, lights flash out. denly, there is clamor and call. snow a in the air, In the streets, sud¬ Perhaps, there is eddying lightly, touching the fev¬ evergreen home to stony dering expression. the goes Down in the happy thought has erected the "Tree of Light"—an transplanted from mountain city, to glow and gleam in tender won¬ and shed its bounty into little hands. eyes Up and down the crowded streets there horns and confetti. are blowing jangling bells, and the colored showers of But know, oh cynic, if one there can be at this time of the year, don only conceals a that this hilarity and aban¬ sentiment that was not there of yesterday—that has its far love ers that much seem or that little which not fond. stir in not in One whose source surpassed all other love—the sharing with oth¬ from honest comes work in the fields of life where all are free, though Strange |would it be, did there countless reflective minds, from this the thought that life prosaic, life economic, source and stimulus in those Perhaps, in the more serene we love. quiet of the Christmas Day, when families reunite under the parental roof, gather in gentle converse around the when friends generous table of the feast, thoughts of the meaning is seen were pressure for the madness others not deeper hold though the words are not The Gift, emblem of unselfish generosity, to be "nothing without the Giver." This constant the then—oh, the miracle of it all—there falls twilight of bang. once am the 1 then, perchance, out into the street Life must have its Beth¬ over . spoken. comes was •' of life take buyer, from those responsible and those who And the heavily to the star that out¬ even shines all the others—the star that tired bodies, flagging minds and not, almost involuntarily, even in the midst of subdued the everybody Some¬ endeavor, this slavery to the material, triumphs and justified, by a spiritual exultation that lifts thank¬ has its serve compassion and charity is an unwar¬ remem¬ mysteriously know not how, this long, arduous industrial we scene, To the "retail trade," however, access of buying—albeit harried And that soothes and softens and makes whole. sometimes, expectations scarcely acknowledged, there this in¬ And the glow of sweet satisfaction in brances not born alone of riches. From old and young, from seller are sagging spirits. are seems quality of friendship For this is the blessed Out of the welling kindness heart, unknown though be the source, the Gift of the they a year, business, the triumphs and failures Homeward wend the millions, to where the wreath interruption. brings its and on ... comes It will not be denied that with the distractions of at a cause that the goal may be Into the midst of this there from the material im¬ an Employer and employee turn currents Christmas. on Lack of concentration is held reprimand. creased message heart, broken the spirit, that the gentle gladness of this hour. catch the burdens of one steeples ring their mellow Square CHRISTMASTIDE. the commercial stream flows scant Joyous lips Hard the toiler. The business year rushes to its close. yet, time of remembrance. I The of the or green, a balm steals up It matters not. For it is Christ¬ repeat the old refrain, "Merry, Merry Christmas!" of . Under purity; lingering touches of The streets fill. -Jy: From time to time various persons, other reasons," times amid accumulation, of marionettes, in treasured that holy for fortune, were of there holies, purified and sacred temple of the hidden heart. Power would be but the who gain it could not good of humanity. enginery of ruin, if those in its wise exercise the see Wars are never waged over the solemn self-abnegation of those who, striving for personal gain, succor the loved ones of home. The vast and ever-increasing complex of commerce, un¬ devotion, where those who ravels into the fine line of conscious of helping others. We our diversity, we are co-operative in help themselves are all united in are [Vol. 111. CHRONICLE THE 2368 world, and culminates lateral effect in the business specific drives upon the Congress to enact in now the world in legislation in aid of farmers, who by alliances are attempting to influence price by refusing to sell. our private endeavors. Only when man would con¬ Here, with no necessity of war behind it, is a plea quer by will rather than by work does he despoil for special and emergency legislation, which creates the vineyard given into his keeping. another emergency. Christmas Day passes. The wheels of toil and We are bound to consider this demand for relief trade turn again with ponderous roar. The personal competition, we are at peace with our task claims once more its due. But few there must for thanksgiving and cheer. And greater than all is that quiet lingering of the absolving sacrament of forgetting self in remembering others. For the toiler feels again, even with lighter heart and re¬ newed courage, the falling of that shadow that lifts so slowly—the shadow of the world at war. And the lesson grows plain, the lesson of concession and conciliation, the lesson of increased and increasing toil and effort, that there may be more for all be¬ great city who have not some cause be in the there is more for each. cause Not in planning ideal¬ conceptions of artificial rule, playing for points of power by organisms organization, lies the hope of peace and plenty, in consecration to work, that all have more of ism, not in stupendous in not and but tified POSITION OF THE FARMER. Is it jus¬ within the national life? by any emergency Having extended aid formerly, under the belief that it would stabilize conditions, though that was mistak¬ en repudiated in feeling, does the Gov¬ and was soon anything to the farmer because of its ernment owe former Let us see, as to the cure. Mani¬ legislation ? festly, confining ourselves to of marketing son of does wheat (and it not do so in The temporary effect, of no sense. price duration, could only be to advance the known consumption. somewhat for home If this is but¬ prohibitory tariff on importation, the similar, and the reaction just as disastrous, unless the as a hoarding of not advance price will not) then the fixing of price will ultimate the the present time (sea¬ wheat), if in the face of the fact large world crop and open seas, a American effect is EMERGENCY LEGISLATION—THE by a worse condition? Will it be followed tressed by a rest. Will it cure the evil? several standpoints. from price and prohibition are to be continued policy, in which case foreign trade is pro¬ fixed right way is portionally blasted—the evil remains. Artificial relief from the returning power of the merely to nullify it by doing another. It is laws of supply and demand will produce a worse proper to repeal a bad law; but not in the doing of condition than at present obtains. All the laws of it to enact another. Generally, it is conceded that, all the Congresses on the North American Continent while some of the war legislation was justified by cannot prevent England and Europe from buying necessity, part might have been avoided, other parts It is proper to undo a wrong; but the not , wheat in Australia or the Execution is becomes more important price. might have been more wisely framed. another question, yet now armistice. the with of Con¬ The present session of re¬ be said, is confronted with the admitted duty gress pealing emergency war legislation. introducing politics in a without It may controversial way, that it has been commanded to do so by the people. temporary laws affected certain classes That these citizens, is no warrant whatever that such classes of should now of that the enactment of other emergency in their in lieu ask for their continuation, or statutes Emergency legislation, while con¬ place. trary to the principle of stable and equable laws a whole this for people, has, whatever the time of enactment, fault—it grave necessarily creates another Let us particularize with farmers and the wheat It is true this legislation expired by limita¬ crop. tion, but the effect is the same as it would be under a repeal. Let put in evidence first some of the us facts in the case, eager namely, that farmers were at first for the Government fixing of price, were on the whole The legitimate price to the American farmer by the price of his surplus in for his wheat is made pleased and satisfied with two dollars and plus walls back as a depressing factor on ment can certainty in price by legislation than he a by hoarding. —time which ernment to 1919. was refused, the relation of Gov¬ price ceasing entirely with the crop of This left wheat precisely where it was before, governed by a world-market price, but under new conditions. ers, These conditions are now upon the farm¬ cannot be escaped, and have resulted in a price in local markets ranging as low as a dollar and a quarter a bushel, causing an estimated loss to farm¬ ers, by former figures on this year's entire grain off than he would have been to at the As to the start. ful effect proposal for Government This form of relief is particularly practice. special emergency legislation, creat¬ as ing another emergency, tries affected and unjust to other indus¬ by the aftermath of war. All this is unfortunate—for the farmer. look at conditions at must And it may as not to on the us, and that "all the king's king's men cannot set Humpty Yet a flood of bills are being Congress—nine-tenths of which are again!" up in allow emergency But we large and as a whole. well be said of the evils of war that they have fallen introduced doubt¬ policy, and it is scarcely feasible in as pernicious resumption in the natural way, but artifices for curing one ill though it cre¬ ate another. Immigration comes to the fore with tremendous It is said that we are in danger of being over¬ voice. whelmed ures are millions of two billions and a half dollars.' This is not easily borne, is a heavy burden, has tremendous col¬ cannot accept the inevitable loans, it is not defensible in principle, it is of at this crop, If he fails in the end he is worse idle investment. Dumpty guaranty of two dollars and fifty cents In either case only time can tell profit in waste, interest, and consumes manded a So that the farmer can no more price-fixing. predicate horses and all bushel, which the home- consumption price in spite of attempts at Govern¬ twenty cents, but later grew dissatisfied and de¬ per him, the sur¬ That being denied the world markets. actual emergency. Argentine at its seaboard by a muddy flood from everywhere. Fig¬ twenty-five adduced to show that fifteen to are seeking ways to get here. dispassionately. all come at Let us look First, twenty-five millions once, and the process must DEC. 181920.] stretch over resources and a THE period of even such as to mere honest, useful labor possible citizens of good character to start with that will tie themselves to the to Second, years. flood of a CHRONICLE our prove institutions and our soil, that will be loyal form of factor to accelerate a ment and our our Government, may internal develop¬ foreign trade, and cannot exhaust our vast and undeveloped wealth and opportunities that given thus more fully to the world would advance its civilization. There questions of adaptation, are distribution, assimilation. We do not discuss them Are we ideals of farmer's fear justified, in view of liberty, in putting interest, under professions and our the bars? up Take the have just considered. we proper called flood of Need he sifting and distribution so- a cheap labor, to meet falling world- prices for his future crops? expression, "the world is Again, there fire." on Can was an in large men bodies, whose homes and prospects have been burned be blamed for seeking up, ment that the fears of the banking interests are not valid, and that from the point of view of sound pub¬ lic policy, the Dominion Treasury has nothing to lose in the restoration of free This is borne out in world, peaceful parts of the more abundant opportunities for themselves more and their children? And still, again, is it to be trading conditions part by certain facts which have only come to light with the disbanding of the "sta¬ bilizing committee" of the Bond Dealers' Associa¬ tion. It appears that this Committee, finding itself badly overloaded with offerings of Victory bonds beyond the absorptive capacity of the Canadian mar¬ ket, entered into an arrangement with the Minister of now. 3369 Finance, by which passed eventually the Committee to the Dominion Government 100 million on dollars in unsalable Victories. ernment in turn The Dominion Gov¬ sought relief from its new perplexi¬ by apportioning $30,000,000 of the undigested ties bonds sort of as a sinking fund against the main is¬ arranging to absorb the balance gradually. sue, latter procedure, however, give may way The to a more welcome alternative, whereby in the event of higher quotations for Victories, the Minister of Fi¬ market nance feed out may of the securities. some As to the pected that other free republics and vast undevel¬ probable effect of any introduction of cheap securities into the Canadian market at the oped territories will have present time, the bond dealers assert that ex¬ appeal to European no Canadian Government emigration? Our thought is that another lation will only create more deeper in the mire. us era There is certain bank failures in one of frenzied legis¬ unrest and may drive some section. not discount them at their worth when realize that tastic we we come to particularly under the fan¬ occur protection of the Non-Partisan League? Loans to cotton also they disquiet in But must planters, because of inactive markets, are Yet cotton is peculiarly a world- contract with bondholders interest and If one Minister of ation which a will actually aid cotton rise and loan, which will only aid in holding for will do nothing toward actually moving Tax-revision is im¬ perative. forms taxes But almost extinct (extinct in the nothing. needs not go us new of conditions) will avail little device, only just and equable laws. from bad to by hurried, ill-con¬ worse probability seems every the purchase of foreign-owned .v'/" [By Henry A. The French have "It may es: DOMINION EMBARGO ON THE PUR¬ no mean write banks entirely the embargo over on proposal to remove the importation and sale of foreign-held Canadian securities. million dollars of such securities More than 350 are said to be held will the Canadian Bankers' Association and a highly inviting invest¬ to be created by the offer of The de¬ movement, the can be no as required by common peace an com¬ ambitious at¬ form to be "understanded of which he a he is to be a tre¬ well-being. "furnishing the back¬ asserts has never been To done; is men perform this task he has sought long list of individuals, some of them to recognized •The prove human this, "any binding culture of inconceivable." the aid of to urgently necessary educational reforma¬ without and "friends." endeavoring to persuade the Dominion Govern¬ a contribution an create run universal The book is author believes be securities, at attractive prices, would on savings accounts, the bond dealers a people," it will manifestly British-owned a modern Historical scholars tempt to supply such ideas ; if this can be accom¬ plished, especially in tion," argument of the banks is confined to incident in historical ideas. mon re¬ country at the present time. sure attractive theory an itself to the prosperity possible for the world without the opportunity popular reading. the conviction that there bone of a a should not history of the universe,* attempt so to deal with it is regarded gards as highly inimical to the financial welfare of apprehension that romances interesting and suggestive, and prove as an mendous grave sure expect it to add to their knowledge, but it ing of While the why reason simplicity and unity. surely the Kingdom alone, and the sudden dump¬ large volume of these would create a situa¬ tion which no of existence which lends in the United any presumably especially if he has adopted be told proportions has arisen the of H. G. Wells will be pen fresh and readable a to books and speech¬ as Starting with the idea that man's history must organized bond dealers of Canada and chartered Stimson, D.D.] saying requirement. therefore well worth Ottawa, Canada, Dec. 17 1920. between the is There a writer of novels and fanciful SECURITIES. controversy of I be true, but it must be interesting." Anything from the to meet this mand for legislation. CHASE OF FOREIGN-OWNED CANADIAN are on delay. will not THE ment market stabilizer. a EFFORT.* indirect To meet squarely a four-billion tax bill no ruse or sidered the of business HISTORY A-LA-MODE—H. G. WELLS'S a cotton into its natural market. A Finance, there embargo in growers market than the doubtful expedient of Government Let no proposed. reaching or longer of it has Canadian securities will be lifted without much fur¬ ther crop staple. Is there not more hope in the practical helpfulness of the proposed hundred-million corpor¬ a par, judge by the recent statements of the may that the any to regular payment as redemption at assuming the role the as fully intends to maintain its The as scholars, the rest mainly as book, however, in its tone, arrange- Outline of History; tvro vols.; by H. G. Wells. Macmlillan Oo. of Jesus Christ or the writing is definitely his own, and is to he ment and It is evident that its literary quality is judged. so [Vol. 111. THE CHRONICLE 2370 this is to augur field of assured, and that the book will be readable. religion He established than poorly the hope of the world as the Divine Redemption and the arena of the a find Kingdom of God. It is useless to follow the assumed line of devel¬ of opment of Christianity in an adoption of the terms chapters dealing with exceedingly comprehensive and interpretations of various heathen rites for the separate subjects and periods, as they must be to Turning to the two handsome volumes we they consist of nine books, each made up that universal existence, cover earth to a from the making of the stage not yet disclosed, when "the strug¬ gle for the unification of the world" is first The constructing of its own teaching, especially as in¬ probable. books, covering the prehistoric three and the dawn of human history, are, of course, ages debatable, but give interesting general surveys. In connection with the succeeding three books, on the preceding the Christian era, they will attract times readers is who want a comprehensive tale covering Beginnings," a realm in which new material "The constantly coming to light, and judgments have to be the new era with the story of early Christianity. Here, while recognizing the Gospels authentic history, the attempt is made to treat as Jesus Christ as a man of "lean and strenuous per¬ sonality," who has been much wronged by a mis¬ taken reverence, of his and and as to whom "our concern is theological and spiritual significance not with the life, but with its effects upon the political every-day life of man." convenient to drop the early Mr. Wells finds it narratives of the Gos¬ earlier Jewish history, and declares it "a matter of fact" that all that body of "theological assertion" which consti¬ pels and all the setting of Jesus in tutes Christianity has in the Gospels little support. This he undertakes to confirm by referring to the Sabbath, and the worship of the Virgin Mary. One wonders if he has any conception of what religion to-day is as related to Jesus Christ, or if he has read a single authorita¬ late disputes over the Trinity, the This would be helpful requires the oneness of Christianity with the world religions, and the solv¬ ing of the various world problems by It is true that he finds small hearts." "this Galilean too much But he offsets this by declar¬ bold and ready But the most frivolous reader will believe that the cross of Christ, which assumptions. find it hard to 2,000 years is still the most vital visible force after world, and the proclamation of "the blood of in the Christ" as atoning sacrifice, are derived from an Mithras," when even this is admitted "the cult of some forgotten mysteries." surprising that, taking this view of the It is not Personality with whose coming the world author should take little our swings light and the new age begins, about from darkness to cognizance of the forces affecting human history. The religious and spiritual conceptions beginning with other than material S1}. Paul, interpreted especially by St. Augustine and John Calvin, he does not recognize. He gives small space to Paul, almost none to St. Augustine, and does not mention that diverse and recent as much of Calvin, though historians as as and Froude declare Renan derived, and continued, they still shape so Art and literature also have thinking. our place in this scheme of history; the great names no lines in those do not appear. It is curious that though hq does not mention Shakespeare, Milton or Dante, Goethe or Schiller, Kant or Lessing, he gives to Karl Marx, who he says is "being justified pages by events." When Mr. Wells takes up ments of theology. our an ecclesiastical history or of Christian tive volume of for to to be "centred upon frequently revised. Book VI opens by the Apostle Paul. outline of history that fluenced the great national move¬ history, like the story of the Greeks, the rise and fall of Rome, of Islam, the great Mongol Empire, and later, the age of the Great Powers, he is at home. more Here he has themes for which he prevent a primitive is better fitted, or where his limitations are not so being also a Nazarine, and nothing to His vivid imagination and an easy prevent a personal disciple of Jesus from accepting conspicuous. and simple style make the tale attractive, though it all the recorded teachings of Buddha." And this, has a certain pretentiousness and air of final au¬ forsooth, serves to establish the place of Jesus, and thority, which is, perhaps, inevitable where a clearof Christianity as simply another world-religion in cut theme is to be maintained, but which will be the line of the many that men have devised to satisfy troublesome to readers of history who value more their needs, and as an incident in the development ing that there was "nothing to Buddhist from of the universal movement and the bring peace the Its outline of the identity of Christianity with them important historical aspect of these most This may be true if one ignores of the life great religions." both the claims and the main features and character of Jesus, and if one strips Chris¬ tianity both of its essential doctrines and its relation with Him as the Son of God. hardly to write history, even in this is The confusion of vital But to do "outline." thought appears when our author quotes Dean Inge: "St. Paul understood what most Christians never realize, that the Gospel of Christ is not a religion, but religion itself in its most uni¬ versal and deepest significance"; and then says, "It variant we must look; it is their accumulations and excrescences, their of language and phrase that cause the is not to any new defects, their differences rivalry," between the religions of men and tianity. careful statement. to the world! "This essential is ideas that are to To see no further into Chris¬ the life and claims nineteenth century, the power to in great material changes of the in the railway, the steamship, handle metals in the mass, the advance chemistry, and in medicine, leading to the fertili¬ zation of the soil and the and all the varied a setting as and form The tional of we are a one now are put in such available in the progress of hu¬ a fresh phase of history, stirring picture. closing chapters deal with "The Interna¬ Of these it must be said that as yet all too much under the influence of the war as it has been furnished story by the daily pa¬ to be prepared to accept any "true account" it; and good electricity, Catastrophe of 1914," and "The Next Stage of the of preservation of human life, they constitute History." pers, of to lead to a clear understanding of the as physical forces manity, uses as as any to. the future one guess is perhaps as other^ It is still an open field for any¬ who will "set up for a prophet," even though Dec. 181920.] THE CHRONICLE such a one may perchance escape the "gratuitous obloquy" which, according to George Eliot, awaits was the With who man attempts it. Mr. Wells is better prepared to face the risk than because he has the comfortable certainty being widely read and, if one may believe current report, is already well rewarded. actually smaller than in 1916-17, when net ar¬ were 216,498, and makes a poor comparison rivals the The immigration and emigration statistics of the United States for the fiscal year unavailable, the 1919-20, heretofore announced in the annual report of are Commissioner-General of week, and they quite naturally heavier influx of the recent year, times. The close of the a ward, and that is have to as served indicate much a foreign born than in any very although decidedly less than in pre-war expected to mark abroad this Immigration in November 1918 was war turn in the flow of aliens hither- now a proven fact, but restrictions departures, and here to to entrants, as keep down the arrivals to a total very readily assimilated. ever, it is to be noted that of ordinary labor the in¬ At the time, how¬ same ward flow' has been under rather than over the pro¬ portion desired and that the number coming in to go into domestic service has been woefully below level calculated measurably to relieve of the one a ur¬ The usual not are much the be can der from from Mexico and the northern over the Dominion of the southern bor¬ Canada, and, boundary these as largely agriculturalists, the needs for help in the Southwest mitigated. and Northwest on farms somewhat were iest in several years, already noted, the heav¬ but against this there was an emigration of comparatively large aggregate. sequently, in striking find that the net balance between the two, we a gain in foreign-born population for the twelve months was less than compared with all back to and 200,000, years including 1908-09. or a meagre prior to 1914-15 The time does not to have arrived when the United seem Con¬ States, if de¬ velopment is to continue unhampered, should bar the out desirable immigrant. everything should be done to of any On the encourage contrary, the entrance and all of those whose efforts would be of assistance. And yet it is actually proposed, as we pointed out last week, to pass a law practically pro¬ hibiting immigration into the country for Would not that be more. alien The arrivals at a the a year or serious mistake? various ports United States for the twelve months ended June 30 1920 were the heaviest of any year We the years (141,132 previous year, than and 95,889 211,853 two preceding, 1,403,681 in 1913-14 and totals of in the four fiscal years with latest this a over a prior thereto. in the no however, the volume million Coincident much of departures Thus the net increase in foreign- population of 193,514 in 1919-20, while immigrants be said that of the arrivals can the number crossed the border from Canada than in by sea direct. aliens among came As to the distribution of arriving the various States, it is sufficient to that Texas, California and Michigan appeared say to have chiefly benefited. On the other hand, Penn¬ sylvania, Ohio and Illinois affected most were unfavorably by the heavy efflux of laborers. As regards occupations of the immigrant aliens who came the during the of all siderable children) over above the percentage were times, though, deficiency occupation no comprised The arrivals of skilled labor classes, however, of pre-war those with year, and women two-fifths of the total. in already stated, as ordinary labor, a con¬ including servants, is to be noted. Particular attention is called, in the Commis¬ sioner-General's report, to the work of his depart¬ ment in the matter of deportation of anarchists, communists and other undesirables. greater activity than before ever along these lines in the late Act of Oct. 16 1918 then having made witnessed was the year, Stating that passage more of the drastic the existing law, particular attention is directed to the arrests in November and December, 1919, and deportation of 249 undesirables to Russia on the the "Buford" refused on December 211919. entrance into the In all, the number country in 1919-20 11,795, of which close to one-half, 5,297 d for the purpose of financing American exports. Great Britain is even now demonstrating in wonderful fashion the soundness of her economic system; while France, Italy and Belgium, among our recent associates in the war, For practical purposes, presenting, before the world, noble efforts to "come back." There are enterprises abroad well able to offer security for our loans, care to extend them. Great Britain has shown the soundness of its are businesses and if in purchasing American goods. the Edge Act. in 700,000. been made to the similarities in Reference has and of its operations should already stated, as careful way. bringing the corporation into existence at an early date would be principles its plan and scope of operation. on large, small and beneficial, yet It may important that necessity be a it must not make unsafe position abroad. It is of considered large corporation would have every number of small a of most concerning the capital of the proposed corporation. While more must ficient $1,700,000,- report Edge corporations can $100,000,000 corporation with expert talent. large organizations. It would now times their capital and surplus. many law, because it is felt that such the banks Reserve $2,700,000,000 in discounts. and possible advantage over attract One word The Federal Reserve System made possible a great exten¬ financing. sion of 2379 CHRONICLE THE 181920.] we system lately by its steady progress in restoring economic in tion. Its exports so pared with through to its exports and France has made amazing progress in reconstruc¬ far this year have been two-thirds of imports, as com¬ balancing its trade. a in 1919; less than one-third and this has come about not fall in foreign purchases, but because the sales of French have more than doubled. products outside world the Taking the broadest possible view of the opportunity that is before us, as American bankers and business men, our duty seems now to be plain. It is, if I may be permitted to put it as I see it, to set up the machinery enable us to meet the situation that now exists, and shape that will that situation finance to our We are advantage. our presented with the opportunity to stable and permanent basis, trade with the outside world on a this great corporation which we have in provide for the most careful thorough credit investigation and the strongest commercial safeguards the interest of American capital. By means of this corporation we could through the instrumentality of view. By means of this corporation we could and in supply the materials to keep factories and mills running, in the interest of By means of this corporation our loans would be pro¬ tected, and we would lend in each individual instance only as we felt as¬ sured of the security of each particular loan. foreign customers. The action taken item at the meeting is dealt with in another in to-day's issue of our paper. European private individuals and Government undertook this task there would undoubtedly be objection on ground that taxes were being increased" for the entire country, or that loans were being floated primarily to promote the interests of the Government particular classes. demands that even if the Government is moved this work to meet the present emergency, it should abandon Every question of policy undertake to it just as soon as private financial machinery is brought into existence and. ready to operate. For just in proportion as we lean weakly upon the Government shall we cease to be independent and self-reliant. The more is seek to have the Government we do for us, the less shall we becom able to and business men, we should resist in every emergency. The more the Government extends aid to business, the more it must inject a larger interference in business. The President-elect has said that what we need is more business in Government and less Government in business. It de¬ do for ourselves. ' the habit As American bankers calling of for Government aid pends upon our actions as bankers and business men, the action of legislators, to bring this about. There are many no less than upon angles to the problems that we are here to discuss which briefly in these present remarks, which I detail before the day is over. In all our siderations, however, we must not lose sight of this overshadowing which is seriously affecting American prosperity to-day: much as the only been touched on hope be discussed in greater con¬ have may fact peo¬ ple in Europe, South America, Asia and Australia desire to trade with us, the existing premium on the American dollar is such that no one abroad can prudently borrow and agree to pay on short time. Hence, our export is languishing. There are many instances where American business have actually ceased to carry on business with foreign customers be¬ trade men cause of the disturbed exchanges; they cannot convert their accumulated into American dollars without suffering a severe loss. this corporation were to come into existence it could safely loan foreign funds If dollars, which in turn could be placed at el the American open up again the flow of our the disposal of the foreign debtor business concern with which to pay the latter and thus goods where they have now ceased to flow. OF FORMATION AMERICAN PRODUCTS EXPORT CORPORATION TO BUY AND SELL AND IMPORT COTTON. - According to the Atlanta "Constitution" of American Products Export capital of $10,000,000, was Dec. 7 the and Import Corporation, with a incorporated on Dec. 1 in Col¬ started cotton exportation to Germany. The new organization, it is stated, is intended to supplement the functioning of the Federal International Banking Corporation. Regarding the new organization the umbia, S. C., and immediately "Constitution" of Dec. 7 said: $10,000,000 The finance corporation, Texas, available export corporation, together with the $6,000,000 cotton belt, extending from Virginia to gives the 1,250,000 bales of low grade staple within the next six to Atlanta experts, who estimate that the $16,000,000 about ten times abroad months, according capital will afford capitalization of $16,000,000, or sufficient to sell that amount of credit facilities, or $160,000,000. International Banking corporation, formed had its hands tied so far as actually buying, selling and exporting cotton is concerned, leading financiers of the Southern States went to work with a will, and formed and incorporated the American Products & Export & Import Corporation, incorporated under the laws of South Carolina for $10,000,000, and with nearly $2,000,000 already sub¬ scribed. Already the export corporation is shipping cotton to the central Realizing solely powers, The that the Federal to finance exports, with future possibilities virtually unlimited. and the finance organizations are separate export in every way, but working for the same organizations object—the handling of the south's The export firm is working parallel to the financial organization, providing an immense, solvent export company, to actually handle sales abroad, while the finances are to be provided by the sister staple product, cotton. corporation. 3380 CHRONICLE THE Berry H. Collins. President of the Securities Sales Company of Atlanta, is In chaise of handling stock distribution in this section for the American Products Export and Import Corporation. He explained last night that while the Federal International provides banking facilities only, being for¬ Through the medium of the Federal International Banking corporation European buyers will be enabled to buy American products on better terms than heretofore; that organization actually buys and sells the cotton, the two organizations form¬ upon ing in a complete outlet, from the farmer who raises the cotton to the ultimate cotton Is not needed, the South itself handling cotton from anyway, planting it to collecting for its sales abroad, executing the Intricate trans¬ action from start to finish, Mr. Collins The American Products Indorsed and has the Federal Export Reserve Board, of the Atlanta Federal ernor Governor explained. and of South Carolina Washington, G. P. has B. Wellborn, Gov¬ Richard I. Manning, former President of the Corporation; is very weak because of the low rate of foreign exchange. other Southern financiers and business men. exchange rates, the natural result will be The formation of the corporation was the outcome of a meeting in Wash¬ At that time Mr. Harding could not promise the Southern bankers adequate financial help, the Stock Southern cotton industry. Mr. Manning undertook the eagerly subscribed by farmers, merchants and business was South Carolina. Originally the capital amount almost had been raised without task. men of $2,000,000, but when this was set at South going outside of South Carolina, the extended this week to North Carolina. was The campaign Georgia is next in line. is not taken by banks, but rather by farmers and merchants. Stock The capital stock of $10,000,000 is divided into 1,000.000 shares at $10 par value each. The corporation already is accomplished fact and an going a concern. It is market seas for the every South's increasing quantities, reopening the over¬ other large centres of industry. The Federal International the Banking Corporation does not hold cotton primary consideration, but desires to product for commodities produced in this section. cover all Cotton, being the foremost of as the crop the South, however, will receive the corporation's full support and of help, but will not be allowed to obliterate Interest in other commodities. What Is feared is congestion of stocks through the inability of European a buyers to continue purchases under the rules of the existing credit system of short-time payments. With mills and factories closing down in every part of the United States, the condition confronting American merchants at the present moment is of a most perplexing nature. means for elimination of the difficulties is essential, Non-consumption by and consequently markets foreign unnatural reduction an Some immediate according to the pro¬ accumulation means of prices, would produce irreparable stagnation, particularly to turn, which, in in Southern in¬ dustry. The stimulating effect upon every staple. the The small exporter, the private banker or the indi¬ case. vidual in any allied business is invited to subscribe and become a supporter of the system which is being successfully used in Chicago, New York and America, shipments will be made in Nathan Adams of primarily desired by the organizers to avoid the impression that link between the shipments of cotton to Germany already have been made, and hereafter bank of Houston, organization welcomes merely the support of the large financial interests. moters. Initial longer large scale. on a National Commercial Texas With the granting of its charter Dec. 1 the company formed the connecting Southern producer and the European consumer. are no betterment in a Dallas and Henry Hart of the City National bank of San Antonio. promoters saw their way clear to capitalize for $10,000,000, which was done. The sale of stock is progressing with whirlwind results. pending congestion of products which Among the organizers of the Federal International Banking corporation J. P. Caldwell of the Fort Worth National bank, J. A. Pondrom of the and he himself suggested the formation of a great export corporation, by and for it ruin a are Such Is not the ington of Southern bankers, Oct. 7 with Mr. Harding. The danger to producers lies in the fact that if foreign customers permitted to make their purchases in America, Hollins Randolph, General Counsel of the Federal Reserve Bank of Atlanta, and numerous of the Interests of American producers depends the security and strength of their foreign buyers, which, at this time American been Harding, Governor of D. C.; M. Reserve Bank; and Corporations The promoters of the corporation contend the first protection will probably carry with Import the active support of W. that is, on longer time credits than has been usual for American producers to grant. bidden to sell and buy commodities by Its charter, the American products ,buyer In Germany. Thus northern and eastern money, which isn't interested [Vol. 111. The improvement of the foreign exchange condition to offer the seems southern business, upon the whole industrial fabric of the South will soon be only escape for the American producer, and it is to attain that end that the felt in Federal International Banking Corporation is being brought into existence. big and permanent a way, Mr. Collins said last night. Connections have been established with European buyers, credits have been arranged, and already cotton has been shipped by the new corporation. Mr. Collins said: "The South business in what it has set about to do—to establish efforts and on its own initiative, the market facilities that have been needed so long, which heretofore the South has depended upon northern and eastern capital to provide. It means prosperity to Southern industry, and through it to every man, woman and child in the south. through its Mr. Collins explained that financial depression in the South has been directly due to the inability of the Southern farmer to finance the proper and orderly distribution of his crops especially cotton. In the past, he pointed out, the South has depended consuming were foreign capital mainly to finance upon But in the recent crisis the South had exports. every no help. Other sections dollar of their surplus in the development and struction of their industries and recon¬ Despite these conditions, Mr. resources. Collins said that never before has the South been fundamentally sounder or richer. He explained that the American Products Export and Import Corporation conceived solely by the financial and patriotic brains of the South to be financed and controlled by Southern business and farmers. men corporation, he explained in detail, will purchase and sell and also handle on a commission basis. to be Germany. Mills and labor there they cannot buy cotton, due until its idle, it was pointed out, because to prohibitive exchange rates and With $16,000,000 capital, command ten can Mr. Collins pointed out that the South times that much credit completely the industrial cotton crisis. Mr. or a a conservative estimate of 12% net earnings on capitalization, and the stock is distributed on a Maddox, President of the Atlanta National Bank, of Atlanta, Ga., who issued the call for the prelim¬ inary meeting rock-bound profit-sharing plan. Nov. 6, had the following to on inary meeting on the Atlanta to at Nov. 6, had the following according say to say (according "Constitution")—regarding that meeting— luncheon tendered a bankers in Atlanta to the Federal Reserve Bank of Atlanta on by officials of Nov. 9: The committee appointed at the recent meeting of the Southern delegates to the American Bankers' Association convention at coasider the organization of a foreign banking Act met in New Orleans last Saturday. Washington to further under the Edge company The committee invited representa tlve bankers from the cotton growing states to further discuss the plan come to some This definite conclusion meeting was one as to and the banks felt relieve the present It found was sell. States responsibility in taking some ever attended. a common cause, definite action to depressed condition in the cotton market. that with an estimated crop of 12,000,000 bales and a of 3,000,000, we would have, approximately 15,000,000 carry-over to their It bales thought that the consumption of cotton in the United was would and what should be done. of the most enthusiastic I have They all realized that in cotton the Southern bankers had not be bales to exported. as $160,000,000, solving Collins made F. Robert own account The greatest market is expected are now on The credit facilities. poor whole producers will be enabled to throw off their production. means own None of the so-called "blue-sky" laws of any state can be invoked. "Even if the War Finance Corporation should be revived it would be powerless to help without the functioning of such a corporation as the Ameri¬ can Products Export and Import firm. We are in this matter with our eyes open to the tremendous possibilities at last within our grasp." was Longer time credits, It is believed, will enable European buyers to purchase more of our goods and result in stimulating all markets. By such means American over As our 6,000,000, leaving, therefore, about 9,000,000 exports last year were only 6,500,000 bales, it deemed necessary to increase these exports in order not to have a large was carry-over into next year's crop. It was also found that there was a very large number of bales in the carry-over, estimated at 1,500,000 of low grade cotton for which there After a was but little demand in this country. full discussion of the entire demoralized condition of very our Southern products which include cotton, rice, tobacco, cotton seed products, ORGANIZATION OF FEDERAL INTERNATIONAL BANKING COMPANY TO FINANCE COTTON EXPORTS An over subscription $6,000,000 stock the of announced was Federal Dec. on International Company, plans for the organization of which under way at a Orleans on 10 to the Banking were brought meeting of Southern bankers held 6. The books of the company,which is intended to lend financial aid in the exportation of cotton'and other Southern products, were closed on Dec. 10, the State being reported as follows in the Atlanta Georgia $1,500,000 Louisiana 800,000 $6,350,000 issued last week, by R. S. Hecht, of New Or¬ leans, Chairman of the Campaign Committee, for of the Committee Orleans bringing the on a meeting Permanent organization to be held in yesterday (Dec. organization "Post" of the 11th inst. in into an 17) to complete operation. article The regarding the plans for Houston company financial institution that will be brought into being for the express of extending longer credits to foreign purchasers of the commodities produced In this section of the United States who treme low rate of now suffer from the ex¬ exchange. Headquarters of the Federal International Banking corporation will be Orleans, though branches and agencies will probably be established in the larger cities of the eleventh Federal Reserve district. when the South were not of the great prior to exports, a large part of actively in the market at this time, largely depression in their currencies and the difficulty they found in financing their to purchases on the customary cash 60 or 90 day basis. Many sections of central Europe are anxious to buy our cotton, but wish buy under present conditions on a 9 or 12-months' credit. There seems to be no was to existing machinery in this country to extend these credits, but it believed that purpose bank under the Edge Act, which was passed for a of facilitating just this kind of business, was the the practicable thing organize. subscriptions to the capital stock of the proposed company—to serve as name'a list directors and take immediate steps to pro¬ the charter from the Federal Reserve Board, which, under the law, have the direct supervision of the operations of the company. will '4 This committee made its report Saturday night, and it was unanimously adopted. It The report provided for a campaign to was Orleans, owing to the fact that it was the largest city in the South—the largest port in the South, geographically in relation It was be immediately organized subscriptions to close Dec. 10. unanimously decided to have the headquarters of the banking company at New to and the most centrally located the cotton-producing States. decided that the bank should begin business when there shall have been subscribed to the capital stock the amount of $6,000,000, represented by 60,000 shares of $100 per value each. It total It said in part: at New on account grade, in all of the Southern States, and the Total was arrived war consumed one-third of our cotton low were cure 500,000 Tennessee purpose European which of bankers who would 550,000 Mississippi A call time had The difficulty seemed to be that Germany and Austria, which the 1,500,000 Alabama a the should cooperate in a movement looking to the creating a demand for these 1,500,000 Texas.... It is decided that A committee was appointed to carefully draw resolutions expressing the opinion of the bankers present, and to fix a definite time for closing the "Constitution" of December 11: New was articles. at New Nov. subscriptions, lumber, etc., it was also decided that subscriptions $6,000,000 was was 4 should not be binding unless the subscribed. found that the capital and surplus and undivided profits of the banks in the cotton-growing States south of Virginia 000, and it was decided to request the banks to and surplus to the proposed bank. It was, of course, impossible to estimate how much would be subscribed by the banks lieved that a amounted to $472,000,- subscribe 3% of their capital in the South, but it was be¬ subscription between $10,000,000 and $15,000,000 would be received. Under the amendment to the Federal Reserve Act, permitted to subscribe / as much as 5% National banks are of their capital and surplus to an DEC. 18 1920.] THE organization of this character, State banks and a total of 10% CHRONICLE to such corporations. also allowed to subscribe to the stock in such enterprises. are The movement for the formation of the company had its inception at the annual convention of the American Bankers' Association, noted in these columns Oct. 23, page as was 1615, and Nov. 6, revive the activities of the War Finance Corporation, and that said corpora¬ tion be at once rehabilitated with the view of assisting in the financing of the exportation of agricultural and other products to foreign markets. Section 2. That it is the opinion of Congress that the Federal Reserve Board should take such action as may be necessary to permit the member banks of the Federal Reserve system to grant liberal extensions! of credit to the farmers of the country upon the security of the agricultural products 1807. page 2381 now held by them by permitting the rediscounting of such notes of extension at reasonable rate of interest. a EFFORTS OF A TLANTA COMMERCIAL EXCHANGE TO BANKERS1 SECURE PROPER STORING OF COTTON. A letter to the banks in canvass Georgia asking that they make of their customers and urge Commercial Exchange of Atlanta, Ga., with the hope that it will result in farmers who have been neglecting to store placing it under shelter or in a warehouse and avoid the heavy loss from weather damage incident to its being left out in the open for any extended length of time. The following is the letter which has been addressed to the banks by the Secretary of the Exchange, J. Hope Tigner. Atlanta, Ga., Interest of the State in regard to weather damaged cot¬ ton. All the cotton merchants of Atlanta have notified their road receive any weather damaged cotton, weather damage until the as men not to it is impossible to estimate the bale reaches its final destination the at mill where the total damage claimed by the mill is rebilled back to the cotton merchant making the shipment, who must suffer the loss. Weather damage can easily be avoided by the farmer placing his cotton under dry shelter up off the wet ground, or a more safely protecting It from weather, fire and robbery by placing every bale in There warehouse. the ground, absolutely unprotected, while the careless owner on promises every day to move say relative to the views of bankers posal to revive the War Finance Corporation: cotton showing as are declining to handle any weather damage. favorable attention from Congress, are not regarded with any degree of satisfaction by bankers here. Supporters of the scheme are occasionally to be uncovered in the financial district, but inquiry has established that, by and large, the better-informed banking opinion is opposed to it. The basis of the opposition is that at a time when the process of liquidation taken canvass of their customers normal a an footing is following perfectly natural lines, the organization designed to present an artificial obstacle to this inevitable movement have only harmful effects. can . The injection into the present situation of the War Finance likened to the of use pulmotor in a changed but merely deferred. Corporation is where the ultimate result is not a case In other words, it is felt that such aid as the War Finance Corporation could render would'only be temporary and that the attempt to check adjustment to a permanent basis in the particular quarters where this aid might be applied would react adversely upon the progress of the deflation movement, viewed in its entirety. scheme's advocates, bankers see tide over a no Even upon the part of the conviction that the plan can do more than temporarily difficult situation. Admitting this possibility, they raise the question whether relief of this character, which assuages but does remedy, is worth while, especially as it would Involve the reappearance of Government interference in a surely private financial situation. t"* Criticize Farmers. Bankers here inclined to be critical of the farmers of the country for are demanding the restoration of this Government They hold that the agency. experience of the farmer is similar to that which all classes of producers and The officials of the banks of the State are requested to make a personal their cotton, the pro¬ Prospects for the revival of the War Finance Corporation agitation for it under shelter, until weeks and months pass, the cotton merchants on which has been persistent, particularly upon the part of the farming com¬ munity, for some time past, and which now seems likely to command then the damage has been done and he will very probably find no market for his cotton at all, WAR not thousands of bales of cotton lying out in the winter weather are to-day, flat a REVIVE In its issue of Dec. 8 the "Journal of Commerce" had the resuscitation of We wish to call your attention to the very serious situation confronting you and the cotton TO following to and of return to 1920. 15 Dec. To the Bank Addressed— PROPOSAL FINANCE CORPORATION. them to properly house and protect their cotton has been sent out by the Atlanta their cotton VIEWS ON a immediately and urge thereby saving them further loss The cotton merchants and the supply them to house and protect that the farmer should "take his medicine." Now that class has made this demand, however, the feeling is that their crop. on distributors in this country are going through in greater or less degree and merchants will appreciate your personal interest in the matter. the agricultural its political power will influence Congress to act accordingly, with only the veto of the Presi¬ dent standing in the way of the Corporation's revival. If the War Finance Corporation becomes a functioning organization RESOLUTION FOR REVIVAL OF WAR again it is expected that it will be flooded with demands for assistance from all FINANCE sides, without respect to the justification of the requests. CORPORATION PASSED BY SENATE. left to themselves, would work out to The Gronna resolution, directing the revival of the War Finance Corporation, was passed by the Senate on Dec. 13. The resolution, which was introduced with the opening of a Situations which,'* satisfactory adjustment, will, it is be¬ lieved, be brought to the War Finance Corporation for solution. themselves, it was The banks asserted yesterday, might find it to their advantage to endeavor to transfer to the Corporation part of the frozen credits which are now hampering them, though recognizing the fallacy of the entire even procedure. . Congress last week by Senator Gronna, Chairman of the Senate Committee tion 1 'be at on Agriculture, directs that the Corpora¬ rehabilitated with once a view to EDMUND PL ATT OF FEDERAL RESERVE BOARD AP¬ assisting in the PROVES financing of the exportation of agricultural and other prod¬ ucts to foreign markets," and it expresses it as the opinion of Congress "that the Federal Reserve Bank should take such action banks . as . may to . the farmers." The be to permit necessary grant liberal the member extensions of credit to preamble recites that "there exists in the agricultural sections of the country unprecedented and paralleled distress account of the inability of the farmers to dispose of the on corn, other commodities un¬ wheat, cotton, wool, live stock and in marketable condition at .prices now that will pay the cost of distribution." The resolution it was was amended in several particulars before finally approved by the originally worded, it contained a Senate on Dec. 13. As mandatory provision direct¬ USE OF RESERVE BANK EARNINGS TO- AID LIVE STOCK INDUSTRY. Announcement was made Dec. 11 of the on approval by- Edmund Piatt, Vice-Governor of the Federal Reserve of a bill introduced of North Board, by Representative Young (Republican) Dakota, authorizing the use of $100,000,000 earn¬ ings of the Federal Reserve Banks to rediscount notes based live stock on quoted was The New York "Commercial" of security. Dee. 13 printed a Washington dispatch in which Mr. Piatt saying: as T?his bill provides for relief to the cattle raisers and the live stock indus¬ try in general and is, In my judgment, a practical, workable measure. It permits the Secretary of the Treasury to deposit in the Federal Land Banks in each of the years 1921 and 1922 $50,000,000 of the profits of the Federal Reserve system to be used to rediscount the notes held in banks based on livestock security, and these notes may be for terms as long as two years. It is obvious that the Federal Reserve banks cannot rediscount notes of ing the Federal Reserve Board to permit the granting of such long terms, as liberal extensions by member banks of credit to farmers "at by the member banks being the money of depositors and subject mostly the lowest to possible rate of interest." Norris, the mandatory provision of was On motion of Senator stricken out and instead requiring the lowest rates of interest, "a fair and able" rate reason¬ was proposed and this was accepted by the Senate. The following is the resolution as finally adopted by the their resources must be kept liquid, the money loaned payment on demand. The bill appears to me to be ing sound from and from the standpoint a standpoint public standpoint, from a bank¬ of the Joint resolution directing the War Finance Corporation to take certain action for the relief of the present depression in the agricultural sections which many of them are overloaded, will aid the farmers in other ways, for it will set free credit which will strengthen their reserves and Furthermore, the the purpose. made of the country and for other purposes. It also safe¬ agricultural districts by this method of taking care of the cattle paper, with to extend further accommodation on the security Senate: farmers. Incidentally, the relief afforded to many banks in guards the Treasury. sum The bill of money appears to enable them of other farm produce. made available is enough to accomplish me to be in accord with the suggestion by Governor Harding of the Federal Reserve Board in a recent hearing. Whereas, There exists in the agricultural sections of the country unprece¬ dented and unparalleled distress on account of the inability of the farmers to dispose of the corn, wheat, cotton, wool, live stock and other commodities now in marketable condition at prices that will pay the cost of production; and * /■- Whereas, to The people of Europe are in dire need of the agricultural Whereas, Under an Act of Congress there was established the War Finance in May, were 1920, by an order of the Secretary of the Treasury; suspended and, Whereas, The banks of the country are unable to extend credit to the n a products may be held until they fair and reasonable market; can be sold therefore be it Resolved, By the Senate and House of Representatives of the United States of America in Congress assembled, that the Secretary of the Treasury and^the members of the War.Finance Corporation are hereby directed to Board in AND GOVERNOR surplus, when, it is contended, "the Fed¬ eral Reserve banks should be sending out purposes all adopted at a the surplus meeting on money they by several hundred cotton farmers. resolution and "for his criticism higher prices." for crop-handling can spare," were Dec. 6, at Fayetteville, N. O., held the Federal Reserve Board was cotton for HARDING. calling upon the banks of the country to send in their cash Oct. 31 1920, on the basis of daily Treasury statements, was reduced to $24,062,609,672 96, of which about $2,337,000,000 consisted of loan and tax certificates unmatured. On Sept. 30 1920 the gross debt had been $24,087,356,128 65, of which about $2,347,000,000 were loan and tax certificates unmatured. On Nov. 30 1920, after the issue of $232,000,000 of Treasury Certificates on Nov. 15 and the re¬ tirement on the same date of about $100,000,000 of maturing certificates, the gross debt, on the basis of daily Treasury statements, amounted to $24,175,156,244 14, of which about $2,475,000,000 represented floating debt (loan and tax certificates unmatured). These temporary increases in both gross debt and floating debt will, it is expected, be more than over¬ come by Dec. 31 1920, in consequence of the December operations, and both gross debt and floating debt should on Dec. 31 be reduced below the amounts outstanding on Sept. 30. The Government's further progress in retiring the gross debt and the floating debt will depend, of course, upon the relation between current receipts and current expenditures during the coming calendar year, but there is good reason to hope that, unless new burdens are imposed by legislation, there should be important further re¬ ductions in the last two quarters of the current fiscal year, provided always that tax receipts are maintained at a sufficiently high level, salvage opera¬ tions vigorously pressed, and the strictest economy practiced in Government expenditure. The three months which have passed since the last quarterly tax payment period have been marked by a still further distribution of Treasury Certificates among investors and a further reduction of holdings of Treasury Certificates by the banks. The reporting member banks of the Federal Reserve System (about 823 member banks in leading cities, which are believed to control about 40% of the commercial bank deposits of the country and to have subscribed in the first instance for perhaps 75% of the Treasury Certificates of Indebtedness now outstanding) held on Nov. 26 1920 only about $313,000,000 of Treasury Certificates, as compared with reported holdings on Aug. 27 1920 of about $430,000,000, Certificates which matured on Sept. and Nov. on 1919 of about $816,000,000. 28 On Dec. 2 1920 the reported that there were pledged with Federal Reserve banks use Treasury Certificates as convenient following: it Includes the federal only about $214,000,000 of Treasury Certificates to secure loans and dis¬ counts, notwithstanding the preferential rates still maintained in many of the Federal Reserve Districts and the probability that borrowing banks would Besides Messrs. Lamont and Davis, of whom 22 are women. Reserve banks of the Treasury Houston; Governor Harding, of the Federal Reserve Board; former President Taft, Cardinal Gibbons, Charles W. Eliot, Frank A. Vanderlip, Cleveland H. Dodge, James A. Farrell, Paul 8. Secretary Senator Hitchcock of Nebraska, Senator Harrison, Mortimer L. Schiff, John D. Rocke¬ feller, Jr., James A. Stillman, Dean Shailer Mathews of the University of Chicago, Dr. Jeremiah W. Jenks, Charles H. Sabin, Frank I. Cobb, Adolph S. Ochs, George M. Cohan, George Horace Lorimer, Samuel Gompers, Dr. Livingston Farrand, E. N. Hurley, Julius Rosenwald, Festus J. Wade, Charles Nagel, John R. Mott, Dr. William Mayo, Myron T. Herrick, Louis W. Hill, Robert Dollar, John H. Rosseter, David Starr Jordan, Raymond B. Fosdick, Bishop Thomas S. Gailor, Mrs. Carrie Chapman Catt, Mrs. Medill McCormick wife of the Senator from Illinois, Mrs. George Wharton Pepper, Mrs. Blanche Bates Creel, Mrs. August Belmont, Mrs. Cary T, Grayson, Mrs. Joseph Cudahy, Mrs. Otto H. Kahn, Miss M. C. Thomas president of Byrn Mawr College, and Mrs. Margaret Anglin Hull. C. Vance Reinsch, McCormick, of Kansas, Fairfax Capper Lamont had the Mr. shall "We liminary telegram to the members of the committee, and all the machinery of a so-called to set in motion like profits taxes. The certificates now offered are also ac¬ ceptable in payment of Federal income and profits taxes payable at their option to call them for redemption before maturity. With these features, the attractive rates of interest, and absolute security of principal and interest these certificates are extremely desirable investments arid should prove particularly attractive to taxpayers having taxes to pay in the calendar year 1921, as well as to persons having idle funds awaiting investment. In these circumstances, the Treasury believes that banking institutions generally should feel free to enter subscriptions for the two issues now offered with the confident ex¬ pectation of prompt resale for investment, and urges them, as in the past, respective maturities, and the United States reserves no subscribe liberally the widest 'drive,' and without put¬ committee. I want to of this committee are in sympathy with the present effort, under Herbert Hoover's relieve the starving children of Europe. Many of us are identi¬ ting too much of a burden upon the members of the make especially clear the fact that all the members deeply very direction, to Hoover's committee, so that every effort with fied Mr. one work have for America will be made to supplement that of the other. The feeling in the Chinese people, the admiration for their industry, their of mercy honesty, and for their ment is so strong distress will be efforts to work out stable and progressive govern¬ that I am sure that the response to their present terrible adequate." collateral to secure loans for Certificates fo the two series now offered are exempt, calculating obtain have pointed out President's REPRESENTATIVE Certificates outstanding, from all State and local taxes (ex¬ cept estate and inheritance taxes) and from the normal Federal income tax and the corporation income tax and are admissible assets for the purpose to for the certificates apd devote their best efforts to possible distribution among investors. Cordially yours, D. F. TO A ON GOVERNMENTS AGRICULTURAL INTERESTS. statement showing the present country and the necessity House on Dec. presented to the tee, in order to show the Finance Commit¬ futility of postponing the payment quarte^y^doffiF'tfo. payments due Dec. 15. of the "to reach the ear of those who are We want every man Mr. principal object of his address McCumber stated that the asking favors of He added: and every corporation who must be called upon to alone upon their own discomforts but also the for taxes to look not country's dire need. We want the soldier, who is asking on a bonus bill, to exercise patience and forbearance action APPEAL IN BEHALF OF FA¬ of North 10 by Representative McCumber, Acting Chairman of the Senate Dakota, was financial status of the for immediate cash to meet the needs of the Government was pressing the Government." HotTSTOBr, Secretary. McCUMBER FINANCES—TAX POSTPONEMENT AND AID remit PRESIDENT WILSON'S we I have already despatched a pre¬ this matter. possibility of securing from the country an adequate response to the appeal for the Chinese famine sufferers without undertaking the other Treasury of organization that outline shortly the simple to be able mind for handling in have following to say on the 10th inst. of the committee: regarding the plans commercial purposes. The Treasury numbers 130, committee apponted by the President The of the operations incident to tike Ii consequence ury [VOL. 111. CHRONICLE THE 2386 for immediate and to under¬ financial difficulties that confront Congress. And we want appropriation committees to cut to the bone and to keep appropriations down to the limit of the bare necessity of Government. This is no time even to dream of new Governmental projects which will call for Treasury stand the grave our MINE-STRICKEN I CHINA—T. W. LAMONT TO DIRECT WORK. ' disbursements. appeal to the American people to "respond as An can" to the call for relief in they behalf of the famine-stricken peoples of China was made in a statement issued by Presi¬ The President stated at the same dent Wilson on Dec. 9. time that "in order to be assured of the orderly collection of such donations, large or small, as may be offered, I have invited nation-wide committee to lend their aid to a Thomas W. Lamont, matter." made chairman of the been the President's statement committee. The following is in the matter: alarming in its proportions, to-day A famine, this of J. P. Morgan & Co., has holds in its grip several The crop failure is complete, and the present distress which is great, is likely, before winter has run its course, to become appalling In fact our diplomatic and consular agencies in China inform me that the loss resulting from death in distressing form may run into millions of souls. It is certain that the local Governments and established agencies of relief are unable to cope with the magnitude of the disaster which faces important provinces in China. them. Under the circumstances, Once an more relief to be effective should be granted quickly. generous response with which call of their brother nations in distress. prompt and The •f of China I case our show that they have invariably met the opportunity is offered to the American people to regard as especially worthy of the earnest attention Chinese people look to us for friendship. Our churches, through their religious their schools and colleges, and our philanthropic have rendered China an incalculable benefit, which her people To an unusual degree the citizens. counsel and for effective and medical missionaries, foundations recognize with gratitude and devotion to the United States. Therefore not only in the name of humanity but in that of the friendliness which we feel for a great people in distress, I venture to ask that our citizens shall, even though the task of giving is not to-day a light one, respond as they can to this distant but appealing cry for help. In order to be assured of the orderly collection of such donations, large or small, names nated be offered, I have may as are committee, invited a nation-wide committee, whose their aid to this matter. I have desig¬ New York City to act as chairman of this and Norman Davis, Under Secretary of State, to act as treas¬ attached hereto, to lend Thomas W. Lamont of urer. I realize that those for the underfed children of East¬ afflicted peoples of the Near East, and to the needs of the demand upon the bounty of the nation. however, that all these pleas will be answered in generous this call, added to ern Europe and the our own I am country, makes heavy confident, •pirit. efforts to re¬ proposal to ask Representative McCumber referred to the vive the War Finance Corporation and the the latter "in some way to of Europe so we can finance the bankrupt countries export our wheat to them"; he his state one (North Dakota) exception, in a been crop failures, of twenty-three banks, all, with and he said that so far as the would seem that "the first, real, the sensible thing to be done, pipe, stop the importations and is to close the intake give the American farmer exclusively the American market so the market at had agricul¬ section of the country where there tural situation is concerned, it the like¬ reference to the closing in wise included in his remarks a long as he can supply We take from the "Congres¬ living prices." sional Record" his remarks, as follows: delegations who have been impor¬ tuning members of the Finance Committee for a meeting to consider the postponement of the December 15 installment of taxes, and also to devise a method of reducing those taxes. I had expected to ask permission at the close of the routine morning business, to present some figures upon this proposition, so that those, interested in the question could for themselves judge whether or not it would be possible for the Congress to grant them the relief they sought. Inasmuch as there are only four days to elapse be¬ tween now and the 15th, and we do not seem to be approaching the end of the morning business, I am going to ask the unanimous consent of the Senate to present, at this time, some of the figures showing the present financial status of the country, and the necessity for immediate cash to meet im¬ President, there are quite a few Mr. mediate needs. Committee on Fi¬ individually have been worked over¬ time in receiving delegations who, in presenting their urgent appeals for remedial action by the Congress, are reflecting the deplorable condition While there has been no meeting nance, that and no action by the the members of that committee is general throughout the country. are two features of the general situation | where the demand is for important, is our agricul¬ tural collapse; the second, the heavy inventory losses due to rapidly falling prices, for which relief is sought by (a) postponing the December 15 in¬ stallment of the tax on 1919 profits and income, and (b) by allowing the inventory losses of 1920 to be offset against the profits of 1919, and to that extent, reducing the amount of the December 1920 installment. While no one ean speak for the final action of the committee, or of the Senate or There immediate relief. The first of these, and most DEC. 18 1920.] 2387 CHRONICLE THE House, on these proposals, it is eminently proper, and, to my mind, most urgent that the taxpayers directly interested and the country at large be of informed at the earliest fore of about 2% war-savings certificates mature January 1 1923, loan and tax certificates mature within the year. possible moment of the present financial situation the country, to the end that the probability or of to especially true ment of taxes, I wish, which December falls due therefore, to present of the National meet able they may exercise their own judgment as possibility of securing the relief demanded. This is demand for the postponement of the last install¬ It is that whole is not a ; >mount of cash in Treasury Dec. 6 1920. this $160,018,235 Dec. 15 tax installment, estimated fiscal not wish to take Treasury, its immediate obligations, and its cash assets to them: Now, with 650,000,000 Total Outstanding certificates maturing Dec. 15 1920 $700,000,000 Maturing Jan. 3-15 1921 300,000.000 Maturing Dec. 15 1920 near and far, staring us in the striving to find some way by which we can relieve the agricul¬ We hope for some kind of relief through a revival of the are 140,000,000 ask this War countries of ness Total .$1,140,000,000 low Thus, Mr. President, if every dollar of the December 15 installment is paid in full and the last cent in the Treasury, including the comparatively small amount that will and which will be far governmental be there expenses, from secured still be would left by the that even milked deficit Secretary the of Treasury $250,000,000. the on places January 15 past-due safe basis a ' $579,981,765. But even three must add this we this gigantic deficit, added to this whatever sum and January next. day of $2,000,000,000, and I ask to have leaves He on June 30 with us 1921 of Gronna: money 60.193,375 all, what expenditures: $4,851,298,931 it would Mr. -$7,914,742,515 Excess of estimated expenditures over estimated receipts... Mr. $2,114,984,140 00 1921.................$1,755,037,119 67 250,000,000 00 Estimated gross deficiency June 30 1921—— $2,005,037,119 67 year 1922: Fiscal Year 1922. Estimated deficit In general fund June 30 1921 (as above)... $1,755,037,119 67 Estimated receipts: Ordinary $4,859,530,000 i— Public debt... — exclusive of — ployees, count of -$4,919,730,000 and of ; em¬ expenditures a very same banks furnish to me in reliable credit. that so far j the agricultural situation is con¬ as the he ian supply that market at living prices. Would not that result in depriving the people of Europe so long as If Europe can sell products? universally trade with a country where the balance of to in our favor and against that country unless that country balance of trade somewhere else. a now is to take care of our own people if we can. -"'.v. . we are thereby relieve the depression, when the depression is growing contin¬ Mr. McCumber had inserted in the "Record," as part of ac¬ additional his remarks, certain tables, as follows, covering points cussed by compensation ditures Dec. 15 tax installment, con¬ struction in Navy.. —$160,018,235 1920-——— Amount of cash In Treasury Dec. 6 account of new dis¬ him: in Postal Service, and of expen¬ on these ually by enormous imports into the United States. expendi¬ Government can seeking to export this wheat to Germany and Austria and to finance those countries in some way so that they can buy our exports tures on account increased com¬ pensation depression, how Senator considered that matter? McCumber: Oh, Mr. President, there is no question but what we is always Now, expenditures: Ordinary, come Has the bushels. 60,200,000 Total... Estimated That must But our first and impending They can not sell their products. We are seeking through a Governmental board to provide means by which we can export these products to foreign countries, when, as a matter of fact, the same products are coming into this country in un¬ precedented quantities. Why, I call the attention of the Senator from Minneapolis to the fact that during the month of October alone about 10,000,000 bushels of wheat, including flour, crossed the Canadian line for Minneapolis. - During the month of November I |am informed that that will run at least to 12,000,000 duty 1921 give the figures for the fiscal of the general plan to get money purchasing power to purchase our get can Estimated amount necessary for balance in general fund June 30 to seem cannot continue trade now now agricultural sections. nothing in this country, how can they be in a position to buy our products freely? Estimated deficit in general fund June 30 these foreign people to buy these farm products? For, after have, and what these country banks must is not Nelson: the of 3,063,443,584 — speaking in ! the Federal Reserve System. Reserve banks. the agricultural to a American market ——— State banks. pipe, stop the importations, and give the American fanner exclusively » in year, but not including Pitt- . are them belong to cerned, the first, the real, the sensible thing to be done is to close the intake $2,509,- Total of am is money and th|e credit that is not backed by cash somewhere So Act certificates) that if they were to these farmers must the background $5,799,758,375 outstanding maturing with¬ I wish over the 550,500 certificates of indebted¬ man so; present conditions should continue, it Now, if these banks cannot supply associate banks with money sufficient $359,947,020 33 have, ness Federal these they No; I situation the finance to to tide (including safely do can President None Gronna: McCumber: $5.739,565,000 debt Agriculture I McCumber: Mr. from Ordinary on '■ L ■'U yield to my colleague. hope my colleague will not get the impression that the banks closed had been extended credit from the Federal Reserve Board, Mr. Estimated receipts: Public they as I Mr. On page 273 and following is a summarized estimate of receipts and expenditures Estimated The testimony of Mr. Harding, Governor whole banking system. Mr. McCumber: Gronna; 23 for the fiscal year 1921, as follows: Total further because that is not the true condition. FINANCIAL STATEMENT, Public debt secure no Board, taken before the Committee far as our Mr. 4From report of Secretory of the Treasury for the year ended June 30 1920.] Ordinary can the whole is to the effect that the reserve banks have ex¬ on Mr. years: Balance in Treasury June 30 1920 section of the a Many other banks would have been closed further extend those credits and the 1922 of nearly $1,500,000,000. printed the report for these two fiscal they themselves until banks. get the money? we Forestry, JIT. June 30 on can might endanger difficulties. deficit a in the banks of this section have had to extend years reserve tended their credit our vision along a vista in¬ half calendar years, from the 1st two and a or I think, exception, one years former the Federal Reserve of Jfhe Secretary, in his annual report, directs years, the over Where is Bringing the total deficit immediately confronting us to $1,229,981,765. Mr. President, this is the situation, and it is the deficit that meets our cluding two fiscal with all, were four years. or except for assessments upon stockholders. to make good deficits growing out of Governmental operation,of railroads, estimated by the President in his annual message at $650,000,000. our President, in my State 23 banks closed during the past three weeks. credits from the necessary But it is not the end of tank But of live banks credits which requires immediate liquidation, does There must be busi¬ our now During each of those sum, ■/:v not disclose the full truth. immediate gaze. are These r-', ;v,v: on we were country where there have been crop failures, whole or nearly | whole, for the minimum of safety cash of • Therefore, to keep the Treasury If "and not statesmen"—we would fol¬ say would at least close the intake to we " v/: f.v'y. i considering the financial situation. What the farmer needs on until he can get a half living price for his crop. What the country bank needs is money to loan this farmer. assumption that the Treasury is as finance the bankrupt to way some hereafter. We making his calculations and estimates In in export our wheat to them. struggling to empty the tank through the spigot. were is money to which brings the deficit or amount which must be raised in some manner to we Mr. based is dry—is left bankrupt. Corporation so we can business instinct and our that general obligations of $329,981,765. But Finance Europe men—possibly I ought not to while general internal revenue sources than offset by the amount paid out for more sum. both deficits, activities of the War Finance Corporation. While wheat and wool are pouring into this country in unprecedented volume, driving down the prices of the American product to half the cost of producing it, we are about to immediate liabilities: our these great tural situation. $810,018,235 to now we gloomy view of our industrial prospects, but if 1921 as the last two months of 1920 a most decided improvement over a will not be one-half of that revenue face Turning worthy of note that the Secretary bases his estimate of the deficit on June 30 1922, on the assumption that our revenue for year will be $4,859,530,000, or nearly $5,000,000,000. I do which will exist 15. most general statement of the conditions a $7,500,000,000 of 23 of the Secretary's report. / page to the as and $2,847,000,000 of Within a period there¬ ending May, 1923, there will become due and pay¬ Government war obligations. I call attention to years, estimated--- 650,000.000 - —————— 3,897,419.227 Public debt Total 465,854.865 —- —— — Outstanding certificates maturing Dec. 15 Total..... Maturing Jan. 3-15 1921 4,363,274,092 Excess of estimated receipts over estimated expenditures Estimated deficit in the general fund June 30 1922 565,455,908 00 ——$1,198,581,211 67 Maturing Dec. 15 1920——— Total — $810,018,235 1920--——.$700,000,000 300,000,000 ——— 140,000.000 s -————$1,140,000,000 — Estimated amount necessary for balance In the general fund June 30 1922.... 250,000,000 00 Deficit (with empty Treasury) Estimated gross deficiency June 30 1922 $329,981,765 250,000,000 - Minimum Treasury safety balance...——... —— $1,448,581,211 67 $579,981,765 , Now, Mr. President, the estimated receipts and disbursements for the year ending June 3 1922 do not include deficits which must be taken care of during the coming year. 000,000. will be as nearly double that amount, October 31 On cate As nearly The President estimated for the railroads $650,I can learn, this deficit, when all claims are in, 1920 there were or about $1,126,000,000. still outstanding and unpaid tax certifi¬ obligations of the Government due from December 15 1920 to March If we carry the tax certificates to September 15 1921, of $506,527,500. 15 1921, the total will be $1,782,040,000. cates which become 432,950. I call If we include the loan certifi¬ due within the year, this total will amount to $2,629,- attention to page 22 of the report of the Secretary of the Treasury. Here is an About important feature which we ought to take into consideration. $4,250,000,00p of Victory notes mature May 20 1923, $800,000,000 Railway-operation deficit Total In deficit addition — — — we take the ——— following from the 650,000,000 $1,229,981,765 "Record," covering some of the further discussions in the matter: Mr. Simmons: The Senator in his very clear and comprehensive financial statement informs the Senate and the country that on the 80th day of the coming next June we will be confronted with a deficit of something over $2,000,000,000, as I understood him, and that on the 80th day of June, 1922, we will be confronted with a larger deficit. I want to Inquire of the Senator, who is the acting Chairman of the Finance Committee, and who, I understand, has Informally conferred with his colleagues in the ma¬ jority, if he has himself individually or in conjunction with his associates ; of the operations incident U the la consequence retirement of the Treas¬ IS 1920, and the quarterly payment of income and profits taxes on Sept. 15, the gross Certificates which matured on Sept. IS, and Oct ury 31 1920, on the basis of daily Treasury $24,062,509,672 96, of which about $2,337,000,000 consisted of loan and tax certificates unmatured. On Sept. 30 1920 the gross debt had been $24,087,356,128 65, of which about $2,347,000,000 were loan and tax certificates unmatured. On Nov. 30 1920, after the issue of $232,000,000 of Treasury Certificates on Nov. 15 and the re¬ tirement on the same date of about $100,000,000 of maturing certificates, the gross debt, on the basis of daily Treasury statements, amounted to $24,175,156,244 14, of which about $2,475,000,000 represented floating debt (loan and tax certificates unmatured). These temporary increases in both gross debt and floating debt will, it is expected, be more than over¬ come by Dec. 31 1920, in consequence of the December operations, and both gross debt and floating debt should on Dec. 31 be reduced below the amounts outstanding on Sept. 30. The Government's further progress in retiring the gross debt and the floating debt will depend, of course, upon the relation between current receipts and current expenditures during the Government the debt of statements, Oct. on reduced was to coming calendar year, but there is good reason to burdens are imposed by legislation, ductions in the last two quarters of hope that, unless new there should be important further re¬ the current fiscal year, provided always maintained at a sufficiently high level, salvage opera¬ tions vigorously pressed, and the strictest economy practiced in Government expenditure. The three months which have passed since the last quarterly tax payment period have been marked by a still further distribution of Treasury Certificates among investors and a further reduction of holdings of Treasury Certificates by the banks. The reporting member banks of the Federal Reserve System (about 823 member banks in leading cities, which are believed to control about 40% of the commercial bank deposits that tax the of 75% receipts are subscribed in the first instance for perhaps Certificates of Indebtedness now outstanding) held only about $313,000,000 of Treasury Certificates, as country and to have of the Treasury Nov. on 26 1920 compared with reported holdings on Aug. 27 1920 of about $430,000,000, and on Nov. 28 1919 of about $816,000,000. On Dec. 2 1920 the Federal Reserve banks reported that there were pledged with Federal Reserve banks only about $214,000,000 of Treasury Certificates to secure loans and dis¬ counts, notwithstanding the preferential rates still maintained in many of the Federal Reserve Districts and the probability that borrowing banks would use Treasury Certificates as convenient collateral to secure [VOL. 111. CHRONICLE THE 2386 committee apponted by the President The numbers 130, Besides Messrs. Lamont and Davis, of whom 22 are women. it includes the following: Houston; Governor Harding, of the Federal Cardinal Gibbons, Charles W. Eliot, H. Dodge, James A. Farrell, Paul S. Reinscb, Vance C. McCormick, Senator Hitchcock of Nebraska, Senator Capper of Kansas, Fairfax Harrison, Mortimer L. Schiff, John D. Rocke¬ feller, Jr., James A. Stillman, Dean Shailer Mathews of the University of Chicago, Dr. Jeremiah W. Jenks, Charles H. Sabin, Frank I. Cobb, Adolph S. Ochs, George M. Cohan, George Horace Lorimer, Samuel Gompers, Dr. Livingston Farrand, E. N. Hurley, Julius Rosenwald, Festus J. Wade, Charles Nagel, John R. Mott, Dr. William Mayo, Myron T. Herrick, Louis W. Hill, Robert Dollar, John H. Rosseter, David Starr Jordan, Raymond B. Fosdick, Bishop Thomas S. Gailor, Mrs. Carrie Chapman Catt, Mrs. Medill McCormick wife of the Senator from Illinois, Mrs. George Wharton of the Treasury Secretary former President Taft, Reserve Board; Frank Vanderlip, A. Mrs. August Belmont, Mrs. Cary T. Mrs. Otto H. Kahn, Miss M. C. Thomas of Byrn Mawr College, and Mrs. Margaret Anglin Hull. Blanche Bates Creel, Mrs. Pepper, Mrs. Joseph Cudahy, Grayson, president Lamont Mr. Cleveland had the following to say on the 10th inst. regarding the plans of the committee: outline be able to shall "We shortly the simple organization that we I have already despatched a pre¬ mind for handling this matter. in have members of the committee, and have pointed out possibility of securing from the country an adequate response to the President's appeal for the Chinese famine sufferers without undertaking to set in motion all the machinery of a so-called 'drive,' and without put¬ liminary telegram to the the committee. I want to of this committee are in sympathy with the present effort, under Herbert Hoover's relieve the starving children of Europe. Many of us are identi¬ ting too much of a burden upon the members of the make especially clear the fact that all the members deeply very direction, to that every effort will be made to the other. The feeling in the Chinese people, the admiration for their industry, their Hoover's committee, with Mr. one fied work have for America of honesty, and for their efforts to ment is so supplement that of mercy work out stable and progressive govern¬ the response to their present terrible strong that I am sure that so distress will be adequate." loans for commercial purposes. Certificates fo the two series now offered are exempt, like The Treasury other Treasury cept estate and inheritance taxes) and from the normal Federal income tax the corporation income tax and are admissible assets for the purpose offered are also ac¬ ceptable in payment of Federal income and profits taxes payable at their respective maturities, and the United States reserves no option to call them for redemption before maturity. With these features, the attractive rates of interest, and absolute security of principal and interest these certificates are extremely desirable investments add should prove particularly attractive to taxpayers having taxes to pay in the calendar year 1921, as well as to persons having idle funds awaiting investment. In these circumstances, the Treasury believes that banking institutions generally should feel free to enter subscriptions for the two issues now offered with the confident ex¬ pectation of prompt resale for investment, and urges them, as in the past, to subscribe liberally for the certificates add devote their best efforts to obtain the widest possible distribution among investors. calculating profits taxes. The certificates TO now A statement D. F. Houstojt, Secretary. GOVERNMENTS AGRICULTURAL INTERESTS. showing the present financial status of the / country and the necessity House for immediate cash to meet the needs of the Government pressing Dec. on 10 by Representative quarterly income tax payments due Dec. the reach the "to ear We want every man Commit¬ 15. Mr. principal object of his address McCumber stated that the was presented to the McCumber, of North of postponing the payment tee, in order to show the futility of was Acting Chairman of the Senate Finance Dakota, of those who are asking favors of He added: the Government." Cordially yours, ON FINANCES—TAX POSTPONEMENT AND AID and of McCUMBER REPRESENTATIVE Certificates outstanding, from all State and local taxes (ex¬ and every corporation who must be called upon to upon their own discomforts but also the remit for taxes to look not alone country's PRESIDENT WILSON'S APPEAL IN BEHALF OF FA¬ a CHINA—T. W. LAMONT TO DIRECT WORK. on bonus bill, to the grave stand our MINE-STRICKEN We want the soldier, who is asking for immediate exercise patience and forbearance and to under¬ dire need. action financial difficulties that confront Congress. And we want appropriation committees to cut to the bone and to keep appropriations to the limit of the bare necessity of Government. This is no time down even to dream of new Governmental projects which will call for Treasury disbursements. appeal to the American people to "respond as they An can" to the call for relief in behalf of the famine-stricken peoples of China was made in a statement issued by dent Wilson on Dec. 9. The President stated at the same time that "in order to be assured of such donations, invited a matter." nation-wide committee to lend their aid to this J. P. Morgan & Co., has Thomas W. Lamont, of of the committee. the President's statement in the The following is important provinces in China. The crop failure is complete, and the distress which is great, is likely, before winter has run its course, to several present become In fact our diplomatic and consular agencies in China inform me that the loss resulting from death in distressing form may run into millions of souls. It is certain that the local Governments and established agencies appalling of relief are unable to cope with the magnitude of the [disaster which faces them. Under the circumstances, relief to Once more an be effective should be granted quickly. The •f case our that they have invariably met the opportunity is offered to the American people to show prompt and generous response with which call of their brother nations in distress. of China I regard as citizens. To an especially worthy of the earnest attention unusual degree the Chinese people look to us for Our churches, through their religious their schools and colleges, and our philanthropic counsel and for effective friendship. medical missionaries, and foundations have rendered China an incalculable benefit, which her people the United States. Therefore not but in that of the friendliness which we people in distress, I venture to ask that our citizens shall, even though the task of giving is not to-day a light one, respond as they can to this distant but appealing cry for help. In order to be assured of the orderly collection of such donations, large or small, as may be offered, I have invited a nation-wide committee, whose names are attached hereto, to lend their aid to this matter. I have desig¬ nated Thomas W. Lamont of New York City to act as chairman of this committee, and Norman Davis, Under Secretary of State, to act as treas¬ recognise with gratitude and devotion to in the name of humanity only feel for a great urer. I realize that this call, added to those for Europe and the our own I am the underfed children of East¬ afflicted peoples of the Near East, and to the needs of the demand upon the bounty of the nation. confident, however, that all these pleas will be answered in generous ern country, makes heavy spirit Representative McCumber referred to the the latter "in some way to finance the bankrupt countries export our wheat to them"; he of Europe so we can wise included in his remarks a reference (North Dakota) his state one exception, in a efforts to re¬ Corporation and the proposal to ask vive the War Finance been crop failures, and he like¬ to the closing in of twenty-three banks, all, with section of the country where there had said that so far as the agricul¬ tural situation is concerned, it matter: its proportions, to-day holds in its grip famine, alarming in A of the orderly collection large or small, as may be offered, I have made chairman been Presi¬ would seem that "the first, intake American farmer exclusively the American market so long as he can supply the market at living prices." We take from the "Congres¬ thing to be done, is to close the the real, the sensible pipe, stop the importations and give the Record" his remarks, as sional follows: delegations who have been impor¬ tuning members of the Finance Committee for a meeting to consider the postponement of the December 15 installment of taxes, and also to devise a method of reducing those taxes. I had expected to ask permission at the close of the routine morning business, to present some figures upon this proposition, so that those, interested in the question could for themselves judge whether or not it would be possible for the Congress to grant them the relief they sought. Inasmuch as there are only four days to elapse be¬ tween now and the 15th, and we do not seem to be approaching the end of the morning business, I am going to ask the unanimous consent of the Senate to present, at this time, some of the figures showing the present financial status of the country, and the necessity for immediate cash to meet im¬ Mr. President, there are quite a few mediate needs. by the Committee on Fi¬ individually have been worked over¬ time in receiving delegations who, in presenting their urgent appeals for remedial action by the Congress, are reflecting the deplorable condition While there has been nance, that no meeting and no action the members of that committee is There general throughout the country. are immediate two relief. features of the The first general situation where the demand is for and most important, is our agricul¬ of these, rapidly falling the December 15 in¬ (b) by allowing the inventory losses of 1920 to be offset against the profits of 1919, and to that extent, reducing the amount of the December 1920 installment. While no one fan speak for the final action of the committee, or of the Senate or tural collapse; the second, the heavy inventory losses due to prices, for which relief is sought by (a) postponing stallment of the tax on 1919 profits and income, and Dec. House, 181920.] these proposals, it is eminently proper, and, to my mind, most the taxpayers directly interested and the country at large be on urgent that informed the earliest at of the country, to the ment I of which demand for the postponement of the due falls therefore, to present December ■ >■ mount of cash in Treasury Dec. 6 1920. installment, estimated t _■ war-savings certificates mature January 1 loan and v ; $7,500,000,000 23 It is $810,018,235 to that Outstanding certificates maturing Dec. 15 1920 $700,000,000 Maturing Jan. 3-15 1921 300,000.t)00 Maturing Dec. 15 1920....... 140,000,000 ...$1,140,000,000 ........... Thus, Mr. President, if every December 15 installment is dollar of the paid in full and the last cent in the Treasury, including the comparatively small that amount and which will governmental be will be far secured than more there expenses, from offset general internal revenue left by January 15 past-due obligations of $329,981,765. But the that even milked dry—is Secretary deficit left the of is based Treasury the on In assumption that the Treasury is calculations and estimates the minimum of safety cash of making his places as Therefore, to to keep the Treasury brings the deficit or on safe basis a must add this sum, we amount which must be raised in some manner $579,981,765. But even this gigantic disclose not requires" immediate deficit, which the full truth. There be must added to liquidation, does this whatever sum is to make good deficits growing out of Governmental operation.of necessary railroads, estimated by the President in his annual message at $650,000,000. Bringing the total deficit immediately confronting us to $1,229,981,765. Mr. President, this is the situation, and it is the deficit that meets our immediate gaze. But it is not the end of cluding two fiscal of January day years, or two and He leaves next. us half a difficulties. our ^he Secretary, in his annual report, directs of with I deficit a on June 80 1921 of 273 and following is On page a this low We are three Where can 3,063,443,584 and Forestry, further $1,755,037,119 67 Estimated amount necessary for balance in general fund June 30 250.000.000 00 1922: Fiscal Year 1922. Estimated deficit in general fund June 30 1921 (as above) ....$1,755,037,119 67 Estimated receipts: count of Mr. section of the secure can far no further Many other banks would have been closed The testimony of Mr. Harding, Governor Board, taken before the Committee they as safely do can on Agriculture banks have ex¬ reserve that if they were to should continue, it so; ^ > yield to 23 hope colleague. my my McCumber: the finance to I State banks. are them of belong to the Federal Reserve speaking am in situation Federal these they No; None Gronna: McCumber: these System. of the general plan to get money now That must agricultural sections. Now, if these banks cannot supply associate banks with money what to buy these foreign people to a For, after farm products? what these country banks have, and these farmers must background is not very a to seem Nelson: the reliable credit. that me long W 14,888.640 991.413,840 4s, U. S. Loan of 1925 2s U. 8. 1-year Certs, of Indebtedness 259.375,000 73,138.400 ward. Total 276,525,200 Dec. 18 The 1920.] THE following shows the amount of national bank notes legal-tender deposits Nov. 1 and afloat and the amount of Dec. 1 and their increase decrease or during the month of November. + Nat onal Bank Notes—Total Afloat— Amount afloat Nov. 1 1920.. Net amount Issued during November ... Amount of bank notes afloat Nov. 1 1920 Legal-Tender Notes— Amount CHRONICLE $732,549,629 1,461,168 Auction Sales.—Among other securities, the following, usually dealt in at the Stock Exchange, were recently sold at auction in New York, Boston and Philadelphia: By Messrs. Adrian H. Muller & Sons, New York: not Shares. 62 Metropolitan Surety_ 1 Social Reform Club V.v: deposit tc redeem national bank notes Nov. 1 1920...— $27,410,317 STOCK OF MONEY IN THE COUNTRY—The follow¬ ing table shows the general stock of money in the country, as well the as circulation holdings by the Treasury and the amount in given: -Stock of Money Dec. 11620 in U.S. . Gold coin (including bullion in Dec. 1 1919. $ $ k* ■■■■■* ■<■{■• 1 > Treasury)...........2,761,338,519 430,386,732 Gold certificates L. Standard silver dollars..... Circulation— Money in aHeld in Treas. Dec. 1 1920. $ 979,881,024 351.563,056 269,857,494 b879,529,142 415,692,081 15,857,417 97,095,305 82,416.283 155,289,410 157.6^2,692 262,917,134 1,615,362 Subsidiary sliver Treasury notes of 1890.... United States notes Federal Reserve notes 266,609,065 3,691,831 .... 346,681,016 c3,663,592,795 239,569,800 Federal Reserve Bank notes National Bank notes...... 327,488,796 6,962,414 339,718,602 18,203,857 3,319,415,118 2.839,814,899 4,094,172 235,475,628 205,470,544 13,130,555 720,880,242 677,814,786 734,010.797 1....8,281,659,486 492.327,078 6,363,498,999 5,929,874,791 This statement of money held in the treasury as assets of the Government does not include deposits of public money in Federal Reserve banks and in national banks and special depositaries to the credit of the Treasurer of the United States amount¬ a ing to $183,017,285 20. b Includes Mines Note.—On Dec. Federal 1 notes $898,841 309 gdld coin and bullion. $201,018,280 geld certificates and $325,973,820 Federal Reserve notes, a total of $1,425,833,409, on Dec. 1 1920. , > lot Banks.—The following information regarding national banks is from the office of the Comptroller of the Currency, Treasury Department: i Capital. $50,000 President, James H. Parker; Cashier, F. O. Wikoff. Original organizations: .' The Randall National Bank, Randall, Kans President, C. A. Crawford; Cashier, R. H. Parsons. The Woodbridge National Bank, Woodbridge, N. J...-. President, John F, Ryan; Cashier, Thomas B. Murray. Total _ 50,000 $125^000 . APPLICATIONS FOR CHARTER. # Conversions of State banks and trust companies: The Commercial National Bank & Trust Co. of Laurel, Miss..$100,000 Conversion of The Commercial Bank & Trust Co., Laurel, Miss., Correspondent, T. W. Yates, Laurel. Miss. The First National Bank of Seaside, Ore Conversion of The First State Bank of Seaside, Ore. Correspondent: The First State Bank of Seaside, Ore. ... 50,000 Painted Post National Bank, Painted Post, N. Y_. Correspondent: Charles Tibbetts, Hamilton and 25,000 Chemung fits., Painted Post, N. Y. The First National Bank of Fort Lauderdale, Fla Correspondent: Maxwell Baxter, Fort Lauderdale, The Farmers National Bank of Arlington, Texas Correspondent: J. E. Voss, Arlington, Texas. The First National Bank of Falmouth, Ky 100,000 Fla. 50,000 60,000 Correspondent: Geo. W. Berger, Falmouth, Ky. ..$385,000 CAPITAL STOCK INCREASED. i. *• '■ '•1 ••r- • $150,000 $300,000 VOLUNTARY LIQUIDATION. Carthage, Mo Capital $100,000 Liquidating Agent, W. E. Carter, Consolidated with Bank of Carthage, Carthage, Mo. The Carthage National Bank, To take effect Dec. 4 1920. Carthage, Mo. per share paid in liquid'n. $3 200 Mirror Films, Inc., pref...lot $20 1,100 Iona Gold Mining, Inc., lot $10 100 Plymouth Oil 7% pref.; 50 Plymouth Oil......lot $130 4,000 Loma Prieta Mines lot $31 50 Sijur Motor Appliance, 2d preferred.......... lot 19,500 The Petrogas Corp lot 34H Stlllwell Building, Inc..lot 12,500 Rexollne Petroleum lot 2,500 Rainbow Oil & Gas ..lot 25 Price-Campbell Cotton Pick¬ er Corp., pref.; 50 PriceCampbell C. P. $6 & Co., Inc., pref.; Waldes & Co., Inc., $100 C. Dlsbrow Co., Inc., pref.; 150 D. C. Dlsbrow Co., Inc., com lot $100 50 Southern A Atlantic Teleg..$15 100 Sixth Avenue RR ._$10H $50-$51 35 Federal Utilities, com_...$3-$3^ 15 Broadway & 7th Av. RR..S20 1920. 1919. Canada— Montreal. Dec. 1918. 1917. 136.972 ,026 167,028,108 108,930 ,543 110,131,036 Winnipeg 106,626 ,003 20,209 ,320 .. Vancouver _ Ottawa ... _ Quebec... 12,570 ,145 7.439 ,815 —18.0 139.320,268 —1.1 75,477,598 53,681,685 63,081,116 + 69.0 76,186,826 61.825,124 15,598,088 12,454,386 + 29.6 11.978,265 12.323,401 5,850,473 + 0.9 —8.0 4,094.883 6.857,302 + 6.4 4,965,870 9.550.301 + 8.3 8,020,597 3,288 ,059 Calgary + 22.0 5.480.300 7,289 ,368 10,339 .849 ... 6,099,587 5,044 ,717 Halifax Hamilton —9.7 2,393,637 5,646.541 76,727,405 9.685.169 3,955,929 1,985,000 4,808,166 London 3,745 ,759 3,642.214 4,347.859 —13.8 3,249,222 Victoria 8,466,209 1,958,513 2,222.243 3.046 .755 2 444.075 + 24.6 2,801.797 2.169.225 6.463 ,420 4.600,000 +40.6 3,972,023 3',344 214 5,336 .541 4,500,000 + 18.6 4 683.403 3.776.384 1 042 .958 John...].. Edmonton __ Regina .... Brandon + 1,058.664 —1.5 Letbbridge 1.047 ,457 749.185 + 39.8 816,181 884,821 Saskatoon 2,656 ,470 2,497,027 + 6.4 2.425,149 1,998,091 Jaw .. 906,802 764,750 2,601 ,395 2.028,068 + 28.3 2,554.387 1.506.170 1,662 ,992 2,102,640 1,000.312 —20.9 1.117,928 929,601 690.443 1 244 ,664 New Westminster 935 ,239 529,508 + 76.8 728 ,916 589,256 + 23.6 502,205 529.132 399.441 Medicine Hat Peterborough 1,052 ,771 + 19.8 949,614 608,262 Sherbrooke 1,175 .954 878,6*7 1,018.442 + 15.4 798.199 Kitchener 1,441 .651 + 2.4 756,404 3.550 ,337 1,407,646 2,200,000 540,895 684,597 + 65.9 1.155.865 613,,729 580,553 + 4.7 366,594 Brantford ...... . William.. ..... .... Windsor... Albert Moncton Total Canada 897,,017 Not fncl. in 457,056.853 432,454,320 + 24.4 Ferry 120 United Nat. Utilities, pref., with 60 shares common bonus 300 Smith lot $60 Motor & Truck Corp., temporary ctfs.lot $25 Huneke Co. 1,028,158 of America lot $10 712-5 Industrial Technics Corp lot $5 400 Splcer Mfg., common $1 125 Splcer Mfg., pref ....$40 6,000 Wawa Company... % Toronto St. Grand .$15-120 40 Martini Inc. or lot $100 100 Rock Island Co., pref 300 BlographCompany 106 Villa Park Assn. of lot $2 $4 ... Great Neck lot 34 Elmhurst South Realty $26 lot $6 25 Bronx Exposition, Inc., pref lot $5 250 Bronx Exposition, Inc., com lot $6 75 Sound Heights Corp .lot $10 25,262 Amer. Silver Corp 555 Nina Mines pf., Mines common lot $100 1,118 Nina lot $100 10 Theatre Parisien, Inc lot $2 91 Wilhurst Oil, Inc., com....lot $1 50 Wilhurst Oil, Inc., 1st pf.-lot $3 13 Reorg. Finance Corp lot $1 500 Atlan. Coast Fish., 1st pf_.$2.10 250 Gum Cove Oil & Ref__ $1 1,298 Aime Dupont Studios, Inc.lot $35 250 W. W. Boyer Co., com .$50 400 Federal Bakery, com $10 50 Gallaudet Aircraft Corp., com ..lot $14 . 691.149 total. + 5.7 368,922,392 250.141,516 cum. 40 Gallaudet Aircraft Corp., preferred lot $10 300 U. S. Chicle Refg., com...lot $40 75 Sound Heights Corp lot $10 100 Amer. Auto Accessories...lot $13 20,000 Crews McFarlan Mg., Ltd.lot $10 592 R. L. Rose Co., pref $1 500 Building Oper. Co., com..lot $15 80 Houser Royalty Synd $5 pref 50 Savold Tire Corp... lot $6 200 Caloris Mfg .lot $6 lot $7 154 Renova Fire Brick 15 Cohansey Glass Mfg lot $14 48 % Alaska Securities Corp lot $4 900 Smith Motor Truck, com..lot $8 50 Anglo-Amer. Comm'l Corp., preferred. v lot $12 25 Trac. Service Corp., pref..-lot $1 25 Tractor Service Corp., com.lot $1 150 H. B. Claflin & Co., com...lot $5 900 Realty Trust Co., pref 210 Wasson Piston Ring $10 lot $10 10 Nat'l Thrift Bond Corp. 4% $10 preferred.. 546 N. Y. A Nor. Shore Trac..lot $50 25 Coast & Lakes Contracting $105 lot Oil ...lot $25 1,000 Simpson, lot $100 Crawford 1st pref., 59% ation . 1,000 Simpson, 2d pref 500 Simpson, Corp., > paid in liquid- , -lot $23 Crawford Corp., Crawford Corp., ..lot $23 ...lot $23 common. preferred assented A Bowie 1,000 Snows Fountain Holding Corp. $1 100 Montana Farming Corp.,pf.$20 584 Nat. Tire & Rubber, com.. $1 St. 2,000 pref.; $10 171,000 Crews McFarlan Mining-lot $65 80 Le Zacualpar-Htdalgo Rubb.lot $1 276 New England Fuel Oil, com.$13 1,625 Chalmers Motor Corp. ass'd $1 166 2-3 Chalmers Motor Corp., common Week ending December 9, Oil. common 50 West Va. Trac. A Eleo. 7% common lot RR 20 50 Mitchell Motor Car of N. Y., Inc ....lot $41 ....lot $6 lot $17 50 Federal Utilities, pref pref.; InterOcean Submarine com....lot $50 600 Mays Oil; 100 Bowie Co. $31 8 Units Producers Develop..lot $17 2,000 Amer. Record. Laborator's lot $ 19 21 42d Clearings at— glneerlng, 1,000 Dayton Coal, Iron & Ry., common .lot $10 10 Inter-Ocean Submarine En- $50 20 Christopher & 10th St. RR.$10 Canadian Bank Clearings.—The clearings for the week ending Dec. 9 at Canadian cities, in comparison with the same week in 1918,showan increase intbe aggregate of 5.7%. Securities Corp. com.; $1,120 90 Continuous Tran¬ $25 common, V. T. C____._lot $50 100 Acme Harvesting M., com.lot $3 975 Hughes Petroleum ...lot $50 100 Internat. Fur Exchange, pf. $5 50 ... sit Secur. Corp. note Corp., 120 Green Motors, Inc 200 Cornella-AJo Copper lot $10 Speed A Traction Continuous Tran¬ sit $20 50 D. Ami. of Cap.when JtictcdSBo: Increased * The Waltham National Bank, Waltham, Mass.. 75 Security Bank of N. Y., $10 50 Waldes Total....... '• lot $45 pref., and scrip com.; 134 lot $100 5,864 Granville Mining, Ltd pref Original organizations: Prince $47 87 61 Multiple $100 5 Ptolemy Corporation lot $100 30,000 Triumph Gold Mining...lot $100 480 Tiffin Products, Inc lot $150 + 25,000 * Fort 4 San Luis Ry., $83 34 scrip; 14 San Luis Southern Ry. com., and 3,000 Burknett Van Cleave Oil...50c. 1,000 Northern Texas Oil.. 20c. 1,000 Mayfair Oil 10c. 150 New Haven Hotel. National CHARTERS ISSUED. Conversions of State Banks and Trust Companies: The First National Bank of Maroa, 111 (Succeeds The Citizens Bank If Maroa, 111.) $3 r common 250 com.; Estates 6% s. f. bonds, 1927; $390 Costilla Estates 6% ser. B scrip; $415 45 Costilla Estates 7% ser. A scrip. $100 lot 12 San Luis Construe., com.; 10 Theatre Parisien, Inc.,N.Y.Iot $5 53 Black Hawk Petrol., pref.. lot $85 Costilla Estates, pref.; $1,500 Costilla Corp $1 Co., Inc., pref.lot $5 Co., Inc., com.lot $5 12 SIbici Corporation lot $5 2,000 Wlnnemucca Mtn. Mining.lot $5 10,500 Cerro Gordo Mines lot $110 Clarborne-Annapolis Ferry.25c. lot $5 239 Costilla Estates, llo. 267Black Hawk Petrol., 1920 Federal Reserve banks and Federal Reserve agents held Reserve against $1,235,493,365 Moose Co. pref 75 General Bond & Share 100 Protection 300 lot $210 1,000 Eastland Co. Royalty Synd.lot $7 3,500 Florida Plantations, pref., with 2,190 shs. com $40 100 Connecticut Silica : Devel.; Creek ber Corp., com common lot $250 50 Denny-Renton Clay&Coal lot$100 2,000 Candelaria Exten. 20 The Esta Co., pref.; 16 The Esta Co., com lot $5 10 Bestol Co. com.; 73 Bestol 405 Potts-Meeker Realty.. $25 50 The British-Am Oil, com..lot $50 $403,542,320 39 Federal Reserve Gold Settlement Fund deposited with Treasurer of United States. ;+: ; c Includes own Federal Reserve notes held by Federal Reserve banks, d Revised figures. St. • 100 Protection Total against $1 1,000 Knick.-Wyoming Oil, pref.; 1,000 Knick-Wyoming Oil 1,702.266 Per share. Butte Chatham Mines, Inc., com.; 2 Chatham Creek Mines, Inc., pref.; 1,500 Co¬ manche Co. Oil; 5 Tex-LaHoma Oil Corp., pref.; 10 Tex-LarHoma Oil Corp., com.; 4,000 Louisiana Cal. Mg.; 100 The Republic Rub¬ $1 1,000 West Va. Consol. Oil lot $30 50 Am.Forelgn Trade Corp.,pf.$15 250 Am .For. Trade Corp., com. $1 500 Welte Mlgnon Corp. 7%,pf.$46 119 Interboro Rapid Transit...$43 241.951,420 Silver certificates.. 3 $1 juato lot $100 110 Ranger Royalties, Ino., pf. $1 500 Magdalena Oil Corp.......25c. Slocks. 2,000 No. 1 Automobile Co-op. Assoc.lot $1 + 1,400 King Edw. Sliver Mines..lot $40 ' 21 Waxement Co., Inc lot $5 1 Valsement Co., Inc lot $1 50 Deep Well Water Co lot $10 7,400 Quebec Devel., Ltd., of Can.$40 2,000 The United Mines of Guana¬ the dates on Shares. $5 lot * " . on lot 10 Water Wks. Construction .lot 10 Mehler Restaurant lot . Amount Per share. Clay Mfg., pref .$57.50 400 Shawmut Clay Mfg., com. $2.50 31 Oriental Bank.. lot $10 ..$734,010,797 .. Stocks. 683 Shawmut on deposit to redeem national bank notes Nov. 11920.... $27,817,444 Net amount of bank notes retired in November...................... ' 407,127 3397 lot $5 One-tenth Interest In Cayuna Ex¬ ploration Co. Synd., par value $7,500 Bonds. M. lot $500 Per cent. - $10,000 Carmen-Guanajuato 1st Is, coupons from Gold 1911.$100 lot $15,000 Guanajuato Consol. Mg. A Mill. 7% deben. for their conver¬ sion into stock; deposit receipt_$150 lot $17,500 Bering River Coal 1st 10year 6s $1,000 lot $50,000 Cent. N. Y. Southern RR. Corp. 1st A coll. trust bonds and stock accompanying same deposit receipt for subscrlp. receipt; 215 Cent. N. Y. Southern RR. Corp. pref. v. t. c. deposit receipt..$3,000 lot $15,000 Laurel Coal Mg. 1st 6e,1946$50 $1,000 Int. Garden Club 5s, 1945.$50 lot $6,000 West Caddo Oil Synd. 6% note, 1922; May 1920 coupon on . with 60 shs. stock as bonus...$200 lot Chicago Utilities 1st 5s, 1942, Oct. 1915 Coupon on...$150 lot $24,000 $10,000 Union Dye A Chem. Corp. 5s, adj. mtge. 1923, Dec. 1918 coupon on; 52 Union Dye & Chem Corp., v. t. c. and $8 75 scrlp__$30 lot $15,992 Sound Heights Corp. 6% notes _$15 lot $5,200 Metropolitan By-Products 3d 6s, Series A to I.... $75 lot $17,500 Mexican Govt. 3% internal silver bonds 10 K $18,618 Sound Heights Corp. notes$l 5 lot $5,000 National Co. (N. J.) frist lien 7s, 1925 90 $9,000 Metropol. By-Products Co. pref., note, 6%, ccrtif. of dep..$10 lot $47,000 Repub. of Panama 5s, 1944.$77 $50,000 County of Hudson, N. J., 4% park bonds, 1959 $81 $4,000 United Pub. Utll. 1st lien 6s, 1943.... J 50 $15,000 Savold N. E. participating 33% paid, leaving balance of 67% amounting to $10,050 $50 lot $32,000 Raritan Refining Corp. 7% participating 10-yr. gold bonds..$20 $6,000 Allegheny Valley Water first 5s, 1936 $40 lot $11,000 Virginia Southwest. Coal A Tinber first 5s, 1945 $15 lot $1,000 Sunnlngdale Country Club 1967... $21 lot income 5s, $700 Orange Lawn Tennis Club of N. J. 2d 6s $17 lot $2,000 Orange Lawn Tennis Club of N. J. 10-year 6s deb. notes $38 lot $5,000 Savannah A Atlanta Ry. 1st 1935 *10 $23,800 N. Y. A North Shore Trac. Co. 1st 5s, 1954 $550 lot 6s, $25,000 Coast A Lakes Contracting Corp. 2-year 6% notes $100 lot marks German Govt. 5s, dated 1915; Jan. '21 coupon on.$600 lot 50,000 [Vol. 111. CHRONICLE THE 2398 Bonds. Per cent' Per cent. 112 shs. Mass. Elec. Cos. pref. ctf. Mass. St. Ry. ref. 5s, dep. representing com. stock only 1948 25% flat of reorganization 3 shs. East. Maes. St. Ry. ref. 6s,% $7% $3.55 East Mass. St. Ry. Co. adj. adj. stock stock scrip* lot $34 Eastern Mass. St. Ry. ref. 5s, 6 shs. East. Mase. St. Ry. adj. stock $510 adj. stock scrip...—. —, 83 she.East.Mass.St.Ry.opt.warr't. lot $5,000 Nor. Mass. St. Ry. pf. 5s,'43 $180 $11.04 East. Maes. St. Ry. optional 150 shs. Texas Gas A Elec., com... warrant scrip lot 200 shs. Texas Gas A Elec., pref... $33.50 East. Mass. St. Ry. ref. 5s, 100 shs. Mase. Cons. Ry., pref . 1948, Series B 10,000 rubles Russian War Loan $1.08 East Mass. St. Ry. ref. 5s, 5%s, 1916 —.—$5 per M 1948, Series B scrip Bonds. By Messrs. Barnes % per sh. Stocks. Shares. & Lofland, Philadelphia: Bonds. Trust ($90 paid). 150 Bank of Camden.240 10 Nat. State Bank of Camden.214 150 Tlndel-M orris Co % 42 Empire Title A Trust, $50 ea. 24 1 Insur. Co. State of Penna— 80 17% United Firemen's Insur., 25 Norristown 7 First Nat. 10 Cemetery, $50 4 Chelten Hills $36 each.. Cemetery, $2 lot Phlla. A East on Elec. By., common lot Phlla. A Easton Elec. Ry 61 Mount Vernon each 192 108 $1 $4 lot $17 preferred Per cent. City Tramway 1st 28 fl.OOO United Iron Works, Inc., s. f. 7b. 1936 — 21 13.000 St. Louis A San Fran. RR. 5% notes lot $5 $10,000 Alaska Cons. Copper of Ariz, and the Alaska Corp. of Dela. 1st A coil. tr. 6s, 1927, with 1,000 shares common stock lot $60 $4,000 RiversideTrac. 1st 5s, 1960 - 43 $5,000 Am. Public Util. 6s, 1936— 42 $3,000 Qulncy Gas, Elec. A Heat. 1st cons. 5s, 1936 45 $5,000 Dallas Cons. Trac. Ry. 1st cons. 6s lot $32 $4,000 The Country Club of Harrlsburg, second incomes lot $200 $10,000 Georgia Light, Power A 17,000 Denver ref. 5s, 1933 11 10 $10 each 102 Philadelphia Life, $10 each.. 6 Scranton Life Ins., $10 each. $1,550 Eastern Series B, 190 150 9 6 20 2 10 12 4 37 27 100 2 120 200 Hardart Automat of pref Horn A Hardart Automat of 100 Horn A 4 Illinois, 50 1 5% 18 Philadelphia Bourse, pref— 20% 10 Phlla. A Gulf Steamship—.lot $1 20 Thatcher Spinning —100 % 7 Buck Hill Falls Co 100 100 Geo. B. Newton Coal, 1st pref .31% 425 Geo. B. Newton Coal, com.. % 20 Pa. A West Virginia Coal..-lot $10 1 Unit. Picture Theatres of Am. 5 1,200 Petroleum Corp. of Amer..lot $83 4 1-16 Western Land Assoc'n— 96 200 Pa. Ky. Oil A Gas. Refining. % 100 Tenn. Agrlcul. Chem., pref.. % 25 Tenn. Agrlcul. Chem., com.. A 6,667 Weldon Gold A Cop. Mining. 10c. 25 Bond Sandstone Briok lot $10 200 Standard Gas A Electric—lot $145 170 Edward G. Budd Mfg., pf.80%-82 12 The Autocar Co 96 60 UnionTrao. of Ind., 1st pref. 1 Illinois, common 4 Philadelphia Bourse, com... 20 Falls Motor, 70 A Power common (tr. ctfs.) 1% 50 Becker Milling Mach., pref. 45 66 Becker Milling Mach., com. 7% $6,250 Staked Plains Trust, Ltd A (Liquidation Certificate) (15% paid In llquld'n).lot $500 300 National Tool A Machine._ 1 3 Columbian Nat. Life Insur. 115 200 400 160 20 200 $2,000 Pitts. Term. Warehouse Transfer 1st 5s, 1936 gen. $4,000 Chic. 111. & 6s, 1947 $3,000 H ouston Belt A 6s, 1937. 1st 6s, 3% % 80% 1% Deposit of Md—105 420 Woodburn Oil 1 Fidelity & 6 Standard Gas A 3% Elec., com.. $400 $500 26,000 Pacific Tungsten, St. Incline 46 Ry. 2 84 60 500 lot $310 Vienna 5* lot $475 Republic of France, gium 5s 200 000 Kronen City of - Third War Loan, 4s —$42 per M. Telegraph. 1 New Hampshire Elec., pref— 2% 70,000 rubles Russian Government Internal 5%8, 1926_.$9%-$10 per M. Grlscom Hall Association..lot $5 Vulcan Motor Device. -lot $4 100,000 rubles Russian rentes 4 per cent (1894). lot $50 West Texas Sulphur ..lot $10 Nat. Underground Elec lot $2 By Messrs. R. L. Day & Co., Boston: $ per sh. Steam Cotton 195 240 U. S. Worsted, com., $10 ea_134 50 Boston Revere Bch. A Lynn. 42 300 Worcester Cons. St. Ry., 1st pref., $80 each 10 200 Mass. Elec. Cos., pref. ctf. dep. representing all sec. in I Shares. Stocks. Shares. 6 Naumkeag 3%~3% Mass. Elec. Cos., pref. ctf. dep. representing com. stk. only in reorganization 1.15 Boston Athenaeum, $300 par.561 Hood Rubber, pref 93% reorganization 167 1 63 300 Doane Tow Boat Co., $10 ea. 50 Becker Milling Mach., com.13 Kapo Mfg. 4 7a 10 Co each 26% 500 Amer. Invest. Sec., $10 each. 1.13 63 Mass. Real Estate 35 6 Boston Belting pref., $50 75 1,000 Blockhouse Mining, Ltd., $10 each .$10 lot 36 General Gas <fc Elec., con v. pf. 10 Dallas Electric, com 50 Quincy Mkt. C. 44 Rights Fall 2% 1 S. & W.,pf.76&dlv River E.Lt—50c.-51c. 10 50 Kapo Mfg., v. t. c 111 10 1 20 20 100 40 150 25 55 f lot Hopkins A Allen Arms, pref.. 1 $5 Hopkins & Allen Arms, com./ lot Lincoln A Parker Film, pref. 1 $10 Lincoln A Parker Film, com. f lot Nat. Society of Music, pref.. 1$1 Nat. Society of Music, com../ lot Penn. Gasoline, pref., $10 ea. 1% Roslyn Holding Co $10 lot Springfield Silver Black Fox, preferred $10 lot Co., pref Mot.Truck,temp.ctf_$10 lot 50 Stanwood Rubber, com 2 1,800 Shamrock Mining, trust ctf.$10 lot 100 Smith tr.ctf. Class 3l$10 tr.ctf. Class4/ lot 100 Nat'l Tool A Mach. Corp... 1 10 U.S.Mach.Gun 1 U.S.Mach.Gun Equitable Insur .$1 % lot Assn., $1000 each.. 650 flat 55 Carbon Steel, common 35 25 Becker Milling Mach., pref.. 45 42 New Eng. 27 Boylston Mkt. 85 Merrimac Chemical, $50 each (ex-div.) % per sh. Slocks. 8 Clawfoot Co., comm 8 Clawfoot 80 10 50 Gorton Pew Fisheries, pref.. 50 40 Electric Bond A Share, pref— 16 Kalbfleisch Corp., com pref—1$16 German Pub. Society, com../ lot Rights Fall River Elec. Light. 51c. 250 German Pub. Society, 100 12 Mill. 50 Becker with pref., Mach., ^ 50 Somerset Hotel Trust.. 50 Bay State Fishing, com 3 Gillette Safety Razor $40 lot 52 flat 7 130 P. 50 Haverhill Gas Light, ex-div.. 51% 50 Bonds. Per cent. each. 3 $6,000 State of Jalisco, Mex., 6s, 8,000 Combination Divide Mining, 1928, coup. July 1914 and subse¬ preferred $50 lot 8 Sirell & Simpson Biscuit, pref. 20 quent on. $190 per M 434 Plymouth Rubber, com $250 lot $3,000 Russian 6%s, 1919, ctf. dep. 13 $7,000 Eastern Mass. St. Ry. Ref. 150 MollieGibson M.&M., pref. 1 $10 20 Montpelier & Barre Lt. & Co., pref 100 The Royalty Synd., $10 5s, 1948, Ser. B, coupon July 1 Molliepibson M. A M., com.} lot 1920 on 25% flat Mining Co..J $5,000 Boston & Maine RR. 4%s, Hotel Trust 10 1929 62 50 The Pope Mfg., com $1 lot 100 Smith Motor Truck Corp $10 lot 500 shs. Fla. Soft Phosphate A Lime' trustees certif. for common }$10 10 No. Boston Ltg. Prop., pref. 70% $5,000 Fla. Soft Phosphate A Lime lot 100 American Motor Corp., com. 150 600 Carpenter-Cole 51 Oglethorpe 100 American Motor Corp., pref.}$10 lot —J A Dev..$5 lot 300 Big Drum Mining... $5 lot 100 Bingham Copper Boy Min__$1 lot 10 Berkshire Magneto $5 lot 2,000 Bingham Coalition Mines..$10 lot 25 Bay State Film, pref $25 lot 5 Units Cushing Devel $5 lot 5 Contin'l Mines,Corp.,Ser .A—$1 lot 100 Conn. Brass A Mfg. Corp..$25 lot 100 Chemical Copper, pref 1$15 200 Chemical Copper, com / lot 25 Amer. Motor Corp., pref. ctf. full paid stock 300 Bisbee Copper Min. int. $5,200 1st 6s, 1929 75 $6,000 Cons. G., E. L A P. 4%s, '35 70 $5,000 Canon Reliance Coal 1st 7s, Mar; 1 1929 ...30 flat $5,000 Nor. Ohio Trac. A Light 1st cons. 4s, 1933 50% $2,000 United Fuel A Gas 1st 6s, '36 82 $3,000 Utah Pow. A Lt. 1st 5s, 1944 75% $10,000 Detroit Edison conv. 7s, '30 92% $2,000 Worcester Gas Lt. 5%s,1939 83% $2,000 Joplin & Pitts. Ry. 5s, 1930. 55 $500 Continental Mines Corp. deb, $15,000 Boston Wharf 4s, 1941 Neb. 5 Commonwealth Power of 1st 6e, 1944 (Sept. 1920 coupons 20 on) $4,000 Bay State St. Ry. 6% notes (cert, of deposit) $10,000 East. Mass. St. Ry. 5s, 7%-9% '48. 25 Imperial Russian Govt. 36%s, 1919 1,170,000 franca N. Y. N. H. A H. RR. 15-yr. 4% European loan, $3,000 year 13 lot $51,000 5-year lot $20,000 Deposit of Bay State St. Ry. notes.-.lot $25,000 $10,000 Cucharas Land A Water Corp. 20-yr. 1st 6s, 1935 50% 1922 $200,000 Rhode Island Co. 5% notes, 1921— $240,090 40 Cert, of been paid. The dividends announced this week are: Per Cent. Name of Company. Albany A Susquehanna Books Closed. When Days Inclusive. Payable Canada Southern—————— $10 lot *1% Jan. ♦Holders of rec. Jan. Feb. Holders of rec. Jan. Dec. Holders of rec. Dec. 23 Jan. Feb. Jan. Dec. 18 to ♦Holders of rec. Jan. 16 *3% Feb. Holders of rec. Jan. 15 $5 ' $1 .25 Jan. 1% 18 Jan. Feb. Jan. to 4 26 *$2 Jan. ♦Holders of rec. Dec. 31 *1% Feb. ♦Holders of rec. Jan. 3 ♦$2 .50 Feb. Central ♦Holders of rec. Jan. 21 — 4 Jan. 1 Jan. 1% Holders of rec. Dec. 15a Jan. *6 Rensselaer A Saratoga Troy Union RR Jan. ♦Holders of rec. Dec. Francisco— ctfs.(qu.) Corp., pref. (qu.) — K. C. Ft. S. A Mem., pf. tr. Western Pacific RR. Street and Electric Railways. pref. (quar.)'. Dec. 25 3 Jan. Jan. 1 ♦Holders of 1% Jan. 3 (quar.) Cleveland Ry., pref. (quar.) ♦1% Eastern Texas Elec. rec. Dec. 20 Holders of rec. Dec. 16 Dec. 29 Dec. 30 ♦Dec. 23 to 1% Jan. 1 Holders of rec. Dec. 15a 2 Jan. 3 Holders of rec. Dec. 20a 3 Jan. 3 Holders of rec. Dec. 20a 1% —_ Co., com. (quar.) Preferred 16 Holders of rec. Dec. 1% — 2 22 Holders of rec. Dec. *1% Chicago City Ry. 31 Jan. to Bangor Ry. A Elec., pref. (quar.) Carolina Power A Light, pref. (quar.) Asheville Power A Light, Jan. 1 Holders of rec. Dec. — ; pref. (quar.) 15 Ridge Ave. Pass. Ry., Phila. (quar.) pref. (quar.) Wash. Bait A Annap. El. RR., com.(qu.) Pcwer A Light, Holders of rec. Dec. 31a 2 Holders of rec. Dec. 10a Jan. 1 Holders of rec. Dec. 15 Jan. Holders of rec. Dec. 15 *$3 Bonus 8 Jan. 1 (quar.) Ottawa Traction Jan. 1% 1 Monongahela Val. Tr., pref. (quar.) Northern Ohio Trac. A Lt., pref. (quar.) Jan. 1 ♦Holders of 1% Jan. 1 Jen. 37%c •1% (quarJ) West Penn Tr. & W. P., prff. (quar.) Yadkin River Power, pref. (quar.) York Railways, preferred 1% 15 Holders of rec. Dec. 16 I 1 Ho Id err of rec. Dec. 18a Feb. 1% 62 %c rec. 15 Jan. 3 Jan. 31 Banks. Holders of rec. Dec. 18« Holders of rec. Jan. Feb. 1% Dec. 3 Jan.? (quar.).-- Preferred 21 17 Holders of rec. Jan. 16 Holders of rec. Dec. Hold rs of rec. 2la Jan. 16 3 Chase National Holders of rec. Dec. 16 Jan. Holders of rec. Dec. 27a $2 (quar.) Chase Securities Corp Holders of rec. Dec. Jan. 4 Extra Jan. 3 Battery Park National Jan. Holders of rec. Dec. 27a Colonial ♦Holders of rec. Dec. 8 Jan. ♦Holders of rec. Dec. 20 *3 Jan. ♦Holders of rec. Dec. 20 4 Dec. *3 Coal & Ircn National (quar.). *3 (quar.) Extra Columbia 2 Extra Fifth Avenue (quar.) First Securities Co. Drc. Jan. 5 Jan. 10 (quar.) Jan. 5 Extra Greenwich Jan. *6 First National (quar.) Jan. 3 T Hanover National (quar.) Jan. 1 (quar.) Extra Jan. *8 Jan. Holders of rec. Dec. 21a Holders of rec. Dec. 21a ♦Holders of rec. Dec. Holders of rec. Dec. Mechanics' <!fc Metals Nat. 18 31a 3 Holders of rec. Dec. 31a Holders of rec. Dec. 31a Holders of rec. Dec. 20a Holders of rec. Dec. 20a ♦Holders of rec. Dec. 18 Holders of rec. Dec. 23a 6 Jan. *5 Jan. ♦Holders of r *2% (quar.) (quar.) Manhattan Co.. Bank of the c. Dec. 15 12 Mutual National City New Netherland National (quar.) (quar.) Jan. to Jan. 12 Jan. Holders of rec. Dec. 24 Jan. Holders of rec. Dec. 24 Jan. Holders of rec. Dec. 24 Holders of rec. Dec. 24 1 Extra National City Company to 4 (quar.) 25 'Dec. 25 5 (quar.) Extra ♦Dec. Jan. 10 Extra Jan. *10 Metropolitan (quar.) Public 3a Holders of rec. Dec. 24 3 ♦Holders of rec. Jan. Jan. *2 (quar.).., (quar.) Pittsburgh A Lake Erie. Utal 8 Jan. $1.25 Northern Pacific Illinois Traction, 3 reo. Jan. ♦Holders of *1% Mahoning Coal RR., common Preferred Louis-San 20 to 1% Louisville & Nashville St. 3 Jan. Dec. 21 - (quar.)——. Kanawha & Michigan (quar.) Little Schuylkill Nav„ RR. A Coal Northern ♦Holders of rec. Jen. Feb. Dec. 2 15a Holders of rec. Jan. Mar. *1% 25a Dec. "Holders of rec. Dec. 27 Jan. *3 River Tunnel Great Northern Michigan Central New York Central RR. Dec. 20a rec. Holders of rec 2 preferred Chicago Burlington A Quincy (quar.).— Clev. Cin. Chic. A St. L., pref. (quar.)„ Detroit Holders of 8 1 *3% Atlantic Coast Line RR., common Baltimore A Ohio, Jan. 2 •- (quar.) Ashland Coal <fc Iron Ry. — 7b, 1923 $4,000 St. changed the method of We have West Penn Power, pref. 12 shs. com. stock as bonus lot Per cent. Bonds. $33,000 Ports. Klttery A York Ry. 1st 6s, ctf. of deposit Railroads (Steam). $13 perM. of Berlin 4s. $ 13 per M. 50,000 marks City of Cologne 4s $12 per M 5,000 marks Kingdom of Bel¬ 1 Pacific A Atlantic 80 $1 each, lot $7,500 old stk.75c, 1% DIVIDENDS—Change in Method of City of Hamburg 60,000 marks City 10,000 francs preferred...2 Boston Arena, com., 6 Walker Potash have not yet 85 marks 25 36 Power 1 100 No. Sprlngf. Water 1st 5s, '28 5 1 Springfield Water cons. 5s, '26 56 Sprlngf. Cons. Wat. 1st 5s, '58 36 85,000 4Mb 30 784 60 72% A $10,000 Colo. Wyo. A Eastern gen. inc. 6s, 1944 $500 Buck Hill Falls Co. 1st 6s $900 30 Reporting Same. presenting our dividend record. We now group the dividends in two separate tables. First we bring'together all the dividends announced the current week. Then we follow with a second table, in which we show the diviends previously announced, but which of Venan¬ $1,000 Wilkinsburg A East Pittab. St. Ry. 1st 5s, 1929 $19,389 Commonwealth Power Ry. & Light 6% div. scrip A 6,000 So. Am. Gold A Platinum.— 45 Congoleum Co., pref 80 - 1935 Plane 1st 5s, Heat 1 1934 Seventeenth $1,000 65 Terminal 1st $6,000 Citizens' Traction go 1st 5s, 1942 $5,000Logan Co. Lt. 5 pref West. RR. gen. 200 20 Gorton-Pew 76 75 5s, 1943 500 43 Rights 585 Petroleum S3 34%-35% All Sugar Products, $10 each 2 Logan Johnson, Ltd., com., $50 each 10 Carbon Steel, common 35 Exceptional Pictures, pref.l lot Exceptional Pictures, com./$300 American Felt, pref 70 Saxon Motor Car Corp., Hawaiian 183 Am. 2,500 The Gas Allentown Bethlehem $5,000 - 100 Wash. A Va. Ry., 1940 $ per sh. 145 N. Bedf. Gas A Ed. Lt. Co. 144 3% of deposit 55 76 $25,000 Hotel Adelphla 1st 5s, 1922 96 $5,000 Nat. Conduit A Cable 1st 6s, 1927 51 Line RR. 1st 5s, 41 Tenn. Ry.. Lt. A Pow., pref. 2% Tenn. Ry., Lt. A Pow., com. % Standard Fuel., dom lot $8 Frankf. A Southw. Pass. Ry.200% Wash. A Va. Ry., com.(ctf.)_ 2% Wis., pref cert, $3,000 Amer. Gas deben. 6s, ser. A $2,000 Macon Terminal 1st 5s, 1956 Pipe A Construction Securities, pref —— 65% pref Mach'y.. Sheboygan Falls, 30 Brazil Companies lot $60 Fall River El. Lt—.40c. Fisheries, pref. 45 10 Commonw. Gas A Elec., pf. 62% 2,187 Aeolian Weber Piano A Pianola, com. vot. ctfs.. 12% 1,558 Aeolian Weber Piano A Pianola, pref 65 60 North. Conn. Securities 30 20 Ilium. A Pow. Securities, pf. 65 4 Ilium.&Pow.Securities, com. 10 30 Petroleum Heat A Power, pref. (tr. ctfs.).. lot $500 60 Amer. 310% The Laguna Co., 600 Standard Concrete 20 Ry. lot $25 RR. 10 $3,500 Delmar Water 1st 6s, 1933— 51 $300 Wildwood-Dela. Bay Shore 310 100 John B. Stetson, com 200 $2,000 Blanchard Ave. St. (Flndlay, O.) 1st 6s $10,000 Atlantic City A Shore 1st coll. tr. 5s, 1945 Trust 355 Stetson, pref.......125 5 Northwestern 35 John B. $ per sh. Worsted, com., $10 ea.1%-2 U. S. Worsted, 1st pref 54 Nyanza Mills ..104 East. Mass. St. Ry, 1st pf. 1 lot East. Mass. St. Ry., com.)$l,180 E. M. St. Ry., opt. war't.J Hudson A Manhattan RR. common (V. T. C.) lot 50c. Mass. Elec. Co's., pref. Stocks. 605 U. S. National Bank...240 Ry. 1st 5s, 1941 56 Lincoln Furniture, pref 150 $1,000 West Phlla. Pass. Ry. 2d Hallahan A Sons, Inc 65 5s, 1926 82 Girard Na tonal Bank 390 $29,000 Jamaica Estates 6s, 1920, Philadelphia Na lonal Bank.316 and 60 shares stock lot $100 Corn Exch. National Bank..380 Land Ti le A Trust 486% $2,000 Cin. Find. A Ft. Wayne RR. 5% ctf. of deposit lot $12 Pennsyl. Co. for Insur., &C.490 Real Estate Trust, pref 100% $3,000 Cleve. Elyria A Western RR. 1st 5s, 1920 10 Fidelity Trust .——413 $25,000 Ohio Syndicate lot $22 % West End Trust j 150 Commercial Trust 275 % $1,000 Colorado Mid. Ry. 4s, 1947 lot $5 35 Sou bwark Boston: Wise, Hobbs & Arnold,Stocks. Shares. By Messrs. Shares. <quar.)_ Jan. *2 •Tan. *2 Jan. Holders of rec. Dec. 24 Dec. Holders of rec. Dec. 4 ♦Pnldfr* of rec. Dec. 31 24 Dec. 181920.] THE CHRONICLE Per Name of Banks When Boole Closed. Cent. Company. Payable. Dave Inclusive. 3399 Per Name of (Concluded) When Books Closed. Cent. Company. Payable, Days Inclusive. Miscellaneous (Concluded) Holt, Renfrew A Co., Ltd., prei. (quar.) Home Bleach A Dye Works, pref. (qu.). 1K IK Jan. Holders of rec. Dec. 2 * Howe Sound Co. 5c. Jan. Holders of Jan. 2 $2 Jan. Holders of rec. Dec. 23a Jan. 2 Independent Pneumatic Tool (quar.) Special ; Holders of reo. Dec. 23a Jan. 3 Indiana Pipe Line.. $2 Feb. 15 Holders of rec. Jan. 24 Internet. Agric. Park, National (quar.) IK 1K /2 Jan. 15 Holders of rec. Dec. 31a ♦6 3 Jan. ♦3 Extra 3 ♦ Jan. 3 Seaboard National (quar.) Standard Tan. ♦6 Extra ♦1K State... 6 Dec. 20 28 Dec. 16 to Jan. 2 (quar.) (quar.) 6 Extra Jan. 3 Holders of rec. Dec. 20 4 Dec. 31 Holders of reo. Dec. 20 2 Dec. 31 Holders of Dec. 20 4 Dec. 31 Hold<rs cf rec. Dec. 21 4 Jan. Holders of rec. Dec. 21 Fidelity International (quar.).. 2K Dec. 31 Dec. 23 Jan. 19 Fulton 5 Jan. 3 Holders of rec. Dec. 20 2 Jan. 3 Holders of rec. Dec. 20 4 Dec. 31 New York (quar.) 8 Jan. Peoples, Brooklyn (quar.) 4 Dec. 31 Equitable (quar.) ... Extra Extra Metropolitan (quar.) 10 rec. to Holders of rec. Dec. Dec. 3 19 to Holders of rec. 17 Jan. 3 Dec. 30 Fire Insurance. Continental Insurance $2.50 Jan. 5 Holders of Dec. 27 Fidelity-Phenix Fire Insuranoe. 15 Jan. 5 Holders of reo. Dec. 27 reo. Miscellaneous. Abltlbi Power A Paper, Ltd., pref. (qu.)_ Advance Candy Mfg., pref. (quar.) Amer. Brake Shoe & Fdy., com. (qu.)._ Preferred (quar.) Amer. Fruit Growers, Inc., pref. (quar.) Amer. Gas A Electric, common (quar.).. Common (payable in oommon stock) Preferred (quar.) __ American-Hawaiian Steamship American Lace Manufacturing (quar.).. Am. La France Fire Eng. Inc., com. (qu.) Preferred (quar.) ... Amer. Power & Light, pref. (quar.) Amor. Seeding Mach., com. A pf. (qu.) American Type Founders, common (qu.) Preferred (quar.) ...., ... Anglo-American Oil Jan. 3 Holders of rec. 2 Jan. rec. 2 K f2. IK $2 2 Holders of Holders of rec. Dec. 21a Dec. 31 Holders of rec. Dec. 21a Jan. 3 Holders of rec. Dec. 22a Jan. 2 Holders of rec. Dec. Jan. 2 Holders of rec. Dec. 17 Feb. 1 Holders of rec. Jan. Jan. IK IK 1 Dec. 31 $1 3 Holders of rec. Dec. Dec. Dec. 31 16 to Dec. Jan. 15 17 15a 1 2K Feb. 15 Holders of reo. Feb. 1 IK Jan. 3 Holders of rec. Deo. 20 IK Jan. 3 Holders of rec. Deo. IK 18 Holders of reo. Dec. 31a Jan. 15 ♦1 Jan. 15 Jan. 10 *1K (t» Jan. 15 Jan. 10 Austin, Nichols A Co., pref. (quar.) Avery Company, preferred (quar.) Babcock A Wilcox Co. (quar.) 15 Jan. 1 Holders of rec. Dec. 22a IK Jan. 1 Holders of rec. Dec. Feb. 1 •Holders of rec. Jan. Dec. 22 Jan. to 15 1 Holders of rec. Dec. 20a Jan. 3 Holders of rec. Dec. IK Barnhart Bros. A Spindler— First and second preferred (quar.)— 1 Jan. 2K Baltimore Electric, preferred Baltimore Tube, preferred (quar.) Jan. 2 Jan. 1 Holders of rec. Dec. 20a •IK 1 15a (quar.)... (quar.) Feb. 1 20c. Jan. 1 Holders of rec. Dec. 20 20c. Jan. Beacon Chocolate, first pref. 1 Holders of rec. Dec. 20 Jan. 26 Beatrice Creamery, common (quar.) Preferred (quar.) Billings A Spencer Co. (quar.).. 4 Jan. 3 Dec. 21 to Jan. 2 IK Jan. 3 Dec. 21 to Jan. 2 5 Jan. 1 Holders, of Boston 2K Dec. 31 Holders of rec. Dec. 13a IK Jan. 3 Holders of "Wharf Brandram-Henderson, Ltd., pref. (qu.). Brier Hill Steel, common Preferred (quar.) rec. rec. Dec. 18a Dec. la 60c. Jan. (quar.) Brunswick-Ba'ke-Collender, pref. (qu.) Burt (F. N.) Co., Ltd., common (quar.). Preferred (quar.) California Electric Generating, pref.(qu.) Canada Bread Ltd., pref. (quar.) Canadian Car A Foundry, preferred Canadian-Conn. Co.'s Mills, pref. (qu.) 1 Dec. 21 to Jan. 2 IK IK Jan. 1 Deo. to Jan. 2 Jan. 1 Holders of rec. Dec. 20 w2K Jan. 3 Holders of rec. Dec. 15a Holders of rec. Dec. 15a 21 K IK Jan. 3 Jan. 3 Holders of rec. Dec. IK Jan. 2 Dec. tol x22K 18 to 18a Jan. 1 Dec. 31 Holders of rec. Dec. 24 23a Massachusetts Gas Cos., pref. (quar.).. Mathieson Alkali Works, pref. (quar.).. Maverick Mills, pref. (quar.) ; Mays Food Products, Inc., pref. (quar.) McCrory Stores, pref. (ouar.) Merchants Dispatch Transporta. (qu.). Merck A Co., pref.(quar.) ... Preferred *1 Jan. 15 ♦Holders of rec. Dec. 31 ♦75c. Jan. 15 ♦Holders of rec. Dec. 31 City Investing, pref. (quar.) Cleveland Worsted Mills (quar.)... Coca-Cola Co., preferred. Holders of rec. Dec. 15a Jan. 1 20c. Jan. Columbia Sugar (quar.) Extra 1 Dec. 21 to Dec. 31 10c. Jan. 1 Dec. 21 to Deo. 31 Dec. 30 Hclders of rec. Dec. 15a Jan. 1 Holders of rec. Dec. 15a *3K .... .50c Consumers' Gas, Toronto (quar.) 2K Preferred Shipbuilding, (quar.) Nov. 16 15a 15 Dec. 24 Dec. 26 Jan. 15 ♦Holders of rec. Dec. 31 Holders of rec. Dec. 18a 3 Detroit Edison (quar.) Etd.. nref. 30c. ♦2 IK Tan. *IK 3K Feb. 1 Jan. 15 Dominion Steel Corp., Ltd., pref. (qu.). IK Feb. 1 Donner 4 Dec. 31 Dominion Owners, (quar.).. Dominion Coal. pref. (quar.) Dominion Linens, preferred Steel, Inc., 1st pref Douglas (W. L.) Shoe Duluth Edison Eleo. Co., pref. (quar.).. Duquesne Light, pref. (quar.) Eagle A Blue Bell Mining Extra (from reserve for depletion) Emery A Beers Co., Inc., preferred ..... ... Dec. 24 ♦Holders of to rec. Jan..12 Holders of rec. Dec. 31 Jan. 16 to Feb. 1 Holders of rec. Dec. 20 3 K Jan. 1 IK Jan. 3 Holders of rec. Dec. 15 Holders of rec. Dec. 22 IK Feb. 1 Holders of 10c Dec. 23 15c. Dec. 23 rec. Jan. Holders of rec. Dec. 17a Holders of Dec. 17a Jan. 1 15a Dec. Empire Steel A Iron, pref Fairbanks, Mcrse A Co., com. (quar.). Famous Plavers-Lasky Corp., pf. (qu.). 3 Jan. 5 Dec. 15 Holders of rec. Dec. 3 Jan. 1 Holder* of rec. Dec. 20 $1.25 2 Jan. 3 Feb. 1 16 rec. 2 Second preferred (quar.) to Holders of rec. Dec. Holders of rec. Jan. 10c. *IK Flint Mills Feb.- ♦Holders of rec. Jan. •IK FiPk Rubber, Dec. 31 ♦Holders of rec. Dec. Deo. 25 Jan. 1 to Jan. Dec. 15 ♦Holders of rec. Dec. *S2 Alpaca (quar.).. Federal Motor Truck 1 (monthly) 1st pref. (quar.) ♦4 (quar.) Jan. 1 3 ♦Holders of rec. Dec. Dec. 25 to Jan. 15a 14 20 1 21 la 15 ♦Holders of rec. Dec. 15 ♦Holders of rec. Dec. Jan. 15 ♦Holders of reo. Deo. 20 Jan. Holders of reo. Deo. 22 Holders of reo. Deo. 23 Holders of rec. Dec. 24 Holders of rec. Dec. 2K Jan. Holders of rec. Dec. Jan. Holders of rec. ♦Holders of Jan. ♦Holders of rec. Dec. 31 Jan. Holders of rec. Dec. 22 Jan. Holders of rec. Deo. 27 ♦Hrlders of rec. Dec. 15 Jan. Holders of reo. Deo. 20 ♦1K *1K Jan. ♦Holders of rec. Dec. 15 ♦Holderp of rec. Dec 15 IK Dec. 23 Jan. 10 $1.25 Jan. Holders of reo. Deo. 18 Holders of Dec. 17 2 Jan. Holders of rec. Dec. 17 Holders of rec. Dec. 15a Second preferred (ouar.) — Screw, 27 27 Jan. ♦Holders of rec. Deo. 18 Jan. ♦Holders of rec. Dec. 18 ♦1 *$1 ;. Sullivan Machinery (quar.) Symington (T. H.) Co., com. ♦$1 30 ♦Holders of rec. TToldurS Of Tan. Dec. 20 Jan. ♦Holders of rec. Dec. 20 Jan. •Holders of Jan. ♦Holders of rec. Jan. rec. 15a Jan. Holders of rec. Dec. 15a *3 (quar.) Holders of rec. Dec. Jan. 4 Tidewater Oil (quar. TorHngton Co., common (quar.). Preferred $1.25 Dec. Tan. ♦Holders of rec. Dec. 20 31 1 rec. Dec. 11a Ho'ders of rec. Dec. 21a Held rt of Holders of rec. Dec. 10a Holders of rec. Dec. 87 Kc Dec. 24 24 Trayior Engineering A Mfg.— Common and 2 Trumbull Steel, com. (quar.). Common Preferred (extra) ... (quar.) - (quar.)..... Tuckett Tobacco, common Preferred (quar.).. Underwood Computing Mach., pf.(qu.)_ United Cigar Stores, common United Profit Sharing! ... Extra — (qu.). United Shoe Machinery, common Preferred U. S. (quar:) Jan. ♦50c. preferred (quar.) Jan. ♦Holders of rbc. Deo. 20 ♦Holders of rec. Dec. 20 1 Tan. Holders of rec. Dec. 31 IK IK IK Jan. Holders of rec. Dec. 31 Jan. Holders of rec. Dec. Jan. Holders of rec. Dec. 31a Holders of rec. Dec. lKc. Tan. lKc ♦Holders of rec. Dec. 20 ♦Holders of rec. Dec. Tan. Holders of rec. Jan. pref. (quar.).. Universal Leaf Tobacco, pref. (quar.)... Utilities Securities Corp., pref. (quar.) Vanadium Corn, of Amer. (quar.) Jan. Holders of rec. Dec. 31a 2 Jan. Holders of rec. Dec. 22a IK Holders of rec. Dec. Dec. TTo'df-n of 31 27 Holders of rec. Dec. 20 Holders of rec. Dec. 20 3 Dec. Jan. Jan. 2 Holders of rec. 2 Dec. 20a Jan. 2 Holders of rec. Ward (Edgar T.) Sons Co., com. Preferred (quar.) Dec. 20a Waring Hat Mfg., pref. (quar.) *2 2 Jan. 1 Warren Bros., 1st Dec. 31 ♦1K IK Jan. 3 Deci. 16 pref. (quar.) Second preferred (quar.)... Welsbaeh Co., preferred *1K IK Holders of rec. Dec. Dec. 16 to Jan. Dec. 31 Jan. 1 Holders of Western Union Telegraph ♦1K Jan. 15 ♦Holders of Jan. 1 IK Tan. Preferred (quar.) ... Preferred (quar.) Hall Lamp Hanes (P. H.) Knitting Co.— P* Preferred (quar.) Harris Bros. A Co., cref. (quar.) $2.50 IK ♦50c. IK •IK 3 17 Jan. 1 Feb. 1 Jan. 1 Holders of rec. Dec. 20 12 to Jan. 30 Holders of rec. Dec. 22a 1 Dec. 28 2 Heath (D. C.) Co., pref. (quar.)... IK Jan. 1.5c Jan. Dec. 24 ♦Holders of rec. Dec. Hartford Automobile Parts, pref. (qu.). (quar.) to rec. Dec. 24a Holders of rec. Dec. 24a Dec. 28 ♦Jan. Hendee Mfg.. pref. (quar.) to Dec. 31 Holders of Hillcrest Collieries, com. (quar.)... Preferred (one'*.) Jan. 3 Jan. 15 rec. Dec. la Holders of rec. Dec. 20 Holders of rec. Dec. 30a 1 Hecla Mining Jan. 15 Holders of rec. Dec. 30a IK Jan. 15 Holders of rec. Dec. 30a IK IK (qu.).. (quar.) Kootenay Power A T,t., pref. (qu.) Tan. Jan. Jan. Jan. DeC. 15 Jan. ♦Holders of reo. Dec. 24 Jan. •Holders of rec. Dec. *Holdnr<| of TOO. Tan. ♦$1.75 Jan. Westinghouse Air Brake (quar.) Wheeling Steel A Iron, pref. B Will A Baumer Candle IK IK 3K .... West $1 ♦3 Virginia Tron Coal A Coke 9 (quar.) 28 1 2 Jan. 3 Jan. IK Jan. 2K (quar.) (quar.).. Jan. Dec. 22 to Dec. 30 Dec. 23 to Jan. 1 1 Dec. 22 to Jan. 1 /50 IK ... Youngstown Sheet A Tube, com. (quar.) (ouar.) Dec. 20 2 Co., pref. (quar.) Wilson A Co., Inc., pref. Preferred rec. Holders of rec. Dec. ♦$2.50 Jan. Young (J. S.) Co., common (quar.) Common (payable in com. stock) Preferred Holders of rec. 24 Dec. 20 31 ♦Holders of reo. Dec. 31 - Jan. ♦$1.50 Jan. *1K Jan. Holders of reo. Dec. 18a Holders of reo. Williams Tool Corp.— Preferred 17a Dec. ♦Holders of rec. Dec. Jan. Great Lakes Transit, com. (quar.).. 3 Tan. IK IK 2 20 $1 Distributing Corp U. S. Industrial Alcohol, IK IK 14a 18a 23a Holders of rec. Dec. 23a Jan. ♦50c. Jan. *37 K ... ♦Holders of rec. Dec. 20 *12Kc Jan. Jan. *1K Holders of Gray A Dudley Co. (quar.) Great Lakes Towing, common (quar.).. 1 Jan. 1 to Dec. 20 50c. 2 (quar.)— (quar.) Tecumseh Mills Dec. Dec. 30 ♦Brifiors of rec. Dec. IK (quar.) (quar.) Extra- Dec. ♦5 com.(quar.) Jan. Goodyear TireARub. of Can, pf. Goodwins, Ltd., pref. (quar.) Goulds Mfg., common (quar.) Prfferred (quar.) 21 2 IK Jan. 2 31 *2 K — Preferred Preferred Jan. ♦3 ...... Standard rec. *2K pref.(qu.) Standard Safe Deposit (quar.).. Extra to Dec. 31 17a Dec. 21 2 IK Dec. 18 Jan. 3K rec. 18 21 ♦Holders of rec. Dec. rec. 24 Dec. Jan. Garvin Machine, preferred (qu.) Dec. 22 Holders of rec. Dec. •IK Dec. rec. Dec. 21 Crow's Nest. Pass Coal (quar.) Jan. 15 62 ♦Holders of Jan. Jan. Stover Mfg. A Engine rec. Dec, 15 Jan. 19 rec. rec. Holders of rec. Dec. Jan. Jan. rec. Holders of ♦Holders of rec. Dec. IK IK to Holders of Holders of rec. Dec. 31a 2 K 2 Holders of Jan. Securities Company 10 ♦Jan. ♦Holders of 17 ♦Holders of reo. Deo. 24 Jan. Simpson Creek Coal, pref. (quar.) Soden (G. A.) A Co., let pref. (quar.).. Jan. 1 17 Dec. IK ... Safety Car Heat. A Ltg. (quar.) Sheridan-Wyoming Coal *1K 1 Dec. to ♦25c. Jan. S'eel A Tube Co., pref. Farr (qu.)__ (quar.) 19 31 to 1 2 Jan. Dec. 1 Jan. ♦3 Prairie Pipe Line (quar.) to Jan. 31 Jan. Jan. ♦3 Price Bros, (quar.) 2 Jan. ♦Holders of rec. Dec. Jan. 25c. Jan. (quar,). Extra 10 ♦Jan. IK Jan. 15a Holders of reo. Deo. 31a IK com. (quar.) Jan. 2 Deo. 31 ♦3 Prairie Oil A Gas *2 Dayton Rubber Mfg., pref. (quar.) Detroit Creamery (quar.) to Jan. 2K 25c. Jan. ....... Port Arthur Southwestern Cities Elec. Co., Crucible 8teel, com. (quar.) 15 Tan. Creamery Package Mfg., com. (quar.). Preferred (quar.). . 31 ♦Holders of rec. Dec. 23 Jan. 3 Dec. 31 Dec. Jan. *1K Jan. IK Holders of rec. Deo. Deo. 25 31 ♦Holders of rec. Dec. 21 Jan. Panhandle Prod. A Ref., pref. (quar.).. »$2 Penn Central Light A Power, pref. (qu.) 800. 1 Dec. 20 Jan. ♦1 Pacific-Burt Co., Ltd., com Preferred (quar.) 1 rec. Jan. ♦1K Feb. Holders of reo. Dec. 27 Holders of rec. Dec. 20a IK ♦1K $T ♦75c. Jan, Owens Bottle Co., com. (quar.) Preferred (quar.) Feb. 3 ♦Holders of 15 ♦Holders of rec. Dec. 31 Dec. 31 Republic Motor Truck, pref. (quar.) Rogers (Wm. A.), Ltd., pref. (quar.) Dec. 31 17a Jan. rec. 25 21 Jan. 17 15 ♦Holders of Dec, 31 Dec. IK Holders of rec. Dec. Jan. Dec. Dec. IK Dec. 20a Hclders of rec. Dec. Jan. Holders of rec. Dec." 20a *2 Jan. 1 Extra Cleveland-Akron Bag (quar.)— Cleveland Automobile, pref. (quar.) Dec. 31 rec. 2 (quar.) 3 15 rec. ♦Holders of rec. Dec. 23 2 Ottawa Car Mfg. Bonus 3 15 27 20 Holders of Jan. Jan. 2 Dec. Holders of Jan. IK rec. Holders of rec. Dec. 20a 12 Jan. Jan. Holders of 31 Holders of rec. Dec. 22 Jan. Jan. 2 Dec. Deo. 31 ♦Holders of reo. Deo. *$1.50 Jan. Jan. IK Jan. IK *2 K to Jan. Reo Motor Car rec. Dec. 21 3 IK 15a rec. Jan. Dec. 24a 12 Dec. Holders of rec. Holders of rec. Dec. 31 Dec. Holders of Holders of rec. Holders of Dec. 31 Holders of rec. Dec. 22 2 . Holders of Dec. 31 Jan. Jan. Common and preferred (monthly) Holders of rec. Dec. 24a Dec. 31 IK 3 Reelcraft Pictures Corp., pref. A Cities Service- Dec. 31 IK 3 Ogilvie Flour Mills (quar.). Old Colony Woolen Mills, pref. (quar.). Oriental Navigation, 1st A 2d pf. (qu.)_. 15a to $2 Dec. 20a Hold' rs of rec. Dec. 15 Holders of rec. Dec. 24a rec. 2 10 31 ♦Holders of rec. Dec. 31 Dec. 31 rec. K Transportation (annual). reo. Dec. ♦Holders of J i $1 Holders of flK Gas . 23 15 ♦Holders of rec. Dec. IK Cincinnati Gas A Electric (quar.).. Cincinnati Jan Deo. 15 ♦Holders of Jan. rec. Jan. 15 Dec. 23 Dec. 2 ... Holderp •**! rec. Dec. 2 Central Teresa Sugar, common Preferred (quar.) Jan rec. ♦3 1 Central Coal A Coke, com. (extra).. Preferred (extra) *2K *1K H«dders of ♦3 ........ Jan. 15 Deo. 31 lan. Northwestern Yeast (quar.) Extra 2 *1 Deo. 31 to Holders of reo. Jan. *1K Canadian Locomotive, ^Preferred (quar.) ; to 22 Feb. Northwestern Electric, pref. (quar.) Northwestern Power, pref.. Pond Creek Coal (quar.). Extra ............ Extra 22 Dec. 25c Phelps Dodge Corporation (quar.) 15 Dec. Jan. 25c Extra Dec. 31a Dec. 23 Holders of rec. Dec. Dec. 23 ♦Holders of rec. Deo. Holders of rec. Dec. 20a Jan. *8 Nipissing Mines (quar.) Dec. ♦2 Dec. IK 2K National Fireproofing, pref National Fuel Gas (quar.) New York Oil rec. 20a 20 18 Holders of rec. Dec. 23 ♦50c Monatignol Rubber Works, pref. (qu.). Montgomery, Ward A Co., pref. (quar.) Narragansett Elec. Ltg. (quar.) rec. Dec. Holders of rec. Deo. *2K (quar.)....' Holders of rec. Dec. 31a rec. Holders of rec. Dec. Jan. I? ♦2 , Holders of Holders of rec. Dec. 20 Holders of rec. Dec. 20 Jan. $1.25 Dec; 31 (quar.) Midwest Oil, common Holders of Holders, of Holders of rec. Dec. 2Holders of rec. Dec. 31a 2 Maryland Coal 1 1 Holders of rec. Dec. 3 IK 15 1 ♦Holders of rec. Dec. 31 Dec. 23 Jan. IK 30 Jan. Jan. Jan. 2 Jan. Jan. 2 ♦Holders of rec. Dec. 31 50o. Jan. IK 14 2 Jan. 2 Jan. Jan. *1K 2K ..... IK (quar.) to IK 2 •; 19 Holders of rec. Dec. 24 IK 2 common Dec. $3 Canadian Explosives, Ltd., com. (quar.) Preferred (quar.) Castle Kid Co., Inc., pref. (quar.) Cement Securities (quar.) Jan. $1.50 Jan. 12 K c. Jan. Extra *• Dec. 24a Holders of rec. Dec. 24a Holders of rec .-Jan. IK Mac Andrews A Forbes, com. (quar.)... Preferred (quar.) Magor Corporation, com. (quar.) Common (extra) Preferred (quar.) Manning, Maxwell A Moore (quar.) 18a rec. 24a Dec. 31 Jan. *2 Extra Merrimac Chemical Jan. 2 Holders of Dec. 24a Feb. f 13K Kansas Gas A 15 Jan. rec. rec. 2 ... Eight per cent pref. (quar.)... Kaminlstiquia Power, Ltd Elec., pref. (quar.) Kerr Lake Mines, Ltd. (quar.) Kidde (Walter) A Co., Inc., pref Kolb Bakery, pref. (quar.).... Laurentide Co. (quar.) Lawyers Mortgage (quar.) Library Bureau, common (quar.) Preferred (quar.) Loew's Incorporated (quar.) Loew's Tbeaties Co. (quar.) Holders of 3 Island Creek Coal, com. A pf. (quar.)... Johnston (R. F.) Paint, 7% pref. (quar.) Dec. 20 *1K IK Astoria Mahogany, Inc., pref. (quar.).. Ault A Wiborg Co., preferred (quar.) Preferred IK Common (payable in com. stock). Internet. Mercantile Marine, pref. Inter-Coast Steamship (quar.) Dec. Jan. $2 Chem., pref. (quar.) International Harvester, com. (quar.).. Trust Companies. Brooklyn Columbia (quar.).. 20 Dec. Holders of rec. Dec. 27 Jan. 1 1 ♦Holders of rec. Dec. 20 ♦Holders of rec. Dec. 20 1 3400 Below and not THE we CHRONICLE [Vol.111. give the dividends announced in previous weeks paid. yet This list does not Miscellaneous announced this week. Cent. When Books Chout. Cent. Payable. Days Inclusive. 3X 3X Dec. 29 Holders of rec. Nsv.30 Atlantic Gulf A W Feb. 18 Holders of rec. Jaw. Jan. 2 Holders of rec. Dec. 2X Feb. 1 Holders of rec. Dec. 31a Associated Oil Preferred Albany A Susquehanna.— Atchison Topeka <fe Santa Fe, pre! Beech Creek (quar.) Boston A 2x Buffalo & Susquehanna, corn, (quar.) Common (extra) Preferred 15a 3 Holders of rec. Dec. Dec. 31 Holders of rec. Nov. 30a 50c. Jan, Albany (quar.) 20 30 15a IX Dec. 3 Dec. .30 Dec. 16 to Jan. 2 2 Dec. Dec. to Jan. 2 Dec. la — ——...— Canadian Pacific, oommon (quar.)— Chesapeake <& Ohio 30 Dec. 16 to 16 2H Deo. 31 Holders of ree. 2 Chicago Indianapolis A Louisville, pref, Chicago A Northwestern, oommon 2 Jan. Dec. 31 Holders of rec. Dec. 3o 2 Preferred Chicago Rock laid. A Pac., 0% pref.—„ Seven per cent preferred Dec. 30 Holders of rec. 2X 3X .... Jan. 16 Holders of rec. Dec. 15a Jan. 16 Holders of rec. Dec. 16a Dec. 22a 3 Dec. 31 Dec. 11 to Jan 3X Dec. 31 Dec. 11 to 2 Jan. 2 3 Dec. 23 Holders of rec. Dec. 2a 3X Dec. 23 Holders of rec. Dec. 2a Colorado & Southern, first preferred.. Second preferred...... ...—— 2 Dec. Dec. 19 to Jan. 2 4 Dec. 31 Dec. to Jan. 2 Delaware <fc Hudson Co. (quar.) Detroit A Mackinac, pref erred...... 2X Dec. 20 Holders of rec. Nov. 27a 2X Jan. 3 Holders of rec. Dec. 15a 2 Dec. 31 Holders of rec. Dec. 10a Cin. N. O. A Texas Pacific, common... Common (extra)....... _ Hocking Valley Illinois Central, leased lines • 31 19 Mobile & Birmingham, preferred Morris & Essex.. 2 Dec. 16 to Jan. 2 rec. Dec. 31a Jan. 3 IX Cotta, preferred.., (in pref. stock). Baldwin Locomotive Works, com. A pref. Barrett Co., common (quar.) Jan. 25 Holders of Feb. 1 Holders of rec. Dec. 20 Holders of Holders of rec. Dec. 10 rec. Dec. 15fl 4 r4X 3X 2 Preferred d\40 Dec. 31 Jan. Dec. 30a Jan. 3 Holders of Holders of rec. Dec. 15a Jan. 15 Holders of rec. Dec 30a 1 Dec.d3l rec. Dec. 4a Holders of rec. Dec. 15a IX Dec .<131 Holders of rec. Dec. 15a 2 Jan. 15 IX Jan. 3 Holders of rec. Dec. 31a Holders of rec. Dec. 15a Holders of rec. Dec. 15a $1 (quar.). com (quar.) Bell Telephone of Canada (quar.)., Bethlehem Steel, com. A Com. B (quar.) Seven per cent preferred IX Jan. Eight per cent preferred (quar.).. (quar.). Boott Mills, common (quar.),—,. 2 Jan. 3 IX Jan. 3 Nov. 21 IX Jan. 3 Holders of rec. Nov. 20a rtucyrus Co., preferred (quar. Pref. (extras (acct. accum. divs.), IX hX Jan. 2 Holders of rec. Dec. 20 Jan. 2 Jan. (quar.). Booth Mills, common Pref. (extra) (acct. accum. 3 Holders of rec. to Dec. 15a Jan. 2 Holders of rec. 2 Holders of rec. Dec. 20 2 Dec. 31 Holders of rec. Dec. IX Jan. 1 Holders of rec. Dec. 20a $1 Dec. 20 Holders of rec. Dec. 10a Holders of rec. Dec. 15 h3 diva.) Buffalo General Electric (quar.) California Petroleum .Corp., pref. ... (quar.) Calumet A Arizona Mining (quar.)..,.. Canada S. 8. Lines, pref. (quar.)...—. IX Jan. 2 IX Jan. 10 IX Canadian Car & Fdy., pref. (quar.)..... Canadian Consol. Rubber, pref. (quar.). Dec. 31 Dec. 20 15 Holders of rec. Dec, 2,7 Holders of rec. Dec. 22a Can. Crocker-Wheeler, com. A pf. (qu.). IX Dec. 31 Dec. Holders of rec. Dec. 20a Canadian General Elec.. 2 Jan. 1 Holders of rec. Dec. Holders of rec. Dec. 11a IX Jan. 1 Holders of rec. Dec. 20a 3 Holders of rec. Dec. 11a Canadian Woollens, common (quar.)... Preferred (quar.) IX Jan. 1 Holders of rec. Dec. 20a rec. II .25 Jan. 2 12 to Jan. 4 Jan. 1 Dec. 2 Holders of Dec. 9a $2.50 Jan. 3 Holders of ree. Dec. Holders of rec. Dec. 15a Jan. 1X 2 2 to Jan. rec. 2 13a 15* Dec. 18 Holders of 4 Jan. 10 Dec. 28 to Jan. 10 15* Jan. 3 Holders of rec. Dec. 10a 15* Jan. Nov. 30o rec. com. (quar.).. Carbo-Hydrogen of Amer., pref. (quar.) Case (J. I.) Threshing Machine— Preferred (quar.).. Case (J.I.) Plow Wks., 1st A 2d Celluloid Co. (quar.). Dec. la Holders of rec. Dec. 13a Jan. 3 Dec. 17 to Holders of Dec. 31 Dtc. 31 Jan. 15 ♦Holders of rec. Dec. Jan. 15 ♦Holders of IX Jan. rec. Dec. 17a 31 rec. Dec. 31 4 Holders of rec. Dec. 10a Central rec. Dec. 10 .11.50 Jan. 3 Holders of rec. Dec. 15a Holders of rec. Dec. 10 Holders of rec. Jan. 18a Central States Elec. Corp., pref. (quar.). Certaln-teed Products Corp., com. (qu.) Dec. 31 Feb. $1 Jan. 1 Holders of rec. Dec. 16a 50c. Jan. 13 Holders of rec. Dec. 23a First and second preferred (quar.) Chandler Motor Car (quar.) Jan. IX $2.50 Jan. 1 Holders of rec. Dec. Dec. 20a $1 Jan. IX 3 Holders of rec. Nov. 80a Dec. 30 Holders of Jan. 3 Holders of rec. Dec. Jan. 10 Nov. 30a rec. Dec. 21 to la 31 Dec. Leather, preferred (quar.)..... IX 3 Holders of rec. Dec. Jan. 3 Holders of rec. Dec. 17 3 Holders of rec. Dec. 30 Holders of rec. Dec. 14a Holders of rec. Dec. 14a 1 ♦Holders of rec. Dec. 23 Dec. 31 Holders of rec. Dec. 30a Dec. 16a *1X Common and preferred (monthly) Jan. 1 Holders of rec. Dec. 15 Dec. 30 Common (payable In common stock). Preferred B (monthly). 17 X El Paso Electric Co., preferred 3 20a City Invascng, common Clafllns, Inc. (quar.).. Jan. 10 Holders of rec. Dec. $4.50 Jan. 1 Holders of rec. Dec. la 15* Dec. 31 Holders of rec. Dec. 18a 3 Jan. ... Frankford A Southwark Pass, (quar.).i. Manila El. RR. A Ltg. (quar.) Second & Third 8ts.Paas.Ry.,Phlla.(qu.) Springfield Ry. & Light, pref. (quar.).. Twin City R. T., Minneapolis, common- 1 Holders of Dec. rec. la 15* Jan. 1 Holders of rec. Dec. 15a 3 Jan. 3 Holders of Dec. 14a 15* Jan. 3 Holders of rec. Dec. 14a $4.75 Jan. 1 Holders of rec. Dec. 15a $1.50 Jan. 1 Holders of rec. Dec. 10a Preferred (quar.) Union Passenger Ry., Philadelphia Union Traction, Philadelphia.... United Light A Rya., pref. (quar.). 15* Va. Ry <fe Power, pref. (pay. In pref stk.) West End St. Ry., Boston, preferred West Philadelphia Passenger Ry TO $2 $5 rec. Jan. 2 Holders of rec. Dec. 15a Jan. 20 Holders of rec. Dec. 31 a Jan. 3 Dec. 21 Jan. 1 Holders of rec. Dec. Jan. to 3 15a Banks. America, Bank of (guar.) 3 Jail. 3 Holders of rec. Dec. Chatham <fe Phenlx National (quar.) Commerce, National Bank of (quar.)... 4 Jan. 3 Dec. 3 Jan. 3 Holders of rec. Dec. 3 Jan. 3 Holders of Jan. d3 Extra ......... Cuba, Bank of, In New York—. Mechanics, Brooklyn (quar.) 6 18 18 Jan. to 2 Jan. 1 Holders of rec. fix Jan. 1 Holders of rec. X Jan. 1 Holders of rec. Dec. 15a 39c. Jan. 1 Holders of rec. Dec. 15 Dec. 9 Dec. Jan. 11 Jan. 3 9 to Jan. 11 Dec. 31 Dec. 22 to Jan. 1 Dec. 31 Dec. 21 to Jan. 11 Dec. Dec. 21 to Jan. 11 Dec. 31 31 Dec. 22 Dec. 31 Holders of rec. Dee. 15* Jan. Lawyers Title & Trust (quar.) Extra Holders of rec. to Dec. Dec. 15a Dec. 16 to Jan. 3 to Jan. 3 1 Jan. 3 Dec. 16 Jan. 3 Holders of 25 State".... 17 30 3 3 Manufacturers, Brooklyn (quar.) Jan. 3 Holders of rec. Dec. rec. Doc. d20 I8ai Miscellaneous. Advance-Rumely Co., pref. (quar.)..__ 15* Company, preferred (quar.) 15* Aeolian, Weber Piano A Pianola,pf.(qu.) 15* Air Reduction (quar.)__... $1 Allls-Chalmers Mfg., com. (quar.)..... 1 Preferred (quar.).. 15* Amalgamated Oil (quar.) ♦$1 .50 Amer. Agrlc. Chemical, com. (quar.) 02 Preferred (quar.) 15* Aeolian .... Bank Note, pref. (quar.) 75c Amer. Beet Sugar, pref. (quar.) Amer. Bosch Magneto Corp. 15* 3 Dec. 16 to Jan. 2 Dec, 20 Deo, 31 Holders of Dec. 31 Holders of rec. Dec. Jan. 15 Holders of rec. Feb. 15 Holders of rec. Jan, rec. Doc. Jan. 15 Jan. 15 ♦Holders of rec. Dec. Jan. 15 Jan. 15 Jan. 3 Holders of rec Dec. 31 20 31 24a Holders of rec. Dec. 24a Holders of roc. Dec. 31 2Ca Holders of roc. Dec. 20a Dec. 15a ....... Holders of rec. $2.50 Jan. (quar.) 3 Holders of rec. Dec. 15a Jan. 3 Holders of rec. Dec. 16a 15a 15* Dec. 11 a " (guar.)... (quar.).II.I...I" Amer. Exchange Secur. Corp. CI. A (qu.) .... American Hide A Leather, pref. (quar.). American Linseed, pref. 3 Jan. 1 Holders of rec. Dec. 15* Jan. 1 Holders of 15* (quar.)....... American Express (quar.) Jan. Jan 3 Holders of rec. Dec. 18 15* Jan. 3 Holders of rec. Dec. 15a 18a 2 $2 (auar.) ......III. pref. fquar.j American Radiator, oommon (quar.) Jan. 1 Holders of rec. Dec. 3 Holders of reo. Nov. 30a 15* 15* 15* 15* Jan. Jan. 3 Holders of rec. Dec. 11a 3 .Holders of rec. Dec. 15a Dec. 31 Holders of rec. Dec. 13o Dec. 31 Holders of rec. Dec. 13a 3 $1 Amer. Rolling Mill, oom. (in com. stock) American Rolling Mill, common 15a Jan. Jan. 15* (quar.)........ rec. Dec. Dec. 31 5 Feb. 1 Holders of rec. Dec. 10 Consolidated Cigar Corp.. com. (quar.). Consol. G. E. L, &P„ Bait.,com.(qu.) Continental Can, Inc., common (quar.). $1.75 Preferred (quar.) Common (special) Preferred (quar.) Preferred (quar.) Draper Corporation (quar.).. Drayton Mills, preferred (quar.) American Thermos BottleExtra (payable In Class B shares) American Thread, preferred American Tobacco, pref. (quar.). American Wholesale Corp., pref. (quar.) com. Preferred (quar.) American Woolen, com. (quar.).. Preferred (quar.) (qu.). 15* Fan. 1 Dec. 22 Jan. 2 Jan. 3 Holders of rec. Dec. la 35* Mar. xl Holders of rec. Feb. x 15a 2 Jan. Holders of rec. Dec. 112 16 20a 10a 15a Jan. to Jan. 2 Jan. 10a rec. 2 Feb. 1 Holders of Feb. 1 Holders of Jan. 1 Dec. Jan. 1 Holders of rec. Nov. 30a Jan. 1 Holders of rec. Nov. 30a Jan. 1 Holders of rec. Nov. 30a 1 Dec. 21 16 rec. rec. to Jan. 20a Jan. 20a Jan. 1 3 Holders of rec. Dec. 15a 1 Holders of rec. Dec* 11a Jan 1 Holders of rec. Dec. 11a com. $1.25 (quar.) IX ... Erie Lighting, pref. (quar.) Fairbanks Co., pref. (quar.) Famous Players-Lasky Corp., Dec. 31 Dec. 31 Deo. 20a rec. Dec. 24 rec. oi Dec. 15a reo. 2 Holders of Jan. 1 Holders of rec. Dec. 20a $2 Jan. 3 Holders ol rec. Dec. Jan. 3 Holders of rec. Dec. 20 IX IX Jan. rec Dec. 15 15a 10c Jan. 1 Holders of rec. Dec. 20 $1.50 Jan. 5 Holders of rec. Dec. Ian 1 *1X ' Jan 1 Holders of rec. Nov. 30a Dec. 2 31 10a X Jan. 1 Holders of rec. Dec. 15 TX Jan. 1 Holders of rec. Dec. 15 $1 .50 Jan. 1 Holders of __ General American Tank Car, com Second preferred (quar.) General Chemical, preferred rec. Dec. 15 a IX Jan. 1 Holders of rec. Dec. 15a IX Jan. 3 Holders of rec. Dec. 17a IX Jan. 3 Holders of rec. Dec. 24c 2 Jan. 15 Dec. Dec. 19 e2 Jan. 15 Dec. 9 to Dec. 19 Dec. 31 Dec. 16 to Jan. 2 (quar.). General Cigar. Inc.. deb. pref. (quar.).. General Electric (quar.) Extra (payable In stock) General Optical, common $2 , General Railway Signal, com. (quar.)... 9 to IX Jan. 1 Holders of rec. Dec. 20 IX Jan. 1 Holders of rec. Dec. 20 m *IX Jan. 1 dDec. Jan. 1 Preferred (quar.) Oodcbaux Sucar, pref (quar.) Gold A Stock Telegraph (quar.).. Goodrich (B. F.) Co., common (quar.) Preferred (quar.) Grasselli Chemical, com. $1 50 Feb.lSr 20 to Jan. •Holders of rec. Dec. Holders of rec. 1 31 Feb. 4x (quar) Great State Petroleum of Texas Great Western com. (quar.) Holders of rec. Dec. 2la Holders of rec. Dec. 15a Dec. 31 Holders of rec. Dec. Dec. 31 Holders of rec. Dec. 15a 3 . Dec. 31 IX (quar.) 8ugar, to ♦3 X Special Common (extra) Preferred (quar.) to 21 2 com.(qu ) Gaffney Manufacturing 15a 15 to 19 Ian. Holders of rec. Dec. Holders of rec. Dec. 15 19 Dec. Jan. 10a Jan. Dec. Holders of 3 . Holders of rec. Deo. Holders of rec. Dec. Jan. 25 50c. Jan. (qu.). Endlcott Johnson Co Preferred (quar.).. Preferred 15* 15* 1 Jan. Holders of 15a 1 Jan. Holders of Dec. 1 1 Jan. 1 rec. Jan. 2 3 Common (extra) Jan. Jan. rec. Jan. 10a 15* 4 to Jan. Dec. 3 Dec. 19 4 rec. 15* Holders of Dec. 2 Holders of Nov. 30 1 1 4 15a Dec. 21a 1 Jan. rec. Holders Holders of to Jan. Jan. Holders of 1 1 1 •Nov. 16 Holders of rec. Dec. 15 Jan. 3 2t 3 Jan. IX Jan. Jan. Jan. Eteenlohr (Otto) A Bros., pref. (quar.).. Elder Manufacturing, pref. (quar.) Electric Light A Power Co of Abington A Rockland Elec. Storaee Batt.. com. A pref. *125*c Jan. Jan. 15* to Dec. 1 aDec. 3* 21 rec. Jan. Jan. Dee. Holders of IX Holders of 15* 1 IX 15 2 15 Ian. 15 ^referred (guar) Edmund & Jones Corp., com. (quar.) Preferred (quar...... 75c. Jan. 15a Dec. 2X Holders of 15a rec. 2X (quar.) Holders of Dec. Holders of IX Common (extra). 3 Jan. 1 Dec. 31 IX 3 Hol lers of 15 Jan. to 8 Powd.,com.(qu) (quar.) Jan. Holders of rec. Dee. Dec. IX Eastern Rolling Mill, pref. (annual). Eastman Kodak, common Jan. 1 rec. IX 15* 31 Holders of IX 2 Dec. Dec. 22 Holders of rec. Dec. 1 IX (quar.).. Gas A Electrie Secur., com. (monthly) Common (payable in common stock) Dec. 31 1 1 IX Galena-Signal Oil, preferred (quar.). Jan. Jan. Jan. 2X du Poht de Nern. & Co., deb. stk. (qu.). m Pont (E. I.) de Nem. 14 30a Dec.* 24 IX (qu.) Dec. Dec. rec. Jan. 3 (Jam°8 H.) A Co., com. First preferred (quar.) 3 rec. Holders of rec. Dec. 24 *3X Dunham Jan. 10a Holders of 3 IX ... 31 10a 3 IX Dominion Iron A Steel, pref. (quar.) Dominion Steel Corp. com. (quar.).. Dominion Textile, common (quar.).... Preferred 10 Jan. Jan. IX (quar.) Second preferred Dec. 20 •Holders o/ rec. Dec. 15a IX Dominion Glass, oommon (quar.) Preferred Jan. 1 31 Dec. 24 15a 14 Dec. 20 Dec. 31a Dec. rec. 10 Dec. rec. Dec. 3 rec. Dec. rec. Holders of Dec. 15 ♦Holders of ree. Dec. 22 rec. Holders of 1 Dec. 15 ♦Holders of rec. Dec. Dec. Holders of 3 rec. Farrell (Wra.) A Son. pref. (quar.) 22 Dec. 20 Jan. Jan. rec. Federal Oil, preferred (quar.)... Firestone Tire & Rubber, com. (quar.).. to 10a 10a rec. Jan. (quar.) Amer. Sugar Refg., oom. A pref. (quar.) American Sumatra Tobacco, preferred.. American Telephone A Telegraph Dec. Holders of 15 rec. 15a rec. Holders of 15a to Dec. Holders of Holders of 31 Dec. 22 rec. 1 Jan. 15* Holders of 1 Jan. $4 3 15 ♦15* 15* 15* $1 15a Jan. Jan. ♦15* American Stores, common (quar.) First and second preferred Dec. IX Jan. 31 IIIIIIIII Dec. 20 rec. X 15 ♦Holders of rec. Dec. Amer. Steel Foundries, com. (quar.) II11 Common (payable In common stock) Preferred (quar.) Dec. 20a rec. 2 Dec. to rec. Holders of Extra Deo. Dec. Holders of Dictograph Products Corp., pref. (qu.). 2 Dixon (Joseph) Crucible (stk. dlv.).._. ♦el 50 Dodge Manufacturing, com. (quar.)... IX Holders of rec. to 3a Holders of IX ♦25c. Jan. II Jan. 1 4 ..... (quar.).I rec. Dec. 31 2 31 Smelters' Securities, pref. A (qu.) Preferred B (quar.) Amer. Snuff, com. (quar.)I——Ill- Jan. Holders of Holders of rec. Dec. 15a Holders of rec. Dec. 20a 75c. Dec. 31 Dayton Power & Light, common Preferred (quar.)..... 15 ♦Holders of rec. Dec. Seven per cent preferred (quar.) 1 Dellcn Tire A Rubber, pref. (quar.) Detroit & Cleveland Nav. (quar.) ♦50c. Jan. Amer. 3 IX (quar.) (quar.). Common (extra).. 15 Jan. Jan. IX ... Crowell A Thurlow SS. (quar.) Crucible Steel, pref. (quar.). Cuba Cane Sugar Corp., pref. (quar.)... Holders of reo. Jan. 2 IX . 10a 24a Dec. Jan. Dec. Jan. Nov. 10a 18 5 $1 rec. 18 5 10a Computlng-Tabulating-Recording (qu.). Holders of rec. Dec. Holders of rec. Dec. rec. Dec. 25* 1 Holders of Holders of I Jan. (quar.) Holders of Holders of rec. Dec.d26 ....... Italian discount <fe Trust IX Preferred 3 Trust Companies. Guaranty (quar.) Hudson (quar.). Holders of rec. Dec. Holders of rec. Dec. 10a 1 Jan. Dec. 24 Holders of rec. Dec. 31 Holders of 1 Jan. IX Jan. 3 20 Dec. 22 1 25c. Jan. (0) IX 3 5 Extra rec. 10 2 5 Yorkville (quar.) Deo. 20a Davis Mills Jan. to rec. 17a Jan. 3 Holders of 1 3 3 i 2 Jan. 3 Extra Union Exchange National Jan. 1 2 rec. Cluett, Peabody & Co., Inc., pref. (qu.) ColumbiaGraphophone Mfg., com. (qu.) Common (payable In common stock).. Dec. Cuban-Ameiican Sugar, com. (quar.)... Preferred (quar.) 2 ......... ♦6 Holders of rec. Jan. IX ... 15a Dec. 20 5 Clifton Manufacturing Dec. 17a Dec. rec. Jan. Cities Service— Cities Service, Bankers' shares (mthly.). Holders of rec. Nov. 30a 10 16a Dec. 30 2 Jan. Holders of IX Chicago Telephone (quar.).. 15a 15* 3 3X Cbesebrough Mfg., common (quar.) Preferred (quar.) Chicago Mill ALumber, pref. (quar.)... Holders of rec. Dec. GlassMach., Holders of J *1X 3 (quar.) Dec. 31 IX — Jan. com. 15 Jan. 2 1 Preferred Dec. 31 *1X Duluth-Superlor Tract., pref. (quar.)... American Can, pref. (quar.) Amer, Car <fc Fdy., com. to IX pf.(qu.) $3 Extra.... North Side, Brooklyn 21 IX Central Coal A Coke, com. (quar.) Preferred (quar.) Brazilian Tr„ L. & Pow., prof. (guar.).. Continental Pass. Ry., Philadelphia.... Amer. Window Jan. Dec. Southern Ry., preferred 2X Union Pacific, common (quar.) 25* United N. J. RR <fc Canal Cos. (quar.). 2X Street and Electric Railways. Boston Elevated, common (quar.) I137H Preferred 35* Preferred to 3 Second preferred (quar.) Southern Pacific Co. (quar.) Six per cent preferred 10a 16 2 12 12 A Jan. littsb. McKee«p. A Yougbloghony Reading Company, common (quar.) (quar.) Amer. Public Service, Dec. Dec. 10a Dec. 3 Plttsb. Ft. Wayne A Chic., com. (quar.) Preferred (quar.) Locomotive, 3 Jan. ... American Jan. Dec. 27 rec. Jan. Norfolk <fe Western, common (quar.).. Northern Securities American Cigar, pref. rec. IX New York A Harlem, com. and pref New York Lackawanna A West. (quar.). Preferred (quar.) American Chicle, pref. Holders of 1 2 Lehigh Valley, com. (quar.)... Preferred (quar. I Amer. 31 87>*c Jan. Joliet & Chicago (quar.) United Dec. 5 ... I. 88. Lines, com Auto Sales Corp., pref Preferred Holders of Holders of rec. Dec. 31 IX IX (quar.) (quar.) Beaver Board Cos., Jan. 10c Atlantic Terra 4X Armour A Co., pref. (quar.) Armour Leather, pref. (quar.) Railroads (Steam). Alabama Great Southern, ordinary— Days Inclusive. 20C 3J* Arkansas Natural Gas. com. (quar.) Common (extra) Per Books Closed. Payable (Continued) Apsley Rubber, preferred Jfame 0/Company. When Per Name of Company. include dividends Jan. 31 Holders of reo. Dec. 31 Jan. 3 Holders of rec. Dec. 15a Jan. 3 Holders of rec. Dec. 15a Jan. 3 Holders of rec. Dec. 15a IX IX X Jan. IX 10 IX lx 15a Dec. 18 1920.] CHRONICLE THE Per Name of When Books Closed. Cent. Company, Payable. Days Inclusive. Per Tap A Dye, common (quar.). (quar.) (No. 1)....... 1 Holders of rec. Dec. 16 2 Jan. 1 1 Holders of rec. Dec. 15 Six per oent pref. (quar.).. IX Jan. 1 Holders of reo. Deo. 16 3 Holders of rec. Dec. 18a 5X% pref. (quar.) IX Jan. 1 Holders of reo. Deo. 15 3 Deo. 31a rec. Dec. 20 Quaker Oats, common (quar.) Common and Class B Common (quar.) Jan. 1 Holders of 37Xc Jan. 1 IX 1X Jan. 20 Holders of 31 Holders of rec. Dec. 20a $1 Dec. rec. Jan. Jan. 3 Holders of rec. Dec. Holders of rec. Dec. 15a Jan. 3 Holders of rec. Dec. 13a 4 Jan. 3 Holders of rec. Dec. 13a 1X Jan. 3 Holders of rec. Dec. 13a IX Jan. 3 Holders of rec. Dec. 20a 16 to Dec. Dec. 24 2 Dec. 24 Dec. 16 to Jan. 3 Dec. 25 tc Jan. Jan. 3 Dec. 25 to Jan. to Jan. 3 Dec. 25 Jan. 2 Holders of rec. Dec. 1 Holders of rec. Dec. Dec. 31 Holders of rec. Dec. 10a IX Dec. 31 Holders of rec. Dec. 10a First 2 Illinois Pipe Line Imperial Oil, Ltd.— Jan. 1 Holders of rec. Dec. 15a Cum. Dec. 31 10 Dec. 1 to (3 ,481,0 90,828,0 137,442,0 87.943,0 243,990,0 3,316,749,0 916,0 646,0 Items and other de¬ ductions from gross deposits.. 5% 424,658,0 132,622,0 231,802,0 1,086,238,0 212,733,0 261,957,0 129.082,0 156,144,0 539,118,0 139,472,0 2,551,0 1,586,0 1,421,0 4,211,0 681,0 625,0 2,345,0 891,0 premises Uncollected 78,622,0 1,554,0 231,0 17,658,0 53,408,0 43.513,0 43,496,0 666,505,0 11,387,0 8,332,0 ' 48,635,0 126,827,0 56,372,0 63,433,0 58,196,0 27,749,0 1,072,0 936,0 2,665,0 1,546,0 1,300,0 938,0 1,140,0 787,0 451,0 377.0 83,354,0 38,859,0 476,0 949,0 623,0 544,0 916,0 586,0 665,0 207,0 1,023,0 498,0 231,0 306,0 916,0 567,0 22,663,0 against Federal Reserve bank notes.. All other resources Total resources.. 489,516,0 1,819.523,0 434,162,0 605,778,0 281,170,0 271,933,0 937,177,0 261,296,0 166,476,0 268,267,0 183,293,0 464,447,0 6,233,038,0 LIABILITIES. 7,718,0 12,351,0 Capital paid In Surplus Government deposits 1,137,0 Due to members, reserve account 115,328,0 Deferred availability Items — Oth. deposits, lncl. for. Govt. cred. Total gross deposits F. R. notes in actual circulation. 37,443,0 521,0 154,429,0 289,134,0 26,185,0 8,493,0 10,352,0 51,308.0 13,069,0 13,712,0 8,981,0 1,482,0 1,709,0 683.805,0 109,089,0 147.637,0 86,177,0 46,298,0 52,484,0 409,0 15,001,0 1,279,0 5,285,0 4,023,0 13,901,0 8,067,0 7,050,0 1.312,0 23,917,0 2,150,0 59,428,0 43,598.0 240,0 4,364,0 5,884,0 1,880,0 3,398,0 5,178,0 47,674,0 239.815,0 "64,075,0 21,427,0 58,561,0 36,347,0 226,0 1,700,0 669,0 44,723,0 19,663,0 1,702,0 793,964,0 158,148,0 202,239,0 105,416,0 70,639.0 301,778,0 102,971,0 863,560,0 276,146,0 349,311,0 147,500,0 171,693.0 541,967,0 134,279,0 4,460,0 8,395,0 2,478,0 4,091,0 6,904,0 99,174,0 46,707,0 465,0 11,662,0 164,745,0 28,394,0 1,599,0 2,759,0 49,176,0 120.316,0 1,758,967.0 516,934,0 32,823,0 35,406,0 242,0 3,476,0 24,511,0 65,874,0 127,551,0 81,404,0 108,856,0 83,840,0 161,957,0 2,328,806,0 81,181,0 266,811,0 3,311,842,0 1,205,0 283,0 77,901,0 4,152,0 V. R. bank notes in circulation— Net liability AU other liabilities Total liabilities 19,430,0 36,040,0 6,454,0 48,466,0 22,506,0 5,800,0 22,675,0 11,574,0 7,489,0 3,328,0 14,580.0 3.948,0 7,327,0 10,290,0 2,702,0 6,823,0 113,948,0 489,516,0 1,819,523,0 484,162,0 605,778,0 281,170.0 271.933,0 937,177,0 261,296,0 166,476,0 268,267,0 183,293,0 464,447,0 61,233,038 37,967,0 10,106,0 17,647,0 3,692,0 7,628,0 2,994,0 14,400,0 4,605,0 214,523,0 Dec. Two dphers (00) omitted. Boston. $ Cleveland. Richmond Phlla. New York. LIABILITIES (Concluded.)— Batlo ef total reserves to net de¬ $ :;y Atlanta. Chicago. $ $ $ $ $ 2405 CHRONICLE THE 181920.] Dallas. $ /; $ San Fran. Total. $ 5!/. Louis. Minneap. Kan.City. $ $ $ * posit and F. R. note liabilities endors as 47.1 40.4 9,831,0 35,912,0 784,0 576,0 56.7 56.1 39.1 51.8 combined, per cent Memoranda—Contingent liability 44.5 45.6 41.4 41.1 40.1 15,166,0 40.8 28,265,0 29,808,0 432,0 768,0 416,0 40.8 er on: Discounted paper rediscounted with other F. R. banks 6,400,0 125,382,0 Bankers' acceptances sold to other 7,923,0 7,923.0 F. R. banks without endors't.. Contingent liab. on bills purch. foreign correspondents (а)Includes bills discounted for 1,168,0 other F. R. banks, via (б) Includes bankers' acceptances 17,796,0 bought fr for 1,280,0 om Collateral security for Federal Reserve notes Gold and gold certificates Gold redemption fund - - outstanding: Cleve. $ $ Richm'd Atlanta % Board 172,247 13,880 required 'Excess amount held — Liabilities— amounts returned for destruction 17,620 121,320 640,839 155,898 10,290 6,130 83,509 114,770 7,560 13,052 1,176 "3",283 11,200 36,360 75,127 449,355 108,015 13,443 35,653 58,081 15,453 Total. $ t 4,292 36,031 "~8, 340 183,144 Net amount of Federal Reserve notes received from 419,272 1,166,294 325,582 397,612 180,232 239,267 237,200 130,494 162,174 51,938 62,507 133,385 979,893 170,836 215,833 114,139 139,845 186,127 Comptroller of the Currency Collateral received from Federal Reserve (Gold -- bank:\Eligible paper Total ... 40,526 S 303",776 3,677,562 606,244 15,280 86,115 267,426 5,331 116,821 5,230 i~7~, 474 826,316 15,234 85,158 60,320 201,144 2,466,999 431,605 15,344 19,470 - „ 93,799 120,900 101,395 303,776 4,283,806 25,795 102,632 1,210,563 25,428 39,643 73,534 115,653 75,664 220,614 2,898,604 305,632 1,002,794 287,902 365,712 154,083 176,532 6,583 4,839 16,401 11,756 139,234 16,498 Federal Reserve notes held by banks. 640,839 155,898 21,619 98,872 83,509 114,770 5,914 86,115 303,776 3,677,562 365,720 4,934 36,965 863,560 276.146 349,311 147,500 171,693 541,967 134,279 81,404 108,856 81,181 266,811 3,311,842 289.134 Federal Reserve notes In actual circulation. Member Banks of the Federal Reserve ITEMS OP REPORTING MEMBER BANKS IN FEDERAL RESERVB OTHER REPORTING BANKS AS AT CLOSE OP BUSINESS DECEMBER 3 1920. cates and of 24 millions in other loans and investments, are shown liquidation of all classes of loans accompanied by large reductions and other demand deposits, and a continued increase In shows an 13.3% of the banks' total loans and investments. For the New York City banks an increase of accommodation at the local Reserve Bank from 803 to 865 millions is shown, resulting In an Increase of the ratio of accom¬ modation from 14.5 to 15.7%. v Government deposits show a reduction of 70 millions, other demand deposits (net) declined by 55 millions, while time deposits increased by 11 millions. The New York City banks report decreases for all classes of deposits as follows: Government deposits, 29 millions; other demand deposits, 43 millions, and time deposits, 5 millions. ' In keeping with the increase in accommodation at the Federal Reserve banks, reserve balances of the reporting institutions went up 45 millions, the New York banks showing an increase in this item of 30 millions. Gash in vault shows a^total reduction of 12 millions, nearly half of it in New York City. to 823 member banks in leading cities. Holdings of Liberty bonds and Victory notes show but nominal changes those of Treasury certificates declined by 37 millions, the Dec. 3 low record for the year. Loans supported by Government war securities declined by 5 millions, loans sup¬ ported by corporate securiites—also by 5 millions, while other loans and investments, composed largely of commercial loans and discounts, show a reduction for the week of 56 millions. As a consequence, total loans and Investments of reporting institutions were 102 millions less than the week before. For the member banks in New York City increases of 3 millions in U. S. bonds and Victory notes of 2 millions in loans secured, by Govern¬ ment obligations and of 11 millions in loans supported by corporate securi¬ ties, as against reductions of 25 millions in the holdings of Treasury certifi¬ while holdings of 276 millions constituting a member banks In each Federal Reserve District at close Cleveland. Richm'd. Phila. New York of all reporting banks at the Federal Reserve banks Increase for the week from 2,174 to 2,210 millions, or from 13.0 Accommodation borrowings from the Federal Reserve banks are indicated In the Federal Reserve Board's consolidated weekly statement of condition on Dec. 3 of Boston. reducing the total loans and Investments of these banks by 33 millions. Government Federal Reserve District. Definitions of the different items liabilities of the Member Banks. 14 1917, published in the "Chronicle" Dec. 29 1917, page 2523. STATEMENT SHOWING* PRINCIPAL RESOURCE AND LIABILITY BANK AND BRANCH CITIES AND ALL 2,105 System.—Following is the weekly statement issued by the Federal Reserve Board giving the principal items of the resources and in the statement were given in the statement of Deo. Data for all reporting 762,159 173,518 191,484 47,883 485,008 121,458 738,784 2,383,387 626,912 775,619 346,309 441,619 1,438,651 342,859 192,761 276,196 202,854 627,022 8,392,973 Fideral Reserve notes outstanding.._ ♦ $ 742,900 2,371,640 680,580 703,520 398,060 412,840 1,259,900 392,800 188,120 264,580 196,160 549,440 8,160,540 94,321 143,680 94,765 245,664 3,876,734 497,741 219,282 323,628 1,205,346 354,998 305,908 217,828 173,573 Federal Reserve notes received from Comptroller, gross Further 7,923,0 6,917,0 738,784 2,383,387 626,912 775,619 346,309 441,619 1,438,651 342,859 192,761 276,196 202,854 627,022 8,392,973 Total In , Dallas. San Fr. K.City. $ i>:« $ 22,775 3,500 3,207 16", 105 19,399 ~~2~, 938 15,000 114,389 120,000 49,000 55,800 765,594 157,408 203,538 102,145 114,025 12,295 11,994 25,820 13,428 214,299 105,000 Minn. St.L. Chicago. % 209,608 12,592 5,600 22,785 - Gold settlement fund—Federal Reserve "■ l;' • 163,500 37,680 31,900 26,149 62,735 113,640 305,632 1,002,794 287,902 365,712 154,083 176,532 Federal Reserve notes outstanding Lisa Phila. $ % « AGENTS* ACCOUNTS AT CLOSE OF BUSINESS DEC. 10 1920. Boston. New York hand Eligible paper:/Amount • FEDERAL RESERVE (In Thousands of Dollars). on 125,382,0 . , STATEMENT OF 16,201.0 736,0 88,920,0 1,006,0 Federal Reserve Agent at— Resources— 752,0 1,004,0 other F. R. banks: Without their endorsement Federal Reserve notes 1,312,0 18,666,0 6,073,0 Three ciphers (000) omitted. of business December 3 1920. Dallas. St. Louis. Minneap. Kan. City Chicago. Atlanta. San Fran. 93 80 46 108 35 38 83 51 Total. 68 48 114 $12,610 $46,729 $11,347 $42,464 $29,008 $16,222 $7,571 $32,648 $269,101 30,460 61,873 33,916 53,691 13,810 9,942 22,650 63,145 613.933 85,999 9,637 20,158 6,775 36,454 2,723 1,020 $14,751 23,206 5,388 $19,573 252,879 $14,630 27,986 3,949 $21,548 20,375 5,866 3,174 15,136 196,279 14,975 127,310 15,452 13,882 7,175 6,771 47,176 3,652 1.683 6,828 5,431 25,810 276,145 53,826 512,917 66,896 138,377 76.874 53,336 158.869 36,407 20,216 50,173 50,828 136,739 1,355,458 427,243 47,037 193,980 1,283,742 10.318 34,091 900,878 202,294 328,906 111,460 799,918 3,991,070 Number of reporting banks 59 572,847 977,886 387,776 916,242 1,514,220 67,211 99,715 605,104 557.449 2.439,458 178,695 28,246 20.580 37.279 17,970 675,626 939,869 39,360 389,371 332,729 108,317 229 1,832 79,243 — U. 8. bonds to secure circulation Other U. S. bonds, incl. Liberty bonds.. U. 8. Victory notes U. 8. certificates of indebtedness ... e Total U. 8. securities... Including bills re¬ L fans and investments, discounted with Federal Reserve Bank: | Loans sec. by U. S. war obligations. Loans sec. by stocks and bonds All other loans and Investments 69,051 74,205 30,886 Total loans and investments, including 1,094,761 6,214,972 635,798 78,398 27,011 125,817 775,521 4,836,695 444,210 158,630 rediscounts with F. R. banks Riserve balances with F. R. Bank Cash In vault Net demand deposits— Time deposits 35,099 100,359 32,034 16,461 30,199 61,943 439,652 128,045 411,284 1,740,578 28,994 384,362 34,514 292,733 506,752 580,848 363,924 666,124 41,376 18,519 45,629 9,345 8,243 13,963 303,560 192,796 70,695 394,868 99,645 215,975 131,165 698 280 218 157 1,115 17,503 22,747 5,911 20,171 17,741 29,640 623,018 315 2,455 8,795 60,158 2,685 8,394 2,162 5,657 253,911 72.055 25.959 79,463 1,330,455 13,113 65,689 240,275 1,301.712 643,865 150.539 1,346 7.604 1,151 2,479 394 29.568 283,427 46,977 24,090 30,841 32,662 1,105 Secured by U. 8. war Bank: obligations—— 10,662 17,004 71,718 255,651 36 All other. Bills rediscounted with F. R. Bank: obligations " All other 2. 18,018 131,154 37,370 7,925 77,137 Secured by U. 8. war 1 200 4,085 39,817 Government deposits Bills payable with F. R. 1 519,855 28,460 42.280 Data of reporting member banks in Federal Reserve Bank and branch All F. City of Chicago. New York City. R.JSank Cities. Thru ciphers (000) omitted. Dec. 3. Nov. 26 Dec. 3. Nov. 26. Dec. 3. 287 Nov. 26 « Dec.'6. Nov. 26. 287 208 208 Dec. 3. Nov. 26 Dec. 3 '20. Nov. 26 '20 Dec. 5 '19 329 823 824 796 $100,380 $101,010 $269,101 $269,707 $269,425 613.933 614,453 631,374 256,465 328 72 51 51 $37,862 $1,439 $1,439 $96,335 $96,335 $72,386 $72,362 219,653 Other U. 8. bonds, incl. Lib. bonds. 627,852 10,837,478 528,665 2.822,479 Total. AllOther Refort. Bks. 72 U. 8. bonds to secure circulatiop 58,017 cities and all other reporting banks. F. R. Branch Cities 537,862 Number of reporting banks 355,900 1,321,183 16,630,185 79,952 1,332,081 23,443 376,887 25,811 11,066 25 774 57,902 148,036 3,050,082 38,510 256,244 1.002,317 11,323,767 79,000 218,358 17,687 17,707 340.752 342,696 151,555 151,050 121,626 120,707 76,401 74,806 12,110 12,039 108,945 106,994 53,746 52,930 196.279 194.081 137,221 16,165 18,059 173,366 204.495 62,927 66,011 33,588 39,852 34,157 112,368 42,673 276,145 313,179 862,017 446,284 468,247 47,401 49,244 719,398 750,520 340,614 342,353 295,446 298,547 1,355,458 1,391,420 2,019,281 obligat'ns. 399,572 397,678 bonds.. 1,134,2911,123,224 investments__:3,515,362 3,539,739 69,244 Loans sec. by stocks and 327,911 334,531 .037,274 900.878 905,677 95,357 97,353 137,248 134.668 671,076 409,373 3,050,082 3,054,789 408,996 489,664 492,187 7,251,324 2,258,499 2,262,258 1,858,996 1,866,544 11,323,767 11,380,126 3,204,845 ,021,271 670,853 2,148.899 7,206,272 2,155,752 All other loans and (J. 8. Victory notes U. 8. certificates of Indebtedness... Total U. 8. securities Loans and investments, incl. bills re discounted with F. R. Bank: 69,927 Loans sec. by U. S. war Total loans and investments, incl.j5 ,495,509 5,528,888 redlscounts with F. R. Bank... Reserve balance with F. R. Cash In vault 128,464 116,409 37,716 ,356,109 4,399.615 905,160 310,181 300,899 110,402 * Net demand deposits 305,116 Time deposits deposits. Government ,466,510 561,804 591.941 Bank... Bills payable with 7,270 36.526 1,016 248,621 . 265,205 22,687 16,630,185 16,732,012 16,178,518 ,490,293 10,745,422 10.828,672 3,225,9683,231,523 2,658,795 2,671,817 1,206,946 1,406,193 152,939 1.332,081 154,660 192,937 199,406 941,070 127,106 978,015 395,987 388,105 375,887 87,158 85,920 72,479 73,962j 226,985 217,488 39,109 10,837,478110,892,122 11,203.994 909,917 7,565.313 7,621,141 1,719,534 1,707.165 1,552,631 1,563,816 611.790 610,199 2,822,479 2,811,123 2,270.678 910.516 916,077 298,592 1,294,612 1,290,408 415,063 17.503 87,799 6,196 1,192 15,120 3,157 13.154 66,483 5,382 F. R. Bank: Secured by U. 8. war 25.382 396.243 418,494 All other Bank: obligations. All other 151,590 86,240 89,686 623,018 659,770 1,109 1.010 960 2,455 2,069 4,942 208,649 918,156 29,494 31,980 13,880 13,511 253.911 254.140 320,170 183.195 210,537 986,400 178,940 177,368 165,115 162,523 1,330,455 1,258,047 419,428 7.9 12.0 12.2 12.5 12.6 10.9 11.0 11.9 12.1 19.1 128.353 129,322 9,357 9,694 487,805 Secured by U. 8. war 980,186 140,535 1,445 obligations. Bills rediscounted with F. R. 1,348,277 9,606,115 408,739 170.670 14.7 15.0 7.9 Rati* »f U. 8. war securities and war paper to total loans and invest¬ rediscounts with ments, Including Federal a Reserve Bank, per cent.. Exclusive of rediscounts with Federal Reserve banks. THE 2406 CHRONICLE Wall Railroad and Street, Friday Night, Miscellaneous pec. 17 1920. Stocks.—The week's Monday when the transactions totaled nearly 1,400,000 included such and shares well known issues as American Locomotive, Am. Sugar Refining, Baldwin Locomotive, Beth. Steel, U. S. Steel, Republic Iron & Slteel, Cruc. Steel and few of the oil and motor stocks. It is interesting to note, however, that the railway list was scarcely touched by this movement—St. Paul and Mo. Pac. only being repre¬ a Railroad Bonds.—No sales of State reported at the Board this week. The market for railway and industrial bonds has again been unusually active and operations at the Exchange have included a large number of issues. It has behaved itself somewhat better than last week, however, in that not all the bonds different exceptions traded in have declined. Among the Reading and Atchison 4s, Bait. & Ohio 43^s, are St. Louis & S. F. Series A and all of which these few a some of the lower level. United Bonds.—Sales of States Government bonds the Board include only the various The following sales have occurred this week of shares not represented in our detailed list on the pages which follow: Daily Record of Liberty Loan Prices. Dec. 11 Dec. 13 Dec. First Sales j STOCKS. for Range since Jan. 1, Lowest. Total sales in Range for Week.. High est. Highest. $ per share, j $ per share $ per share. 87 Allegheny & Western 100 500 Dec 15 Dec 87 200 87 Dec 15 43% Dec 14 87 American Bank Note. 50 44 Dec 13 39 Feb 48% Am Brake Sh&F.no par 300 47% Dec 16 48 Dec 15 44 Dec 60 American Radiator...25 1,000 66% Dec 16 81% Dec 17 67% Dec 14 94 Dec 11 66% 81% Dec 73 Nov American Snuff Am Wholesale Ann 100 700 pref_-100 100 20 90 Dec 14 90 Dec 14 89% 100 25 Dec 14 25 Dec 14 20 May 2 2% Dec 151 Dec 151020 Dec III 950 Aug Arbor pref. Assets Realization 10 Atlantic Refilling 100 Preferred Atlas Tack 100 Corp..no par Auftln.Nlcbols&Conopar Preferred 2% Dec 17 1,900 90 950 400 102 % Dec 13 103 % Dec 11 102% 500 17% Dec 15 18 Dec 11 17% 2,300 10% Dec 17 12 Dec 11 10% 64% Dec 14 66% Dec 13 100 200 Sales 50 1,400 Preferred 60 200 Barnet Leather...no par Barnsdall class A 25 700 800 300 36 Auto Class B...........25 Barrett Co (The)....100 Dec 115% Aug 95 34 6% Dec 1570 Dec 114 82 June Dec 14 23% Dec 16 Dec 93 Jan Dec 15 36 Dec 11 33 Nov Dec 16 36 Dec 16 35 June Mar Dec 82 Dec 100 Brunswick Terminal. 100 Buffalo Roch& Pitts. 100 1,800 3% Dec 13 4% Dec 13 3% Dec 8% Jan Mar 65 Dec 14 65 Dec 11 50 Calumet & Arizona... 10 Canada Southern 100 1,300 42 Dec 16 43 Dec 15 42 600 Mprref.. 100 300 Jan 240 Nov 40 Doc 16 40% Dec 16 38 80% Dec 16 81 Dec 17 80% 1,600185 Dec 13 192% Dec 16 175 .200 100 500 Cluott, Peabody & Co 100 Preferred 100 1,500 Computing-Tab-Rec. 100 Davison Chemical no par De Beers Cons M.no par Eastman Kodak 100 Elk Horn Coal pref...50 Chem Cons ctfs dep.. Gen Chem pref...100 69 Jan 62 Jan Feb 17 Oct 45% Dec 106 Jan 100 85 Dec 16 85 Dec 16 85 Dec 104 Jan 600 34% Dec 14 25% Dec 16 35 Dec 13 34% Dec 56 Dec 13 25% Dec 40 Sept Dec 11 15 15 Dec 14 17 Dec Dec 16 510 Dec 535 Aug Dec 16 35 Dec 16 z.32% Dec 45 Mar 5% 97% 32% 71 Dec 13 Dec 29 Dec 16 6% Dec 17 98% Dec 13 Dec 14 43 Dec 14 78 3,000 100117 Dec 14 117 5% Dec 15 97% 32% Dec 15 71 Dec- 95 Dec 16 50 4 Dec 14 Dec Mar Dec 134% Dec 100 Nov 100 Nov Dec Dec 16 95 4% 95 Dec 15 50 Dec 13 45 1.9% Dec 13 20 Dec 13 19 Dec 100 15% Dec 15 15% Dec 15 15 'Nov 20 500 78 Dec 14 82 Dec 13 78 Dec 88 100 00 Dec 14 60 Dec 14 57 200 70 Dec 13 70 Dec 13 70 Preferred ..100 Manhattan Shirt Marlln-Rock Martin v Oct 71 33% Nov 60% (Nov 118 Dec Jan Jan Nov Dec Jan Sept Aug Feb Dec Jan 200 73 Dec 11 73 Dec 11 73 Nov 91 Apr 700 40 Dec 13 40% Dec 11 40 Dec 95 Apr 97% Dec 13 97% Dec 13 100 93 Sept 102% July 155% Sept 100 700 131 Dec 11 131 Dec 11 129% 200 95 Dec 15 95 Dec 15 93% 500 200 10 Dec 17 11 Dec 11 10 Dec 45 52% Dec 15 53 Dec 16 49% Nov 80% Feb Apr Jan Mar Apr 25 300 16 Dec 13 17% Dec 16 16 Nov 33% Jan t c.no par 700 12 Dec 13 16 12 Dec 63 Feb 12% Dec 30% Jan 18 Dec 33 Parry no par Mathieson Alkali 1,700 12% Dec 16 50 300 100 1,600 preferred 100 Ctfs dep stpd asstd. 800 4 800 3% Dec 11 Maxwell Dec 78 3 95 Jan Mar Dec 192 Doe 14 117 500 117% Dec 13 1225* Dec 17 117% 100 84% Dec 17 84% Dec 17 84% 100 88 Dec 14 88 88 Dec 14 3% Dec 14 Feb 108% Dec 43 200 Loose-Wiles 1st pref. 100 MalPson (HR)AConopar Motor First 18 Dec 13 2% Dec 15 Dec 14 Second pref erred.. 100 200 Ctfs dep stpd asstd. MStP&SSM leased 100 600 100 55 Mulllns Body. no par Nashv Chatt & St L. 100 Nat Anil & Chem.no par National Biscuit.... 300 20% Dec 13 100] 1,000 Preferred 100 Norfolk Southern ...100 Norfolk & West pref. 100 Ohio Body A Blow no par OtDSteelpref 100 Pacific Mall SS___ Pacific Oil wi 5 Dec 16 5 Nov 38 Dec 3% Dec 3% Dec 14 2% Dec % Dec ^0% Feb 60 Dec 51 1 55 Dec 2% 4 3% Dec 13 Dec 16 Dec 1 16 13% Dec 11 18% Dec 11 2% Dec 13 H Dec 15 45% Dec 14 Dec 13 Dec 16 Dec 16 21% Dec 13 105 Dec 20% 14 100 45% Dec 14 99 % Dec 13 103 50 Dec 14 63% 8 Aug 111% 44 Feb 97 Dec 125 86% 610 106% Dec 14 108 Dec 14 103% July 116 200 13 Dec 13 10 13% Dec 17 Feb 29 200 66 Dec 11 66 Dec 11 64 May 72 1,000 10 Dec 13 10 Dec 15 10 Dec 29% 100 76 Dec 14 76 Dec 14 76 Dec 82 800 15% Dec 16 15%. Dec 13 15% Dec 38% 7,000 Parish A Bingham no par Penney (J C) pref...100 3 100 105 100 3,200 July Apr Jan Nov Jan Dec Jan Jan Jan Jan Mar Jan June Nov Jan 37% Dec 14 12% Dec 17 38 % Dec 17 37% Dec 39% Dec 14% Dec 11 12% Dec 47% Jan 86 98 86 Dec 14 86 Apr 400 10 Dec 13 10% Dec 14 9 June 700 30 Dec 13 30% Dec 11 30 Dec 68 Mar 100 100 70 Dec 14 70 Dec 14 70 Dec Mar Rand Mines Ltd.no par Reis (Robt) A Co.no par 92% 1,800 21% Dec 13 20 Nov 29 June First preferred 100 100 21 Dec 16 200 7 Dec 14 1,400 65 Dec 16 8 Dec Dec 14 no par 1,700 19% Dec 15 Tex Pacific Land Tr. 100 100 210 Third 900 Avenue Ry___100 Tidewater Oil 100 Rights.. Twin CRT pref 7,700 100 United Cig Stores pf.100 United Drug Un Dyewood WeberAHeilbroner White Oil Wilson A Co pref 100 100 13 10 189 100 Dec 11 7 Dec 23 65 Dec 84 Dec 14 Dec 13 210 14% Dec 15 Dec 15 189 19% 9% Dec 15 190 Dec 11 14% Dec 15 10 77% Dec 16 771% Dec 16 77% 99% 10 700 99% Dec 14 100 Dec 16 98 1,200 x94 100 z48 Dec 15 z48 no par 1,000 24,500 7% Dec 15 14% Dec 17 100 100 79% Dec 15 no par 30 13 210 Dec 14 18% 66% Dec 14 Sears, Roebuck, pref. 100 450 100% Dec 16 102% Dec 13 100% Seneca Copper...no par 4,200 16% Dec 17 17% Dec 11 14% Shattuck Arizona 10 1,700 5% Dec 14 5 5% Dec 14 Southern Pacific rights.. 106,290 22% Dec 13 23% Dec 17 20% So Porto Rico Sugar. 100 500 70 Dec 17 96% Dec 13 70 Standard Milling 100 200 104 Dec 17 105 Dec 15 104 Submarine Boat_.no par 9,400 8% Dec 17 9% Dec 11 8% Temtor C A FPcl A Dec 14 Dec 11 z94 Dec 15 z48 8% Dec 13 17% Dec 15 79% Dec 15 7% 14% 79% Dec 119% Oct 23% May Apr Apr Apr Mar Nov Nov 12% Jan Dec 24% Dec Dec310 Apr Dec;160 Apr Dec 14 Oct Dec; 47 Apr Dec|420 Aug 22% May 229 Apr Oct Mar Dec 16 For transactions on bonds of (Fourth 4%s) 169 ■■'mm New York, Dec 80 June Dec 111% Jan Dec 148 Jan 275 94.00 94.00 94.00 94.00 94.00 94.00 94.00 94.00 ' *• .«*«»«» m mm m 94.00 9 10 85.30 85.40 85.12 85.24 85A2 85.06 85.10 84.94 85.12 85.02 85.20 84.94 85.20 85.00 - mm. mm mm m m 85.18 1 85.10 27 12 11 85.44 85.34 85.30 85.40 85.60 85.20 Low 85.10 85.12 85.08 85.16 85.10 84.90 85.20 30 67 85.20 85.36 85.14 85.00 1,912 2,651 2,995 1,768 4,268 3,671 88.00 88.50 88.90 88.04 87.84 87.72 87.78 87.76 87.42 87.88 87.90 87.78 87.50 1,972 2,709 85.96 85.96 85.92 85.70 84.84 85.62 85.64 85.26 85.90 85.78 87.90 87.88 Close 88.00 87.98 1,134 1,539 2,919 High 85.96 85.98 Low 85.82 85.64 j ; 85.32 mm High Low 1933-38 85.20 88.08 Close "«• 85.12 1,880 ( Close Total sales In $1,000 units. 85.94 1,988 5,324 6,387 3,871 1,833 6,538 95.42 95.36 95.88 95.20 95.10 95.04 95.30 95.10 > 95.10 95.00 95.00 94.98 95.34 95.20 95.12 95.00 95.02 1,125 1,549 1,601 2,130 1,965 1,452 95.42 95.30 95.20 95.12 95.08 95.02 95.30 95.10 95.10 94.98 94.98 Close 95.32 95.14 95.16 95.00 95.00 95.00 1,163 1,270 1,605 3,502 1,906 2,204 _ j Total sales In $1,000 units. m.mm mm 85.98 85.82 85.50 95.00 94.92 Foreign Exchange.—The market for sterling exchange and strong, with substantial advances in price levels. Continental exchange for the most part followed the lead of sterling, though the improvement was less pronounced. has ruled active To-day's (Friday's) actual for rates sterling 3 43 %@ Paris Bankers' Francs— High for the week (in cents per franc) Low for the week (in cents per franc) Germany Bankers' Marks— High for the week. 6.02% .5.71% .... Low for the week. . .... ___ 6.11 % 6.12 5.79% 5.80 1.41% 1.30% 1.42% 1.31% Amsterdam Bankers' Guilders— High for the week..______ 31.20 Low for the week 29 15-16 31.65 30% 31.75 30% Domestic Exchange.—Chicago, par. St. Louis, 15@25c. per $1,000 discount. Boston, par. San Francisco, par. Montreal, $186.25 per $1,000 premium. Outside Cincinnati, par. Market.—Heavy liquidation at the beginning of the week forced prices down and new low levels were reached some instances. A better tone developed subsequently but prices did not materially improve. Oil stocks were the in principal features. Carib Syndicate sank from 9 to 7% and sold finally at 7%. Gilliland Oil Com. lost a point to 17. Guffey-Gillespie Oil Com. after early loss from 26% to 25H recovered to 26]% and closed to-day at 26. Internat. Petroleum sold down from 16 to 15 and up to 16%, the final figure to-day being 16%. Maracaibo Oil at first receded from 14 to 12%, but recovered to 13342. Merritt Oil lost a point to 11 and ended the week at 11^. Ryan Cons'd declined from 13 to 11 and sold finally ar 1124Salt Creek Producers dropped from 28% to 26 and closed to-day at 26 %. Industrials were without feature and business was small. Mercer Motor sold off from 5% to 1 and closed to-day at 13^. Wm. Farrell & Son Com. lost five points to 11, the final transaction the Com. being at 12. Willys Corp. issues were weak, losing a point to 9 while 1st pref. dropped from 25>2 to 19. The New Standard Oil (Calif.) 7% bonds were traded in for the first time down 100 % to 99% and lat 99 % Mar finally. Nov first time in 11 were days) 3 41% @3 44%. Cotton for payment 3 49% @3 52% and grain for payment 3 49 % @3 52 %. To-day's (Friday's) actual rates for Paris bankers' francs were 5.95@ 6.02% for long and [email protected]% for short. German bankers' marks are not yet quoted for long and short bills. Amsterdam bankers' guilders were [email protected] for long and 31.20(2)31.55 for short. Exchange at Paris on London, 58.05 francs; week's range, 58.05 francs high and 59.40 francs low. * The range for foreign exchange for the week follows: v v Cables. Sterling, Actual— Sixty Days. Cheques. High for the week 3 46% 3 54% 3 53% Low for the week.. i 3 37% 3 45% 3 44% Dec! 57% Dec! 25% Decl 98% exchange 3 46% for sixty days, 3 50% @3 53% for cheques and 3 51% @3 4% for cables. Commercial on banks sight 3 49% @3 52%, sixty days 8 41 %(§> 3 44%, ninety days 3 39% @3 42% and documents for payment (sixty Dec Oct Jan Boston, Philadelphia and Baltimore exchanges page 2402. . mm mm mmm'rn mm mm mm Victory Liberty Loan High 4%% notes of 1922-23 j Low (Victory 4 %s) ( Close Total sales In $1,000 unlts. 3%% notes of 1922-23 High Low (Victory 3 %s) Dec TRANSACTIONS AT THE NEW YORK STOCK EXCHANGE, DAILY, WEEKLY AND YEARLY. see 4%% Jan 100 no Preferred 394 July par Peoria A Eastern Phillips Jones 124 36% May Dec 17 515% 35 par K C Ft S & M pref..100 Kayser (Julius) A Co 100 Kelly Springf 6% pf.100 Kelsey Wheel Inc...100 Kresge (S S) pref.... 100 Liggett & Myers cl B. 100 77 - j Jan 28 Indian Refining 10 Internat Nickel pref. 100 Hydraulic Steel..no 160 m'm 1 (Third 4%s) Dec May General Cigar pref... 100 General Electric rights.. 37,668 Havana ElRy&Lt._ 100 70 Homestake Mining.. 100 600 85.80 86.30 6 4% % bonds of 1928 Mar 42 Dec 101 6 36 510 41 Dec Aug 40 100 86.12 High Total sales in $1,000 unitsFourth Liberty Loan Dec Dec 13 1,200 100 1,000 100 60,300 Preferred... 100 General Chemical... 100 Dec 13 65 9% Dec 15 49 ~ Dec 14 Emerson-Brantlng... 100 Fisher Body pref General Asphalt 40 Jan 8% Dec 13 45% Dec 16 1,300 5,700 86.12 ' Total sales in $1,000 unitsThird Liberty Loan 118% May 1,000 Chicago & Alton 85.70 86.08 Close j 43% May 39 100 86.12 86.28 Low 23 Dec 14 86". 10 86.20 86.00 86.28 - 4% bonds of 1927-42 (Second 4 s) 36 Dec 13 100 1 High Converted 4%% bonds of i 1927-42 (Second 4%s) Dec 13 86.02 86.00 Total sales in $1,000 units. 39 mmmm 86.20 Close Jan 82 no par 4%s) Jan Dec 14 Certain-Teed Prod Second 19% Dec 13 100 mm — m 86.12 Total sales In $1,000 unlts. 30% Dec 13 mm 5 Second Liberty Loan Dec 39 ^ ' Dec 82 ■ 85.26 Lew 9% 100 100 ■. 86.02 mm mmmm High 64% 2% 100 1,336 - 86,28 (First Dec 13 100 89.96 1,662 86.28 4% % 1932-47 Dec 13 50% 89.82 89.90 Low 3 23 89.84 90.10 2,861 r High 10 100104% Dec 13 108% Dec 11 102 Central RR of N J Converted bonds of May 100 Case Thresh Second Feb Dec mm Close Total sales in $1,000 units..'mm Mar 24 V 89.90 ' bonds of Dec 14 2% Dec 14 10 100 Preferred Low 17 90.00 Close Sept Apr Nov 86.02 16 Dec. 90.14 1,711 1932-47 (First 4%s) Apr 22% 89.90 90.08 1,413 ! Jan 100 Preferred 4% % 89.90 90.02 439 mmmm 15 Dec. 90.40 90.02 High . Converted 14 Dec. 90.10 90.00 mmmrnrn* of Total sales in $1,000 units. Apr Nov 154% June Nov 111% Jan Brown Shoe Inc bonds Dec Dec Dec 4% 1932-47 (First 4s) July 90.08 Low 81,000 units ' Converted $ per share. 90.16 at Liberty Loan issues. Close (First 3%s) Lowest. Par. Shares High Liberty Loan 3%% bonus of 1932-47... j—— Week. industrial issues fractionally higher than last week. With exceptions the tendency of prices has been towards are sented. Week ending Dec. 17. bonds have been record again shows a long list of active stocks which have made new low record prices for the year. This occurred on and State %<x\xhzxs7 (Sai^ette. [Vol. 111. Standard Oil of N. Y. 7s also appeared for the to-day's market and eased off from 100to 100. N. Y. N. H. & Hart. 4s were down some 15 points to 50 at the beginning of the week but recovered late to 62 and closed to-day at 60. A complete record of "curb" market transactions for the week will be found on page 2416. New York Stock OCCUPYING THREE PAGES during the week of stocks usually inactive, see preceding page. For record of sales PJ£K Sates HIOH AND LOW SALS PRICK—PER SHARE, NOT PER CENT. Dec. Monday 11 Dec. 9 per share $ per share 80% 813g 7834 75 74% 534 75 6 6i4 78% 85 85 83 84 33% 34% 31 33% 48 48 45 48 9% 10 9% 6% 6% 112% 113% 57% 59 734 734 5 10 6% 6% 111% 112% 5534 57% 80% "81% 74% 74% 81% 74% 584 5% 84% 85 30% 33 4634 48 9% 10% 6% 6% 111% 113 55% 57% 6% 6% 5 7% 18 18 17 18 17 28 29% 4634 25% 25% 38 27% 41% 69 70% 42 70% 71% 108% 108% 107% 107% 75% 74% 74% 534 5% 5% 5% 9% 10 9% 6% 6% 112% 113% 6% 7 112% 6% 46% 9% 56% 38% 68% 5 107 107 7% 17 27 40% 268% ♦102 85 86 85 32 32% 47% 32 47 112 10 6% 112% 112% 2,400 Atlantic Coast Line RR 7% 17% 26% 42% 71% 108 17 39 40% 67% 102% 102% 51,200 23,600 800 "46" 215 218 1 1 1% 1% 3% % 134 1% 2 3% % 1% % 1% 13% 12 12% 11% 13 12% 13% 12% 18% 19 17% 19 18% 19% 13% 18% 13% % % 1% 12% 71% 13 12% 13% 74% 13% 77 13% 74 72 74% 73% 74% 72% 25% 26% 25 25% 25% 25% 25% 26% 26 11 0 23 21% 84% 21% 84% 3% 86 3% 8% 19 45 45% 84% 14 14 26 26% 48% 49 100 100% 48 49% 11% 33s 8% 85% 3% 3% 9 9% 9% 18 3% 5 18% 38 39% 3% *4% 5% 5% 70 71% 3% 10 .18% 43% 9% 21% 21% 84% 3% 10% 83% 3% 18% 19 43% 43% 10 13 18% 73% 26% 9% 72% 26 9, 9% 21% 84% 21% 82% 21% 84 3% 3% 4 10 10 18 18% 43% 44% 12 18% *42% *10% 18% 46 14 *11% 24 *19% 25 •22% 18% 16% 4334 11% 45 40% 13% 11 11% 12 24% 48% 25 23% 23% 24 52% 50 55% 53% 53% 53 54% 99 99% 99 99% 99% 99% 98 99% 49% 43 45% 47 49 47% 48% 46% 11 10% 11 10% 10% 11 68% 4% 11% Dec 18% Dec 91% Nov 5 75% 41% Marl9 17% Oct 4 31% Iron 17 18% 16% 36% 39 37% 5 5 58 58 70 68% 4% par 3% "68% 70% 69" 69 53% *51 64 *50 65 *60 67 ♦57 65 *58 65 *58 62 *58 32 3034 73 , 85% 53% 56 55% 57% 1834 "23" 36 6% 17 17 93% 97 95% 74% 78 40% 77 40 76% 40% 39% 40% 75% 39% 40 39% 40 15 16 17% 16 17% 16% 16% 16% 55% 55% 55% 40 40 40 37 55% 37% 31% 30 32 30 37% 30% 16% 55% 37% 28 30% 30 . 15% 30% • 31% 55% 31 Feb 13 Junel8 8% 65% Oct 900 New Orl Tex A Mex v t C..100 Do Do Nat 54 4,400 ,54% 56% 56 58% 6,700 24 21% 24% ~23% 36% 33 22% 35% 24"" 32 35% 36% 36% 35% 36 35 6 6% 6% 6% 11% 11% "ii% 11% 21 17% 17 17% 38 38% 18 36% 18% 57% 17% 57% 17% 36% 36% 36 40 9% 19% 7% 7% 20% 7% 64% 9% 9% 20 64% 65 64% 65 *9% 10 9% 10 20 64 10 20% 20% 7% 22% 20 15 13% 13% *13% 10 10 10% 10 15% 16% 27 28 24 25% "24% 69 68% 69 9% 68% 9 9 27% 68% 9% 15 16% 15% 16% 33 33 32 26% 15% 15% 49% 26% 49% 49% 30 15% 14 49% •26 15% 49% 27% 24% 1 1 1% 48 55% 26% 15% 26% 15% 49 45 46 27 26 27 1 1 "27% 26% 28 1 1 % 1 1% 1% 1 1 % 1% 46% 47% 1% 1% 47% 47 48% 86% 85 87 "54" 29% 56% 29 30 71 28% 71 71 55% 79% 45% 57% 55% 50 75 59% 57 58 255% 57 r~~7h *7% 122 7% 7 24% 22% 79% 78 78% 122% 126% 2121% 123% 108% 108% 2106% 106% 17% 16% 16% 17% *60% 7% 122 115 8 7 7% *70 - 25 79 80 *115 83 *79 23 24% 22% 273 7% 115 7% 7% 120 6% "7" 115 43% 41% 43% 42% 40% 40% 39 40% 39 39 39% 40% 35% 39% 36 38% 39 40 *50 ' •9 *9 9% 54% 53% 9% 53% 37% 38% 36% 9% 9% 54% 53 53% 8~1% *99% 105 *101 * z79% 9% 9 "79% Bid and asked prices; no 82" *99% 101 9 8% 80 38% *70 75 — 56% *77 49 m 70 55% 46% 75 55% 22% 23% 75% 56% 23% 73 — 9 82 *100 "7% 75 12 % 1221? 107 16% 82% 101 8% sales on this day. 9 "7" *111 116 41% 6% 36% 40 39 6% 56 107% 17% 9% 36" 81% 100% 101% I Ex-rights, 9 38% 39% 9% 51% 9% 53 8% 6% 37% 9% 52% *81 "81" "7% 120 . 37% 90 *80 84" 70 79% 6% 7% 43% 53 " 120% 122 107% 107% 17% 17% 120 7% 42% 9% 30 67 8% 44% 55% "29% 30" 71 49 83 47% 56 *70 *79 47 3,000 7,300 Feb 55 Dec 37 Dec 16 21% Febll 16% Nov * 67% 66% Aug 10 39% Dec 12% Jan Mar Febll 103 Nov 3 32% Mar 9 61 Octl6 33 33% Mar 9 65% 33% Dec Feb 13 33% 23% Janl4 48% Octl6 Oct 4 Oct 2 11 Febll 40 Sept27 10% Dec 64% 15% 6 July July 88% Feb 13 12 Dec 91% 20% 52% 27% 29% Nov 18 Febl4 Feb13 17 Octll 47 Mar22 27% June23 43 Oct22 Feb13 61% May24 110 7% Augl2 Aug 9 7 May20 19% Dec 14 Decl3 8% Feb 13 129% Nov 4 54% Dec Dec Jan Dec 119% Aug 63 Jan 3 15 13 Oct25 Oct 4 34% 23% Oct 5 Oct 8 20% Dec Oct23 15% Sept30 40 Feb 5 20% Dec 32% OctlS Sept27 78 Nov 9 July30 Dec 6% 69% 15% Feb 13 11 Dec 23 50 13 Jan 20 Oct22 Oct 4 Oct 4 118% Nov 4 33% Oct 5 66% Oct 5 1 14 Dec 10% 20% 1 10 73% Dec 49% 11% 20% May24 ......100 pref 25% Dec 27% 7% 7% 14 9% Dec Jan Jan Dec Dec Apr 16 Dec 17 Feb 52% Feb 9 June23 16 Oct May 20 28 Oct 5 17 Jan 100 200 Wisconsin Central., Industrial & Miscellaneous 25 MaylS 48 Oct 2 25 Dec -100 100 Do pref 100 AJax Rubber Inc ... 50 Alaska Gold Mines 10 Alaska Juneau Gold Mln'g. 10 25 Apr 1 29% Apr 1,200 Adams 2,200 1,6.50 4,000 5,400 13,200 15,400 Express Advance Rumely Allied Cbem A Dye no par 100 100 100 Amer Agricultural Cbem..100 Do pref 100 American Beet Sugar 100 Do pref 100 Amer Bosch Magneto..No par American Can ...100 Do pref 100 American Car A Foundry.. 100 Do pref 6,400 Allis-Chalmers Mfg Do pref 800 11,900 600 10,400 100 7.800 18,800 3,000 18,500 900 pref 100 8,500 American Cotton Oil...... 100 Do 100 pref — 100 5,000 Amer Druggists Synd cate. 10 Do 100 100 Do pref 100 10,100 100 1,300 American Ice Do pref 100 3i",6o6 Amer International Corp.-100 10 1,300 Am La France FE 100 3,900 American Linseed 700 American Express 3,900 American Hide A Leather. 100 American Locomotive 100 Do pref 100 American Safety Rasor— 25 Do 82 14,400 100% 100% 400 8% 10.200 8% Decl3 15 81% 81 Do 600 15% 16 100 Western Pacific.. 8,300 Wheeling A Lake Erie Ry.100 Do pref...... ...100 1,100 900 "29" 75% 64 26% 1% 49% 64 15% 1 - 17% 35 28 75% 16% *30 15% *43% 47 17% 17 *26 50 114 17 15% 80 80 9% 26 50 22% 69 15% *75 122% 124 26% 69 9% 17% 26 51 24% 79% 80% 124% 125% 26 69% 15% 80 56% 27~" 9% — ♦70 60% 24% 1,900 15,500 15% 36 56% 80 10 *33 55% •79% 50% 80% 13% 14% «. 17 50 15,300 16,200 17 « 1,600 2,200 20 26% 69% 17% 1,200 44,100 4,500 10 " ■ 100 ..100 100 Twin City Rapid Transit.. 100 Union Pacific..j 100 Do pref... 100 United Railways Invest... 100 Do pref.... 100 Wabash 100 Do pref A 100 Do pref B 100 Western Maryland (n«tc)._ 100 Do 2d pref 100 49,300 Southern Railway Do pref.. 3,600 18,200 Texas A Pacific 19% 13% 26% 25% 1% 29% *71% 58 82% 8 20 •» "9% "9% 44% 86% 1 71 9% 1% 45 28% *13 10% 32 26% 9% 114% 115% 65 64% 9% 8% *19% 20% 7% 7% 14% 10% 7% 7% 7% 27 15% 20% 20% 19% 7% 19% 19% 69 9 Dec 97% 26 "83% Dec 75 20% 17% ♦9 Apr 24 57 15 53% 39 98 18% 44 56 20% 17 8% Feb27 Oct 4 39% Oct 2 84% Sept26 96% 20% 56% "l3" •115 68 58 14% 1034 17% 8 t c 99% 21% 15% Nov Deo 57 115 40 Feb19 97% 41 Oct 15 32 20% 117 70 Dec 13 57 115 41% May 4 15 21% *35% 66% Dec 23% Sept 60% Deo 50 98% 116 OctlS Dec 19% 112 Octl9 73% 77 67 113% 115% 63% 64% 65 95 95% 17% z36% Febl3 Aprl3 50 Oct 7 7 17% 23% 95% Nov 5 57 18 11% 84% Nov 5 44 98% 20% 6% Feb 13 105% Nov20 56% 20% 32 7,500 4 Oct29 64% 66% Junel2 94%, 19% | 17 9% 15% 32,400 2,500 Jan 37% May24 Do pref .......-.100 5,850 100 2,600 Seaboard Air Line.. Do pref.. 100 1,000 11% 100 98% '42,800 Southern Pacific Co 6% ; 14% •108 v Feb 8% 84% Junel6 35% 6% pref 4% 22% Nov 37% Dec 4% Dec 28% Apr 37% Sept23 27% Oct 4 100 100 100 Reading 50 Do 1st pref 50 Do 2d pref 60 St Louis-San Fran tr ctfs.. 100 Preferred A trust ctfs...100 St Louis Southwestern 100 Do Dec 6 100 18,500 Pittsburgh A West Va._ Do pref.. 300 59% 10 60 700 4% Jan Dec 90 .100 100 100 9,800 Pere Marquette v t c..—>100 Do 500 prior pref v t 0 100 56% 2134 1 16,800 Norfolk A Western... 64,200 Northern Pacific 39,514 Pennsylvania 54% 21 46% 97,000 NYNHA Hartford 7,600 N Y Ontario A Western 55 23% 10 1 preferred. Second preferred 71% 83% 123,000 2~4~" 100 100 First 82 20% pref trust ctfs ..100 33,500 New York Central 2,300 N Y Chicago A St Louis... 100 53 19% 64 27 pref.... Dec 19% 70 Oct 4 53 25% 9 37% 6 Febll 82% 31 Nov 95 36 53 21% 90% .100 Rys of Mex 2d pref.. 100 81% 30 Febl3 Feb28 53% 24% 104% Aug 21 Feb21 85% 20 Jan 5 Oct22 Oct 6 Oct 4 112% 65% Febl9 Missouri Kansas A Texas. 100 Deo 40% Dec 18 51 30 10 49% pref.... Feb Dec Nov 40 56% Nov 3 38% July 2 9 Febl3 63 7 13 Dec 13 11 82 18% 24% 40 3% Mar 10 31% 54% 28 Febl3 Febll 85% Dec Decl3 84% 18% 5212 Dec Dec 14 73 20 May 19 30 Dec 52 71% 27% Oct 2 Oct 4 Oct22 Nov 4 Oct 4 Oct 4 Opt 4 3% 80% 77 17% 8% Jan Sept 3 73 *73 6% Decll 13% May 5 16 Dec 7 16% 83% 77 97% Aug 4 40 13% Dec ........100 52 *73 Feb 13 3 80% June23 51% "§0% 28 64 15% ' 17% 11634 9% 77% 27% 22% 39 7% 96% 76% 97 77% 17 95 20 115 20% 16% 97% 16% 57% 19% 21% 58 19% 3984 18 16% 60% 20% 98% 100% 2034 57% 15% 96% 17% 98 78% 17% 17 17 73 83% 16% 80% 100 66 16% 16% 17% 17 16% 16% 35% 8% 5% Apr Oct 6 Decl6 39% May24 94 Aug 9 68 •60 24 50 39,300 Lehigh Valley 100 3,100 Louisville A Nashville 3,643 Manhattan Ry guar......100 100 4,597 Mlnneap A St L (new) 100 300 Minn St P A S S Marie 7,300 5 58% 68 68 40 100 ...100 19,400 52% 55% 100 100 100 17% 58 58 Jan 7 100 37% 5 4% 4% 57% 39% properties-No par 17 60 16% Ore 36 17% 38% 55 1534 65% Junel2 25 Decl3 37,800 Missouri Pacific trust ctfs.100 68 40% 100 9,000 Illinois Central 10,500 Interboro Cons Corp..No Do pref 6,800 11,400 Kansas City Southern Do pref.. 2,700 2,700 38 73% 17%May20 12% Feb 9 21% 11",000 •52 17% ....100 100 1,000 Gulf Mob <fe Nor tr ctfs—100 500 Do Pref 100 3% *60 9734 79*4 40% 1st pref 2d pref Do 21,900 4% 54% 171 % Nov22 12% 4% 68 75% 172% Mar 3% Apr 6% Feb 2% Deo Oct 2 3 ♦58 9534 260% Septl5 9 Jan 3 Oct 2 4% 18 17% 91% Dec 21% Sept20 30% Oct 2 22% Sept20 3% 38% 15% 16% 93% Feb 2 Oct 108 Feb 13 3 68 18% 45 9% 4 *60 17 Dec Decl4 100 5 53 Dec 48 46 Feb24 3% 68 19 54 Oct2l Oct 8 36% Dec 8 3 16% 55% Sept 12% 4% 36 69" Feb 63 Dec 88 16% 3% 18 53% 32 Dec 9 4% 68 54 57 % Nov23 MaylO pref Do 37% *67% 54 98% 47 10% ♦60 52% Oct 4 Mar30 Sept28 5% 3% 5% 50 . 1684 5 Dec 55% Aug 3 3 4% Jan 68 100 100 1,000 Lake Erie A Western Do pref.. ..... 800 68% "3% 3 22% Octl9 35 100 38,800 Great Northern pref 14 98 42% 11% 8 Oct 5 Oct 4 100 25,200 Erie Do 16,200 — 53% 10% 100 Dec pref Do 13,700 4,000 14 *13 10% 1634 59 59 9% 21% 84% 9% 71 11% 1% 12% 18% 26% Q 3% 8% 18% Augll 83% June29 165 FeblO 100 2,100 Denver <fe Rio Grande 1 1% 13% 19 13% 74 86 July 6 100 2d pref Do 20 ♦8% 46 1st pref Do Deo 34% 100 Dulutb 9 S A Atlantic 19% *21 Febll .. % 1% 1234 13 20 300 Delaware Lack & Western. 220% 220% *215 218 215 V, 1% Dec Dec 3% Dec 7% Jan Mar 100 1,600 Colorado A Southern 3,200 Delaware A Hudson 95% 94 116 Deel7 26% 97 June28 98 61% pref Do 95 Nov 100 pref... Do 100 9634 85 62 Do 46" 95% Dec 91% MarlO 120 Jan 6 Dec 17 95 100 Chic St P M & Omaha 27 65% 72% 26% 25 48% Decl3 Decl7 26 25 21 Decl3 38 Nov29 26 64 33% Oct 44% Nov 65 Oct 5 Decl3 25% June26 300 64 17 89 62 *34% 3 Febl3 36 61% 64% 44 7 58 70 64% 44 98% 51% Deo 100 100 *62 58 Dec 8ept27 17% Sept27 14% Oct 15 4% Jan 10 300 Clev Cln Chic A St Louis.. 100 36 5734 Dec 5 70% Nov 5 Do pref trust rects Chicago Great Western 100 Do pref........100 Chicago Milw & St Paul... 100 Do pref ....100 Chicago <fc Northwestern..100 Do pref—100 Chic Rock Isl A Pac 190 7% preferred 100 6% preferred 100 Feb 11 36 55% 10 126% Dec 54 42 58% Marl5 84% 71% 4,600 58 Octl5 17 Mar 13% Marl5 134 Jan 3 41 57 72 60% 6 87% Deo 28% Dec 38% Dec 5% Septl4 110 May20 Febl3 56% 70% 68% 58% Highest 80% Dec 76% fDec 3 54 40% June28 9% Aug31 Febl3 8,200 26% 67% 97% x82% Junel8 27% Feb 13 64 49,400 66% 25% 67% 25% 64 Jan 12% 6ept27 104% Oct 5 49% Oct 15 23% 25% 23% 98% 82 Febl3 6,500 46,700 65% 1919 \ 9 per share s 90% Nov 5 Apr 21 Feb 17 4,400 Lowest S per share May20 5 4 65% 25% 6 9734 72 47 24% 2334 26 $ per share | 76 Feb 11, 100 2,400 8 17% 27% 26% 734 17% 27% 39% 41% 67% 68% 102% 103 24% 25% 66 6734 57 57% 68 27 .100 17,500 Chesapeake «fc Ohio 5" *7% Year Highest 700 Chic A East Illinois trust rects 27 27 Par 54,950 Baltimore A Ohio 100 3,500 Do Pref .-..100 6,500 Brooklyn Rapid Transit... 100 2,700 Certificates of deposit.. 27,500 Canadian Pacific 100 56% 55% "5" "5 "5" 26 60 Railroads. 40,100 Atch Topeka A Santa Fe_.100 3,500 Do pref 100 3,600 Atlanta Birm & Atlantic.,100 85% 32% 47% 47% 57% 56% 57% 6% 5% 7% 17% 28% 6 7% 17% 28 41 71% 7% 7% 74% 5% 5 7% 7% 75 6 85 33% 47% 10% 5% 84% 32% Lowest Shares $ per share 79 80 $ per share 79% 80% SMARM Range for Presume On basis of 100-share lots Week 17 Dec. PER SMAtttS Range since Jan. 1. YORK STOCK EXCHANGE the Friday Thursday Dec. 16 8 per share S per share 80 75 *5% Wednesday Dec. 15 Tuesday Dec. 14 13 8TOCKS - NEW for Saturday 2407 Exchange—Stock Record, Daily, Weekly and Yearly '■■■ " | Lees than 100 abaree. pref. • Bx-d«*. and rights 4 Febll 42% 14 Dec 2 46% Mar29 45 Decl7 72 24% Decl3 88*4 Jan 5 2% Mar24 1 Aug 9 Augll 44% Decl4 85 Dec 15 1 28 69 51 92% Nov 9 Jan Jan 95 Jan28 87 Sept 96% Janl6 x92 Dec 103% Aprl6 62 Jan Oct28 Decl6 3 5 84% Jan 2 84% May 61% Jan 3 42% 3 Jan Apr 9 Feb 4 16% Decl7 54% 61 Aug26 86 9 95 Feb 6 6% 36% Dec 17 Decl7 AuglO Jan Jan 93 116% Dec 81% 128% 147% 35% 30 Jan 3 6 Dec 101 53 Jan 1% Dec 1% Jan 53% 118% Nov 19 37 Jan 66 62% Septl7 105% July 7 7 Jan 66% 92 55% Dec 17 22% Nov20 *73 Mar31 21 Aug 9 Novl9 7tf% Decl6 38% Decl7 75 3 Janl2 7% Mar 15% 175 30% 122 Jan 3 Mar26 298 84% 113 Jan Feb Dec Feb JaD 39% Jan 88 Jan Jan 14 10% Nov Mar 31 76% Sept Jan 3 Jan 3 63% MarlO 13% Jan 71% Jan 37% Aug Feb13 68 Jan 2 54% Jan Deel3 120% Jan 3 62% Feb Novl6 14% Jan22 Apr 7 Jan27 "44% Mar 85 Mar 58 Jan 100 Jan 9 51 Nov20 80 Aug 3 *79% Decl3 96% June 1 8% Deel6 • E* dividend 95 99% 109% 107 Apr 8 Mar 9 17% JunelC • Full paid New York Stock Record—Continued—Page 2 2408 for record of sales during the week of stocks usually inactive, preceding page. see TER LOW AND SALE PRICE—PER SHARE, NOT PER Saturday Monday Tuesday Wednesday Dec. 13 Dec. 14 Dec. 15 Dec. 16 $ per share % per share $ per share % per % per share 9% 9% •70% share 9% 9% 8% 8% 69% 42% 84% 40 69% 42% 84% 81% 82% 81% 82 83 32 32% 31 32 30% 32 x28 83 83 69 69 39 41% . i "83% 84 88 100% 100 100 70% 68 69% 85 79 81 98% 97% 98 70 *80% 98 110% 112 87% 88% 107% 110 64% 61% 114 114 88% 88% 110% 110% 66% 162% 107% 110% 66% 62% 93 34% 6% 6% 92% 33% 6% 6% 20% 52 52 42 10 10% 20% 20 ..mrnm'm mm' " mm "9% 88% 85 85% 54 *98 18% mm m 53 m 101% 101% 100 4 Decl3 100% 14,500 Nov20 50 80 81% 85 87 "80% 115 88 63% 90 34 6% 31 37% 9 14 4 50 800 7 8 2,600 53% 87 89% 95% *98 103 95 *85 52 51 80 81% 81% 4% 10% 8% 83% 5 4% 9 4% 10% 10% 8% 14 9% 81% 4% 10% 8% 13% 61% 23% 68 5 10% 9% 14 13% 14 61% 61 62 21 26% 62% 23% 25% 67% 68 67% 7% 68 13 63 • 7% - - . . . . "37% 38" 6% 36% 6% 37% 36 36% 36% 37% *88 91 88 89 87 87% 87 87% 26% 25% 26 25% 27 27 74% 72% 73% 72% 74% 67 63 63 63 8% 8% 18% 8% 18% 65% 8% 25% 73% 62% 18% 20% 18% 20% 55 20 21 20% 28 28% 26 26 18% 20% 25% 55% 55% 53% 10% 54% 53% 11 11% 63% ■ mmmm m » - «. 11 10 63% 63% 26% 10% 63% . 8% 18% 20% 27% 54% 10% 63 *53 55 *53% 56 *53 55 *74 76 *73 75 *73 75 79 78 79% 6% 6% 'mm .... 60 77% 6% 18% 77% 6% 19% 6% 60 mm 60 78% 61% 18% 60 *98 5% 6 5% 64 5% 65% 63% 98% 99 98 29% 86% 30 89% 85 85% 28% 81% 84% 20% 21% 66% 28% 5% 65 66% 98% 29% *96 19 60% 100 *72 77% 5% 20% 'mm 29% 27% 28% 82 79% 83 116,600 82 82 83 800 20 17% 19 20% 18% 66% 66% *64% 65 54 61% 26% 26% 10% 15% 27% 60% 26% 64% 26% 26% 26% 27 10% 10 10 10% 10% 16 15% 15% 52% 15 15 119 119% 118% 119 49 14% 61% 61% 66% 13% 60% 61% 71 70% 61% 70% 60 71% 61% 71% 60 71% 69% 70% 39 40 38 39% 35% 37 33% ♦77 78% 76% 77 75 75 *18 20 18 18 *18 11 11 20% 66% 14 19* 20% 18% 18% 18% 18% 20" "19" 32% 14% 32% 54% 14% 77% 9% 14% 15 79% 82 ,10% 9% 10 6% 6% 95 94% 101 ....... 48% 50% 29% 29 71 4% 3% 9% 84 45% 11% 48% *29 1 95% 100 9% 6% 30 *10 46% 95% 101 10 6% 30% 18 46% 96% 101 18 6 30% 30 30 47% 49% 71% 22% 31% 21% 22% 71% 21% 31% 31 ... . — - 9 . . 5 .... 4% 3% 9 5 49% 71 71 21% 22% 30% 4% 31% 4 .... 9 5 .... ..... 20% 30% 4% 3% 8% 16% 16% 9% 16% 16% 16% 16 35% 37% 35 36% 16% 36% 16% 38 38 35% *84 90 89 84 84 80 82 17% 7% 16% 17% 16% 17% 8 7 17% 17% 5% 6% *84 17 *75 12% 48% 48% 49 71 ' 30% 5 4% 3% 3% 8% 16% 36% 51% 51 50% 51% 49% 41% 40 41 41 41% 41 16 16% 16% 16% 17% 17% 16% 17% 59 100 9734 June22 Continental Candy Corp No par Products Refining. .100 Corn Do pref Cosden & Co.. No par Sugar Dome Mines, Ltd Elk Horn Coal Corp 10 50 Endlcott-Johnson Do 50 pref 100 Famous Players Lasky No par Do preferred (8%) 100 Federal Mining & Smelting 100 Nov20 80 89% 50% Aug25 56 69 75 Nov July July Nov July Oct Oct Oct 75% 95% 54 x78 93% Mar22 20% Jan 5 7834 5% 98 Apr26 Apr 9 30% 65% 10234 Jan22 100% 46% Oct 113% 29% 50% 43% 91% Dec Do 15 51% 8434 45 Jan Aug Aug Dec Apr Dec June 86% July 106% July 23 Oct Feb 37% Nov 10334 June Oct 110 June 261 Oct Jan 105 July Jan 55 Dec 87% Dec 69% Mar nl50 3 10% Jan 2 23% Dec 16% May 43 July Decl7 28 Jan Decl4 147 Jan 6 80 Decl3 104 Jan 3 101% Aug 107% Novl7 95 Jan 5 83 Dec 123 9 ""'Dec 25 Dec 71T Novl7 June 150 Dec Dec July 91% Dec 17 80 Nov20 134% Mar20 51 Decl 7 Oct Jan «410 Jan 25 38% Jan 23% July 48% July °ct 1731 25 Cigar, Inc Debenture Feb 91 20% 7 Apr 14 Jan21 Aprl7 100 IOI4 Decl6 48 Jan 39% Nov 55 13% Decl4 36% Jan 5 31% Dec 64% July Jan 5 15 Dec 3834 July 49 JunelO 54 Nov20 77% July23 75% Jan 3 47 Jan 95% July 100 pref —100 General Electric 100 General Motors Corp pref. 100 Do temporary ctfs No par Do Novl2 n605 914 Mayl9 13 Apr29 Aps 7 ..No par pref Fisher Body Corp Fisk Rubber Do 433s 9 Aprl5 16% Mar30 4434 Mayl4 1% DeclO 7914 May25 118 Dec 9 64*2 Novl8 1278 Novl9 19% 9434 172 893? 42 3 5 90 Dec 101 Jan 2 144% Feb 176 Aug Oct Jan 3 82 Jan 95 June 82% Feb 94% Apr 56% Jan 93% Mar26 Decl4 85% Jan 6934 Dec 15 94 Apr20 100 Goodrich Co (B F) Do Oct Jan 60» 3334 Decl 6 85% Jan 5 Deb stock (6%)... 100 Deb stock (7%)...100 6 Aug 109% Oct Apr Dec 80 Jan 5 47% 46% Dec 533, Nov 3 32% Dec 47% July 49% Feb 40 Feb 89% Oct 71% July 14*5 Decl3 30_ Novl9 20% Augl 7 16,724 2,100 Sugar...No States Steel tr ctrs__ 100 Haskel & Barker Car.. .No par Hendee Manufacturing 100 Houston Oil of Texas J 00 Hupp Motor Car Corp 10 Indiahoma Refining Inspiration Cons Copper. Internat Agrlcul Corp 5 _ Do pref Inter Harvester Do 20 100 100 (new) 100 pref (new) 100 Int Mercantile Marine Do pref 100 ...100 Internat Motor Truck.No par Do 1st pref -..100 Do 39,596 7,300 700 600 16 1,600 35% 6,900 8% 48% 40% 7% 50 1,500 600 33,400 15,200 13,500 40% 3,300 16% 2d pref 100 International Nickel (The). 25 International Paper 100 Do stamped pref Invincible Oil Corp Iron Products Corp Island Oil & 100 50 84% Jan 102 8 54" Novl9 78% July 8 14% Decl3 46% 70% Dec 17 9% Decl3 61% 10 Decl 4 27 45 Dec 8 88% Novl9 88 100 ' Novl9 11% Aprl9 116% Sept20 23% Apr 9 55? Augll 2934 Decl7 934 142% Apr 6 Apr 8 Aprl4 Apr! 5 Aprl3 110% 115 Jan24 111 "42"% "Feb "78% 10% Jan 48 Jan July 37% July 91 July Jan 149% July Dec 120 June 21% Jan 67% July 92% Feb 128% May Apr 9 2634 Jan 7 9134 Marl 8 20% Dec 33% June 30% Jan 82 Nov 62 Jan 80 July Jan27 34 Dec 65 Nov 7% July 9 Jan 9 15 Dec 48 Mar Decl7 5134 Jan 3 Novl8 111% Jan 5 * 44 281' 170 Apr 7 Nov! 8 84 Jan19 5734 Novl7 71 68 Dec 9 No par 30% Decl6 Dec DeclO Do pref s Jones Bros Tea, 8 51% Jan 3 21% 45% JanlO 38% Dec 91 Mar 100 15 Nov30 30 Jan 5 24% Dec 44 July Kelly-Springfield Tire..25 Temporary 8% preferred 100 34 Decl 7 152% Jan 5 68 Jan 164 Nov 80 Decl5 105 Jan21 101% Dec Kennecott 16% Decl 6 33% Apr 7 27% Nov 534 Dec 13 48% Jan 5 38% Dec July 126% July 4678 Nov20 9134 Jan 5 62% 107% Nov 35 Aug 7 57% Dec DeclS 38% Oct25 Jan 6 33 16 21 Jan 207 JanlO 195 Dec 109% Jan31 107 Jan 36 Apr 12 100 Inc Copper No par Keystone Tire & Rubber.. 10 Lackawanna Steel 100 Laclede Gas (St Louis) 100 1,350 *95 101 *95 101 700 Liggett & Myers Tobacco..100 Do pref 100 10,000 79% ♦1 47% Julyl5 3 Lee Rubber & Tire 16% Feb16 Decl6 4 2,000 16% Nov26 70 2034 10 v t c__ 130 { Less than 100 shares. 45 Dec 14 100 Transp §130 16% 12*8 Jewel Tea, Inc... 130 16% 1778 Nov 17 100 Can, Inc 130 16% Decl5 9 par 8% 15% 41% 17% DeclO 7378 July28 z6% Jan 32% Feb 37% Nov 3434 Feb 39% Feb Jan 5 Jan 14 Aug27 Jan 34 . Bid and asked prices; no sales on this day. Decl7 Nov20 74 65% 9234 Jan 1,600 7% 50% 41 63 52 Jan 2 Jan 3 67 38% 3,100 7 52% -..100 40% 44% 4934 5" 17% 16% Decl7 Dec Decl3 3% " 81 41% Decl4 163? 17l2 Dec 17 17,200 81 52 10 Dec 6 MaylQ 21% 41% 11 22% . 16% 7% 16% 102 - 16% 413? 135 *131 140 130% 130% *130 100 100 100 101% 101% *95 17 17 16% 16% 16% 17 - 85 6% 48% 131 71 22 . 16% 5% 48% 7% 12% 22 " 141% Nov Apr ■ 12% .... 50 Nov 68 25 58 48% 25% 90 Apr 8 Jan 3 Jan 3 100 72 *55 20 6712 July Mar29 Gray & Davis, Inc Greene Cananea Copper 25,500 *68 116% July 114 July Jan Jan 5,700 49% 58 Feb Dec Oct 31 3 700 72 56% 104% 3 10,600 30 5 Jan 5 Jan 3 Jan 11% *55 16% • 96% *67 Dec 9 5% 1934 Junel8 Jan 101% 59 86% Sept 55% 1,500 4,700 74 Jan 10234 50 32 64% DeclO 3,100 *54 87% 57% Jan 6 Decl5 20,200 *68 54% May Jan Jan 18 11% *30 Dec 48% 20% 74 30io 58 19% 3 100 11,200 2,600 73 Jan 6 Jan28 100 76% 9% 6% 30% 38 16% 15 *68 25 No par 100 pref 70% 49 12% 48% Do pref Consolidated Cigar 78% 9% 48% 13% ..No par *14% 49% 12% 48% Coca Cola 100 Columbia Gas & Electric..100 Columbia Graphophone No par 14% 47% 12% No par Gulf 50 12% 100 Colorado Fuel & Iron Guantanamo 11% 48% Jan 37% July 16434 1,400 95% 85% 46 Feb 111% 2,800 1,600 101 28% Octl5 No par 7214 Novl9 Chicago Pneumatic Tool.. 100 60 Nov27 Chile Copper 25 V 714 NOV30 C'hino Copper 5 176s Dec 3 2,900 12% Aug 5 16% Jan 14 11% 12 60 Act 3934 July 108% 61% 55% 12% Janl2 Apr 17 Jan 1043? .100 pref.. 32% 11% 29% 166 Feb 16 6i2 Dec 9 35% Decl 6 8514 Decl7 Do 14 *46 6 75% 54% 29% 10% 9 Jan Nov20 pref 100 Case (J I) Plow WkS—A7© par 30% 30% 30% 10% 10% 46% 46% 95% 96% 100% 100% Jan 63 100 Do 54% 9% 111? 26 pref Granby Cons M S & P 600 100 6 129 1538 Nov20 Petroleum 33 6% Dec 13 414 Nov20 10i8 Sept24 8I2 Decl 3 California 17% *50 31% 4% • 5 *101 "is" vi 1 ^11 12% 13% Dec 100 Butte & Superior Mining.. 10 Caddo Central OH & Ref__ 100 California Packing No par 18% 14% 73 12% 47% - 3% 9% 131 1,900 60 71% 22% . 79 6% *1 A 1 J. 800 76% 18% 18% *56 13% 49% ... 82% 10% *75 *58 ■ 74 22% 29% 15 46 95% 12% 14% 30% 10% 100 11% 60 49% 96 101 13% 51% 15 10 ' 800 15,675 19% 84% 46% 118% 119% 75 15% 115 t c_.5 General 74 82% Apr 7 v ... 1,100 74 14% 80 100 Butte Copper & Zinc Butterlck 2,450 74 31% Burns Bros 54 33% 14 May 86 34% 32 July Aug 92 51 5,900 11,900 36% 14 30 14,515 2% 13% 125,200 60% 6,600 71 6,800 34% 15,600 31 11 10% 14% 13 15 30 750 70% 55% 45% 900 60 31% 13 200 71 14 46% 5 82 60% 30% 54% 9% 6% 1,400 13% 16 6% 30% 13% . 70% 33% 32% 14% 79% '5,400 *11,500 60 56% 15% 13% 3,500 68% 30 102 Dec 85% 67 56 Dec 41 Decl7 69% 13% 18% 14% 30% *67 ■ 20 85% Ocl23 54 119% 120% 119% 120% *67 72% 13% 14 70 Apr 65 25 25% 50 54% 82 14 9634 *81 54 82 70 Oct 4 Sept24 Freeport Texas Co No par Gaston W & W, Inc No par Gen Amer Tank Car ..No par 49 54% 82V 25 54 10% 54% July Sept 116 Dec 10 10% 14% 82 Jan 11 101% 100 10% 15% 2% 51 1 10734 July 12 Oct 108 Do pref.. Cuban-American 7,200 84% *50 9 Jan 12,300 "3,300 "83% 54% 5 Jan Jan Dec *52% 85% 52 Jan 15 2% 55% 593s 25% 81% 82% 118% 119% 66% 66% 12% 13% 114 DeclS 55% 90 Decl7 7 54 96% May 6 Jan 3 1714 28 52 May 2% May Oct 45 100 *25 55% 119 Jan Sept 278% 72% 56 Feb 1% 26 Apr 9 Dec 16 72 82% 110 32% Cuba Cane Sugar 72% 82 105% Nov 5 1% Jan 5 26I4 Dec 1 78'% DeclG 72% 54% Nov22 J2 Aug20 214 Novl7 4834 Decl7 82 72 54 100 No par Crucible Steel of America__100 Do pref-... 100 20,800 71 86 July Oct 72% 55 145 Oct 48 57 Jan 109% July 85% ^2,200 55 11178 June 103 Jan 52% *56 Dec Oct29 102 85 *82 100 130 Jan 51% 2% Jan 5 Nov20 107 45% 71% 14 Oct 102% 102 Decl3 85% 2% 76% May 156% 98 49% 15 "Oct 192% 100 85 5 94% DeclO 7 Jan 15% 47% 25 Apr 9 99 53% §82 10% 148% Jan 60 72 par Dec 13 1034 Sept 85% 2 Jan 85 46 53 2 Jan Jan 5 75 Apr 14 85 14 Feb 64 64% Augl2 DeclO Aprl6 *48 2 92 20% x5 3 14% 51% 15% 176% 80% May 105% 84% 2 2 7 Decl7 99U Nov26 Jan Mar DeclO 50 14 15% Aug Feb 7 Nov2Q 51% 84% 1% 15 Dec 82 58% 3 5 87% 10% 65% 61 Jan 62% 67,300 52 10% 13% 10% 14% 1% 17% Jan17 7534 83 800 *19 52% Jan 74% Dec 15 31,400 100 21 10% 11 *57 *94 19% 54 67% Decl5 48 Do 5~,400 July July Decl7 Continental 82 5% 65% 5% 64% 65 Brooklyn Edison, Inc ..100 Brooklyn Union Gas......100 " 27% 78% I 29 Jan 18 3,900 62 110 Jan 21% 39 2,700 18% 62 *98 *5 10% *58 m 84% 25% 85% 10% 50% m 86% 85% 29% m 61% 30 85 13 ■m 10" 81% 90 94% ' 29 26% ---. ' *82 *85 ' . 61 *98 4,500 30 "26% 30% m 62 100 "Y, 700 5% 84% 84% 7 46% 5% ' Jan Dec 14 49% pref Consolidated Gas (NY) 100 Cons Inter-State Call Mg__10 Consolidated Textile..No par 79" 77% 5% 18% 78% ' Feb 27% Dec 13 Do 81 89% *11 &300 *54 84% 28 6% moo 57 63 57 75" 29 *5 10 63% 70 *55" *72 98 *26 *15 34,150 55 6% *87 *20% 10 11 10% * 98 16 1% 2,700 98 15% 71 5,300 54% 10% 98 100 10% 73% 24,700 26% 5% 10 73% 20% Jan 94% 3 100 9 26% 54% 45% Jan 6is No par 1,100 20% 2 Jan29 8% pref. 100 10,800 65% 10% 16% 53% 87% 20% 26% 54% 79% cum conv Booth Fisheries 75 49,900 12,400 Jan Decl7 Feb24 63 18% 165% 105% 61% 3212 102% 63 8% 169% Dec 11034 June 69 Oct Decl7 DeclS z90 102% 63 18% Jan Aug 3 Cerro de Pasco Cop. Chandler Motor Car 9% Oct 106 Novl9 14,230 18% 20% 26% 54% 314% Dec 51 26 8% 18% Feb 93% 77% July 100 Central Leather. 9% 18% 20% 191% 7 June29 90 600 63 £ Jan 9734 .100 17,800 1,700 75 Jan 283 210 common. .100 8% . 64% ■ Do B 86% . 25% 11 Corp Class pref... 35% . 86% 120% June May 54% Nov ..20 No 85% 25% 73% m 6018 108% May 100 73% mm'- 5% 28 52% 8% 35% 1,500 64% 66% 64 68 5% 66 87 68 68% 26% 9% 54 24% 5% 67 52 62 23% 65% 28% 15% 52% 84% 51% 13% 61 5% 20 16% 13% 62 24 25% 73% 55% 4% 10% 8% 8% 12% 36% 27% 4,100 4,800 1,200 6,500 4,700 3,900 12,700 81 4% 10% 68% 18% 10% 500 85 81 4% 35% 84% *5% 18% 60% *98 85% 84% 10% 16% 81% 10% 9% 75 53% 6% mm 63 *72 79% 83 68 ' mm mm 95 800 21% 8% 3,500 Aug 9 100 Dec 40 pref Do T,706 3% 8514 May20 102 73 Aug 90% Dec 95 10634 Mar22 105 Aprl2 100% Marl8 Jan 9 2,300 102% Decl3 Aug Oct May Jan 9 No par Do 3% 119 Apr 6 Steel 44,000 96% 148% Jan 66% Bethlehem 52 Jan 59% Motors 50% Dec 113% Dec 9 Bethlehem m *100 3% *83 61% 8% 18% m 91 111% Dec 17 Batopilas Mining 52 80% mm 103 3 3% 52 .... Janl9 Aprl4 Jan26 2512 100 104 3,400 93% 35i8 400 *99 % *% 2% 2% 50% 48% 52% I 51 " 8934 July 109% July 47 July 100 preferred Atlantic Fruit Do Dec 50 100 5,700 104 mm 2d 94 25 pref Anaconda Copper Mining. Associated Dry Goods Do 1st preferred Do 61% Dec 33% May 11 1 109 51 mm mm 2% *85 10% Do 3 Jan13 Mar22 142% 11834 92% May22 HMI4 Aug 9 100 3 ,100 109" mm ...... 21 ♦64 Amer Woolen of Mass 100 Barrett Co Chem Ccns ctfs.— Do pref ctfs dep. 94% 108 % 2% 50% 61% 53 *51% .• 87% *98 % 3 *51% 54 54% 94% B..100 Jan 5 Mar30 Jan Highest Decl7 Decl7 66% Novl9 79 -.100 Class 100 26,900 Atl Gulf & W ISS Line 106% 108 Do pref 100 1,600 *54% 57 86% 87% 130,200 Baldwin Locomotive Wks.100 108 53% 85% 108 104 % 2% 1 53 ' 114 3 8 7% 106 55% 3,800 18io 100 (new) Lowest I per share $ per share 26 Dec 47% Oct 79% Dec 94% June DeclS 8312 99*4 —100 Do pref -.100 Amer Writing Paper pref—100 Amer Zinc Lead & Smelt— 25 400 18 18% x 80 100 pref Amer Tobacco.--—— 500 65,200 40 61% 25% 73% 'mi mm 50 53 8% 13% mmm' 35% 40 21% mmm m Do Amer Telephone & Teleg--100 pref 40 18% 95 4% WON** Amer Sumatra Tobacco common 51 *108 95 36% 26 100 Do 2,400 3,200 No par pref Do *38 61% mmm Do 4,300 73,200 ,700 81% -—- 4,485 36% "m mmrnm mm 35% 19% 21 * 5,800 - American Sugar Refining. -100 600 *50 101% 103 3% 3% 100% 10% 14% 7,100 14,850 50 80 9% 82 39 86 5 10% 69 -■ ■mm mm 7% 7% 107% 110% 100% 51 m 3% 82% 4% 10% 68 *80 pref-—-----100 Fdry tern ctfs.33 1-3 Pref temp ctfs 3,200 97% 98% 98 97% 111% 114% 112% 112% 87% 87% 87% 87% ♦108 111 107% 109 60% 61% 63% 62% 92 90% 90% *89 33 33 32% 33 6% 6% 6% .6% 53 *85 34,550 86% 99% 100 83 Do Am Steel 600 mmrnm 83% *80 86 95 .... 99% 100 68% 70 39 89% *88 52% - -V' 4,700 29% 19% 49% mm 9% *% 2% 3 mm "51 95 3% '■ _ 53% 52% *90 83% 28% 37 105% 110 1 ♦% 2% *50 83% 29% 112 94% 108% 110 106% 108 104 102% 102% *100 1 72 31 105% 110% 53% 54% 54 54 2% 83 Decl4 6% m/mmm 8 9% 104% 107% *% Decl6 39 34 ' 51% ■ 2% 68 Amer Smelting & Refining. 100 *90 38 35% 18% " 106% 109% 54 53% 89% 91% Am Smelt Secur pref ser A. 100 33,000 70% *62% mm mm 38 51 42 500 40% * 27% 37% 18% 38% 68% 39% 82% 82% 87% 6% 30% 68% 98% 113 34 Dec 17 68 82% 110 92% 34% 6% 26 .... "38% 93 34 — 34% 8% Year 1919 % per share 40% 89 SHARE Range for Previous Highest share 68 100% 69% 82% 97% 82% 98 97% 110% 114 87% 87% par & Comm Corp .No per 39% 83 % 29% 83% 86% 70 68% Am 8blp 19,700 8% $ 30 100 *78% 8% Par 70 40% x80 85% 100 89 8% 8% Lowest Indus. & Miscell. (Con.) Shares $ per share PER EXCHANGE Week 17 SHAKE Range since Jan. 1. On basis of 100-share lots 41% *68% - 10034 86 100 1 9% 8% 73 43 Friday Dec STOCKS NEW YORK STOCK the CENT. Thursday Dec. 11 Sales for HIGH Loew's Incorporated % Ex-rights. a No par No par Ex-div. and rights. 778 Sept29 127% Nov26 99 16% June21 Decl 3 »Par value $100. 0 Old stock, x Jan 110% Oct 43 83 40 Jan Oct 250% Aug 115 Ex-dlvldend. July 2409 New York Stock Record—Concluded—Page 3 week of stocks usually Inactive, see third page following. For record of sales during the PER SHARE Sales Saturday Monday f Per share Dec. 13 % per share Dec. 15 14 the 10 10% 10% 10% 10% 9% 10% 30 29% *27% *27% 30 *27% 30 103% 103% *103% 105% *103% 105% *103% V:— *128 132 129% 130% *128 101 101 100% 100% 101% 101% *98% 68 58 •57% 62 57% 57% ♦57 57 *57 57 57% 5934 66 70 70 70 70% 71% ♦70 65 69 70% 67% *65 74% ♦95% *95% C*93% *95% 98 16738 163 162% 170% 159% 163% 161 10% *25 30 *25 131 127 127 102 99 200 200 99 2d 15% 12% 15 12 11% 31% 31% 50 51% 95 95 11% 30% 53 *50 "67" "66* 66% 1,300 Manati Sugar *65 70 *65 70 1,200 96% *93% 68" 186,700 162% 166% #160% 163 168% pref Mexican Petroleum *93 15% 15% 11% 12% 49% 49% 9,000 42,400 38,780 15% 15% 15% 12% 31% 11% ,v 12% 30% 49 1,500 30% 3078 30% 49% 93% 14% 28% 49% 49 30% #49% *92% 14% 28% 50 1434 14% 15 28% 28 48 4534 48 48% 28% 49% 84% 85 85 84 84 27% 28% 29% 293/ 29 29% *28 30 70% 2% 70% *67 2% 71 200 3 5,300 15% 14% 14% 28% 28% 28% 48% 49% 87 87 46% #84% ♦27% 30 *67 72 96 *95 96 93% 14% 28% 49% 48 900 48% 1,100 1 3% 48% '"3% "3% 3% 3% &3vx; 3 47 49% 48 48 91 91 *88 68 68 68% 69% 102% 101% 101% *101 834 8% 8% 8% 82 82% 82% 82% 18 18 18 18% 3% 48 95 47 95 *88 *66 71 *66 *88 ' mm-m 50% 50% 51% 34 35% 33% 33% 31% 32% 12% 12% 12 12 12 12 3% 3% 41 4 • 25 3% 79% 76% 79% 76% 72% 71 74 70% 7% 734 3884 38% 8% 39% 37% 34% 29% 35 35 34 29% 29% 28% 20% 19% 20% #73% 14% 34% 30 29% 19% 36 33% 28% 14% 46% 46% 14% 12% 1478 47% 47% 47% 38 38 38 88 85% 12% 13 13 80% 80 81 95 95 32 32% 82% 83 80% 10214 *98 102% "11% 60% 63% 90 19 17% 18% 18% 63% 12% 49% 59% 13 52% 12% 334 3% 13% 18% ^61% 12% 384 15 *12 4 3% 14 15% 93 39% 40 36% 24% 23% 900 54% 16,500 1,400 72 70% 72 68% 70 69% 70% 7,100 61% 83 59% 61% 58% *88% 93 83 87 20% 20 20 18 88% 18% 59% 8778 60,500 92 56% 55% 57% 54% 56% 57% 12 12% 12 12 11% 3% 3% 3% 3% 13% 14% 13% 3% 3 95% 94 39 23% 24% 3 13li. 3 3 92% 39% 95% 39% 24% 38% 24 24% 23% 51 12% ' •78 13% 43 51% 85 80 13% 81 13% 42% 13 13% 13 42% 7% 41% 40% 36 39% 8 9% 8 49 50% 49 51% *80s 83% *80 8% 7 41% 39% 37% 9% 52 83% 8% 7 84 32 31% 32 31 31% 52 53% 52 54% 11% 12% *11 12% 57 18 16% 65 •' _ 65% ' m ■ —-'mm ■ '■mm.'-- "40% 40% 38% 39% 65% 62% 6434 100 31 'mm 39% 39% 80% 78% 79% '' "79% 105% 106% 106% 106% 50% 9% 39% 50% 9% 92 87 88 8% *52 85% 87 87 *52 58 82% 85% 2934 *91 58 *51 84 37% 71 *11 42 52% 13 37% *66 20% 30% Decl4 108% 23% 16 Jan 7734 Nov20 98 Jan 7 93 Dec 51% 72% Sept28 45 Feb Sept24 68 Jan28 80 Dec Decl7 124 Marl9 110 Nov 120 Apr 19 61 63% 93% 38% 61% 39 3 *92% 38 39 63% 65 80 39% 31 95 100 84% 997» 100 63 100% 33% 34% 32 41 41 40 48% Aug 9 Dec 16 82% Dec 9 80 78% 79% % 61% 105% 106% 51 50% 9% 9% 36% 38% 30% 31% 106% 106% 50% 50% 8% 37% 30% *91 9 40% 31 96 96 pref Superior Oil 6,200 96 7% 8% 10 Times Sq Auto Supply.No par Tobacco Products Corp..-100 Do 100 100 pref... -No par Transcontinental OH 36,200 37% C tr ctfs.No par (The) 25 Texas Pacific Coal A OH 35% 116,700 8% 2,400 50 8,600 1,400 Transue A Williams St.No par Union Bag A Paper Corp.. 300 Union 21,800 100 No par OH No par United Fruit 100 United Retail Stores...No par U S Cast I Pipe A Fdy 100 United Alloy Steel 6,600 1,100 Do 100 100 pref U 8 Express 18% 18,100 U S Food Products Corp.. 64% 93% 39% 19,200 U S Industrial 62% 32,200 32 2,200 106% 106 #48% 49 9% 30% 38% 31% 92% 93 8,300 7% Do 1st pref U S Smelting Ref A Do . M pref United States Steel Corp. .100 Do pref ....100 10 23,600 3,300 Utah 44,700 Vanadium Corp 11,110 400 100 No par Virginia-Carolina Chem... 100 Do 800 9,300 Copper Utah Securities v t c 100 pref. 100 Virginia Iron CAC_. V No par Vivaudou lOO 56 51% 55 52 52 83 83% 837* 90% 83% 82 83% 2,800 Western Union Telegraph. 91% 91 3,000 Westlnghouse *51 100 100 100 100 50 —50 United States Rubber 700 79% 244,100 Alcohol pref... 100 U S Realty A ImprovementlOO Do 200 1,635 6% pa 100 Superior 8teel Corp'n 8,800 37% nc . Texas Company 31 9 100 100 Tenn Copp A 99% 100 "78% pref non-voting Wells Fargo Express 93 93 89% 41% 40% 41 40% 41% 41 41% 4078 41% 41 92% 41% 16,200 Westlnghouse Elec A Mfg—50 34% 35% 34 34% 34 35% 34% 35% 34 34% 34% 34% 13,500 White 22 ■V 95% 22 6% 5-% 5% 5% 5% 34,590 31% 5,700 38 3,900 100 32% 37% 37% 31 534 6 534 5% 5% 30% 32 32 33 38 37% 37% 107 107 1071* 108% 40 43 39% 41% 37% 6 31% 31 32% 37 5% 38% , -| 37% 32 38 31 37% 106U IO6I9 . Wlckwlre Spencer "43% 44% *75 80 *55 60 I *75 80 *75 80 *75 58 58 *56 58 *56 •Bid and asked prices; no 39 40% 39 39% 79 75 75 75 76 Do 58 55 56 57 57 pref (new). pref A 100 100 tc„lOO 100 oref B 100 Woolworth (F W) 4,100 Worthlngton P A M v 300 400 5 25 100 WllsonACo.Inc.v t c—No par 1,000 Do 1 Do pref 5 41% 46t* AprlS 85 Dec Feb Mar Mar25 Apr 8 86% Jan 39% Dec 17 126% Jan 9 Dec 10 Feb20 92 Jan 34% Apr 8 Jan31 Septl3 Apr 8 Mar31 Jan 2 July 7 JulylS 45% 76 95% Jan 3 72% Jan 7 Dec 11% 41 Dec 20% 60 13% c57% 53% 13 48% Nov20 80% 51% Mar26 101% 7 Decl6 40% Aug 6 24 Dec 1 8 91% June24 Dec 16 106 7 Decl3 36% Decl3 62 Decl3 20% Dec 14 30% Dec 15 38% 66% 6 Apr20 16% DeclS Decl7 97% 84% Jan Dec Dec Jan 3 87% Jan 75 Jan 63 Jan 6 961* Jan 5 6 22478 Dec Jan Jan 51 Jan 9% *184 38 176 Febll Dec 16 10% Novl8 3978 Novl7 82" Aprl4 127 Oct23 Jan 3 84% Dec 37% Jan 157 Feb 80% Aug 25% Jan 3 14 Jan 55% Apr 7 Apr 6 42% 16% Jan Feb 37% 78% Jan 5 116% Jan 8 #97% ?Aug 6 3578 Nov20 58% Novl8 99% Decl7 29% Dec 10 39% Det'30 78U Decl3 103% Jan 6 96% Dec Jan 69% 143% Apr 8 17% Jan 5 73 Jan 116% Janl3 109 Jan 109 Jan 104% Junel5 *48% Decl7 115% 63% 90 Jan Jan 76 3 66 43% Apr Jan 45 Jan 5 88% Feb Jan28 111% Dec 47% Mar27 3 65% Feb 7 Aug25 14 Oct23 Deol4 97 AprlO 8% 54% Dec 35'4 80% Aprl4 51 112% Jan 7 120% 8eptl7 110 Jan 54 Mar 29% Decl4 91 Decll 76 Febl3 678 Decl7 46% Nov20 31% Dec 19 Novl9 5% 9 80% 21 Jan June 92% Oct23 51% Nov 55% 82 Sept 8 94% Jan Jan 3 401* Jan 69% Mar29 32% Sept20 45 Jan 23% Jan Jan Jan 7 32 Jan 3 26 Dec 7 93 Jan 5 87% 37 DeclO 82% Jan 5 05% 3 Julyl9 110% June Feb Jan Dec 100 103 Dec 7 Mar31 76 119 40% Junt 98i4 May Aprl4 95 75 Decl6 93% 55 Decl6 76 120 Feb Jan 6 112% Dec 1171* July 50 Feb 117 Janl3 88 Jan 98i* Oci Jan Dec 16 104% July 136% May Jan27 145 39 * Less than 100 shares, X Ex-rights, a Ex-dlv. and rights # Bx-div. a Reduced present title July 1 1920 range In cl. prices from July I only; range for Ohio Cities Gas Jsn. 1 to sales on this day. Name changed from Ohio Cities Gas to 41% Steel Willys-Overland (The) Do 40% 50 Motor 74 Jan Jan26 118% 25 80% Julyl3 41 Dec Jan28 113% Mar25 89% Novl9 40% Nov20 95% := Feb Decll Novl3| Dec 14 26 100 91 Jan 6% Mar 168% 94% Air Brake—50 93 .94 79 Dec 12% "63% 82% IQ0%junel7 Jan 44% Sept 84 Aug 90% 48% AuglO 1850 1600 Jan 71% 100 Aprl4 243 Decl3 . 100 Do 400 400 86% 8% #8 32% A Trading...£2 10,200 40% 79 86% 55 23% 100 19% m'm W Sinclair Cons Oil Corp.No par Sloss-Sheffield Steel A Iron 100 92,700 21 Janl3 Decl7 Decl7 7% 70 21% Dec 17 Decl3 Do 46 25% 83% 55% 123% 177* Dec 17 3 Studebaker Corp (The)...100 7% 93% July 7 Decl3 12% 100 Aug Dec Jan 3 49% 11% 100 Standard Oil of N J Mar 68 Janl3 Jan 2 MaylO Aprl2 Junel8 Apr 6 100 preferred Feb 19 Jan 3 124% 2% Shell Transp 104 Jan 6 106% 16% Apr Feb 94 Decl7 Dec 9 87 Feb Mar "68% 63% Nov19 100 100 Feb 12% 100 22% Feb26 34% No par _ 66,900 7 93 t clOO Stromberg-Carburet.. .No par *6% 18% 65% 92% May 3 10 Nov18 27% Dec 13 ..100 v 3,500 7 18% pref 85% Mar #69 *42% July 7 106% Aprl2 107 Nov 3 Decl4 89% 36% 600 93 80% 100 Stewart Warn Sp Corp.No par 42% 64% k Jan24 Jan 5 Aprl2 1041* Feb 2 91% .27% 113% 40% Novl9 *30 Novl9 Steel A Tube of Am pref...l00 42% 94 9934 50 25 400 42 20 *6% 84 NJ...100 Company.. 100 42% 84 Feb 13 Jan Nov22 Sears, Roebuck A Co 36,300 66% 33 13 8 93 2,500 v 44% July 2 54 Replogle Steel. 12,300 198% 200 51% 52% 12 11% 65% -» Dec 10 Republic Iron A Steel Do pref.. 5,000 7% 100% 80 932 30% *6% 18% "8% 85% 7% 7 44% .... 8% 8% 8% 35% 34 98 *80 *41% 105% 106 49% 50% 9 9% 40% 30 *90 3238 91 9% 39% 40% 32% 50% 9% 51 51 12% 39% 64% • "78% 54% 52% 49% 50% 80% 21 20% 30% 30% 196% 198% 32 30% 197% 199 *11 8% 7 42% 34% 8% 19 31 32% 37% *66 20% 20% 80% 7% 36% - v 66 62% 31 7% 7% '•■mm 'mm 39% 64% 30 49% . 7% 43 6% 6% 1634 6434 634 12% 43% *40 44% *6% 20ti 56% ^ 195% 200 193% 195 6% 83 70 31% *6% 18% 51% 38% 21% 38% 7234 *41 50% *80 68 20% 12 9% 38 21% 44 34% 8% 7% 20% *42 37% 9 65 21% 12 34% 36% 62 19584 199% 54% 56% 42% 65 3634 72% 21% 72% 7% 44% 36-% 39% *38 7 7% 42% 8% 43% Jan 59 88% 101% 25 Jan 3 Jan 8 Jan 8 100 100 Remington Typewriter 500 7% 44 *8% *79 13% 7% 37% 8% 81 4234 42% 50% 81 7% 42 7% 42% •80 81 13% 1234 43 7% 85 12% 85 Jan 82% Ray Consolidated Copper.. 10 Do Jan Dec 13 t 19,600 39% 23% 101,800 50 1,100 30,700 50% 48% 48% 49% 49% 4934 87% *79% 87% *82% 85 *81% 87% *81% 87% *81% 604 615 605 610 620 §601 622 6615 §601 §602 5610 §600 103% 103% 102% 103% 102% 10334 103% 103% 102% 103 103% 103% *79 81 79 79 *79 81 79% 79% 79 80% 80% 79 27 26% 26% 26% 26% 26% 26% 27l4 2634 27 27% 27% 28 27 28 28 25 27 29% 30 27% 27% 29 31 42% 40% 39% 42 40% 42% 40% 42% 39% 40% 43 40% •82% Dec 19% Saxon Motor Car Corp-No par 38% 23% *47% Jan 92% Apr 4,400 3 67 Aprl4 Dec Savage Arms Corp 92% Aprl4 30 5,300 3 116% 32 4,200 12 22 27% 3% 82,400 3,100 58% Dec 58% Dec June22 Oct25 13% 1,800 — 89% 3% 93% 39% 24% Do Jan 5 61% JanlO 7% Republic Motor Truck .No par Royal Dutch Co (N Y shares). St Joseph Lead 10 San Cecilia Sugar v t c.No par 'mm J 3% 14% 900 ■ 46 Feb 13 65% Novl9 PublicServ Corp of 200 11% 33 Janl3 7134 Dec Mar 100 Pure Oil (The) *28 70% Apr 8 1,100 Railway Steel Spring #11% Jan 2 45 pref 19,600 11% 78 Nov Aug! 8 Dec 10 81 32 46 Nov20 32-% 11% 34% Jan 2 77 81 *28 Jan 5 65 12 32 100 4178 10 32% mm' 128" 100 31% ' 63 3 97 Do 5% Mar 28% Sept20 Aprl4 157 42% Pressed Steel Car 200 Jan Decl5 Punta Alegre Sugar.. 91% 37% 39% 24% 50% 4,000 54 55 101% 51 3 99 13% ■ Apr 6 9% Nov17 May20 37 pref.............. 100 80 •i'wi-' 46 5 584 Mar 8 Aug 9 30% AuglO 28% Decl3 pref 13% 87 Jan Aprl7 111% 36% Pierce OH Corporation. Do Oct25 77% 22% No par Pullman 12% 61% 44% Mar 47 Jan No par 79% 70 3% 2% 3 98 Do Feb Feb 19% Jan 3 Augl9 12% Dec 14 41% May20 100 Pittsburgh Coal of Pa 500 Do pref 5,700 Pond Creek Coal.. 57% 57% 60 1434 91% 27 1,200 *8934 70% 5 Jan 3 45% t c No par 11,000 12 90 v 13,900 31% Jan 48% 61 100 Penn-Seaboard St'l 46 100 117% 13% NovlO 3,600 99% 101 ' 13% Nov 3% Novl9 23 60 41 83 5 Decl4 107 Jan 93 Jan May20 100 7 17% NovlS 17% ClassB 49 11% 95 Do 46 31% 64% 9,100 m'' - 94 54% 11% 71 69,200 70 101 32% 83 78 Jan 110 40% Nov20 Pacific Teleph A Teleg_._.100 Pan-Am Pet A Trans 60 49% 32% 30 63% Sept Pacific Gas & Electric 70 * io"i% 11% 71 27% 69% 1,900 49 28 30 mm 13% 81% 94 '• n% 11% 30 *90 80 28 11% Jan 182 Pacific Development 101 32% 82% 1103 1,400 - *85 89 13 54 31% 84 7% *85 85% 13% 79 33 13% 47% 57% 13% 83% 84 Jan 3 25 56% 80 ; Aprl2 Steel—.........No par 80% 12% 100% 10134 48% 49% 93% Owens Bottle... 79% 79 50% Otis 12,400 11,900 5,100 12% 80 5,100 3,300 10% 81% 49 14% 74% 10% 56% 10034 101 89% 102% Jan 2 Novll No par 10% 56% „ 45% Dec Feb NovlO Mining 75 77% 71% 7% ' . 8% 66% Novl8 Orpheum Circuit. Inc Otis Elevator 10% 57 *55 Ontario Silver 75 56% 51% ''■mm 400 11 57% 61% 1,100 3,400 73% 56% 85% 102 24,700 Pierce-Arrow M Car 80 Apr 7 88 100 Phillips Petroleum 79 13 100 12,100 78% Jan Dec Decl4 100 19.6 )0 78 70 103 45 preferred 19% 74% 10'% 50% 32% Do 29% 74 101 New York Dock 28% 19% 10 *55" 1,700 2,000 812 Jan 3 Janl3 100 #100% May21 8 Novl8 6 pref Nevada Consol Copper New York Air Brake 18,700 80 102% 100 29% 19% 73 m Do 9 100 pref National Lead 19% 11% m Do Dec Novll 2% Nat Conduit <fc Cable-No par Nat Enam'g & Stamp'g 100 4,000 74 • 66 11,600 10% 10% 27% 100 pref 7% 19% .... Nov Do Decl5 100 National Cloak & Suit 34 72 *85 Jan Sept 87 36% 11% 78% 86 45 33% 75 88 Oct 26 90% Nov 1 otfs dep 35 11% •85% 12% 80% 59 84 preferred 34 73 60 45% Nov20 Do 38 20% *58 Nat Anil & Chem Cons otfs 76% 20 78% 29% 75% #69% 7% 30% 20% 30% Nov Marl9 47% 14% 45% 13% 47% 48 38 7% 100 Mar25 40 Decl4 4034 34 Jan 6 40 3% 47 35% 100% Oct Feb Decl5 Oklahoma Prod <fe Ref of Am.5 70% 7% Decl6 Docl7 75% 38 93% Dec 17 *36% 7% 36% 100 Pref 10% 37% 77% 8 Nov 30 47 38 54 par 47 7% Jan 7 100 37% 37% 34% 69% Nunnally Co (The)....No 37% 7284 Decl7 North American Co 47 72% 49 Nova Scotia Steel A Coal.. 100 16% 70 100 1,166 16% 80% 40% 4,100 15 14% Nov 32 Jan 6 1,300 47% 21 Jan 6 11% 3% 3% Dec 71% 50 15 74% Jan 6 99 52% 30 14% 78% 26 10% 3% 47 4634 Decl3 Jan 10 Aug 5 30t« Nov20 10 60 50 14 4634 37% 75% 15 5 Aug 60 Jan 8 30 46% ' 105 13 14% ' Marl3 32% 48% m — mm Jan 51 14% 46% 14% 4712 14% Jan 162% 88 June 130 Jan 3 31 *11% 3% 50 14% 104 48 *49 14% Janl2 222 #63 Decl6 100 4 4 4 *4 4 4% 24% 24% 25% #25% 25% 24% 125 *123 125 123 *123 123 2534 125 124 107 Aug 9 Dee 14% 2,500 42 Oct29 148 Jan 63 28 200 ' Decl4 50% 52% #3% 4 4 4 126 126 #51 3% 3% 25% 25% 25% 128 mm ♦41 42 42 50% v";''«. '" 25% •126 *40 42 42 46 *39 3% "mm'''-' 68% 13 3% 88 68" 67% 69% 68% *68% 102% *100 102% *100 100% *100 102% *100 8% 83J 8% 884 8% 8% 8% 8% 82 82 81% 81% 81% 81% 82 82% 20 20 20 20 18% 17% 19% 19% 72 Apr 107 Mont Wd&Co Ills Corp.No par National Acme 60 1,350 48 47% 49 88 95 35% 50% 35% *12 3% *47 48% 68% 43% 50% 41 • Feb Decl3 100 pref Do 11,200 84% 48% 84% 5,900 147% 100 Montana Power 700 93% 14% 28% 93% 14% *28 Feb Jan 2 65 100 Miami Copper Middle States Oil Corp Mid vale Steel <fc Ordnance 900 71 98 15 94 66 100 _ Do «• Jan 19 9512 May Department Storm. .100 *93% 25% 40% Dec Jan 3 110% Jan 8 69% Jan 7 64% Mar22 151% Aprl4 137% Aprl9 561* Novll 100 98 31 *28% Decl7 Jan 3 70 Aug25 57 70 15% 11% 11% 98 70 30% 15% 15% 15% 11% __100 28 AuglO pref Do 31 125 Highest 115% 183% Aug2 6 ,._100 Do pre! Mackay Companies Do 038 Nov20 29% Nov18 100 400 300 9 per share 102 Lorlllard (P) 300 $ per share 1919 Lowest -.100 preferred 800 57 67 Do Highest g psr share Indus. 8c Mlscell. (Con.) Par Loft Incorporated.. No par Loose-Wilea Biscuit tr otfs.100 11,500 30 103% 103% 125% 127% *98% 102 Year Lowest Shares $ per share 10 10% 105% *103% 105% •* - 10 10% 30 rnmmm ---- $ per share $ per share % per share Week 17 Dec. 16 Dec. Mange for Previono EXCHANGE Friday Thursday Wednesday Tuesday Dec. 11 Dec. NEW YORK STOCK PER SHARE Range sines Jan. 1 On basis of lOOntAnrs lots STOCKS for HIGH AND LOW SALE PRICES—PEE SHARE, NOT PER CENT. 60 Jan 81 dm 6 Oef n Par 1100. July31. 87: May 20. 50 TA Jan 8. to basis of 825 par 3410 New York Stock Exchange—BOND Record, Friday, Weekly and Yearly 1 1909 if,ie Exchange method, of quoting bonds was changed and prices are now—-"and interest"—except for income and defaulted bonds. Jan. ' Dec. S. Bid Government. Since Last Sale 17 Ask Low BONDS Range Range or Friday EXCHANGE Week ending Deo. 17 II. Week's Price BONDS nr. Y. STOCK Jan No. \Low High Week ending Dec. J D 89.96 Sale 189.82 90.16 94171 89.10110.40 J 3«% of 1932 1947 Conv 4% of 1932 1947 Conv 4tf % of 1932 1947 2d conv 4M% of 1932 1947-.. D 80.02 J D 85.50 86 70 86 02 85,80 Sale 85-26 6 83.00 93.48 10-yr temp secur 6s June.1929 -- 84.00 94.00 Chatt Dlv pur money g 4s 1951 Mac A Nor Dlv 1st g 5s..1946 J J J D 94.00 Sale 94.00 94.00 20 86.00 101.10 M N 85.00 Sale 84-94 85.42 143 81.40 92.90 M N 85.00 Sale 84-90 85.60 17265 8L10 92.86 Mid Ga A Atl Dlv 5s M S 87.50 Sale 87.42 88,90 12153 85.80 95.00 O 85.50 Sale 84.84 85.98 30941 82.00 93.00 fourth Liberty Loan— 95.00 Sale 94.84 95.88 9822 95.00 Sale 9492 95.42,11650 94.64 99.40 <11930 100% *104 105 ..—.—1925 .—.1925 10578 104 Pan Canal 10-30-yr 2s 98% *1936 Pan Canal 10-30-yr 2s reg—1938 99 90 Panama Canal 3s g— 79% 1981 Q M 89 871 Registered ..—..1961 Q M 89 100 Philippine Islands 4fl 1914r'34 Q 81% F coupon.— .... Foreign Government. Argentine Internal 6s of 1909— M Belgium 26-yr ext a f 754 s g.1945 1-year 6% notes—.-Jan 1921 6-year 6% notes.....Jan 1925 Berne (City of) • f 8s 1945 Bordeaux (City of) 15-yr 68.1934 Chinese (Hukuang Ry) 5s of 1911 Chrlatlanla (City) s f 8s 1945 Copenhagen 25-yr s f 554s..1944 105 100% 104 106% Mar'19 M N J D t 79% 80% Mar'20 Feb '15 69% 2 137 29 49 87% 98 94 95% 59, 94 99% 92% Sale 8 76% 1954 J 70% 80% 92% 77 1921 A Switzerland (Govt of) s f 8s 1940 J Tokyo City 6s loan of 1912 M 102 72% Dec'20 61 74% 39 99 77 99 86% 90 92% 98 98% 84| 89% 126 100% 739 99 867„ 97% 99% 102% Guar Tr Co ctfs ofdepIIIII Purch money 1st coa 15s. 1942 Chic A Ind CRy 1st 5s...1936 . 85 Dec'20 ...J 85 95% Chicago Great West 1st 4a__1959 75% 75% 341 69 82 Chlo Ind A Loulsv—Ref 08.1947 74% 75% 664! 67% 82 70 77 Refunding gold 5s 1947 Refunding 4s Series C....1947 56% 204 52% 71 79% 32 79 92% 79 93% 79 76 Jan'20 79 Sale 79 79% 13 J X 41 Sale 40 41% 130 33 Sale 30% 34% 58' 93% 1271 47% 92% 101% 138 102% 45 46 "j M N 97% Sale F A 83% Sale F O 88% Sale F A A O 94% sale 95% Sale 98 449 83% 97% 82% 88% 94% 95% 893 89 648 95 265 53 95% Ind A Loulsv 1st gu 48—1956 29% 50 20 39% 88% 95% 100% 104% 45 92% 99 81% 90% 83 95% 89% 95% 94 Chlo Ind A Sou 50-yr 4a....1956 L ® 4 East 1st 4 H 8--1969 Ch M A St P gen g 4s ser A_el989 Registered Gen'l gold 3Hs Ser B General 4^s Series C Gen Aref Ser A 4Hs Gen ref conv Ser B 5s 01 99 el989 el989 a2014 a2014 Convertible 4Hs Permanent 4s 25-year debenture 1932 1925 4s..I~~1934 Chic A L Sup Dlv g 5s Chic A Mo Riv Dlv 5s 1921 1920 1921 C M A Puget Sd 1st gu 4s. 1949 City Securities. N Y City—454s Corp stock. 1960 454s Corporate stook 1904 4 54 s Corporate stock 1966 454s Corporate stock July 1907 454s Corporate stock 1905 454s Corporate stock 1903 4% Corporate stock 1959 4% Corporate stock.....1958 4% Corporate Btock. 1957 4% Corporate stock reg..1950 4548 Fargo A Sou 85% PI 85% US A -- J 86% 80% 91 94% O -- D 90% 91 M S M N 81% M N 81 PI N 80% M N Sale 83% Dec'20 84 84 90 57 24 82 40 81 81 2 82% Oct *20 91 90% 90% Sale 95 N 8 81% 87% Dec '20 93% Dec '20 93% Dec '20 90% 91% 81% 83% 81 N Canal Improvement 4548-1904 J Canal Improvement 87 82 N 1901 M Canal Imrpovement 4s__.196l J Canal Improvement 4s...1902 J Canal Improvement 4s... 1900 J 87% 20 Sale 1957 M N Y State—4s 85 80 454% Corporate stock...1957 PI 354% Corporate Btook...1954 M 90% 71% 2-3s..l991|J 5e deferred Brown Bros ctfs... I - 82% 89 89% 100% 89% 100% Dec'20 91% assum g 6a_. 1924 Mllw A Nor 1st ext4Hs_.1934 Cons extended 4)<S—.1934 Wis A Minn Dlv g 5s 1921 Chic A N'west Ex 4s._. 1886-*26 Registered 1886-1920 General gold 3Hs 1987 Registered ...©1987 General 4s 1937 Stamped 4s General 5s stamped Sinking fund 6s Registered J D J J J A F J J J J J J J J J J J J O A D D J J J J J J J J D D J F F M Q M M M A A J A A N F N N N O O O O O O N N D 8 O J —1987 1987 1879^1929 1879-1929 Aug'20 71% 81 Sinking fund 5s 1879-1929 A Dec'20 90 90 89 89 Registered Debenture 5s. 1879-1929 A Sept'20 91 June'20 91 91 93 J July'20 Nov'20 93 97 101 108 101 99 Mar'20 99 S 101" mi |102 May'20 100 .... 1101 95 8 64%::::«71% 74% 75%' 75% July'20 Oct 95 '20' Registered 99 107% 95 71% 71% 50 75% 1921 1921 Sinking fund deb 5s 70% 11933 Registered 1933 10-year secured 7s g.. 1930 Des Plalnes Val 1st gu 4Ms *47 Frem Elk AMo V 1st 0S..1933 Man G BAN wist A A M M J M A 3H8.1941 J JSlT A ™l8t Bu 3^8—1941 J ? West 1st MHLS a *1990 Q J 52 Sale 52 52 47% Atchison Topeka A Santa Fe— Gen g 4s ......1995 A O —..1995 A 74% Sale O Registered Adjustment gold 4s *1995 Nov *1995 Stamped Conv gold 4s Conv 4s Issue of 1910— East Okla Dlv lBt Nov 73 75 74 Dec '20 68 69% "14' 69 82% 67% 79 62 73% 68% 69% 43 62 74% D 66% Sale 64% 67% 31 60 70% D 80% 82 65 77% 91 83% 83% 82 89% 64% 71 J 06% Trans Con Short L 1st 4S.1958 J Oal-Arlz 1st A ref 4 54 s"A 1902 PI 66% J 73% Sale 73% 76% S 77 77 77 S 87 5 Fe Pres A Ph 1st g 5s... 1942 M Atl Coast L 1st gold 4s *1952 M S S 10-year secured 7s 1930 PI N Gen unified 454s D 1904 J Ala Mid 1st gu gold 5s...1928 M N Bruns A W 1st gu J gold 4s. 1938 J Charles A Sav 1st gold 78.1930 J J LAN coll gold 48 01952 M N Sav F A W 1st O gold 6s 1934 A 1st gold 6s 1934 A O Bait A Ohio prior J 354 s.. 1925 J 1st 50-year gold 4s *1925 Q *1948 A Registered 10-yr conv 454s *1948 Q 1933 J O Refund A gen 5s Series A .1995 J 771- sale 101 Sale 71% Sale 90 go's 87% Nov'20 76% 77% 101 102 71% 91% 1' ■ 5) 6 "52 19 72% 4 91»- 5 79% Oct '20 75% 107 67 77% 68% 82 82 15 87% 69% 80 95% 103% 68 78% 90% 92% 78 79% 129% Aug'15 67% 70 08% 60% 100% 104% 100% Nov'20 91 99% Oct '20 79% Sale 79% 80% 79% 79 h 64% Sale 81 64 Apr'20 65% 65 60% "73" 98% 101% ::d 91 91 78 85 81 81 J 64 65% 237 5714 88% 89% 187 81% 92% 112 Jan'12 N "74% "77 " 81 Oot *20 61% Sale 60 75 75 Ohio River RR 1st g 5s__. 1930 J General gold 5s 1937 A Pitts Clev A Tol 1st g 6s..1922 A J Sale 85 D 82% O 83 O Tol A Cin dlv 1st ref 4a A. 1959 J J Buffalo R A P gen g 58 1937 M 8 Oonsol 4548 1957 PI N 88 Roch A Pitts 1st gold 68-1921 Oonsol 1st g 6s 1922 Canada Sou cons gu A 5s... 1962 s f 7S..1940 oh *■ Ohio l«t JWV-vf A* A O J F J A J J A D JW J •No price Friday: latest bid and 103 76 46 81 " 84 52 Sale 89 93 80 Spr A Col Dlv 1st g 4s 79 W W Va! Dlv 1st g 4S OI St L A C 1st g 4s 85 85 91% 90% Mar'20 91 91% 90% 90% 52% 92% Nov'20 4484 88% 58% 51% 80 92«4 73% Jan'20 70% 73% 73% 85 79 Apr'20 85 85 99% Nov'20 99% 99 99 "83% 83 83 1 100 109, 83% 99% Sale 99% D 73 74% Nov'20 74% Jan 83% 9984100% 97% 10C Nov'20! O a Due 84 83 94 95% 74% May* 19 90 May'18 97% Juae'17 Sept'20, 76% 85 Dec'20, 79 84 90 100% "83" 97% 100% 84% 87% 88 90 90 93 90% 71 70% Sale 80% Sale 82 05 71% 65% 72% 69% 72% 68% 193 i 3231 70% 71% 79% 82 1 63% July'20| 82% May'19 78% Dec" 19 70 89% 57% 68% 61% 58% 75 72 44% 41 49% 35 69 June'19 70% 70% Nov'20 88% Sept'10 45 Feb'15 43 Sale 95 82% 79 ~6Q% "77% 72 113 65 43% 84 78% 69% 72% Mar'17 86 *63 98% "79" ~86% 78% June'20 Sale 99% 90% 97% Jan*IS Dec'20 "72% d 34 "70"% "71% 29% 40 98 Feb'20 90 70 70% 04 98 73 77% 91 99% 100 09% 75% 4 Due April. «Due May. 79 Sale 79 80% 73 84 907! Oct "77" Sale" 92 83% 78 34 Nov'20. 67 " "82% 41 41 93% 20% 34% 33% Dec '20. 19% 90% 92-% 93% Nov'20 . 87% 72% 72% 76 75% . 68 80 84 - 50 84 85% 60 50 . 50 52 64% 85% M N J J J D J D 50*4 Sale 93% ... 79 *79 J M 1940 M 1940 J J J N S J F| J J O J ...1990 Apr Cleve Short L 1st gu 4Xs._.1961 A Colorado A Sou 1st g 4s 1929 F Refund A Ext 4Xs 1935 M Ft W A Den C 1st g 6s...1921 J Conn A Pas Rlvs 1st g 4s__.1943 A Cuba RR 1st 50-year Be g—1952 O J O A N D O J . 50 . 51 94 50 . __ Mar'20;- 63 Dec'20, 97 80% 68 May'19,. 73 68% 91 79 94 Dec '20 68 72% 68% 72% 65% Sale 73% 68 ~62% "73" 73%i 60 82 72 73% 5934 66% 92% Feb'16, ~53% ~617« 57% Sale 57% 74% Sale 58% Sale 74% 76% 57 59 67% 52% 80 66 65% 64% 66 ) 76 65 68% 79% L 76 83 65% 65% Sale 73% Sale 60 Sale 97% 92 99% Sale 62% 64 58 73% 58% 67% 94% 99% 93% 94% 97h 93% 99% "I 70 97% 93% Feb '20. 99 64 64 Sept'19 Nov'20. . 76% 76% 97% 80 85% 85% 83 > 60% 97% 102 91 . 76% 76% 97% Nov'20 89% 81 73 Sale 94 Sale 76% 64% ~9~0~" 78 ~ llL 79% 87 74% 70 94 84% Apr*20 Apr'10 94% Nov'20 99 96 99 83% Mar'19 91% . 89% * 99 94% 9°t2 94% . 101 88 98 103 . Feb'20j. Dec'20. , 98 " Sale" 99 . 90% 99% 104 90% Nov'20. 102 J2 81 70% 74% 99% 88% 88% 55 81 . 93% 94% 97% 77% . 109% "99 " IIII 75% 8i% 65Jb Apr'19 99 96 " "80* 59% July'20 73 J 94 . 85% 70% 65% Sale 102% 101% Oct'10 101% 102% 101% Dec '20 02 Nov'20. 59% 68 68% 99% Dec *20 »9% 76% 90% . " 161% 101% . 62 62 98% 95% 1 ... 99% 99% .... 91% 97% 98% 74 99% Apr'20 Sept'10 90% 100 98% 98% Dec'20 Sale 74 •74 88 86 69 Sale 68% 70 88 75 | 6534 63 87% 79 65 ' 71 312 60% 95 ~81 " 58 98 55 - 90 87 Sale 1 ! 73 56 88 75% Sale 104 79 78 , 82 ^ 79% 101% Sale 82 75% 65 21 Dec'20 67 90% 87% 65 ,69% May'18| 69% "73"% IIII ms. 85% Nov'16! 100% 101% 101% 55% Sale 73% 71 Sf!" Nov'20! Nov'20; 74 118 67 77% 88 76% 71 70 Feb'19 82 64 62% 62 100 100% 100% Dec '20 79% Sept*20j 79% 86 80 Dec'20 81% 83 ♦81 - J 64% Apr'20 62 100 23 35 — Nov'20 G334 97% ♦81" IIII I. J!~9~6~% 100% | Nov'20 71 98 103 64 52% May'17 Mar'17 81 j Jan'20, 65% 81 68 74 75% 88 Oct 87% 72 10 8 80 "79 90 88 *20| 89 75 69% 71 74 61 66 61% Dec'20 56% 68 71% Dec *20 60% 75 74% Jan '19 84 Nov* 16 76 80 62 Nov'20 70 73 73% "80% IIII 98 .... 54 55 Nov'20 69" 82 82% Sept'19 Nov'20 88" 98 Nov'20 98 "|f" 98 74 F Cin S A CI oons 1st g 5s...1928 J C C C A I gen cons g 08—1934 J Ind B A W 1st pref 48 1940 A OInd A W 1st pref 5s...<11938 Q Peoria A East 1st cons 4s. 1940 A . Mar* 17 79 88 1939 J Dec'20 Nov'20 May'20 85% Oct '20 97% Feb'13 32 64% Sale *1936 Q Income 4s *19' I 76 30% ~64% Sale" *1930 Q Registered l|| 86% Sale 8 ..1929 ClnWAMDlv 1st g4s—1991 St L Dlv 1st coll tr g 4s 1990 69% Mar'20 91% D asked 51% 67% 88 Aug'19 99% Mar'18 94 All A West 1st g 48 gu 1998 Clear A Mah 1st gug 58-1943 *60"" 63 80 ~91% Sale" C Find A Ft W lat gu 4s g 1923 Day A Mich 1st cons 4^s 1931 Clev Cin Ch A St L gen 4s__1993 1931 J 65 S Consol 50-year 4s ClnH AD2dgold4Hs 1993 J N O 88 84 80% J O J D Q M 1952 J J 1937 J J General 5s Series B Ref A lrapt 6s Series A Cairo Dlv 1st gold 4ri 7512 70% J Chic T H A So East 1st 5s..1900 Chic A Wast Ind gen g 6s._el932 20-year deb 4Hs 57% J 8 A 8 J 8 J O C R I F A N W 1st gu U 1921 A O Ch Okla A G cons 5s 1952 M N Keok A Des Moines 1st 5s 1923 A O StPaulAKCShLlst4Hs'41 F A ChlcStPMAOcons0s 1930-1 D Cons 6s reduced to 3Hs_. 1930 J D Debenture 5a 1930 PI 8 North Wisconsin 1st 0s... 1930 J J Superior Short L 1st 5s g.el930 M 8 60 35481925 M Cent Ohio 1st o g 4548—1930 M CI Lor A W con 1st g 58-1933 A J 74% 279 J 1988 Refunding gold 4s 1934 A RI Ark A Louis l8t4Hs_.1934 w Burl C R A N lsr v se 1934 A 60 PLE A W VaSyBref4s..1941 M Southw Dlv 1st gold 3548.1925 J 1922 J Registered 1988 J 57% 65% 88% Sale p—gen 4s 167| 63 Sale L Feb'20 65% Sale D 1929 J Sale 60% _ Pitts Juno 1st gold 6s P June AM Dlv 1st g 58 I960 J g 4S...1928 M Temporary 10-yr 0s Ext A Imp s f gold 5s 1929 Ashland Dlv 1st g 60—1925 1955 J Rocky Mtn Dlv lat 4s... 1905 J Registered 572 69% Sale 69% Sale 80% sale 83% 84% 66% 71 Canadian North deb W F " Mich Dlv ist gold 6s...1924 j Mil Spar A N W 1st gu 4s. 1947 W St L Peo A N W 1st gu 5s 1948 J g 0s_..1921 Rallroad, Ann Arbor 1st g 4s 71% — F A J J M S J J J J J <* J J J 89 J J 93 100% 89% 100% 88 100% 80 90% 79% 91 80% 90 J 4548-1965 J Highway Improv 1454s._1903lM Highway Improv t 454s__ 1965 SI Virginia funded debt 95% 95% — 90 J 75% 98% Dec'20, 97% Dec *20 81 J A O M N el989 Q Chic A P W 1st g 6s of 95to£ State and J Stamped 84% 92% Sale 102 Sale 85 83% 45 1st consol gold 6s........ 1930 General consol 1st 5s 1937 U S Mtg A Tr Co ctfs of dep 75% UKofGt Brit A Ireland— are prices on the basis 87% 84% 937ft 86% 99% 55% 44 70 73 95% 89 Sale J Chic A E 111 ref A imp 4s glll955 U 8 Mtg A Tr Co eta of dep... 86 76% 603; 12 90% *J t~56 " S bee Great North Nebraska Extension 4s_ 1927 113 89% 86% Sale O 78% 70 '""5 62 73 99% 84 High 92 Joint bonds H N Registered H1927 * N. General 4s ...........1958 "* 81 [Lets High 92 82% 80% 98% 97% 35 50 Since Jan. 1 99 J A J J 99 84 N J Chic B A Q—Denver Dlv 48.1922 F Illinois Dlv 3^8 1949 J Illinois Dlv 4s... ..1949 J 1950 39% 75% 75% D Rails.ay 1st lien 3Xs 92 62 78% 75 Range or Last Sale 85 82 76% "7l"% 39, A N 68 96% 101 98% 100 82 N 8 O 63' A X J X 1925 J 1946 J 34' 73% Sale Sale Craig Valley 1st g 5s Potts Creek Br 1st 4s 73 71% 95 70% 100 J 1940 J Sale 84 D D J J J J 79% "61% "62" I Registered 1992 20-year convertible 4H8..1930 30-year conv secured 6s—1946 Big Sandy 1st 4s 1944 J 41 70% 77 98% Sale 87% Sale 1939 1992 39% Sale 89% Sale 80% Sale 1939 Registered.. 92 Sale 76% 99 1st consol gold 5s General gold 4Xs 82% Sale D 78% 78% Sale 40 N Y A Long Br gen g 4s..1941 ChesaAOfund Almpt58—1929 con g 4s...1989 J 2d consol gold 4s 1989 J Greenbrier Ry 1st gu g 4s. 1940 M Warm Springs V 1st g 6s__1941 M OhlcA Alton RR ref g 3s—1949 A 97% 72 do do "German stamp". Sterling loan 4s 1931 j" Lyons (City of) 15-yr 6s 1934 M Marseilles (City of) 15-yr 6s 1934 M Mexico—Exter loan £ 5s of 1899 Q New A1987 R A A Dlv 1st 99% 90% 69% A ...1926 5-year 554% notes 1921 20-year gold bond 654s.. 1937 10-year conv 554s.. 1929 5-year conv 554s pl922 Zurich (City of) sf 8s 1945 89% 87% 99% 87% 94'% Sale Italy (Kingdom of),Ser A 654s'25 F Japanese Govt—£ loan 4%s.l925 F fj hese Registered 92 89% — J J J J J PI N J J Q J J J M S J J M N PI N M S 8 F A A O Coal River Ry 1st gu 4s..1945 July'18 Apr '20 94 N do do ...1931 2-yr 554s gold notes Aug 1921 10-year 554 s 1929 French Republic 25-yr ext 8s 1945 M Gold debt 4s of 1904 Paris (City of) 5-year 6s 100% 101 July'20 Dec '20 96V 69% M Dominican Rep Cone Adm s f 5s 68 Dominion of Canada g 5s.. .1921 Second series 454s.. June'20 96% Sale S D Kxter dt of 5a 1914 ser A..49 F External loan 454 s 1949 do 101% 99% Sale 90% Sale J Cuba—External debt 6s of 1904. M do 94.70 99.40 100 100% Nov*20| 2s oonsol coupon 4s registered 4s 1947 Mobile Dlv 1st g 5s 1946 Cent RR A B of Ga coll g 5s.1937 Cent of N J gen gold 5s 1987 Am Dock A Imp gu 5s... 1921 A of 1933 1938 Liberty Loan— Notes of 1922 1923 Notes of 1922 1923 2s oonsol registered 41930 4\i% Victory 4H % 354 % F A M N Range 17 Ask Low Bid Central of Ga 1st gold 5a__.j>1945 Coneo gold 5s 1945 86.30 1199 Second Llbcry Loan— 4% of 1927 1942 Conv 4>£% of 1927 1942 Third Liberty Loan— 4%% of 1928 Friday Dec. 17 High PI ret Liberty Loan Week's Price N. Y. STOCK EXCHANGE 1 Nov'20 74 74 88 "55"". 47" "67" "57" 27% Dec '20 13 27 82 83% 84 76% 77% 76% 77% 17 74 70 71% 37 66% Sale 71 93% 92 "60 " ~63~% 07 92% Due Jons. I Due Jtdy. tDot Am. (Dm Oet. 16 Dec'20 93 Nov'20 yDue Not. iDn Dee. 73 1 91% 55 89 85% I® »8 "63 ~ "73" s Option saU New York BOND BONDS N. Y. Price STOCK EXCHANGE Week ending Dec. Del Lack & Western— 6s 99i2 lOOM 90% 1923 89i2 *93 .... 675s 99i2 75 1935 8314 Sale 10314 104 10-year secured 7s __1930 Alb A Susq conv 3Ms 1946 Renss A Saratoga 1st 7s__1921 Den & R Gr— 1st 70i8 100 Improvement gold 5s 1st A refunding 5b.___ 8314 8334 103i2 70i2 104 100 1928 1955 61l8 63 65i2 66I2 68 68 43 43U Sale Trust Co certifs of deposit.. Rio Gr June 1st gu 5s Rio Gr Sou 1st gold 4s 1940 40 __1940 *12 Rio Gr West 1st gold 4s_.1939 61 Mtge & coll trust 4s A 1949 Det & Mack—1st lien g 4s__1995 Gold 4s. 199o Registered 73 8712 21 63 4912 2 39 Oct'20 405s Chic A Erie 1st gold 5s. 1982 Cleve & Mahon Vail g 5s. 1938 Erie A Jersey 1st s f 6s.>.1955 77 Sale 76i2 10678 IIII "84"" 35 Dec'20 365s 36i2 42l2 v 77 Jan'17 103 85 57 56 lOOM "51" Sale" 73 51 78 81 29 30 95 34 5334 27 66V 85 Grand Trunk of Can deb 7s 1940 Great Nor C B & Q coll 4s. .1921 1961 Sale 88% Dec'20 8934 91 8oi4 ... 1st guar gold 5s. .1937 Will & S F 1st gold 5S..1938 J Mar'20 7634 82 99>2 97 Feb'20 97 99 ...1951 J Registered....... 1951 J Extended 1st gold 3M8--.1951 A Registered.... 83 79% 83% 70 6234 June'20 84 f 15 70 1952 IV! Purchased lines 3Ms...__l952 J L N O & Texas gold 4s 1953 m 1953 m 15-year secured 5MS-.---1934 80 68 70 73 f Sale 68% n 65is J 67 n h * 73 34 70 661' 68 Sale 66 68 60i2 8778 Sale 87% 62% "40 Dec'20 .1 73 77 J 51 58 58 "2 J 63 63 63 10 Omaha Dlv 1st gold 3s. fi 1951 F St Louis Div A Term g 3s_1951 J 1951 Western Lines 1st g 4s... 1951 Registered..—... Bellev & Car 1st 6s_ 98 102 58 J 60 6212 66 J J 65 F fi 67 58% 62i2 J ......1951 J Springf Div 1st g 3 Ms fi 72l2 75 93% 83 60 6034 69 Dec'20 52 " 62 Joint 1st ref 5s Series A. 1963 T 7814 Memph Div 1st g 4s.__ 1951 J Registered.. 1951 J 6512 81 " 72 St Louis Sou 1st gu g 4s._1931 M Int A Great Nor 1st g ext 7s. 1922 M 89 James Frank A Clear 1st 4s. 1959 J 88 Kansas City Sou 1st gold 3s. 1950 A 19 90 70% 69% 84% 69% 89 74 104 5278 Sale 52% Apr 1950 J 70i2 Sale 69% 71 Kansas City Term 1st 4s...1960 J Lake Erie A West 1st g 5s._1937 J 6914 Sale 69 6934 78 79 80 80 65 72 Nov'20 90 65 82% 78 49% 59 Aug'19 8278 8734 74 12 89 Dec'20 ^Registered """Ref A impt 5s. 1950 78 A ...1941 J North Ohio 1st guar g 5S..1945 A Leh Val N Y 1st gu g 4Ms—1940 J Registered 1940 J 2d gold 5s * No 89U J price Friday; latest bid and aoVcd this 78 o 53 55 1 82% 50 23 26% 45 39 Dec'20 28 53 58 57 Dec'20 45 60 55 Oct'20 55 55 60% 42 Dec'20 33% 67 48% 60 72% 62% Oct'20 20 623g 30 51 Dec'16 37 Oct'20 ... N S 12 79% 87% 79% 3 87% 38 82% 84 51% Sale 82 84 49% 52% 58 "52 " 80 71 85 85 102 69% Sale" 69 6634 Sale 66 80% .... 87 90 91% 893g 51 60 59% "72" "70" "79% 73 Aug'20 85 July'14 70 ---! ..5 48 76% 87 80 95% "66" "76 " Oct'17 67 "52 63% "72"% 80 "2 91 87 102% Sept'20 97% 75% 74 Nov'20 75 72 Dec'20 68 80% 77 84 9734 17% 30 . Jasper Branch 1st J O 4Ms. 1957 J .... 77 71% 92 97 92 Sale 99 1977 J J j 90 1 92 110% Mar* 17 23% Dec'20 J NO A N'Elst ref A imp conv D 6s... 1923 A g IIII "25% 95% 64% 80 25 34% Dec'20 25 40% 24% O 13 3 4% 31 22 Dec'20 15 24 17 17 72 73 72 80 J 59 Sale 58% 60% 67 1925 J D 90 90 9084 96 1935 A O 56 91% Sale "i 56% 20 41% 64 N 90% Sale 86 9334 4MsA '52 73 .. deb 6s. 1935 M .. S 101. 54 Sale 87% 100% 65% A 66% Sale O 73 Sale"" 70% Dec'20 56 90% 102 6684 .73 297 100% 103% 72»4 79 63 58. 69% 82% 147 New York Cent A Hud River— ...1997 J J 66% Sale 65 67 93 1997 J J 65 Sale 65 65 10, 1934 M N 77 Sale 75% 77 ....1934 M Mortgage 3Ms.. Registered N Debenture gold 4s Registered 66% June'20 .1942 J J "70* " 3Ms.—-1998 F A 58% ..1998 F A 57 Registered. Mich Cent coll gold 3MS..1998 F A ..1998 F Battle Cr A Stur 1st gu 3s. 1989 J 59 7234 59% D Registered. 4s. .1936 J J 1936 J Registered 72 Beech Cr Ext 1st g 87% Cart A Ad 1st gu g 4s 1981 J Gouv A Oswe 1st gu g 5s__1942 J guar _ KaAAGR 1st *ni Due June, 1936 J gold 5s h Dae July, .• 1936 J 3Ms_ftl951 A e a 5s.. 1038 J dm Sens. D J 57% 70% 67% 69 .."l 74 13 58% 41 821? 66% 76% 65 76% 55 66 52% May'20 52% 60 54 66 58 ' 58 58 81 59 Aug'20 Feb'20 81 81 49% 82% 73 73 49 12 95% Nov'16 104 May'16 J J O O 58 49 81 J 78 2d 60 73 61% 56% 59% Sale A Registered..... 84 i 96% 97% Sale 83% 74% D 76% ft Due Feb. Oct'20 79% 81 84 June'19 73 89 .... 522 74% Oct'18 68 59 "73 " Sale* 8 A 62% '79" 29"% ~40" " 79% 81 87% Sale J J 68 St L A Cairo guar g 4s..l931 J Nashv Chatt A St L 1st 5s. 1928 J 63% Sent'19 Due Jan. .... 24 Dec'20 Nov'20 76% 72 67 23% 37 86% 51% Beech Creek 1st gu g Oct'09 136 36% Nov'20 26% Nov'20 Lake Shore coll g 74% 93 68% 60% 60% 48% 25 80 30-year deb 4s Dec'20 Oct'20 35% 30% Nov'20 35 Ref A imp 4Mb "A",.....2013 A 88 46% 46% 17 26% Consol 4s Series A.......1998 F Aug'19 74 28% Nov'20 90 19-year coll tr 7s._______ 1930 M Oct'20 74 27% 33% 64% Nov'20 N Y Cent RR 93 77% 23% 25 64 N O Tex A Mexico 1st 6s Nov'17 75 11 33% 90 65 84 *52% "6~3% 56% 3334 137 32% 33 .... 58% Dec"*0 54% 33% 34 68% Non-cum income 5s A 69% Sept'20 75 19.50 J 92% Dec'16 61% 53 Mar'J 9 65 85 J 711927 J Nat of Mex prior lien 4Mb.. 1926 j 1st consol 4s. _.__.__1951 A Nov'10 65% July'18 81% 80% Dec'20 S 1st ext gold 6s 61% 88% "ofij in: 85 89% ..1938 Q Montgomery Div 1st g 5s. 1947 M New Orleans Term 1st 4s._. 1953 J 88 1951 J O Guaranteed general 4s June'16 73 .... Unified A ref gold 4s._.1929 A Registered 1929 J Nat Rys of Mex pr lien 80 54 117% May'10 88 1951 J Ind 111 A Iowa 1st g 4s 68% 79% May'19 92 Chic St L & N O gold 5s__ 1951 J 3Ms 69 74 80% Nov'16 Carb A Shaw 1st gold 4s. .1932 IV! Gold 781 ■» 68 58% Sept'20 Oct'20 1951 F Registered Oct,'20 65 ... 1923 J 59.% 63 "32 91 A J . 91 82% 88% 62 .... O General gold 4s. Dec'20 67 S A . 88 43 "~6 N St L Ir M A S gen con g 5s 1931 J Riv A G Div 1st g 48 1933 J Verdi V I A W 1st g 5s...1926 M Mob A Ohio new gold 6s. 1927 IVI 50% 75 4 8«4 82% St Louis Div 5s......... 1927 F 74% 62 "32 *65 " 74 1938 F 40 77% N . D 3Ms— 62 84 July*09 J Gold 72 62% 1950 J Litchfield Dlv 1st gold 3s. 1951 J Louisv Dlv A Term g 3 Ms 1953 J Middle Dlv reg 5s ...1921 F Cairo Bridge gold 4s __ " 63% Nov'15 95% Sept'12 C S Gen con stamp gug5s_. 1931 C Registered _______1952 A 1st refunding 4s._._ 1955 m .... 78 Dec'20 56 25 50 D 2d extended gold 5s Nov'20 49% 79% .... S D Cent Br U P 1st g 4s.....1948 M Sept'17 ~70" Safe' .1 1938 M 75% 34% 90% Nov'20 85 85 52 N Pac R of Mo 1st ext g 4s__1938 J Oct'18 Nov'20 "69 " II It J 1951 IV! Collateral trust gold 4s 92 C 1951 A sterling 83 83'8 83%*.-. 1945 M 65% 42 2 82 60% 42 Sher Sh A So 1st gu g 5S..1942 J Texas A Okla 1st gu g 5s__1943 M Missouri Pacific (reorg Co)— 42% 5 55 68% 35% 70% 52 O 69 8178 ?, 71 48% 36% Mo K A E 1st gu g 5s M K A Okla 1st guar 5S..1942 IV! M K A T of T 1st gu g 5s. 1942 M 69 J 74% 51 7734 73% June'18 J J Sale A 5934 69 Dec'20 N 68 7312 41% Dall A Waco 1st gu g 5S..1940 M Kan City A Pac 1st g 4s_ 58% IIII 97% 41 36 .. A .... 95 91 Dec'20 31 A *66% 99 95 Sept'20 40% 70% .... O A *6812 J Gen sinking fund 4Mb....1936 J Missouri Pac 40-year 4s 3d 7s extended at 4% 85 Mar'20 91 43% refunding 5s Ser A_. 1965 F 17 July'20 43% 1st A refunding 5s Ser C..1926 F General 4s......... 1975 1V! Dec'20 Nov'10 99 95 .... 70% ... 2004 M Trust Co certfs of deposit 1990^ 1942! A 85% Mar'10 41 30% 1st A refunding 5s Ser Ba_1923 F J 70 46 32% 1st A fi 61 55% Sale 13 711? 65 95 73 71 85% 93% 76% 96 85% 64% 90% Nov'20 67% 43% 86% ..1944 M "ext".. 1916 91 "98~ "98~ 68 89 Mo Kan A Tex—1st gold 4s. 1990 J 2d gold 4s 171990 F Trust Co ctfs of deposit.... notes "88" Oct'20 98 46 .... M S S M A A 1st g 4s int gu '26 J 1st ext gold 5s..'. 1st A refunding 4s Dec'20 97% May'16 ... 99% 92% 67% 41% «77 91% 71i4 Sale 88 95 Sale .. 1941 iv M 7 68 69% 39% M 55 85" "94" 70 9% Nov'20 C 1951 96% 106% 101 70 58 68% Feb'05 70 91% 8 82 12 65% 40 74 70 72 41% Sale 13614 May'06 90is OlM 90 93 9118 Apr'20 1955 F . *82" "83" Dec'20 8912 3 46 4s int gu '38 J f 4b _ 7634 .... 80 68% .. 83% 78 1948 A Houston Belt A Term 1st 58.1937 J Illinois Central 1st gold 4s..1951 J "76% 7812 "89" D 76 88l» 80 92% 1934 1938 5% secured 98 Feb .1999 J 92 Sept'19 101 7984 *94 Trust Co certfs of deposit... St Louis Div 1st ref g 4s. .2001 A 99 83% 74% Debenture ctfs "B"..._. Feb Gulf A S 11st ref A t g 5a..61952 J J Hocking Val 1st cons g 4M8.1999 J J Col A H V 1st ext g 4s Col A Tol 1st ext 4s 99 83 1937 Green Bay & W deb ctfs "A 96% 105% 120% May'16 8034 Dec'20 80 100 Registered 81% June'16 10234 Sept'20 Mont C 1st gu g 6s___„__1937 1st gold 38 8512 88 873s ....1933 1st gold 3M8--— 70 99 *101 ~7o"" _ 78 Dec'20 Pacific ext guar 4s £...1940 E Minn Nor Dlv 1st g 4s. .1948* A Minn Union 1st g 6s .1922 J _ 96l4 82i2 Registered.......... 1937 _ 9678 89 96 Mont ext 1st gold 4s.-.1937 Registered. lo"o~% 9212 10114 10234 10234 1933 1933 Registered. 99% 56! 83 Reduced to gold 4Ms. 1933 ; 105 527,' 95'2 7834 7712 104" " 63% Mississippi Central 1st 5s... 1949 J 96is lOOM 83 "s"o"% 4s._'._ _1933 "64" 9412 9978 9578 "77% 1961 Dec'19 51% 95 100% Sale 95*8 Sale *■ Registered-___________ Jil921 Dec'20 76 Galv Hous A Hend 1st 5s...1933 101% Aug'20 75 92 s 54 76 1 77 refunding gold 4s.__1949 con g 45% 60% 3 ... 99 1st A 1st Chic Term 75% 96% 100% 84 89 Ref A ext 50-yr 5s Ser A..1962 Des M A Ft D 1st gu 4s__1935 J Iowa Central 1st gold 5S..1938 J 1st cons 5s 75% 66% 104 ... 75% 60 M St P A S S M 90 100 84 98% 78 73V 80 100 95% Nov'19 95 48 Dec'20 105 66% 90" Refunding gold 4s.....1951 99 81% 68% Sale 78 67 9l" 85 Dec'20 7034 79 55 67 84% 84"" 83% Stamped guaranteed..... 1977 Midland Term—1st s f g 5s. 1925 Minn St Louis 1st 7s. 1927 Pacific Ext 1st g 6s......1921 Aug'10 64 r59v*63 72 91 *81% 72 99% 103 Dec'20 993s 52 64% June'12 92 5184 88% 66% . 1st consol gold 5s 37 Feb'20 99% 79% 62 60 "l 99% 71% 50-yr 5s...1963 Jan'17 7634 7712 100% 100 A1952 cons gu 104% 70 1987 Lex A East 1st 50-yr 5s gu 1965 LAN AM AM 1st g 4Mb 1945 L A N-South M joint 4s__1952 Registered 75 91% 99% 87% 100 62% 6 8638 Sept'20 99% 73% La A Jef Bdge Co gu g 4s.. .1945 Manila RR—-Sou lines 4s...1936 Nov'19 95 " II— 104 88 .... 83% Kentucky Central gold 4s 80 87 99% 5184 Sale 86 Nov'11 77 92 N Fla A S 1st gu g 5s. 1937 N A C Bdge gen gu 4Mb.. 1945 ~ 87 Mex Internat 1st cons g 4s. .1977 Nov'20 *40 1930 Pensac A Atl 1st gu g 6S..1921 SAN Ala cons gu g 5S...1936 91 Dec'20 108 Sull Co Branch 1st g 5s__1930 Florida E Coast 1st 4Ms.__1959 86 99% 92% 81% Sept'19 89 104% Sale 1930 36 *70% 78% 87 68% 99% Gen Sept'20 Fort St U D Co 1st g 4MS-.1941 Ft Worth A Rio Gr 1st g 4s. 1928 1931 79 51 90 .... 37934 Sale 80% 65 99% Nov'20 90 40 67 92% 78% 56 "89"" "97" 1st gold 6s__,1923 Registered.. 50 - Sept'20 2312 1942 Registered 38 30i8 IIII Atl Knox A Nor 1st g 5s__1946 Hender Bdge 1st s f g 6S..1931 58i2 Dec'19 65 *87" "89" 90% June'19 67% 92% 1940 N O A M 1st gold 6s_. 2d gold 6s 60 Jan'18 72 55 Ev Registered 47 68 86 45 Nov'20 92 .....1940 __ 67 Jan'll ~64% Paducah A Mem Div 4s__1946 St Louis Div 1st gold 6S..1921 2d gold 3s 1980 Atl Knoxv A Cin Div 4s__1955 Dec'06 60 .... 51 73% 87 IIII "88% 10-year secured 7S.......1930 L Cin A Lex gold 4Mb 1931 ; , 7934 47 4612 Feb'20 It" "77" Wilk A East 1st gu g 5s. .1942 & Ind 1st cons gu g 6s. .1926 Evansv A T H 1st cons 6s__1921 921- 61% 95 1937 Registered Jan'18 91 5s. Collateral trust gold 5s. 67% 155 5s Unified gold 4s IO8I2 Sept'19 Dock A Impt 1st ext 5s__1943 1st consol g 6s_.____ 91 "77l2 "79" " 58i2 118 8378 83l2 Nov'20 f 6s._1957 Registered Gold 86 8378 St Paul M A Man 9312 June'16 72i2 35 1st A ref 4 Ms Series A 80 9278 96 .... IIII *65" Nor Sh B 1st con g gu 5s.ol932 Louisiana A Ark 1st g 5s 1927 Louisville A Nashv gen 6S..1930 93 Sale p m deb 69 76 Dec'20 9434 Nov'15 98% Aug'19 51*8 50 4l5g Mt Vernon 56 92 Sale gold 5s 48 "63" "63" " 91% Sale general 68l2 80 36 1st 58 Dec'16 Nov'20 42 Terminal 1st gold 5s...1943 Mid of N J 1st ext 5s._._1940 1932 74 4s Series D..1953 .1940 72% 91 91% Oct'06 65% Nov'20 68% Gen gold 5s 79 64% Oct'20 60 Sale General 77 May'20 72% J91% 99% 67 36 t: 75 98% Sale 99% 55 79 .... 67 50-year conv 4s Ser A.. 1953 do Series B 1953 N Y Susq A W 1st ref 5s.. 1937 2d gold 4M8.____ 1937 73 ~92~ refunding gold 4s...1949 73 N Y & Green L gu g 5s... 1946 80 1938 Registered........ 1949 N Y B A M B 1st con g 58.1935 N Y A R B 1st gold 53.__ 1927 92 ... .A1931 _.... 4s.......... Guar " 80 88 84% 15 5812 6s. .1922 73 Oct'20 "15"" 93l2 40% Sale s Jan'20 Dec'20 84 1928 cur gu "83% "87" gold 5s__ftl931 74 Oct'20 Long Dock consol g 6s.>.1935 87% 1945 cons 59% Jan'20 "72"" "75 " Coal A RR 1st 73 90" 98% "77 " IIII 65 Dec'20 1996 Genesee River 1st ~ 103" 91% Dec'20 91% Sept'20 93 June'20 __ 92 Oct'13 Dec'20 80 ... conv 22 Dec'20 65 99 1st consol gen lien g 4s. 1996 98% 97% 92% 105 Ferry gold 4Mb.........1922 Gold Mar'12 72% 92 Registered 1996 Penn coll trust gold 4s__1951 Sale" 73% 64 8818 Nov'20 ... 50 98% 9234 . j .1933 1st consol gold 4s. General gold 4s 56 88 1996 95 60 10512 Mar'08 —H 78 Nov'20 1920 Registered 8912 66 9312 Yt EA W 1st gfd7s__ 1920 Erie 1st cons g 4s prior 83 92% Nov'20 93 113 Unified gold 4s.......... 1949 84V 96 N 69 1937 76 85% 80 38 60 5 Debenture gold 5s.......1934 Dec'20 82 .... 1937 4th ext gold 5s.... 5tb ext gold 4s 44 Registered Long Isld 1st High 16 77% 20-year 49i2 ~75~% "76"" 93 9978 10514 65 7212 15 100 100U 78 5834 68 11 6278 7278 1 63 7412 8 Low No 68% 77% 89 1st int reduced to 4s.____1933 Leh A N Y 1st guar g 4s 1945 2| High 66 75 49 NY & Erie 1st ext g 4s_._1947 3rd ext gold 4Ms 1923 . 20 ■i 133 63 Elgin Joliet A East 1st g 5a__1911 IV! Erie 1st cods' 1 geld 7s 1920 ■ 8612 Registered Ask Low 68% 77% Sale 68 54 6058 .... Dul Sou Shore & Atl g 5s.-.1937 ' 96% 67 Since Jan. 1 39 Sale 63 Det RIv Tun Ter Tun 4M8.1961 ■ 9434 Range or Last Sale 70is 15 47M . Dul Missabe & Nor gen 5s. .1941 Dul & Iron Range 1st 5s 1937 N 94 Range Week's Friday Dec. 17 17 701s July'20 6ii4 Apr'11 46 "72"" IT— 1939 Guaranteed 100 Sale Dec. Registered 1941 Leh Val RR 10-yr coll 6s__nl928 Leh Val Coal Co 1st gu g 5s. 1933 90 103i2 70i2 72 65i2 Sale 68 Sale 63 4s_1936 1936 cons g Consol gold 4Ms.___ 76 ending ' Dec'20 75% Sale Price STOCK EXCHANGE Week Bid Feb'08 957s .... Y. Lehigh Val (Pa) cons g 4s..2003 IW General cons 4Mb 2003 M Leh V Term Ry 1st gu g 5s. .1941 a 72i2 39. 10218 1922 5s conv . High 63 2411 2 BONDS N. Since 9878 lOOM 9212 9734 Nov'20 _____1943 1st & ref 4s 4 9212 May'20 91 Range Jan. 1 No. Low High 6734 Dec'20 9578 Delaware A Hudson— 1st lien equip g 4mb.. 30-year Ask Low 6734 Sale Term A Improv 4s 1923 Warren 1st ref gu g 3M8—2000 i* Range or Last Sale Bid Morris A Essex 1st gu 3Ms2000 N Y Lack A W 1st 6s 1921 Construction IS Week's Friday Dec. 17 17 Record—Continued—Page 55% 73 66 June'20 75 83% # Due Oct. $ OptJonfsaie. New York BOND Record—Continued—Page 3 Since Jan. I Low 4HRRK {Con)— 09 06 Non-conv deben 4a 1955 J Non-conv deben 4a...... 1956 M Oonv debenture 3Ha—..1956 1945 J 1945 J 60 V 03VI 252 56V 43V 48V 1037 39V Dsc'20 95~" 98 71V 71V 52 60 General gold 6a 53 60V St L A S F RR cona g 92V 1 82 70V 45 44 N 40 Sale 40 39 40 40 60 Sale A 1 M mm m 1 1 — m '65 54'2 J S 55V Sale 35 61 74 74V 51V 77 76 101 .... 100 .... 73 V Sale 102 74 "74V Sale' i02V Safe* 76 Sale III! "73" 74 84V 81 89 Nov'20 68V Sale 08 74V Sale 97V Sale 72V Sale 74 D J 77V 76 J J 76 V 37V 106 81V 10-year Secured 7a AlJeg Val 1942 8 78 V 87V 103V 78V 80 V A 77 85 83 98V 98V 59V Sept'20! 75 89 81V 81V 83 75V 88V 83 78V 88V 73 82 104 V 101 78V 09V Aug'20 D 66V O 77V 80 79V guar 4s ctfa Ser E. 1952 M Gin Leb A Nor gu 4s g__.1942 M N 73V 75V 77 CI A Mar lat gu g 4Ha... 1935 M CI A P gen gu 4Hs Ser A.1942 J Series B 1942 A N A O 60 Jan'20 73V -- 80 86V 86V Feb'20 - 84V Dec'20 — 104 96V 86 Western Dlv lat g 5a 60 81 General gold 90V 88V Feb'17 75 ... ... J J 69V 1940 J J J 69 V .. J 74V ... S N 87V III 1933 1942 P O O A St L gu 4Ha A..1940 1942 1942 Series D 4s guar 1945 Serlea E 3Hs guar gold.1949 Series F guar 4a gold...1953 Serlea G 4a guar 1957 4H8.1903 1970 Ml M*«l 761a 80V II Sept'20 80 80 93 || Union Pacific Mar'10 85V 88V Sept'17 85 V 85 V 84 »5V 84V 84 85 84V 84 80V 74V 80 V 80 V 84V 80 a ... ... 82 — 86 Sale oua/au Ulster A Del 1st lat refunding cona g g 5a 4a lat g 4a 86V 88V II 1947 20-year conv 4a 1927 lat A refunding 4a 02008 10-year perm secured 6a._1928 Ore RR A Nav con g 4a.-1946 Ore Short Line lat g 6a—1922 lat conaol g 5a 1948 90 79V 90 80 82V 78 80 Guar refund 4a 72V May'20 72V 84 Utah A Nor gold 5a 82V 82V 82V 82V Nov'20 76V June'20 73V 82V 76 88 V 80 74V 86 82 S l>ue Fab. 1947 Registered 74V Apr'20 1928 1952 » Da.-Mao. lat extended 4s -L.1929 1920 1933 Vandalla cona g 4a Ser A l955,., Conaola 4s Series B 1957|M Vera Crna A Plat gu 4H8..1934 J iDu.Jalp. «8mAo.. D ie Oct. 90 Nov'20 Nov'20 Nov'20;-;—! 61V 70V 88 21 67 2 89V Dec '20 85V 90 53 97 '20, '2Qj 55V 69V 98V 91V 84V 86V "98" 60 63V 86V 91 97 53 100 96 97V 80V 90V Feb ~8V\ "91 *20| 60 60 "88V "95 104V Dec '10! 87 Nov'20 "84V "90 82 63V 8912 79 Dec'20 85 55 SOU June'20 70 80V 80V 70 Oot '20 70 70 83 Sept'20! 79 83 80 Dec '20 80 62V 87V 74V 81 86 75V 85 35 85 82 80V 66 70 63 92V 90 Aug'19 66 --- 80V 67 79V 102V June'll| — 88V Dec '20 .: 82 82 69 60 V 46V Nov'20 05 81V 897a 90 2 Nov'20 Dec 86 74V 81V 89V 80 V| Dec 7634 55 S 87V Nov'20' 81 76 76V Sale 35 "65V ~70V 70 67 July'20 78V 35 Nov'20 70 70 100V Nov'04 "90V IIII 83V "93~U 75V 80V 65 82 02V 73 90V Dec'20 83 75V Nov'20, 65V 65V 68 64V 65121 Dec'20 89 84 50 36 80V 49V 81V Oct *20 30 15 19 15 Nov'20 15 15 63 65 Nov'20 64V 88 77V Sale 77V 77V 77V 85V 52 52 74V 85V 77 79 64 "38" 3H8.1925JJ 84V 84V Oct '20 80 J J 62V 71*8 65V Dec '20 81V Mar'10| 67 65 ; 80V May'20 1917|F Apr'20 79V May'19 70V Apr'20! 86V Oct '20 87V Nov'19 J 1927 1917 50-year gold 4a 1950, * Coll trust 4a g Ser A Trust co ctfa of deposit 1 --Tor Ham A Buff 1st g 4a__*1940 J 80 ... 1990 A 54 50 90 1935 J 2d 20-year 5a Tol P A W lat gold 4a Tol St L A W pr lien g Dec'12 69 V 69 5s__1935 1935 A 5a Kan A M 1st gu g 4a 84V Feb'12 70 A 1931 5s W Mln W A N W 1st gu 5sl930 F J Tol A Ohio Cent 1st 80 84V 85 1953 4s 67"" 82V F 84V i 160 18 65 65 g 71V 73V 80 1924 cy gu 4a g Dec'15 N 5a..2003 J 90 85V St L M Bridge Ter gu g 5a. 1930 A D Texas A Pac 1st gold 5a 2000 J 2nd gold Income 5s 02000 Mar J La Dlv B L lat 96V May'18i ... .. 1920 M 1936 M 73V 77 90 75V .... 1926 M gu Dec'20j-- J 1945 Spokane Internet lat 9 5a 1955 J Term Asan of St L lat g 4Ha 1939 A 1st cona gold 5a 1894-1944 F J Gen refund s f Nov'19 Nov'20 97 W O A W lat 97V 69V 77 96V 93V 1st cona 50-year 58,-1958 A 98V 71 J Va A So'w'n lat gu 84V 93V 95V 73V 52 General 5s 105 95V 68 4714 Series F 5s 86V 92V 98V 70! o Serlea E 5a 78V 93V 83V 97V Oct *20 69V Mar'20 73V 1946 Virginia Mid Ser D 4-5a._1921 75 82 66V N Rich A Dan deb 5a stmpd. 1927 Rich A Meek lat g 5a 1948 M M 103V 108 02 70V 05 90 86V S35V Sale 87V 1956 1938 Ga Pac Ry 1st g 0a 1922 Knoxv A Ohio 1st g 08—1925 Mob A Blr prior Hen g 5s. 1945 83 66 '8 Sale Mortgage gold 4a 83 A 62 67 E Tenn reorg Hen g 6a Oct* 19 — 66 59 J 62V 85 Ga Midland lat 3s 83 69 81 59/ S 79*4 69 80 J J 08 78 J Cona lat gold 6a 82 75 85 o 4a 83 73 V Sale 81 1948 2d Dec'10 Feb'20 D J D 96 80 V July'19 67V Atl A Yad 1st g guar 4a..1949 E T Va A Ga Dlv g 5a 1930 - 72V 85 A 5a ..1943 cons 96 60 64V 77 Dec'20 93 D 83 J 80 tg 69V 63 .1951 .... 67V Dec '20 78V D O St Loula dlv lat g 4a J 57V Sale Sale 58 09 68 S s 87 70 97 V o 85V 90 81V J 1958 Ser A 86 80V Aug '20 83i2 84V 84V Oct '20 50V 59 57V 59 85 Nov'20 83V Sale 76V 65 J ! gen 4s Sale 69 J Nov'20; 1930 A N Registered.. "7414 Sale J 69 V Sale J J Develop A 100V 98V O 1994 1994 Mar 93V 937i 85 4H31944 90 1908 J O 1950 5a cona g Mob A Ohio coll tr g 4a 1938 Mem Dlv lat g 4 H 3-53—1996 Feb'19 81V J 91 82V l3t 39-year 5a Ser B....1944 Atl A Danv lat g 4a 1948 June'20 ~92~V ~93' 1943 1955 97V 91V 87V Sale 91V Ala Gt 8ou lat 96 08 gold 5a J N Atl ACharl A L lat A 97 70 95V Southern—1st 102V 85 95V 91V 77 82V 00 V 87 95V 99 V 95'2 88V 98V 97 V 97V 83 69 Nov'20 93 83 98V 49V 85V 82V 93»4 82V 94 Sau Fran TermI 1st 4a.. 74 78V ~69~" 84V 81V 85 J Jau'20 77 84V Aug'20 O 81 Nov'19 Nov'18 N 80 Pac RR lat ref 4a 94V 105V '20;«! 72 82V 74V 1921 gold 4a Int guar J Oct '20 64 97 60V Oct '20 84 85V Tex A N O con 70 85 95 97 82V "84 ~ Safe" 84V J 82 104V 70 54 " J J 70 74 Waco A N W dlv lat g 6a *30 A AN W lat gu g 5a 1941 100V 103 67V 80 — ' 70V 73V 81V 93V 117 65V 78 Sept'10; 82V O 74 440; 99V; 377 72%! 213 74 74V 69 V 69 V ,100 Oct '18 84V 1921 99 V 100 100 70V N Louisiana West 1st 08 83 93V J N No of Cal guar g 5s 1938 Ore A Cal lat guar g 5a...1927 So Pac of Cal—Gu g 5a 1937 55 • 73 70V N 62 82 D, 61V 70V Oct '20 75V 84 V 60 53V 76V Sale 70 V 92 69V 97 N 80 Pac Coast lat gu 4s g..l937 76 53V "80" 92 87V 72V Dec Sale General 5a 84V Dec'20 77V Sale 87V Sale 103V Sale I.M b.1 74V M 63 71V 76 87V 70 V **!«■ Dec'20 O 64V 100 104 88V Sale General 5s Series A 51 Dec'19 75V 98V 81V Sale cons guar 86 82V Oct '20 89 Oct '20 79V A 57 70 101V A Series T Dec '15 A 48 74V Dec'20 74V Sale 54 N Serlea O guar A D 5912 Mar'20 96V N Series B guar 69 98 73V 74V 69V Sale j Gen 101V 76 1960 F 1985 J Series O 4s F S D 51 51V 70 75V 77 V 67 90 D M Hous E A W T lat g 59.-.1933 IVI M lat guar 58 red 1933 H A T C lat g 5a Int gu_..1937 Oct '20 74V 4 Ha Genera! 4 Ha 4Ha D J 2d exten 5a guar.. 1931 Gila V G A N lat gu g 53..1924 M Oct '20 72V 49 Nov'20 Through St L 1st gu 4a. 1954 Nov'10 81V Series B 34V Dec'20 122 45 38 62 90 92 Mort guar gold 3Ha_.51929 J Dec'19 101V 109V 101V M 1949 Registered 01V 69V Nov'20 67 Oct '20 50 30 64 60V 61 64 78 20-year conv 5a.... ..1934 Cent Pac lat ref gu g 4a._1949 F 00 V 59 64V 55 493g May'20 74V 86V J Feb'14 02 V N Tol W V A O gu 4Ha A..1931 Registered...........51949 ...01929 Dec'13 Sale ---- 70 82 V— 101 1943 20-year conv 4a__ Nov'20 88 V Ml Ohio Connect 1st gu 4a... 1943 Pitta Y A Ash 1st cons 5a .1927 60 Sept'17 45 99V 1943 Wl 1st gu g 4Ha_1941| 64V 44 37 70 "41V D 3Ha B..1940 69 64l2 J J N Paoflo Coast Co 1st g 5a...1940 J Paduoah A Ilia lat a f 4H8._1955 J ....1950 62 V July'14 Aug'13 83 64V 86V 71V 64 ... Gold 4a (Cent Pac coll)-.fcl949 O M ex 87V Sale G H A 8 A M A P 1st 5a.1931 "36 J Wash Cent lat gold 4a 1948 Q Nor'Pac Term Co lat g 0a.. 1933 J Oregon-Wash 1st A ref 4a... 1981 J lr R A T 1st land grant ext g 5a.. 1930 106V May'15 mm - 98 Erie A Pitts gu g Series C__ 56 50 Conaol gold 5a 81V Southern Pacific Co— 68V Dec '20 — 64V Nov'20,-57V Nov'20, 87 64 55V 64 ' r O 89 F 39V Sale 64 Fla Cent A Pen lat ext 6s. 1923 .... F 194S M 67V Dec'20 98V Jan '13 59V 60 66V 60V 50V 50V 32V 3o V 33V 40 60V 90 100 Oct'19 A 3Ha—1942 49 ... g 4a—1949 49 J | 40-year 61 60 V Caro Cent 1st con July'18 F Guar 3Ha trust ctfa C...1942 J Guar 3Hs trust ctfsD...1944 J Guar 15-2.5-year gold 4a.. 1931 A 60V 58V 59V Sale 59V Sale 67V 50V Sale 1950 00 Q Guar 3 Ha coll trust reg A. 1937 M Guar 3 Ha coll trust BerB. 1941 F 00 39V 48V 58V Sale Ga A Ala Ry 1st con 5a..ol945 Q ...1921 J 66 £5 39V 40 Dec'20 63 55 56 44 67 92V 100 56V 70 Sale 48V 40V 41 Dec'20!— 94 55 34V Sale 52V 46 92V 67 61V 81V 64V Adjustment 5a..... .01949 Refunding 4a......... 1959 AtlA Blrm 30-yr lat g 4s.cl933 40 45V 60 85 Sale 40 40 Sept'20 70 102 66 Ga Car A No 1st gu g 5a..l929 Seaboard A Roan 1st 5s.. 1926 J M 62V Sale 1950 Jao'12 Registered certificates.. 1923 Q it Paul A Duluth lat 6a..1931 Q Int reduced to Seaboard Air Line g 4a 79 Oct* 17 A Series C 3 Ha Series D 3Hs "97V 50 it P A N P gen gold 6a...1923 F Registered 94V 05V 91V 111 1 1 1 111 94 50 40 Northern Paclflo prlof lien rail¬ way A land grant g 4a 1997 Q Registered ...1997 Q D R RR A B'ge lat gu 4a g 1936 F Pennsylv Co gu lat g 4 Ha.'. 1921 J "94 " Safe Gray'a Pt Ter lat gu g 5a. 1947 S A A A Paaa lat gu g 4a 1943 99V Feb'19 97 V June'20 75 V 76V 38 "47" — - 69 95V 82 May'17 lat terminal A unifying £■. 1952 40 4a..1989 M .1948 90 70 J 1929 M .1968 J 07 73 O 77V 91V 81 x 66V 64 46 64V 62V 44 86V Oct '20 04V Nov'20 41 84 90 52 HO , 86V K C A M R A B 1st gu 5a.1929 Jan'09 40 75V 96 86V Sale 95V Sale 40 S 43 93V "n" "88" Oot '20 57V Sale 96 St L S W lat g 4a bond ctfa..1989 2d g 4a Income bond ctfa_pl989 Conaol gold 4a ... 1932 8 A J Oct .1931 43—1996 Gold 4a stamped Pocah C A C Joint 4a.. .1941 J O O A T lat guar gold 6a..1922 J gen guar g 4a... 51960 Income Serlea A 6s 71 95V June'20 67 V 70 \ 1 t 40 93V 72 60V Sale St Loula A San Fran gen 6a. 1931 93V 82 Oct '20 130 V 71V IIII ~64" K C Ft S A M cons g 08.1928 K C Ft S A M Ry ref g 48.1936 1 t I l_ 76 A 4s.....1932 M 4Ha.. .1938 M Oonaol 71 Nov'16 90 V J 1990 A Dlv'l 1st lien A gen g 4a. 1944 J 10-25-year conv 4a 1932 J g 4a.. 1923 02V Sale 4714 Sale 84 Southw Dlv lat g 5a—1947 .... 95V Registered Pennsylvania RR lat Oonaol gold 4a Oonaol gold 4s Cum adjust Ser A 0s..—51955 Dec '20 87V 58 93V Apr'20 97V Dec 'L7 78 79V 84V 67 Improvement A ext g 0a._1934 New River lat gold 6a 1932 A 1st consol gold 4a 71V 60V 71V 84V! Nov'10 68V Sale 1931 M General Hen gold 3s a2047 Registered a2047 Ref A Imp 4H* aer A....2047 it Paul-Duluth DIv g 4s..1990 70V 84V 92V Nov'20 "99" F gu g Sale 84V Sale 82 1955 J Solo V A N E lat 1950 Prior lien Ser C 6a__._.—1928 101 92V Norfolk Sou 1st A ref A 5a..1901 F Norfolk A Sou lat gold 5a..1941 M 10-25-year conv 10-year conv 0a Prior lien Ser B 5s— 103 W A Con Eaat 1st 4H9—1943 J Y O A W ref lat g 4a gl992 M Registered $5,000 only__0l992 M conv 94 Nov'20 Aug'20 60V Nov'20 Providence Term lat 4a.. .1956 IVI 10-20-year 92V 40 80V 75V 66 St Loula A San Fran (reorg Co)— 60 Prov A Springfield 1st 5a. 1922 J 4a..1990 1950 97 98 : 63V Providence Secur deb 4s.. 1957 M oona g Prior Hen Ser A 4a 91V 80V 92 89 St Joe A Grand Isl 1st g 4s_.1947 69V May'15 85 J NYW'cheaAB 1st Ser 14Ha *40 J Boston Terminal lat 4a...1939 A N A W Ry lat 09V Nov'17 113 . orf A West gen gold 6a 64 1997 1997 Registered 36V 34 84V 76 V—79 Sale Jersey Central coll g 4a—.1951 Atlantic City guar 4a g_..1951 J W Y Prov A Boston 4a.__1942 A General 4a.... 81V 81V 71V Oct '20 72 65 Houaatonlc Ry cons g 5a.. 1937 M N Naugatuck RR lat 4a 1954 Ml N 5a Reading Co gen gold 4s 67V 94 IIII "00 Harlem R-Pt Ches lat 4s.l954 cons 72V 72 J B A N Y Air Line lat 4s..1955 Cent New Eng 1st gu 4a..1961 Hartford St Ry lat 4a....1930 M Conao! 4a 63V 79*8 80V Sale 66 Sale 1950 1st Series B 4s 09V F Non-conv deben 4a....1955 Non-conv deben 4a 1956 New England Nov'20 77 79V - 71V Nov'20 { - Philippine Ry 1st 30-yr s f 4a 1937 Pitts Sh A L E 1st g 6s 1940 1st consol gold 6s..1943 81 51921 Pere Marquette 1st Ser A 68.1950 2d gold 4Hs Feb'10 97 Conv debenture 0s......1948!* Cons ,800 9-16 Feb 1 15-16 Apr k Nov 4 46c k k 4 3-16 Blosscm.r 4k 8,560 2k 2k 2,500 100 10c Butler.r 4 3—16 1 17c 1 5c Kewanus.r 1 2c k 1.320 ~35~X 27c 4Kc 5Kc 13c Jan Sept lc 2c 17,600 Kc July 15c Jan Aug Oct 15c Jan 8c Oct 10c 8c 7c 8Kc 39,400 4c 4Kc 4c 4Kc 30,000 4c 1 k Mining.r.j.l 1-16 17 16k 17k 2,100 16 k Dec 39 Apr Jan Copper.r._ 6c 8c 24.900 6c Dec 82c 20c 7c 5Kc 20c 2,000 17c Dec 65c 5Kc 5Kc 3k 1,100 3k 400 New Jersey Zinc.r Nipls8ing Mines Ophir Silver Mines.r 5 7k 7k 6,700 1 7-16 k 7-16 3,200 Prince Consol 2 5-16 k 5-16 3,300 135 135 70 137 7 5c 5c 5c 1-16 1-16 20,100 35 K 25 K 100 35 K Dec 66 K Apr 1 k k k 3,400 1 Aug 3K Jan Silver King Divlde.r 1 7K Nov Jan South Am Gold a Plat.r 10 Pick Cons'd. r 1 Jan 3,000 Jan Silver 97c 3-16 1-16 19 May 3-16 1 12,100 k 3,000 1 8K Nov k 1 7K k k 3-16 Roper Group Mining Bt Croix Silver 7k 7-16 Feb Aug July Rex Consolidated Mln 9,300 Feb 4c Ray Verde Copper IK 3-16 Sept 4k 100 Jan lSg Oct Feb Dec 17,350 Jan IK 6 20 2k ..1 100 Mar Nov 7 Knox Divlde.r 1 Jan 4KcMar 65c 15-16 Jan Lone Star.r Oct 15,050 Jan Nov K KcJuly 12c 17c 15c Jan 78 Sept Jan 25c 78 K 2k 2,000 Dec 15,000 Mar 16 23,000 49 155 K Mar 2c 300 72K 5-16 Oct 8k 25c 50 70 % k 8,200 49 72 k Jan 3,700 30,800 Jan 32 2k 9-16 2c Jumbo Extension Arcadian 650 1 15-16 Jan 19c Honduras Amer Synd.r (t) Howe Sound Co 1 New Sept July Nov 24c" 1 Mar 59 k 19c 36,250 10 150 0?8 62c 3,800 Jan Oct Jan June 26 K Ma* 10 Dec Aug Mar 44c i 6 17,100 Jan 12c ik 30c 1 7-16 1 9-16 k McKinley Darragh Sav_.l 4,700 8 ik 1 1-16 4KcJune 10c June Motherlode Nov 64c 550 11c May 1,000 21,700 55,500 June Dec 7c 3k 23c 7 Aug 13c 19c 45 IK Jan 23c Dec 22 Aug 42o Feb Nov 10K 92c Oct 15o Marsh Mining 15,500 Mar 15c 15c Jan 10K 2K 26 K 30c 18,550 15,500 Dec 5 117 50,500 18c Dec Magma Copper 1,000 Jan 42c lc Apr 6 7c 5c MacNamara Sept 4c 16,200 18,300 Jan 3K Juna 25,850 4K 30 ik 37c Jan k 6c Louisiana Ccnsol 1,500 2k 38c Jan 49a 2Ke Jan 29 k ...... Mar 880 lc 3 Dec ik 4o June 5c IK June IK May Dec 27c 10 2c 2Kc Aug 3-16 May 2Kc Dec 2c Mar IK Dec 62c 15-16 Juna 5c 13 K 64c 1 3-16 Mar Oct May k 1 Zone Divide, r Heel a Mining Iron 3k Dec k June 10c Devel.r Harmlll Divide.r Jim 5Kc ik 28Kc 1 Dec 1,500 100 Dec June 6c 3k 2Kc 9 10 Nov 2,996 2K Jan 13 36 1 1 1 3K 10K 2k 5K Dec "3c" k 500 1 5—16 ... 8K 145 K 145 Mar Sliver Eureka Croesus Mln.r Eureka Holly .r Dec 32 K IK 3K 7K June Emma K 17K IK 30 Roy de France Toilet ProdS Jan 50 47 June 11K 23 K 1 Oct July k , 100 10 1,360 11 73 Indian PackCorp r (no par) 1 8,900 9k 11 15 K 9 27.100 18K Heyden Chem_r__(no par) 5,600 2,800 ik 72 Dec 7-16 Mining Stock*— 73" Dec Jan 10 k Firestone Tire a r, pf.100 Gardner Motor Co. (no par) iiK Jan Jan Mar ♦2k Dec 21 ik ik Dec Dec 1,000 Apr 4 Nov 17 UK 13k k 19 21 85 Dec Dec 6,600 Dec 4K 7k k k 1 July 11K Nov Aug 80 k 7K 21 Jan Dec 13 K Goodyear tar Dec Nov 1,100 5 Oct 2k 73 k k 4,800 Goldwyn Pictures r(no par) 50,400 14k Mar 7k jan 10 k 17 36 K Dec Jan Feb 7,500 19 Gen Asphalt, com.r...100 10,100 6k Mar Mar 1 13K 575 1 10 k k 9 19 16K 37 K 50 22,500 Dec ik 3 k 1 10 (t) Farrell(Wm)ASon com r(t) 16 K 35,200 7k Empire Tube a Steel Dee 7k 81 "*7k 9k 4Kr May 5k Aug ik Aug Jan Jan 26 5 Woodburn Oil 60 14 Preferred ,r 7k 26 Nov Jan 10 Vulcan Oil.r. 1 r 100 7k 1 us Oil Corp Victoria Oil.r 1 . * 1,400 4k 5 Tex-Ken Oil Corp.r Texon Oil a Land _r United Tex Petrol.r 15 1 15 _r 1,700 10k 10 Jan 50 28 k 5 Skelly Oil.r Jan July 26 9k slmms Petroleum r(ijo par) Sinclair Con Oil pref.r. 100 Jan IK k 13 4k 10 9-16 June 5,800 1 k 11 6 Settled Prod.r 4 91 K k K UK 26 k 2 45 1,200 K 11-16 5 Cons'd.r Apr 29 ik Jan Jan Rickard Texas Co.r Sapulpa Refining.r Savoy Oil Dec (t) Feb Nov Mar Nov Candy.r Dec Mar 5 6 United Profit Sharing..25c United Retail Stores k 2k 12 k 5,600 100 7 ik 144 60 Dec Jan UK 7k 6,600 2k 11 7 '•"Ik 1.78 4,100 755 15 k 10 10 3 Dec Nov Nov 100 k 13 k Marland Refining, r 5 Merritt Oil Corp.r ..10 Mexican Eagle Oil.r—, k 14 10 Nov 35 11 Triangle Film Corp v t c.15 Union Carbide a Carb.r(t) United Motors.r..(no par) 1.81 1 (no par) k 1,000 Manhattan Oil.r..(no par) Maracalbo Oil Explor.r(t) 3 Dec 23,900 16,200 3,500 105 Dec Nov Jan Jan ik 1,050 1,500 (t) Todd Ship Corp, new.r.(f) ik 7-16 16k k 1 r new—no 150 Nov 3 Mar 1,140 3,050 Tobacco Prod Exp.r 6k Aug 1 May 36,000 IK Sweets Co of Amer.r..100 Swift International _r 15 Oct 25 k 6K Singer Mfg.r 2 3,000 12 Motor Car.r 20 26k 1 Reo 4 25k 6 Mfg.r 6 Guffey-Gilleeple Oil.r.. (t) Shares. Jan July Clashing Petr Corp « Dec Jan Range since Jan. 1. 7k ik 7k ik 86 k 76 11 Preferred _r ik ik 66 10 Pyrene Apr 72 Crude Chemical, com.r Davles (wm) Co, Inc.r.(t) Profit Sh c a r s.r Apr 13 ik May 1,000 Perfection t a r.r 90 Dec 4k 45 com.r Nov 6 7,600 44 Preferred.r 65 2,600 44 Lima Locom 100 500 5k for Jan 14,300 5k 6 2k Cleveland Auto Co _r 45 Jab 6k 65k Tradlng.r Inter Petrol 15-16 Dec 4k 5,500 Lehigh Coal Sales; 6k Nov 4k 31K 1 12c Grenada Oil Corp cl a.r 10 31 Preferred.r 19c Nov 31k • ' 167,000 1,550 7k 13c 86 Cities Serv Bankers shs r(t) Kay County Gas.r Dec May 79 k July 59 k.July 300 % _ 75 480 2 200 __ com r 100 Griffith (d w) Inc cl a_(t) Hercules Paper.r. (no par) dec Dec 2k Jan Mar 68 10 we 355 Jan 320 Glenrock Oil.r 3K June 29 K Aug 40 Sept Eastern Aug ■ 4.319 Dec 43 East Coast Fish Prod com 350 Nov 400 Preferred 300 388 564 71k 68 320 86 45 Continental Motors.r 230 315 303 330 98 43 Conley Tin Foll.r | Sept Dec Preferred .r.100 (t) (t) 372 79 1,600 25 Nov 95k May 35 Chicago Nipple Mfgcl a 10 240 Federal Oil 34 Chalmers Motor 10 Esmeralda Oil a Gas 100 Car Ltg a Power.r s Jan 245 Oct 31 com.r 278 Jan 28 £1 Carbon Steel Aug May 6K 9 07 k Brlt-AmerTob ord bear -£1 65 195 Nov 27 ..100 Preferred ,r Aug 273 10 245 5 28 100 Co com.r 44 45 90 2,100 40 37 Amer Writ Paper com. 100 Borden 420 198 17K 6 Amalgam Leather com.(f) Am Chicle com.r__(no par) Amer Hawaiian s s.r—10 47 288 5K 38 Packers, r.. (no par) Aluminum Mfrs 45 280 198 286" 92 1 9K Air Reductlon.r..(no par) Allied 2 Feb gMar Jan 6 Week. . High. K Jan 143 63 Elk Basin Petrol.r Sales . 100 Dec Apr Duquesne Oil.r Industrial & Miscell. Acme Dec Dec 90 32,000 Week's Range Low. 83 30 Dec Engineers Petrol Co_r__ Nov Jaa 45 90 105 400 31 18k 84 Apr 1,000 Jan Mar K k Mexico Oil Corp Midwest Refining.r Price. 17k 85 Nov 180,000 Friday Stocks— 2,740 Jan 100 Dec Dec 7k Jan v'i v:V-V of Prices Dec K 27,200 Jan . Last 10 20,100 Hudson Oil.r Sale. 19 1,000 K 30 give a .ecord of the transactions in the outside security market from Dec. 11 to Dec. 17, both inclusive. It covers the week ending Friday Week ending Dec. 17. 1,255 k June New York "Curb" Market.—Below afternoon. Jan 7k 80 Dec 71k 1k 100 % 2 Jaa 26 K k Denny Oil.r Apr Jan 5H Dec t'ik g'arlb 110 4K Dec 6 ... Cosden a Co, com.r May Nov 9 Oil.r..i Jan Jan 105 Natl Properties 4~6s__1946 Penn rr 10-year 7s.. 1930 Boston-Wyoming Jan 109 1 2K 17 k 10 Carib Syndicate.r 90 k 102 k 3,000 26,000 2,500 90 90 Atlantic Gulf Oil Corp. 100 71 65 53 Dec 11 Dec 49 k Dec Oct l Other Oil Stock* Allied Oil.r 1 Arkansas Natural Gas.r. 10 4s. 1945 Lake Superior Dec Dec Standard Oil (Calif).r. 100 Standard Oil (Ind) new..25 Standard Oil of n y.r.100 64 2,000 54 Jan Dec 25 50 11,000 1,000 64 Jan 82 65k Inter-State Rys coll 4s. 1943 Elec a Peop tr ctfs Jan Jan 6 4,400 7,900 83 Prairie Pipe Line.r.... 100 South Penn Oil.r 100 Oct 2,000 4m 64 Ohio Oil.r 15,000 70 65k 84 k 101k 102 Chic Great West 4s... 1959 Jan Jan 79 84 k 1945 Bklyn Rapid Tran 78.1921 Jan 92.88 29,000 70 Bell Telep of Pa 7s 94.60 93.10 80 k Jan 4 20 25 k 80 £1 99.34 96,500 65 k Atlantic Fruit 7s 19 19 3K Nov 550 ik 2k 10 9 Feb Sept K Subsidiaries OMay 70 79 1 2,500 65 Former Standard oh Anglo-Amer oil.r Buckeye Pipe Line.r.._50 Eureka Pipe Line.r 100 Galena Sig Oil com.r..100 79 95.00 95.42 Jan 90.40 Apr 91.78 Apr 82.30 May 94.70 May 85.16 86.10 196,000 small do 86. 100.00 1,200 High. Nov 27 1 ik 2k Second preferred_r__ 100 World Film 2d pref.r._ Low. 1,925 K ik k k 10 6 Jan 8k 37 89.80 90.10 $16,650 85.90 85.90 1,500 u 8 Steamship 50 k 108k Range since Jan. 1. Shares ik 1H 20,069 1st Lib Loan 4s. 1932 47 4kb1932-47 2d Lib Loan 4kb 1927-42 3d Lib Loan 4^8... 1928 4th Lib l'n 4ks.1933-38 Victory 4kb 1922-23 Allegheny Vail gen 4s. 1942 29 k 1 23 163 2d Lib Loan 4s..19 7 42 1st Lib Loan High. Feb Aug * for Week. Low. 29 36 47 Price. 29 k Bonds— u s Lib Loan 3ks-1932 (Concluded) Par of Prices. V 8 Distributing com.r.50 30 31 Stock* Week's Range 1 13,050 1,890 IK Tonopah Mining Union Last Sale. Range since Jan. 1. Last Sale. Salts Friday Sales Friday Stock* [Vol. 111. CHRONICLE THE 3416 ik 1 ik 7,800 3,500 4 6komay 2k 4k 135' Nov Dec Dec 7 k May k Aug 15-16 4c Dec Dec 300 12 k ik Nov Apr Jan Feb 1 3-16 Jan ik 12c Oct Jan 1-16 Mar k Jan Nov ik Sept k lc 2,000 lc 4c 6c 16,600 2c 3k 4k 3,300 Jan 4KcMar lc ""5c Jan 3k Oct 14c Jan Jan 80c Mar Dec 8k Jan Dec. 18 Sales Friday Last Week's Ranee ef Prices. Low. High. New York City Realty and Surety Range since Jan. 1. for Sale. Mining (Conduced)—Par Week. Price. 3417 CHRONICLE THE 1920.] All prices dollars per High. Low. Shares. l 3-16 2c lc Sutherland Dlvlde.r— 1 Tonopah Belmont Dev...1 Tonopah Dlvlde.r ] Dec 7c Jan HcJune 12,800 2c 1 7-16 1 5-16 IX 1,982 IX 1 1-16 IX 19,750 1 5-16 17-16 2,760 Tonopah Extension 1 Tonopah Mining.r l IX 1X IX 7c Jan 2 7-16 2 5-16 2H 11,670 X 4Xc X 2,000 United Mines of Mexico U S Continental MlnSa.r.l Victory Dlvlde.r __iOc 4c 4Hc 3X Jan Aug 4X Jan 2 15-16 1 5-16 June July 3X Dec Dec AX X 6,000 4c 4c lie 10c lc lc lc 7,000 10c 6e 5Hc 7c 23,500 l lc lc 2c 16,700 lc IX IX * 5 Allied Pack X 7,545 dehOs r'39 8c 95 X 91 IX Mar Oct 12o Jan 50X Sept 98 X Jan 95 Nov 90 H Nov 96 X 93 Nov 21,000 91 Nov "93 H 93X 94X 89,000 92 X Aug 97 H Jan 1924 92 H 91X 93 60,000 96 X Jan 89 X 89 X 91 214,000 91X 89 X Dec Anaconda Cop Min 7s_r'29 6% notes Ser A ...1929 Dec 9ex* Oct 80 82 X 0% notes. Anglo-Amer Oil 7Ha r.'29 Armour A Co7% notes r'30 99 X 31,000 94 X 93X 95 X 105,000 95 Bergen (City of) Norw8s, '45 Beth Steel Eq 7s.r 1935 98X 95 ~94X "100 X 101 93 X Dec 98 Oct 94 Dec 98 Nov 94 X 10,000 90,000 95X Nov 26,000 86 62,000 99 X Sept 99 X 475,000 99 92 86 Canadian Nat Rys 7s. 1933 I Can Northern Ry 7s. 1933 Columbia Graph Mfg 8s '25 Aug 98 Jan Mar 88 94 X Brazilian L & Tr 6s 98 X Dec 80 67,000 "99 X 5,000 89 100 X 100 99 89 94 Oct Dec 91 Dec Nov Dec 102 x 100 X Nov Dec 99 X Aug Dec 100 Cons Gas of N Y 8s_._1921 98 X 97H 100 890,000 97 X Dec Cons Textile deb 7s —1923 Denmark (Klngd of)8s.l945 93 X 92 94 46,000 92 Dec \7% 97. 97 X 140,000 97 Dec 10,000 100 Nov 100 X Oct Oct 90X Oct Dec 85* Nov 97 X June Oct 101 Diamond Match 7Hs.r '35 Duquesne Light 6s... 1949 100 87 87 5,000 Empire Gas A Fuel 6s.r_'24 83 83 5,000 41 72,000 40 Nov 62 June 50 15,000 50 Nov 77 July 59 59 10,000 59- Dec 59 Dec 93 X 93 X 22,000 93 80 86 94 94H ~07 66 70 89 89 91 19,000 86 86 SQ 26,000 French Govt 4s_r :;v4i'-v :MS0^ 41 French Govt 5s.r_ French Govt 6s.r Galena-Signal Oil 7s.r.l930 Goodrich (BP) Co 7s. 1926 83 X Heinz (H J) Co 7s_r__1930 Interboro R T 7s.r._.1921 Kennecott Copper 7sr. 1930 Laclede Gas Light 7s.r Lorlllard (P) 8s Lukens Steel 8s.r 85X 83 3X Nov X 99 Dec Apr 80 f 95 Nov Aug 76 Jan 89 Dec 86 Dec 98 X 94 X Nov Dec 100 X Dec Dec 170,000 Dec 56 X 15,000 Dec 94 108,000 lUU'j UCi Dec 98X Aut 1,000 2,000 100 h 100 x 100h _ 100 X 100 X 95 X Jan 1940 99 X Morris A Co 7Hs.r_.1930 Nat Cloak A Suit 8s_r 1930 95 X 96 2,000 99 X 100 40,000 95 Sept 1 0 Of National Leather 8s.r 99 H 99 X 99 X 55,000 99 X Nov 100 D"c N Y N H A Hart 4s.r 1922 60 50 62 83,000 50 Dec 84 Oct Norway. Klngd of, 8s r '40 Ohio Cities Gas 7s.r..l921 99 X 99 X 99 X 120,000 99 X Dec 1924 92 92 92 90 92 X 92 Dec 92 Nov 10,000 13,<*)0 92 93 X Sept June 90 Dec 96X June wiX Dec 94X 9X Dec 38 Pan Amer Petrol A Tr 7s'20 Russian Govt 5Hs_r_1921 9X X 18,000 380,000 10 .. 97 •'.: Sept 400 420 •82 84 Cbesebrough Mfg new...100 190 100 100 50 ♦27 Cumberland Pipe Line 100 ♦125 Eureka Pipe Line Co 85 100 44 Galena Signal OH com...100 29 Preferred new Continental OH Chic St Louis a n o 5s 7-50 Chicago a n w 4h8- 92 96 Chicago ria Pac 4ha, 5s.. 7.00 0.35 7.75 6.76 153 158 Colorado a Southern 5s 8 00 7.00 8.00 7 50 6.76 7.00 6.35 163 90 Solar Refining.. 38 Louisville a NashvHle 5s 7 00 6.35 480 200 6 -87 7.50 6.25 195 Michigan Central 5s, 6s Minn St p a s 8 m 4xe 350 375 100 Missouri Kansas a Texas 6s. 8.25 7.25 235 240 Missouri Pacific 5s. 8.00 7.00 Southwest Pa Pipe Lines. 100 58 62 7.50 6.76 310 315 7.15 6.50 Standard OH (California) .100 70 Norfolk a Western 4ha 6.90 0.25 600 Northern Pacific 7s 7.12 6.40 Standard Oil (Kentucky) 100 425 450 Pacific Fruit Express 7s 6.87 6.40 Standard OH (Nebraska) .100 410 430 6.87 0.35 Standard OH of New Jer.100 600 610 103 104 6.87 6.89 6.35 100 Pennsylvania rr 4 h a Equipment 4s Plttsb a Lake Erie 6X Standard OH of New Y'k.100 335 345 Reading Co 4hs 6.90 6.37 Standard Oil (Ohio) 100 405 420 St Louis Iron Mt a Sou 5a. 8.00 7.00 Preferred 100 102 105 St Louis a San Francisco 5s 8.00 7.6« Swan A Finch 100 45 60 Seaboard Air Line 5s 8.00 Union Tank Car Co 100 100 100 104 94 97 100 280 290 10 ♦30 35 .. Preferred Preferred Washington OH 86 Dec- 91X 92 X 17,000 91X Dec wStandard Oil (Calif) 7sr'31 wStand Oil of N Y 7s.r.'25 Bwedlsh Gov 6s June 15 '39 iod" 99 X 100 X 319,000 99 X Dec 6.80 035 Virginian Ry 6s 7.60 6.75 Public Utilities Oct Tobacco Par Bid Ask. Jan v85 90 Dec American Cigar common. 100 Preferred 10< 80 83 160 Araer Machine A Fdry__100 Jan American Tobaooo scrip 96 *1114 12 8,000 97X Nov 7X Nov Brit Amer Tobac, bearer.£1 *1138 m 85,000 79 X Dec Jan Conley FoU (new)...no par *11 13 99 X May 101X Oct 95X Dec 99 X Apr Helme (Geo W) Co, 00m .100 150 160 100 89 93 97 X 79 X SOX 97% 97 X 97 X 280,000 16,000 97X June 37,000 93 Aug July 95 X 96 20,000 OCX 95 X 97 98 X 80.000 96 X Preferred 8 *73s German Government and Imperial Tob of G B A Ire Johnson Tin Foil A Met. lOf 95 110 MacAndrews A Forbes.. 10( Dec 100 110 100 78 84 Porto Rioan-Amer Tob.. 100 90 100 Preferred Marks 16 H 150,000 16 X Aug 12H 157,000 12 Dec Oct 27 12 28 June 4Hs.r 13 13 75,000 13 Dec 29 H June 4s.r 12 13 7,000 12 Dec 29 X June 12 12 5,000 12 Dec 27 June 4Hs.r Frankfort 48—........... 80 90 25 *80 87 25 100 *30 33 97 100 87 92 150 160 Scrip Reynolds (R J) Tobacco. B common stock Preferred Tobacco Prod Corp scrip 31 *June Dec 31 June Weyman-Bruton Go, 00m 100 Preferred -100 12 13 10,000 12 Dec June Young (J 8) Co 13 13 2,000 13 Sent 27 x 28 X 14X 85,000 9X ..... Nov 14 10,000 9X 14X 14X German Govt 4s.r 9X June Rubber value. 92 142 85 90 Stocks the Stock 84 Firestone Tire A Rub,com. 10 100 7% preferred 100 Gen'l Tire A Rub, 00m...100 % Dollars per 1,000 lire, flat, as prospect. J Listed where additional transactions will be found, o New stock, issued, z Ex-dividend, y Ex-rights, z Ex-stock dividend. par 1 Listed 88 135 10( —100 Preferred a on 6% preferred... 82 __ 75 300 400 100 80 I 90 Goodyear Tire A R, com. 100 k Correction. 26 27 Preferred New York City Banks and Trust Companies All price* dollars share. per Bid Atk Banks Bid Ask Trust Co's America • 190 200 Industrial*... 190 205 New York Amer 240 250 Irving Nat of Exeb_. Atlantic 215 Battery Park. 170 Bowery* 450 mmmm 180 | ny Liberty ...100 100 Mohawk Rubber Banks—N Y I 5312 Preferred Miller Rubber Bid Ask 90 100 55 '7434 20 Portage Rubber, com Preferred 221? 208 215 Bankers Trust 327 333 330 340 Central Union 325 335 50 r Cent 195 202 Columbia 296 305 Am Cot OH 6s 1924..MAS2 88i2 150 ieo Meoh a Met. 302 310 Commercial.. 140 150 Amer Tel A Tel 6s 1924.FAA Boro*. 105 125 Mutual* 490 Empire 300 9u2 9278 145 165 Nat American 150 Equitable Tr. 280 290 Park* 145 nat city 304 New 309 Farm l a Tr. 330 840 Butch a Drov 32 30 Neth*„ 160 170 Fidelity Inter. 200 210 195 205 ;New York Co 135 145 Fulton 260 270 Chase 320 330 New 460 480 Guaranty Tr. 295 305 Chat a Pken. 245 255 Pacific » 160 Hudson 165 165 Chelsea Exoh* 125 145 Park 430 440 Law Tit a Tr 110 120 Anglo Amer OH 7 Xs '25 AAO Arm'rACo7sJuly 15*30 JAJ 15 Chemical 535 545 Public 225 255 Lincoln Trust 156 165 Beth St 7s July 15 245 Republic* Bryant Coal a Iron.. 165 235 Colonial*— 350 Columbia*... 150 Commerce- 210 Oomm'i York mm mm 110 210 ..mmm- Common¬ 210 wealth* 7s 1929 Series B JAJ '22.JAJ 15 Mercantile Tr 280 306 7% notes July 15 *23 JAJ15 Seaboard • 600 625 Metropolitan. 240 250 21 33 Cities Service Co com...10< 251 254 64 65 Preferred ..........„.1cx Colorado Power com 450 460 Mutual (West¬ 210 225 State*... 200 Tradesmen's* 200 220 Union Exch— 170 chester) ■ m 105 125 n y Life Ins. mm mm a mmm Trust n y Trust... 176 490 510 690 615 Continental.. 130 United States* 155 165 Title Gu a Tr 285 295 Corn Exch*.. 318 328 Wash h'ts*__ 350 425 u s Mtg a Tr 390 400 Cosmop'tan*. 110 120 YorkvUle* 375 425 United 810 Cuba (Bk of). 140 160 East River—. 170 • mmm 9912100 09 '2 100 79i2 80?4 89'4 89^ 9834 99i2 94'2 95 97 9734 Brooklyn States Brooklyn Brooklyn Tr. 830 94 ! 1923-MAN15 86 Lehigh Pow Sec 6s 1927.FA A LlggettAMyersTob6s'21 JAD Penn Co 4Ha 1921...JAD15 Pub Ser Corp N J 7s '22.MAS 8 48 75 80 11 13 58. 62* 74h 75»4 6 10 20 30 44 78 74 70 75 66 70 77 78i2 141? 17 64 68 6 8 18 Tennessee Ry l a p com. Preferred preferred Western Power Corp 98 1u2 33 6( 5( *101? 10< 10< lOf 10( 10( h\ *30 l uj!1 18 50 3 | 22 , 52 17'2! 181$ 59 10( Preferred 8712 94 10' Preferred 21 86 10' com..10' ... Preferred 61 Industrial and Miscellaneous—Pe r shar e 165 100 161 American Chicle com.no par 27 .100 62 64 100 133 136 Typefounders com. 100 38 41 American Brass Preferred American Hardware Amer 2784 100 w) Co, new Preferred 83 85 90 93 68 70 Celluloid 94 95 94i2 83 •22 127 •50 60 83 du Pont (e i) de Nemours 93 80 1 50 Preferred 88 15 5 44 10' Standard Gas a el (Del). buss (e Laclede Gas 7s Jan 1929 FAA Nov 84 10' South Calif Edison 1st 33 79 Light—.10' Republic Ry a Light Preferred 12 32 ... 93 92 6s "9" ... 9434 MAN Goodrich (B F) Co 7s '25 AAO Hocking Valley 6s 1924MAS Interboro R T 7s 1921 MAS K C Term Ry 4Ha 1921.JAJ Federal Sug Rfg 6s 1924 82 Preferred 10' Com'w'th Pow Ry a Lt—10* Preferred. 10' Elec Bond a Share pref—10< Federal Light a Traction 10' Preferred 10' Great West Pow 5s 1946. ja.' Mississippi Riv Pow com. 10' Preferred 10' First Mtge 6s 1951—-ja. Northern Ohio Elec Corp. (t Preferred 10' North'n States Pow com. 10' Preferred 10' North Texas Elec Co 00m 10' Preferred 10' Pacific Gas a Elec 1st pref 10( Puget Sd Pow a Preferred 11 »10 10' 99^100 Canadian Pac 6s 1924.MAS2 Second 23d Ward*... — Ex*. mmrn-rn MAN MAN 7% notes 1922 7% notes 1923 AnacondaCop Mln 6s'29.JAJ 92 10 18 30 9314 Bronx Nat-.. 6% notes 1922 A AO Am Tob 7% notes 1921MAN 50 62 n 10' 89i2 Broadway Cen Gent Meroan. 45 United Lt a Rya com Bronx Manhattan *. a Lt com...10' ...10' Public UtUltles com 10< Preferred 70 60 -100 Preferred Short Term Securities—Pe 78 Carolina Pow a Light com 10< 50 Swlnehart Tire A R,oom_100 American Preferred Amer 100 100 94 76 com Preferred "99" British Amer Tobac ord__£l 36 92 Trac Amer Power Dec Dec 99 *34 10' 10' Preferred Amer Lt a *97 5( 5< Amer Gas a Elec com... Sh are. Stocks—Per Oct 97 97H 6.75 7-60 8.75 Union Pacific 7s 97 X 79 X 6.40 7.50 144 Dec 97X 6.85 Equipment 7s Southern Railway 4Hb..— 0.40 100 Dec 93 X 6.95 4ha. 350 25 *90 100 325 ...50 *142 < 1921 Dresden Southern Pacific Co 6.75 77'4 Switzerland Govt SHs.1929 7 12 8.00 7.12 Equipment 4 ha 7-50 £0 100 20,000 38,000 6.40 Toledo a Ohio Central 4s.. Other Oil Stocks 99 94 ... Equipment 5s 93 16H 7.00 *68 34,000 12X 7.75 580 $25 par value stock 82,000 78 X 7.10 6.40 Standard OH (Kansas).-.100 240,000 100 X .. n y Ontario a West 4Hb.— 99X Badische Anil Soda 4Hs— Berlin 4s.r New York Cent 4ha. 5s Equipment 7s New stock 94 X 77 X ... Mobile a Ohio 4x, 5s Standard OH (Indiana)-.100 X UjOX 100 X 7.37 6.50 Equipment 5s a 7s 97 ....100 South Penn OH 88 X 99 96 6.75 Southern Pipe Line Co.. 100 93 Municipal Bond* (Dollars per 1,000 Marls) 7 37 6.60 *35 460 100 ..100 Prairie Pipe Line 88 X Apr 7.00 6.35 6.75 6.40 ... 25 94 98 X 7.00 Kanawha a Michigan 4ha.. July 98 — Equipment 4hs Equipment 7s 95 287 5s 100 Prairie OH A Gas BinclairConOll7Hsr._. '25 Bolvay A Cie 8s.r.... 1927 Southern Ry 6% notes 1922 When 46 93 .100 Penn Mex Fuel Co Imperial OH w 6.75 6.50 8.50 7.50 97 158 Magnolia Petroleum Midwest Refining.. Unlisted, 7.50 25 *283 Oct r 7.50 95 135 New York Transit Co...100 Oct f No 6 50 8.50 25 Oct this week, 7.10 - *23 98 X lots, 6.40 Equipment 6s..Chicago a Alton 4x9, 5s — Chicago a Eastern iu 5Hb— Cblc Ind a Loulsv 4ha National Transit Co...12.50 99 X •Odd Chesapeake a Ohio 0hs~6.75 111 Hocking Valley 4Hs, 5s Illinois Central 5s 64 Exchange 100 Erie 4X, Nov Hamburg 4 Ha.r Leipziv 4'Xs.r 97 108 16*4 Nov Cologne 6.87 *1612 Dec Bremen 7.50 International Petrol,(no Par) Ohio OH Co 6.40 7.00 Central of Georgia 4hs 85 Northern Pipe Line Co. 6.37 205 *83 ""X "97X 6.35 « 100 50 93 x 6.35 6.95 6.90 Canadian Pacific 4hs a 6s7.37 100 new Indiana Pipe Line Co 93 Va-Caro Chem 7Hs.r.l932 Western Elec conv 7s.r.*25 6.75 6.95 Preferred Illinois Pipe Line... 66,000 Dec 7 60 Equipment 4s Equipment 6s 7.75 /. 100 X c^.l Basis. Buff Rooh a Pittsburgh 4xs 100 47,000 91 160 Baltimore a Ohio 4hb._—— Preferred old. 94 X 77X 85 150 Carol Cllnchfleld a Ohio 5s.. Crescent Pipe Line Co 97X Aug rr. Equipments—Per 18 Co 100 Buckeye Pipe Line Co... 50 Borne Scrymser Vacuum OH Nov ■' Ask. 105 46 H s ♦1712 102 X 1925 75 "and Interest" except where marked *'f.' 100 Preferred 93 99 H 100 160 a 1000 97 100 150 West a Bron* 950 40 X Texas Co 7% notes, r. 1923 Union Tank Car eq 78.1930 u 8 Casualty. us Title Guar 120 Bid. Par 94 X 6s. r 192 110 Per shar Anglo American Oil new. £1 Atlantic Refining.... 100 97 X 100 186 Title y Mortgage.. Standard Oil Stocks 45 100 n Quotations for Sundry Securities Bears,Roebuck A Co 7s r'21 7% ser notes.r.Oct 15 '22 7% ser notes.r-Oct 15 '23 Swift A Co 7s.r Surety.. Nat All bond prices are Seaboard Air Line 6s 99 X 106 Assoc Realty Title a m g Feb 92 1926 7s_r 98 X 97 X 92 1923 7«.r. Oct Oct 1,000 92 97X 94 5,000 92 7s.r t>t 3,000 98 95 1922 10 .h 2,000 98 95 7s.r 85 Apr 5,000 95 Aluminum Mfrs 7s.r Amer Light & Tr 6s.r.l925 Amer Tel 4 Tel 6a.r—1922 53 65 75 Jan 20o (Dec X 225,000 51X 51X 196 67 Preferred Jan $ conv 190 City Investing ■ 1,200 Bonds— 100 Mtge 2 7-16 Jan lc May 5Xo Dec Yukon Gold Co.r.*. Ask (Brooklyn). Lawyers Mtge 70 Apr 29o July Dec White Caps Exten White Caps Mining Wilbert Mining H Bid 80 80 65 Jan Nov 6 15-16 Ask 115 75 70 Amer Surety. Bond A M G. Jan Aug X West End Consol'd l Rid 108 Alliance R'lty Jan 2X 1 y 21,400 AXc H 5c Aug I 3-16 1 2,200 Mining..1 United Eastern 1 7-16 Jan X Nov X lo 11,870 2c ; lc IHc 4,400 3-16 3-16 1 Bond.. Ask Bid Standard Silver-Lead Success Mining Companies. share. 6412 65'2 97u 9834 82 100 80 82 .100 140 150 ..100 Preferred Company 161 165 100 76 78 100 1 100 4 6 1st g 5s June 1 1922. .jad Intercontinen Rubb com. 100 f45 56 International Salt 561? /68 a Co, 00m Debenture stock Havana Tobacco Co. 9734 98 100 Borden Company com Preferred 7 hi 9 Coney Island* 140 155 480 600 Fifth 150 165 First 205 215 Hamilton 260 270 First. 920 940 Green point— 160 180 630 660 Reyn (R J) Tob 6s '22.FAA Sloes Sbeff 8 A I 6s '29-FAA Garfield 220 230 Homestead*.. 80 100 Kings County Manufacturers 195 203 Southern Ry 6s 1922...MAS 92 9234 International Sliver pref. 100 ♦85 Gotham—... 190 205 Mechanics'*— 85 92 People's 275 290 Swift A Co 6s 1921...FAA15 97i2 98 Lehigh Valley Coal Sales. 74 250 Montauk* 85 95 93 931? 60 100 Royal Baking Pow com.. 100 *70 Greenwich *.. Phelps Dodge Corp 160 175 105 110 100 x78 80 Singer Manufacturing—100 Singer Mfg Ltd £1 147 151 Fifth Avenue* 910 930 « .* «« Hanover 795 810 Nassau 225 Barrlman 3-50 360 North Side*.. 195 205 Imp a Trad.. 505 515 People's RJdgewood— 150 7% notes Oct 15 '25 AAOI5 100 • Banks marked with «h!s week. (•) I New stock. Texas Co 7s 1923 rnrnmrn | 200 State banks, t Sale at auction or at Stock Exchange « Ex-dividend, s Ex-rights. are MAS -£>614 "9634 85 97i2 87 98 U S Rubber 7X* 1930—FAA 97 80 82 West Elec conv 7s 1925. A AO 98 9834 Preferred 9734 Utah Sec Corp 6s '22.MAS 15 1st gold 5s • 6 Basis. Per share. /Flat price. ■ Nominal. Ex-dlvldend. aao *284 mmmm 71*1 90 3u accrued dividend « New stock. » Ex-rights. v Ex-50% stk. dlv. 4 Purchaser also pays » 1951 100 2418 [ttucstwcut aiul ItaxXrcrail RAILROAD GROSS EARNINGS The earnings of various ST GAM roads from whioh regular weekly or monthly returns .ran be obtained. The first two columns of figures give the gross earnings for the latest week or month, and the last two columns the earnings for the period from Jan. 1 to and including the latest week or month. The returns of the electric railways %te brought together separately on a subsequent page. I following table shows the gross Latest Gross Earnings. ROADS. Week or Month. Latest Gross Earnings. Jan. 1 to Latest Date. Current Previous Current Prevoius Year. Year. Year. Year. Alabama. & Vicksb . — October 332,685 247,273 2,869,816 2,287,577 - October 328.564 277,564 4,153,364 3,906,677 6,395,511 5,539,216 59,866,284 51,815,734 25015394 18917768 187589266 151527692 239,443 1,814,512 281,168 1,658,242 671,776 482,540 5,450,151 4,204,215 13,559 10,499 100,120 85,255 Belt By of Chicago. October 556,647 389,627 3,739,607 3,111,865 Bessemer Sc L Erie.. October 2,156,030 1,244,327 12,660,178 11,226,250 39,232 163,777 1,333,766 1,010,966 Bingham & Garfield October 63,098 47,672 520,878 480,310 Birmingham South- October Boston Sc Maine..-. October 8,713,545 7,224,195 71,722.728 59,675,321 130,539 98,363 969,659 854,158 Brooklyn E D Term October Buff Roch & Pittsb. 1st wk Dec 465,483 312,847 21,576,515 14,128,433 October Buffalo A Susq 335,927 245,034 2,515,210 1,941,829 Canadian Nat Rys. 1st wk Dec 2,678,306 2,050,134 101563465 87,174,673 Canadian Pacific... 1st wk Dec 5,215,000 3.797,000 190108000 153865000 Can Pac Lines in Me October 220,570 176,490 2,312,338 2,189,933 Caro Clinch & Ohio. October 789,394 571,717 6,124,904 5,168,798 Central of Georgia. October 2,246,462 1,952,520 21,135,712 17,690.512 Central RR of N J_.(October 5,650,965 4,077,471 41,836,692 36,973,106 Cent New England. October 900,117 765,560 6,025,184 5,617,335 Central Vermont...'October 559,887 5,913,471 725,475 4,827,338 Charleston Sc. W Car October 300,328 296,008 2,869,512 2.507.730 10075590 6,771,577 73,044,113 60,445,039 Ches & Ohio Lines.. October 3,112,400 2,429,236 24,675,201 21,120,093 Chicago Sc Alton... October 18919313 16281562 151668275 128485759 ChlC Burl Sc Quincy. Octoberl 3,198,029 2,583,423 24,893,896 20,942,490 Chicago Sc East 111.. October 2,426,957 2,246,305 19,799,260 18,354,865 Chicago Great West October Chic Ind & Louisv.. October 1,643,681 1,295,341 13,150,147 10,274,609 387,193 358,786 2,852,242 3,056,317 Chicago Junction.. October Chic Milw Sc St Paul October 17499(474 14798636 138776613 125060892 17739415 14252588 136952506 116365240 Chic Sc North West- October Chic Peoria & St L. October 286,947 231,919 2,273,328 1,453,415 13199480 11372558 112620286 91,777,948 Chic RI & Pacific.. October Chic R I & Gulf.. October 683,752 572,534 5,482,458 4.042,612 Chic St P M & Om. October 3,184,708 2,818,819 26,282,971 22,682,130 Chic Terre H & S E. October 716,932 532,395 4,847,536 3,600,532 Cine Ind & Western October 417,486 307.126 3,699,177 2,563,301 656.670 Colo & Southern... 1st wk Dec 497,865 28,951,661 23,800,353 > Ft W & Den City October 1,330,621 1,059,220 10,542,919 9,089,144 Trin Sc Brazos Val October 303.671 146,812 1,690,147 1,105,615 Wichita Valley... October 172,192 159,748 1,420,013 910,952 Colo & Wyoming—. October 876.724 57,282 107,619 837,889 116,710 97,687 814,618 845,860 Copper Range..... October Cuba Railroad September 1,194,589 11094,970 9.257.083 8,388,647 140.629 Camaguey & Nuev September 143.127 2.326.084 2,072,289 Delaware Sc Hudson October 4,219,250 3,354,154 35,734,658 28;997,866 Del Lack & Western October 8,836,825 6,401,622 64,840,464 59,376,607 Deny Sc Rio Grande October 4,055,959 3,477,549 32,090,329 27,020,629 Denver & Salt Lake October 349,649 292,153 2,371,081 2.396.731 Detroit & Mackinac October 247,274 196.524 1,723,348 1,380,352 Detroit Tol Sc Iront. October 598,053 430,830 4,230,907 3,149,024 Det & Tol Shore L. October 214,027 225,198 1,589,484 2,044,421 Dul Sc Iron Range.. October 1,414,918 603,653 10,065,045 7,397,771 Dul Missabe Sc Nor. October 2,819,900 2,229,239 17,813,621 18,698,783 Dul Sou Shore & Atl 1st wk Dee 113,988 67,845 5,457,376 4,425,921 Duluth Winn Sc Pac October 269,609 176,270 2,033,012 1,588,630 East St Louis Conn. October 157,832 109,587 1,202,569 1,009,936 2,809,343 1,151,891 20,279,448 16,128,294 Elgin Joliet Sc East. October El Paso Sc Sou West October 1,399,749 1,168,006 11,949,886 10,460,981 Erie Railroad October 11579587 8,751,988 87,664,561 76,050,004 Chicago Sc Erie.. October 1,499,825 954,229 10,490,954 8.620.445 N J Sc N Y RR... October 133,253 102,969 937,212 1,102,335 Florida East Coast. October 1,078,116 812,119 10,959,368 8,260,140 Fonda Johns Sc Glov October 123,049 102,589 1,192,659 1,042,374 Ft Smith Sc Western October 252,573 209,552 1,600,972 1,340.391 Galveston Wharf... October 256,604 726,766 101,989 1,484,109 Georgia Railroad... October 662,870 723,781 5,535,072 5,177,735 Georgia Sc Florida.. October 162,905 91,636 1,251,063 818,535 Grand Trunk Syst— 4th wkNov 3,086,777 2,352.615 Atl Sc St Lawrence October 333.339 213,091 2",485"580 2.538" 128 OhDetCanGTJct October 213,034 1,535,038 1,761,178 148,794 Det G H Sc Milw. October 440,541 518,560 4,004,149 3,677,046 Grand Trk West October 1,727,088 1,275,346 14,368203 11,491,544 Great North System October 13261977 11790299 102049090 89.025,304 Green Bay & West. October 132,208 135,403 1,050,083 1,007,439 Gulf Mobile & Nor. October 461,075 306,827 3,276,222 2,298,000 Gulf Sc Ship Island. October 223.412 326,073 2,525,124 2,021,332 Hocking Valley.... October 2,131,704 1,418,374 13,702.047 10.001,359 Illinois Central.... October 14671029 10774863 118706595 89,670,631 Illinois Terminal October 115,079 788,160 90,033 887,432 Internat Sc Grt Nor. October 2,442,224 1,364,461 15,757,190 11,742,020 Kan City Mex & Or October 148,593 1,137,714 178,849 1,378,071 K C Mex & O of Tex October 221,944 145,091 972,009 1,558,628 Kansas City South. October 2,126,779 1,463,259 16,190,922 12,360,549 Texark Sc Ft Sm. October 255,349 163,624 1,762,657 1,234,948 Kansas City Term. October 165,345 146,045 1,327,192 1,156,457 Kan Okla & Gulf... October 313,894 211.767 2,168,011 1,232,474 Lake Sup Sc Ishpem. October 204,543 97,442 1,520,067 920,784 Lake Term Ry 150,373 93,372 1,141,834 930,184 October Lehigh & Hud River October 364,533 309,462 2,460,422 2,256,903 Lehigh & New Eng. October 566,422 449,423 3.796,112 3,219,201 Lehigh Valley 8,486,513 6,210,026 60,202,479 53,379,837 October Los Ang Sc Salt Lake October 1,930,409 1,577,112 16,871,749 14,080,585 Louisiana & Arkan. October 401,291 178,348 3,464,236 1,712,103 Louisiana Ry & Nav October 459,170 328,597 3,506,563 2,911,687 Louisville Sc Nashv. October 11592764 10450909 103636597 89,043,902 Louisv Hend Sc St L October 300,356 280,294 2,598,201 2,445,883 Maine Central..... October 2.239,932 1,594,679 17,220,614 14,447,154 Midland Valley.... October 511,965 391.768 4,061,555 3,269,221 Mineral Range. 1st wk Dec 9,913 12,539 640,792 708,999 Minneap & St Louis 1st wk Dec 404.234 227,914 15,940,033 12,511,061 Minn St P Sc S S M. October 5,382,988 4,483,018 39,357,891 35,162,854 126,984 Mississippi Central. October 103,975 904,147 843,511 Atlantic City Atlantic Coast LineBaltimore Sc Ohio.. B & O Ch Term.. October October October Bangor Sc. Aroostook October Bellefonte Central.. October _ .— . . ... _ AGGREGATE OT GROSS Current 4th 1st 2d 3d Weekly Summaries. Sept week week Oct week Oct week Oct 4th week Oct 1st week Nov 2d week 3d week 4th week 1st week ♦ We Nov Nov Nov Dec no Year. / (13 roads) (13 roads) (15 roads) (18 roads) (20 roads) (20 roads) (19 roads) (20 roads) (19 roads) (16 roads) - Previous Year. $ * $ . Increase 19,550,180 17,548,585 18,221,855 19,594,760 27,081,898 19,138,392 18.754,798 18,862.044 24,998,832 15,925,478 13.253.628 13,670,975 14,822,387 21.930.629 14,230,219 14,264,410 14,919,321 19,207.734 15.876.023 12,573.390 Year. Year. Missouri Kan Sc Tex October 3,970,639 3,235,979 32,951,581 2.725,980 2,429,787 20.020.665 220,006 162,936 1,708,545 Missouri Pacific.... October 11715985 9,398,504 95,660,483 October 368,731 3,460,398 Monongahela 545,893 272,967 198,814 2,603,617 Monongahela Conn. October Montour October 224,391 165,111 1,308,530 Nashv Chat Sc St L. October 2,307,002 1,858.640 20.415,596 Nevada Northern. October 78,867 158,679 1,430,475 8,946 6,285 381.650 Nevada-Cal-Oregon 1st wk Dec 19.435 11,469,560 Newburgh & Sou Sh October 211,148 New Orl Great Nor. October 266.218 191,846 2,233,281 N O Texas & Mex.. October 332,247 229,789 2,401,380 Beaum S L& W„ October 1,818.769 234,092 134,376 St L Brownsv &M October 746,439 537,216 6.287,055 Octooer New York Central. 38219521 29205871 302245348 Ind Harbor Beit- October 1,126,767 644,338 7,480,658 Lake Erie A West October 1,134,863 995,284 9.612,857 9,106,911 7,819,647 72,691,226 Michigan Central October ClevGC&St L— October 8.989.923 7,468,981 73,440,786 October Cincinnati North 447,097 268,544 3,044,449 Pitts Sc Lake Erie October 4,655,112 2,286,073 27,630.835 Tol Sc Ohio Cent. October 1,544,746 1,018,873 10,591,491 Kanawha & Mich October 577,427 477,400 4,325,116 N Y Chic & St Louis October 2,492,529 1,957,582 22,979,249 Mo K AT Ry of Tex September „ .... _ . . N YNH & Hartf— October N Y Ont Sc West October 22418216 18602495 173106957 147795463 Pennsylv RR & Co. October Bait Ches & Atl— October Cine Leb Sc Nor. October Grand Rap & Ind October _ Long Island..—. October Mary Del Sc Va_. October N Y Phila & Norf October Tol Peor & West. October W Jersey Sc Seasb October Pitts C C & St L_ October Peoria & Pekin Un. October Pere Marquette Perkiomen October October Phila Beth & N E„ October Phila & Reading. October „ Pittsb Sc Shawmut— October Pitts Shaw Sc North October Pittsb & West Va_. October Port Reading October October Rich Fred & Potom. October Quincy Om & K C— October „ St Jos Sc Grand Isl'd October St Louis-Sah Fran October Ft W & Rio Gran October St L-S F of Texas October St Louis Southwest. October StL&S W of Tex October Total system1st wk Dec St Louis Transfer.. October San Ant Sc AranPass October San Ant Uvalde & G October Seaboard Air Line.. October South Buffalo October Southern Pacific. I October Atlantic SSL nes October _ Arizona Eastern. October Galv Harris & S A October Hous Sc Tex Cent. October Hous E & W Tex. October Louisiana West'n. October Morg La Sc Texas October Texas Sc New Orl. October Southern Railway__ 1st wk Dec Ala Great South. October Cin N O & Tex P. October Georgia Sou & Fla Mobile & OhioNew Orl Sc Nor E. North'n Alabama October 1st wk Dec October October October South Ry in Miss, Spokane Internat.. October Spok PortI Sc Seattle October Staten Island R T__ October Tenn Ala & Georgia 1st wk Dec Tennessee Central-. October TermRRAssn of StL October St L Mer Bdge I October Texas & Pacific,... 1st wk Dec Toledo St L Sc West. October Ulster Sc Delaware. October . _ Union Pacific system Oregon Short Line October 4,529,174 3,145,810 1,286,361 212,550 439,671 October 2,058,217 October 6,282,610 1st wk Dec 460,168 October 1,744,342 October 242,083 October ' 2,032,726 230,737 September October 2,042,009 Ore-Wash RR&N October Union RR (Penn)„ October Utah October Vicks Shrev & Pa October __ Railroad. Wabash RR.....— Western MarylandWestern Pacific.. Western Ry of Ala. Wheel & Lake Erie. _ Wichita Falls&NW Yazoo & Miss Talley +3,624,702 10.25 30.02 +4,550,880 33.28 +4,772,379 28.05 +5.151.569 23.48 +4,908,173 34.49 31.49 +3.942,723 26.43 +5,791,098 30.15 +3.302,633 26.27 +4,490,388 3.951,560 2,825,629 683,211 138,113 325,254 1,363,915 5.185,113 1293,810 1,780,853 213,812 1,324,427 252,745 2,315,003 37,197.148 27,676,513 8,790,473 1,612,594 3,704,544 14,555.288 48,556,405 18,650,724 13,399.769 2,325,270 14,491,915 1,977.831 23,834,664 Current % * Monthly Summaries. Mileage. +4,019.303 19,665.068 October Northwestern Pac_. October Oahu Ry & Land Co September Pacific Coast——— October Virginian 8,111,224 64,737,873 60,561,108 2,425,489 23,594,509 7.869,533 3,681,965 October Northern Pacific October Minn Sc Internat. October Total 330.111 1,067.249 1,914,440 1,660,897 1.103,000 4,506,214 258216642 5,447.281 1,145,641 893,950 10,589,315 9.285,770 490,830 360,072 3,741,635 3.230,886 5,353,564 699,721 666,483 6,544,356 9,336,496 7.459,599 69,019,932 63,482.642 12032973 10703040 91,649.489 83.240,512 109,465 883,061 83,190 1,060,376 802,853 673,861 5,463,239 6,722,210 225,656 1,292,336 114,603 1,620,369 553,404 628,089 60603 431 47112824 456155 874 412147998 167,010 1,360,231 143,724 1,388,746 144,976 141,699 951,778 1,044,027 981,489 812,170 7,881,007 6,834,117 2,325,876 1,854,252 21,805,205 20,902,802 128,533 1,146,273 122,034 1,115.849 741,306 735,792 6,693,888 6,834,622 200,374 1,372,806 169,326 1,677,039 1,349,427 900,029 11,985,623 10,397.484 11636306 8,930,380 87,111.428 77,920,045 158,263 151,131 1,298,562 1,018,199 4,332,742 3,539,290 33,888,564 28,966,321 121,430 913,020 99,137 1.026.709 138,581 689,183 76,336 1,116,762 10583897 7,277,754 74,869,827 61,042,066 209,723 994,737 132,435 1,443.597 180,948 973,211 138,999 1.284.765 291,663 1.145.167 139,347 2,010,264 207,774 194,895 1,541,283 2,097,422 141,137 915,994 103,438 1,114,423 914,261 969,543 9,201,084 10,429,724 607,246 445,546 4,087.634 3.974,858 425,231 280,368 2,849,594 2,451,135 9,412,726 7,662,183 76,911,535 64,363,484 205,907 185,795 1,605,552 1,321,553 187,914 138,792 1,443,928 1,265,353 2,033,979 1,236,245 17,494,977 10,876,734 995,426 663,972 7,590,818 5,457,185 618,354 499,543 30,305,873 20,457,929 133,595 925,180 116,191 1,145,222 813.368 437,229 4,852,855 3,649,245 135,606 909,946 71,283 1,281.385 4,334,067 3,657.284 40,428,691 33,950,086 195,784 830,821 52,820 1,280,551 20860067 1756^996 166400434 139322831 1,094,742 8,520,726 694,766 5.303.766 370,704 362,119 3,369,652 3,077,953 2.974.924 1,917,813 21,252,092 17.540,860 1,373,543 1,023,432 9,620.229 7,584,751 336,012 1,943,634 219,268 2,453,495 508,203 408,315 4,378,567 3,390,485 59,389 767,957 8.475.710 6,333,768 985,986 751,761 8,104,727 6,046.996 3,855,366 3,543,149 159505174 13^821825 1,035,860 939,701 9,482,184 8,489.661 1,879,814 1,382.590 17,211,269 13,295,154 486,889 389,804 4,404,868 3,567,683 365,994 324,631 17,347,580 14,442,890 618,062 530,322 6,390,299 5,311,828 145,030 960.795 118,375 1,250.122 190.797 201,752 1,518,662 1,458,681 140,388 137,041 948,300 1,280,584 927,553 724,015 7,594,078 6,124,342 219,129 182,775 1,984,577 1,897,671 2,104 133,190 4,310 169,888 291,882 219,271 2,099.194 2,449,480 511,368 414,507 3,894,986 3,247,076 507,994 367,391 3,522,204 2,554,056 898,835 821,761 38,567,704 33,420,452 1,118.618 827,617 9,404,873 6,650,029 153,019 140,953 1,249,172 1.032,760 14743231 11825305 108233295 92,571,714 N Y Susa Sc West- Octo jer Norfolk Southern- October „ 1,135,514 16,284,729 1.264,313 12407604 10346762 103107731 87,075444 Norfolk & Western- October Rutland 28,328,571 18 117,970 1,308,023 76.882,429 2,989,540 1,515,524 31,619,028 237604,752 6,523.312 1,003,430 2,733,079 9.992.168 39.912,316 t12655377 11,140,097 2,095,349 10,843,043 1,593,145 20,315,648 EARNINGS—Weekly and Monthly. $ longer include Mexican roads in any of our totals, Previous Year. Mo & North Arkan. October or Decrease. " Current $ Arbor: 1st wk Dec 122,662 113,757 4,870,984 4,164,041 20612086 18025518 176553299 144822598 Atch Topeka & S Pe October Gulf Colo & 8 Fe. October 2,968.629 2,349,412 21,927.617 17,226,312 Panhandle S Fe_. October 914,358 701,129 7,624,251 5,121.281 Atlanta Birm Sc Atl. October 527,620 455,211 4,816,548 4,156,670 Atlanta Sc. West Ft. October 243,216 254,615 2,523,843 2,256,464 — to Latest Date. Previous Year. $ Ann Jan. 1 Current Week or Month. ROADS. Curr.Yr. February 232,210 231,017 212,770 220,918 211,040 208,598 218,918 199.418 224,922 229,935 -231,304 .213,434 April .221,725 May -213.206 June -213.525 July .220,459 August -199.957 September. -226,955 October 231,439 March ... Year. 494,706,125 421.180,870 408.582,467 387,680,982 387,330.487 430.931,483 392,927,365 348,749,787 347,090,277 372,828,115 348.701,414 369.225,761 Increase or Decrease. % Prev.Yr. .2132,511 January Previous Year. t Comparison with 1917 figures, not 1919. +101778760 25.90 +72,431,089 20.77 +61,492,190 17.72 +12,852.867 3.45 +38.629.073 11.08 +61.705,722 16.99 407*351.544 401.376.485 +65.925.059 16-43 441,423,158 367,865,628 +73,557,530 19.98 594.192,321 480,408,546 +113783775 23.68 633,852,568 503,281,630 +130570938 25.94, DEC. 18 1920.] THE 34191 CHRONICLE Latest Gross Earnings by Weeks.—In the table which follows separately the earnings for the first week of December. The table covers for the 10 months aggregating $6,484,736, will be found is last week's "Chronicle"—V. Ill, p. 2327. American Lead Pencil Co.—Capital Increase.— The company has filed notice with the Secretary of State at Albany, N. an increase in capital from $2,200,000 to $3,208,000.—V. 100 p. 644 Y. of American Safety Razor Corp .—British Subsidiary.— A London cable says that the British-American Safety Razor Co., Ltd., capital of £400,000, is issuing an additional £200,000 of stock. It has acquired from an American corporation selling rights of the Ever-Ready , Gem and Star razors for the United Kingdom, Europe, Africa. India and Australia, paying £165,000 in shares of stock of the corporation for the good-will, trade-marks and patents. Compare V. Ill, p. 1945. with a American Stores Co., Philadelphia.—Sales.— 1920. Four weeks to Nov. 27 Eleven months $7,699,944 94,193,908 1919. $6,386,526 68,900,232 Increase. $1,313,526 25,293,676 —V. Ill, p. 2231, 2044. American Tobacco Co.—Dissolution Decree, Etc.— The Federal Trade Commission has recommended to the Department of Justice that because the dissolution decree in the tobacco trust case Is be¬ lieved to have been violated be modified. by the larger tobacco companies, the decree principally recommends: (1) That the provisions of thp declaring the use of common agencies by the various companies named as defendants in the original proceedings relating the use of common agencies in the purchases of leaf tobacco, which expired by limitation Nov. 1915, be revived and made permanent; and (2) That the provision relating to the defendant companies doing busi¬ ness under any other than their own corporate name or that of a subsidiary corporation controlled by them be made specific, so as to include the pur¬ chase of leaf tobacco through agencies not disclosed to the trade. (See also "Jour, of Comm." Dec. 16, p. 2.)—V. Ill, p. 1854. The Commission decree dissolution American Woolen Co .—Stock Syndicate Closed.— announced on Dec. 13 that the syndicate (consisting It was formally Chase Securities Corp., Hayden, Stone & which underwrote the $20,OCX),000 stock of Co. and Brown Bros. & Co.), offered for subscription to the last July has been closed. reported that notices sent to participants in the underwriting, termination of the syndicate, indicated that allotments to subscribers amount to about 97.3% of their subscriptions. If correct, this means that practically the entire issue of $20,000,000 was left in the hjinds stockholders It was announcing the •f the underwriters. offered to the stockholders at par. The underwriters, it is stated, received 5% commission for underwriting the success of the under¬ taking which means that the stock now left in their hands, cost them $95 a share as against the present quotation of about 62%.—V. Ill, p. 1952. The stock was Anglo-American Oil Co.—Petroleum Concession.— according to Washington official advices, has obtained from Government a 50-year petroleum concession for the entire eastern half of the Province of Harrar, Abyssinia, including provisions for a five-year period for prospecting. The terms include a substantial royalty to the Abyssinian Government in the event of production of petroleum.— The company, the Abyssinian V. Ill, p. 387. . official statement issued on or about Dec. 10 says: "Lower prices for live stock which have resulted from declines stuffs and from excessive receipts of stock in all markets have had Influence on the wholesale selling price of all meats, resulting in a prices which are below the prices that obtained April 1 1917, and the prices that ruled in 1914 in many instances. "Fresh beef carcasses were offered to the retail trade at prices in feedmarked level of also below that aver¬ low as in 1914. Light pork cuts, sold for 21 eents as compared with the pre-war price of 22 to 23 cents. Lard was offered at 6 cents a pound under the price April 1 1917, which was 20 cents. The average price of sweet pickled and cured pork products was 17 cents aged between 14 and 15 cents a pound, pricesalmost as pork loins, the price of which is the index of all fresh this morning, that being 3 cents under the "The market value of hides, 14% cents in price of April 1917. the aggregate of the ten grades, dropped 6 cents a pound from the normal price that existed in 1917, and is at this time 1 cent a pound lower than the price that obtained in 1912. Subnormal values of by-products from cattle, of which bides is typical, have had a tendency to hold up the price of fresh beef carcasses, and had the market for the by-products held reasonably stiff, the beef meat prices would have effected further declines by this time." [The permanent notes of the $60,000,000 7% Convertible gold notes dated July 15 1920, are now ready in exchange for temporary interim cer¬ tificates at the Continental & Commercial Trust & Savings Bank, Chicago, •r the Chase National Bank, N. Y. City.]—-V. Ill, p. 2327. 2231. has Associated Oil Co .—Tenders—Regular Dividend.— of San Francisco, trustee, will until noon Jan. i5 receive bids for the sale to it of First Eef. Mtge. 5% gold bonds of 1910, at not exceeding par and int., to an amount sufficient to exhaust $913,900, now in the sinking fund. The regular quarterly dividend of 1%% has been declared on the out¬ standing capital stock, par 8100, payable Jan. 26 1921 to holders of record The Union Trust Co. 1921 Dec. 31 1920.—V. Ill, p. 2327. Atlantic City The company was City Gas Co. Atlantic Coast Co.. Boston.—No Dividend.— directors decided to omit the quarterly dividend usually due in The January on the outstanding $3,000,COO capital stock, par $100. dividends of 2% % have been paid tip to and incl. Oct. 1920. A interest is owned by the Crowell & Thurlow SS. Co.—Y. 110, p. Quarterly controlling 2195. Refineries, Ltd.—Bond Issue Reported.— reports a trust mortgage from the company to the Eastern Trust Co., Ltd., on the property of the company to secure an Issue of bonds to the amount of $3,000,000 under registration date of A commercial agency Compare V. Ill, p. 2231, 2327. Dec. 6. Chemical Co., Atlas Butterick Company.—Enormous Applies in Greater or Less Degree to the In gone Co., Toledo.—Merger, &c.— Ardmore, Pa.—Capital—Sales.— which $4,200,000 was date the stockholders before Aug. 16 to $800,000 ad¬ authorized capital stock is $10,000,000, of Issued and outstanding on July 27 1920. On that were given the right to subscribe on stock at par ($100). or ditional before Sent. 20 and additional issue was paid for by subscribers, making a total paid-in capital as of that date of $4,839,600. The balance of the offering has been duly subscribed and it is expected, will be paid in by Dec. 20, the date for the final payment, bringing the total outstanding up to $5,000,000. Cash dividends of 10% have been paid for several years and for the first six months of 1920 5% was paid (2% % Q.), and it is expected the same rate will be continued. During the first six months of 1920 net factory sales amounted to $5,800,000, compared with $4,100,000 for corresponding period of 1919, an increase of over 40%. The new money derived from the sale of this $800,000 stock will be used for the handling of increasing business, including the manufacture of a new heavy duty model, for which a large demand exists.—V. Ill, p. 1371. 1280. Autosales Corporation. New York*—Earnings — Profit, after taxes, for the nine months ending Sept. 30 1920 is reported $126.636.—V. Ill, p. 2231. 1474. William Black formerly Vice-President, has been elected President, succeeding Charles F. Huhlein who becomes Chairman.—V. 110, p. 2490. "Barrett Company.—Dividend Dates Changed.— of the Preferred stock up to and incl. Dec. 31 1920 to a quarterly dividend on holders of record Dec. 15 1920 of $1 46 per share, payable Jan. 3 1921. The quarterly dates upon which the dividends of the Pref. stock shall be paid in the future shall be changed from Jan. 15, April 15, July 15 and Oct. 15 to Jan. 1, April 1, Ill, p. 2142, 1371. July 1 and Oct. 1.—V. Bell Telephone of Pennsylvania.—Bonds Approved The stockholders have — approved the plan creating a 1st & Ref.Mtge.of $150,000,000 under which will be issued the $25,000,000 7% 25-year bonds recently offered and sold. Compare V. Ill, p. 1372, 1474. Black & Decker Mfg. Co., Baltimore.—Stock.— Company has recently increased its capitalization to 000,000 of which is 8% Pref. cum. stock. The first lot $2,000,000, $1,of $250,000 was the benefit of employees and was oversubscribed. For this second block for $250,000 was opened up, both of which lots have been fully subscribed, $368,500 of the new Pref. stock being taken by issued for reason a employees, and the balance of the $500,000 being taken by outsiders. It is understood that in the near future an adidtional block of $150,000 will be put out in order to take care of a number of friends of the Company located throughout Baltimore County who were unable to secure stock of price of coated paper ha 1914 to approximately fifteen cents in 1920. annual cost of $1,200,000 for 1,200 tons of super. typical of all other paper costs; even the Manila wrappers of the Butterick Company the case from five cents a pound in and super from three to nine cehts—involving an for 4,000 tons of coated paper and $2,160,000 These increases are up 200%. As for the second are fundamental, labor, the Butterick Company's printing payroll alone in 1916 was $1,200 a week—today it is $3,600 a week. The union system of shop practice, established during the war, necessitates i n the case of the two-color presses a man to each press in place of one man to two presses; which under the new wage scale results in an increase of 233%. in the case of the men who handle the to $32 a week; and the men who bale $26.50. As to the third fundamental, transportation, the postal rates have gone up 280%, freight rates 100%, and express rates 60%. As a concrete example the increased postage for roll paper on the sidewalk, from $14 the printing house waste, from $10 to $78,000 a year. advertiser some idea of where his advertising the "Delineator" alone amounts to These figures give the ncreased about 200%, while foes. And when we considerthe increase in that the cost dollar of making the agate line has price to the advertiser is only publisher is up against a situation 50%, it becomes evident that every which he cannot long afford to maintain. [From report by "Business Digest Service" 241 W. 37th St., N. Y.; based on an article of 2,600 words in "Printers Ink" V. 113, No. 4, p. 3.]— V. Ill, p. 1281. Calumet & Arizona Mining Co.—Copper Output Decrease.) 1920—11 Mos.—1919. 3,236,000 4,466,000 1,230,000 37,566,000 41,948,000 1920—Nov.—1919. —V. (in Lbs.) Decrease. 4,392,000 Ill, p. 1952, 1474. Cambria Fuel Co.—Bonds Called.— ($56,000) Purchase Money Mtge. 6% Fifty-six 15-year gold bonds of and int. at the Bank¬ City.—V. 109, p. 2266. 1910 have been called for payment Jan. 1 1921 at par ers' Trust Co., 16 Wall St.. N. Y. & Car Canadian Foundry Co., Ltd.—To Liquidate Dividend Arrears Amounting to 22%%—An. Report. Pref. The directors on liquidate the 22%% dividend ar¬ of 6% negotiable The distribution will be made Dec. 31 to hold¬ 14 decided to Dec. the Cumulative Preferred stdck through the issue rears on scrip maturing In 7 years. ers of record Dec. 24. Statement by Pres. W. W. Butler on Dec. 13 to "Montreal Gazette.** company's affairs have gradually adjusted themselves to its regu¬ peace-time production of railway cars and the various specialties in connection therewith, and although the earnings for 1920 have been some¬ what disappointing because of the interruption to continuous work caused by the difficulties in obtaining necessary materials, the full 7% dividend upon the Preference stock has been earned and paid. "The improved position of the material market and better labor condi¬ tions are now exerting a favorable influence on the operations of the com¬ pany; the unfilled orders at this date amount to approximately $20,000,000, and railway requirements are such that a reasonable amount of additional business is anticipated. The directors have, therefore, reached the con¬ clusion that the time is opportune for some action to be taken with regard to the Preference share dividend now in arrears, and they have been advised that if such arrears be distributed before the end of the year shareholders will benefit by this distribution of surplus without liability under the income tax law." See under annual reports above.—V. Ill, Canadian Woollens, p. 2328, 695. Ltd.—Common Dividend No. 2. has been declared on the outstanding $1,$100, payable Jan. 1 1921 to holders of record dividend of 1%% A second par Carib The paid in Oct. last.— Syndicate, Ltd.—New Pass Discovered.— announces that a new pass, through the mountains of company Colombia, has been discovered by explorers for the company, which possible the laying of a pipe line to rich petroleum lands in the See N. Y. "Times" of Dec. 8, p. 25.—V. Ill, p. 1755. makes Andes. Coke Co.—Extra Dividend.— Central Coal & and % of 1 % have been declared on the Common respectively, in addition to the regular quarterly divi¬ dends of 1 % % on the Common and 1 % % on the Preferred, all payable Jan. 15 1921 to holders of record Dec. 31 1920. In July last an extra divi¬ dend of 1 % was paid on the Common stock. Capitalization: Authorized and outstanding, $5,125,000 Common and $1,875,000 Preferred stock, par $100.—V. Ill, p. 192. and Preferred stocks, Central Hudson Gas & Electric Co.—Capital Increase. The company has filed notice at Albany of an increase in its capital from $2,600,000 to $3,500,000. We are officially informed that "this increase in stock is made for the purpose of providing for future conversions of out¬ standing debenture bonds." . $2,600,000 in connection with the sale of $750,000 convertible 7% debentures, due Jan. 1 1929, and the present increase, it is understood, marks the sale of additional convertible The stock was increased in March 1919 to debentures.—V. 108, p. 2125. Cerro de Pasco Copper Corp.—Bonds Offered.—Esti¬ for 1920.—The bankers named below are of¬ fering at 100 and int., to yield 8%, $8,000,000 10-Year Gonv. Sinking Fund 8% gold bonds. (See adv. pages.) Bankers Making Offering.—J. P. Morgan & Co., First National Bank. National City Co., Bankers Trust Co., Chas. D. Barney & Co., Wm. Amated Results (B. F.) Avery & Sons, Inc.—New President, &c.— The directors have authorized the payment Increase in Costs That All Publishers.— Extra dividends of 1 % Payment was to be made either in full or 50% on or balance Dec. 20. Up to Oct. 31 1920 $639,600 of this as capital $7,000,000.—V. Ill, p. 1854. 750,000 Common stock, Chemical Co. have been merged under the above name with a capital of $2,000,000. The plants of both companies furnish artificial gas to the Overland plants.—V. 105, p. 292. Autocar Increase.— filed notice Dec. 6 at Columbus, Ohio, increasing its Dec. 20 1920. An initial dividend of like amount was V. Ill, p. 1186. The Atlas Chemical Co. and the Empire The reports it is likely that the whole merger Buckeye Steel Castings Co.—Capital The company from $4,500,000 to Canadian Atlantic Sugar Steel Corp.—Outlook for Merger Uncertain. British Empire According to the Canadian press plan will be recast and that there will be considerable alteration in the finan¬ cial arrangements, and also of the figures at which certain of the companies shall be included in the merger. It is also stated that the Canada Steamship Lines and a few of the other smaller concerns will be withdrawn from the merger and that itfwill be com¬ posed finally of Dominion Steel, Nova Scotia Steel and Halifax shipyards. —V. Ill, p. 2231. lar holding company will vote Dec. 28 on dissolu¬ incorporated in 1910 in Delaware to take over the and other properties, but none others were ever added. The company has $5,000,000 Common stock authorized and out¬ standing and $1,000,000 Pref. auth., of which $900,000 outstanding. No dlvs. have been paid since 1914. It intends to distribute the stock of Atlantic City Gas Co. (99% owned) among its stockholders.—V. 99, p. 896 * Boston Rubber Shoe Co.—Obituary.— President, died Dec. 9.—V. 88, p. 161. Col. Harry E. Converse, "The Company.—To Be Dissolved.— The stockholders of this tion. Atlantic $900,000 Equally startling are the increases An » issued. [Stock outstanding: Common $25.]—V. Ill, p. 2045,1281, 1086. the first and second lots Pref. $600,000, par for tne same work. Chicago.—Fall in Wholesale Prices.— Armour & Co., [Vol. 111. CHRONICLE THE 2426 Read & Co. and Spencer Trask & Co. Dated Jan. 1 1921, due Jan. 1 1931. Int. payable J. & J. in New York* $1,000 (c*&r*). Red. by operation of sinking fund on any int* date after 60 days' notice at 105% and int. Convertible until and inch Jan. 1 1931, or, if called for red. after 60 days' notice, then until and incl. the redemption date, into stock at rate of 30 shares of stock for each $1,000 of bonds, equivalent to a price of $33 1-3 per share of stock. Columbia Trust Co., New York, trustee. , „ > A semi-annual sinking fund is provided of 20% of net earnings before int. charges and depletion, but not less than $840,000 p. a., to purchase bonds in market at not exceeding 105% and int., or to their redemption Denom. If subsequent mortgage be placed on the real property now if any pledge be made of any of the stocks or securities of the at that price. owned, or Cerro de Pasco Ry. or of the Sociedad Minera Backus this issue Is to be secured by a prior lien thereto. Data from Letter of Pres. L. T. Company.—Incorp. in New York Oct. 26 1915 and other properties in y Johnson del Peru, Haggin, New York, Dec. 14 1920. and owns copper mines Peru. Authorized capital 1,000.000 shares (no shares outstanding. These bonds constitute the entire capital stock of Cerro de Pasco Ry. par value), of which 898,230 he only funded debt. Owns Dec. 181920.] Purpose.—Proceeds THE CHRONICLE will be used to reimburse corporation for expenditures on the construction of the new smelter at Oroya (estimated cost $10,000,000) and to provide funds for its completion, part of the cost of the smelter being met from current earnings. It is expected that this smelter will be in oper¬ ation early in 1922. x Production of Smelter Prior mno^ni'r Organization •—r-- Coast Valleys Gas & Electric Co.—Bonds Approved.— The California RR. Commission has authorized the company to issue $375,000 1st mtge. bonds at not less than 80 and $220,000 10-year 8% notes at not less than 94. The moneys obtained through the sale of the notes are to be used to pay the cost of plant extensions.—V. Ill, p. 1854. to in 1915. —- Since Organization in 1915— and Since Organization in 1915. Copper, Lbs. Silver, Ozs. Gold, Ozs. 340,000,000 19,802,000.00 154,200.000 Coca-Cola Co.—New Director—Dividend.— 69,657,067 71,243,548 70,516,400 57,028,288 4,209,659.62 29,891.677 5,556,735.33 30,068.924 5,051,900.04 28,210.902 ioon7— 5,325,320.93 28,361.217 1920 (partly estimated) 52,334,308 5.959,084.70 22.092.722 x Excluding production of Sociedad MineraBackus y Johnson del Peru, y Net Income Available for Int., Federal Taxes, Deprec. & Depletion, Cat. Yrs. •o V8PM 1917. 1918. 1919. $3,614,217 $12,726,311 $8,866,428 $5,777,417 Earnings for 1920, partly estimated, should be not less than $4,000,000, as compared with $1,440,000 interest and minimum sinking fund require¬ ments on - ----- Ill, p. 2142, 1755. Commonwealth these bonds, Does not include undistributed profits of subordinate companies, which annually for years 1916-1919, inmdends.—Since its organization has maintained regular dividends of $4 annual report for 1919 in V. divs. of $1 75 in 1917 and $1 in 1918. and int.; thereafter at par and int. York' trustoo' i*-.v v. v..' ■ lnn1^ See 110, p. 1847.—V. Ill, p. 2046. was Passaic and Warren in public and private use, own modern Union, Morris and Somerset Counties. « Earnings.—Net earnings for the past 5 years have averaged well sinking fund gold bonds deposited with the trustee.—V. 94, p. over 5% 1510. Computing-Tabulating Recording Co.—Tenders.— The Guaranty Trust Co. of N. Y., trustee, will, until 10 a. m., Dec. 29, 6% 30-year sinking fund gold bonds of 1911, int., to an amount sufficient to exhaust $100,000.— receive bids for the sale to it of atnot exceeding 105 and V. 110, p.2294. Conley Tin Foil Corp.—Dividend Omitted.— Co., The directors have omitted the declaration of the dividend due Jan. An initial dividend of 50 cents per share was paid in July next. last; amount was also paid Oct. 1 last.—V. 110, Consolidated Textile p. a 1 like 2490. Corp.—Listing.— The New York Stock Exchange has authorized the listing of 70,620 additional shares of Capital stock (no par value) on official notice of is¬ suance upon con version of its 3-year 7% sinking fund convertible debenture due April 1 1923 (V. 110, p. 1529) and 535,274 shares on official notice of issuance making the total applied for946,894 (auth. 1,000,000). The purpose of the additional issue of 535,244 shares is to provide funds to acquire (through an existing holding company, B. B, & R. Knight Corp. of notes Chicago Pneumatic Tool Co.—Earnings.— r Sept. 30 '20. $392,515 June30'20. $379,994 Mar. 31'20. 9 Months. $253,304 $1,025,813 Net earnings, after taxes and charges, but before dividends. V. Ill, p. 1952. a Del.) all the outstanding common stock (100,000 shares) no par value of 1375) and for other purposes matter.—Compare V. Ill, p. 2046, 2232. B. B. & R. Knight, Inc., of Mass. (V. Ill, p. in connection with the Compare Consolidated man President B. E. Sunny writing to the "Chronicle" Dec. 9 1920, says: "There will be no new financing in connection with the purchase of the Central Union properties in Illinois by the Chicago Telephone Co. The [$15,500,000] 5% notes delivered to the Central Union will probably be turned over to the American Telephone & Telegraph Co. to satisfy its debt or a portion thereof. "The Chicago Telephone Co. has upwards to $20,000,000 First Mortgage Bonds outstanding which mature Dec. 1 1923, at the same time these 5% and Wm. —The committee named below in circular of Dec. 1 says: The company was organized in 1904 with $4,000,000 (Common) stock, mainly to speculate in real estate. Messrs. Flake & Dowllng became the chief executives, but Mr. Flake died in 1905. Dividends were paid on the Common stock until May 15 1907, but since then only 2% in 1918 with a further 5% recently declared (payable Dec. 20 1920), while this committee was being formed. Operations to date have netted heavy losses notwithstanding two periods of great prosperity. The City Investing Building, 165 Broadway, was opened May 1 1907. The land, building and contiguous property cost over $11,000,000; $5,000,GOO of this was borrowed on first mortgage on 165 Broadway, $1,250,000 Broadway and contiguous property were sold for $10,000,000, netting a loss of nearly $800,000. The annual report of April 30 1920 shows an operating profit of over $686,000. But against this was charged about $796,000 losses accruing on the books during that year, leaving a net loss of $109,000. According to our best Information the aggregate losses in various operations have been over $2,000,000, recouped in part by some fortunate speculations, but largely from the surplus income of 165 Broadway. In our opinion the time has now arrived for liquidation. The book value of the assets is substantially as follows: j Cash & marketable 3,460,000!Total...... $600,000 --$5,850,000 securs_ The above mortgages provide for liberal amortization payments. Prac¬ tically all of the real estate is subject to mortgages, and all but $55,000 of the mortgages owned are subject to prior mortgages. With care we think the Pref. stock can speedily be paid in full (unless the quick assets are previously tied up), and the Common stock paid off, we hope, at over $100 per share. The present nominal market prices of thestock on small sales are about 75 for the Preferred and 60 for the Common. The undersigned already represent a large proportion of both classes of stock. If we secure the support of a majority of the stock, directors will be elected to carry out an economical liquidation, payments on account to be made from time to time. [Signed by committee, Francis K. Pendleton, Chairman, ex-Justice Su¬ Court; Henry S. Thompson, Vice-Pres. Globe & Rutgers Fire Insur¬ Co.; William C. Cox, Vice-Pres. Guaranty Trust Co.; Lorenzo M. Picabia, William R. Stewart, Pres. Rhinelander Real Estate Co., and Frederick J. Middlebrook, with Louis M. Ogden, Secretary, 25 Broad St., New York City.] [President Robert E. Dowling, the largest stockholder, opposes liquida¬ tion, claiming that "the assets are worth $1,000,000 more than the amount of indebtedness"; that no properties have been bought since last winter; that in the last seven years no money has been lost by speculation in prop¬ erty; that next year $500,000 wi'l be coming in from mortgages by reduction and that he expects considerably more than par for his Common stock. ("Wall Street Journal" Dec. 15.) The Pref. divs. have been regularly paid, the usual 1 % % being advertised for Jan. 3.j—Y. 109, p. 2359. *• "* "*r-* I < • a i • V-:-' ■. , j Earnings.—Earnings of the subsidiaries, year ending June 30 1920: Gross, $690,878; net, after taxes, $220,207; total interest charges, $81,341; annual interest on $250,000 8% notes, $20,000; balance, surplus, $118,866. Security.—Secured by deposit of $370,000 underlying mortgage bonds as follows: $220,000 Kansas Electric Utilities Co. 1st 5s, 1925, and $150,000 Miami Valley Electric Co. 1st & Ref. 6s, 1945. Consolidation' Coal Co.—New Offices.— The company, it is reported, leased the 18th floor of the 25-story office now being constructed by the Munson Steamship Line at Wall and Pearl Sts.. N. Y. City.—V. Ill, p. 2046; V. 110 p. 1293, building 1191, 1180. Cosden & on second mortgage, and to clean up construction bills, the company in 19081909 issued for cash at par $1,000,000 of Pref. stock. This last was taken by the stockholders. In February 1920 165 Co .—Notes Ross & Callable at 105 and int. on 30 days' notice. Commercial Trust & Savings Bank, Chicago, trustee. Organization.—Incorp. Nov. 26 1915 in Delaware. Owns and controls, through stock ownership, Kansas Electric Utilities Co., Union City Electric Co., Miami Valley Electric Co. and United Lighting Co., serving exclusively electric light and power to 20 cities and adjacent territory in Kansas, Indiana Ohio and Pennsylvania. Purpose.—Proceeds are to be used to pay the cost of extensions and bett/CnriOTi t'8 *:'•' City Investing Co., N. Y.—-Committee Seeks Liquidation. L. Continental & "If the market is favorable in 1921, the Chicago Co. may do some fi¬ not been very seriously discussed thus far." Co. Current Assets— Cash (of Del.).- Current Assets, &c.— Oct.21'20. Current. Liabil.— Oct.31'20. June 30'20. Jwnt.30'20. payable, $1,678,139 4,513,355 Material & supp-. 2,855,365 2,887,090 Notes & acc'te ree. 3,870,318 4,017,281 Notes U.S. Lib. bonds-- Int., accr. taxes & $2,531,051 Inventory , - 4,474,197 24,156 22,950 Total Results for $599,620 $2,022,852 2,505,747 2,748,349 Acceptances dlse'd Total 41,974 Fed.taxes - Ten Months ending Oct. 705,000 ----- Dividends $13,755,087113.118.815 — — Accounts payable res. for 21,735 940,619 800.360 -.$4,330,562 $6,055,694 31 1920: Net Income, after deducting operating expenses, interest, &c_.$12,627,587 Reserve for Federal taxes 602,880 Balance, surplus, applicable to dividends $12,024,707 See earnings by months in V. Ill, p. 2233, and compare V. Ill, p. 1288. reported as saying that "the company's entire gasolene out¬ put has been sold to the Standard Oil Co. of Indiana up to March 1921, and that the refinery is running at capacity and is experiencing no difficulty in obtaining crude."—V. Ill, p. 2233. An official is Crane Company, Chicago.—200% Stock Dividend.— A 200% stock dividend has been declared on the $13,530,500 Common stock, par $25. This distribution will increase the outstanding Common stock to $27,061,000. The company, it is reported, will also distribute $2,200,000 cash among its employees.—V. 110, p. 2196. preme Creamery Package Mfg. Co.—Dividend Increased.— ance Co. Dated Oct. 1 1920. due Oct. 1 1925. Int. A. & O. in Chicago and New York without deduction of normal Federal income tax up to 2%. Denom. nancing, but the matter has —Compare V. Ill, p. 2232. (cost) _$1,790,000 & $1,000, $500 and $100 (c*). notes mature. ..... Utilities Offered.—CounselCo., Inc., Chicago, are offering at 98 and int., to yield about 8%%, $250,000 5-Year 8% Coll. Trust Gold Notes. A circular shows: Chicago Telephone Co.—Issues $15,500,000 5% Notes for Central Union Properties—Possible Financing in 1921.— real est. " twice the entire interest charges., ; k .1 Security.—Each $1,000 note is secured by $1,300 1st & Ref. Mtge. V. 110, p. 2079. Equities In Mortgages $2,395,000. ships of Chatham, Chicago, are offering at 100, to net 6%, $320,000 6% 1st Mtge. Chicago Real Estate Gold bonds, secured by land and building occupied by The Channell Chemical Co. The bonds are a direct personal obligation of the owner of the property, Chas. A. Channell, President of the company.— Quarters ending Net earnings. over The Commonwealth Electric Co. furnishes current from its The a New *« Sower plant, for domestic, commercial and New Providence and the Town¬ ghting in the City of Summit, Borough of public uses, including all street company has severed all connection with the O-Cedar Mills Co., and on the bonds of this comoany has been amply protected. Purpose.—To provide funds to enable company to take care of its rapidly expanding business, both at home and abroad. Trust .y...■ come. Its guaranty & Co., • notes supply enable it to cater to the English demand and, in fact, supply from this point all British possessions. The company has acquired the Aladdin dye soap. Bank ■.v trust is drawn from wells in the Canoe Brook and Baltusrol Valleys, where the company owns reservations aggregating 1,145 acres, enbracing undeveloped sources of supply to take care of the increasing demand for many years to months ending July 31 1920 were $269,875, dividend requirement of $6 per share on the Class giving effect to present financing. Estimated earn¬ ings, before taxes, during fiscal year about $600,000. Sales to Sept. 1 have been $2,375,000; estimated sales for full year, $5,000,000. Company.—Manufactures the "O-Cedar" polish, used in decorative cleansing polish for furniture, floors, woodwork, &c. This polish is sold over. The company is now doing in England a business of $1,000,000 per annum, and plans to establish a factory in London which will Sons Trust t■ miles of water mains, 11,000 water meters, 1,100 hydrants, 1,200 acres of land, office buildings in Summit and West Orange, power houses, pumping machinery, and 40 or more driven and artesian wells. The water Earnings for the 7 Offered.—Greenbaum & .* The Commonwealth Water Co. furnishes water for orover the entire annual A shares, without Bonds ,i.. including fire service in the City of Summit, the Towns of Irvington and West Orange, the Borough of New Providence, and Townships of South Orange, Millburn and part of Springfield. It owns approximately 175 (40,000 shares) and Class B" shares)—both having voting powers—with no bonds, mortgages or preferred stock outstanding (it being the intention to retire the present Preferred stock). The Class "A" Common stock shall have preference oyer the B shares, both as to assets and dividends, and shall participate equally with the "B" stock in the further profits of the company after $6 per share has been paid on both classes. ; Earnings.—Total net earnings for the 9 years 1911-1919, incl., were 260% or the outstanding capital stock, or average net earnings of more than 40% per annum. •• y-. (incl. (6%) stock $190,000; 2nd Pref. (7%) stock, $300,000; Common stock, $500,000. Properties.—The company owns all outstanding bonds and stock (except directors' shares) of Commonwealth Water Co. and Commonwealth Electric Co. which companies serve without competition a population of about 60,000 and 25,000 respectively. The value of the properties in 1920, as approved b> the New Jersey P. U. Commissioners for rate making purposes, of Common stock Class 'A" (ou.UUu Farmers' Loan Capitalization.—Mortgage bonds, $969,000; collateral this issue), $400,000; 1st Pref. Channell Chemical Co. of Illinois, Chicago.—Stock Of¬ fered,—P. A. Brewer & Co., Chicago, are offering at $62 50 per share, to yield on regular divs. over 9^%, 40,000 shares of Class A Common stock of no par value. A circular shows: Capitalization.—Upon the completion of the present financing capital /on & Notes— Dated Dec. 1 1920. Due Dec. 1 1935. Denom. $1,000 (c). Int. payable J. & D. in New York. Company agrees to pay the U. S. normal income tax up to 2%. Red. on any int. date on or before Dec. 1 1926, at 110 and int., and between Dec. 1 1926, and Dec. 1 1932, at 105 r2 ^Jen*ged approximately $1,000,000 extra Water Light Co. of N. J.—Note Offering.—F. M. Ckadbourne & Co. of Newark, N. J., are offering at 953^ and int. netting about 7lA% $200,000 15-year Collateral Trust 7% Gold Notes of 1920. y and paid V. Charles Hayden of Hayden, Stone & Co. has been elected a director. regular semi-annual dividend of 3K% has been declared on the $10,000,000 Preferred stock, payable Jan. 1.—V. The _____ per share 2427 A quarterly dividend of 2% has been declared on the outstanding $3,000,000 Common stock, par $100, payable Jan. 10 1921 to holders of record Jan. 1 1920. Quarterly dividends of 1 % % were paid during 1920, Including an extra dividend of 5% paid in January.—V. 110, p. 363. Crompton & Knowles Loom Works.—Obituary.— President Lucius J. V. 110, p. * Knowles died In 2079. London, England, on Nov. 26.— . < : Crucible Steel Co. of America.—New Director.— John H. Fulton of the National City Bank of N. Y.. has been elected a j director.—V. Ill, p. 2329, 2233. Dec. 31 Dodge Bros., President Horace Detroit.—Obituary.— value) of The . Compare The East Bay Water Co.—Voting Trust Ends. Branch, Mining Eagle & Blue Bell Set receipt, upon payment and in lieu thereof will be issued a non-negotiale the aforesaid which this dividend and such further dividends, ir any, out of the small sum reserved for unadjusted claims, &c., will be paid promptly by check. Digest of Circular from Co.—Dividends.— has been declared out of earnings, to¬ gether with a dividend of 15 cents per share out of reserve for depletion, as a "return of capital" payable Dec. 23 to holders of record Dec. 17. In April last, a dividend of 10 cents per share was paid; compared with dividends of 5 cents each paid in March and Sept. 1919. This makes a total of $1.75 per share paid in dividends since Feb. 11913.—V. 110, p. 1645. A dividend of 10 cents per share Edison Elec. Ilium. Co., Brooklyn.—Final See Brooklyn Edison Co. in last week's "Chronicle."—V. Distribution. 83, p. 215. Electrical Development Co. of Ontario, Ltd.— See Toronto Ry. under "Railroads" above.—V. 104, p. 955. Elizabethtown (N. J.) Gas Light Co.—Rate Increase.— P. U. Commission has revised its order of May 12 1920, of the company from 90c. to $1 15, and issued an order permitting the company to charge $1 40 per 1,000 cu. ft. for gas. When the company was granted the $1 15 rate, after applying for a charge of $1 50, it appealed to the Supreme Court. Justice 8wayze held that the rate was Insufficient, which led to a reconsideration of the case, with the The New Jersey Empire District to of the first Approved.— Preferred Pound.— on Dec. 15.— Rubber Co.—Earnings.— showing: Sales, of $9,396,912, current liabilities, losses, $8,- Body Corp.—Take Over Ohio Corporation.— exchange one share Ohio Co. Common share of the latter Common. The former also agrees in connection with the purchase of the latter through this exchange, which directors of both companies have approved to issue dividend charges of Fisher Body Ohio Co. Preferred and to pay off the accumulation of back dividends on that issue [amounting to $8 a share for 1920] within 18 months. 1 ("Boston News Bureau."). The Fisher Body Corp. (controlled by the General Motors Corp.) has a controlling interest in the Fisher Body Ohio Co.'s 100,000 authorized and issued shares of Common stock of Jdo par value (Compare V. 109, p. 1612.)— Body Corp. of New York has offered to of its Common stock for every 5 shares of Fisher Body stock and to pay in addition $2.50 per share upon every V. Ill, p. 2143. Ohio Co.—Probable Fisher Body See Fisher Body Corp. Acquisition.— above.—V. Ill, p. 1756. Chicopee Falls, Mass.—Omission of of Both Pref. Dividends—Status— Outlook.—President H. T. Dunn in circular of Dec. 13 says: Dividends.—The general situation due to trade and credit conditions throughout the entire country is such that the directors feel it advisable to conserve the cash resources and in consequence voted to omit the quar¬ terly dividend of 76 cents a share on the Common stock which would have Fisk Rubber Co., Common Dividend—Payment during payable Jan. 1, notwithstanding it had been more than earned the year. The regular dividend of \%% on the 2d Pref. stock payable Dec. 15 to stockholders of record Dec. 1, and the dividend of 1 % % on the First Pref. stock payable Feb. 1 to stockholders of record Jan. 21 will be paid. No comment is necessary as to the trying situation all industry has found Itself in during the last few months, for it is apparent to all, but our faith been in the future of our country, our company and the direct industry continues * to be unbounded. Sales—Status.—Our sales for 1920 as compared with $43,600,000 for jPflities8 thoroughly will run approximately 1919. stock now held. letter to the stockholders states that when selling of motor cars stopped as though over night the company took im¬ mediate steps to stop incoming materials but before this could be accom¬ plished, inventory increased in excess of $500,000. Based upon spring and early summer demand the inventory could have been quickly liquidated, but with the almost complete stoppage of sales, no such liquidation is possible. As a result the company now faces the neces¬ sity of financing a big and valuable inventory, until the resumption of buy¬ ing which will rapidly provide funds for all requirements. Interests identified with company early in 1920 acquired control of H. J. D. A. Shaw in a President Cleveland, manufacturer of automobile engines. The 60,000 of the 100,000 shares outstanding, according Walker Co., chase covered pur¬ to a Hopkins, V.-Pres. of the Grant Co. H. J. Walker, Norman Walker and W. C. Dunn, officers and directors of the H. J. Walker Co., are succeeded by D. A. Shaw, Ben. S. Hopkins and George Salzman, as Pres., V.-Pres. and Treas., respectively. Mr. Salzman also will serve as Gen. Mgr. of the H. J. Walker Co., of which F. W. Treadway is Sec. These officials with A. R. Fraser of the Guardian Savings & Trust Co., Cleveland, compose the board of directors.—V. 109, p. 1613. statement by Ben. F. The annual report for year ended Oct. 31 is quoted as $114,980,969, against $91,078,514 in year 1918-19; profits against $9,306,978. Current assets Oct. 31, $73,732,503; $32,684,568. Provision out of year's earnings for inventory 151,749.—Y. Ill, p. 2233. Fisher of stock and $2 of Common 392. The Fisher liens for the expenses Grant Motor Car Corp.—New Note Issue.— The company is offering to stockholders an issue of short-term notes bearing 8% int. and maturing on or before Nov. 1 1921. The notes are being offered at 95, on a basis of $20 a share for each share of 106, p. 1342. Firestone Tire & the small profit order, there resulted reserved $37,443 against thereof to be distrib¬ Court costs, &c., balance of $1,234,035, less H of 1% the committee.—V. 111. p. 497. plant and securities and realized from operating the property under court total of $1,304,382, from which the Court has claims filed but not finally adjudicated, any balance uted to the bondholders. There was also allowed for the sum of $32,904. After these deductions there is a which is now to be distributed as a dividend in liquidation, Relations has granted the company Federal Sugar Refining Co.—Sugar at 8c. a The company quoted refined sugar at 8 cents a pound V. Ill, p. liens. sale of the property, From the and our failure to purchase of reorganization dated July 26 competitive bidding, the liquidating 35% to 41%, or $410 per $1,000 of rendered inoperative the plan As a result, however, of our value was raised from an estimated 1920. right to issue at 88 $1,725,000 1st Lien & Gen. Nov. 1 1939. The bonds will be issued to redeem obligations now ing and unpaid, of which a large part have been due On July 26 1917 the Court granted the company permission to bentures amounting to $491,000, and on Oct. 27 1917 approved additional debentures, and another issue of $842,000 on May These represented short-time borrowings at ordinary rates ("Topeka Capital.")—V. free for deposit. chiefly by the cash made approximately 70% of the bonds the property the Mtge. 8% gold bonds, due outstand¬ since 1917. issue De¬ $368,000 11 1920. of interest. The company showed the Court that it had been able to find a market for only $106,000 of these obligations. About the time of the last bond issue, permission was also granted to Issue $2,000,000 of short-time notes. The Court's order provides that this issue shall be withdrawn. Company is controlled by Cities Service Co. of Industrial The Kansas Court Nov. 30. At the foreclosure sale our bid was limited available by the bondholders and stockholders, See V. Ill, p. 993. allowed. Electric Co.—Bonds Bondholders' Committee, William J. Casey, Chairman, bondholders deposited their bonds, aggregating $1,574,830 of first liens, out of a total of $3,070,038. As there were many bonds held In Germany and by trustees, the bonds actually deposited with us amounted About 500 First Mortgage Sale.— in increasing the rate result that the $1 40 rate was Calvert and Redwood streets, to pay to the holders of the fol¬ allowed thereon in the fore¬ closure proceedings in the U. S. District Court for the Dist. of Md., viz.: (a) $410 for each $1,000 1st Mtge. 4% bond of 1901, with coupon due March 1 1920 and all subsequent coupons attached; (6) $414 02 for each $1,000 6% Coupon Funding bond of 1914, with coupons due March 1 1920 and all subsequent coupons attached; (c) for unfunded coupons of earlier matur¬ ity than March 1 1920 upon said 1st Mtge. bonds, at the same rate as upon the 1st Mtge. bonds, with allowance of interest to March 1 1920. The securities named must be surrendered for cancellation in order to certificates may on Jan. 1 1921 exchange same for shares stock at the Mercantile Trust Co.'s Savings Union cor¬ ner Grant Ave. and O'Farrell St., San Francisco. The new certificates will be ready for delivery on Jan. 25 1920.—V. Ill, p. 1953. Holders of trust Mercantile Trust & Deposit Co., gives notice that it is prepared named securities the dividend Baltimore, lowing In 1919.—V. Ill, p. of capital circular, &c., V. Ill, p. 2329. Gottlieb-Bauernschmidt-Straus BreWing Co., Balti¬ more.—Payment of Dividend Allowed in Foreclosure.— with $489,555 $725,544 in 1920, compared Rubber Co—Monthly Sales.— against expected sales of $250,000,- circular cited last week shows, as following: , _ Sales Aggregating $204,856,159 for 12 donths Ended Oct. 31 1920. Mar. 1920—$21,589,341 July 1920._$17,000,138 Nov. 1919—$11,921,330 April 1920— 17,690,389 Aug. 1920— 18.872,791 Dec. 1919— 16,318,189 Jan. 1920— 19,208,951 May 1920._ 20,468,593 Sept. 1920— 13,659,718 June 1920— 19,470,597 Oct. 1920— 11,132,878 Feb. 1920— 17.523.244 • and loss surplus, 2142. 17. j 000, the —Earnings.— Dominion Glass Co., Ltd.1920. 1919. Sep*. 30 Yrs.— 1920. 1919. Pref. div. (7%)..$182,000 $182,000 Profits $757,988 $631,724 Com. div. (4%).. 170,000 170,000 Bond Interest. i20,000 120,000 Balance, surplus.$235,989 $109,724 Sinking fund •_ 50.000 50,000 Total profit 1665. Goodyear Tire & Sub. Co. Stk Dominion Foundries & Steel, Ltd.—Offers The stockholders were recently offered the right to subscribe to $800,000 7% Cumulative Pref. stock of the Adirondack Steel Foundries Corp. at par ($100), with a bonus of 3 shares of Common stock (no par the subsidiary company for each share of Pref. The terms are 10% with subscriptions and the balance within 30 days. The time within which subscriptions were to be received was originally fixed for Dec. 10 but has been extended to Jan. 5 1921 . The Dominion Foundries built the Adirondack Steel plant and owns all its issued stock less a small amount sold. Production was started in August. The Adirondack corporation owns 29 acres of land and a large modern steel casting plant under construction and in partial operation, located at Watervliet, N. Y.—V. 108, p. 2244. will be made to holders of record Dec. This distribution 1920. Ill, p. —V. / 10,—V. Ill, p. 77. E. Dodge, died Dec. [Vol. 111. CHRONICLE THE 2428 $42,000,000 net The financial position of the com- sound, with quick assets in the ratio of 2 to 1 to its liar while larger than during normal times are composed in standard salable sizes; 87 % of all tires consumed are 4 in. and under, and this percentage prevails in our stock. The company intends to mark down its stock of cotton fabrics, rubber and other materials at the end of the year to sound values and will be able to effect such readjustment out of 1920 earnings and without drawing on the Our inventories the finished stock of Western Power Co. Great of Calif.—Bonds Offered.— Cyrus Peirce & Co. and Bonbright & Co. are offering at 100 and int. yielding from 10.75% to 8.35% according to date called by lot, $1,500,000 (Second Series) Gen. Mtge. Conv. 8% Gold Bonds. Auth. and issued, $5,000,000. Dated Aug. 1 1920. Due Aug. 1 1930. E. H. Rollins & Sons, A circular shows: | Sinking Fund.—Beginning Aug. 1 1922, company will pay an annual sum to retire bonds by lot at 105 and Int., sufficient, when paid annually to and including 1930, to retire the entire issue. This sum will amount to $583,333 and int. on Aug. 1 1922, if $5,000,000 bonds are outstanding. Collateral Security.—To be later secured by the pledge of an equal par value of new Series "B" 7% bonds when issued under company's 1st & Ref. shall have been of Gen. M. Conv. 8% equally with the $6.000,000 Series "A" 6% 1st & Ref. M. bonds now outstanding. No addi¬ tional bonds may be issued under the 1st & Ref. M. until there shall have been pledged Series "B" 7% bonds to the full par value of the Gen. M. M. dated March 1 1919, and after $3,500,000 of said bonds pledged as security for the first series of $3,500,000 bonds. (V. Ill, p. 899). The Series "B" 7s will rank Conv. 8% bonds outstanding. price of par and interest Fund at 105 and interest. 1926 1927 1928 1929 1930 8.89% 8.71% 8.58% 8.48% 8.41% 8.35% Capitalization as of Nov. X 1920. Yield which these Bonds will Return at the purchase if Drawn for the Sinking 1925 1923 1924 10.75% 9.67% 9.18% 1922 Called Yield Common $27,500,000 3,865,684 stock Cum. (incl. $1,992,700recently underwritten)__ Debentures, 1925 General Mortgage Conv. 8% Gold bonds [in two series of $3,500,000 and $1,500,000. Both series will ultimately have same security, but the Second Series will not be additionally secured by the pledge of Series "B" 7% bonds, or be convertible into them, until after Series "B" bonds shall have been pledged for Pref. stock, 7% 6% the security and conversion of the First 8% bonds] Series of $3,500,000 —_ 4,177,600 $5,000,000 6% bonds, Series "A," due Mar. 1 1949 [$5,000,000 new Series "B" 7% bonds ranking equally with these will when issued be pledged as security for and into which the Gen. M. Conv. 8% bonds are to be convertible] 6,000,000 Underlying Divisional Mortgage 5% bonds -—— First Mortgage 5% bonds, 1946 (closed mortgage) Purpose.—To reimburse the treasury for expenditures already made on the company's distributing system, and to provide funds for betterments to the company's system during the next 12 months. First & Refunding Mortgage 3,287,200 20,519,000 additions and based 1921.(est.) Gross excl. of int. during constr. $5,154,258 $5,745,888 $6,750,000 Operating exp., taxes, rentals, &c 2,268,148 2,886,691 3,000,000 Net earnings $2,886,110 $2,859,197 $3,750,000 Annual int. requirement on all outstanding mtge. bonds of the Co., including this issue. — 1-951,080 1,951,080 Annual int. requirement on all outst. debentures— 250,656 250,656 Surplus over Interest charges $657,461 $1,548,264 This surplus is shown without benefit from proceeds of recent financing General American Tank Car Corp.—Dividends.— and exclusive of $464,230 interest during construction ordinarily included A semi-annual dividend of $1 50 has been declared on the outstanding in earnings. Compare full description of bonds of first series with com¬ Common stock, no par value, payable Jan. 1 to holders of record Dec. 15. previously accumulated surplus. Outlook—The prospects for spring business are very encouraging, our orders to date comparing most favorably with the same period a year ago. We believe that the motor industry will have a revival by spring but we are not dependent on that source for our principal outlet, as less than 25% of our total sales are sold to manufacturers for original equipment, more than 75% being distributed for resale to the ultimate consumer by over 40,000 dealers supplied from our own wholesale branches. The regular report for year 1920 will be rendered as usual early next year. —V. 110, p. 2074. Common dividend record: $1 50 incl.; May last, 50 cents per quarterly from Apr. 1919 to Apr. 1920 share, and July last 50 Co.—Dividend Date Changed.— the date of payment of the regular 1>£% on the Preferred stock, from Jan. 3 1921 to General Chemical The directors on Dec. 13 changed quarterly dividend of cents.—V. Ill, p. 1954. Earnings (Reclassified) with Estimate for on 12 Months Ended Oct. 31— Year Ending Oct. 31 1921 present rates. 1919. 1920. earn., plete description of property, Guantanamo Sugar James and O. G. George R. Gage, Second Co.—New 899. „ Officers—Annual Report. elected President to succeed the late William Bunker has been elected First Vice-President Vice-President & Gen. Mgr. H. Post has been Moore Carson. &c., in V. Ill, p. Dec. 181920.] THE CHRONICLE munder "Financial Reports" and "Reports and Docu¬ in last week s "Chronicle"—See V. Ill, p. 2322, 2330, 2335. ments Gulf States Steel Co.—Earnings.— earnings for November after . the usual deductions for taxes, deprecia- w?«?^oarwKun^SJL!10 *50,655, and for the eleven months ending Nov. 30 p?2143. compares with $110,603 in Nov. 1919.—V. 111. Hadfield-Penfield Steel Co. (formerly American Clay Machinery Co.).—Bonds Offered.—Central Trust Co. of 5r22~ u.pklcag°> are offering at 100 and int. 51,000,000 8% Coll. Trust Gold Bonds: to yield 8% JSSa1 ^. Maturing $250,000 each Sept. 1 1922 and 1923 and $500,000 Sept. 1 1924. Denom. $100, $500 and $1,000. (c*). Int. payable M. & S. at Central Trust Co. of Illinois, Trustee, without deduc¬ tion for Normal Federal Income tax at 101 and int. Data from Letter of President R. C. Penfield, Nov. 29 1920. Business .—The business record of company, through one of its constitu¬ ent corporations, extends as far back as 1860. The present corporation is a consolidation, in 1906, of two long established companies, pioneers in the manufacture of clay working machinery in the United States. Business has steadily increased since consolidation, until now it is generally regarded as the most prominent manufacturer in its line, producing substantially 50% of the clay working machinery manufactured In this country and dis¬ tributing its product throughout the United States, Canada, West Indies, 8outh America bo and the Orient. In addition the company has gradually that at present its developed a number of other lines We can only repeat our previous denial of collusion with any competitor regarding prices. No one connected with the company having the slightest authority regarding prices has ever had any understanding with any com¬ petitor concerning prices. We contend the Commission has acted without warrant or justification in seeking to revive the Government's suit. That subject was not men¬ tioned In the Senate resolution calling for this report and its discussion and recommendation in the report appear mere volunteer criticism of imp°rtant department of Government by a minor bureau. This report presents no new fact on this subject except its distinct find¬ ing that the company's percentage of trade in lines which the Commission accuses it of dominating continues steadily to decrease. As record shows and as we have previously stated, the Federal Court's definite period in which to make certain changes period has not expired and there is no intimation that faithfully carrying out the terms of the decree. decree gave this company a In its business. That the company is not 2% Stock Dividend—Buys Plant Site at New Orleans.— A 2 % stock dividend has been declared on the Common stock ($90,000,000 outstanding, par $100), payable Jan. 25 1921. The regular quar. div. of 14%, yas also declared on the Common to holders of record Dec. 24 1920. A stock, payable Jan. 15 1921 both 12)4% stock distribution was made September last, increasing the outstanding Common stock from $80,000,- in 000 to $90,000,000. • The company has purchased a site for the erection of a twine factory and export warehouse at New Orleans, La., at a price stated to be about $3,000,000. The site contains 26 acres with 600 ft. river frontage. The com¬ pany has also arranged with the Dock Board for the erection of docks to cost about $250,000. Pres. Harold F. McCormick says: "It is not possible at this time to state exactly when construction will begin or how extensive the first units product comprises: clay working machinery, cement working machinery, Diesel engines, gasoline locomotives, marine equipment, general and special machinery including crane and brick handling apparatus, spare parts and extras for above, gray iron and steel castings, projectiles. English Co. Acquires 40% p. amount of .work for the U.S. Government and in connection with this work into close touch with the management of Hadfields Ltd., of England* The English corporation being desirous of establishing a permanent Ameri¬ can on Interest.—During the war company did a large of the plant will be. However, it is our desire to utilize this very for¬ tunately situated property as soon and as fully as possible."—V. Ill, 1756. International Mercantile Marine Co.—Pref. Dividend. came connection, an agreement was entered into whereby Hadfields Ltd. acquired a 40% int. in the American Clay Machinery Co. (V. 110, p. 2569), giving in return to the American company practically an exclusive license to use its patents and processes in the United States, and arranging for direct co-operation in the installation and working of such processes. Changes Name.—To indicate its control of the Hadfield process in this country and for the further reason that the American Clay Machinery Co. had so broadened its manufacturing lines as to make its name somewhat misleading, It was thought best to change the name to above title. This was effected in April 1920 (V. 110, p. 2571). Purpose.—By reason of the depreciation in sterling exchange at the time Hadfields Ltd. acquired its interest in company, deferred payment was arranged, the English company giving in lieu of cash, its 2H, 3H and 4)4 bearing year interest In view of the notes. > rapid increase in the company's business in all departments and the magnitude of its present contracts,—a single contract with the U.S. Navy Department alone involving over $3,000,000—the management has felt it advisable to increase its working capital immediately through antici¬ pation of the payment of the Hadfields notes. The proceeds of the bond issue are to be used for the following purposes: (1) To retire an underlying bond issue of $300,000. together with two small mortgages upon recently acquired property, (2) To red uce bills and accounts payable. (3) To increase working capital. « Security.—Secured by deposit with trustee, of $1,166,7005% notes issued by Hadfields Ltd., payable in U. S. currency in New York, dated Jan. 2 1920 and maturing $250,000, July 1 1922; $250,000, July 1 1923 and $667,700, July 1 1924. Income Account Year ending Dec. 311919 and 6 months ending June 30 1920. 1919. Net sales $1,290,682 653,799 $376,167 36,071 $401,091 11,875 $412,238 profit $412,965 Net profit from sales........... Other income, lees adjustments Net profit before interest 1920(6 mos) $2,879,706 718,339 ......... Gross factory .... Net earnings before interest are at the rate of over 5 times maximum interest charges for 1919 and for the first 6 months of 1920 were likewise in excess of 5 times total annual interest charges. Capitalization after this Financing— 7% Cumulative preferred stock Authorized. ... Common stock (no par value) 8% Collateral notes (this issue) Issued. $20,000,000 100,000 sh. $793,000 1,000,000 Plants.—Permanent manufacturing plants are located at Bucyrus and Ohio, combined floor space, 275,900 sq. ft. The plants of the company's subsidiary organized In connection with its war work and located at Kensington, 111., and South Plant Bucyrus and Mansfield, a floor area of 335,400 sq. ft. These latter plants, however, will have the to Government upon the liquidation of the company's claim. Officers.—Pres/, R. C. Penfield; V.-Pres. & Treas., L. W. Penfield; Sec. & Res. Mgr., R. O. Perrott; Vice-Pres., J. P. Penfield; Asst. Sec., E. A. Baker; Sales Mgr.. C. B. Sharer.—V. No extra disbursement on declared.—V. Ill, p. 2047. was account of arrears, which amount to 42 %, International Motor Truck Corp.—Sales.— Sales of "Mack" trucks in Nov. showed an increase, it is stated, of 43% Oct. last; for the 3 months period ending Nov. 30, sales showed an increase of 18% over 1919.—V. over Ill, p. 1857. Interstate Window Glass Co.—Merger.— Incorp. in West Virginia (on or about Oct. 23 1920], representing a glass plants in Pa., W. Va., Ohio and Okla. The soon after Jan. 1.' This merger is said to covering the use of patents against several independent concerns won by the American Window Glass Co. American merger of from 12 to 15 merger will become effective be the outcome of litigation Window Glass Co. machines are to be used on a royalty basis by the new company, and production will be largely increased. The companies merged include Pennsylvania Window Glass Co., Kane (Pa.) Glass Co., plants of Consolidated Window Glass Co. at Hazelhurst Jewett, Pa.; Empire Glass Co., Shinglehouse, Pa.; Smethport (Pa.) Glass Co., Gamp Glass Co., Huntington, W. Va.; Crescent Glass Co., Weston, W. Va.; Tuna Glass Co. ana West Fork Glass Co., Clarksburg, W. Va.; Columbus Glass Co., Lancaster, O.; Okmulgee (Okla.) Window and Mt. Glass Co. Officers.—H. J. Walter, Bradford, Pa., Pres.; T. W, Camp, Smethport, V.-Pres.; W. S. Calderwood, Kane, Pa., V.-Pres.; F, D. Gallup, Smethport, Pa., Sec. & Treas. Directors.—H. J. Walter, Bradford, Pa.; T. W. Camp, George W. Mitchell, Smethport, Pa.; T. F. Koblegard, Weston, W. va.; Henry Mo Sweeney, Atlantic City, N. J.; Charles Wandless, Lancaster, O.; Charles L. Surh, Oil City, Pa.; A. H. Gacney, R. A. Hill and W. S. Calderwood. Kane, Pa. ("Manufacturers' Record," Dec. 2.) Compare annual report of American Window Glass Co. in V. Ill, p. 1748. Pa., Island Creek Coal Co.—Dividend Increased.— A quarterly dividend of $1 50 per share has been declared on the out¬ standing Common stock, payable Jan. 1 1921 to holders of record Dec. 24 1920. Dividend record: On Common Stock— *12. '13-'14. '15-'16. '17. '18. '19. '20. Jan. '21. $4 $8 p. a. $8 p. a. $9 $9 $4.50 $4 $1 50 Regular Extras —V. $3 ... Ill, p. $3 p. a. $2 __ — $2 ... 2144, 1284. Jones Bros. Tea Co.—Dividends.— While customarily the directors meet for dividend action on the third Thursday of December, it was learned on the Common stock to-day that the but an adjourned meeting instead will take place on Jan. 10. It was said semi-officially to-day that It was quite likely that no Common stock dividend will be declared in view of the general business situation. The quarterly dividend of 1M % on the Preferred stock will be paid on Dec. 31 to holders of record Dec. 22. i "Financial America" Dec. 17.—V. Ill, p. 2144. meeting 110, p. 2571. was not held this year, Kaministiquia Power Co., Ltd.—13^% Stock Dividend. Hamilton, Harris & Co., Indianapolis.—Merger.— A It is stated that the directors have decided to increase the capital stock from $500,000 to $4,000,000 (to consist of $2,000,000 Pref. and $2,000,000 Common), 16 declared the usual semi-annual dividend of 3% 1921 to holders of record Jan. 14 stock, payable Feb. 1 1921. 100,000 sh. 1,000,000 Willoughby, revert The directors on Dec. the Preferred 1314% stock dividend has been declared on the capital, payable in Dec. 23 to holders of record Dec. 17. This distribution the outstanding capital stock to approximately $2,500,000. Common stock will increase and to merge the following Indiana tobacco concerns: —v. 106, p. 194. Vigo vJ Tobacco Co. of Terre Haute and Vincennes; O. H. Dailey & Co. of Kokomo, * and the Dailey Cigar Co. of South Bend. L. O. Hamilton and E. W. Har¬ & ris of Hamilton, Harris & Co., it is The holders of the $500,000 1st Mtge. 7s dated stated, are large stockholders in all of July 1 1920 will vote the companies involved in merger and are directors of each. Dec. 29 on authorizing the company to issue $1,000,000 additional bonds under a new mortgage and to exchange the present issue of $500,000 bonds Hartford Automotive Parts for a like amount of new bonds bringing the total amount of bonds to be The company has filed a certificate of an increase in issued under the new mortgage up to $1,500,000.—See V. Ill, p. 697. capital stock by Kaministiqua Pulp Paper Co., Ltd.—Bonds.— Co.—Capital Increase.— $500,000 (par $50) making total capital $2,000,000.—V. Ill, p. 593. Hazel-Atlas Glass (George E.) Keith Co., Co., Wheeling, W. Va.—Stock Div.— President George E. Keith died A 20% stock dividend was payable yesterday, Dec. 17, increasing the outstanding capital stock, par $100, from $7,992,300 to $9,590,760. The company also has outstanding $850,000 6% gold bonds, dated June 1913.—V. 110, p. 365. Hillcrest Collieries, Ltd.—Bonus of 1% in Cash.— A bonus of 1 % has been declared on the outstanding $1,000,000 Common stock, par $100, in addition to the regular quarterly dividend of 1)4%, both payable Jan. 15.—V. 107, p. 1290. Holt Manufacturing Co., Stockton, Calif.—Obituary.— President Benjamin Holt died Dec. 6.—V. 110, p. 2492. Houston (Tex.) Lighting & Power Co. 1905.—Bonds Offered.—Halsey,Stuart & Co.,New York are offering at 82 and int. yielding 7^% $500,000 1st Mtge. 5% Sinking Fund Gold Bonds of 1911. Due April 1 1931. A circular shows: Capitalization— Authorized. First Mtge. 5% Sinking Fund Gold bonds Outstanding. $5,000,000 $2,403,000 Capital stock 2,000,000 2,000,000 Purpose.—Proceeds will be used to reimburse the company for expendi¬ - enlargement and extension of property. Earnings—Years Ended— Dec. 31 '18. Dec. 31 *19. Oct. 31 '20. $1,024,866 $1,301,612 $1,530,575 347,684 410,935 636,523 Annual int. on $2,403,000 1st M. 5% requires 120,1553 Valuation.—Based on appraisal of independent engineers in 1914 (pre-war prices) plus additions ana improvements to Oct. 31 1920, the replacement value of physical property exceeds $5,000,000. Compare V. 107, p. 2192. — International Harvester Co —No Justification for Urg¬ the Reopening of the Government's Anti-Trust Suit.— Chairman Harold F. McCormick, commenting on the action ing of the Federal Trade Commission in urging that the Govern¬ ment's anti-trust suit against the company be reopened that competitive conditions can be restored, said: so Dec. 9.—V. 109, p. 1796. Keystone Tire & Rubber Co.—No Dividend—Earnings. The directors have decided to omit the quarterly dividned usually Jan. paid 1 in order to conserve cash resources and make it possible for the company to take advantage of present low prices of crude rubber and cotton fabric. Dividends of 3% have been paid quarterly from Jan. 1917 to Oct. 1920, incl. Stock dividends of 15% each, were paid in Dec. 1918 and in May and Sept. 1919. Statement of Income for Six Months Ended June 30 1920 (Latest Furnished) Gross profit on sales, $482,591; other income, $10,878; total.* $493,469 Selling, administration and general operating expenses 232,162 Interest, losses, etc 60,053 Dividends 3% quar (6%) 182,303 Balance surplus.. $18,951 The Balance Sheet, June 30 1920, shows (a) current assets, $4,951,632, incl. chiefly cash, $141,264; accounts and bills receivable, $4,108,249; merchandise inventory, $694,711; (&) current liabilities $1,256,394; (c) capital stock outstanding (no bonds) Pref., $100 Common $3,039,195; total, $3,039,295; P. & L. Surplus, $1,233,592 —V. 110, p. 365. King Motor Car Co., Detroit.—Sale.— tures incurred in the Gross earnings (incl. other income)— Net after maintenance & taxes Campello, Mass.—Obituary.— on Circuit Judge Marschner in the Wayne County (Mich.) Court on Dec. 13 granted a petition of the Union Trust Co., receiver, to Charles A. to sell the usiness, machinery and assets of the company for permission Finnegan of Buffalo, N. Y., for $500,000—V. Ill, p. 1666. King Philip Mills, Fall River, Mass.—Div. Decreased.— A quarterly dividend of 2% has been declared on the outstanding $2,250,000 Capital stock, par $100, payable Jan. 3 1921 to holders of record Dec. 20 1920. In October last, a quarterly dividend of 3% was paid, compared with 10 % in July last and 5% in March last. A 50 % stock distribution was made in Sept. last, increasing the outstanding stock from $1,500,000 to $2,250,000: this compares with a dividend of 50% paid in Liberty bonds in March last.—V. Ill, p. 1284, 1188. (S. S.) Kresge Company.—November Sales.-— i920—Nov.—i9i9. $4,651,861 $4,020,456 —V. 111. P. 2048, 1570. Increase. I 1920—11 Mos.—1919. $531,4051$43,421,836 Increase $36,0o6,309 $7,382,527 < Co.—25% Stock Dividend.— Libbey-Owens Sheet Glass Dec. 8 declared a dividend of $6 25 (25%) on each share of outstanding Common stock, payable in Common stock, at par, on Dec. 31 1920 to stockholders of record Dec. 21.—V. Ill, p. 2321. - The directors on Liggett's International, Chairman Louis K. You will recall Its actual sales figures. S37.000.000. months were in excess of $20,500,000. and with its largest volume months, Oct., Nov. and Dec., yet to come. I feel I am very con¬ servative in stating that the volume of sales will exceed $41,000,000. In our original estimated figures It was expected that the company would earn approximately 14% for its Common stock. I am of the opinion that this will be exceeded, and this after providing for an increase in English taxes not contemplated at the time of our original estimate." for its first six Compare United Drug Co. below.—V. Ill, p. 1088, 901. Incorporated.—Earnings—Dividend.— Loews, first Total admissions to theatres the 12 weeks ending Nov. 21 1920, or the Earnings statement for the current fiscal year, shows: quarter of operated, 17,564,149; gross box office receipts, $5,349,784: Loew's share of net profits after estimated Federal taxes amounted to $670,209, including estimated net profits of the Metro Pictures Corp. for four weeks. President Marcus Loew says in substance: "The peculiarly strong posi¬ tion occupied by this business is reflected in the fact that during the past few months, in the face of drastic reductions in most lines of business, the operations of the various enterprises of your corporation have shown a healthy increase over corresponding periods of previous years. Past experiences have shown that even in periods of severe financial and indus¬ trial depression low-priced amusement enterprises such as ours have con¬ tinued to do business profitably when most other businesses were at a standstill. There is every indication that the ensuing year will be one of continued and Increasing prosperity for Loew's Inc." The directors have declared the regular quarterly dividend of 50c. per share on the outstanding stock, payable Feb. 1 1921 to holders of record Jan. 15 1921.—V. Ill, p. 1756. (Canada),. Ltd.—Consolidation.— Loew's proposes immediately to acquire the real and following Loew enterprises in Canada, namely, Ltd., Montreal; Loew's Metropolitan (Montreal) Theatres, Ltd.; Montreal; Loew's Ottawa Theatres. Ltd., Ottawa and Loew's Windsor Tneatres. Ltd., Windsor. This consolidation it is said will include all the Loew above corporation The personal property of the Marcus Loew's Theatres, , (par $10) will be common on a and will be exchanged for the existing common basis of earnings. Co.—Capital Increase.— Lone Star Gas The stockholders have ratified the proposition to increase $10.000.000 to $11,000,000 anci to issue stock to stockholders at par. The new stock is from capital stock the additional .$1,000,000 to be paid for by Jan. 20, subscribe expires Dec. 18. Directors ore given the power to dispose of new stock not subscribed the stockholders as they may see fit.—V. 11}, p. 2234. ' ' and the right to McCrory Stores for by Increase. I 1920—11 Mos.—1919. $102,083 $12,086,556 $10,033,331 1920—Nov.—1919. $1,223,767 $1,121,684 1955. Increase. stock Com, and of 1% % on the Pref. stocks, all payable Dec. 31 to holders of record Dec. 24. An extra dividend of $2 per share has been paid on the Commofl 1918. The stockholders will vote Dec. 21 on increasing the stock to 54,000 shares, without par value.—Will, p. 1188. stock in each quarter since Jan. from 7,500 Preliminary Statement for Fiscal Operating profits Year ended Oct. 31 1920. $3,778,060 42,871 Add—Interest on current accounts.. ' Deduct—Taxes $3,820,932 $566,800 ; 7% dividend on Preferred Reserve for depreciation .... 245,000 stock (10%) 1,000,000 shares Dividends paid on Common 586.000 the year... at Oct. 31 1920. $1,423,131 $2,939,611 Balance carried to surplus for Balance in surplus account as - Colonos of the company, were $5,019,867, against current liabilities, $1,227,984.—V. 110, p. 2486, 2492. The current assets, including advances to Manning, Maxwell & Moore, Inc.—Extra Dividend.— been declared on the capital stock, along dividend of 1 J4%. both payable Dec. 31 to A like amount was paid extra in March last, An extra dividend of 1 34 % has the regular quarterly holders of record Dec. 31. compared with J4 of 1% In Feb. 1913 and 134% each in 1916, June 1918 and March 1919.—V. 110, p. 2662. Manufacturers' Light & Heat a Dec. 1915, June been declared on the outstanding Capital stock, par $100, in addition to a dividend of 2%, Jan. 3 1921 to holders of record Dec. 20—V. 108, p. 385. $2,000,000 both payable Metropolitan Edison Co., Reading, Pa —Bond Offering. —Iialsey Stuart & Co., New York, &e., are offering at 95.82 and int. yielding 8K% $1,000,000 Ref. & Improv. 8% 15- Gold bonds, Series A. A circular shows: Due Nov. 1 1935. Dated Nov. 1 1920. Int. payable M. & N. 1 in New York without deduction for Federal income taxes now or hereafter deducti¬ ble at the source not in excess of 2%. Denom. $1,000. $500 and $100 lied, all c* & r*). in or 1921 and part on any int. date, upon 30 days' notice, at 10734 ^ of 1% less per year during each year thereafter. Tax refund in Mass. and Penn. Free of Penn. State tax. Company.—Organized in Penn. as a consolidation. Furnishes electric light and power service in Reading and Lebanon, Pa., and 64 other communities, and supplies practically all of the current used by the Reading Transit & Light Co. At present time, about 70% of the gross earnings is derived from sale of electrical energy for power purposes. Population (est.) 500,000. Security.—Secured by a direct mortgage lien on all of the physical propertv now owned or hereafter acquired. Upon retirement or the 1st & Ref. bonds, due Aug. 1 1922 these bonds will be secured by a first lien on part of the property, and by a lien subject only to $2,614,500 of underlying bonds on the remainder. Valuation.—The replacement value of the property as of Oct. 31 1920 amounts to $11,198,238. The inclusion of investment in securities of affiliated companies gives an aggregate figure of $14,937,144, as compared with the total bonded debt outstanding with the public of $8,564,500. - Capitalization after this financing— Common stock Preferred stock 7% cumulative Metropolitan Electric Co. 1st 5s, due gage. Authorized. Outst .with public. $3,000,000 5,000,000 $3,000,000 2,500,000 1,000,000 4,950,000 1939 Closed 2,614,500 Issuance of additional bonds restricted by the provisions of the mort¬ (b) $5,200,000 1st & Ref. bonds will have been issued upon comple¬ Ref. & Improv. 8% bonds (this issue) __ First & Ref. 5% Gold bonds, due 1922 (a) , , Association owns approximately 66% of the 107, p. 1388. Missouri Utilities Co., Mexico, Mo.—Bonds Offered.— Chicago (111,) Trust Co. are offering at par and int. $250,000 1st Mtge. 8% Series "A" Gold Bonds. Circular shows: Dated Nov. 1 1920. Due Nov. 1 1935. Interest M. & N. in Chicago. Optional at 105 after May 1 1922. Denom. $1,000, $500 and $100. Chi¬ cago Trust Co., Chicago, and Jacob J. Frey, V.-Pres.Central National Bank, St. Louis, trustees. Company agrees to pay the Federal normal 2%. income tax up to j ... heating and and power earnings Company owns and operates the electric lighting, power, gas, water-works system in Mexico, Mo., and the electric lighting business in 11 additional towns within a radius of 25 miles. Net three times interest charges on all outstanding Mohawk Mining 1920—Nov.—1919. 760,567 1,033,322 Ill, p. 2048, 1666. bonds. Co.—Production {in Lbs.).— Decrease. I 1920—11 Mos.—1919. 272,755(9,190,460 11,837,488 Decrease. 2,647,028 Montreal Light, Heat & Power Harris Forbes & Co. are Mtge. & Coll. Trust ill,p. 2144. V. Co.—Bonds Offered.— $150,000 1st at 105.— offering at 81 and int. a block of 434s of 1902. Due Jan. 1 1932 but callable 1 Vernon-Woodberry Mills, Baltimore—New Notes. Trust & Deposit Co., Baltimore, Md., has purchased $1,Debenture notes dated Jan. 1921 and due Jan. 1 1922. Data from Letter of President Howard Baetjer, dated Dec. 8 1920Purpose.—The proceeds will be used to retire $1,000,000 6% notes Mt. The Mercantile maturing Jan. 1 1921. Security.—No mortgage debt may be placed upon the property during which together with the outstanding $500,000 6% due Jan. 1 1922 are secured on all of the property conservatively valued at $12,000,000, or 8 times the amount of the total outstanding notes. Quick Assets.—Upon completion of this financing, company will have an excess of current assets (cash, merchandise, goods in process, accounts receivable, &c.) over current liabilities, after setting aside Federal taxes, as well as proper reserves to cover losses arising from the decrease in the price of cotton and from cancellations, of more than $5,000,000, or over 3 times the amount of the outstanding notes. Company has a cash balance of over $1,000,000 at this time. Earnings.—Net earnings for the past 5 years, 1916 to 1920, will average in excess of $900,000. Int. on the outstanding notes, incl. this issue, amounts to only $90,000 p. a. Manufacturing Plants.—Company is one of the largest manufacturers of cotton duck and similar fabrics in the world. Property includes three groups of mills, situated in Baltimore, Columbia, S. C., and Tallassee, Ala, [Holders of the notes due Jan. 1 1921 were offered the opportunity up to Dec. 15 to exchange their notes for the new issue at 9834 and int. yielding about 7.85%J—V. Ill, p. 195. the life of these notes, notes Nashville (Tenn.) Gas & Heating Co.—Rate Increase.— Commission has authorized the company to increase this being an in¬ The! Tennessee P. U. subsidiary, has declared a 50% stock Ill, p. 2048. An extra dividend of 3% has and int. paid; none since. The Salt Creek Producers was stock —V. Co.Subsidiary Co. De¬ Maryland Coal Co. of W. Va .—Extra Dividend.— year of 234% holders of 50% Stock Dividend.— The Natural Gas Co. of W. Va., a dividend.—V. Oil Co.—Common Dividend No. 2.— 2% has been declared on the Common stock, along with a the Preferred stock, both payable Jan. 10 1921 to record Dec. 31 1920. In Jan. 1914. an initial dividend of 2% Midwest A dividend of dividend 000,000 one-year 6% Manati Sugar Co.—Earnings.— clares Miami Copper Co.—Decision.— U. S. District Court of Appeals, Philadelphia, has an opinion affirming the decision of the District Court of Delaware refusing to issue an additional injunction against the company to restrain it from all variations of the flotation process in treatment of its ore. After the U.S. Supreme Court decided the three patents owned by Miner¬ als Separation Co., Ltd., covering use of the froth flotation process in the concentration of ores were valid and have been infringed by Miami Copper Co., the Delaware Court Issued an injunction against further use of these processes by Miami, and ordered an accounting of damages to be taken before a master of chancery. In the course of this accounting it developed that Miami was using, according to testimony, eleven variations of appara¬ tus, and processes in flotation of its ores. • Contending that these were equivalents to the processes which Miami had been enjoined from using, Minerals Separation applied for further injunction against Miami. The present decision refers to this supple nental application. ("Wall Street Journal").—V. Ill, p. 2331. Judge Woolley in the filed Dividend to Inc. Stock. $2 per share has been declared on the Common quarterly dividends of $1 per share on the In addition to the usual with ! Mexican Eagle Oil Co.—New Stock.— Joseph Walker & Sons, 61 Broadway, N. Y,, yesterday reported the receipt of a cablegram from London stating that the company had officially announced its intention to offer shareholders the right to subscribe for one new share as to every two shares held by .them, respectively.—V. Ill, p. 1955. ; v:fcvy ■,:: /. —V. Magor Car Corporation.—Extra An extra dividend of __x$2,815,189 rentals and taxes. 855,557 Annual int. on total mortgage debt inci. this issue, requires 458,225 x Does not include any income of Pennsylvania Utilities Co. system, practically the entire common stock of which is owned. Increase in Earnings.—Since 1914, gross earnings of the company have increased 236%, and net earnings 109%. For the 12 months ended Oct. 31 1920, gross earnings of Pennsylvania Utilities System amounted to $2,139,238 and net earnings to $524,009.~V. Ill, p. 2234, 1857. Net after oper. expenses, over $2,053,225 Ended Oct. 31 1920. earnings (including other income) Gross Corporation.—November Sales.— —V. Ill, p. 2048, further bonds may be issued except upon pledge under said mortgage. Purpose.—Proceeds will be used to retire bond secured notes, due Dec. 15 1920, to reimburse the treasury for expenditures made and for other 1st & Ref. Ltd., Toronto; Loew's Montreal Theatres, enterprises in Canada execpt one in Hamilton. The new corporation is to guarantee the $600,000 Marcus Loew's Thea¬ tres, Ltd., 1st Mtge. 6% serial gold bonds dated July 15 1919 and will also create an new issue of $600,000 8% secured notes. The consolidated company, it is stated, will have an authorized capital of $20,000,000 of which $5,000,000 will be 8% pref. and will be issued to replace the present outstanding 7% issues. The balance $15,000,000 shares collateral tion of present financing, of which $250,000 will be deposited as under the mortgage securing the Ref. & Improv. bonds, and no corporate purposes. , Earnings for 12 months Ltd., Inc.—Sales.— Liggett says in substance: "The company is running true to its estimated that its first year's volume was estimated at [Vol. 111. CHRONICLE THE 2430 (a) (b) its rates for gas to $1.90 gross or $1.80 net per $1,000 cu. f.t, crease from the present rate of $1.20 gross and $1.10 net. Three estimates of the value of the property made by experts were; (1) Historical cost lass depreciation, $2,508,665. (2) Cost to reproduce new, depreciation based upon average prices for 1915-16-17-18-1919, $3,569,990. (3) Cost to reproduce new less depreciation based upon present prices, $4,655,380. The Commission ordered that the investment upon which a fair return shall be allowed to the company shall be $2,650,000 as less of April 1 1920.—V. 109, p. 277. Nashville (Tenn.) Industrial Corporation.—Purchase of Old Hickory Powder Plant from U. S. Government—Industrial Development Proposed.—This corporation, composed of busi¬ ness men of Nashville, Tenn., have purchased from the U. S. Government the "Old Hickory" Powder Plant at Jackson the navi¬ described XXIII of "Chronicle" for Aug. 14. ville, Tenn., located 12 miles east of Nashville on gable Cumberland River. This plant was fully on adv. pages XXII and An authorized statement just issued says in substance: The purchasers plan to develop this immense war undertaking into a large manufacturing centre, having available immense housing and manu¬ facturing buildings and facilities. , . . ^ „ The village had a population of 35,000 when the plant was closed in and is now completely equipped with all necessary public utilities, banks, club houses, &c., and offers many attractive inducements industries or those desiring a change in their location. | 1918 schools, to new manufacturing undertaking during the war, costing over $87,000,000. It occupies 5.100 acres of land, has a water filtration system capable of supplying a city the size of Boston, one of the largest steam power plants in the world, a double track railroad connecting with trunk lines, 35 miles of industrial track connecting manufacturing buildings, an immense refrigeration system, complete water works, sewer¬ age system, fire departments, concrete and macadam roads. A great quantity of surplus material in the manufaturing area will be dismantled This was the largest Government and sold. The officers are: _ President, H. G. Hill; V.-Pres., W. R. Tate; Director of Sales, Paul M. Davis; Sec., Nashville, Tenn. „ „ _ G." E. Bennie; Treas., B. P. Morse. Office, Dec. 181920.] THE CHRONICLE [Compare reiK)rt of E. I. da Pont de Nemours & Co. in V. 108, p. 1072; 106, p. 931.]—Y. Ill .p 1956. V. National Fireproofing Co.—" Christmas" Dividend.— v dividend of 1% has been declared ^J:J'?P0'522 deferred tj/Pt on stock, par $100, payable Dec. 31 dividends at the rate of 4% p. a. V60/ 2,3*- Quarterly ■ Ksafl rp?A, ^14. wWoiT the outstandto holders of were paid a bill in Salt Creek equity in the Federal Ill, p. 2332. An issue of £300,000 Offering.— 8% 5-year notes were recently offered in London Denom. £10, £50, £100 and £500. Red. at £115 on or before Sept. 1925. Capital issued and outstanding £1,500,000 par £1. No de¬ bentures or debenture stock. ..•• v:;,' The company was incorp. in England Dec. 31 1909 and through its Mexican subsidiairies operated successfully the Santa Gertrudis Mine in the Pachuca District of Mexico, having treated 2,572,602 short tons of ore at 98. 30 containing 184,647 ozs. gold and 34,259,517 ozs. silver resulting in an operating profit of £1,995,940. For the year ended June 30 1920, net operating profit after depreciation amounted to £361,600, 1919 £274,552, 1918 ■£213,407. -V..In 1919 was instrumental with others in forming the Mexican Corp., Ltd., and subscribed for £250,000 shares out of a total issued capital or £1,000,000. The Mexican Corp., Ltd., has secured through the medium of a local Mexican company (the Mexican Corp., S. A.) an interest in two important mining properties in Mexico, viz., the Fresnillo Co. in the State of Zacatecas, and the Teziutlan Copper Co. in the State of Puebla. F. W. Baker, Chairman 341 Salisbury House, London Wall, E. C 2. (Full details in the London "Statist" of Nov. 13, 1920.) ' ^ -. both old companies. disposing of the New York company's petition fixed as the fair value of its property on June 30 1919. Upon that basis the board found that the earnings of the company for 1919 yielded a return of more than 8%.—V. Ill, p. 1571. Nipissing Mines Co., Ltd,—Extra Dividend.—Cash,&c.— declared on the stock in addition to botn payable Jan. 20 1921 to holders July 1919, and in Jan. and Oct. 1920 Sears, Roebuck & Co.—February Dividend Assured.— Vice-Pres. A. H. Loeb says: "Feb. div. is as much assured as any div. be in the sense that, barring unforeseen contingencies, it will be paid. Nobody can foresee the future far ahead but we know enough about our figures to know this div. can be paid and to believe it should be, therefore can Lr Showing Total Cash,&c., $4,6,42.854. Cash In bank, incl., Canadian & XT. S. war bonds Bullion and ore in transit and at it will be paid in regular order unless something calamitous happens. "Business is about as poor as ever (Dec. business running 30% to 35% a year ago) and we have had scarcelj enough time yet to feel the benefits from cold weather, but we are hopeful still. —V. Ill, p. 2236. $3^323^584 $Sy38 smleter,&c. 1,319.270 1,623,000 Hugh Park. Mgr., says:"During Nov. company mined ore of an estimated value of $190,219 (as compared with $184,578 produced in Oct.—Ed.) and shipped bullion and residue from Nipissing and cuscoms ore of mated net value of $232,526. an less than Sheffield Iron Corp., N. Y. esti¬ The silver value of the month's production was estimated at 69c. per oz. compared with 82c. in Oct."—V. Ill, p. 1477, 1285. ";\/V;..>v^ ■ Producers Association, Inc.—Dividends.— Ill, p. 2322. same rates that were approved in the case of New York Telephone Co. r The Commission disapproved the application of the Delaware & Atlantic company to consolidate its property with the property of the New York company (the latter company owning or controlling the stock of the former) by the creation of a new company, which would take over the properties of Financial Statement district, will be located at Jersey City office will be discontinued.— Santa Gertrudis Co., Ltd., London.—Note £°mpany A? ma!le effective the the extra dividends of 5% each were paid. City> kut Santa Cecilia Sugar Corp.—Dividends Omitted.— a temporary receiver be appointed.—V. Ill, An extra dividend of 5% has been the regular quarterly dividend of 5%, of record Dec. 31 1920. In Jan. and £621,347 The regular quarterly dividends of 25 cents per share on the outstanding 105,000 shares of Common stock, no par value, and 1 %% on the Pref. stock, usually paid Feb. 2, will be omitted on that date. Owing to the unsettled conditions of the sugar industry in Cuba and elsewhere, and to the uncertainties of the financial situation generally," the directors believe that all dividends should be withheld until "the conditions referred to shall have righted themselves."—V. New Jersey P. U. Commission has approved a schedule of telephone charges put Into effect in Jan. and May 1919, by the Postmaster General in so far as they apply to the New Jersey district of the company. At the &ame time, the Commission dismissed a petition of the Delaware & Atlantic telegraph & Telephone Co. for various rate increases, but authorized the $34,700,000 • See Midwest Oil Co. above.—V. New York Telephone Co .—Rates—Consolidation Denied. The •oT^omraission,in lll°r St395*' V Co.—Receivership Sought. attorney has filed Decrease. £32,622,138 company announces the removal of Its general offices to the new plants located at Dixwell and Putnam Avenues, New Haven, Conn. The execu¬ Increase. stou' asking that 1956 P an 1377. 1920—11 Mos.—1919. £139,5841 £32,000,791 tive offices and sales office for the northeastern $1,522,000 New Idria Quicksilver Mining p. Safety Car Heating & Lighting Co.—General Offices.— The Cordelia Copper Co.—Production (in Pounds).— Percy A. Guthire Decrease.1 €2,740,250 £2,879,834 Ill, p. 2049, 1571. Pr°P®rty of the company located at Rochester, Nev., has been sold ? -Anglo—California Trust Co., trustee, to satisfy the bonded debt to aficenzie °f,?an Francisco. This is one of the properties that was to gf.juto tne consolidation recently formed and known as the Rochester cr Corp., the latter owning about 1,000,000 shares of Nenzel Crown Point stock.—(San Francisco "News Bureau.") 1920—11 Mos.—1919. $30,000.—Compare V. Ill, —V. Nenzel Crown Point Mining Co. —Foreclosure Sale.— $1,566,0001$38,130,000 $36,608,000 cost nearer Mines, Ltd.- -Valuations of Transvaal GoldJOutput.— 1920—Nov.—1919. . n $2,670.000 £4.236,000 ill, p.1956,1477. doubtedly Rand depend entirely upon the results of the future operations of the company."—V. Ill, p. 1088. —V. RR. in statement "Why the RR's are not large buyers of equipment" published in "Iron Age" of Dec. 16, p. 1628 j The 7,700 cars o^nt£n y tae company on Dec. 31 1919 cost it an average sum of about $17,500 each (the book value however allowing for depreciation reserve being about $9,500) but at the present time these cars new would un¬ for ®tock from Jan. 1910 to Jan. 1915, incl.; none since. * Keasbey sajs: "The year 1920 has proved to be one of the eerupany's history and the stockholders should participate in it. nif ° n°t be construed as meaning a resumption of dividends, Decrease. | 2431 Vice-Pres., Penn. y'Yr'H-Vv'cV Northwestern Power Co,—Dividends Resumed.— : City.—Receivership.— Judge Knox on Dec. 17 appointed Roger S. Wood and James L. Weeks receivers for this company, with offices at 71 Broadway, on the petition of Harbison-Walker Refractories Co.—V. 110, p. 2392. ; , dividend of 3% has been declared on the outstanding $3,600,000 Preferred stock, par $100, payable Jan. 1 1921 to holders of record Dec. 20 1920. A dividend of lj^% was paid on the Preferred in July 1916; Jan. 1917, 4H%;andin July 1917 a semi-annual dividend of 3% was paid; none since.—V. 107, p. 408. ^ Sheridan-Wyoming Coal Co., Inc.—Dividend No. 2.— The second dividend of $ i .25 per share has been declared on the Common stock, no par value, payable Jan. 10. An initial dividend of like amount was paid in Oct. last. All of the stock of the company is owned by the United States Distributing Corp.—V. Ill, p. 1190, 1089. Northwestern Yeast Co.—Usual Extra Dividend.— Southern Counties Gas Co. of Calif.—"-Bonds Offered.— Gervin & Miller, San Francisco, are offering $400,000 10-year Collateral Trust 8% Gold bonds. Autli. $1,000,000. O-Cedar The bonds are convertible into long term 1st Mtge. 5H% bonds at par for 85 for the first 5 years, and par for 90 for the last 5 years, giving a yield for the 1st Mtge. 5H% bonds, under the convertible privilege, of from 6.90 to 7.60. ' An extra dividend of 3% was payable on the stock Dec. 15 to holders of record Dec. 12, along with the regular quarterly dividend of 3%. An extra dividend of 3% has been paid quarterly since Sept, 1914.—V. Ill, p. 1189. Co. _ Mills Co.—Connection Severed—Guaranty on with Channell Bonds Amply Protected.— See Channell Chemical Co. above.—V. Chemical Ill, p. 994; V. 110, p. 2082. — For the year ending Oct. 31 1920 bond interest, plus the int. require¬ ments of th'ff present issue, is $332,363 while net earnings were $626,896. The Toronto Stock Exchange has authorized the listing of the company's securities as follows: Common stock, $2,000,000; Preferred stock, $750,000, bonds $600,000.—V .111, The new $400,000 8% bonds are secured by deposit with the trustee of $525,000 1st Mtge. 5H% bonds, which, in turn, are secured by ail absolute 1st Mtge. on all the property of the company.—V. Ill, p. 2145. : Ontario Steel Products Co., Ltd.—Listed at Toronto P.J799. , __ Pacific Development Corp.—Rights to Additional Stock.— The Stockholders of record Dec. 20 are given the right to subscribe on or before Jan. 10 1921 at $25 per share to 64,388 shares of capital stock (no par value) to the extent of one new share for each four shares held. Com¬ pare V. Ill, p. 2144, 2331. Pacific Portland Cement Co.—Extra Dividend. Extra dividends totaling 3% p. a. were ncl.—V. 108, p. 84. monthly dividend of paid from 1917 to 1919 Paragon Refining Co.—Earnings—New Director.—- Net profits, after taxes and other expenses, for the fiscal year ending Oct. 31 1920 were $1,515,963; gross profits were $12,108,627. h P. J. Hurley, Vice-President of the Gilliland Oil Co., has been elected a director.—V. Ill, p. 1285. (J. C.) Penney Co.—November Sales.— 1920—Nov.—1919. $4,975,546 $3,23^,313 Ill, p. 2049, —V. Increase. I 1920—11 Mos.—1919. Philadelphia Increase. $1,742,2331$37,718,645 $25,479,776 $12,238,869 1667^. Ga3 & Electric Co.— It appears that in May last the company arranged to issue $800,000 7% Cumulative Pref. Capital stock, part of a total authorized issue of $25,000,000 (none of which had theretofore been issued) and to turn the same over to the American Gas Co. (owners of all the outstanding capital stock) in exchange for this company's $800,000 outstanding 6% Cumulative Pref. stock.—V. 110, p. 83. ' of 23^%.— t """Pond Creek Coal Co.—Extra Dividend ^ ■ An extra dividend of 2lA % has been declared on the outstanding $2,129,par $10, in addition to the regular quarterly dividend of 2H%, both payable Jan. 1 1921 to holders of record Dec. 24 1920. Divi¬ dend record: Initial quarterly dividend of 50 cents per share (5%) paid in Julv 1917, which rate was maintained to and including Oct. 1918; 3%% in Jan. 1919; April 1919 to Oct. 1920, inclusive, 2Yx% quar.—V. Ill, p. 2145. 200 Capital stock, """Prairie Oil & Gas Co.—Extra Dividend.— An extra dividend of $3 per share has been declared capital stock on $18,000,000 an $5 In April last, $7 in Jan. last; in Jan. and Oct. 1919; extras of $5 each and 1 April and July 1919 $2 each.—V. Producers Results for & Refiners Ill, p. 1190. Corp.—Earnings, &cJ— 1920 without Taking into Account Depreciation and Depletion. Gross Inc. Expenses. Net Income. $629,555 $196,335 $433,220 October 1919 408,790 205,968 202,822 Net income in 1920 by months; June, $407,030; July, $412,469; August, $419,389; Sept., $430,285; October, $433,220-—V. Ill, p. 2145.. October 1920——* , — Pullman Company.—New Cars.— "The Pullman Company is building 500 Pullman cars this year, none having been built during the period of Federal control." [Geo. D, Dixon, Standard Gas Co., Atlantic Highlands, N. J.—Comm. no Power over Rates when Company is in Receivership.— has Vice-Chancellor Backes of New Jersey, sitting in Newark on Dec. 8, asserted that the Chancery's prerogatives in case of a receivership supersede the jurisdiction of the P. U. Commission. He directed the receiver of the company to ignore the Commission's order suspending increased rates until March 1 and put them into effect at once. He also directed the Board to rescind its order interfering with the receiver's schedule.—V. 108, p. 282. Standard Oil named Co. below and int. $25,000,000 Bankers (Calif.).—Debentures this week Offered.—The offered and sold 100 at 10-year 7% Gold Debs, (seeadv. pages); Making Offering.—Wm. A. Read & Co., New York; The Anglo & London Paris National Bank of San Francisco, Continental and Com¬ mercial Trust & Savings Bank, Chicago; Blair & Co., Inc., and Equitable Trust Co., New York. . „ . Dated Jan. 1 1921. Due Jan. 1 1931. Int. payable F. & A. in New York and San Francisco. Denom. $1,000. Red. as a whole on any int. date on 30 days' notice at 105 and int., if redeemed on or prior to Aug. 1 1921, and thereafter at M of 1% less for each half year, or part thereof, elapsed after Aug. 1 1921. Equitable Trust Co., New York and Anglo-California Trust Co., San Francisco, Trustees. , Data From Letter of President of Company to the Bankers Company.—Is producing from its own wells in the United States over 100,000 bbls a day, and as such is the largest producer of crude oil in this country and is one of the largest lefiners and distributors of petroleum and its products in the world. the (par $100), along with the regular quarterly dividend of $3 Ser share, both payable Jan. 31 1921 compared with $3 extra 21 July last, ct. last extra of $5 was paid, to holders of record Dec. in 1920. In In Ninety-three ($93,000) First Mtge. 6% 20-year sinking fund gold bonds at par and int at the of 1907 have been called for payment Jan. 1 1921 Girard Trust Co., Phila., trustee.—V. Ill, p. 800. bankers , Suburban Go.—Preferred Stock Increased— Spanish-American Iron Co.—Bonds Called.— An extra dividend of 1% was paid Dec. 5 last on the outstanding $6,000,000 capital stock, par $100, In addition to the regular H of 1%. Southern Power The company has filed a certificate in New Jersey increasing the author¬ ized Preferred stock from $6,000,000 to $10,000,000, par $100. There is outstanding $4,000,000 of an authorized issue of $5,000,000 Common stock, par $100, and also $6,000,000 Preferred stock.—V. Ill, p. 1957. Security.—Will be direct obligation of company which has issued no mort¬ During the life of these debentures company having priority over this issue. Market Equity.—Company has outstanding $99,373,310 common stock* at present quotations representing a market equity of about $320,000,000. Sinking Fund.—A nually, $500,000 commencing Jan. 1 1922, for the purchase of these debentures at not over 100 and int. and If not so purchas¬ able during the year, to revert to the general funds. Maintenance of Quick Assess.—Company must at all times maintain quick assets equal to 150% of the outstanding debentures. • Property Valuation.—The depreciated replacement value of the company s assets, including its properties in Calif., Ore., Wash., Alaska, Nev-, Ariz., Colo., and the Hawaiian Islands, and excluding its assets in the Philippines and Central and South America, according to an appraisement now being completed by Ford, Bacon & Davis, will exceed $400,000,000. Earnings.—For 1919 net income after Federal taxes, etc., was equal to about 18 times int. requirements on this issue and for the past 5 years average net income equal to over 10 times int. on these debentures. Earngage and has no funded debt. must not issue any .obligations , , ings for the 10 months ending Oct. 31 1920, are In excess of the earnings for entire year 1919. (Compare V. 110. p. 1080.) Dividend Record.—Company has paid regular cash dividends of not less since 1912. This year cash divs. of 14% have been paid. % was paid, incl. 2H % in U. 8. Liberty bonds. In addition, declared from time to time. Purpose.—Proceeds will be used to provide funds tor its 1921 program of extensions and improvements, incl. additions to its marine equipment, enlargements of its refineries and acquisitions of oil producing properties; also to increase working capital. [See Annual Report for Calendar year 1919 In Y. 110, p. 1080.]—V. Ill, p. 1758. 10% than p. a. In 1919, 13H laree stock dividends have been Standard Oil Co. of Indiana.—New Director.— V director succeeding Seth C. Drake. Jackson was also elected Fifth Vice-President in charge of sales;— Allan Jackson has been elected a Mr. V. Ill, p. 2332, 2236. Dated Jan. 2 1921, due Offered.— Read & Co., Equitable Trust Co., Blair & Co. and Wm. A. thi 8 week offered and sold at 100 and int., 7% Serial Gold Debentures. $30,000,000 $4,000,000 each Jan. 2 1925 to 1930, inclusive, $6,000,000 Jan. 2 1931. Denom. $1,000, $500 and $100 (c*). Red. all of part on any Int. date on and after Jan. 2 1925 at 105 and int., if less than the entire issue should be called for redemption, the longest outstand¬ ing maturities to be called first. Int. payable J. & J. at office of Equitable Trust Co., N. Y., trustee, or Blair & Co., Inc., without deduction for Federal Income tax not exceeding 2%. and Letter of President H. C. Folger, Dec. 15 1920. Security.—The direct obligations of company and will constitute its sole The indenture provides that company will not create any mortgage on (except purchase money obligations) or pledge of its properties unless the debentures shall be equally secured. Earnings.—Net earnings for 1920 before Federal taxes are estimated at $60,000,000. Net earnings before taxes for the four years ended Dec. 31 1919 averaged 20 times the annual Interest on these debentures, and for 1919 were nearly 28 times such annual interest (for 1919 see V. 110, p. 2083). Equity.—Has outstanding $75,000,000 capital stock on which dividends of 16% p. a. are being paid. At present quotations stock represents an equity of about $250,000,000. Current Developments.—Is engaged in adding to its refinery capacity, marine equipment, &c., the earning capacity of which expenditures, and of the proceeds of this issue, will be reflected in future operation. Capital requirements have been supplied almost entirely from earnings. In the fire years ended Dec. 31 1919 about $115,000,000 from surplus earnings have been reinvested in the business. funded debt. Comparative Balance Sheet. [1919 Inserted by Editor.] June 30 '20. Dec. 31 '19. $ Dec. 31 '19. June 30 '20. $ Liabilities— Assets— 75,000,000 75,000,000 162,916,406 142,583,873 Capital stock... Real est., plants, J Surplus vessels, Ac... 99,224,294 85,969,617 13,204,575 114,722,993 U. S. Lib. bonds 19,664,272 3,554,551 Res've for insur., 98,232,303 bad debts, Ac. 33,781,937 Res've for Fed'l 78,054,182 Current llabil's. Deferred assets. Inv. of mdse Cash A 78,987,493 325,803,628 299,592,590 Total —V. taxes current assets Standard Parts Co., Sufficient progress has been so 9,301,533 Total 15,165,067 70,305,114 (est.) 7,863,493 58,980,157 325,803,628 299,592,590 Cleveland.—Amend Plan.— made in the reorganization financing, it is effort will make the that one more determined, co-operative An extension of time to Dec. 17 has been granted by the Court in order that stockholders may make up the difference that still exists in the amount of money they have been asked to raise. Investment dealers, brokers and many of the banks have expressed a willingness to work together to push the deal to successful completion in order that the large plant may be saved. The stockholders have been ad¬ vised that up to Dec. 7 the amount subscribed by them aggregated $1,830,000. The sum they are required to subscribe is $2,000,000. With that done, the investment dealers and brokers through an amended program hope to arrange for sufficient funds to lift the company from receivers' hands. An amendment to the plan provides for the increasing of the amount of prior lien stock from $3,000,000 to $4,200,000, while the amount of Class A Preferred was reduced from $6,500,000 to $5,300,000, making the total $9,500,000. (By Guy T. Rockwell in Cleveland "Plain Dealer.") Com¬ pare V. Ill, p. 1758, 1957. plan operative. Screw Co.—Dividend Reduced.— dividend of 5% has been declared on the outstanding $3,500,000 Common stock, par $100, payable Jan. 1 1921 to holders of record Dec. 18 1920. Quarterly dividends of 6% were paid from July 1917 to Oct. 1920 incl. A special cash dividend of 20% and a 40% stock dividend Standard A quarterly were last.—V. Ill, also paid in October Suncrest Lumber p. 1089, 996. Co., Sunburst, N. C.—Tenders.— The Union Trust Co., 7 So. Dearborn St., Chicago, will, until Feb. 2 1921, receive bids for the sale to it of Series "Bll" Second Mtge. 6% gold sonds of 1918, to an amount sufficient to exhaust $10,557, now in the sinking fund. Sunday Creek Coal Co. of Ohio.— Chairman, has purchased all Pres. This is the result of negotiations which have been going on for some time. A year ago Mr. Winder brought suit for a settlement of certain stock and an accounting, but was defeated in the courts. Mr. Winder resigned as President July 18 and Harry B. Arnold was elected in his place. The present board is composed of J. S. Jones, C. C. Cook, George K. Smith and Harry B. Arnold. At the same time announcement was made that Mr. Jones has disposed of his interest in the F. C. Stedman Co., of Athens, a store concern, which has been taken over by Mr. Winder. "Coal Trade Journal."—V. 108, p. Swan & Finch Co., 1724. New York.—Pref. Stock Offered.— The Common stockholders of record Nov. 10 are offered the right to sub¬ scribe at par ($25) to 18,062 shares of new 8% Cumulative Pref. stock on the basis of one share of pref. for each share of common stock of $100 par value held. On or before Dec. 24 warrants will be mailed to stockholders subscriptions are payable in New York funds at the Columbia Trust Co., 60 Broadway, N. Y. City, on or before March 1 1921. The authorized amount of pref. stock is $1,000,000 and the authorized outstanding. Compare common V. stock $4,000,000, of which $1,806,200 is Ill, p. 1748, 1849, 1957, 2050. . Fruit Products Co.—Company's Divi¬ Deferred—Official Statement.—The directors on Dec. 14 announced that the quarterly dividend payment of $1 per share on Class "A" and Class "B" stock had been deferred. Temtor Corn & dends The statement issued by the board says in substance: Earnings.—The earnings for the ten months ended Oct. 31 1920, after charging off all expenses incidental to organization and setting aside $50,000 for Federal Income tax payable in 1921 and $47,394 for losses in inventory, $1,701,604 surplus as of Jan. 1 1920, made a surplus as of Oct. 31, before deducting dividends, of $1,810,400. Dividends paid during the year on Best-Clymer Preferred and both classes of Temtor stock amount to $816,825, leaving a [profit and loss] surplus as of Oct. 31 amount by any material declines, and the company was particularly for¬ cleaned out of sugar when the drop occurred in that com¬ Stocks on hand at the Granite City plant when it was taken over in Oct. 1920 were accepted at their market value as of that time, a time when prices were at a low ebb. Higher Freight Rates Affect Competitors.—Freight rate Increases have put competitors from 10 cents to 15 cents a case out of line in the large terri¬ tory tributary to St. Louis and statistics show that this is the largest con¬ suming territory in the United States. [Signed M. G. Clymer, President.] —V. 110, p. 1297, 1194. affected tunate in being modity. Teziutlan Copper Co.—Santa Gertrudis, Co, Acquires Int. to___ This amount, added to the $993,575 Dividends.—Although the earnings of the company would justify the declaration of the usual dividend, the board believes in view of existing unsettled conditions in this country that it is best that the resources should be conserved and that, therefore, the quarterly dividend should be deferred on the Class "A" and Class "B" stock. The regular dividend of 1H % has been declared on Best-Clymer Preferred payable on Dec. 31 to stockholders of record on Dec. 28. Operations.—The Davis St. plant is running full capacity, with plenty of orders ahead. It will take until February to clean them up and pros¬ pects for new business are getting brighter every day. The Granite City plant is running 50% capacity but prospects are good that it will be running of full time within the next few weeks. Ltd., above. Tiffany & Co. (Jewelers).—History, dec.— Latest recorded sale of stock of Tiffany & Co., which has recently in¬ par value to 12,000 autcion for $6,500 a creased its capitalization from 2,400 shares of $1,000 shares of no par value, was in 1912, when block sold at share. It has always beenl very closely held. Charles Lewis Tiffany, founder, came to New York in 1837, and with John B. Young, borrowed capital of $1,000, established a stationery and fancy goods store at 259 Broadway; gradually the jewelry business became important; in 1847 manufacture of gold jewelry was begun. A year later, the price of diamonds dropped 50%. Tiffany sent word to his partner, then in Paris, to buy all the diamonds he could. Young bought, and the firm made a fortune. In 1851 the firm name was changed to Tiffany & Co. and branch established in Paris. In 1868 the firm was incorporated and two years later moved to Union Square. In 1870 a branch was opened in London and a watch factory in Geneva. Present location at Fifth Ave. and 37th St., N. Y., has been occupied since 1905. Profits have been large and dividends conservative. Dividends in recent years have been paid as follows: 1914, 35%; 1915, 25%; since then, 50% each year. Earnings have been much larger than dividends. For the fiscal year 1920 they were reported as $2,311,273, or practically 100%. ("Boston News Bureau.")—V. Ill, p. 2333. Toronto Electric See Toronto Railway Light Co., Ltd.—Proposed Sale.— 108, p. 2336. under "Railroads" above.—-v, Toronto & Niagara Power Co.—Proposed Sale.— under "Railroads" above.—V. 95, p. 301. See Toronto Ry. Toronto Power Co., Ltd.—Sale of Properties.— "Railroads" above and compare V. Ill, p. See Toronto under Trumbull Steel Co., Warren, An extra dividend of H of 1% 2333. O.—Extra Dividend.— has been declared on the Common stock, 1 Sar $25,1921addition to the regular Dec. 20 1920. Extra2%, both payable in to holders of record quarterly dividend of dividends of 1% an. was paid in Jan.. April and July last and also in paid in Jan. 1919. It is reported unofficially Ill, p. 1573. April 1919, while 2M% that H of 1% was paid in October last.—V. Union Ba& & Paper Corp.—Dividends for 1921.— authorized the creation of a fund of $1,200,000 for of payment of dividends in 1921 at rate of $8 per share on $15,000,000 capital stock outstanding. The company's business outlook, the officials believe, warrants the setting aside of this amount in order to continue the present dividends on the shares.—Y. Ill, p. 2237. The directors have the purpose United Drug Co.—Sale of $7,500,000 Six Months9 Notes Notes—Status—Balance Sheet.— The company has sold to Kidder, Peabody & Co., F. S. Moseley & Co. and Chase Securities Corp. $7,500,000 6 Months' notes, payable in New York, discounted at 8 %. -—Convertible Into 6- Year 15 1920, maturing June 15 1921. Convertible at any tune 1921 Into 8% notes dated Dec. 15 1920, maturing June 151926 Dated Dec. up to June 1 and bearing int. from June 1921. Notice of such conversion must be given, however, by the bolder of any note on or before June 1 1921. Coupon notes, $1,000, interchangeable into registered notes. Int. payable J. & D. Sinking Fund.—Sinking fund of 7% of the amount of notes issued will be set aside beginning Dec. 15 1921 to retire notes by purchase in the open market up to 105 and int. Thereafter each year, on Dec. 15 until the maturity of the notes, such sum as has been expended in the purchase of these notes in the previous year shall each year there shall be available 7% be added to the sinking fund, so that of the amount of notes issued for the purchase of these notes at the above price and interest. Safeguards.—Company will covenant through an indenture with American Trust Co., Boston (a) that no mortgage shall be put on any of the property except after acquired property during the life of these notas. without In¬ cluding these notes; (ft) that it will maintain at least 125% of quick assets in proportion to its floating debt, accounts payable, and debenture notes and (c) in case quick assets fall below this figure the company will stop payment of the dividends on the Common stock until this ratio is restored. Data from Letter of Pres. Louis K. Liggett, Boston, Dec. 10. Business.—The company's business is unparalleled and unique. In its laboratories and factories in Boston, New Haven, St. Louis and modern places it produces drugs, pharmaceuticals, toilet preparations, rubber goods, hospital supplies, and a variety of other merchandise required by drug stores. These products are protected by trade-marks and distributed chiefly through its 8,000 stockholder agents, called Rexall stores, situated in nearly every place in the United States of over 1,000 population, and also through 222 Liggett's drug stores, of which all the capital stock is owned. Boots Company.—Operates a large manufacturing establishment and 632 retail stores in England; was bought by Liggett's International, Ltd., Inc., and is doing a very profitable business exceeding $40,000,000 p. a., and other The company announces that J. S. Jones, of the interests of John H. Winder, former and other concerns in the same were 8,280,574 Ill, p. 995. believed, affected more than any o ther product which the handles, but the directors believe Temtor is better off than any line, some of which are shut down. Inventories.—Raw stocks are inventoried at a figure which will not be Syrup.—Syrup has been company See Santa Gertrudis Co., Standard Oil Co. of New York.—Debentures Data from [Vol. 111. CHRONICLE THE has turned out a most fortunate 1 purchase. New Plants.—During the past year we have built in St. Louis a new manufacturing plant equalling our present plant in Boston, a new rubber plant at New Haven, and a new fruit syrup plant in Boston. These were all demanded by the increased growth of the business, and will all, through the more economical handling of the business, furnish additional profits. Purpose.—These notes are issued to take care of notes payable caused by the growth of our business; proceeds, together with natural liquidation during the next 6 months, should substantially accomplish that result. 1917. 1918. 1919. 1920 (Dec.est.) :__$40,716,290 $51,028,336 $58,338,834 $70,000,000 3,156,007 4,579.922 5,275,004 Figures for 1920 do not include the volume of business or the profits of Liggett's International, Ltd., Inc. (see that co. above). Said company, whose entire voting stock Is owned by the United Drug Co., operates not only the Boots Co. in England, but a profitable manufacturing and retail Earns. Cal. Years— Sales __ Earns, (before Fed. tax.) business in Canada as well. Business for 1920 to date has shown an increase in excess of 30%; during the so-called dull months of Sept., Oct. and Nov. it has continued at this rate [1919 Inserted by Editor.] Balance Sheet Sept. 30. 1920. 1920. 1919. $ Assess— $ 5,470,378 Impts. A leaseb'ds 2,483,385 Fum., mach., Ac. 7,646,612 Real est. Abldgs.. Liabilities— 2,742,539 1,585,832 5,554,321 788,300 2,009,900 companies 6,378,014 Pat., tr.mks., Ac.21,877,365 2,278,357 Common Accounts stock 7,677,192 Notes receivable.. payable 4,694,838 Notes 4,019,741 Stock of allied cos. 411,043 Total —V. Ill, p. 78,460,508 57,181,803 1378. Total United Profit Sharing Corp., A semi-annual dividend of 14,095,780 595,000 436,300 2,635,184 115,770 5,511,117 78,460,508 57,181,803 N. Y.—Extra Dividend.— of 5% have been declared on 25 cents), both payable Jan. 15 1921 to In June last an extra of 5% was paid. 5% and an extra the outstanding capital stock (par holders of record Dec. 23 1920. 2,522,762 29,411,900 27,990,500 payable. 7,637,609 3,003,264 stock 716,200 155,048 Deprec'nreserve.. 2,987,371 Bad debts reserve125,149 Liberty bonds 66,078 606,850 687,846 Inventories at cost 22,187,312 12,489,668 Other reserves 5,265,453 Adv. A defd items 1,984,773 941,217 Surplus Accts. receivable.. % 472,906 11,889,100 Second pref. 1,471,671 22,920,078 1919. First pref. stock..16,221,900 do subscrip Holdings In outside Cash $ 523,000 Real estate mtgea. Dec. 181920.] compared with 15% extra in Dec. 1919 and 5% in June 1919 and Dec. 1918. —VT 111, p. 1958, 1573. U. R. S. company has opened 14 stores in N. Y. City, one in Philadelphia and one in Newark, and is doing in these 16 stores an annual business of over $3,000,000. The company states that other stores will be open this week in these cities. [The United Retail Stores Candy Co., Ltd., was incorp. in Canada under Companies Act, in Nov. 1920, with a nominal capital of $1,000 (par $100.1—V. Ill, p. 800. 700. 2.— A dividend of $1 per share has been declared on the outstanding $5,000,000 Common stock, par $50, payable Jan. 15 1921 to holders of record Jan. 3 1921. See An initial dividend of like amount was paid in October last. Sheridan-Wyoming Coal Co. above.—V. Ill, U. S. Food Products Corp.—No The directors 1190, 1090. p. dividend of % usually paid Jan. 15. United States Realty & Improvement Income Account for November and Seven Months 1920—Nov.—1919. Gross profit Net $662,657 $448,815 49,708 _____ Net income $221,511 $113,679 49,708 $399,107 earnings Debenture bond interest- $63,971 No dividends have been paid since Feb. Co.—Earnings.— ending November 30. 1920—7 Mos.—1919. $2,338,553 $1,458,963 $1,451,422 $789,043 347,958 347,958 $1,103,464 $441,085 Capital stock is $16,162,- 1915. 800.—V. 110, p. 2656. United States Trucking assume his duties been made. The strengthened by ratio of approxi¬ this program. At the present time quick assets are in the mately two to one of liabilities. Authoritative Statement "New from Tribune," York Dec. 11. Liabilities.—Current liabilities on Nov. 30, including bank loans, accounts.payable, trade acceptances and obligations to note brokers, stood at approximately $26,750,000. This marked a reduction of about $18,000,000 as shown by the balance sheet of April 30 last. 4 An arrangement has been made with banks holding the company's obli¬ gations by which at least part of these debts will be liquidated in an orderly way When conditions are more favorable it is believed that the remaining bank loans will be refunded by some sort of security. Assets.—Total assets of the Willys-Overland Co. on Nov. 30, exclusive of good-will, patents and deferred charges, amounted to $125,000,000. Cur¬ rent assets on that date were close to twice the amount of current liabilities, compared with a 1.3 to 1 ratio on April 30. Of our current assets approxi¬ mately $4,500,000 consists of cash.Business.—Our business has fallen off along with other automobile com¬ panies, but figures at hand show the volume of business don by our re¬ tailers last month was about 65% of normal. Including cars sold by deal¬ ers and those exported, the number of our cars moved last month was about 5,000. The personal affairs of John N. Willys are in no way involved in the obligations of the Willys-Overland Co. Mr. Willys has made it a policy for several years never to give his personal indorsement to a note of his company, and his stock market operations, at no time important, would if liquidated at the present time show a balance in his favor. See V. Ill, p. 2334. Corp*.—New Chairman.— The Governor says: Jan. 3 1921. on establishment of the utmost manufacturing and mer¬ To that end several changes in executive personnel have financial position of the company has been considerably Winnisimmet Shipyards Governor Alfred E. Smith has been elected Chairman of the Board, and will and chandising efficiency. . Dividend.— Dec. 16 decided to omit the quarterly See V. Ill, p. 2333. on Until the period of readjustment in the motor industry now in progress has been completed and abnormal credit conditions relieved the company will pursue a conservative manufacturing programl ooking toward reduction of inventories Candy Stores, Inc.—Stores in Operation.— l-r»JlfJn5e,*£?,y ^ last» United States Distributing Corp.—Dividend No. 3433 CHRONICLE THE trucking corporation brought out and merged the business and equipment of 28 of the largest trucking firms existing in Greater New York. a result, it has more than 2,000 employees, 2,500 horses, 2,000 trucks, 300 motors, immense equipment for stevedoring work, the hauling of struc¬ tural steel and building materials, and other special facilities fitting it to handle everything from needles to locomotives. "My association with the Trucking Corporation involves a personal association also with the controlling interests of the United States Dis¬ tributing Corp., which also owns the Sheridan-Wyoming Coal Co., Inc., one of the largest coal mining companies in the West, and the Tongue River Trading Co., which does a substantial merchandising business in the same territory." * On the directorate of the Distributing Corporation are: George F. Getz, its President, and Frank S. Peabody, two prominent Chicago business men, as well as Harvey D. Gibson, President of the Liberty National Bank, Grayson M. P. Murphy, Vice-President of the Guaranty Trust Co.: E. V.R. Thayer, President of the Chase National Bank; and H. E. Ward, President of the Irving National Bank. Capitalization: Authorized and outstanding, 20,000 shares of Pref. stock, par $100, and 80,000 shares of Common stock, no par value. See the United States Distributing Corp. and also the Sheridan-Wyoming Coal Co. above.—V. Ill, p. 1090. "The Co., Inc., Chelsea, Mass.— E. K. Arnold and W. R. Green, receivers, have been given permission by the U. S. District Court to issue $50,000 receivers' certificates at not more than 7%.—V. Ill, p. 2237. As Utah-Idaho Sugar Co —Dividend Omitted.— regular quarterly dividend usually paid Dec. 31 will be omitted on The company has been paying quarterly dividends of 2% from March 1920 to Sept. 1920; this compares with a quarterly of 3% paid in Dec. 1919 and 1^% each paid in June and Sept. 1919.—V. Ill, p. 80. The that date. Wolverine 195,379 —V. Ill, were paid in April, July and October last, making total dividends paid during 1920 $4 50 per share. President J. Leonard Replogle, Dec. 15, said in substance: "While earnings were in excess of the previous dividend requirements and cash position as strong, it was deemed advisable in view of the general condition of business to conserve the cash resources of the company so as to permit continued heavy shipments of ore from Peru, which will put the company In a particularly strong position to meet future normal demands."—V. Ill, p. 500, 80. ! permission to issue $2,000,000 5-year 7H% gold notes to be redeemable at prices ranging from 103 after the second year to 101 after the fourth year.— V. Ill, p.1958. i In a large majority of creditors have agreed to the extension indebtedness, as requested by the committee. Sullivan, Secretary of the Committee, has been elected Treas¬ urer of the company, succeeding Isaac S. Smyth, who remains as VicePresident. See plan in V. Ill, p. 2146. Yukon Gold Co.—Tin The shareholders voted Dec. 9 to increase: (a) the 50,000 shares of stock value each to 250,000 shares of no par value, of which each will receive two new shares, ho par value, for each share held; (6) to authorize the issuance of 50,000 shares ratably at an early date to the then shareholders on favorable terms, to provide for the cost of new extensions recently made and new machinery recently purchased, and also to provide- additional working capital. The remaining 100,000 common shares will only be issued when it may become necessary or advis¬ able in the company's interests. The shareholders also approved the moving of the head office from Montreal to Three Rivers, Que.—Y. Ill, p. par present shareholder of $100 par 1861. • ■; White Eagle Oil & quarter ending— Earnings before taxes, —V. Ill, p. 1090. Oil Refining Co.—Earnings- deprec'n and depletion.. Account for Harris Forbes & Co., discussing the application of the Water Power to the fact call attention Sept.30'20. $6,793,815 Net earnings .$1,355,069 Total misc. income (net)102,997 -- been filed with the new all the June30'20. $4,082,523 $1,220,721 51,685 donths. projects acted upon in all their history by the three Government "Development unavailable opening his up Mar.31'20. QMonths. $2,182,628 $13,058,966 $90,840 $2,666,631 20,727 175,409 $1,272,406 $111,567 $2,842,040 86,367 43,905 281,603 profit (inv. at cost) $1,306,735 $1,186,039 $67,662 $2,560,437 net - Net Add—Excess of market value over cost storage on of inventories of oil in tremendous scale of hydro-electric powers heretofore practicable through Important and most the — $3,521,168 eliminated. The company's subsidiary, the Crown Oil Co., with refineries at Pasa¬ dena Cal., and in Texas, has contracted to delivery during the year 1921 approximately 8,100,000 gallons of lubricating oil to the Standard Oil Co. of Indiana. About 99% of the stock of the Crown Oil Co. is owned by the White Oil Corporation.—V. Ill, p. 1759. Inter-company sales not attractive field," very Power" just issued by the firm for distribution to Statement Dated Dec. 15 1920. Notwithstanding that the Preferred dividend has been earned for the full year by a very wide margin, the directors consider it to the ultimate ad¬ vantage of the company to conserve cash resources until normal conditions again prevail In the industrial and financial world. Act, thus says a booklet "Water investors. In an analysis potential maximum horse-power availably less than one-sixth, or 9,823,420, have been actually developed to date. booklet describes The the methods of utilizing water power In hydro¬ development and opportunities for the conservation of the the made possible through it, especially in the country's natural resources, saving of coal and labor. The point is made that the utilization of the approximately 50,000,000 available and undeveloped water horse-power in this per would be equivalent to saving about 275,000,000 tons of coai country annum—half our present consumption—and would release a whole of army men and one-third of the freight cars now used In transporting that amount of coal, "■/< —Lane, Piper & Jaffray, Inc., of that beginning Dec. Minneapolis and St. Paul, announce investment securities 15 it will conduct a general associated with the company: Glenn & following men will be W.#Traer Jr., formerly of A. B. Leach White, Grubbs & Co., and Co.; Norman Nelson, formerly member of —Miller & formerly of A. B. Leach & Co. issued an Interesting list comparative statistical data. of investment suggestions They say: liquidation of the security market, prices, 120 Broadway, Co., members New York Stock Exchange, together with "We believe that the thorough accompanied by drastic declines in continue for offers an opportunity to investors that should not long." —Charles Wesley, formerly Vice-President of Inc., has severed his connections Hollister, White & Co.; with that firm and will continue In the general investment business at the same address, 92 Cedar St., N. Y., Inc. Mr. Wesley will retain the entire former —The organization. Columbia Trust Co. has been appointed transfer agent by the Associated Bankers Corp. of an issue of 50,000 shares of and a like amount of Common, and also has been Preferred stock appointed trustee by the Trepok Realty Co., Inc., of an issue of $600,000 Adjustment Mortgage 6% gold bonds. , —William N. 1 Wyant and Wiley W. Glass announce that they have (Dec. 15) formed a co-partnership to deal in investment Willys-Overland Co.—Preferred Dividend Omitted—Status. omitted the declaration of the regular quarterly dividend of 1%% on the $14,044,800 7% cum. Preferred stock, owing to the uncertainties in connec¬ tion with the automobile trade. —The directors on Dec. 15 Official of the passage under the name of Charles Wesley & Co., 960,731 Sept. 30 1920. Total a on a made is to investors wider opportunities for the investment of funds In of available resources it is shown that of the 59,360,000 have .$1,458,067 &c_ 151,332 Total applications for pemits for water power, that Federal Power Commission, an amount greater than Departments involved. very Int. charge, discount, — Act, projects involving from 2,000,000 to 3,000,000 horse-power have already Announcement is made at the same time that the Oct. 31 1920. July 311920. $632,000 $555,977 Quarters and Nine Quarters ending— Sales.a NOTICES CURRENT —HARRIS,FORBES & CO. ON WATER POWER DEVELOPMENT business, in addition to that of commercial paper and bankers' acceptances. Corp.—Earnings—Important Contract.— Income a special report in which he states purchased tin properties in the Malay States, and properties in the new Mayo district, Yukon Territory, Can. On the Malay tin project, the company has expended to Nov. 1 approxi¬ mately $1,200,000. On the Mayo silver-lead claims, approximately $150,000. Further expenditures on the Malay tin project between now and June 30 will amount to approximately $700,000, and further expenditures on the Mayo silver-lead and other projects between Nov. 1 and Aug. 1 will approximate $800,000, all of which will be met by the present resources of Yukon Gold Co. and the Yukon-Alaska Trust combined.—Y.llO.p. 1543 George F. Piper, White Properties, &c.— President William Loeb Jr. has issued that the company has also silver-lead electric Wayagamack Pulp & Paper Co., Ltd.—Recapitalization. Decrease. 1,413,176 4,355,468 the company's water Co.—Capital Increased.— It is reported that a company with this name has filed a certificate New Jersey to increase its capital from $7,000,000 to $30,000,000. / 1920—11 Mos.—1919. 2,942,292 Albert J. . Washington Gas Light Co.—Note Application.— The company has applied to the Wash. (D. O.) P. U. Commission for 132,591 Young, Smyth, Field & Co., Phila.—Plan Approved.— A dividend of $1 per share has been declared on the stock, payable Jan. 15 Three quarterly dividends of $1.50 per share of $100 p. America, Inc.—Dividend Decreased. Vanadium Corp. of Decrease.1 327,970 2050, 1669. It is stated that on to holders of record Dec. 31. Wateree Electric Copper Mining Co.—Production {in Pounds). 1920—Nov .-1-1919. firm name —S. of .Wyant & Co., P. Julien Ravenel, In charge of the Bond Department of Samuel Goldschmidt, has just returned after being absent for which time he was identified with the —"The securities under the with offices at 108 So. La Salle St., Chicago. History and Business, Capitalization, Record of Mac Andrews & Forbes several years, during Federal Reserve Bank. Earnings and Dividend Co." is described in a circular issued by Stone, Prosser & Doty, 52 William Street, New York. —West & Co., members New York and Philadelphia Stock Exchanges have prepared a special analytical circular on Pennsylvania RR. Co# 2434 THE CHRONICLE textile (fivpimzvcwl ginues. glue Veto York, Friday Night, the country. is quiet for the Retail trade is better of the Christmas too high and the people are economizing. factories early in January. Christmas time, Prices was a year ago. closing down, already are it are Many mills and not to until reopen It is customary to take holidays around but this year the holidays are unusually long. That is one of the significant signs of the times. Wage reductions continue in various branches of business. They most noticeable in the textile business, but they spread to other branches, and it is understood that are have they will shortly reach the iron and steel of favorable the in factors the situation industry. is that One of costs production have been reduced throughout the country. It takes less capital to do business than it did a year ago, or six months ago. In fact, within two months capital requirements have been notably reduced. It costs less for even labor and fibres, The great materials, like cotton, wool, raw well as decline in prices, of tary situation. Probably it undoubtedly was other a strain continue to increase. has eased the course, came too soon, none mone¬ for there the credit resources of on nation like the United States. even a It is significant that failures During the last week they have been past. There has been a complete re¬ the largest for years versal of conditions in this respect. ing the silk and pig iron and fuel, both soft coal and coke. as and after failures For a long period dur¬ far below those of pre¬ But for the past week they have reached the war vious years. ran unpleasantly suggestive total of 414, against 837 last week, 125 for this week last year, 139 in 1918, 200 in 1917, and 285 in 1916. Textile trades in New England contemplate a cut in wages of 22%%, and it is believed that in this reduction has unions trade a in some cases There is talk among section of the country of contesting textile councils in New Hampshire that and cut, wage already been made. two have already given notice that if it is made they will strike. But the time is not propitious for strikes, for trade is dull and unemployment is spreading throughout country. Manufactures throughout the country are dull. are noticably quiet. Collections Iron and slower. are And further decline in the stock welcome, at time one market certainly has been if it has not been of the violent sort that even so conspicuous a feature. The commercial munity is gratified to notice, however, that in financial the for rates world dropped to 6%. the main of At money. as has been passed with time, one a indeed, call com¬ no rise loan in rates Merchants regard the money situation in more favorable, despite the fact that a default $25,000,000 to $30,000,000 in the final payment of some income taxes is said to have taken place here. The trades which were hardest hit, according to these figures, were the silk, textile, garment, grocery and automobile lines. There is talk in Congress of granting 60 days' in the matter of grace to delinquents wool. raw Talk of an turned out to be somewhat larger than The condition of winter wrheat just planted average has for 10 years doing increase in tariff rates and equali¬ zation of exchange rates have had some effect. crop The cost of past. some The wheat was recently. expected. for the week not are was an¬ time since it Rock, Ark., have At Chicago representatives in the steel, packing and other plants, have voted to accept wage reductions of 15% for skilled and 10% for unskilled labor. The American Sugar Co. will reduce of wages bread 10%. labor common bakers reduced Boston and Chicago newspapers and one one and two cents a New York loaf. Some New York maga¬ zine have cut prices. Four Ohio Valley plants of the Wheel¬ ing Steel Corporation have cut wages from 46c. to 38c. per all for hour laborers. One of the largest manufacturing wholesale clothing establishments in Toronto has and sus¬ pended, it is stated, owing to the recent big decline in wool woolen goods. Three Bridgeport plants, employing 5,500 workers, have closed until after Jan. 1, viz.: The Rem¬ and ington Arms-Union Metallic Cartridge Co., the machine sewing manufacturers (until Jan. Singer Co., 15) and the Bassick Co., metal workers. Los Angeles dispatch states that A one of the largest manufacturing establishments in the city, making trousers, overalls and wholesale furnishings, was ousted from the Merchants & Manufacturers Association Dec. 16 for violat¬ ing the avowed open-shop policy of the city. York open-shop clothing fight both and large so a In the New sides claim contracting firm in Philadelphia advertised 25 men, gains. A Dec. 16 for on crowd responded that police had to be summoned to maintain order. Applicants for work were asked to call at 7:30 a.m., but they began to gather at 4 a.m. Prices of fresh eggs, owing to unusually this time of the year, warm dropped 5 to 8 cents a weather for dozen in New Dec. 16, representing a decrease of about York on from prices quoted a week 15 cents Refined sugar is down to ago. 7.90c.; hogs at Buffalo, to $9 75, the lowest since November, 1916. Soft coal fell in Pittsburgh on Dec. 16 from $8 to $5 50 per Twenty-five hundred employees of the American ton. Sugar Refining Co. of House in Brooklyn have been laid off. passed the Immigration The Bill, Representatives ban of one year on the entrance of foreign¬ which places a Unemployment is increasing in Oklahoma, according to the State Commissioner of Labor, and it affects practi¬ industries there. all cally nounced A from dispatch in Chicago is increasing. much under 10,000.000 bushels, and the total thus far is 75,000,000 bush¬ els larger than up to this time last year. It is gratifying to in Co. an¬ prices of its products. Okla., announces that Okla., has been closed. Muskogee, First National Bank of Morris, torium of 60 to 90 days, Boiler Kewanee The of from 10 to 20% cuts Farmers there wanted but it was refused. a the Six mora¬ Unemployment During November there were 159 registered applicants for every 100 places open. A leading thread mill at Warwick, R. I., has announced its first wage cut in Steam The Naumkeag Co., of Salem, Mass., has posted a notice of And the Arizona Cop¬ reductions in all departments. wage per amounting to 32%%. forty years, Cotton Co. has made cut of $1 a day in the wages of the a higher-priced miners, and it, is understood other copper com¬ panies will make similar reductions in existing wage scales. At the auction sale of woolen goods here prices were 601 to 75% lower than the last sales in January. In St. Louis applied for every 45 positions, whereas a year 25 applicants for every 300 places. At Providence, R. I., the Jenckes Spinning Co., said to be the) largest producer of tire fabrics in the world, has suspended work in most de¬ ago there is Here a were only complete somersault. mony Eggs are 15 cents per dozen cheaper Refined sugar is down below 8 cents. And exports workers partments until Jan. 3. Cotton is lower. There is a big export business in wheat, and cash wheat has been at a high premium over futures, owing to a keen demand from The from 6 to 10%. negro kinds of foods coffee is gradually declining. Europe. 300,000 Five mills in Little is close to the been declining. than of 300 persons income tax payments. On the other hand, there was rather more business in founded in 1837. reduced wages closed in that State of late. un¬ was eventful week an and New York, ers. the When men wait for a job from 4 o'clock in the morning, as they have been doing latterly in Philadelphia, it means that the worker is seeking the job nowadays. > steel New England The United Textile Workers of America ting goods plant at Plainville, for the first was over as certain that it is as any means as all usual at the approach as holidays, but it is quite not large by part in 13. declare labor will resist the threatened wage reduction. A textile company at New Britain, Conn., will close its knit¬ Dec. 17 1920. most workers nounced Dec. ~OMMERC™LEPYTOME Wholesale business [VOL. 111. from It is grim testi¬ different shape nothing of two years And so it goes. to the fact that business is in very what it was a to say year ago, ago. In Brazil financial the Department of situation Commerce reports state the with serious failures is growing worse, occurring at Sao Paulo and Pernambuco and minor failures serious failures feared at Rio de Janeiro. Madrid cables that German manufacturers are sending to occurring Spain and such woolen goods at vastly Spanish factories that likely to be adopted for home protection. large of quantities notice, too, that sterling exchange is the highest for three months past. Taking the country as a whole, business is quiet, but with declining costs of production American cheaper prices than those charged by trade is Continent, 18c.; South American, 18Mc.; Brazil in kegs, 19Ha. Futures declined in response to a fall in hog prices, dulness of the cash trade, depression in Wall Street and drawing nearer to a normal basis. A sharp fall in prices would give this movement notable impetus. retail Bread in New York City will be reduced loaf and 2 cents on a cent per 14-oz. prices being respec¬ The National Biscuit Co. has re¬ the 20-oz. tively 10 and 15 cents. duced prices on its loaf, new in some products cases 20%. The Loose-Wiles Biscuit Co. has reduced prices from 2 to 5 cents A big hardware company in Southington, Conn., has laid off a number of hands, owing to business conditions. a pound. The help. Noiseless Typewriter Co. has discharged 25% of its To-morrow woolen mills of the Niantic, Conn., Manu¬ facturing Co. at Flanders, and the Bathgate Mill at Water- ford, Conn., will close for an indefinite period. Shoe fac¬ tory workers at Marlsboro, wage reduction of 10%. Mass., have voted a voluntary Two cotton mills in St. John, N.B., have announced that they will start on a stead of 5% duction of days because about 22%%, four-day week in¬ of lessened trade. A wage re¬ affecting approximately 100,000 measures are LARD lower; prime Western, [email protected].; refined to the throughout the country and finally liquidation. On the declines packers, however, have been buying.^To-day prices advanced but they end lower for the week. DAILY CLOSING PRICES Sat. January delivery—cts_13.92 May delivery 13.97 OF LARD Mem. 13.77 13.60 FUTURES Tues. 13.65 13.70 Wed. 13 §0 13.37 IN CHICAGO. Thurs. 13-17 13.45 Fri. 13 42 13-65 PORK quiet and lower; mess $29@$30; family $40@$45. short clear $33@$38. January closed at $22 80, a rise of 30c. for the week. Beef quiet; mess $10@$20; packet $21 @$23; family $27@$28; extra India mess No. 1 canned roast beef $3 25; No. 2 $8 25. $46@$48; Cut meats dull and lower; pickled hams 10 to 20 lbs. 17@18^0.; pickled bellies 10 to 12 lbs. 24@25e. Butter, creamery extras 55@55%c. Cheese, gathered extras 76c. flats 20@28e. Eggs, fresh Dec. THE 181920.] CHRONICLE COFFEE oil the spot declined; No. 7 Rio 6^@6%c.; .No. 4 Santos 9H@10c.; fair to good Cueuta 11]4@11%g. Futures declined here with falling cost and freight prices at Rio and in sympathy with declines at times in stocks and cotton. Liquidation was occasionally somewhat peremp¬ tory. The buying was mostly by the shorts and trade in¬ terests. Rio has a stock of 535,000 bags against 454,000 a year ago, and Santos 2,996,000 against 4,674,000 at this time in 1919. The quantity in sight for the United States is 1,598,414 against 1,386,043 last year. There is evidently no lack of coffee. And the demand is sluggish. There is some quiet speculative buying on declines, however. To-day prices advanced but they end lower than a week ago. A Coffee Exchange membership was sold at $5,250, a decline of $250. Closing prices were as follows: December.. 6 2206 25|M*y 7.1907.201July 7.5107.52 March. .. .. I 6.82(5 6.851 September...7.7407.75 SUGAR lower; centrifugal 96 degrees test, Cuban and Porto Rican 4.63c. Refined declined; granulated 7.90c. to 8.50c. Futures have declined in eompany with spot raw and refined. Some 250,000 tons remain in Cuba and must come on the market some time. It overshadows the situa¬ only that grinding may be slow to start this year partly owing to recent heavy rains, partial dismantlement of some of the centrals, low prices, &c. The crop is generally estimated at around 3,500,000 tons. Mills of the South Porto Rico Sugar Co., according to advices from San Juan have com¬ menced the 1921 grinding season, being the first on the Island of Porto Rico to begin work. Despatches from Washington state that the Ways and Means Committee of the Housd has appointed Jan. 18 and 19 1921 as dates scheduled to hold hearings in regard to the sugar schedule. Lamborn & Co. have advices from London stating that consumption in tion. It is true that Cuban advices say that there are 6 Cuban Centrals grinding against 32 a year ago and November was 91,000 tons compared during October. The International Institute at Rome, Italy, says that the sugar beet crops of Prussia, Belgium, Spain, Finland, Italy, Netherlands, Sweden, Switzerland, Canada and the United States have Great Britain during with 80,000 tons is 36% more Fabricants de Sucre 58 factories are now working in France, whereas 34 were in operation in 1919. Production in refined to October 31 was 61,683 tons compared with 20,583 in 1919. The estimated production in refined value is 244,260 tons. Production in Germany during Sept. totaled 308,122 tons with consumption of 66,505 tons. Stocks at the end of Sept. were 22,262 tons. Licht's latest estimates of the European beet crops point to a yield of 3,770,000 tons, i. e. in Germany 1,200,000 otns, Czecho Slovakia 725,000, France 300,000 tons. Russia and Ukraine are estimated at 50,000 tons. Today prices declined slightly and end a amounted in 1920 to 22,200,000 tons, which than in 1919. According to the Journal des Beet root is 7.90c. for shade lower for the week. Eastern territory and 7.80c. for Chicago and the West. December.. 4 20">4 30IFebruary ...4.2804.3O|M»y January_..._4.1904.29lMarcb.. 4.3904.40! July ...4.5404.55 4.6704.70 Inquiries of late have been more numerous, but there has been very little actual buying. On the other hand, offerings have been heavier. DecemberJanuary carloads 84@86c.; less than carloads 86@87e.; five barrels or less 93@95c. Ceylon, barrels 13 @13 He.; Cochin llH@12c. Olive $2 75@$2 90. Cod, domestic, 75@76c. Newfoundland 80 @82c. Spirits of turpentine, 78c. Com¬ mon to good strained rosin $8 75. OILS.—Linseed quiet. . PETROLEUM steady; refined in barrels 24.50 @25.50c.; bulk 13.50@ 14.50c.; cases [email protected]. Gasoline steady; steel barrels 33c.; wood barrels 41c.; gas machine 50c. The "Oil City Derrick" report says last week's field reports were fairly favorable, although there were no startling develop¬ ments. Reports from Kansas state that activities in the Mid-Continent have decreased noticeably, and it is expected December operations will show a marked decrease from preceding months. Supplies are plentiful, and producers show no anxiety to resume operations for the present. North Texas produced a few new wells of gusher size. Oklahoma brought in several at about 1,000 barrels each. Extensions and new pools were reported from Texas, Okla¬ homa, North Louisiana and Wyoming. North Louisiana reported a producer in the Woodbine sand, Pine Island dis¬ trict, at a depth of 2,875 feet, flowing at 1,000 barrels. that the O a bell Somerset, and 32 *3 83 $6 10 Indiana 4 25 Princeton.. 4 46 Illinois Pennsylvania. Corning Plymouth deg. above..... 4 50 Kansas Sc 2 60 Wooater 4 05 Oorsiqana. light 3 73 Corslcana, heavy3 63 Electra. South Lima aji.J,,** RUBBER w qiiiet $3 00 3 25 2 76 ...... Henrietta Okla¬ homa Ragland North Lima Strawn 3 77 Thrall 3 77 Healdton 3 48 Moran 3 00 3 50 Caddo. La., light. 3 00 Caddo, crude 1 75 De 3 00 Soto 3 25 2 50 3 40 3 50 and lower; smoked ribbed sheets 16 17c.; first latex crepe 17He. brown crepe, thin, clean, 15c. Para, up-river, 19 Me. Banks are not eager to make loans for the present, and this fact caused much anxiety among holders, whose obligations are nearing maturity. OCEAN FREIGHTS have remained quiet. Grain rates reported steady; coal rates weak. Most of the business coal and lumber, with the demand for coal rapidly dwindling. Large quantities of American coal are, it is said, freely offered to French buyers at $14 per ton cost and freight. Coal carriers at Southern ports can be had, it is intimated, at low rates. Export coal business is - in a chaotic state, partly from British competition, following are .s in grain, flour, 2435 the settlement of the troubles in the Welsh region. Big cancellations have hit American coal trade hard. There was at one time too much speculation. .Charters included coal from Atlantic range to Antwerp or Rotterdam, $5; if French Atlantic port, $5 50 December; 25,000 quarters grain from Atlan¬ Kingdom, Antwerp or Rotterdam, 8s. 6d. Jan. 15-31; steamers 64,000 quarters grain from a Gulf port to Mediterranean, not of west Italy, lis. 6d. Dec. and Jan. loadings. tic range to United two east TOBACCO has remained generally dull. in Buyers these times of flux and declining prices for most commodities hold aloof or buy only when they have to and then in small quantities. They believe prices must eventually give way, they have much of late or note. In general prices are called more or less weak or nominal. Supplies however, of whether the more desirable kinds are declared to be rather small here. Some too, think trade will brighten after the turn of the year. Meanwhile supplies elsewhere are evidently burdensome. Offerings in Kentucky recently were not freely taken; some 55% had to be withdrawn even with the average price at Owpnsboro, Ky., 7 23 per pound There are loud com¬ plaints there over the fact that prices are the lowest in five In fact a despatch from Ownesboro, of Dec. 12 said: years. "The Green River Tobacco Growers' Association was or¬ meeting of about 1,200 farmers of the Green River Tobacco district which includes Daviess, McLean, Hancock, Breekenridge and Ohio Counties, Ky. The Association will endeavor to pool the tobacco crop, and work for higher prices. Under the proposed marketing plan the pooled tobacco would be offered for sale at a certain price. If not bought at this price, it would be stored until ganized here Saturday at there was a better a market. Local interests have offered financial aid to the growers in the move, according to or¬ ganizers of the Association. Meantime managers of the warehouses announced that they will continue to receive and sell tobacco." / COPPER quiet and slightly lower; electrolytic 13H@14o. Sentiment is mixed and there is very little interest manifested by the trade, which is due largely to the recent break in London. Large sellers contend, however, that conditions are sound and emphatically deny having done any business below 14c. They believe that with a stronger tendency in the British market the domestic demand will increase. Tin early in the week declined to 32 He. on the continued weak¬ ness of prices in London. But later it was announced that the Malay Government had fixed the minimum price of Singapore tin at £243, and this lifted the price at New York to 33H@34c. Lead, like other metals, declined in sym¬ Spot New York was quoted at 4%@ pathy with London. 5c. Zinc declined with other metals on the break in London. Trade is very Spot St. Louis was quoted at 5.65o. quiet. PIG IRON has remained dull and more or less depressed; The output in England of iron Some American furnaces have as well as steel is falling. reduced prices, it is said, nearly to the level of re-sale quotations. Some, it is inti¬ mated, have named quotations close to production costs. Production of both iron and steel is falling. New business is exceedingly small. In the Mahoning Valley production said to be on the basis of only about 50% of capacity. is Production is steadily falling, is said that French steel is selling and German in the case at least of billets. It is declared that French billets have sold at £12 10s., whereas British cost of production is at least £18. Wages, it^seems, are to be cut in the Young stown, Ohio, district, possibly 20%. Cutting prices in the Birmingham district elicits no response from buyers. Prices are weak but nobody seems to want to buy. Of course dulness is apt to exist at this time of the year. It is said, too, that while independent corporations have reduced output a big concern has increased its working capacity to 90%. But this is ex¬ ceptional. In average prices it is stated there has been a fall this week from $54 24 to $53 57. New business and STEEL is duller than ever. here and in England. It below the price of British are very small. WOOL has sold rather more specifications freely in this country at lower Last week nearly 4,000,000 lbs., it is asserted, were sold at Boston. The next U. S. Government wool auction will be on Dec. 30, with offerings of 3,400,000 lbs., including 3,000,000 similar to the low wools offered recently and 400,00Q lbs. of three-eighths and high quarter-blood grades, the latter including chiefly second clips and fleece South Amer¬ ican combings and carding wools, which will be used more or less as a test of the market for these better grades. Include^ in the sale will be 330,000 lbs. of pulled, 50,000 lbs. of gray and black domestic, 1,309,000 lbs. of South American comb¬ ing, 1,065,000 lbs. of South American carding and 646,000 lbs. of scoured wools. Samples of these wools will be prices. sl},own at the army base on Dec. 27. Cables from South America on Dec. 13 reported superior second clip wools 1H cents per lb. higher. At London Dec. 13 the auctions of the Government's Colonial wool were resumed, with offerings down to 7,400 bales. But only 1,500 bales were sold. The best Sydney greasv merino realized 28d.; Queensland 27Hd.; West Australi a 23 Hd J and Tasmania 29d. Victorian greasy comeback was 2Id.; crossbred 20d. New Zealand greasy crossbred ranged from 15 to 19 Hd. In London on Dec. 14 offerings were of 8,600 bales and • barely 2,500 bales were sold. But competition was more Prices did not improve, but a rather larger percent¬ active. of the offerings was sold than heretofore. Greasy comb¬ ing merinos sold the most readily. The best Sydney realized 23Hd. Queensland 21d. and Tasmanian 28 Hd. Victorian, age Zealand New and Australian West mainly were [Vol. 111. CHRONICLE THE 2436 good quality this week. But at London the sales will be concluded to-day. River Plate cables report that market firm at advances early in the week. It is intimated that rather large orders for quarter and three-eights combing wools for one of the larger worsted mills outside New England to be of having been cabled to Buenos Ayres during the past week in addition to fair quantities of spot wools. At London the wool sale on the 15th inst. 8,000 bales offered met with little demand, about 75% of the quantity the week ending this evening reach a total1 The exports for greasy crossbred, for which there was no demand, except for the best New Zealand at a range of 14 ^d. to24M<L Boston wired that advices from the auction in Melbourne, Australia, indicated a declining tendency on the 13th inst. and buyers showed less interest. The offerings at Geelong are reported 121,935 bales, of which 40,166 were to Great Britain, to France and 81,769 to other destinations. Below of week and since Aug. 1 1920: the exports for the are Week ending Dec. 17 From Aug. 1 1920 to Dec. 17 1920. 1920. Exported to- Exported to— Exports Great Great from— Other. Houston 76,968 3,300 22,807 Total. 54,161 Britain. France. Galveston- _ Texas City. 3,300 454,969 8,980 2,709 44,111 127,259 .. Other. 195,243 Total. 528,180 1,178,392 6,373 18,062 62,023 233,393 650 Arthur Port France. Britain. 650 San Antonio "¥,244 El Paso...- 177 < PortNogalez Jacksonville have been well maintained on the best wools. Cables from the sale in Brisbane indicate lower prices or about 10% under 800 11,682 84*482 196,909 give The selection was a very indifferent of the French combing type are understood to have cost about 65c. to 67c., clean-landed basis. 950 341,784 3,925 6,957 Mobile The best Sydney greasy. merino sold at 34d., Queensland at 24d., West Australian at 21 lAd., Vic¬ torian and New Zealand, chiefly greasy crossbred, only a few lots sold, the best at 20 lAd. and 20d., respectively. Tasmanian greasy comeback sold at 37 Ad. It is reported that no sales have been scheduled in Australia next month apart from the sales in Tasmania, which are usually of wools very suitable to the United States. At London on Dec. 16 9,892 bales were offered. The trading was quiet and with¬ out feature. There were frequent withdrawals of crossbreds. Cables from Geelong on Dec. 16 showed easier prices; the best combing dropped 5 to 10%, with Americans the largest buyers, the selection being good. At the Brisbane sale prices also fell on that day, with heavy withdrawals. Later cables from the auction at Geelong state that prices there 177 950 195,983 39",880 105",921 15~855 33",214 "17",359 New Orleans 8,244 New York. being withdrawn. Sydney prices. last 701 a 7,427 Brunswick Charleston 701 35*206 77,221 __ 7,427 "2", 800 27",661 1,378 6,126 1,378 400 New York.. 400 •"V,065 2,272 37,736 119 349 Boston Baltimore.. 37,700 10,075 28,119 4,000 4,000 Norfolk 5,399 37,700 2,599 . Wilmington. 1,246 Los 559 10,647 2,697 2,697 Angeles Francis 100 100 "lb",647 Seattle 1,100 1,100 5,877 5,877 Tacoma 1,475 1,475 4,600 4,600 Total 1919. 124.550 33,205 Total 1918. 24,104 # 831,789 329,504 993,305 2,154,598 79,310 237,065 1,323,543 938,296 48,811 116,301 255,890 933.033 2.511,466 536.055 P742,654 81,769 121,935 40,166 _ Total 43,386 218.303 In addition to above exports, our telegrams to-night also us the following amounts of cotton on shipboard, not cleared, at the ports named. We add similar figurea for ' On Shipboard, Not Cleared for— ! Ger¬ Other Coast¬ Britain. France. many. Cont't. wise. Great Leaving Total. Stock. 253,838 71 92,168 66,152 19.200 "Y.000 Dec. 17 at— 1,000 COTTON Galveston Friday Night, Dec. 17 1920. THE MOVEMENT OF THE CROP, as indicated by New our For the telegrams from the South to-night, is given below. this evening the total receipts have reached 189,642 bales, against 210,301 bales last week and 231,762 bales the previous week, making the total receipts since Aug.201920 3,110,707 bales, against 3,392,954 bales for the same period of 1919, showing a decrease since Aug. 20 1920 of 282,047 bales. week ending 44,230 16,444 8,000 Orleans.^ Savannah Tues. Wed. 16,350 25,043 11,915 Total. Fri. s. 11,874 1,226 84.547 "8,317 7,218 11,778 935 588 7,218 63,747 4,826 78 7,316 Galveston 78 "1,206 "2,008 1,433 10,058 12,049 City 1,226 Houston Port Arthur, &c. New Orleans "9,245 9,896 12,368 960 353 684 "MOO "l~,218 Mobile 2,793 150 150 457 285 380 251 147 922 288 209 560 627 1,486 1,929 738 1,393 2,304 2,680 8,482 12,143 1,306 "6", 721 Mobile Norfolk New Jacksonville Savannah Brunswick Charleston 147 Wilmington 711 Norfolk 1,653 1,283 ■ 1,535 York New '""152 Boston """575 6 425 50 Baltimore """"69 21,964 441 61 380 Totals this week. 32,005 28,343 43,552 25,459 38,319 189,642 total The following shows the week's total receipts, the since Aug. last year: 47 1,535 1,277 1,026 1,026 Philadelphia # 47 : N'port News, &c- with 1 1920 and the stocks to-night, compared 18,486 14,708 8,000 19,036 25,593 1,200 Total Total * 11.830 a2,884 500 500 82.595 . 20,677 20,240 1919.- 163,864 77.924 1918.. Estimated, a 2,000 200 3,000 1920. 800 2,000 200 Other ports Total "2",223 3,500 4,000 York 42.146 43,694 51,513 9,616 131,047 33.325 in cotton at times has been 68,035 22,051 62,211 5.071 203,550 1.202.523 6.503 331,270 1,237,601 16,900 170,295 1,221,588 future for higher, with a delivery has been of It is true that Liverpool better demand. been calling for the lower grades there, creased. 4,500 1,700 7,000 402,738 138,832 245,030 9.788 2,484 for Japan. moderate volume at lower prices. The Continent has bought India has and sales have in¬ futures there. Private dispatches have said that the tone in Liverpool was better, that the Pensacola 6,916 9,336 2,000 Charleston Speculation Thu Man. Sat. Receipts at— Texas 5,678 4,024 559 Philadelphia San 41,310 3,287 2,429 better wools The one. Savannah offerings ing" cotton to ter were some small, and that the trade was "call¬ reported yarns quiet was something print cloths new. was On the 16th instant Manches¬ extent. but The word "steady" steady. At the same time a better demand for reported here. Spot markets in the Caro- latterly been Mill stocks of raw cotton in some parts of the country have become re¬ duced after a prolonged period of inactivity in the actual staple. At times, too, the price at Alexandria, Egypt, has advanced quite sharply on the January delivery. Liverpool and Japanese interests have bought here, especially the lat¬ Georgia, linas, firmer. The ter at times Texas and Oklahoma have basis, it was said, was hardening. on a noticable scale. So have trade interests. They have been buying January in some cases and transStock. 1919. 1920. Dec. This 17. Since Aug Week. Galveston Texas City Houston Port Arthur, &c-„ New Orleans Mobile 1 1920. 84,547 1,533,242 13,509 1,226 233,393 7,218 14,940 63,747 678,751 4,826 42,923 This Week. Since Aug 1 1919. 74,489 1,112,109 152,474 20,099 23,319 ""73 45,846 3,648 Pensacola 78 "l",0i3 "696 10,058 336,067 8,624 37,874 46,834 118,737 55,220 2,000 8,241 3,975 11,552 969 79 Jacksonville Savannah 150 Brunswick Charleston 2,304 2,680 8,482 Wilmington Norfolk 47 N'port News, &c_ New York 1,535 1,277 1,026 Boston Baltimore- - 441 Philadelphia 19,463 514,717 164,918 11,170 7,961 754,672 92,800 167,911 88,342 193.114 1,556 11,765 time 1920. 1919. 346,006 2,575 322,961 90,038 468",890 465*303 19,982 21,618 " "2". 137 7*092 158,032 2,249 40,711 72,535 355,905 19,500 64,212 45,883 95,429 246.030 6,434 291 23,751 62", 129 16.070 18,138 3,389 245 9,820 12,016 1,070 56,142 10,701 3,369 3,877 5,133 11,427 837 6.154 189,642 3,110,907 228,361 13,392.954 1,406,073 1,568,871 Totals In order that comparison may we be made with other years, give below the totals at leading ports for six seasons: Receipts at— 1920. 1919. 1917. 1918. Galveston 84,547 74,489 TexasCity,&c. 8,444 63.747 20,172 51,857 5,067 49,001 7,962 34,255 30.221 "6", 889 5.761 595 10.222 2.680 Norfolk 8,482 11,552 3,351 10.435 47 79 78 Brunswick Charleston N'port N., &c. 60,237 12,600 31,090 3,707 13,758 487 44,310 902 1,766 1,000 3.500 2,741 1,382 11,115 1915. 90,100 9,825 53,777 3,344 19,631 3,000 5,396 2,509 15,621 287 4,357 All others Total this wk_ Since Aug. 4,826 10.058 150 2,304 1916. 214 Wilmington.. 45,846 3,648 55,220 2,000 8,241 3,975 OrleansMobile Savannah New 3,139 2,462 11.521 "8",513 8,488 189,642 228,361 171,357 122,999 148,643 211,978 1_ 3,110.907 3,392,954 2,529,152 3,302,575 4,475,451 3,857,774 January at one There is said to be quite a large short interest in January, largely for Liverpool account, though the short interest is not by any means limited to that market. It will be recalled that January showed very striking strength a year ago. In fact, the strenuous experience of the short interest in January and March, May and July is still fresh in the remembrance of the trade, as outstanding features of the season of 191920. As the case now stands, there is said to be under 8,000 bales of certificated cotton here. Quite a little of the cotton sent to New York recently, it appears, has been rejected. And concededly the present cerificated stock is a slender basis for a big short interest. And the evidence seems to multiply that the South is determined to cut the next acre¬ age very sharply.' The decrease talked of is 33 1/3%. Some would not be surprised if such a decrease should be fering their hedges to March and Receipts to increased its May. premium over other months. approximated unless there is a very sharp improvement in cost of production, in one way or another, should be considerably reduced. The idea is that cotton the price or the farmers, like farmers in every other part of the country, spent money with a free hand in the flush times, as did the working population all over the country, and that they are now hard hit by the big drop in prices. Therefore it is believed to be easily possible that there may be a big reduc¬ tion in acreage, unless, as already intimated, something in¬ change his mind. Meanwhile tervenes to make the farmer ^ getting into better shape. The price of cotton has fallen since July nearly 65%, wages are to be cut 22^%, and soft coal has recently been declining. In a word, the the mills overhead are charges of the duced and may be mills have been considerably re¬ another at no cut further in one way or , Dec. very distant have been day. All of which means market for He has been out of the unavoidable inference from this, according to very many, is that before long the mills have got to buy to increase their But to on while a sentiment in the preponderance quarters has been some few a are Range Range more hopeful, Closing Range Range Range Range until Jan. 3 1921, or Jan. 5. Things are so bad that in in 40 years have cut wages, even reducing them 33%%. No one pretends that there is any real activity, either in the spot markets or at the South. Many business men found it impossible to pay their final installment of the income The trades that were hardest hit were tax. silks, textiles, There has been a owing to the bad times, 30 days be allowed to delinquents. Meanwhile thousands face the Government penalty, regretting that they did not pay last March when money was relatively plentiful. All this is a sign of the times. It certainly does not indicate a gratifying state of business, to put it mildly. But there are those who think that the turn in the long lane has been reached. They look for no spectacular rise, but they do look for a gradual improvement in the price, based on the economic law that the price of a commodity cannot remain garment, "grocery and automobile lines. below the cost of production. And the last crop did cost the South, it is estimated, something like 30 cents per pound. Of course the cost varied according to the section of the belt, but the rough average it is believed of 30 cents is sufficiently accurate for practical purposes in Range 3.35 on 2.80 on Middling ftir Strict good middling——■ Good middling ....2.20 1.13 Strict low middling.. 2.30 Low middling —————4.68 ♦Strict good ordinary———6.43 ♦Good ordinary. ......8.00 Strict good mid, "yellow" tinged.0.39 Good middling "yellow" tinged..1.03 Strict, middling "yellow" tinged..2.08 Strict middling.— — .. — on on off off off off otf off off ♦Strict low mid. "yellow" tinged.5.53 ♦Low middling 15.10 — 15.50 — 15.50 — 15.77 15.62 15.40 — — 15.40-.70 15.00i.ll 15.40-.44 15.70 15.25 16.05 — 15.45 — 15.55 — 15.64 — — 15.45 14.95-.00 — 14.95-.70 15.45-.75 15.08 i.20 15.98-.20 15.28-.95 15.08-.65 15.48-.85 15.5516.10 15.30-.33 15.60 — 15.58 16.10 15.30 — 15.60 — 15.58 15.43 _. — 15.35 — 15.43 — 15.70 — — 15.45-.47 15.64- ... .. 15.64 — 15.50 — 15.80 — 15.76 16.10 — 15.67 — — 15.82 — 15.60 — 15.35-.80 Range... 16.10-.20 15.35-.93 15.10-.60 15.50-.80 15.60-.79 15.50-.72 15.10i.20 Closing 16.05-. 10 15.30 _. I 16c. — 15.60 — 15.57 — 15.72 — 15.50 — /15c. THE VISIBLE SUPPLY OF COTTON to-night, as made by cable and telegraph, is as follows. Foreign stocks, as as the afloat, are this week's returns, and consequently up well all brought down to Thursday evening. the complete figures for to-night (Friday), we add the item of exports from the United States, including in it the exports of Friday only. foreign figures But are the make to total 1918. 1917. 937,000 829,000 305,000 430,000 3,000 93,000 11,000 153,000 16,000 75,000 21,000 26,000 993,000 396,000 477,000 180,000 7,000 38,000 31,000 67,000 153,000 3,000 76,000 45,000 434,000 256.000 101,000 250,000 1,467,000 1,249,000 497,000 14,000 355,000 727,000 1920. December 17— Stock afc Liverpool .bales.. Stock at London Stock at Manchester Stock at Ghent. 1,033,000 14.000 Stock at Bremen Stock at Havre 170,000 17,000 1919. 112,000 Total Great Britain Stock at Rotterdam, &c Stock at Barcelona.. Stock at Genoa • 1,000 64,000 30,000 21,000 12,000 Stock at Trieste Total Continental stocks...... Total European stocks India cotton afloat for Europe 43,006 84,000 37,000 , 691,857 256,000 Europe 651,933 55,000 48,000 96,000 Egypt, Brazil, &c., afloat for Eur. 63,000 239,000 320,000 361,000 Stock in Alexandria, Egypt 183,000 521,000 *445,000 *570,000 Stock in Bombay, India.i....... 886,000 Stock in U. S. ports 1,406,073 1,568,871 1,391,883 1,282,097 Stock in U. S. interior towns 1,640,145 1,347,767 1,390,823 1,259,429 5,949 4,570 15,995 U. S. exports to-day. — 16,831 Amer. cotton afloat for ..6,356,982 5,772.490 4,633,655 4.427.096 Total visible supply.. Of the above, totals of American and other descriptions American— U. S. • off 81,000 364,000 651,933 to-day 16,831 ........— 199,000 691,859 42,000 *85,000 355,000 256,000 1.282.097 15,995 4,570 5,949 201,0r0 128,000 145,000 3,000 12,000 70,000 43,000 11,000 71,000 57,000 84,000 16,000 33,000 *16,000 14,000 21,000 6,000 *34,000 37,000 Continental stock.. India afloat for Europe 63,000 Total East India, &c Total American — 55,000 48,0^0 183,000 886,000 Egypt*, Brazil, &c., afloat Stock in Alexandria, Egypt Stock in Bombay, India quotation for middling upland cotton in the York market each day for the past week has been: I 285,000 20,000 *216,000 375,000 Manchester stock future contracts. follows as 177,000 4,721,982 4,533,490 3,447,655 3,323,096 Total American East Indian, Brazil, &c.— London stock "yellow" stained.3.25 off ♦Strict mid. "yellow" stained...4.40 off ♦Middling "yellow" stained 5.80 off ♦Good middling "blue" stained..4.05 off ♦Strict middling "blue" stained..5.35 off ♦Middling "blue" stained6.60 off ♦These ten grades are not deliverable 628,000 82,000 ..1,610,145 1,347,767 1,390,823 1,259,429 Liverpool stock "yellow" tinged..7.80 off 562,000 1,406,073 1,568,871 1,391,883 port stocks U. S. interior stocks U. S. exports are . Liverpool stock...... bales.. Manchester stock.............. Continental stock American afloat for Europe Good middling upon — — 15.90-.11 15.15-.85 15.00-.58 15.37-;.80 15.4916.01-.04 15.22-.23 15.57-.58 15.51-.52 15.60- .. Closing.. 3.58 of ♦Middling "yellow" tinged — October— :'-V Dec. .23: 15.90 Range... following averages of the differences between grades, as figures from the Dec. 16 quotations of the ten markets, designated by the Secretary of Agriculture, are the differences from middling established for deliveries in the New York on 15.40 15.37-.38 ... dosing The market 15.65 15.40 September— since last Friday. of 25 points decline 15.40 15.35-.65 14.82/.95 ... Closing Middling on the spot closed at 16c., a lower for the week. — 15.77 ... Range To-day prices declined and ended point. discussing this 15.00 August— suggestion in Congress that, permanently '5.40 — 15.80-.85 15.00-.04 15.40-.45 15.40-.44 15.61- _. Closing., 1918, Rhode Island mills for the first time thread mills, 15.45 July— 11,302,375 in 1917. The mills are working only two or three days a week. now 15.33 15.74-.95 15.00-.69 14.82-.45 15.15-.70 15.40- _. ... Closing and the — June— posed to anything of the sort. The Government crop esti¬ the 13th instant and proved to be 12,- Some are closing even 15.83 .. Closing May— mate was issued on It is difficult to sell their product. _ Closing for SQme time to 987,000 bales, against 11,420,763 last year, 12,048,532 in 15.30 April— Board serve — March— Moreover, it is believed that both the Federal Re¬ and the Bank of England are distinctly op¬ kind. Week. Dec. 17. 15.62-.88 14.95-.65 14.77-.38 15.10-.62 15.38-.83 15.43-.80 14.77/.88 15.82-.84 14.95-.02 J5.37-.38 15.37-.38 15.72-.75 15.43-.48 ... .. of opinion is still either bearish or more or Friday, Dec. 16, Range... opinion would not tolerate anything of the Public 14.95 15.65 .. Closing February— looking askance at the short side, speculation in commodities just now, Dec. 15. 15.40-.65 14.S0-.55 14.66-.30 15.05-.55 15.23-.55 15.35-60 14.66-.65 ... Closing at this time. come. Dec. 14. January— skeptical as to the possibility of a permanent rise Certainly nobody looks for old-fashioned bull less Tuesday, Wed'day, Thursd'y, Dec. 13. December— things moving at a swifter pace towards a set Monday, Dec. 11. country the throughout jog not only to retail but to wholesale normal, healthy and prosperous times. the other hand there is no disguising the fact that and that not or textiles, including sharply, it will give return And if retailers cut the price of cotton. raw merchandise, trade and Saturday, Owing to the curtailment of output, November receipts of raw cotton in New England were the smallest for many years past. The purchases of highest, lowest and closing prices at week have been as follows: New York for the past good while, and in many cases his stock of a material must be considerably reduced. raw FUTURES.—The that mill expenses sharply curtailed, and that the spinner is in a better position to buy raw cotton. 3437 CHRONICLE THE 181920.] 239,000 521,000 361,000 *570,000 96,000 320,000 *445,000 1,635,000 1,239,000 1,186,000 1,104,000 4,721,982 4,533,490 3,447,655 3,323,096 The official New to Dec. Dec. 11 Sat. uplands Middling Mon. Tues. : NEW YORK — 16.25 15.50 15.80 15.80 16.00 Liverpool.. York Egypt, good sake!, Liverpool Peruvian, rough good, LiverpoolBroach, fine, Liverpool—— Tinnevelly, good, Liverpool Middling uplands. New 16.00 QUOTATIONS FOR 32 YEARS. * quotations for middling upland at New York on Dec. 17 for each of the past 32 years have been as follows: The 1020 16.00 39.25 29.75 30.30 18.35 11.95 7.30 12.90 -c. 1919 1918 1917 1916. 1915 1914 1913 1912.C 1911 1910 1909 1908 1907. 1906. 1905 13.10 9.45 15.15 15.10 9.10 11.90 10.55 12.20 8.05 12.70 1902....... 8.70 1901 8.50 1904.c_ — 1903 1896.C 8.56 — of 1891 7.94 1898. 5.81 1890 9.38 1897 5.88 1889 10.25 each day during the indicated in the following statement. For the convenience of the reader we also add columns which The total sales of cotton on the spot over ' on glance how the market for spot and futures closed d^-ys. a same 39.50d. 37.00d. 10-15d. ll.OOd. 23.85d. 24.10d. 18.79d. 18.04d. bales.) 1917. QUOTATIONS FOR MIDDLING COTTON AT OTHER MARKETS.—Below are the closing quotations of middling cotton at Southern and other principal cotton markets for each day of the week: ' ■ . week at New York are show at 17.00d. 22.3ld. 31.10c. 33.15d. 32.00d. 23.15d. 21.53d. 1920 show an increase over last week gain of 584,492 bales over 1919, an excess of 144,874 8.00 10.00 MARKET AND SALES AT NEW YORK. 20.40d. 31.00c. bales, a 1,723,327 bales over 1918 and a gain of 1,929,886 bales 5.75 1892 ... 30.79d. The above figures for 1893 1894 26.12d. 39.25c. 51.00d. 10.58d. 16.00c. Estimated. 10.00 7.69 1900 1899 27.00d. Continental imports for past week have been 133,000 7.19 1895 6,356,982 5,772,490 4,633.655 4,427.096 Total visible supply Middling uplands, Fri. Wed. Thurs. 17— Closing Quotations for Middling Cotton on— Week ending Dec. 17. Saturday. Monday. Galveston 15.75 14.75 14.75 15.78 Tuesday. Wed'day. Thursd'y, .15.25 15.25 15.78 15.78 15.25 14.75 14.75 Friday. 15.25 15.25 14.'/ 5 Market Closed. 14.75 14.75 14.75 15.75 15.75 15.75 Saturday _ — Quiet, unchanged. Quiet. 75 pts. dec. Quiet, 30 pts. adv. Monday Tuesday Wednesday. Quiet, unchanged. Quiet, 20 pts. adv. Thursday Quiet, unchanged. Friday — Total Market Closed. 15.78 15.00 14.50 14.50 14.50 15.00 15,00 15.50 15.50 IS.7 5 15.50 16.05 16.05 16.25 15.13 15.00 16.25 _ Savannah Spot. Contr't.' Total. Firm Easy Steady Steady Steady Easy Charleston New Orleans. Mobile SALES. Futures 14.75 14.75 15.78 15.78 Norfolk. Spot Baltimore— 200 200 "566 "500 500 500 15.00 15.00 15.00 .... 14.10 13.30, .... 14.75 14.25 15.50 15.00 Houston 1,200 167.50 Dallas Rock Fort Worth.— Little 1,200 — Philadelphia Augusta Memphis 15.38 13.50 14/75 15.00 15.00 13.70 14.25 15.00 13.75 15.78 15.78 15.00 15.00 13.80 14.25 15.00 13.75 15.00 15.75 15.00 15.00 14.10 13.90 14.50 14.25 15.00 15.00 14.10 13.85 INTERIOR TOWNS the movement.—that is, AT THE 1, the shipments for the same items for the corresponding period of the previous year—is set out in the receipts for the week since Aug. the week and the stocks to-night, and detail below: The following statement we have also received by tele¬ graph, showing the height of the rivers at the points named at 8 a. m. of the dates given: Nashville Dec. 17. Season. Week. Stocks Dec. Week. Shreveport. Vicksburg Ala., Eufaula.. 311 7,130 Montgomery Selma 619 43,292 292 f',234 107 3,620 32,100 1,974 57,529 2,388 22,120 33.168 2,298 345 Ark., Helena .. Little Rock.. 1,848 ?5,086 925 15,644 1,304 24,339 734 7,460 9,151 9,181 4,535 60,485 9,680 122,734 5,761 51.974 Pine Bluff— 9.399 108,936 100,429 9,841 65,980 Ga., Albany... 130 9,829 17 6,476 64,581 5,300 98,208 4,800 8,046 14,368 152,039 12,719 369,854 15,354 207,030 82 27,469 478 ...... 16,169 82,582 21.475 3,867 68,843 10,08f 224,159 3,919 31,391 5,463 154,144 Columbus... 1,070 Macon 1,204 15,171 26,352 19,563 60,135 6,465 78,182 5.384 Athens Atlanta — Augusta .... 1,346 2.710 Itome....... ■ - - - 22,330 . 100 — - 9,064 i* 19,000 3,154 45,539 39,863 - 100 122 16,924 525 31,259 1.139 701 18,608 8,260 58,398 4.328 7,048 1,200 157,125 8.487 1,150 3,660 39,461 55,405 1.200 13,317 4,518 3,500 92,164 927 27,500 50,254 17,137 54.560 Greenwood.. 2,334 300 86,438 Meridian 1,041 71,344 16,824 85,928 64,259 2,167 1,200 3,458 2,900 438 12,160 800 26,691 800 13,500 800 16,038 400 7,534 648 23,658 181 952 8,462 20,220 203,713 200 12,496 697 13,626 49 757 19,618 15,743 4,668 1,036 30,149 266 1,000 121 273 52 29,855 334,722 26,270 7,975 12,054 9,697 14,441 7,491 11,607 100 224 La., Shreveport Mlsfl.,Columbufl Clarksdsle Natchez 518 4,078 .. .... Vicksburg— 1,142 ------ 3,143 Yazoo City.. 1,161 Mo., St. Louis. N.C.,Gr'nsboro 25,626 Raleigh..... 182 5,441 2,443 Okla., Altus 3,463 27,126 1,981 15,984 Chickasha 2,188 24,169 1,669 10,756 700 16,300 500 7,434 2,476 30,542 1,766 2,247 1,090 8,397 12,254 3,812 300 10,722 572 21,203 369,870 38,846 1,126 Hugo Oklahoma Greenwood.. 607 25,059 11,228 Tenn., Memphis 2?,219 25,168 385,950 S. C., Greenville Nashville _ ... 415 . 858 - - - 13,145 507.423 - - - - - 4,397 - - 4,63 J 247 - 802 31.178 572 - - - 2,521 32,687 43,755 3,090 18.663 Honey Grove 1,200 18,800 1,000 9,990 1,569 22,016 859 3.408 San 651 31,824 317 3,407 3,615 1,200 6,326 53,763 5,015 20,451 2,000 Antonio Fort Worth *_. 69,273 235,181 83,318 29,469 1,200 2,320 25,700 2,500 24.500 3,324 11,107 * Georgia Florida Alabama Mississippi.. Louisiana... Cincinnati. creased during the week 53,422 bales and are to-night 292,378 than at the same time last year. The receipts at towns have been 3,920 bales less than the same week bales all more 1,530,000 1,400,000 18,000 660,000 885,000 380,000 (Census). Steady Steady 4,200,000 1,160,000 310,000 85,000 1,300,000 *150,000 110,000 15,000 U.S.....6,213,262,000 12,987,000 11,420,763 California Arizona All other 35.7 15.3 17.0 358 15.0 153 14.2 924.826 1,028,580 492,030 42.0 34.8 37.5 350 13.2 13.3 35.0 13.0 3,473,446 985,459 327,916 63,089 852,259 49,437 1,016,129 56,107 59,849 4,947 40,690,000 622,180,000 *71,580,000 52,635,000 7,172,000 35.0 352 14.5 47,562 310,044 64,031 Oklahoma... 15 0 145 2,090,793 884,473 1919. 1920. 22,364 760,096 1,281,270 960,886 297,681 3,098,967 148,335,000 Missouri The above totals show that the interior market have in¬ (Census). 22,523 830,293 1,426,146 1,659,529 15.922 713,236 2,012,220,000 555,176,000 Arkansas Tennessee Last year's figures are fcr Steady Steady 5-yr. Avge. Price per lb. 1914-18. Dec. 1. 1919. 9,069,000 400,764,000 730,728,000 669,340,000 8,687,000 315,414,000 423,384,000 181,678,000 Texas «6 l«40145 227.4083.896.949 216.9521S477R7 Total, 41 towns 223f4S8 3.6S4.027 170, 17. — Lbs. Gross Weight 1920. 19,000 840.000 1920. So. Carolina- 16,766 Steady Steady Steady Bales of 500 No. Carolina 73,218 1,085,948 Steady Lint. Virginia. 2,000 DAY. Steady Pounds 7,598 28,029 HOLI¬ — The Crop Reporting Board of the Bureau of Crop Estimates of the United States Department of Agriculture estimates, from the reports of the corre¬ spondents and agents of the Bureau, that the total production of cotton in the United States for the season 1920-21 will amount to 6,213,262,000 lbs. (not including linters), equivalent to 12,987,000 bales of 500 lbs. gross weight (478.3 lbs. lint and 21.7 lbs. bagging and ties estimated per 500 lbs. gross weight bale). The estimated production for 1920, with compari¬ sons, by States, follows: 2,160 20,800 14.55 14.30-40 14.60-.61 14.84-.87 14.58-.61 14.70-.81 15.04-.07 14.80 — 14.96-.98 15.16-.18 14.92-.93 15-02-.08 15.21 — 14.96-.00 14.85 — 15.04-.05 14.85 — 14.23-.32 14.45-.48 — Friday, 16. Dec. AGRICULTURAL DEPARTMENT'S COTTON CROP issued by the Agri¬ cultural Department on Dec. 13, is as follows: 70 70 908 14.20 — 14.69-.70 14.77-.80 15.00 15. Dec. ESTIMATE.—The report on cotton, 1,296 4,175 12,900 14.10 Steady Spot Options...... 5,545 75 63,821 328,852 4,813 21,731 .... State— 9,137 82,440 1,580,406 55,419 3,403 October 17.8 41.9 Tone— 3,857 27,004 800 Houston — 1,338 1,006 1,000 Paris May July 552 - Dallas.. .. — March 33.8 12.5 14.4 14. Dec. 13. Dec. 11. Dec. 14.76-.78 14.96-.98 15.16-.20 15.35-.3 7 15.45-.47 15.36 — 1C.110 700 Olarksville January 35,362 269,073 653 - - 357 19,424 64,748 ■ - - 20,262 - 2,773 86,952 Brenbam 1,354 28,663 14,035 ---- 1,273 ------ 36,500 ------ - 2,529 ~2, 667 170 Tex., Abilene.. 1,000 6,588 48,317 December— 31.3 . . 15.4 Tuesday, Wed'day, Thursd'y, Saturday, Monday, Dec. 12.0 week have been as follows: the past markets for 1919. Feet. 13.4 the New Orleans cotton quotations for leading contracts in 4,634 Dec. 19 y:v CONTRACT MARKET.—The closing NEW ORLEANS 19. 63 53 .. Receipts. Stocks Week. Season. Week. Ship¬ ments. Ship¬ ments. Receipts. Towns. 19 1919. 17 1920. Feet. 4.8 of gauge. of gauge. of gauge. of gauge. Above zer oof gauge. Above zero ....Above zero Above zero Above zero Memphis Movement to Dec. 17 1920. Dec. * New Orleans Movement to Dec. [VOL. 111. CHRONICLE THE 2438 33.5 36.4 13.5 340 10.5 300 300 352 43.0 51.0 14.0 35 6 24,792 12,423,917 last year. * MOVEMENT OVERLAND SINCE AUG. 1.—We overland movement for THE FOR WEEK AND give below a statement showing the the week and since Aug. 1, as made from telegraphic reports Friday night. up the week and since The results for Aug. 1 in the last two years are as follows: - -1919- 1920 Since Since December 17— Week. Shipped— Aug. Week. Aug. 1. 028,663 0341,541 17,489 -16,343 155 8,254 2,896 41,843 1. Via Louisville 847 2.,842 6200,788 93,321 6,453 23,414 Via Virginia points..'.. Via other routes, &c 2,816 8,947 43,467 90,829 2,315 15,445 71,996 148,675 46,083 458,272 66,963 828,652 Y., Boston, &c___ 4,279 6,501 44,031 7,761 a71,295 2,766 7,231 11,574 123,087 12,440 222, Q65 Leaving total net overland* ..34,509 335,185 54,523 * cli " --. . Including movement by rail to Canada, a Revised. 6 21,404 bales added as revision since Aug. 1. 606,587 ...25,168 Via St. Louis 5,463 Via Mounds, &c Via Rock Island Total gross overland Included in "All other " The total production in 1919 was 11,420,763 bales (500 lbs. gross), in 1918, 12,040,532 bales; in 1917, 11,302,375 bales; in 1916, 11,449,930 oales; jn 1915, 11,191,820 bales; in 1914, 16,134,930 bales, and in 1913, 14,156,486 Including some in Mexico, grown a bales. The average weight per running bale is estimated at 506.9 lbs. gross, compared with 504.2 lbs. in 1919 (as reported by the Bureau of the Census), 505.6 lbs. in 1918, 502.4 lbs. in 1917 and 506.2 lbs., the average for the preceding five years. Reports of the Bureau of Crop Estimates do not include linters, which are a product obtained at mills from the seed. The production of linters is about 8 3% as much as the lint production, average 1914-18. COTTON CONSUMPTION AND OVERLAND MOVE¬ DEC. MENT TO crop 1.—Below we present a synopsis of the movement for the month of November and the four months ended Nov. 30 for three years: Deduct Shipments Overland to N. 794 Between interior towns Inland, &c., from South Total to be deducted 88,428' 34,850 98,787 2,443 The foregoing shows the week's net overland movement bales for the week last year, and that for the season to date the aggregate net overland exhibits a decrease from a year ago of 271,402 bales. has been 34,509 bales, against 54,523 -1919- -1920In Since Since Sight and Spinners' Takings. Week. Total marketed... Interior stocks in excess Came into sight during week Total in sight Dec. 17 _ _ Aug. 1. 335,185 50,000 1,302,000 228,361 54,523 73,000 3,392,954 606,587 1,375,000 274,151 53,422 Southern consumption to Dec. 17a Week. 3,110,907 34,509 Net overland to Dec. 17 Aug. 1. 189,642 Receipts at ports to Dec. 17 4,748,092 780,204 355,884 10,456 .327,573 5,920,261 5,528,296 Week— Bales. 326,328 286,627 292,182 1916—Dec. 22 1,270,452 1918—Dec. 1917—Dec. 21 1916—Dec. 22 TELEGRAPH.—Reports to us by telegraph this evening from the South indicate that while rain has fallen in most localities during the week, the ^precipitation has been light as a rule. Thermometer Rain. Rainfall, Abilene, Texas dry 1 day 0.04 in. dry Dallas Corpus Christi 1 day 0.06 in. Palestine 1 day 0.08 in. 0.01 in. dry 0.20 in. San Del 1 day Antonio Rio Galveston ... 2 day New Orleans, La 3 days 4.72 in. Shreveport Vicksburg Selma, Ala Mobile, Ala Savannah, Ga Charlotte, N. C_ 1 day 0.06 in. 3 days 3 days 3.50 in. 3.79 in. 2 days 2 days 0.27 in. 0.47 in. high high high high high high high 76 74 low 30 mean 53 low 38 mean 56 76 low 36 mean 56 82 62 low 42 mean 78 low 36 mean 56 84 low 34 mean 59 __ low 28 high 70 high high 71 __ high high high high high 71 66 69 71 64 on Nov. 30 Northern spinners' takings to Dec. 1 Southern consumption to Dec. 1 Overland to Canada for 4 months mean __ low 40 mean 55 low mean 58 low 38 mean mean 55 low 30 mean 48 2,086,801 353,971 1,349,374 1,423,057 785,759 1,411,000 47,903 73,111 1,395",253 1,970,803 4,706,930 4,864,565 4,711,077 7,352,987 6,891,557 12,217,552 11,602,634 1,741",5l0 balance of season Average gross weight of bales Average net weight of bales 603.323 519.50 494.50 - 513.32 488.32 506.05 481.05 WORLD'S SUPPLY AND TAKINGS OF COTTON.— comprehensive statement indicates glance the world's supply of cotton for the week and since Aug. 1 for the last two seasons, from all sources from which statistics are obtainable; also the takings, or amounts at a of sight, for the like Cotton Week period. Season. Week. Visible supply Dec. 10 Visible supply Aug. 1 American in sight to Dec. 17 Bombay receipts to Dec. 16 Other India 1919. 1920. Takings. and ship'ts to Dec. 16__ Alexandria receipts to Dec. 15-Other supply to Dec. 15* Season. Week. 6,212,108 4",792",018 4,956",257 327,573 &40,000 62,000 640,000 65,000 Season. 5,705,526 5,528,296 351,000 105,000 292,000 96,000 366", 340 72,000 11,000 38,000 3,000 5,920,261 613,000 135,000 489.000 83,000 6,626,681 11,328,553 6,195,866 12,032,279 Total supply Deduct— 6,356,982 Visible supply Dec. 17 Total takings to Dec. 17_a Of which American Of which other 269,699 179,699 90,000 6,356,982 5,772,490 5,772,490 423,376 363,376 6,359,789 4,586,789 1,673,000 4,971,571 3,791,571 1,180,000 60,000 55 low 38 307,790 713,628 274,930 573,276 (in¬ Amount of crop in sight Nov. 30 Came in sight Total crop 1918. 359,158 656,822 240,084 471,575 1,227,990 2,733,080 985,706 2,054,747 1,505,139 966,303 1,169,000 cluded in net overland) Burnt North and South in 4 months Came in sight during November Bales. 5,514,220 6,735,900 8,181,373 20.. WEATHER REPORTS BY Brownsville Exports in November Exports in 4 months gone out years: Since Aug. 1— ... The following brief but 366,340 sight in previous 1918—Dec. 20 1917—Dec. 21 Net overland for 4 months.. Port receipts in November Port receipts for 4 months Port stocks 1919. 177,902 363,929 136,993 260,510 1,059,512 2,631,420 719,601 1,731,805 1,374,227 560,973 1,165,000 51,168 Gross overland for 4 months Net overland for November 5,374,541 545,720 North, spinn's'takings to Dec. 17. 33,647 678,404 92,578 a These figures are consumption; takings not available. Movement into 1920. bales. Gross overland for November low 44 mean low 39 mean 55 low 33 mean 48 56 estimated consumption by Southern mills, 1,302,000 bales in 1920 and 1,375,000 bales in 1919—takings not being available—and the aggregate amounts taken by Northern and foreign spinners, 3,669,571 bales in 1920 and 4,884,789 bales in 1919, of which 2,489,571 bales and 3,211,789 bales American, b Estimated. a This embraces the total Dec. 18 BO MBAY the MOVEMENT.—The receipts of Bombay for the week ending Nov. 25 and for from Aug. 1 for three years have been as follows: season at 1918. 1919. 1920. Week. Since Since Since at— Week. Aug. 1. Week. Aug. 1, New as York, as furnished by Lambert & Burrows, Inc., follows, quotations being in cents per pound: Liverpool, ,[email protected]. Manchester, [email protected]. Antwerp, 85c. Ghent, via Antwerp, 85c. Nop. 25. Receipts COTTON FREIGHTS.—Current rates for cotton from COTTON India cotton Havre, Aug. 1. 37 000 64,00( 299.OCX) 415.00C For the Week. 356.000 41.000 Since August Great Conti¬ JapanA Britain. nent. China. Great Britain. Total. Conti¬ nent. & Japan Trieste, 1.50c. asked. Flume, 1.50c. asked. Bremen, Total. China. Reval. Christlania, 1.50c. asked. ■ _ , Nov. 26. , Sales, 33,000 33,000 13,000 183,000 93,000 289.000 16~000 56,000 74,000 17,000 144,000 431,000 592,000 54,000 54,000 108,000 1,000 2,000 3,000 6.000 54,000 38,000 6.00C 5,000 14,000 12,000 42,000 53,000 98,000 107,000 1,000 35,000 36,000 19,000 237,000 131,000 387,000 22.000 61,000 88,000 29,000 186,000 484,000 699,000 54,000 "i'ooo 1919. 54,000 108,000 1918 •Other India* 1920 * "3~,6oo 1919 1918— ^fl¬ " 5",000 ung— 1918— No Libau. Riga. 18,000 American 14.000 — Actual export Forwarded Total 5,000 53,000 874,000 507,000 96,000 87,000 263,000 200,000 stock Of which American Total imports for the week Of which American Amount afloat Of which American Dec. 3. Dec. 10. 23.000 15,000 5.000 53,000 888,000 516,000 81,000 62,000 293,000 244,000 Dec. 17. 16,000 14,000 7,000 53,000 904,000 533,000 78,000 59,000 307,000 240,000 17,000 11.000 8,000 47,000 937,000 562,000 87,000 64,000 The tone of the Total all— * Danzig. . Sales of the we^k Bombay— 1920 1.50c. Hamburg. Shanghai, 1.25c. Bombay, 2.25c. asked. 1.25c. 1.50c. asked. Gothenburg, Lisbon, 1.50c. asked. Oporto, 1.50c. asked. Barcelona, direct, 1.50c. Japan, 1.25c. ,50c. are Vladivostok, i.zoc. LIVERPOOL.- By cable from Liverpool we have the fol¬ lowing statement of the week's sales, stocks, &c., at that port: 1. Exports from,— Stockholm, 1.50c. asked Rotterdam, 1.00c. ashed. Genoa, Bombay 3439 CHRONICLE THE 1920.] figures for Liverpool market for spots and futures day of the past week and the daily closing prices of each spot cotton have been follows: as 1918. OF Spot. COTTON.—The following are the receipts and shipments for Market, ALEXANDRIA the week RECEIPTS SHIPMENTS AND ending Nov. 12 and for the corresponding week previous years: of the two Saturday. 12 15 Mod rat - P. M. 1918. 1919. 1920. C 10.21 10.41 10.67 10.58 4,000 6,000 4,000 Market, Week. Aug. Liverpool To Manchester, &c To Continent and India. To America 1. Week. Aug. 78,113 39,864 30,589 11,792 6,755 6,460 1,060 25,430 3,000 135,849 19,932 4,500 63,793 900 41,041 31,313 8,283 20,500 74,844 5",332 1. Easy at x-7- 4 P. The 5,332 28,900 315,527 84,958 14,275 160,358 MANCHESTER MARKET.—Our Dec. Dec. 12M 17. ings, Common Mid. to Finest. 32s Cop Upl's Twist. Mon. d. a. s. d. Mid. to Finest. Upl's Twist. d. d. d. d. s. d. s. 22 32 @ 38 27 6 @30 0 15.73 45 @ 49 H 27 9 29 10@32 @32 9 12H 12M 8 Wed. Tues. 1234 4 1234 at 7@16 pts. decline. are given Thurs. 12 M 4 p. m.p, m. p. m. p. m. p. m. p. m. p. m. p. m d d. d. d. d. d. Fri. 12 34 4 p. m. p. m. p. m. p. m. d. d. 4 d. d. d. 11.25 10.52 10.46 10.40 10.66 10.83 10.92 10.98 10.83 10.82 11.2, 10.58 10.5 ... February 10.48 10.73 10.90 11.01 1L08 10 93 10.96 11.33 10.63 10.60 10.53 10.79 10.95 11.01 11.14 10 99 11.02 .. HOLI¬ 11.37 10.68 10.65 10.58 10.87 11.02 11.13 11.21 11.08 11.10 DAY. March April May 11.36 10.70 10.68 10.62 10.91 11.05 11.16 11.24 11.12 11.13 11.35 10.71 10.72 10.65 10.95 11.10 11.21 11.27 11.18 11.17 June 11.32 10.70 10.72 10.67 10.96 11.10 11.21 11.28 11.20 11.18 — July 11.30 10.69 10.72 10.69 10.97 11.11 11.22 11.29 11.23 11.20 August 11.22 10.63 10.67 10.63 10.91 11.04 11.16 11.24 11.18 11.15 11.13 10.58 10.63 10.59 10.84 10.98 11.09 11.17 11.11 11.10 - 11.04 11.53 10.58 10.54 10.79 10.93 11.03 11.12 11.06 11 05 ... in.0b 10.50 10.55 10.51 in. 7fi 10.90 11.00 11.09 11.03 11.02 _ MEMPHIS COTTON EXCHANGE CROP ESTIMATE. —The d. Quiet 15@20 pts. adv. adv. Cot'n 814, lbs. Shirt¬ ings, Common 32s Cop Steady at 39@45 pts. December.. November Cot'n Steady at January October 1919. 8H lbs. Shirt¬ adv. at 11 to September 1920. pt. advance. prices of futures at Liverpool for each day d. received by to-night from Manchester states that the market is weak for both yarns and cloths. The demand for both yarn and cloth is poor. We give prices for to-day below and leave those for previous weeks of this and last year for oomparison: report 1 2@9 pts. below: 211,993 cantars and the foreign shipments 5,332 bales. cable 12 pts. dec. tc dec. Dts. Quiet Quiet at 7@13 adv. pts. dec. Steady, 47@81 M. Sat. Total exports. Note.—A cantar is 99 lbs. Egyptian bales weigh about 750 lbs. This statement shows that the receipts for the week ending Nov. 24 were pt". pta. dec. 29@36 1@10 dvC. Dt8, Quiet at Quiet at 11@15 [ opened Since Since Week. Aug. 1. Since d. Quiet. 3,000 Quet at Market 242,099 2,252,217 300,000 2,709,013 211,993 1,508,165 Exports {bales)— •Oct. Mere demand. DAY. Futures. week Since Aug. 1 To Friday. 6,000 HOLI¬ | Nov. 24, J Quiet. Thursday. 11.00 Sales..... Receipts (cantars)— This Dull. ■ Wednesday. demand. Mid.Upl'ds Alexandria, Egypt, Tuesday. Monday. d. 22.68 32>* @ 40 H 26 6 @29 6 16.55 45 @ 60 27 5 35 @ 40 26 6 @29 6 15.55 46 @ 52 30 0 @34 6 25.50 @35 0 24.93 10^ 24.25 Nov. 12 32 @ 37 26 @29 0 14.56 48 H @ 52 30 6 19 29 @ 35 25 0 @27 6 12.41 47 H @ 54 H 30 6 @35 6 2814 @ 33H 24 0 @26 6 11.23 48H @ 55 K 30 6 @35 6 25 @ 30 22 6 @24 6 10.46 49 X @ 57 31 0 @30 0 24 @ 29 21 6 @23 6 11.42 50 H @ 59 34 0. @38 0 24 @ 29 21 0 @23 0 10.58 52 @ 61H 35 0 @39 0 26.1 the Memphis Cotton not nearest estimate to general average, 12,420,000. highest estimate, 13,675,000; 25.9o 17 of 12,458,273; 11,000,000; linters 25.47 10 members lowest estimate, 24.58 3 the of to the actual growth of cotton crop of 1920-21, included: General average of 122 estimates, as 23 75 26 estimate Exchange 6 BREADSTUFFS Dec. SHIPPING NEWS.—As shown previous, page, the -exports of cotton from the United States the past week have reached 121,935 bales. The shipments in detail as made up from mail and telegraphic returns, are as follows: on a •' NEW YORK—To Hamburg—Dec. 15—Mongolia, 213. To Piraeus—Dec. 14—River Orontes, 1,125 To — Bales. 213 1,125 Japan—Dec. 13—Ceylon Maru, 40. 40 •GALVESTON—To Liverpool—Dec. 11—Bassam, 9,893 —I 9,893 To Manchester—Dec. 11—Asuncion de Larrinaga, 12,914 12,914 To Bremen—Dec. 11—Isolde, 2,354--.Dec. 15—-Cardiganshire, 13,093: Holmburg, 5,140 20,587 To Hamburg—Dec. 11—Isolde, 150...150 - _ — — To Antwerp—Dec. 10—Skipton Castle, 1,650---Dec. 15— Peekskill, 1,325. To Ghent—Dec, 10—Skipton Castle, 4,108—.Dec. 15—Peekskill, 765 — - To Barcelona—Dec. &—Mar Caspio, 9,181 11—Gonzaga, 5,970 1.5—Cardiganshire, 1,235 - — To Rotterdam—Dec. — "TEXAS CITY—To Mexico—Nov. 3,300 NEW ORLEANS—To Liverpool—Dec. 15—New Columbia, 12.260 To Manchester—Dec. 10—WestErrai, 5,099 To Gothenburg—Dec. 10—Bogstad, 615 To Malmo—Dec. 10—Bogstad, 200 To Mexico—Dec. 15—Lake Dancey, 1,272— To Cuba—Dec. 15—Morganza, 42 To Japan—Dec. 4,873 Dec. 10—Clark Mills, 9,190._ To Genoa—Dec. 2,975 15—Kentucky, 13,726 18,371 5,970 1,235 3,300 12,260 5,099 615 200 1,272 _ 42 13,726 4,000 — WILMINGTON—To Bremen—Dec. 15—Mar Tirreno, 4,000 BALTIMORE—To Hamburg—Dec. 3—Wauconda, 200 To Barcelona—Nov. 30—West Lashaway, 200. SAN FRANCISCO—To China—Dec. 11—Venezuela, 100— SEATTLE—To Japan—Dec. 10—KashimaMaru, 1,100 TACOMA—To Japan—Dec. 11—Manila Maru, 1,475 — — — 200 200 100 1,100 1,475 121,935 The particulars of the foregoing shipments for the week, arranged in our Great Britain, New usual form, Germany. York as 1,125 200 9,083 ____ 13,726 4,000 400 100 1.100 „„ 1,100 1,475 1,475 40,166 25,150 18,571 9,898 7,095 16,441 4,614 121,935 been dull as Some advance ever. impression in the flour trade. in wheat The fluctuations eiratic, and often so violent that buyers are They seem skeptical as to the stability of wheat prices. And most other commodities are declining. Why, it is asked, should flour be exempt? On the other hand, trade has been quiet so long that it suggests that stocks throughout the country have become reduced. More¬ over, should the general business situation in this country brighten, it would, no doubt, be the signal for better times in the flour trade, especially if it should turn out that America has been overexporting wheat as 3ome believe she has. Later in the week rising wheat prices gave flour for the time a steadier tone, but buyers held off and on the 15th inst. came a drop in wheat of 5 to 6 cent3. It was the old story. To-day's advance in wheat had a tendency to steady flour prices, but trade remained for the most part quiet. Minneapolis wired Dec. 13: "Flour millers have made an¬ other sharp cut in products, registering new low levels. All grades of wheat flour are off 80c. a barrel to $8 70." Wheat advanced 10 cents and" then reacted 5e. by the in wheat are so still hesitant. Large export buying put up prices. And the passed the bill reviving the War Finance Corpora¬ This had a noticeable effect. The value of the 15th inst. Senate has tion. country's various crops including wheat and other grain is $5,000,000,000 less than last year, i. e., from $14,087,995,000 last year to $9,148,419,000 this year. With wheat down far below what it was and retail prices still up and the cost of living therefore high the fanner demands relief of To further his market in foreign parts would of help greatly. American exports are of course far sort. course Total. 1,378 76,968 3,300 33,214 100 Tacoma Total 3,300 1,314 200 Francisco ^Seattle 40 5,970 815 made little some Europe- Jap. A Mex. Spain. North. South. China. & Cuba. 213 Baltimore follows: -Oth. Galveston.__-22,807 20,737 18,371 Texas City... New Orleans. 17,359 Wilmington.. 4,000 San are Friday Night, Dec. 18 1920. has Flour ahead of those of a year ago. Some even take the ground country has already over-exported »and will feel the fact later on. But parts of Europe are said to be starving and what is to be done?* On the 13th instant and 14th that this stated at 1,250,000 bushels Germany, Spain, Portugal, and Italy. Belgium bought 120,000 bushels of Manitoba. Severe storms at the West interfered with ordinary trading instant the sales for export were It was taken by Belgium, in all. THE 2440 CHRONICLE The rally in stocks on the 14th instant wheat and on the loth money fell to 6%. Stress is laid on the strong statistical position. An increase of 5,304,000 bushels in the visible supply had little or no effect. The gains were largely at Buffalo and were believed to include large quantities of Canadian wheat in transit for Europe.. The reports from the West to the effect that progress has been made in the organi¬ zation of the export corporation with a capital of $100,000,000 and a potential credit of $1,000,000,000 had a good effect. There were reports of further heavy rains in Aus¬ tralia and London reported that Danish mills are overstocked with native wheat, which is rapidly deteriorating under humid weather conditions. Meanwhile the visible supply early in the week. had a more less bracing effect on or in the United States after increase of 5,000,000 bushels is still only 48,411,000 bushels against 84,684,000 a even an The U.S. Government report of Dec. 14 stated the winter at 580,513,000 bushels, crop for five against as an average 1914 to 1918 of 563,498,000 bushels. The spring wheat crop is 209,365,OCX) bushels, against an average for five years of 258,748,000 bushels. Total, 789,878,000 bushels, against 934,265,000 bushels in 1919. This is an increase this year over the earlier estimates of 39,230,000 bushels. It means an addition to the exportable surplus of nearly 40,000,000 bushels. This caused selling and years from decline of 6 to 7 cents at the time. a supply is 32,474,000 bushels, against year ago. The cash demand, more¬ Country offerings, too, have latterly been on a fair scale. Speculation is not brisk. What there is is largely monopolized by wheat and to some extent by corn. The speculative public is paying no great atten¬ tion to oats. To-day prices were higher, but end irregular for the week; i. e., December up a trifle and May lower. 14,846,000 bushels a over, has been small. DAILY CLOSING PRICES Broomhall cabled from Liverpool: "It must be admitted that the economic position in Europe is bad, but there are encouraging signs of improvement in the situation unless the Bolshevik wave stops production. The European living standard, especially as regards bread, at the present time is distinctly below that of pre-war days. In consequence wheat requirements are naturally reduced, owing to the large use of substitutes, and this fact should tend to keep down the price of wheat, while on the other hand, the world's supply of other grains is too abundant for dearness. The British Government is seriously bent on decontrolling millers in the United Kingdom in February. In addition, the Government also wishes to disband the Wheat Commission at the earliest possible date. Officials are now conferring with traders to arrive at a No. 2 white. — 64 . operandum." Reports from Argentine indicate the 1921 grain crop will exceed that of 1920 and 1919, but the amount available for export will be reduced on account of small carryover. To¬ day's Government report put the condition of winter wheat just planted at 87.9% against 85.2% last year, 98.6% in 1918 and 79.3% in 1917; acreage sown 40,605,000 against 41,757,000 last year, 50,489,000 two years ago and 42,301,000 in 1917-18. The ten-year average condition for December is 88.4%, so that the present condition is .5 of 1% under it, or, to all intents and purposes, equal to that average. Trading in May wheat began on the 15th inst. in Chicago. Export sales of late have been large. To-day prices advanced 6c. and end 6@,10c. higher for the week. CLOSING PRICES OF WHEAT Sat. No. 2 red DAILY PRICES OF ______ 191% Tues. 170% 164% 168% 161% 159 __ / .... cts. Thurs. 191 Fri. DAILY CLOSING PRICES Wed. 165if 164% 158% 152% 158 152% RYE 62 62 62 IN CHICAGO. Wed. Thurs. Fri. 45% 47% The FUTURES Mon. following 45 46 47 48% 157 143 Oats— No. 2 red No. 1 No. 1 No. 2 white 52 02 Nominal spring 62 62 No. 3 white Corn— No. 2 yellow 10 98% No. 2 61 ... BarleyFeeding Malting Rye— 1 77 89(3 ... .... 95 99(2 108 FLOUR. $9 25 $8 75® Spring patents. Winter straights, soft 8 25® Hard winter straights 8 75® Clear 9 00 9 25 7 25® 8 50® Rye flour 7 75 9 25 Barley goods—Portage barley: No. 1 $6 75 Nos. 2,3 and 4 pearl 7 00 Nos. 2-0 and 3-0... 6 75® Nos. 4-0 and 5-0— Oats Corn goods, 100 lbs.: Yellow meal 2 25@: 2 40©: Corn flour.. 50 6 90 7 00 goods—Carload spot delivery...... 6180 60 The statement of the movement of breadstuffs to market indicated below prepared by us from figures collected by Exchange. The receipts at Western lake and river ports for the week ending last Saturday and since Aug. 1 for each of the last three years have been: are the New York Produce Flour. Receipts at- Corn. Wheat. 889,000 . Oats. 224,000 1,099,000 379,000 605,000 102,000 100,000 201,000 204,000 157.000 274,000 33,000 291,000 37,000 1,640,000 Milwaukee-.. Rye. Barley. bush. 32 lbs. bush ASlbs. bvsh.5Qlbs. 992,000 1,792,000 181,000 ----- Duluth 164% 158% increasing 152% 137% GRAIN. Wheat— Detroit. _...v the slowness of the cash business and indica¬ CHICAGO. Thurs. Fri. 152% 138% 155% 143% closing quotations: are Toledo was IN Wed. Tues. ...cts.154% 154 140 142 May delivery.. 170 crop movement soon, notably from of Illinois. The visible supply decreased last week 158,000 bushels against an increase in the same week and OF Sat. December delivery.. Minneapolis. CHICAGO. Thurs. Fri. rainy. That fact indeed counted for more at that time than anything else, as delaying marketing. Some 50,000 bushels were taken for export early in the week. The trouble on the other hand has been the depression in Iowa 47% 50% 62 62 Rye advanced partly in response to the rise in wheat. Besides exporters bought and the cash position was firm. On the 14th inst. the Government crop estimate was 69,318,000 bushels, or 8,500,000 less than the preliminary estimate. Nevertheless prices dropped on that day 23^ to 5 cents, in sympathy with other grain. Cash premiums here, however remained firm at that time, braced by export sales of about 150,000 bushels. The barley crop is put at 202,024,000 bushels. The Government report to-day puts the condition of rye at 90.5% against 89.8% last year, 89% in 1918, 84.1% in 1917 and 91.2% as the ten-year average, so that the present condition is only 1.7th of 1% under that average. An unofficial estimate of the rye crop based on the present condition is 68,000,000 bushels, against 69,318,000 last season, 88,909,000 two years ago, and 91,041,000 in 1917-18. To-day prices rose and end 4 to 5c. higher for the week. Chicago 202 IN advanced though acting rather cool towards the rise in wheat. Still cash interests at the West did buy. So did December shorts. Besides, the weather at the West Wall Street, tions of an Fri. Thurs. 62 Tues. 46% 49% YORK. Wed. 64 Mon. 46% 49% bbls.imbs. bush. 60 lbs. bush. 56 lbs corn early in the week 64 Sat. December delivery May delivery 295,000 99,000 258,000 58,000 63,000 42,000 69,000 48,000 839,000 112,000 ' St. Louis. 334,000 468,000 43,000 92,000 19,000 326,000 188,000 29,000 30,000 1,317,000 114,000 58,000 412,000 Peoria Indian NEW DAILY CLOSING PRICES OF OATS FUTURES YORK. Wed. 199% FUTURES Mon. cts.165 delivery May delivery Tues. 194% WHEAT Sat. December delivery March NEW Mon. __cts.l89 _ CLOSING IN IN Mon. .Tues. 64 64 64 modus DAILY OATS OF Sat. No. 1 white over year ago. wheat visible The cents. [VOL. 111. 125,000 123,000 62,000 49,000 ... Kansas City.. Omaha 19,000 686,000 120,000 8,511,000 3,085,000 2.839,000 Indianapolis.. Total wk. '20 Same wk. '19 Same '18 325,000 424,000 428,000 1,263,000 636,000 5,787,000 4,795,000 2,762,000 573,000 399,000 13,053,000 5,711,000 7,146,000 2,250,000 1,618,000 5,116,000 173,183,000 wk. 61,286,000 Since Aug. 1— 1920 1919 9,097.000 253,118,000 1918 parts ... Total ^ 6,935,000 291 ,964,000 92,915,000 20,678,000 15,220,000 63,470,000 98,748,000 35,214,000 14,593,000 88,891,000 149,145,000 32,107,000 19,229,000 receipts of flour and grain at the seaboard ports for the week ended Dec. 11 1920 follow: last year of 272,000 bushels. But the total is still 4,439,000 1,903,000 last year. If there is to be a bushels, against larger crop movement with trade slow, it looks as though prices may have to decline. The Government report puts the crop at 3,232,367,000 bushels. This is a high record yield, and'on the 14th inst., when the estimate appeared, prices fell 3 to 33^ cents. New cash corn on that day was 2 to 5 cents lower at Chicago and in some cases old corn fell 8 The cash trade has dwindled to almost nothing cents._ for the time being. To-day prices advanced and ended 1 higher for the week on December and lower for May. DAILY _ CLOSING PRICES ---cts. DAILY CLOSING PRICES Mon. 98% 101% OF CORN Sat. _ December delivery cts. May delivery NEW YORK. Tues. Wed. Thurs. 68% 71% Oats fluctuated within very 102 Tues. 97% Thurs. 70% 71% 68% 67% 72% 69% 68 narrow 98% Fri. 69% 71% downward of rise in wheat and corn and also because of supply of 629,000 bushels, although the decrease was 1,001,000 bushels. There seems year ago be at least a a fair-sized short interest. fell off 424,000 bushels and is Chicago's stock now 11,411,000 bushels. The estimate on the 14th inst. by the Government was 1,524,055,000 bushels, or nearly 80,000,000 bushels larger than the preliminary estimate. It caused a drop of 2 to 2^ crop New Oats. Barley. Bushels. Bushels. York... Philadelphia Baltimore . _■... 56,000 3,437.000 54,000 974,000 9,000 865,000 34,000 62,000 532,000 42,000 166", 000 219,000 74,000 29,000 ^Rye. Bushels. 266,000 130,000 186,000 4.000 4,000 69*666 764,000 37,000 23", 000 1,114.000 125,000 392,000 7,618.000 143,000 Since Jan. 1 '19 13,027,000 246,176,000 19,736,000 904,000 450,000 26,840,000 10,995,000 49,811.000 150,000 3,111,000 803,000 Since Jan.1 '19 15,341,000 216.474.000 100,778,000 69,866,000 57,403,000 29,446,000 Newport News New Orleans a Galveston.... Montreal Total wk. '20 Ur on XWtVAJlj/jO U»J UOli 1UU1UUO 88*666 is'ooo 262*666 fc»x &IU 590,000 832,000 435,000 303,000 vXAA through bills of lading. The exports from ending Dec. 11 are the several seaboard ports for the week shown in the annexed statement: New York Boston... Wheat. Corn. Flour. Oats. Rye. Barley. Bushels. Exports from— partly in mild decrease in the visible to Corn. Bushels. limits, paying little the sharp movements upward or Some advance occurred at one time, sympathy with a a Wed. 72% regard to wheat. 97% Fri. FUTURES IN CHICAGO. Mon. Wheat. Bushels. Week 1920... OF CORN IN Sat. . No. 2 yellow . Flour. Barrels. Receipts at— Bushels. Barrels. Bushtls. Bushels Bushels 2,917,644 Peas. Bushels 921,827 339,553 134,763 128,578 45,000 80.000 2,079,000 52*666 738,000 60,000 32,000 4,000 1,641.000 47,000 Galveston 52*666 4,000 New Orleans 43",000 8,000 1,907,000 Philadelphia Baltimore Newport News Montreal Total 215,000 week Week 1919 163,000 183,000 36",000 25.000 110,000 10,000 66,000 149,000 91,000 427,827*833,553 9,581,644 2,977,763 259,378 18.000 512,896 4,1594,860 894,378 181.959-251.125 *5*628 Dec. 181920.] The destination of these exports for July 1 1920 is CHRONICLE THE the week and since many retailers below: as 2441 who have kept their prices up in order to advantage of the holiday trade will be forced to cut take prices materially early in 1921, and that manufacturers in Corn. Wheat. Flour. turn will find it necessary to keep prices low in view of diminished buying power all over. There have been many Exports for Week and Since Week • July 1 to— Dec. Since Week Since July 1 Dec. 11. July 1 Dec. 11. 1919. 1926. 1920. 1920. , . 11 1920. Week > Since July 1 buyers in the markets this week, evidently ready to pick odd lots when offered at low prices. As they are buying 1920. up Barrels. Kingdom. 77.905 Continent 140,894 13,579 259,378 7,102.684 So. & Cent. Amer. 15,000 West Indies 12,000 Brit.No.Am.Cols. Other countries Total 229,000 1,730,558 2,367,669 177,691 116,072 41,270 666,399 29,769 12,342 2,494,760 "a'ooo 3,000 39", 999 3,279",355 9,581,644 182,520,492 Total 1919....... 512,896 10,804,268 Bushels. Bushels. 757,788 62,364,185 8,554,857 114,379,192 1,826,349 3,321,357 633,757 452,807 2,000 866,414 ... Bushels. Bushels. Barrels. United 4,694,860 4,848,007 1,301,320 297,763 91,253.769 18,000 The world's shipment of wheat and corn for the week ending Dec. 11 1920 and since July 1 1920 and 1919 are shown in the following: generally for immediate shipment only, it is quite evident that stocks in many places have been well cleaned up. The auction of overcoatings shows that buyers expect low prices, and that they can get them, some goods being secured at prices fully 60% below the season's opening prices. The auction of difficult 1920. 1919. Week Dec. Since 11. July Since Since 11. July 1. July 1. Bushels. Bushels. Bushels. Week Since Dec. July 1. Bushels. Bushels. North Amer. 7,606,000 218,767,000 170,585,000 753,000 5,773,000 166,000 "635", 000 224",000 76,545,000 13,286,000 8%, mostly the latter. 1,424,000 India Oth. countr's 280,000 Total visible 58,909",000 l","75~0",666 the COTTON market 4,127.000 99,186,000 61,412,000 supply of grain, comprising the stocks in at principal points of accumulation seaboard ports Dec. 11 1920 was as follows: granary and at lake United States— bush. New York.... Boston.. Rye. bush, Oats. bush. bush. 6,017,000 .... -312,000 1,261,000 1,087,000 307,000 1,000 20,000 Barley. bush. 259,000 ... 470,000 2,265,000 40,000 276,000 29,000 10.000 Baltimore........ 2,973,000 576,000 462.000 766,000 287,000 . 4,000 ....... New Orleans 4,621,000 Galveston. 127,000 3,753,000 4.907,000 _____ Buffalo 4,000 ...... 354,000 159,000 ...... ...... 2,756.000 ...... 26,000 ...... 482,000 3',560.000 Toledo.. 911,000 Detroit. ._.... 52,000 19,000 . 31,000 ........... Chicago....... 1,497,000 afloat 121.000 565,000 Minneapolis 91.000 ...... Kansas City ..... 80,000 132,000 2,506,000 11,000 St. Louis.._L. 167,000 85,000. Indianapolis 151,000 On Lakes ______ 481.000 1,001,000 Omaha 202,000 4,442,000 ... On Canal and River Total Dec. 11 Total Dec. 1920....48,411.000 4 1920....43,107,000 13 Total Dec. 14 1918...111,255,000 1919 84,684,000 ...... 380,000 ...... ....... 993,000 101,000 117,000 2,260,000 151,000 82,000 7,380,000 872,000 1,503,000 62,000 17,000 79,000 1,359,000, 411,000 1,000 448,000 1,169,000 1,000 103,000 257,000 150,000 _..... 110.000 Total Dec. 2,000 44,000 7.963,000 317,000 Peoria 13,COO 251,000 742,000 .... 916,000 4,439,000 32,474,000 3,877,000 4,597,000 33,103,000 4,320,000 1,903,000 14,846,000 17,249,000 2,477.000 28,732,000 12,659,000 14,000 ...... 32,000 3,800,000 3.501,000 3,018,000 6,983,000 Buffalo; total, 35S.000, against 1,050,000 bushels in 1919; barley, New York, 29,000; Duluth. 1,000; total, 30,009 bushels, against 279,000 bushels in 1919. Canadian—r J 237,000 96,000 Ft. William <ft Pt. Arthur. 10,954,000 Other Canadian Total Dec. 11 ...... 4,690,000 525,000 1,000 3,563,000 2,735,000 55,000 968,000 404,000 1920 15,881,000 96,000 6,823,000 1,000 1,427,000 4 1920 18,828,000 140,000 6,411,000 1,000 1,271,000 Total Dec. 13 1919.... 16,159,000 Total Dec. 14 1918....24,071.000 ...1.. 4.520,000 44,000 3,800,000 3,000 434,000 4,439,000 32,474,000 3,877,000 1,000 3,800,000 1,427,000 Summary— * American Canadian 48,411,000 .....15,881,000 — Total Dec. 11 1920 96,000 6,823,000 64,292,000 4,535,000 39,297,000 5,227,000 61,935,000 Total Dec. 13 1919...100,843,000 4,737,000 39,514,000 4,772,000 Total Dec. 4 1920 Total Dec. 14 1918...135,326,000 burden¬ are some 3.878,000 4,321,000 1,903,000 19,366,000 17,293,000 2,668.000 32,532,000 12,662,000 4,152,000 7,417,000 rather a improvement, slow both as At the outset the tone trading quiet, was as to was inquiry demand was said to be of better firmer feeling developed, especially among Various large consumers were displaying in print cloths, sheetings, and other un¬ bleached cottons, and seemed more disposed to negotiate if reasonably sure that prices would be stable. There were large sales, but it was clear that stocks in many cases no ascribed in some The firmer attitude of mills was had made quarters to claims that they fairly large sales at some were Inquiry for finished goods also broadening tendency and the movement is evi¬ a dently gaining steadily. less a recent low prices, and hence disposed to accept further business on such levels. Gray goods sold in small lots early in the week for Decem¬ delivery, and later fair sales were made to printers and others for deliveries running into March. were At 38^-inch, 64x60s were freely offered at 8c., but not wanted above 7%c. Second-hands then sold Dec.- Jan. goods at 7%c., but later asked 7%& the start Spot Southern goods later sold at 8c., with Eastern mills asking 9c. were for generally ^c. to y2 c. lower. Rids Bids of 5%c. were made generally fu¬ tures at 91,£c. Sheetings have been moderately active, job¬ bers being fairly steady buyers on a basis of 10c. for 4-yard 56x60s; o^c. for 32-inch 6.25s; and 12V2c. for 40-inch 48 squares. There was limited inquiry for organdies, the 68x 56, 11 yards, being held at 11c. There was little interest in combed lawns, sateens, twills, or dr ills, most of the business going to second-hands. A one-cent reduction in percale prices, 12y2c. being named for 4-4 64x60s, led to little busi¬ 27-inch, 64x60s for Dec., with 6c. or more Spot sales of 68x72s were made at 91/4c. and Sellers ness. think that future orders should come for¬ price is still too high. The continued delay in naming gingham prices is hampering printers who would like to have it fixed so that they may name final prices for spring. ward 1.134,000 211,000 Total Dec. interest more asked. ...... Note.—Bonded grain not Included above: Oats, 16,000 bushels New York, 342,000 Montreal a first-hand sellers. ...... .. 173.000 ...... 147,000 Duluth ...... 1,720,000 11,411,000 175,000 Milwaukee... Later the ber and January 365,000 " afloat no means GOODS.—After showed although steady, prospect. ...... Philadelphia............ Newport News by small way created the belief that .larger business was a in showed Corn. are On the other hand, Reports of slow collections had been greatly reduced. GRAIN STOCKS. Wheat, lots seemed to be broadening somewhat and fairly steady buying character and 1,812,000 8,030,000 272,198,000 301,141,000 The 91,914,000 "864",000 3,961",000 many all industries. generally in 52,199,000 184,000 __ 38,491,000 16,000 Argentina. Australia be to Commercial paper rates continue unchanged at 7% start, Russia. Danube..... to other way. any volume of business and prices. Bushels. said be liquidated and are 1919. 1920. 1. in move DOMESTIC ; There goods that have stocks of the finer quality goods are and -'Corn, to heard in Exports. general. more undesirable some. Wheat. sale policy to dispose of surplus goods is evidently becoming on this basis, but many buyers say the WOOLEN GOODS.—Inactivity has continued as the principal feature in the market for woolen goods. There has been a small demand to cover immediate requirements of tricotines, wise there Poiret twills, and plaid skirtings, but other¬ been no animation. Business is seriously has checked by the further curtailment in the cutting trade as result of the bad labor conditions. Realizing that the a naming of lower prices would have no effect as a trade stimulant under such abnormal conditions, mill agents have THE DRY GOODS TRADE. New As usual at this kets has season slow been shown no show York, Friday Night, Dec. 17 1920. business in rule mar¬ the present instance the customary pre-inventory quietude the week. by the great uncertainty regarding the future. Within the past month or more a great deal has been heard to what is to happen "after the turn of the year." To the disinterested observer there certainly seems to be suf¬ as ficient on possibilities in the future to justify extreme caution all sides. Many arguments have been heard prices should go still recent sharp declines. as to why lower or should advance after the In support of the latter it is pointed out that many buyers have been holding aloof until "after the turn of the year," and that when they do start to buy a shortage of goods will become manifest owing to the recent material curtailment of production. It is argued marked refrained from buying for so long that stocks in many cases have been reduced to dangerously low levels, suggesting that when the demand does appear it will be sufficient to absorb everything of¬ fered, and a good deal more besides. On the other hand, it is pointed out that the loss in buying power in the agricul¬ tural districts, owing to the sharp drop in the value of farm that jobbers and distributers have products, will become much more extensive, spreading all over the industrial centres as a result of the prospective ma¬ terial reductions in wages. Hence it is contended that disposition to press sales. As a consequence, prices material change; at least, among first-hand sellers, although lower prices have doubtless been accepted by sec¬ ond-half holders anxious to liquidate. was augmented a during primary textile In as no FOREIGN DRY GOODS.—Buyers of burlap have ued decidedly contin¬ indifferent, owing to present large accumula¬ for Decem¬ below spot quotations. These factors naturally encourage the be¬ lief that prices are destined to fall to still lower levels, al¬ though it is asserted that they are already below the cost of production. A slight interest has developed in goods for shipment during the first half of the new year, but buyers show no disposition to pay more than the prices quoted for December, whereas shippers ask a slight premium. Light weights on spot are quoted at 4.70 to 4.90 cents, and heavies tions, further arrivals, and the fact that prices ber shipment from Calcutta are nearly a quarter-cent 5.70 to at are 5.75 cents. for heavies. markets practically dead-locked condition of linen still in force. Although prices have already The is December shipments from Calcutta quoted at 4.50 cents for lights and 5.50 cents dropped sharply, buyers still have no faith that the bottom has been reached and generally refuse to anticipate future require¬ ments. Hence it has been possible only to move goods from stock, and these only when offered at a sacrifice. In spite of the efforts to fix minimum prices abroad, there are con¬ stant of good flax at lower prices, more being price-cutting among growers on the Continent. offerings heard of . THE 2442 [Vol. 111. CHRONICLE and Sir Adam Beck tiwX (Eat# j^tate way ~~ proposition was will sell certain of its properties to the Ontario HydroThe total 334. the purchasers will be approximately $32,810,040, this can be deducted a sinking fund of $75,040 to cost Va.—Commission Form of Government Voted.-—On Dee. 7 the people of Charlottesville voted in favor of a commission form of government. The majority Charlottesville, for the given the approval of the Ontariothe Toronto Rail¬ Electrie Commission and the City of Toronto. ITEMS. NEWS are Government and the Toronto ratepayers, but from existing in the railway's accounts, leaving a net purchase price of $32,735,000. T&£ Hydro Commission's share of the total price will amount to $25,838,745, divided as follows: Commission to be delivered to the Toronto Railway aggregating $2,988,528: $2,375,000 6% 20-year debentures, dated Dec. 1 1920, secured by a first mortgage on Toronto & York Radial Ry. property outside the City Debentures of Hydro Pa.™Voters Ratify Annexation Plan. —By a vote of nearly two to one the voters of Chartiers Township on Dee. 14 declared for annexation to the City of Pittsburgh. The vote was 815 for annexation to 439 against. The annexation of Chartiers Township will in¬ crease the population of Pittsburgh by 5,634, add about 20 square miles of territory and raise the property value approximately $5,116,000. Goldsboro, N. C.—Slate Supreme Court Holds That Sale of Bonds Below Par is Legal.—It is stated that the sale below par of $150,000 worth of bonds by the town of Goldsboro was validated by the State Supreme Court on Dec. 1 in an opinion which held the Act of the 1920 special session of the Legislature which authorized the sale below par as con¬ Chartiers Township, The stitutional. Raleigh "News and Observer" says: in the case of Pennington vs. Town of Allen wrote the opinion of the court Chief Justice Walter Clark and Associate Justice George Brown filed but the same question was involved Associate Justice W. R. Tarboro. while dissenting opinions. The case of Kornegay vs. Goldsboro was an action to restrain the sale of bonds of the city of Goldsboro at less than par. The special session of the General Assembly in 1920 passed an Act authorizing the sale of these bonds at less than par within four months after the ratification of the Act. In accordance thereto, the bonds were sold to the Wayne National Bank at 96, with accrued interest. Associate Justice Allen answered the objection of the plaintiff in . detail. The plaintiff first set up that the special Act of the 1920 legislature was in conflict with Article 8, Section 1, of the Constitution of the State, regulating the chartering of corporations by special Act. To this, the majority of the answered court that the Section of the Constitution in particular had clearly to "private business corporations and does not refer to quasi public corporations acting as Governmental agencies." That the Act was also In conflict with Article 8, Section 4, the court reference public or denied, with the opinion that if the position of the plaintiffs that the legis¬ lature has no power except to pass general laws, the enactment of all special laws relating to municipalities can be maintained, the General Assembly has no amend its charter or to confer other That the Act confers special privileges on one community which power powers. are not to incorporate a city, conferred on another and is therefore unconstitutional, the court the very section of the Consti7, which is quoted as authority, concludes with exception, "but in consideration of pubhc service." "Surely," says the court, "if this principle avails the railway and the electric company it wall be applied in behalf of the municipal corporation an agency of the State, created for the benefits of the public." The plaintiffs further contended that the General Assembly in the adoption of the municipal finance act which requires that all municipal holds is just as untenable for the reason that » tution, Article 1. Section this bonds be sold at not less than par, acted with constitutional authority, and the Wayne County Act is in conflict with the general law and should be But the court sweeps this contention to the winds when it points set aside. out that such position if it could be maintained, would withdraw from subsequent legislatures the right to repeal or amend legislation. The usury law which the plaintiffs held up proved no more substantial a hindrance, for the court maintains that the sale of bonds has been dealt with as a sale of chattels. Likewise, the contention that the special Act is not general in its application and that it permits the municipal corpora¬ tions of Wayne County to sell bonds at less than par when the same privilege is not granted other localities, is not sufficient to invalidate the bond sale, Associate Justice Allen holds. In the court's opinion "all that is required by the Constitution is that the Act shall apply equally to all persons within the a territorial limits described in the Act." The final contention that the bonds were advertised in the News and Observer which does not come under the classification of financial papers as required by the amendment to the Municipal Finance Act of the special session, the court dismisses with this comment: "But it is admitted that this paper in addition to publishing general news also regularly publishes news relating to financial matters and also publishes from time to time notices of proposed sale of municipal bonds of municipalities of North Carolina which is sufficient compliance with the statute. "The statute of 1920," the court's opinion concludes, meet . for rake-off by powerful combinations of capital which will be formed to depress the price of such bonds and it is in violation of our usury law and will inevitably force the repeal of that statue which for so long a time has been a protection to our people: for who will lend money to a farmer, merchant, or any other legitimate business at 6% if such towns as Goldsboro a»*e allowed to sell 6% tax-free bonds at from 4 to 6% below par, which privileges will be extended to other cities by special Act and we may see the sale price of municipal bonds brought down to a far lower figure still." » Characterizing the interpretation of the legislative Act as "extremely unfortunate" Associate Justice Brown adds in his dissenting opinion that this legislation "at one blow strikes down one of the most valuable amend¬ ments efforts ever made to of the our General Constitution. The decision is disastrous to the Assembly to maintain the credit of the cities and to^s of^e^S^tgJby forbidding the sale of securities below par." Xdaho.^—Amendment to Constitution Extending the Debt Limitation.—The voters of Idaho an on Nov. 2 State approved Consti¬ amendment to Section 2 of Article 8 of the State tution. The amendment extends the debt limitation so as to permit the State to control and promote the development of the unused water power within, the State. We print Sec. 2 of Art. 8 below, giving the new matter in italics: or Section 2, of Article 8: The credit of the State shall not, in any manner, be given, or loaned to, in aid of any individual, association, municipality or corporation; nor shall the State directly or indirectly become a stockholder in any associa¬ tion or corporation. Provided, That the State itself may control and promote the development of the unused water power within this State. Highway Bonds Voted.—At the election Nov. 2 an issue $2,000,000 bonds was voted for the purpose of construct¬ The vote on this question was 40,720 ing State highways. for to 30,901 against. of Public Ownership of Toronto Railway Properties Planned.—Approximately $10,000,000 Municipal Bonds Involved.—If plans completed by Sir William MacKenzie f the debts against the properties, aggregating $22,850,217: $4,335,000 5% First Mtge. bonds of the Electrical Development Co. of Ontario, dated Mar. 1 1903, now outstanding. $13,558,917 4M% 30-year debenture stock of Toronto Power Co., now outstanding. $4,103,200 5% mortgage bonds of the Toronto Power Co. maturing July 1 1924. $840,000 6 % 3-year promissory notes of Toronto Electric Light Co. $13,100 outstanding shares of Electrical Development Co. of Ontario. , m The City of Toronto as Ry. its share will deliver to the Toronto $6,97i,295 of its 6% 20-year bonds dated Dec. 1 1920. Further details concerning the an transaction will be found Dept." of this item in the "Railroad and Industrial issue. South Dakota.—Proposed Amendment to Constitution Defeated—The voters of South Dakota on Nov. 2 defeated the proposed amendment to Sec. 4 of Art. 13 of the State Constitution which would have empowered a school,district to exceed the 5% debt limitation. (V. Ill, p. 1772.) Washington (State of).—Result of Referendum on Sol¬ Bonds.—The voters of Washington on Nov. 2 approved the Soldiers' Bonus Measure by a vote of 224,356 for to 88,128 against. The Act authorizes the issuance of State bonds to the amount of $11,000,000 (V. 110, diers' Bonus and Highway 1771). p. bonds was against. The proposition to issue $30,000,000 highway defeated by a vote of 117,425 for to 191,783 v'^- ; Legality of Soldiers' Bonus.—It is stated that a friendly suit has been started in the State Supreme Court to test the legality of the Soldiers' Bonus Act. A special dis¬ patch from Olympia to the "Oregonian," dated Nov. 30, says: Suit to Test "To test the legality of the Soldiers' Bonus Act adopted by referendum general election Nov. 2, Attorney-General Thompson to-day filed in the Supreme Court petition, or a writ of mandate to compel State Auditor C. W. Cluasen to issue a warrant for the payment of $1,000 from the School Fund for a bond of like denomination issued by the State Board of Finance as administrator of the provisions of the bonus of the voters of the State at the Frank C. Owings The board, as bonds which it was proposed to issue, and then in its capacity as custodian of the permanent State funds, the board adopted a resolution to purchase from itself this $1,000 bond as an investment for that amount of the State Permanent School Fund, and ordered the State Auditor to issue a warrant for that amount. "A third resolution was thereupon adopted accepting the offer to purchase a $1,000 bond, the board, acting in its dual capacity, thus closing the formal transactions necessary to bring the constitutional test of the Bonus Act. The case, which is friendly, will be bill. argued Dec. 17. retained to represent Clausen in the test case. administrator of the bonds, offered for sale one of the $1,000 has been The State Auditor refused to issue the warrant, and was then filed direct in the Supreme Court. petition for mandamus Under the Act, these bonds to the 6% at less than par." be issued to raise the bonus money are made legal investment for Permanent School, Higher Education and Accident funds, will draw interest, and cannot be sold at discount or BOND CALLS AND REDEMPTIONS. Cascade __ "has been framed to pressing emergency and is of limited duration and as we find no Constitutional objection to its enactment, it must be sustained." In his dissenting opinion, Chief Justice Walter Clark says: "Not only is this special legislation authorizing the city of Goldsboro to sell its bonds below par in violation of the . . Constitution which requires equal rights to all and special privileges to none, it is in violation of the amendment passed for the express purpose of requiring uniform legisla¬ tion as to all municipalities, and in violation of the general Acts passed in pursuance thereof by the Legislature of 1917, but it is a serious discrim¬ ination against other towns and cities which are required to sell their bonds at not lass than par and tends to depress the price of all municipal bonds in the State with great loss to the tax payers and giving unlimited opportunity a Dec. I 1920, guaranteed by the Province of Toronto. The Commission to assume in of Kornegay vs. Goldsboro Tbe issue came before the court in the case of Toronto. $613,528 6% 20-year debentures, dated —On Jan. 1 CountyjfP. O. Great Falls), Mont.—Bond Call. 1 1921 $192,000 4% court-house bonds dated 1901 will be called for payment. John E. Moran is Jan. County Clerk. Dominican (Republic of).—Bond Call.—Arthur H. Mayo, Lieutenant Commander (SC), U. S. N. Officer Ad¬ ministering the Affairs of the Secretaria de Estado de Ha¬ cienda y Commercio for the Military Government has issued the following notice inviting tender of bonds: In accordance with Executive Order 272 sealed proposals will be received by the Secretaria de Estado de Hacienda y Commercio until 10 a. m. of Feb 1, Mar. 1, and April 1 1921, for the purchase for retirement of bonds of the Dominican Republic dated Jan. 1 1918, due 1938, without regard to series, to an amount estimated at $320,000 on each of the above dates, a total for three dates of $960,000 All proposals shall be submitted in triplicate and specify the number of the bonds offered, the series, the par value and authorized containing proposals shall appear the words "Proposals opening of" (fill in date). Said proposals will be opened in public in the office of the undersigned on Feb. 1, Mar. 1, and April 1 1921, unless such dates fall upon a Sunday or legal holiday, in which case the bids will be opened on the following day. shall the price at which offered and shall be signed by an official duly to act for the bidders. Upon the outside of the sealed envelopes Salt Lake City, Salt Lake Lake City County, Utah.—Bond Call.— refunding bonds dated Jan. 1 1901, totaling $500,000, bearing 4% interest and maturing Jan. 1 1921, is payable at the office of R. M. Young, City The issue of Salt Treasurer. All holders and others interested in the bonds of this issue are given this advice that no delay may be experienced in by erroneously forwarding them to New redemption. their redemption York for BOND PROPOSALS this week have been as AND NEGOTIATIONS follows: SCHOOL DISTRICT (P. O. Ada), Hardin County, Ohio.— OFFERING.—Proposals for $15,000 6% refunding bonds will be re¬ Dec. 22 by A. E. Warren, Clerk of Board of Education. Denom. $500. Date Jan. 1 1921Prin. and semi-ann. int. payable at the office of the Clerk of Board of Ed. Due Jan. 1 1926. Cert, check for ADA BOND ceived until 7 p. m. $200 required. „ ALACHUA COUNTY SPECIAL ROAD AND BRIDGE DISTRICT NO. 1, Fla.—BOND SALE.—The $310,000 5H % gold bonds, which were offered on Feb. 10—V. 110, p. 783—but then failed to receive a satisfactory • Dec. 181920.] THE CHRONICLE bid, have been purchased by the Kauffman-Smith-Emert & Co., of St. Louis. Denom. $1,000. Date Jan. 1 1920. Prin. and semi-ann. int. (J. & J.) payable at the U. S. Mtge. & Trust Co., N. Y. Due yearly on Jan. 1 as follows: $4,000, 1925; $5,000, 1926; $6,000, 1927; $7,000, 1928 and 1929, $8,000, 1930; $9,000, 1931 to 1933, incl.; $10,000, 1934 and 1935; $11,000, 1936 and 1937; $12,000, 1938 and 1939; $13,000, 1940 and 1941; §14,000, 1942; $15,000, 1943; $16,000, 1944; $17,000, 1945 and 1946; $18,000, 1947 and 1948; $19,000, 1949 and $20,000, 1950. Financial Statement. Estimated actual value of taxable propertv Assessed valuation of taxable property, 1920 Total bonded indebtedness, this issue ■ _ _ ___ $20,000,000 5,224,227 only. Population, estimated, 26,000. 310,000 ALBANY, Albany County, N. Y.—BOND OFFERING.—Elmer D. Gunn, City Comptroller, will receive bids until 11 a. m. Dec. 23 for any of the following 5% tax-free registered bonds: $300,000 school construction bonds. Denom. $1,000. Due $15,000 yearly on Jan. 1 from 1922 to 1941, incl. 60,000 city hall impt. bonds. Denom. $1,000. Due $3,000 yearly on Jan. 1 from 1922 to 1941, incl. 19,500 public bath impt. bonds. Denom. $1,300. Due $1,300 yearly on Jan. 1 from 1922 to 1936, incl. 16,200 public impt. bonds. Denom. $1,620. Due $1,620 yearly on Jan. 1 from 1922 to 1931, incl. 12,000 garage site purchase bonds. Denom. $1,000. Due $1,000 yearly on Jan. 1 from 1922 to 1933, incl. - Date Jan. 1 1921. Prin. payable at the City Treasurer's office; semiint. J. & J. payable by mailed checks. Cert, check for 2% of amount of bonds bid for, payable to Wm. J. Brennan, City Treasurer, required. Bonds to oe delivered on Jan. 5, or as soon thereafter as possible. The three last-described issues will be purchased by the Comptroller for the sinking funds. ann. ALPHORETTA SCHOOL DISTRICT (P. O. Alphoretta), Milton issue of 6)^% school bonds amounting $18,500 has been purchased by the Robinson-Humphrey Co. of Atlanta. Denom. $1,000. Date Nov. 1 1920. Prin. and semi-ann. int. payable in New York. Due yearly on Nov. 1 as follows: $500 1931 and $1,000 1932 incl. and $1,000 on April 1 and Oct. 1 in 1930, 1931 and 1932. check for $200, payable to H. A. Barth, City Treasurer, required. to the 1949 incl. Blount Tenn.—BOND OFFERING.—Bids (sealed B. Smith, City Recorder, for $25,000 6% coupon bonds until 7.30 p. m. Dec. 28. Denom. $1,000. Date Jan. 1 1921. Prin. and semi-ann. int. payable in gold, payable at the Bankers Trust Co., N. Y. Due Jan. 1 1941. Any successful bidder may, at the option of the city, be required to furnish a certified check payable to the City of Alcoa in a sum equal to 2% of the amount of bonds bid for. Bonds are registerable as to principal only. The Bankers Trust Co. of N. Y., will certify as to the genuineness of the signatures of the city officials. The prospective bidders will be furnished without charge the approving opinion of Gordon & Smith, attorneys of or County, sewer BARTHOLOMEW COUNTY (P. O. Columbus), Ind.—BOND SALE. —The $35,000 4Vz% T. N. Stewart et al Rockcreek and Ilawcreek Twp. road bonds offered on Oct. 30 (V. Ill, p. 1585) have been purchased by the contractor. Due $1,750 each six months from May 15 1922 to Nov. 15 1931 incl. BELLVILLE INDEPENDENT SCHOOL DISTRICT (P. O. Bellville), Austin County, Tex.—BONDS REGISTERED.—The State Comptroller on Dec. 6 registered $12,000 5% 5-40 year bonds. BELTRAMI COUNTY (P. O. Bemidji), Minn.—PRICE PAID.—'The Northern National Bank of Duluth, representing Field, Richards & Co., of N. Y., paid par on Dec. 8 for the $250,000 6% tax-free coupon road bonds (V. Ill, p. 2347) which are described as follows: Denom. $1,000. Date Dec. 1 1920. Prin. and semi-ann. int. (J. & D.) payable at the Equitable Trust Co., N. Y. Due Dec. 1 1930. Financial Real valuation of taxable property Assessed valuation (1920) Utah—CORRECTION.—We are advised Mtge. Co. of Salt Lake City did not purchase an from this city on March 20. The item in V. 110, p. 1553, stating that the said bonds were sold to mentioned company, was evidently incorrect. BONDS.—The $50,000 water and the $9,000 light 6% 5-20 year serial bonds, which were sold on March 20 to the Palmer Bond & Mortgage Co. of Salt Lake City—V. 110, p. 1553—answer the following description: Denom. $1,000. Date May 1 1920. Int. M. & N. CENTER SCHOOL TOWNSHIP (P. O. Indianapolis), Marion Coun" t5r» 1 nd.—BOND SALE.—The $95,000 6% school bonds offered on Dec. 13 .....$30,000,000 12,000,000 To^al bonded debt (including this issue) Sinking _. funds. _____ 2,747,310 300,000 519,500 _____ Due $9,500 yearly on Dec. 15 from 1921 to 1930, incl. the bidders: Merchants Nat'l Bank..$96,117.80 Fletcher Savings & Trust F. Wild & Co., Indian. 96,027.00 Co., Indianapolis $95,226.53 Meyer-Kiser Bk, Ind 95,810 25 Peoples State Bank 95,210.00 CHANDLER SCHOOL DISTRICTS which were voted on tion: BERKELEY HIGH SCHOOL DISTRICT, Alameda County, Calif.— AWARDED IN PART—Of the $492,000 5% school bonds, offered without success on Aug. 9—V. Ill, p. 911—$218,000 have been disposed of, it is reported. BONDS OF BONDS Nov. 6—V. Ill, p. 2064 DRAINAGE DISTRICT NO. 1, Forsyth semi-annually. Due in 20 years. COEUR D'ALENE, Kootenai Dec. County, SALE.—On Ida.—BOND 13 the $9,000 municipal bonds—V. Ill, p. 2347—were awarded at for 6s as follows: $4,500 bonds to the First Exchange National Bank, Coeur D'Alene. 4,500 bonds to the American Trust Co., Coeur D'Alene. par COHN CENTRAL CONSOL. RECLAMATION DISTRICT, No. 761 Kings County, Calif.—BOND SALE.—This district awarded $118,000 6% bonds to E. H. Rollins & Sons. The bonds mature from 1926 to 1930. COLEMAN COUNTY (P. O. Coleman), Tex.—BONDS REGISTERED. —A $400,000 5H% serial bond issue Comptroller. registered was on Dec. 6 with the State CONTINENTAL. Putnam Paul R. Mootz, Village Clerk, $2,000 6% coupon County, OFFERING.— Ohio.—BOND will receive bids until 10 a. refunding bonds. Denom. m. Jan. 2 for Date Jan. 1 1921. $500. Prin. and semi-ann. int. payable at the Continental Bank of Continental. Due $500 yearly on Jan. 1 from 1925 to 1928, incl. Cert, check on a solvent bank in Putnam County, for 5% of amount of bonds bid for, re¬ quired. CRANSTON (P. O. Providence), Providence County, R. I.—NOTE SALE.—After receiving no bids, the city negotiated a private sale of the $382,000 refunding and $50,000 fire-station notes offered on Dec. 14 (V. Ill, p. 2348). Date Dec.. 15 1920. Due June 15 1921. CROOKSTON, Polk County, Minn.—BOND SALE.—The bid of par, which was submitted by M. R. Hussey and John McDonnel, both of Crookston, jointly, on Dec. 14 for the purpose of obtaining $2,658 25 6% 6% coupon sewer bonds—V. Ill, p. 2248—was accepted. • DAKOTA COUNTY (P. O. Hastings), Minn.—BOND OFFERING.— Downs, County Auditor, will receive sealed bids until Dec. 20 for road bonds.—V. Ill, p. 2348Date Dec. 1 1920. $250,000 5%% Due Dec. 1 1925. DAVIESS COUNTY (P. O. Washington), ind.—BOND OFFERING.— Vance, County Treasurer, will receive bids until 2 p. m. Jan. 4 $35,132 80 4Chas. A. Traylor et al, Harrison Twp. road impt. for bonds. Due $1,756 64 each six months from May 15 1922 to ncl, and Milton to W. $1,600 Shirley, Com¬ COUNTY (P. O. Nashville), Tenn.—BOND OFFERING —Sealed bids will be received until 9 a. Jan. m — DISTRICT SCHOOL (P. O. Big Stone Gap), Wise County, V a.—BOND OFFERING.—J. W, Kelly, Chairman Board of Education, will receive sealed bids until Jan. 1 for an issue of $35,000 school bonds. BISMARCK SCHOOL DISTRICT NO. 1 (P. O. Bismarck), Burleigh County, No. Dak.—BOND SALE.—The State of North Dakota during purchased $75,000 4% bldg bonds at par. Date April 1 1920. Due April 1 1940. Bonds are not optional, but can be paid up any time August after 2 years at par. tax-free county memorial bonds of 1919. 1920. Prin. and semi-ann in New York at holder's Denom. int. payable at the County option. Due yearly on Jan. 1 as follows: 1922 to 1926 incl., $8,000 1927 to 1931 1950 incl company Cert, check on a national as bank or upon any bank of said or trust Bonds by the U. S. Mtge. & Trust Co., N. Y. and legality Y., whose favorable opinion All bids must blank forms which will be furnished by the above official or said trust company. Jan. 1946 to principal in New York City will be prepared and certified to the genuineness be upon $4,000 incl., $12,000 1932 to 1938. incl., in Tennessee, for 2% of the face value of bonds, required. as to 1 Trustee's office or trust The bonds will be delivered in Nashville, company or in New York, at purchaser's option, at the office on or about 17 1920. The official notice of this bond offering will be found among the advertise¬ ments elsewhere in this DAYTONA, Department. Volusia County, Fla.—BID REJECTED.—The only bid, which was on G14% basis and submitted on Dec. 8 by W. L. Slayton & Co., of Toledo for the purpose of obtaining $450,000 5% bonds—V.111, p. 2248—was rejected. DICKINSON COMMON SCHOOL DISTRICT (P. O. Binghampton), Broome County, N. Y.—BOND SALE.-r-The $100,000 6% 1-20 year serial school bldg. offered on Dec. 15—V. Ill, p. 2248—were awarded to Sherwood & Merrifield of New York, at 100.15, a basis of about 5.98%. DEARBORN COUNTY (P. O. Lawrenceburg), Ind.—BOND OFFER¬ ING.—Proposals for $15,600 5% Wm. Grelle et al Caesar Creek Twp. impt. bonds will be received until 10 a. m. Dec. 22 by Gabeh L. Baker, County Treasurer. Denom. $390. Date Oct. 4 1920. Int. M & N. Due $780 each six months from May 15 1922 to Nov. 15 1931, incl. road BURLINGTON, Alamance County, No. Caro.—FINANCIAL STATEMENT.—In connection with the offering on Dec. 20 of the $47,000 6% water street impt. and sidewalk impt. 6% bonds, details of which p. 2347—we are now in receipt of the following financial statement. Assessed valuation Hickman, Date Jan. $1,000. $16,000 1939 and 1940; $20,000 1941 to 1945, incl., and $24,000 i; BRUNSWICK, Glynn County, Ga.—BOND OFFERING.—Sealed proposals will be received by J. Hunter Hopkins, Mayer, for $62,000 5% coupon refunding bonds until 3 p. m. Dec. 27. Denom. $1,000. Date Jan. 1 1921. Prin. and semi-ann. int. (J. & J.) payable at the office of the City Treasurer. Due Jan. 1 1951. appeared in V. Ill, 10 by Litton County Judge and Chairman of the Finance Committee, for $396,000 5% will be furnished the purchaser or purchasers without charge. BIG CREEK DRAINAGE DISTRICT, Tenn.—BOND SALE It is reported that a $250,000 20-year bond issue was recently purchased by Caldwell & Co., of Nashville at par and interest. GAP Nov. 15 1931, .-.V.:. approved, by Caldwell and Masslich of N. taxable property, 1920 $10,228,787 Bonds outstanding Floating debt Bonds offered for sale Dec. 20 1.920 No other indebtedness except temporary loans to be discharged by _ proceeds of said sale of bonds. Uncollected special assessments pledged to the payment of street bonds of larger amount— Sinking fund.... The City's Water System produced revenue in the last fiscal year over and above the maintenance and operation^ amount¬ to... 614,000 12,200 47,000 72,630 75,576 3,506 Indebtedness of Burlington School District None There is no other municipality or political subdivision whose limits are BUCYRUS, Crawford, Ohio.—BOND OFFERING.—Proposals will 12 m. Dec. 27 by Carl Young, City Auditor, for $16,551.60 6% coupon judgment bonds. Denom. 1 for $551.60 and 32 for $500. Date June 1 1920. Prin. and semi-ann. int. (A. <fe O.) payable at the City Treasurer's office. Due $551.60 April 1 1922; $500 on April 1 and Oct. 1 be received until 1912; $500 on April 1 and $1,000 on Oct. 1 in the years DECATUR, De Kalb County, Ga .— BOND SALE.—The $100,000 high school and $50,000 5% water works extension bonds, which were voted June 30—V. Ill, p. 215-^-have been sold to J. H. Ililsman & Co., of Atlanta. on DELAWARE TOWNSHIP (P. O. Sherwood), Defiance County* Ohio.—BOND OFFERING— E. II. Mohley, Township Clerk, will receive proposals for $44,500 6% road impt. bonds until 12 m. Dec. 20. Date Dec. 31 1920. Prin. and semi-ann. int. payable at the Sherwood Savings Bank Co. of Sherwood. Due yearly on Sept. 1 as follows: $1,600, 1921; $2,900, 1922; $4,500 in 1923, 1925, 1927 & 1929; and $5,500 in 1924, 1926. 1928 & 1924 to 1929, Cert, check for $500, payable Purchaser to pay accrued interest. 1930. required. practically coterminous with those of the City of Burlington. Population, 1920 census, 5,952. in of bonds following descrip- CHICAGO SANITARY DISTRICT (P. O. Chicago), Cook County, 111.—PRICE PAID.—The Harris Trust & Savings Bank of Chicago paid par for $730,000 and 97.69 for $1,000,000 when it bought the issue of 5% coupon (with privilege of registration) bonds described in V. Ill, p. 2248. registerable . 1932, incl. J. B, Durham, Commissioner, J. missioner, S. H. Allen, Commissioner. ing Maricopa issues two Denom. $1,000. 50,000 Grammar School District No. 80 bonds. Denom. $500. INT. rate 6%, payable 1924 STCNE Chandler), —The -bear the $170,000 High School District bonds. Counties, Ga.—BOND OFFERING—-The undersigned Commissioners of this district will receive bids at the Bank of Gumming, Gumming, until 12 m. Dec. 20 for $16,064 6% bonds. Denoms. 1 for $1,664 and 9 for $1,600. Date July 1 1920. Due yearly on Jan 1 as follows: $1,664, 1923 and BIG O. (P. County, Ariz.—DESCRIPTION DAVIDSON BERKELEY GRAMMAR SCHOOL DISTRICT, Alameda County, Calif.—BONDS AWARDED IN PART.—Ot the $429,000 5% school bonds which were offered unsuccessfully on Aug. 9—V. Ill, p. 911—$203,000 have been sold, it is stated. CREEK were J. Population (1920 Census), 27,510. BIG following Oliver M. Judicial ditch bds (Sec.by liens against property benefitted) Net debt $14,000 park bonds Oate Dec. 15 1920. The 3,566,810 Deductions— • -—v.. ill p. 2156—were awarded to the Merchants National Bank of Indianapolis for $96,117.80 (101.071) and interest a basis of about 5 62%. the (estimated).'. pay ^EDAR CITY, Iron County, ,, R. W. Statement. to that the Palmer Bond & Pittsburgh. ASBURY PARK, Monmouth County, N. J.—NOTE SALE.—Of the issue of $325,000 1-year impt. notes offered on Dec. 14—V. Ill, p. 2247— $100,000 were sold to the Asbury Park Trust Co. of Asbury Park at par for 6s. Cert, Bonds date of award, at the accured interest and furnish .Paid for within 10 days from office. s Purchaser necessary printed bonds. lsSm£ unsealed) will be received by A. funding and $125,000 Treasurer CAPE GIRARDEAU SCHOOL DISTRICT (P. O. Cape Girardeau), Cape Giradeau County, Mo.—BONDS VOTED.—On Dec. 1 the $54,000 high school bonds—V. 110, p. 2063—carried by 755 to 141. to ALCOA, delivered anci "e City County, Ga.—BOND SALE.—An to 2443 to the Township Treasurer, DICKINSON SCHOOL DISTRICT NO. 1 (P. O. Dickinson), Stark County, No. Dak.—BOND SALE.—An issue of $80,000 4% school bldg. was sold during September to the State of North Dakota at par. Date April 1 1920. Due April 1 1940. Bonds are not subject to call but can be paid up any time after 2 years at par. bonds DU PAGE COUNTY SCHOOL DISTRICT NO. 33 (P. O. West Chi¬ cago), 111.—BOND SALE.—The First Trust & Savings Bank of Chicago awarded at 106.035, a basis of about 5.35%, the $50,000 6% school-site and building bonds, offered on Oct. 28 (V. Ill, P- 1678). Date April 1 1920. Due $10,000 on April 1 in 1925 and 1930, and $15,000 on Oct. 1 in 1935 and 1940. was THE 2444 PALESTINE, Columbiana County, Ohio.— SALE.— reported that J, C. Devine & Co. of Alliance, have been awarded $10,000 5% 5 1-3 year (aver.) street impt. bonds at par. Int. F. & A. EAST It is EASTON, Northampton County, bonds, dated Dec. 1 1890, and maturing exchange them for bonds of the above issue. Dec. 1 1920, may INDEPENDENT CONSOLIDATED SCHOOL, DISTRICT NO. 1 (P. O. Egan), Moody County, So. Dak.—BOND OFFERING.— Sealed bids will be received by A. L. Dfckerson, Secretary Board of Educa¬ tion, on Jan. 5 at 2 p. m. at the First National Bank of Egan, for $150,000 20-year school bldg. purchase bonds at not exceeding 7% interest. Date Jan. 1 1921; Prin. and semi-ann. int. payable at some central banking point at the option of purchaser. Cert, check on some recognized bank of good standing for 5% of the amount of bonds bid for, payable to the said school district, required. Purchaser to furnish his own bond blanks and attorney's opinion. Bids will be received for the whole or any part of said bonds but in multiples of $100 only. EGAN EL CENTRO,, Imperial County, Calif.—BOND SALE.—The $15,000 6% municipal impt. bonds, offered on June 23—V. 110, p. 2587—have been sold to the City National Bank of Long Beach at par and interest. Date $49,473,146 332,500 —* Population, estimated, 23,000. HARRISON COUNTY (P. O. Corydon), Ind.—BOND OFFERING.— County Treasurer, will receive bids until 2 p. m. Dec. 27 4)4% Charles McCutcheon Blue River Twp. road bonds. De¬ $200Date Dec. 10 1920., Int. M. & N. Due $200 each six months May 15 1922 to Nov. 15 1936 incl. William Taylor, for $6,000 nom. from HARRISON COUNTY (P. O. Marshall), Tox.—BIDS'REJECTED.— received on Dec. 13 for the $828,000 5% road bonds—V. Ill, p. rejected, it is stated. The bids ranged from 84.50 to as low The bids 2065—were 82. as HARRIS TOWNSHIP, Franklin County, No. Caro .—BOND OFFER¬ 5 at the office of W. H. ING.—Bids will be received until 11 a. m. Jan. Yarborough, attorney, Louisburg, No. Caro., for bonds. Denom. $1,000. Date Nov. 1 1920. (M. & N.) payable at $500 required. $50,000 6% 30-year. road Prin. and semi-ann. int. the National Park Bank, N. Y. Certified check for HENDERSON COUNTY LEVEE DISTRICT NO. 2, REGISTERED.—An issue of $45,000 6% serial bonds was the State Comptroller on Dec. 6. Tex.—BONDS registered with HIGHLANDS, Macon County, No. Cmo.—BOND OFFERING— 3 bids will be received by Chas. E. Hefner, Town Clerk and $35,000 6% school bonds, it is reported. Until Jan. Due $375 yearly on July 2 from 1921 to I960 incl. July 2 1920. Financial Statement. ->■! Assessed valuation, 1919— Total debt, including this issue Pa.—BOND OFFERING.—M. B* Hulsizer, City Treasurer, is offering for sale an issue of $100,000 4)4% 30-year coupon sewer bonds. Denom. $100 to $500. Date July 1 1920. Due July 1 1950. A footnote on the official advertisement states that the holders of City of Easton 4% [VOL. 111. CHRONICLE Treasurer, for ELYRIA, Lorain County, Ohio.—BOND OFFERING.—V?. F. GuthCity Auditor, will receive bids until 12 m. Jan. 4 for $150,000 6% works bonds. Denom. $1,000. Date Sept. 1 1920. Prin. and semi-ann. int. (M. & S.) payable at the U. S. Mtge. & Trust Co. of New York. Due $10,000 yearly on Sept. 1 from 1931 to 1945, incl. Cert check for 2% of amount of bonds bid for, payable to the City Treasurer, required. 1 man, water NO. 16 P. O. Pensacola), Fla.—BOND SALE.—A. T. Bell & Co., F. C. Hoehler Co. and Tucker, liobison & Co., were awarded the $500,000 6% 1714 year (aver.) school bonds, dated Jan. 1 1921—V. Ill, p. 2156—on Dec, 11 at 98.33 and interest a basis of about 6.16%. ESCAMBIA COUNTY SPECIAL TAX SCHOOL DISTRICT 2 Snohomish EVERETT, County, Wash.—BOND OFFERING.— Until 10 30 a. m. Dec. 27 bids for the purchase of the $100,000 municipal market bonds at not exceeding 6% interest, recently voted—V. Ill, p. 2248—will be received by Louis Lesn, City Clerk. FAYETTEVILLE, Cumberland County, No. Caro.—BOND SALE.— Spitzer & Co., of Toledo offering $94,030 (100.03) and following 6% bonds—Y. Ill, p. i960: $80,000 street bonds. Due yearly on Dec. 1 as follows: $6,000 1922 to 1931, incl., and 84,000 1932 to 1936, incl. 14,000 funding bonds. Due yearly on Dec. 1 as follows: $1,000 1922 to On Nov. 24 Sidney interest were awarded the _ Date 1927 incl., and $2,000 1928 to 1931 incl. Dec. FERN 1 1920. SCHOOL Imperial County, Calif.—NO BIDS bonds— Dec. 6. FOLLETT INDEPENDENT SCHOOL DISTRICT (P. O. Follett), Lipscomb County, Tex.—BOND SALE.—This district sold $25,000 5% bonds to the State of Texas at par and interest, COUNTY (P. O. Hattiesburg), Miss .—DESCRIPTION 6% tax-free road and bridge bonds, recently awarded to Pope, Potter & Kauffman and Stix & Co., both of St. Louis.. —V. Ill, p. 1586—bear the following description. Denom. $1,000 Date Oct. 1 1920. Prin. and semi-ann. int. payable at St. Louis. Due yearly on Oct. 1 as follows: $2,000 1921 to 1925. incl., $4,000 1926 to 1935. incl., and $5,000 1936 to 1945, incl. The above bankers are now offering the said bonds to investors at price to yield 5.70% to 6%. FORREST The Franklin County, Ohio.—BOND SALE.—The Mer¬ of Billiards has purchased at par the $3,000 6% offered on Oct. 4—V. Ill, p. 1199. Date Aug. 1 Due $500 yearly on Aug. 1 from 1922 to 1927, incl. HILLIARDS, chants & Farmers Bank deficiency funding bonds 1920. HOCKING COUNTY (P. O. Logan), Ohio .—BOND OFFERING.— Clerk of Board of County Comm'rs, will receive bids until 30 for the following 6% Inter-County Highway impt. bonds: $73,600 Highway No. 155 Sec. "K" bonds. Date Dec. 1 1920. Due A. M. Ellinger, 2 p. m. Dec. $7^360 yearly on Mar. 1 from 1922 to 1930, incl,, and 7,360 Sept. 1 80,000 Highway No. 363 Sec. "N" bonds. Date Sept. 1 1920. Due I $8,000 yearly on Sept. 1 from 1921 to 1930, incl. ... 88,000 Highway No. 355 Sec. "P.-l" bonds. Date Sept. 1 1920. Due $8,800 yearly on Sept. 1 from 1921 to 1930, incl. _ 42,500 Highway No. 360 Sec. "G.-l" bonds. Date Sept. 1 1920. Due $4,250 yearly on Sept. 1 from 1921 to 1930, incl. ' Denom. to suit purchaser. Prin. and semi-ann. int. (M. & S.) payable at the County Treasury, where delivery to purchaser is to be made as soon as possible. Cert, checks for 10% of amount of bonds bid for, payable to County Treasurer, required. Purchaser to pay accrued interest. CONSOLIDATED SCHOOL DISTRICT NO 42 (P O. Hoople), Walsh and Pembina Counties, No. Da*c.—BOND SALE.— An issue of $2 STOCK BOARD OF KANSAS CITY THE EXCHANGE CHICAGO EXCHANGE No. 25 TRADE A SOUTHERN RAILWAY COMPANY. Broad St., New York, Dec. 21, 1920. quarterly dividend of ONE (1) PER CENT this day been declared upon the Preferred Stock of this Company from surplus earnings of the current fiscal year, payable January 15, 1921, to stockholders of record at 3:00 o'clock P. M., December 31, 1920. Checks in payment thereof will be mailed to stockholders at the addresses last furnished the has Stocks, Bonds, Cotton, Grain, Provisions Transfer Agent. , ATLANTIC 74 BROADWAY No. 13 South Street, Baltimore, Maryland, and upon proper receipt therefor being endorsed upon each bond. H. L. BORDEN, Vice-President. National Bank New York governments now offer investment opportunities, of varied maturities, to return CO. Safe Deposit 9800 PI ^HE external bonds of many foreign A RAILROAD presentation of such bonds at office of and Trust Company of Baltimore, upon ' LINE Interest of five per centum for fiscal year ending December 31st, 1920, will be paid upon the Income Bonds, dated December 12th, 1887, of Brunswick and Western Railroad Company, TELEPHONE RECTOR NEW YORK G. C. HAND, Secretary. COAST New high yields. York, Dec. 21, 1920. The Board of Directors has this day declared a quar¬ dividend of Three Dollars ($3.00) per share on the capital stock of this bank, payable January 3, 1921, to stockholders of terly W. A. Harriman & Co. INCORPORATED record at the close of busi¬ New York: 25 Broad Street ness December 1920. 24, PHILIP F. Boston: 60 Federal Street GRAY, Cashier. Syracuse: Onondaga Bank Bldg. BATTERY PARK NATIONAL BANK OF NEW YORK Sterling, Francs and Marks Edward E. Hall & Co. ARE WORTH Considerably More ThanExchange Rates Insurance Brokers 80 MAIDEN paymen t. hold notes, book account or other receivable payable in foreign currency communicate with us immediately. You will be able arrangement with claim is suitable* you to make us if It will NEW YORK LANE Tel. 4276 John your and Bonds, Automobile, policies properly Liability written? Advice given on policy contracts, fire protection and loss adjustments. Prompt coverage procured American Gas and preferred Electric Company stock dividend New York. December 13, 1920. The regular quarterly dividend of one and one(1H%) on the Issued and outstand¬ ing PREFERRED Capital Stock of American Gas & Electric Company has been declared for the quarter ending January 31, 1921, payable February 1, 1921, to stockholders of record on the books or the Company at the close of business January 15,1921. FRANK B. BALL. Treasurer. half per cent H. MERRY, Cashier. THE SEABOARD NATIONAL BANK THE CITY The Board OF NEW YORK. New York, December 16, 1920. of Directors has declared the regular quarterly dividend of three (3) per cent, payable on January 3, 1921, to stockholders of record on December 24, 1920. C. H. MARFIELD, Cashier. HANOVER NATIONAL BANK of the City of New York. New York, December 17, 1920. The Board of Directors have this day declared a dividend of EIGHT PER CENT, payable on and after January 3rd, 1921. The transfer books will remain closed from December 18th, 1920, Bttrfbestw THEISECUR1TIES COMPANY, Washington, D. C. A. THE cost DISTRICT NATIONAL BANK BUILDING, the close of business December wherever desired. an Foreign Claims Adjustment Syndicate at 1920. Fire, your nothing to find out. of record OF Are Holdup If you 1921, to Stockhold¬ ers 16th, If owed you on obligations con¬ tracted prior to July, 1919. This irrespective of date of December 16, 1920. The Board of Directors has this day declared semi-annual dividend of 3% on the Capital Stock of the Bank and an extra dividend of 3%, both payable January 3rd, a (Established 1866) 24 Broad Street. New York, December 14th, 1920. The Board of Directors of THE SECURITIES COMPANY have this day declared a semi-annual dividend of two and one-half per cent on the capital stock of the company, payable January 15th, 1921, to the Stockholders or record at the close of business on December 31st, 1920. E. G. WOODLING, Secretary. THE WESTERN UNION TELEGRAPH CO. December 14, 1920. DIVIDEND NO. 207. A quarterly dividend of ONE AND THREEQUARTERS PER CENT has been declared upon the Capital Stock of this Company, payable at the office of the Treasurer on and 15th day of January, 1921, record at the close of business after the until that date. IMPORTERS & TRADERS NATIONAL BANK OF NEW YORK. New York, Dec. 21, 1920. A dividend of Twelve Per Cent has to-day been declared by this bank, payable on the 3d day of January next to stockholders of record at the close of business December 21st, 1920. C. F. REGAN, Cashier. THE INDIANA & ILLINOIS COAL CORPORATION. New York, December 15th, 1920. The Board of Directors of Indiana <fc Illinois Corporation has this day declared a dividend of three and one-half per cent (3H %) on the Pre¬ ferred Stock of the Corporation, for the six months Coal to shareholders of period on the 20th day of December, 1920. The Transfer Books will remain open. G. K. HUNTINGTON, Treasurer. ' E. CABLE, JR.. Cashier. _ WM. ending December 31st, 1920, payable January 15th, 1921, to stockholders of record at the close of business on January 8th, 1921. Div¬ idend check will be mailed. THEODORE C. KELLER. Treasurer, Due. 25 1920.] THE CHRONICLE jffitancia! A 5]^% Federal Income Tax Exempt Bond At 100 and Interest $108,000 Robeson County, N. C. Road Bonds Principal and interest payable in New York, N. Y. Coupon bonds of $1,000 denomination FINANCIAL STATEMENT Assessed Valuation 1920. _____$71,385,618 Total Bonded Debt Rate Bonded of Debt 830,000 less than 114% of Assessed Population, 1920 Robeson County, Valuation 54,674 the 100 counties in North Carolina, ranks land values, population and assessed valuation. area, THIS ABLE ISSUE among IS PAYABLE FROM AN UNLIMITED PROPERTY WITHIN THE ~ TAX UPON ALL TAX¬ COUNTY. Legal opinion of Messrs. Storey, ' high in very Thorndyke, Palmer & Dodge " MATURING January 1, 1930, 1935 and 1940 R. M. GRANT & CO. 31 Nassau Street, Boston While we do not be to correct. ©toftieirtia NOTICE OF SKbtoenti* WESTINGHOUSE DIVIDEND. Electric Co. 1632 McCormick payable Jan. 3 1921 to stock¬ holders of record Dec. 21 Chicago, A Bldg., COMMON Stock of this Illinois. ter ending December January 31, 1921. 1920, At Stone & Webster, Inc., General Manager Puget Sound Power & Light Co. meeting of the Board of Directors of the Kansas & Gulf Company, held December 15, 1920, a quarterly divi¬ dend of 3% was declared on its out¬ standing capital stock, payable Janu¬ a 15, 1921, to stockholders of record 31, 1920. Transfer books will close December 31, 1920, and re¬ open January 17, 1921. i Both Dividends A December $0.75 quarterly dividend is payable Jan. 15, 1921, to Stock¬ holders of record Dec. 28, 1920. Stone & Webster, Inc., H. Boston, & CO., Mass. The quarterly dividend of 2% upon the com¬ mon stock of Winnsboro Mills has been declared payable January 3, 1921, at the office of the Company, to all holders of record at the close of business December 24, 1920. 233 GREENE January 3, 1921, quarterly dividend of fifty cents per share on outstanding capital stock, payable Febru¬ 1st, 1921, to stockholders or record at the close of business January 5th, 1921. Stock ary Henry C. Everett, Jr., Treasurer. December of Directors P. DIVIDEND of 16, 1920 the NO. per cent (l%%) Cumulative pany, First and a dividend of WARREN Y. and three-quarters one Per Centum of this Com¬ and one-quarter per cent (IM%) on the Five Per Centum Cumuative Second Preferred Stock of this Company, payable December 31, 1920, to stockholders of record December 16, 1920 H. B. CLEVELAND, business of on Treasurer. Board of Directors Corporation of the has this International declared day quarterly dividend of one and one-quarter (1>2%) per cent on the Preferred Stock of the Corporation, payable January 15, 1921, to stock¬ holders of record at the close of business Decem¬ ber 31, The 1920. transfer books will not be closed JOHN J. WATSON, Jr., Treasurer. BRAUN Jr., Treasurer. Treasurer. the three-quarters cent Second Preferred Stock of this Company have been declared for the quarter ending December 31st, 1920, payable on Janu¬ ary 3rd, 1921, to Stockholders of record at the close on Fuel and Company The regular quarterly dividend 17, 1920. of one and three -quarters per cent (1H%) on the Preferred Stock of this Company has been declared pay¬ able December 31st, 1920, to stockholders of record December 16th, 1920 J. A. McKENNA, Secretary. December HARRISBURG 16, 1920. AND LIGHT POWER COMPANY. BROTHERS COMPANY. PREFERRED DIVIDEND NO. 75. Dividends of one and one-half per cent on First Preferred Stock and one ana per Gas December Pittsburgh, Pa., Nov. 17, 1920. G. J. one on the Seven Preferred stock close the Checks will be mailed. H. PEPPER, Houston, Texas. ~ N. The Houston quarterly dividend of ONE AND THREE-FOURTHS PER CENT (1ZA %) on the 7% Cumulative Preferred Capital Stock, has this day been declared, payable Feb¬ ruary 1st, 1921, to stockholders of record Jan¬ uary 1st, 1921. Cheques will be mailed. Light and Railroad Company Elmira, at a 24 A Elmira Water, has declared a dividend of record Agricultural SANDS, Treasurer. DUQUESNE LIGHT CO. at of business December 24, 1920. WINNSBORO MILLS, Board of December 31, 1920. Managers, the office of the Transfer Agents, the New England Trust Co., Boston, Mass., to all holders of record at the close The Preferred Common the Agricultural Corporation. a Boston, Mass. The quarterly dividend of 1 % % upon the pre¬ ferred stock of Winnsboro Mills has been declared payable holders quarterly the on on New York, December 16, 1920. Broadway, New York, December 15, 1920 C. CO., & share 19 transfer books do not close. LOCKWOOD, share International The Board of Directors of the United Verde Extension Mining Company has this day declared Office of paid dividend of $i.50 per Stock and $2.00 per Stock; also an EXTRA dividend of $2.00 per share on the Common Stock, will be paid January 15, 1921, to Stock¬ regular VERDE EXTENSION the WINNSBORO MILLS, Henry C. Everett, Jr., Treasurer. quar¬ be 26th St. and 11th Ave., N. Y. O., Dec. 21 1920. A MINING COMPANY NO wil OTIS ELEVATOR COMPANY Managers, DIVIDEND 1920, are R. UNITED GREENE MOURER, President. Office of LOCKWOOD, L. General Manager Company for the 31, payable to Stockholders of record as of December 31, 1920. H. F. BAETZ, Treasurer. New York, December 23, 1920. ary Preferred Dividend No. 28 ELECTRIC & MANUFACTURING COMPANY. Quarterly Dividend of 2% ($1.00 per share) on the PREFERRED Stock of this Company will be paid January 15, 1921. f/M A Dividend of 2% ($1.00 per share) on the KANSAS & GULF COMPANY Preferred Dividend No. 29 A $3.00 semi-annual dividend is Chicago guarantee the above statements, we believe them ©ftubenb* Columbus New York St. Louis the of business on December 24, 1920. JOHN DEARBORN. Vice-President & Treasurer. Harrisburg, Pa. The Board of Directors has declared a regular quarterly dividend of one and one-half per cent (1H%) on the Preferred Stock of this Company, payable December 31st, 1920, to stockholders of record December 16, 1920. H. W. STONE, Treasurer. , For other dividends see page 2548. f ftmmUft THE CANADIAN BANK OF COMMERCE Statement of the result of the business of the Bank for the year ending 30th November, 1920 Balanc* at Credit of Profit and Loss Account brought forward from last Net Profits for the year ending 30th November, $1,427,735 40 year 3,306,243 97 after providing for all bad and doubtful debts...... $4,733,979 37 | This has been appropriated as follows: Dividends Nos. 132, 133, 134 and 135, at twelve per cent per annum Bonus of one per cent, payable 1st December Dominion and Provincial Written off Transferred Bank to Government taxes and tax Premises.. on $1,800,000 00 150,000 00 bank-note circulation..: —.. 350,000 00 — 500,000 00 ... 150,000 00 1,783,979 37 Fund Pension Balance carried forward * - . $4,733,979 37 GENERAL STATEMENT 30th NOVEMBER, 1920 LIABILITIES To the Public— \ Notes of the Bank in circulation.... $30,716,914 68 Deposits not bearing interest Deposits bearing interest, including interest accrued to date $108,813,028 52 285,065,493 05 . 393,878,521 57 792,301 53 — Balances due to other Banks in Canada Balances due to Banks and Banking Correspondents elsewhere than in Canada. 10,640,517 53 1,139,853 90 11,204,555 81 Bills Payable Acceptances under Letters of Credit $448,372,665 02 To the Shareholders— Dividends 3,980 12 Unpaid Dividend No. 130 and bonus, payable 1st December Capital Paid up ■.. 600,000 00 $15,000,000 00 _ Rest Account 15,000,000 00 Balance of Profits as per Profit and Loss Account 1,783,979 37 31,783,979 37 ■ '-V. ' $480,760,624^51 . ASSETS Gold and Silver Coin Current on hand $15,992,107 21 ... Gold deposited in Central Gold Reserves Dominion Notes 6,500,000 00 $22,492,107 21 on hand.. $35,388,710 25 ... Dominion Notes deposited in Central Gold Reserves 10,000,000 00 45,388,710 25 $67,880,817 46 „ Notes of other Banks Cheques on $2,482,865 00 other Banks 25,846,697 22 Balances due by other Banks in Canada Balances due by Banks and Banking Correspondents elsewhere than in Canada.. 100 00 11,290,555 29 ' 39,620,217 51 Dominion and Provincial Government Securities, not exceeding market value 13,101,656 80 British, Foreign and Colonial Public Securities and Canadian Municipal Securities, not exceeding market value | 20,737,620 72 ... Railway and other Bonds, Debentures and Stocks, not exceeding market value Call and Short Loans (not exceeding 30 days) in Canada on Bonds, Debentures and Stocks Call and Short Loans (not exceeding 30 days) elsewhere than in Canada Deposit with the Minister of Finance for the purposes 6,059,204 45 21,434,844 02 34,274,934 06 908,245 56 of the Circulation Fund $204,017,440 58 Other Current Loans and Discounts in Canada (less rebate of interest) *___ Other Current Loans and Discounts elsewhere than in Canada (less rebate of interest) Liabilities of Customers under Letters of Credit, as per contra 231,114,772 74 .... 26,863,226 72 11,204,555 81 147,916 91 ... ... Overdue Debts (estimated loss provided for) Real Estate other than Bank Premises.. Mortgages on Real Estate sold by the Bank 514,901 50 .... 190,501 63 ... Bank Premises at cost, less amounts written off Other Assets not included in the 6,617,095 06 90,213 56 foregoing $480,760,624 51 B. E. WALKER JOHN AIRD President Report of the Auditors : / ^ General Manager to the Shareholders of The Canadian Bank of Commerce In accordance with the provisions of sub-sections 19 and 20 of section 56 of the Bank Act, 1913, we report as follows: We have audited the above Balance Sheet and compared it with the books and vouchers at Head Office and with the certified returns from the branches. quired, and the powers of the opinion of the Bank. are We have obtained all the information that the transactions of the Bank which have and come that we have re¬ notice have been within explanations under our We hare checked the cash, and verified the securities representing the investments of the Bank, at its chief office and principal branches at a date other than that of the verification at the chief office on the 30th November, 1920, and found that they were in agreemeut with the entries in the books of the Bank relating thereto. a true and correct view of thestateof the explanations given to us, and as shown by the In our opinion the Balance Sheet is properly drawn up so as to exhibit affairs of the Bank according to the best of our information and the books of the Bank. T. HARRY WEBB, . _ C. A. . _ _ 1 i Auditors, JAMES , MARWICK, C. A. of Marwick, Mitchell & Co . Due. 251920.] THE TTOl CHRONICLE Jftiraittial New Issue $10,000,000 Pacific Gas & Electric Company First and Refunding Mortgage Gold Bonds Twenty-Year 7% Series "A" Dated December 1, 1920 Due December 1, 1940 Interest payable June 1 and December 1 in New York or San Francisco without deduction of the Normal Federal Income Tax of 2%. Coupon Bonds in denominations of $500 and $1,000 each, registerable and interchangeable Redeemable at the with fully registered Bonds in denominations option of the Company 110 and accrued interest on or on any of $1,000, to principal only, interest payment date upon sixty days' prior notice at before December 1, 1930. and at 105 and accrued interest thereafter. NATIONAL CITY BANK OF NEW YORK THE MERCANTILE as $5,000 and $10,000 each. TRUST COMPANY OF \_ FRANCISCO/Trustees SAN Application has been made to the Superintendent of Banks to certify these Bonds as legal investment for savings banks in California. and Electric Company is recognized as one of the largest public service corporations in the United States. Its properties extend into thirty-six counties in Cali¬ fornia and serve an estimated population of 1,850,000, including the cities of San Francisco, Pacific Coast, which the Company controls through ownership of the Mt. Shasta Power Corporation. This project has an ultimate capacity of more than 420,000 horsepower, of which 126,500 is now in process of development. Hp HE Pacific Gas -*■ These Bonds, in the opinion of counsel, will a direct first mortgage on the entire Oakland and Sacramento. For more of the constitute than forty years the electric business properties of the Mt. Shasta Power Corporation, a direct mortgage on the entire properties of the Pacific Gas and Electric Company subject to prior lien of underlying mortgages. and its predecessors has been in continuous and successful operation and now contributes more than 60% of the gross earnings, which for the year endea November 30, 1920, were over $34,500,000; the gas business has been continuously and successfully conducted for more than sixty-five years. The Company or Net earnings in each of the past four years have than double all interest charges. For the year ended November 30,1920, net earnings, which only partially reflect increased gas and electric rates, were more than 1.95 times annual interest charges including this new $10,000,000 7% issue. been twenty-four hydro¬ plants having an aggregate capacity of 428,000 horse¬ power, and twenty gas manufacturing plants with a total daily capacity of 71,600,000 cubic feet. Company operates electric stations and four steam turbine The mortgage, in addition to providing strong sinking and maintenance funds, also provides that additional first and refunding mortgage bonds may only be issued under conservative The be proceeds from the present financing will largely devoted to the development of one of promising hydro-electric projects on the restrictions. the most We recommend these Bonds Price 99 and accrued interest, Bonds are offered if, as for investment yielding about 7.10% and when issued and received by us, subject to all necessary legal proceedings as to and Circular authorization approval. giving details of this issue will be sent upon request. E. H. Rollins & Sons more The National City Company The above information is derived from official sources or those which we regard as reliable. We do not guarantee but believe it to be correct. ;v XXIV THE CHRONICLE [Vol. 111. JSatrfe Statements The! Royal Bank of Canada Fifty-first Annual Statement NOVEMBER 30, 1920 LIABILITIES Capital Paid Up.—-- - Reserve Fund : . ...— Undivided Profits Dividend No. 133, payable December 1, 1920 Bonus of 2%, payable December 15, 1920 Notes in Circulation— Deposits _ _ ..... — . — ———— £ .... Due to other Banks Due to Dominion Government ....... ... Bills payable (Acceptances by London Branch) Acceptances under Letters of Credit $20,134,010.00 20,134,010.00 558,035.57 585,979.48 402,680.20 41,672,973.74 455,017,387.02 14,965,810.47 19,972,801.38 3,997.678.28 17,228,647.29 $594,670,013.43 ASSETS Cash on Hand and in Banks—...... $147,509,386.19 23,500,000.00 ,, ... Deposit in the Central Gold Reserves Government and Municipal Securities Railway and Other Bonds, Debentures and Stocks.. j. 34,208,299.70 16,117,459.49 12,899,573.85 44,962,994.23 Call Loans in Canada Call Loans elsewhere than in Canada $279,197,713.46^ Loans and Discounts Liabilities of Customers under Letters of Credit Bank Premises as ..$286,842,000.84 17,228,647.29 9,498,425.46 966,349.43 860,000.00 per contra. Real Estate other than Bank Premises Deposit with Dominion Government for Security of Note Circulation. Other Assets not included in the foregoing 76,876.95 $594,670,013.43 PROFIT AND LOSS ACCOUNT Balance of Profit and Loss Account, 29th November, 1919 $1,096,418.74 Profits for the year, after deducting charges of management and all other expenses, accrued interest on deposits, full provision for all bad and doubtful debts and rebate of interest on unmatured bills 4,253,649.24 $5,350,067.98 APPROPRIATED AS FOLLOWS: Dividends Nos. 130 131,132 and 133 at 12 per cent, per Bonus of 2 per cent, to Shareholders Transf<rred to Officers' Pension Fund annum , .... ...... ... Written off Bank Premises Account. War Tax on Bank Note Circulation Transferred to Reserve Fund $2,153,159.11 402,680.20 100,000.00 400,000.00 180,295.47 1,567,005.00 .... M Balance of Profit and Loss carried forward. 546,928.20 $5,350,067.98 RESERVE FUND Balance at Credit, 29th November, 1919 Premium on New Capital Stock $17,000,000.00 1,567,005,00 1,567,005.00 Transferred from Profit and Loss Account.. Balance at Credit, 30th H. S. November, 1920 HOLT,H $20,134,010.00 EDSON President. Montreal, 18th December, 1920. L. PEASE, Managing Director. C. E. NEILL, General Manager. AUDITORS' CERTIFICATE We Report to the Shareholders of the Royal Bank of Canada: That in our opinion the transactions of the Bank w hich have the Bank. _ That come under our notice have been within the powers of have checked the cash and verified the securities of the Bank at the Chief Office at 30th November, 1920, well as at another time, as required by Section 56 of the Bank Act and that we found they agreed with the entries in the books mregard thereto. We also during the year checked the cash and verified the securities at the principal branches. That the above Balance Sheet has been compared by us with the books at the Chief Office and with the certified returns from the Branches and in our opinion is properly drawn up so as to exhibit a true and correct view of the state of the Bank s affairs according to the best of our information and the explanation given to us and as shown by the books of the Bank. we as That we have obtained all the information and explanations reouired by us. JAMES MARWIOK, C.A., S. x , F. T. Agency; Corner William Walker, I MITCHELL, C.A., of Mar wick, Mitchell and Co. JAMES G. ROSS, C.A., of P. S. Ross & Sons, Montreal, Canada, I8th December, 1920. New York ROGER ' ^ J. A. Beatson, E. B. & Cedar Streets Mclnerney, Agents Auditors, Dec. m CHRONICLE THE 251920.] jffnanrial NEW£ISSUE $4,000,000 General Asphalt 8% Ten Year Sinking Fund Dated December 1, Convertible Gold Bonds Due 1920 1931 December 1, December Redeemable at v Principal and interest payable at the office of Bankers Trust Co., New York City. Interest payable June 1 and Coupon bonds in $1,000 and $100 denominations, with privilege of registration of principal. the option of the Company on any interest date on 30 days' published notice in amounts of $500,000 or multiples thereof, at 105 on or before December 1, 1926; at 104 on or before December 1, 1927; at 103 on or before December 1, 1928; at 102 on or before December 1, 1929, and at 101 thereafter prior to maturity, with accrued interest in each case; callable for Sinking Fund purposes at the same dates and prices. , Bankers Trust Company, The bonds Company, are The Company agrees resident in 60 days New York, Trustee time after January 1, 1923, into common stock of tl the option of the Company or for Sinking Fund purposes, coi date. convertible at the option of the holder at any for par. If bonds are called, either at be made up to and including redemption par version may - to pay the normal Federal Income Tax not to exceed 2% per annum, and to reimburse holde^ assessed in that State, and paid by them, upon request to the Trustee witl '\- ■ Pennsylvania for the four mills tax after payment. From his letter to us dated December 17, Mr. Arthur W. Sewall, President of the Company, summarizes as Asphalt Company, through its subsidiary companies, asphalt and oil, and the manufacture of a wide range of The General BUSINESS: and sale of fied production gives it a dependable earning power industries which are already established and capable follows: is engaged in the products their products. Its diveri throughout the year and has developed alli< of great future growth. includes valuable rights to deposits o asphalt in Trinidad and Venezuela in the State of Utah; also a well equipped railroad of 68 miles, own< and operated in connection with the Utah property. The refineries and manufacturing plan| are being expanded to care for the increasingly diversified character of the Company's busines The oil interests, including association with the Royal Dutch-Shell Group in the ownership petroleum rights on 312,500 acres of land in Venezuela, are considered a valuable asset. The property PROPERTY: under United States patents BOND issue of bonds is a direct obligation of the Company, which itself has No mortgage, by either the Company or its controlled subsidiaries, upon the respective real estate, plants or physical properties will be created while any of this issue is or standing, but property may be acquired subject to existing mortgage or purchase money moi gage not to exceed 75% of fair value of property acquired. It is intended to apply the of this issue to the payment of notes payable, to provide working capital and toward the acquis! tion and retirement of $599,945 New Trinidad Lake Asphalt 6% Debentures, which constitul the only mortgage indebtedness of any of the subsidiary companies. The only other funded of the Company is $1,415,000 unsecured 6% Debentures, due April 1st, 1925. This $4,000,000 ISSUE: mortgage debt. proeeej def Consolidated net assets, after completion of this financing, are in excess of $37,000,000, approximately six times the amount of outstanding obligations, including this issue. ASSETS: ending December 31, 1919, average For five years EARNINGS: interest the Company exclusive which sinl earnings available to meet sinking fund charges, were 23^ times the amount which will be required to pay total fixed charges for interest and sinking fund upon completion of this financing, the sinking fund on the outstanding 6% debentures of General Asphalt Company fund is 10% of annual net earnings. Convertible at option of CONVERTIBILITY: par holder after January 1, 1923, into common stock of the Companj par. of $50CM December 1, 19^ the premium decreasing 1% annually to 101 in 1930 prior to maturity, with accrued interest each $50,000 semi-annual cumulative sinking fund payment, on April 15 and October of each year, to purchase bonds at less than redemption price, or if not then available, for pi REDEMPTION: or AND SINKING for FUND: Any or all bonds callable on 30 days' notice on any interest date, in amounts multiples thereof (except for Sinking Fund purposes) at 105 on or before case. ment of bonds date at current on not less than 20 days' notice at next succeeding outstanding preferred and common stocks of including this issue of bonds, is over $13,500,000 as The market value of the EQUITY: by lot redemption price. to be called follow the funded debt, PRICE, 98V2 and interest, the Company whij of December 16. yielding about 8.20% DREXEL & CO. Chestnut and Fifth Streets PHILADELPHIA The information and statistics contained in the above advertisement from sources that we deem reliable, and while not guaranteed are / mter< have been obtained accepted by us as correct. [Vol. 111. CHRONICLE THE XXVI jftoantfal $10,000,000 Kansas City Power and Light Company First and Refunding Mortgage Twenty-Year 8% Dated December 1, • i.v; . Gold Bonds, Series A Due December 1, 1940 1920 • .. ' •; -.7,-v.;;-!;1' "v." •;;... .. •' , Principal and Interest payable in New York or Chicago. Interest payable semi-annually June 1 and December 1. Coupon bonds in interchangeable denominations of $1,000. $500 and $100, registerable as to principal, and fully registered bonds in denominations of $1,000, $5,000, $10,000 and $25,000. Coupon and registered bonds are interchangeable. Redeemable in whole or in part on any interest date on sixty days' notice on or before De¬ cember 1, 1925, at 107K and accrued interest; thereafter and on or before December 1, 1930. at 105 and accrued interest; thereafter and on or before December 1, 1935, at 102M and accrued interest, and thereafter until maturity at Interest AND 1 payable without deduction of normal Federal Income Tax deductible CONTINENTAL , and accrued interest. 101 COMMERCIAL the at TRUST not source, AND SAVINGS in of 2% excess CHICAGO, CORPORATE TRUSTEE. BANK, The issuance of these Bonds has been authorized by Missouri Commission of and the Kansas Court of the Public Service Industrial Relations For detailed President information regarding these Bonds, attention is directed to a letter of Mr. Joseph F. Porter, of the Company, copies of which will be furnished upon request, from which the following is summarized: The Kansas City Power and Light Company serves with electric light and the City of portion of Kan- power Kansas City, Missouri, and a City, Kansas, the total population served being approximately 450,000. sas months ended October 31, were $5,762,844.48 and net earnings before depreciation $1,975,885.68. The annual interest requirements on the total the For 1920, gross mortgage twelve earnings indebtedness outstanding in the hands of the public, These Bonds will be secured by a direct first the recently completed North- mortgage lien on Power Plant, east certain substations, trans mission and distribution lines, and other • prop- including this issue and bonds held alive in sink ng fund, amount to $1,068,038, of which interest $600,000 is attributable to construction expenditures from which the Company has not yet received full the aggregate value of these properties being approximately $10,500,000. On the re¬ maining property of the Company these Bonds will be secured by a direct mortgage lien, sub- benefits, ject only to underlying First and Second Mort- months ending December 31, 1920, are estimated at $2,150,000, or over twice the annual erty; outstanding, and Will share to the extent of 60% in the first lien on such property through pledge of $4,617,000 par value of Kansas City Light & Power Company First Mortgage Bonds. gage Bonds now The total value of the Company's properties, as recognized by the Public Service Commission of Missouri for rate making purposes, is in ex- of $22,400,000. There will be $14,755,500 (including underlying issues) presently outstanding in the hands of the public. cess bonds Based upon results for the first ten months, net earnings before depreciation for the twelve interest requirements shown above. new plant, the above estimate of net earnings for the year 1920 would be increased from its to approximately $2 750,000. It is expected that in 1921 practically all current will be generated at the new power plant, The franchise The Company's new Northeast Power Plant is one of the most modern and efficient steam generating stations in the country and is so designed that its present installed capacity of 60,000 k. w. may be increased to an ultimate ca¬ pacity of 240,000 k. w. The factory. situation is eminently satis- Company's electric are, • The Trust Deed will -l provide for an annual Maintenance and Depreciation Fund amounting to 12^% if gross earnings, as outlined in the President's letter. power light and franchises, both in Missouri and Kansas, with minor exceptions, perpetual. heating franchise runs until 1935. Kansas City, Missouri, has had a Steam- remarkable growth during the past forty years and is still rapidly increasing in size and importance. It is second among the country's live-stock markets and packing centres, and the third largest grain market. Price 100 and Interest, When, as and if issued and received for delivery on or about January 3. During this period the Company will have produced, at its new Northeast Power Plant, only about 60% of its power requirements. Had the Com¬ pany secured its entire output during the year Yielding 8% by us and subject to approval of counsel. It is expected that Bonds in temporary form will be ready Legal details pertaining to this issue will be passed upon by Messrs. Rushmore, Bisbee & Stern, of Messrs. Mayer, Meyer, Austrian and Piatt, of Chicago. New York and by Continental and Commercial Trust and Savings Bank Chicago Guaranty Company of New York Halsey, Stuart & Co., Inc. 1 We do not guarantee the statements and figures contained herein, but they Chicago-New York are taken from sources which we believe to be reliable. Dec. the 251920.] xxvn chronicle Jffnancfal $30,000,000 STANDARD OIL COMPANY OF NEW YORK 7% Serial Gold Debentures To be dated January 2, Interest payable January 2 and July 2 1921 Total authorized issue $30,000,000, due in seven annual serial installments, as follows: $4,000,000 due January 2, 1928 4,000,000 " " 2, 1929 4,000,000 " " 2, 1930 $6,000,000 due January 2, 1931 $4,000,000 due January 2, 1925 4,000,000 " " 2, 1926 4,000,000 " " 2, 1927 Coupon Debentures in $100 with privilege of denominations of $1,000, $500 and registration as to principal 1925, at 105 and accrued interest; if redemption, the longest outstanding maturities are to be called first. Redeemable in whole or in part on any interest date on and after January 2, less than the entire issue should be called for Interest payable at the office of The Equitable Trust Company of New York or Blair & Co., Inc., without deduction for any Income Tax not exceeding 2% in any year which the Company or the Trustee may be required to pay thereon or retain therefrom under any present or future law of the United States of America. THE Mr. H. C. Federal EQUITABLE TRUST COMPANY OF NEW YORK, TRUSTEE Folger, President of the Company, writes under date of December 15, 1920, as follows: These Debentures will be the direct obligation of the Standard Oil Company ofj-New "SECURITY: York and will constitute its sole funded debt. NET EARNINGS of the Company compare as ■■■■•'/ ; follows: Before Federal Taxes Year After Federal Taxes $37,401,764 $36,638,495 1917 39,376,043 1918 44,157,080 30,000,672 28,642,387 43,165,109 1916 1919 Net earnings . . . . . . ...... 58,330,176 for 1920 before Federal taxes are estimated at $60,000,000. before taxes for the four years ended December 31, 1919, averaged 20 times the the new Debentures and for 1919 were nearly 28 times such annual interest. Net earnings interest on annual The balance sheet as of June 30th, 1920, shows total net assets of $246,196,981 and net quick assets of $133,768,112. Adding the proceeds of the new Debentures, the total net assets exceed nine times these Debentures and the net quick assets alone on this basis exceed five times ASSETS : these Debentures. nothing for good will and does not reflect the very substantial increase Company's physical and other properties accruing over a period of years. The balance sheet includes in the value of the The Company has outstanding $75,000,000 capital stock on which dividends of 16% per being paid. At present quotations this stock represents an equity of about $250,000,000 ranking junior to these $30,000,000 Debentures. EQUITY : annum are These Debentures are to be issued under an indenture Equitable Trust Company of New York, as Trustee, providing, in substance, among other things, that the Company will not create any mortgage oh or pledge of its properties unless these Debentures shall share equally and ratably in the lien of such mortgage or pledge, but this shall not apply to purchase money mortgages or pledges of personal property to secure temporary loans in the usual course of business, and shall not restrict the acquisition of additional property subject to lien RESTRICTIONS AGAINST MORTGAGE : with The or mortgage. CURRENT DEVELOPMENTS : The Company is engaged in adding to its refinery capacity, marine equipment, etc., the earning capacity of which expenditures, and of the proceeds of this issue, will be reflected in the future operation of the Company. Its capital requirements have been supplied almost entirely from earnings. In the five years ended December 31st, 1919, approximately $115,000,000 from surplus earnings have been reinvested in the business". legal proceedings in connection with the issue, are being passed upon by Messrs. Hsrnblswer, Garrison and Messrs. Murray, Prentice & Howland, New York. The Pending receipt by us of Temporary Debentures, interim receipts may be delivered. of counsel, "when, as and if issued and received Circular Price Co. Blair 100 All offerings are subject to approval by us". Request and accrued interest The Equitable Trust Co. OIF NEW YORK incorporated Wm. The statements on Miller <k A. Read <& Co. presented above while not guaranteed, have been obtained from sources All the above Debentures which we believe to be reliable. having been sold, this advertisement appears as a matter of record only. CHRONICLE THE jTfnandal BUY RESULTS By Buying the Chicago Tribune line of sell goods: make NOW is the time for advertisers to buy results. Make every dollar to beat every expended build sales. stitutional" and nated to copy "Prestige," "in¬ "general" publicity must be subordi¬ direct action advertising if 1921 1920 records. business is Circulation must be cold-blooded basis times. ready to have bought on of price and quick results. The Chicago Tribune welcomes the test of these strenuous It is in the balance against advertiser weigh it every other available medium for any creating sales. More and advertisers more apportioning are large blocks of their national appropriations for commanding campaigns in The Chicago Tribune, because: 1. : The market dominated by - . The Chicago Tribune (Illinois, Indiana, Iowa, Michigan and Wisconsin) with twice the population Dominion of Canada is able to production of but the any consume very the of the entire largest manu¬ facturers. 2. Prosperity of this market is indicated by the enormous and by crops a decrease in business failures notwithstanding the contrary throughout the rest of the country. 3. Overwhelming and 800,000 trend Circulation—450,000 Sunday—reaching best Daily buying classes in the five States. 4. Economy—of advertising appropriations be¬ cause of low cost of space per and of line per thousand— merchandising appropriation because of a compact territory plus Chicago Tribune Mer¬ chandising Service. \ The and Advertising Managers' Council of the Motor Accessory Manufacturers' Association re¬ cently discussed Turn Our mediums the question 4'How Can We Prestige Advertising Into Cash." were considered but the- answer All was NEWSPAPERS. The Chicago Tribune paper, but it is a is only not a great sectional medium unique sales-building powers in a market news¬ with that constitutes one-fifth of the United States. 0fye (Mjxcaqcr Qaxbxxxxe $jTHE WORLD'S Tribune Bldg., Chicago. CREATEST NEWSDAPFP 512 Fifth Ave., New York. Haas Bldg.. Los Angeles. Inside FRASER
https://fraser.stlouisfed.org/title/commercial-financial-chronicle-1339/december-18-1920-552831/fulltext
Coaching for physicians | The College of Family Physicians of Canada Coaching for physicians Building more resilient doctors With the unprecedented rate of change in health care, it has become even more difficult for family physicians to balance their practices and personal lives Studies are beginning to show high levels of “burnout” among family physicians Lee et al found that 69.2% of family doctors participating in their study were moderately or highly stressed and discovered a correlation between stress and burnout and a desire to leave practice.1Given the human resource implications, attention is increasingly being paid to the importance of physician resilience. In the May issue of Canadian Family Physician,the study by Jensen et al identified 4 elements associated with successful adaptation: attitudes and perspectives, balance and prioritization, practice management, and supportive relations.2The authors argued that resilience is not only a product of inherent personality traits, but can also be improved by way of learned behaviour. This raises the following question: How can an already harried physician move toward more adaptive behaviour? Good intentions alone will not pave the way. Over the past decade or more, business and finance executives have employed life or business coaches to improve their clarity of purpose, focus, creativity, productivity, and work-life balance, among other goals. Physicians and executives have much in common: they strive for excellence in their respective fields, experience time constraints, bear heavy workloads, and perform under scrutiny (from patients or clients, colleagues, and authorities). Add to this the fact that family physicians feel undervalued and unsupported in the current health care climate and it is no wonder that they often feel tense, tired, indecisive, apathetic and even, at times, trapped. Most of these doctors do not suffer from formal psychiatric diagnoses and do not require psychiatric or psychological support. Nevertheless, it can be difficult for them to objectively reflect on their lives and summon adequate discipline and motivation to make and maintain critical changes. This is where life coaching can be helpful. What, how, and why? Life coaching is a nondirective process that draws upon techniques from positive psychology and both cognitive-behavioural and solution-focused therapies to help people thrive personally and professionally, by increasing their self-awareness, building on their strengths, and applying their insights creatively so they can move forward. Unlike counseling, it is for people free of meaningful psychopathology and is concerned with growth rather than healing. Carol Kauffman, PhD, Assistant Clinical Professor and Director of the Coaching and Positive Psychology Initiative at Harvard Medical School, strongly states the following: Positive psychology theory and research will provide the scientific legs upon which the field of coaching can firmly stand …. There are psychometrically robust measures to assess strengths and empirically testable positive interventions that have been found to increase happiness, productivity and life satisfaction.3 For example, in one study, Seligman et al confirmed that 3 of 5 purported happiness interventions resulted in sustained improvement on measures of happiness and depressive symptoms.4 Another study showed that third-year medical students with positively primed emotions arrived at an accurate diagnosis more efficiently and with greater curiosity and less disorganization than control subjects.5Fredrickson and Losada concluded that “positivity can transform individuals for the better, making them healthier, more socially integrated, knowledgeable, effective and resilient[emphasis added].”6 A life coach will partner with a physician-client to take a critical look at his or her life and practice, thereby identifying counterproductive attitudes and behaviour as well as existing personal strengths that might offset them. These insights are then applied to develop a more adaptive perspective, a wider behavioural repertoire, efficient practice- management strategies, tighter personal boundaries, and improved interpersonal skills, while respecting the individual doctor’s needs and priorities. Life coaching can give family doctors a rare opportunity to establish parameters for evaluating their own success, which can be difficult to recognize when treating chronic illnesses with little time to reflect. The coach will encourage the clients and hold them accountable if they procrastinate or become distracted. Simply put, the coach is a catalyst for change. We encourage readers to share some of their practice experience: the neat little tricks that solve difficult clinical situations.Praxisarticles can be submitted on-line athttp://mc.manuscriptcentral.com/cfpor through the CFPwebsitewww.cfp.caunder “Authors.” Competing interests Dr Askinis a practising life coach. Copyright© the College of Family Physicians of Canada References LeeFJStewartMBrownJBStress, burnout and strategies for reducing them. What’s the situation among Canadian family physicians?Can Fam Physician200854234-5.e15 JensenPMTrollope-KumarKWatersHEversonJBuilding physician resilienceCan Fam Physician2008547229 KauffmanCStoberDGrantAPositive psychology: the science at the heart of coachingThe evidence based coaching handbookHoboken, NJJohn Wiley & Sons, Inc; 200621954 SeligmanMSteenTAParkNPetersonCPositive psychology process: empirical validation of interventionsAm Psychol200560541021 IsenAMRosenzweigASYoungMJThe influence of positive affect on clinical problem solvingMed Decis Making19911132217 FredricksonBLLosadaMFPositive affect and the complex dynamics of human flourishingAm Psychol200560767886
https://www.cfp.ca/node/19733.full.print
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Marine strata include three calcareous, glauconitic, fossiliferous marine units: Wharekuri Greensand (Lower Whaingaroan); Kokoamu Greensand/Kekenodon Beds (Upper WhaingaroanDuntroonian); and Otekaike Limestone (Duntroonian-?Waitakian). The Kokoamu Greensand is separated from Wharekuri Greensand by a bored surface, Fordyce and Watson (1998) interpreted this as the mid-Oligocene unconformity, which Fulthorpe et al. (1996) correlated with a global eustatic sea level fall. The Wharekuri Creek marine rocks contain members of the stratigraphically important pectinid bivalve lineage Janupecten-Lentipecten. Here,Janupecten show progressive reduction in sculpture leading to evolution of smooth-shelled Lentipecten. The evolution to smooth valves indicates enhanced level-swimming ability. Deposition of the coarsening upward Southburn Sand {Early? Miocene), following the Otekaike Limestone, represents a transition to a near shore environment. The Waitangi Coal Measures (Middle?-Late? Miocene), which may overlie the Southburn Sand unconformably, are tentatively placed within the Manuherikia Group of Central Otago, because they also represent a deltaiclacustrine succession of peat, laminated muds, clays, and sands. Following accumulation of the coal measures at Wharekuri Creek, the Kurow Gravels were deposited as longitudinal bars in a braided river system. The name Kurow Group is not used here, because the name Kurow Gravels takes priority. Late Cenozoic faulting, presumably associated with development of the Southern Alps, has deformed the sedimentary sequence at Wharekuri Creek. The Kokoamu Greensand is juxtaposed against the Southburn Sand by the Waitangi Fault and the Southburn Sand is faulted against the Waitangi Coal Measures. The Wharekuri Fault has uplifted semi-schist basement of the Haast Schist Group against the Waitangi Coal Measures and the Kurow Gravels. Gravels and angular debris from the St Marys Range cover much of the area so that it is not possible to see crosscutting relationships which may indicate the sequence of faulting. </text > <text > ... </text > </elementText > <elementText elementTextId =" 34332 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 55 " > ... </element > <element elementId =" 59 " > <name > Department </name > <description > The department where the student is studying primarily. </description > <description > ... </description > <elementTextContainer > <elementText elementTextId =" 34333 " > <text > Geology </text > </elementText > <elementText elementTextId =" 34333 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 59 " > ... </element > <element elementId =" 61 " > <name > Named locality </name > <description > Named locality describing the field area location. </description > <elementTextContainer > <elementText elementTextId =" 34334 " > <text > Wharekuri Creek </text > </elementText > <elementText elementTextId =" 34334 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 61 " > ... </element > <element elementId =" 60 " > <name > Thesis description </name > <description > Number of pages, maps, CDs, etc. </description > <elementTextContainer > <elementText elementTextId =" 34336 " > <text > 131 p. : ill. (some col., one folded), maps ; 30 cm. </text > <text > ... </text > </elementText > <elementText elementTextId =" 34336 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 60 " > ... </element > </elementContainer > <elementContainer > ... </elementContainer > </itemType > <itemType itemTypeId =" 18 " > ... </itemType > <elementSetContainer > <elementSet elementSetId =" 1 " > <name > Dublin Core </name > <description > The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. </description > <description > ... </description > <elementContainer > <element elementId =" 43 " > <name > Identifier </name > <description > An unambiguous reference to the resource within a given context </description > <description > ... </description > <elementTextContainer > <elementText elementTextId =" 34324 " > <text > 1998McDermid </text > </elementText > <elementText elementTextId =" 34324 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 43 " > ... </element > <element elementId =" 39 " > <name > Creator </name > <description > An entity primarily responsible for making the resource </description > <description > ... </description > <elementTextContainer > <elementText elementTextId =" 34327 " > <text > McDermid, Isabella (Isabella Rose Cross), 1975- </text > </elementText > <elementText elementTextId =" 34327 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 39 " > ... </element > <element elementId =" 40 " > <name > Date </name > <description > A point or period of time associated with an event in the lifecycle of the resource </description > <description > ... </description > <elementTextContainer > <elementText elementTextId =" 34328 " > <text > 1998 </text > </elementText > <elementText elementTextId =" 34328 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 40 " > ... </element > <element elementId =" 50 " > <name > Title </name > <description > A name given to the resource </description > <elementTextContainer > <elementText elementTextId =" 34330 " > <text > Geology of Wharekuri Creek </text > </elementText > <elementText elementTextId =" 34330 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 50 " > ... </element > <element elementId =" 49 " > <name > Subject </name > <description > The topic of the resource </description > <elementTextContainer > <elementText elementTextId =" 34335 " > <text > Lithostratigraphy </text > </elementText > <elementText elementTextId =" 34335 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 49 " > ... </element > </elementContainer > <elementContainer > ... </elementContainer > </elementSet > <elementSet elementSetId =" 1 " > ... </elementSet > </elementSetContainer > <elementSetContainer > ... </elementSetContainer > <tagContainer > <tag tagId =" 894 " > <name > Duntroonian </name > </tag > <tag tagId =" 894 " > ... </tag > <tag tagId =" 730 " > <name > Kokoamu Greensand </name > </tag > <tag tagId =" 730 " > ... </tag > <tag tagId =" 430 " > <name > Manuherikia Group </name > </tag > <tag tagId =" 430 " > ... </tag > <tag tagId =" 494 " > <name > Otago </name > </tag > <tag tagId =" 494 " > ... </tag > <tag tagId =" 682 " > <name > Otekaike Limestone </name > </tag > <tag tagId =" 682 " > ... </tag > <tag tagId =" 697 " > <name > Waitakian </name > </tag > <tag tagId =" 697 " > ... </tag > <tag tagId =" 893 " > <name > Whaingaroan </name > </tag > <tag tagId =" 893 " > ... </tag > <tag tagId =" 892 " > <name > Wharekuri Greensand </name > </tag > <tag tagId =" 892 " > ... </tag > </tagContainer > <tagContainer > ... </tagContainer > </item > <item itemId =" 343 " public =" 1 " featured =" 0 " > ... </item > <item itemId =" 198 " public =" 1 " featured =" 0 " > <fileContainer > <file fileId =" 193 " > <src > http://theses.otagogeology.org.nz/files/original/d570fc813f32a62ca5ec35516fec57c1.pdf </src > <src > ... </src > <authentication > 720b7d2203e519dd8a5476d8b144d620 </authentication > </file > <file fileId =" 193 " > ... </file > </fileContainer > <fileContainer > ... </fileContainer > <collection collectionId =" 1 " > <elementSetContainer > <elementSet elementSetId =" 1 " > <name > Dublin Core </name > <description > The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. </description > <description > ... </description > <elementContainer > <element elementId =" 50 " > <name > Title </name > <description > A name given to the resource </description > <elementTextContainer > <elementText elementTextId =" 1 " > <text > Geology theses </text > </elementText > <elementText elementTextId =" 1 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 50 " > ... </element > </elementContainer > <elementContainer > ... </elementContainer > </elementSet > <elementSet elementSetId =" 1 " > ... </elementSet > </elementSetContainer > <elementSetContainer > ... </elementSetContainer > </collection > <collection collectionId =" 1 " > ... </collection > <itemType itemTypeId =" 18 " > <name > OU Geology thesis </name > <description > Thesis or dissertation completed by University of Otago Geology students </description > <description > ... </description > <elementContainer > <element elementId =" 62 " > <name > Location WKT (WGS84) </name > <description > The location stored in WKT (WGS84) format </description > <elementTextContainer > <elementText elementTextId =" 32193 " > <text > POLYGON ((169.143283041481027 -44.712047221325612,169.327674683346572 -44.767404350983362,169.373324006967522 -44.799233214520761,169.378154611456353 -44.842259234582386,169.335911839561476 -44.87485054542735,169.27143624267211 -44.931710037041356,169.249102280689442 -44.950270040056132,169.252492738990071 -45.052559060038853,169.427389308816146 -45.246208700507431,169.593183901017284 -45.088252298371934,169.809356793282632 -44.852158055533671,169.874927373418956 -44.809909460353751,170.148136716390155 -45.091826788547969,170.281961131052043 -45.120839118817152,170.283064439896748 -45.159925533539116,170.016169236147164 -45.202303128612925,169.81162941007284 -45.407387102030029,169.29977823356711 -45.499584570300733,169.07645936324846 -45.184216898774281,169.15435284452451 -45.047777015580564,169.289344957411231 -44.872187400108061,169.343107001901672 -44.827240672983216,169.321535135494116 -44.7665252963657,169.143283041481027 -44.712047221325612)) </text > <text > ... </text > </elementText > <elementText elementTextId =" 32193 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 52 " > <name > Author last name </name > <description > Last name of the Author </description > <elementTextContainer > <elementText elementTextId =" 32194 " > <text > Douglas </text > </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 52 " > ... </element > <element elementId =" 53 " > <name > Project type </name > <description > Is it an MSc, PhD, BSc(Hons) or PGDipSci? </description > <elementTextContainer > <elementText elementTextId =" 32197 " > <text > PhD </text > </elementText > <elementText elementTextId =" 32197 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 53 " > ... </element > <element elementId =" 54 " > <name > Advisers </name > <description > Who supervised/advised this student </description > <elementTextContainer > <elementText elementTextId =" 32199 " > <text > Landis, C.A. </text > </elementText > <elementText elementTextId =" 32199 " > ... </elementText > </elementTextContainer > </element > <element elementId =" 55 " > <name > Abstract </name > <description > The Abstract for this thesis </description > <elementTextContainer > <elementText elementTextId =" 32200 " > <text > Dunstan Formation lignite bearing strata within the 1,000m thick Miocene Manuherikia Group of Central Otago represent an important coal resource. Three principal coalfields, Blackstone, Roxburgh and Nevis are identified. Detailed stratigraphic and sedimentologic data from outcrop and over 120 boreholes were assessed to evaluate Central Otago coalfield stratigraphy and the paleoenvironmental controls governing peat deposition on a broad alluvial plain surrounding a large freshwater basin (Lake Manuherikia). Six complexly interrelated Dunstan Formation members are identified; each member represents a distinctive depositional system that is subdivided into sequences comprising genetically related lithofacies recognized by an abbreviated mnemonic code. Depositional systems recognized are: 1. Braided river deposits of the St Bathans Member occurring at the base of the group, infilling valleys entrenched in the weathered schist and greywacke basement. They incorporate deposits of major channels and a diverse range of shallow minor channels dominated by bar and dune bedforms. 2. Fine grained alluvial plain deposits of the Fiddlers Member and Middle Old Woman Submember. The former represents an extensive long-lived fluvial plain traversed by meandering channels dispersing sediment into muddy flood-basins and Lake Manuherikia. Locally, muddy and peat-forming swamps replaced abandoned splay filled flood-basins. 3. Anastomosed fluvial deposits of the Lower Old Woman· Submember. Stabilized river channels were bordered by long-lived muddy flood-basins and peat-forming swamps, producing thick laterally discontinuous deposits of lignite, gravelly sand and mud. 4. Carbonaceous rich delta plain deposits representing Blackstone and Teviot Members developed at major points of sediment entry into Lake Manuherikia. Complexly interdigitating fine grained facies representing short-lived peat swamps, well drained swamps, interdistributary bays, levee and distributary channels accumulated on the lower delta plain, contrasting with the long-lived peat-forming backswamp environment that dominated the upper delta plain- lower alluvial plain landscape. 5. Marginal lacustrine deposits of the Kawarau Member represent a stagnant swampy shoreline interdigitating with interdistributary bays (Cromwell Submember) and a current agitated terrigenous lake margin (Ewing Submember) of beaches, mudflats, backbarrier lagoons and bays. Ostracods, algae (including oncolites), fish and bird remains are dispersed within shoreline facies. An enlarging Lake Manuherikia progressively onlapped older lake margin and alluvial plain strata, depositing a thick (700m) pile of sandy and muddy (including richly kerogeneous) sediments (Bannockburn Formation), blanketing an area in excess of 5,600 km2. Extraordinary thick coal beds of the 33 - 90 m thick Johnstone and McPherson Seams {Blackstone and Teviot Members) accumulated in long-lived backswamps of upper delta plain-lower alluvial plain environments. Thin (< Sm thick) laterally discontinuous coal beds with numerous splits occurring in the upper portions of these seams accumulated in short-lived lower delta plain swamps, adjacent to a network of interdistributary bays and distributary channels. Fluvial plain peats primarily accumulated in swamps that enveloped infilled flood-basins of the broad low gradient Fiddlers alluvial plain, or they accumulated (like the deposits of the 24m thick Ben Nevis Seam) in long-lived swamps on the Old Woman alluvial plain, adjacent to stable anastomosed channels. In fluvial settings, coal quality, seam configuration, frequency and thickness of partings was primarily influenced by channel overbank and splay sedimentation. Almost total abandonment of Old Woman flood-plain alluviation and a sustained high water table were conducive to the development of the laterally extensive 22m thick Homestead Seam of the Upper Old Woman Submember. At the lake margin, peat-forming swamps interdigitating with interdistributary bays produced the numerous thin {< 5m thick) , laterally discontinuous coal beds constituting the Kawarau Seam. Cyclic repetition of these coal beds was governed by fluctuating lake levels. The study emphasizes the significance of detailed observations and analyses of coal-bearing strata, demonstrating the potential role of paleoenvironmental modeling in coal exploration and mining activities. </text > <text > ... </text > </elementText > <elementText elementTextId =" 32200 " > ... </elementText > </elementTextContainer > </element > <element elementId =" 59 " > <name > Department </name > <description > The department where the student is studying primarily. </description > <elementTextContainer > <elementText elementTextId =" 32201 " > <text > Geology </text > </elementText > </elementTextContainer > </element > <element elementId =" 61 " > <name > Named locality </name > <description > Named locality describing the field area location. </description > <elementTextContainer > <elementText elementTextId =" 32202 " > <text > Otago </text > </elementText > <elementText elementTextId =" 32203 " > <text > Central </text > </elementText > <elementText elementTextId =" 32203 " > ... </elementText > </element > <element elementId =" 60 " > <name > Thesis description </name > <description > Number of pages, maps, CDs, etc. </description > <elementTextContainer > <elementText elementTextId =" 32208 " > <text > x, 368 p. : ill. 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(Barry James), 1947- </text > </elementText > </elementTextContainer > </element > <name > Date </name > A point or period of time associated with an event in the lifecycle of the resource <elementTextContainer > <elementText elementTextId =" 32196 " > <text > 1986 </text > </elementTextContainer > </element > <element elementId =" 50 " > <name > Title </name > <description > A name given to the resource </description > <elementTextContainer > <elementText elementTextId =" 32198 " > <text > Lignite resources of Central Otago. Manuherikia group of Central Otago, New Zealand : stratigraphy, depositional systems, lignite resource assessment and exploration models </text > </elementText > </elementTextContainer > </element > <element elementId =" 49 " > <name > Subject </name > <description > The topic of the resource </description > <elementTextContainer > <elementText elementTextId =" 32204 " > <text > Cenozoic </text > </elementText > <elementText elementTextId =" 32204 " > ... </elementText > <elementText elementTextId =" 32205 " > <text > Coal geology </text > </elementText > <elementText elementTextId =" 32205 " > ... </elementText > <elementText elementTextId =" 32206 " > <text > Lithostratigraphy </text > </elementText > <elementText elementTextId =" 32206 " > ... </elementText > <elementText elementTextId =" 32207 " > <text > Sedimentology </text > </elementText > <elementText elementTextId =" 32207 " > ... </elementText > </elementTextContainer > <elementTextContainer > ... </elementTextContainer > </element > <element elementId =" 49 " > ... </element > </elementContainer > <elementContainer > ... </elementContainer > </elementSet > <elementSet elementSetId =" 1 " > ... </elementSet > </elementSetContainer > <elementSetContainer > ... </elementSetContainer > <tagContainer > <tag tagId =" 433 " > <name > deltoid sedimentation </name > </tag > <tag tagId =" 433 " > ... </tag > <tag tagId =" 432 " > <name > fluvial sedimentation </name > </tag > <tag tagId =" 432 " > ... </tag > <tag tagId =" 434 " > <name > lacustrine sedimentation </name > </tag > <tag tagId =" 434 " > ... </tag > <tag tagId =" 431 " > <name > lignite </name > </tag > <tag tagId =" 431 " > ... </tag > <tag tagId =" 430 " > <name > Manuherikia Group </name > </tag > <tag tagId =" 430 " > ... </tag > </tagContainer > <tagContainer > ... </tagContainer > </item > </itemContainer >
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Relationships | Scarleteen Relationships Q is for Questioning What's it mean to be questioning, why would you or someone else identify that way, how do you deal in the process and how might you answer the question? Hello, Sailor! How to Build, Board and Navigate a Healthy Relationship You probably hear the term "healthy relationship" a lot. But what does that mean, and how do you create -- and keep building -- one of those? Love the Glove: 10 Reasons to Use Condoms You Might Not Have Heard Yet You've probably heard or thought some things about condom use that might be keeping you or others from using them or from using them consistently, and I'm willing to bet you haven't heard everything I'm about to say. Even if you're already using condoms and using them every single time properly, I bet you know someone -- a sibling, a friend, a sexual partner -- who could stand to hear ten great reasons to use condoms. Love Letter I'm writing this because someone told you that you can't understand or experience love at your age. If no one did yet, they probably will soon enough. I'm writing to tell you that if you've heard that, I just don't think it's true. Polyamorous? Does That Mean You Like Parrots? One teen's experience with loving in plural. Getting Through a Breakup Without Actually Breaking Breakups sure can suck. But you can get through them, and come out on the other side okay. Find out what can make that easier, what can make them harder, and some ways to help yourself with so you can deal, heal and get back to the business of being your kickass self. About That "Talk" with Your Parents... Talking with your parents about sex can be really hard – even if your parents are really open and start the conversation themselves rather than you starting it – or even if your parents are totally supportive of your boyfriend or girlfriend and your sexual activities. Here are some tips and helps to make it easier on both of you. An Immodest Proposal Just last Tuesday, right down the street from you, or perhaps even right where you live, two teenagers had sex for the very first time, and it was exactly as we all wish those first experiences to be. Or was it? Why I Deeply Dislike Your Older Boyfriend He may be older but he's not wiser, and he's not acting like a grownup. He doesn't want to grow up, which is part of why he's dating people he perceives as not grownup themselves. He also doesn't have the bad stuff that happens to you because of him happen to him to make him want to change: if he was in your shoes, he'd ditch him in a heartbeat. What's Age Got to Do With It? Is your boyfriend or girlfriend more than a couple of years older than you? Here’s a scoop on age differences and what to watch out for. « first ‹ previous … 4 5 6 7 8 9 10 11 12 next › last » Related Advice Lots of sex, but why a dry spell now? He wants me to prove I love him by having sex. It's normal to start a family in the military, but do you think he's ready? Am I only able to have sex without emotions? Is this just about BDSM fantasy, or is he paying for a dominatrix? I'm not ready...but am I just overthinking it? No bleeding with intercourse and changes to my vagina have him making false accusations. He's so perfect, and I feel too self-concious for intimacy! Is our spark fading because I kissed his best friend...or something else? Shooting blanks or a loaded gun? ‹‹ Page 10 ››
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(PDF) Geomorphic Assessment of the Lower White River: Valley Landform Delineation, Reach Typing, and Geomorphic Condition Assessment. PDF | The first comprehensive Geomorphic Assessment of the Lower White River, Utah and Colorado, including valley landform delineation, river reach... | Find, read and cite all the research you need on ResearchGate Technical Report Geomorphic Assessment of the Lower White River: Valley Landform Delineation, Reach Typing, and Geomorphic Condition Assessment. February 2019 DOI: 10.13140/RG.2.2.28838.57924/1 Affiliation: Utah State University Authors: <here is a image 48756c123e7ca6e2-3eee13be077f9397> Gary R O'Brien Utah State University <here is a image ff0b81e4b5e35be0-c96ff48ab318a7c5> Geoff Stevens Utah State University <here is a image 3e007f68deb23896-76a69df1a2620adc> William Wallace Macfarlane Utah State University <here is a image df8eb1ffceacda01-cc22c2815897ab38> Joseph M. Wheaton Utah State University Abstract and Figures The first comprehensive Geomorphic Assessment of the Lower White River, Utah and Colorado, including valley landform delineation, river reach typing, geomorphic condition, 80-year channel change record, results of riparian condition assessment (R-CAT), and case study scenarios of endangered fish and invasive vegetation removal. <here is a image d7531ebcef779714-89bbe84ace66263d> Summary of main geomorphic findings for the lower White River from Kenney Reservoir to confluence with Green River. From top: channel confinement and constriction; channel sinuosity, geomorphic condition and reach types. Grey background indicates interval of BLM managed land highlighted in our BLM study reaches. … <here is a image aa507c9616a8ce81-40f96fa3cf77bafd> Shows layers produced from the confining margin analysis. (A) Refined valley bottom polygon overlying original VBET output valley bottom, showing explicit confinement margins by precise mapping of fans, terraces, and valley margins; (B) Valley bottom polygon overlain by valley landforms, mapped by Tier 2 geomorphic attributes; (C) planform and channel midline mapped as bankfull width. Images are Google Utah imagery 2015. … <here is a image 6fb109b8e1cb077c-567d974df5cb8dc5> The lower White River shown over a portion of the Lower White watershed. Map shows valley setting, depicted as channel and valley confinement resolved as laterally unconfined, partly confined, and confined valleys. … <here is a image ac1bd9cfd3290d6a-4936de90a944a2f0> Schematic showing the extent and types of potential confining margins in the lower White River in Utah. Valley landforms are shown as polygons and valley margin geomorphic units are shown as a polylines. Both are delineated as Tier 2 geomorphic units … <here is a image ef67627908e5eeb2-4b346d1db56c98af> +2 alley edge confining margin data per reach types, for the Utah portion of White River. … Figures - uploaded by Gary R O'Brien GEOMORPHIC ASSESSMENT OF THE LOWER WHITE RIVER Valley Landform Delineation, Reach Typing and Geomorphic Condition Assessment Lower White River, Utah. Photo credit, Jerrad Goodell Prepared by: Gary O'Brien , Geoff Stevens, Wally Macfarlane, and Joe Wheaton Department of Watershed Sciences,5210 Old Main Hill, Logan, UT 84322 - 5210 White River Geomorphic Assessment Prepared for: Bureau of Land ManagementUtah State Office 440 W 200 S #500, Salt Lake City, UT 84101 Dec ember2018 Recommended Citation: O’Brien G ., Stevens G ., Macfarlane W., and Wheaton, J.Geomorphic Assessment of LowerWhite River : Valley Landform Delineation, Reach Typing and Geomorphic Condition Assessment. Prepared for Bureau of Land Management . Utah State University Ecogeomorphology & Topographic Analysis Lab.Logan, UT. 99 Pages. White River Geomorphic Assessment 3 of 99 CONTENTS List of Figures ................................................................................................................................................................5 Executive Summary .......................................................................................................................................................7 Definitions ................................................................................................................................................................ 10 Project Background and Purpose ................................................................................................................................ 11 Regional background ................................................................................................................................................... 11 Geographic setting ................................................................................................................................................... 11 Geology and Geomorphic setting ........................................................................................................................ 14 Land use .............................................................................................................................................................. 17 Methods ....................................................................................................................................................................... 21 Study areas ............................................................................................................................................................. 21 River classification and geomorphiccondition ......................................................................................................... 23 Reach Type Classification ................................................................................................................................... 23 Valley Setting and Channel Confinement ............................................................................................................ 24 Geomorphic Condition ......................................................................................................................................... 26 Model inputs and tools ............................................................................................................................................. 28 Mapping the Valley Margin .................................................................................................................................. 29 Mapping Valley Margin Geomorphic Un its.......................................................................................................... 30 Application of model improvementsin BLM study areas ......................................................................................... 34 Riparian Condition Assessment Toolbox (R - CAT) ................................................................................................... 35 Channel change methods ........................................................................................................................................ 39 Methods for Analyzing Stream Channel Change through Time Using Georeferenced Imagery ......................... 39 Results – Assessment of geomorphic stream and valley attributes ............................................................................. 40 Reach types –characteristics of river form and function ......................................................................................... 41 Valley setting of lower White River ...................................................................................................................... 41 Reach type distribution ........................................................................................................................................ 42 Reach type descriptions ...................................................................................................................................... 44 Geomorphic Condition ............................................................................................................................................. 51 Explanations of geomorphic condition ................................................................................................................. 55 Results of mapping the valley margin ...................................................................................................................... 56 Map of the valley margin and confining margin geomorphic units ....................................................................... 57 Refined valley bottom .......................................................................................................................................... 59 Bureau land management study reach A (BLM - A) .................................................................................................. 60 Confining margin geomorphic units ..................................................................................................................... 61 Bureau land management study reach B (BLM - B) .................................................................................................. 64 Partly confined valley, low sinuosity planform - controlled gravel bed ................................................................... 84 Partly confined valley, moderate sinuosity, planform -controlled discontinuous floodplain ................................... 85 Unconfined valley, low - sinuosity gravel bed ........................................................................................................ 87 Unconfined valley, meandering gravel bed ......................................................................................................... 88 Appendix B: Methods for Analyzing Stream Channel Change through Time Using Georeferenced Imagery ......... 90 White River Geomorphic Assessment 5 of 99 LIST OF FIGURES Figure 1 –Summary of main geomorphic findings for the lower White River from Kenney Reservoir to confluence with Green River. From top: channel confinement and constriction; channel sinuosity, geomorphic condition and reach types. Grey background indicates interval of BLM managed land highlighted in our BLM study reaches. ....................9 Figure 2 –US EPA Level 4 Ecoregions for the Lower White River watershed. ........................................................... 13 Figure 3 –Temperature and precipitation data for period of record 1894 -2016, for Rangely, CO. Mean annual precipitation in Rangely, CO is 10.0 in. At Bonanza near theUtah border it is 8.8 in., and at the mouth near Ouray,UT, is 6.4 in. Western Regional Climate Center (2013). Cooperative Climatological Data Summaries. Retrieved from: https://wrcc.dri.edu/summary/Climsmut.html ......................................................................................................... 14 Figure 4 – Geology of the Lower White River watershed in Utah and Colorado, showing rocks and surficial deposits of the Uinta Basin and eastward uplands. ........................................................................................................................ 15 Figure 5 – Stratigraphic section for Uinta Basin sedimentary sequence. Note that the rocks depicted here are the majority of thoseunderlying the White River from Kenney Reservoir to the Green River Confluence, although older strata are important in the context ofthe Lower White River watershedand are shown on Figure 4 (Modifiedfrom Hintze and Kowallis, 2009; Sprinkle,2007, 2009) ........................................................................................................ 16 Figure 6 – Location and extent of Natural Buttes natural gas field comprising surface and subsurface rocks of the Eocene Uinta and Green River Formations (modified from Wood and Chinsey, 2015). .............................................. 18 Figure 7 –Combined peak flows and average annual flows for the White River, near Watson, Utah. ........................ 20 Figure 8 –Daily discharge for White River near Watson, Utah for period 10 -2017 to 10 -2018. Aerial photography used to complete this geomorphic assessment was taken on July 21, 2015, at a discharge of ~1780 cfs. .......................... 21 Figure 9 –Areas of focus in this study: (1) the entire Lower White River watershed; (2) from Kenney Reservoir to the mouth; (3) from Utah border to the mouth; (4) study reaches within BLMowned land. ............................................... 22 Figure 10 –Procedural tree for reach types delineated in the White River watershed (note: this is not a dichotomous key; each top category simply includes the features below it or not). .......................................................................... 24 Figure 11 –Schematic of valley settings identified in this report (alsosee Table 1). ................................................... 25 Figure 12 –Confinement depicted for a confined and unconfined valley settings (fromO'Brien and Wheaton (2015). The diagram on the left has little or no adjustment potential, whereas the diagram on the right possesses very high lateral and even vertical adjustment potential. Arrows indicate the vertical and lateral adjustment possible for each valley setting. ............................................................................................................................................................... 27 Figure 13 –Shows layers produced from the confining margin analysis. (A) Refined valley bottom polygon overlying original VBET output valley bottom, showing explicit confinement margins by precise mapping of fans, terraces, and valley margins; (B) Valley bottom polygon overlain by valleylandforms, mapped by tier 2 geomorphic attributes; (C) planform and channel midline mappedas bankfull width. Images are Google Utah imagery 2015 . ............................ 33 Figure 14 –Conceptual diagram of the Valley Bottom Extraction Tool (V -BET) workflow showing the input data required and the seven processing steps. .................................................................................................................................. 36 Figure 15 –A conceptual diagram of the riparian vegetationdeparture index showing how mid points of the drainage network (1) are used to generate Thiessen polygons (2) andhow these polygons are buffered by the resolution of the vegetation data to ensure that vegetation data is completely contained within the valley bottom in headwater reaches (3) . Riparian vegetation departure is calculated using the ratio of existing area of native riparian vegetation (4) to historic area of native riparian vegetation (5) and the output is a segmented drainage network containing riparian departure from historic condition scores (6). ................................................................................................................................ 37 Figure 16 –Conceptual diagram of riparian condition assessment (RCA) tool showing how midpoints of a drainage n etwork (A) are used to generate Thiessen polygons (B). Riparian vegetation departureindex outputs (C) are combined with land -use intensity (D) and floodplain accessibilityoutputs (E) within a Fuzzy Inference System (F)to produce a segmented drainage network containing riparian condition assessment scores (G). .................................................. 38 Figure 17 – Example of results of channel change analysis for White River on BLMowned land, between 1936 and 2016. This image shows bankfull width polygons digitized for both datasets, as well as channel offset due to lateral stream adjustment. ....................................................................................................................................................... 40 White River Geomorphic Assessment 6 of 99 Figure 18 – The lower WhiteRiver shown over a portionof the Lower White watershed. Map shows valley setting, depicted as channel and valley confinement resolved as laterally unconfined, partly confined,and confined valleys. 42 Figure 19 –LowerWhite River shown resolved as reach types from Taylor Draw Dam (Kenney Reservoir) to c onfluence with the Green River. ................................................................................................................................................... 44 Figure 20 –Unconfined valley, meandering gravel bed reach type. Scroll bars and cutoff meander loops are indicated on the photograph. Arrows show the direction of meander scrolling or adjustment, leading to successivescroll bars. ..................................................................................................................................................................................... 45 Figure 21 –Unconfined valley, low sinuosity gravel bed reach type. ........................................................................... 45 Figure 22 –Partly confined valley, anabranching reach type. ...................................................................................... 46 Figure 23 –Partly confined valley, meandering planform discontinuous floodplain reach type. .................................. 47 Figure 24 –Partlyconfined valley, moderate sinuosity,planform -controlled discontinuous floodplain reach type. Examples of discontinuo us floodplains are outlined in red. .......................................................................................... 47 Figure 25 –Partly confined valley, lowsinuosity, margin -controlled discontinuous floodplain reach type. .................. 48 Figure 26 –Partly confined valley, low - sinuosity, fan - controlled discontinuous floodplain reach type. ....................... 49 Figure 27 –Partly confined valley, lowsinuosity planform -controlled gravel bed. ....................................................... 49 Figure 28 –Confined valley, margin - controlled gravel bed. ......................................................................................... 50 Figure 29 –Confined valley, entrenched bedrock canyon. .......................................................................................... 50 Figure 30 –Lower White River belowKenney Reservoir resolved as geomorphic condition. ..................................... 54 Figure 31 – Explanation of geomorphic condition for variants of the partly confined valley, low sinuosity margin - controlled gravel bed reach type. ................................................................................................................................. 56 Figure 32 –Schematic showing the extent and types of potential confining margins in the lower White River in Utah. Valley landforms are shownas polygons and valley margin geomorphic units are shown as a polylines. Both are delineated as Tier 2 geomorphic units (see Table 3). .................................................................................................. 58 Figure 33 –Comparison ofvalley bottom polygons producedfor this study. The VBET output is shown in red, whereas the refined confining margin is shown in light green. ................................................................................................... 60 Figure 34 –Confinement classification and confining features shown for BLM - A. ....................................................... 61 Figure 35 –Valley edge confining margin data per reach types, for the Utah portion of White River. ......................... 63 Figure 36 –Valley edge confining margin data per reach types, for the BLM study reach B. ...................................... 65 Figure 37 –Riparian Vegetation Departure outputs for the Lower White River watershed. ......................................... 67 Figure 3 8 –Riparian Vegetation Conversion Type (RVCT) outputs for the Lower White River watershed. ................. 68 Figure 39 –Riparian Condition Assessment outputs for Lower White Riverwatershed. ............................................. 69 Figure 40 –Average bankfull channel area reduction from 1936 to 2016 for BLM managed land along the White River in Utah and Colorado. .................................................................................................................................................. 71 Figure 41 – Tamarisk and Russian olive removal sites shown in context with corresponding reach types. ................. 73 Figure 42 – Distribution of spawning habitat and pit tag detected native fish species in the White River, 2013 - 2015. Reproduced from Budy, 2014, unpublished data, and Fiorelli and Breen (2015). ........................................................ 74 Figure 43 – Explanation of geomorphic condition for variants of the Confined valley, margin - controlledgravel bed reach type. ............................................................................................................................................................................. 81 Figure 44 –Explanation of geomorphic condition for variants ofthe partly confined valley, low sinuosity margin - controlled gravel bed reach type. ................................................................................................................................. 82 Figure 45 – Explanation of geomorphic condition of partly confined valley, fan - controlled discontinuous floodplain reach type. ............................................................................................................................................................................. 84 Figure 46 – Explanation of geomorphic condition of partly confined valley, planform -controlled gravel bed reach type. ..................................................................................................................................................................................... 85 Figure 47 –Explanation of geomorphic condition of partly confined valley, moderate sinuosity, planform - controlled discontinuous floodplain. .............................................................................................................................................. 86 Figure 48 – Explanation of geomorphic condition of unconfined valley, low sinuosity gravel bed. ............................... 88 Figure 49 – Explanation of geomorphic condition of unconfined valley, meandering gravel bed reach type. .............. 89 White River Geomorphic Assessment 7 of 99 EXECUTIVE SUMMARY • This report, contracted by the Bureau of Land Management (BLM), provides an assessment of geomorphic attributes and geomorphic condition for the lower White RiverbelowKenneyReservoir to the Green River confluence and presents a framework formodeling the geomorphic units of the valley that form confining margins of the river. • The Lower White River watershed (7000 km 2 ) resides within the northernmost region of the Colorado Plateau P hysiographicP rovince . The riverdescends through and intersects three EPA Level IV Ecoregions consisting of arid and semiarid desert plateau country,and includesthe oil and natural gas -rich Uinta Basin. • We identified nine riverreach types between Kenney Reservoir and the confluence with Green River, based on valley setting (extent of channel confinement), floodplain areal extent,channel planform and sinuosity, and the nature of the channel bed material. We identified and mapped two reach types inconfined valley settings (15 km), five reach types in partly -confined settings(103 km), and two reach typesin laterally unconf ined valley settings (63 km) ( Figure1). • T he lower White River is in good geomorphic condition despite considerable human impact adjacent to and in some cases in th e floodplain or in the channel. Impacts are mostly from municipal, agricultural and economic (oil and gas extraction infrastructure) development .There are 5 good (91 km), 7 moderate (61 km) and 4 poor (23 km)geomorphic condition variants of the nine reach typesalong the river .Yet within 53 km of BLM - owned land we studied, only 2 km were assessed in moderate or poor condition. • Calculation of channel confinement and modeling of the valley bottom forthe lower White River were derived from GIS-based tools(Confinement Tooland Valley Bottom Extraction T ool (VBET) , respectively) . Additionally, we mappedvalley geomorphic units and valley landformsalong 322 km of the valley margin along both banks.The mapping was done manually bya trained geomorphologist usinghigh - resolution air photos from 2017. Together, the valleygeomorphic units and valley landforms comprise the potential confining margin of the river channel (the margin of potential channel contact). This new, combined dataset represents a refined valley bottom useful for analyzing controls on channel morphology and floodplain extent. • We analyzed channel change for the lower White Riverbetween 193 6and 2017 within BLM - owned tracts in Utah. Results of the active channel shows that capacity for late ral adjustment , an important stream characteristic measuring geomorphic and habitat diversity, is high in the lower White River. However, channel widths have narrowed in the last 8 1 yearswith the onset of successful colonization by invasive species. • Reach type, geomorphic condition, confinement, sinuosity and valley geomorphic unitand landform analyses were completed forthe lower WhiteR iver between KenneyReservoir and theconfluence with Green River, and in greater detail for53 km of BLM -managed public land tracts .All of these analyses were interpreted, delineated and calculated entirely by manual techniques. Five of nine reach types were found within the BLM -managed public landtracts, dominated by partly confined valley settings. Potential and White River Geomorphic Assessment 8 of 99 active confining margins are dominated by bedrock , colluvium -mantled hillslope, and alluvial fans. This is similar to proportions found on thelower river between KenneyReservoir and the confluence withGreen River ( Figure1). • Case study: T amariskand Russian olive treatment areascorrelate with reach types in BLM managed areas that have higher adjustment potential, and therefore may respond favorably to removal efforts. • Across the Lower White River watershed, the RVD tool revealed roughly81% of the perennial drainage network showed significant to large departures from historic condition indicating that riparian vegetation along the vast majority of watershed’s drainage network have been significantly altered since Euro - American settlement. These departure patterns are distinct with much lowerdeparture scores on the mainstem compared to the tributaries. • The RVCT output for Lower White River watershed identified conversion to grass/shrub (27%) was themost common conversion followed by conversion to invasive species (19%) where tamarisk and Ru ssian olive invasion is common . The ‘negligible departure’ balance (35% of all perennial riparian areas) were ev enly distributed throughout the mainstemand the tributaries of the watershed’s drainage network. • Across the Lower White Riverwatershed, the RCA tool showed that roughly72 % of unconfined valley bottoms were in moderate to very poorriparian condition .Floodplains ofthe mainstem where agricultural uses are commonwere frequently in moderate to poor condition ( Figure37 . ). In contrast, i ntactand good condition were common in publicly -owned floodplain ecosystems along the mainstem White River where transportation infrastructure and intensive land use s are notcommon . M oderate to poorcondition floodplains occurred throughout the perennial tributaries, often corresponding to rural land use common along these river corridors. White River Geomorphic Assessment 9 of 99 Figure 1 – S ummaryof main geomorphic findings f or thelower White River from KenneyReservoir to confluence with Green River. From top: channel confinementand constriction ; channel sinuosity, geomorphic condition and reach types. Grey background indicates intervalof BLM managed land highlighted in ourBLM study reaches . White River Geomorphic Assessment 10 of 99 DEFINITIONS Terms relating to geoprocessing and geomorphology used throughout this report and are defined in Table 1. These terms mostly relate to adiscussion of the valley, channel and floodplain that are important in this geomorphic assessment of the lower White River. Table 1 . Definitions of geomorphic terms used in this study . See Figure 11 for a graphical overview of these terms (modified in part from Table 1, Fryirset al. (2016) ). Term Definition Valley confinement The position of the channel on the valley floor and the degree to which the active channel is in contact with potential confining margins on either bank. In this study, we defined this as confined , partly - confined, and laterally unconfined. Channel marg in The channel margin is the edge of the active channel (in many systems this corresponds with a bankfull margin). The channel margin is the boundary between where regular fluvial flows take place and other areas (e.g. floodplains where less frequent fluvial flows take place; terraces, where historic fluvial flows took place; hillslopes where fluvial flows do not take place). Confining margin Any section of channel margin (either side) that abuts against a valley margin or valley bottom margin (for natural settings) and/or anthropogenic margins (for human -impacted settings). The confining margin is not defined by what provides the confinement (e.g. levee vs. bedrock valley wall), but instead by what the channel is currently abutting against. Valley bott om The valley bottom comprises the channel and the contemporary (active) floodplain. Valley margin The valley margin is defined at the transition between the valley floor and bedrock hillslopes. This includes not just bedrock outcrops, but also regolith and soils derived from non - alluvial sources. The valley margin comprises the valley bottom and the inactive floodplains (i.e. terraces) and fans (both alluvial and colluvial) (see Figure 11 ). Valley floor landforms Or “Valley landforms” Landforms that are part of the valley perimeter (excluding the floodplain), that, along with the valley margin, form the potential confining margin. In this study, they are fans and te rraces. Valley bottom margin The valley bottom margin separates the valley bottom landforms(e.g., floodplain geomorphic units) from other valley landforms (e.g. fans and terraces) and/or upland and hillslope landforms. Confined, partly confined and laterally unconfined valley settings are defined by the extent of the valley bottom margin . Potential confining margin Any margin or border of the valley or valley landform where the channel could potentially be confined against either bank (see Figure 11 ). Constriction Length of channel that is in contact withconfining margins along both banksin proportion to a given stream length. Channel sinuosity The ratio of channel length to straight line distance of the channel, a measure of channel curvature. Valley sinuosity The ratio of valley length to straight line distance of the valley, a measure of valley curvature in contrast to the channel flowing wit hin it. White River Geomorphic Assessment 11 of 99 PROJECT BACKGROUND AND PURPO SE The main purpose of this study is to reportand discuss findings of a geomorphic assessment of t he lower White River, from Taylor Draw Dam ( Kenney Reservoir) to the confluence with the Green River.The report is divided intotwo parts. In part one, we describe an overview of the landscape and its building blocks followed by a classification of the various channel types and their relative conditions. The initial step of thegeomorphic assessment wasto determine ri ver character (form) and behavior(function). We analyze valley and channel confinement, channel sinuosity and planform, bed material, and in - channel (where visible) and out - of-channel geomorphic units .We do this for the entire lower White River below thereservoir, and for two focused study reaches entirely spanning BLM land in Utah. We also provide a study of channel change over the period of 193 6-present, where shifts inchannel position and width are detected and mapped. Finally, we examinedriparian c onditionthroughout the entire Lower White River watershedas an indication of overall geomorphic and habitat condition. In part two, we explore the geomorphology of the White River with the objective of providing a better set of tools for managers to understand the foundation of riparian and aquatichabitats within and adjacent tothe channel. To accomplish this, we discuss and present model inputs that build on existing GIS tools used to model the valley bottom and channel confinement. We present new precise mapping of the valley margin that significantlyrefines theextent of the valley bottom and partitions the valley edgeinto component geomorphic units and landforms that occupy the valley bottom . The geomorphic units and landforms maps are presente d in a simple tiered topology organizingthe landforms into fans and terraces ,and the valley edges into hillslope types —colluvium, talus, and bedrock.The new precise mapping and classifications accomplish three objectives: (1) provide s the basis for better understanding controls on channel behavior and habitat formation; (2) provides a basis for exploring potential new sediment sources to the channel and their effects onhabitat; and ( 3 ) set sthe stage to build an automated GIStool tha t will map valley geomorphic units, and differentiate valley confinement from valleybottom confinement. To explore these new innovations, w efocus on the geomorphic setting of thelower White River within two BLMstudy areas , discuss potentialsediment sources from the valley margins and how these nascent models might inform habitat quality and characteristics . We explore the hypothesis that modeling the wholevalley and a precisely delineated stream course together with our refined inputs will lead to a better depiction of geomorphic attributes in BLM managed portions of the river, and potentially, the ability to use these geomorphic attributes to actively interpre t native fish habitat elements throughout other reaches of the lower White River. This study was not funded to include field work , so the assessment was built entirely usingaerial photography and the use of GIS toolsto create digital depictions of the valley, valley bottom and stream course. We list the geomorphicattributes present in the lower White River individually and collectively, and highlight someinstances where attributes may indicateimproved or degraded habitat. REGIONAL BACKGROUND GEOGRAPHIC SETTING The White River is a west -flowing tributary of the GreenRiver origina tingin the Flat Tops Wildernesshigh plateaus of west Central Colorado. The L ower White River watershed (7000 km 2 ) resides within the northernmost region of the Colorado Plateau Physiographic Province .The rivers’ extent covered here lies at or below 5300’ asl, the elevation of White River Geomorphic Assessment 12 of 99 Kenney Reservoir and Rangely, Colorado. The average watershed elevation is 6880 ft. asl. This region descends through and intersects three EPA Level IV Ecoregionsconsisting of ar id and semiarid desert plateau country ( Figure 2). T he Shale Deserts and sedimentary basins under lie the White River from Kenny Reservoir to the Colorado - Utah border. This region is characterized byTertiary claystone, siltstone, mudstone and shale, forming broad alluvial valleys, with rolling hills, plains, basins, badlands and plateaus . This arid landscape is sparsely vegetated by brush and shrublands (i.e., sage, blackbrush and saltbrush) denuded by arroyos, and provide s asource of sedimentto the river through rampant erosion of soft rocks . T he S emiarid Canyonlandslie adjacent to and underlie portions of the river in both states. These are thehigh relief, disse cted plateau region consisting of benches and mesas, steep hillslopes, cliffs and alluvial fans underlain by Tertiary and Cretaceous siltstone and sandstones. It is covered by pinyon - juniper woodlands (mean annual precipitation 8 - 10 in ; Figure 3),Gamble Oak woodlands, and sage steppes. Surrounding the lower White River from the Utah border to the Green River, is the Uinta Basin F loor , an arid synclinal (saucer - shaped) basin containing streams andterraces, floodplains, rollinghills, mesas and benches.It is underlain by fine - grained rocks of the Eocene Uinta formation, and is coveredubiquitously by alluvial, eolian (wind -deposited), and coarse outwash deposits ( Figure4). The sparsely vegetated regionis mostly covered by sagebrush and saltbrush , arid soils and low annual precipitation(around 6.4 in. mean annual precipitation) and receives abundant runoff f rom mountain streams (Woods et al., 2001) . White River Geomorphic Assessment 13 of 99 Figure 2 – US EPA Level 4 Ecoregions for the Lower White River w atershed . White River Geomorphic Assessment 14 of 99 Figure 3– Temperature and precipitation data for period of record 1894 -2016, for Rangely , CO . Mean annual precipitation in Rangely, CO is 10.0 in. At Bonanza near the Utah border it is 8.8 in., and at the mouth nearOuray, UT , is 6.4 in. Western Regional ClimateCenter (2013). Cooperative Climatological Data Summaries. Retrievedfrom: https://wrcc.dri.edu/summary/Climsmut.html Geology and Geomorphic setting Origin and History The Lower White River watershed spans an area of eastern Utah and western Colorado that is characterized by structural deformation composedof a series of upwarps and downwarpsactivated during the late Cenozoic Laramide Orogeny about 66 - 40 million years ago. To the east in Colorado, the landscape is underlain mostly by Cretaceous and older rocksuplifted against the basin - fillstratigraphy of mostly Tertiary and younger age ( Figure 4 ). To the west in Utah, t he asymmetricUinta basin was formed in response to sediments eroded from the Uinta uplift (the present - day Uinta Mountains) into anadjoining topographic depression (The Uinta uplift -Uinta Basin “couplet”). It developed during early Tertiary time and contains up to 10,000 feet of lower Tertiary fluviatile and lacustrine deposits. During Eocene time (~50 - 30 million years ago ), largeregional lakes deposited thick sequences offine sediments and freshwater limestones. The younger lacustrine deposits became the Green River Formation, whose paleo landscape became one of the world’s only majornon -marine oil and gas sources (Carroll and Bohacs, 2001) .The thick sequences of fine sediments deposited in the basin have been subsequently uplifted and eroded, revealing badland topography (Hintze and Kowallis, 2009) . White River Geomorphic Assessment 15 of 99 Figure 4 –Geology of the Lower White River watershedin Utah and Colorado, showing rocks and surficial deposits of the Uinta Basin and eastward uplands. Lower White River transect through bedrock landscape The Utah portion of the White River canyon flows throughand intersects the Eocene Uinta formation, composed of fine- to very fine - grained sandstone and siltstone,minor conglomerate, shale, tuffaceousinterbeds ,mudstone and claystone. This is the bedrock exposed at river level and forming the overlyingcliffs, badlands, hillslopes and adjacent landscapes viewed from the river through BLM land(Sprinkle, 2007) .These fine - grained units areunderlain downstream of the UT-CO border by the Parachute Creek Member of the Eocene Green River formation, a moderately resistant, organic - rich marlstone, siltstone, sandstone, and oolitic limestone . The Green River Formation is a source of oil shale deposits, crude oil,and natural gas reserves(Dean and Anders, 1991; Sprinkle, 2009) . The dominantly fine -grained surficial geologic units imply that there is littleheterogeneity in this landscape with respect to sediment load to the White River (Figure 5). L ocal beds crop out as resistant cliff - forming exposures, but most bedrock exposures are sloping landscape expressions that resemble gentle hills and colluvial slopes, and can be distinguished as bedrock by theirprimary bedding that is often tilted . More resistant beds are the sourceof coarse colluvium and talus on hillslop es, and coarse material in fans and landslide deposits. White River Geomorphic Assessment 16 of 99 Figure 5– Stratigraphic section for Uinta Basinsedimentary sequence .Note that the rocks depicted here are the majority of those underlying the White River from Kenney Reservoir to the Green River Confluence, although older strata are important inthe context ofthe Lower White River watershedand are shown on Figure 4(Modified from Hintze and Kowallis, 2009; Sprinkle,2007, 2009) . White River Geomorphic Assessment 17 of 99 L and use Oil and Natural Gas resources and impacts The Uinta Basin is an asymmetric, structural trough. Oil and gas reserves are ubiquitous throughout the regionand accumulated in response to structuralcontrol of the basin to sedimentation. The configuration of the basin is controlled by pre -T ertiary structural trends(formation of anticline fossil fueltraps, for example) .Oil and gas accumulations are situated in response to these structural trends and their effect on Tertiary sedimentation(Osmond, 1992) . F luvial - lacustrine oil and gas reservoirs permeating the Eocene Green River Formation also contains coal beds and, oil shale beds, and tar sandbeds(Cashion, 1967; Dean and Anders, 1991) .Much of the oil and gas developed during lake - phase sedimentary dynamics during the Eocene .Surrounding the White River in the subsurface is the large Natural Buttes, Bonanza and Kennedy Wash natural gas fields, and north of the river, crude oil is recovered from the Gypsum Hills, Wonsits Valley, and White River oilfields (Wood and Chidsey, 2015) ( Figure 6) . The reservoirs are in Tertiary and Cretaceous rocks(Hintze and Kowallis, 2009) .The Natural Buttes natural gas field has over 400 wells spread across a continuous area of ~1000 km 2 . Roads and drilling are the greatest environmental impacts, and the infrastructure reaches the river at many access points. Shale oil development Oil shale exists in the beds of the Green River Formation. Attempts have been made to mine and refine shale oil from deposits close to the White River, with plans to place a reservoir mid - channel to facilitate operations. Oil shale developments require large quantities of water for their operationsthat are either pumped as ground water or diverted from the stream (Boyle et al., 1984) .There are plans to reopen oil shale refinery activities in the vicinity of the previously closed White River Mine (landleased by BLM)(Aho, 2015) . White River Geomorphic Assessment 18 of 99 Figure 6– Location and extent of Natural Buttes n atural gas f ieldcomprising surface and subsurface rocks of the Eocene Uinta and Green River Formations (modified from Wood and Chinsey, 2015) . Agriculture and urbanization The White River basin is less than 1% developed (Ries Iii et al., 2017) (National land cover dataset , https://www.mrlc.gov/2018/ ). Valley bottom floodplain farming and grazing was a natural draw for settlers who first inhabited the openWhite River valley near Rangely, CO., because soils are fertile, fine, and well sorted; water is plentiful, and the landscape is accessible and flat. Farming operations extend 25 kmdownstream of Kenney Reservoir . Downstream of this, the alluvial valley becomes narrow , lacks roads, and bedrock walls restrict accessibility. Valley bottom floodplainfarming is also the primary local economic resource upstream of the reservoir for more than 100 km, in the vicinities of White River City and Meeker, CO., where adjacent landscapes are rugged and not suitable for large scale agriculture. I mpacts to the natural riparian environment and stream ecology of the lowerWhite River include water quality changes from application and subsequent runoff of fertilizers and sewage (point - source pollution) (Lentsch et al., 2000) , and water temperature changescaused byriparian cover removal .F loodplain development, soil compaction and channel course stabilization (prevention of channel adjustment) ,stream diversion for floodplain irrigation and out - of - channel mining, industrial and urbanization operations(Aho, 2015)(Boyle et al., 1984)pose most of the challenges to maintaining a healthy riverscapeand suitable habitat for threatened and endangered species offish (e.g., Haines et al., 2004) ,andaccount for deviations from good geomorphic condition cited in this repor t. White River Geomorphic Assessment 19 of 99 H yd rology and flood control in the lower White River Watershed The White River basin covers 12,969 km 2and includes the Lower White ( 7064 km 2 ); UpperWhite (3534 km 2 )and Piceance - Yellow Creek (2371km 2 ) watersheds. It generates annual average flows of around 680 cfs(cubic feet per second) ( USGS gauge 09306395, near Utah -Colorado border ). Annual flows of 660 - 690 cfs have been remarkably consistent over the last 100years or so of record ( Figure 7). The a verage annual flow atmouth of White River is 836 cfs, so it picks up a few hundred cfs on average from downstream tributaries . Peak discharge averages 3800 cfs but has declined from p re -dam average of ~4200 cfs to about 3000 cfs annually since Taylor Dam was installed and n ow provides flood control . Yet dam controlled flows do not dampen the natural hydrograph significantly and shows a typical pattern of low flow in the winter, a climbing limb in the spring,and peak runoff in the summer ( Figure 8). Pre -and post - dam hydrographs are not significantly different (cf. Grams et al., 2013). The average2 -year flood is 4200 cfs (Ries Iii et al., 2017) .Haines et al. (2004) recommended a continuation of base flows to support native fish species, whereas Schmidt and Orchard (2002) determined that flows of 1400 cfs were required to maintainthe channel configuration , and flows ranging 150 -600 cfs were required to maintain habitat (e.g., riffle s and pools;in this case, for Colorado Pike Minnow ). These parameters fall wellwithin the historic average flows of the river shownin Figure 7 and in recent, contemporary flows ( Figure 8) . Figure 8also shows the year (201 5) foraerial imagery used in this study;it was taken June 21, 2015, so interpretations of channel type and condition were based on flows of ~ 1780 cfs. The White Riv er is dam - controlledbyTaylor Draw Dam(Kenney Reservoir) , located above Rangely, CO. It operates under guidelines of a Federal Energy Regulatory Commission permit requiring “run of the river” management, meaning that under the guidelines, waterleaving the reservoir must equal the amount of water entering the reservoir, with minor alterations allowed forhydroelectric power generation(Rio Blanco Water Conservancy District; Haines et al., 2004)Thus, the hydrographs have not been significantly altered. Behind the dam, Kenn e y Reservoir provides water for recreation, flood control, and irrigation water for agriculture andmining operations , includingfor shale oil (Aho, 2015) . Reservoircapacity is declining quickly through rapid siltation (i.e., from 13800to 8000 acre feet of storage since 1983, about 315 acre feet per year). Flow over the dam is not regulatedper se, but a 2 -megawatt generator comes on line during peak flows of the sea son . (City of Rangely, Co ; https://www.colorado.gov/pacific/townofrangely/taylor -draw - dam-Kenney -reservoir ). Plans are currently being promoted to build a new 90,000 ac. ftreservoir in Wolf Creek near Meeker, CO., upstream of Kenney Reservoir. This new impoundment project would not be built on the White Riverbut would pump and maintain all its water fromthe White, creating uncertain effectson currentfisheries (Conservancy ), and possiblybe allocated for oil -gas and oil shale operations. White River Geomorphic Assessment 20 of 99 Figure 7 –Combined peak flows and average annual flows for the White River, near Watson , Utah. White River Geomorphic Assessment 21 of 99 Figure 8 – Daily discharge for White River near Watson, Utah for period 10 -2017 to 10 - 2018.Aerial photography used to complete this geomorphic assessment was taken on July 21, 2015, at a discharge of ~1780 cfs. METHODS STUDY AREAS We used four spatialextents for analys is in this study ,chosen asminimum areas to encompass each area of interest ( Figure 9). T he first is the entire White Riverwatershed, used to assess the riparian condition. The 2 nd extent includes the l ower White River fromKenney Reservoir to the confluence . A 3 rd extent includes the Utahportion to map valley geomorphic units ,and a 4th extentwas definedfor the study reaches within BLM managedland along the ri ver. For the latter extent, w e chose two adjoining sections of river for the purpose of studying geomorphic attributes and parameters in much greater detail than was done for the lower river,and explicitly for analyzing theseshorter reaches in the context of their valley margin and valley bottom margin geomorphic units.The upstream study area, BLM - A, is 33 km long, and the downstream study area, BLM -B is 20 km long. White River Geomorphic Assessment 22 of 99 Figure 9 – A reas of focus in this study: (1) the entire Lower White River watershed ; (2) fromKenney Reservoir to the mouth; ( 3) from Utah border to the mouth; ( 4 ) study reaches within BLM owned land . White River Geomorphic Assessment 23 of 99 RIVER CLASSIFICATION AND GEOMORPHIC CONDITIO N Reach Type Classification C ategorizing streams by theirgeomorphic attributes allows practitioners to understand and predict the form and function of streams across the diversity of landscapes within a single catchment . For this study , we use da reach type classification developed by Brierley and Fryirs (2005)that incorporates the valley setting(valley andchannel confinement) , floodplain extent, planform characteristics and where possible, bed m aterial ( Figure10 ). Reach types were determined for the lower White River downstream ofTaylor Draw Dam to the confluence of the Green River. The method relies on the interpreta tions and documentationof a trained geomorphologist who visually determines diagnostic geomorphic features using remote sensing techniques to delineate reachtypes (and verification by field work — see final section Recommended Future Work ) . In this study, we placed added emphasis on geomorphic indicators that are measured directly from air photos and rendered in GIS,and turned focus to only themains tem White River, and morespecifically, downstream of theUtah border.For more information and background onhow this technique was appliedelsewhere, the reader is referred to(Bennett et al., 2018; O'Brien and Wheaton, 2015; O’Brien et al., 2017) . The basis for geomorphic river classification is the systematic categorization of physical attributes of a river flowing in its channel, the valley through which it flows, and the geomorphic features that comprise its floodplain and channel (Buffington and Montgomery, 2013) .Through a spectrum of bedrock and alluvial variants, thesecharacteristics reflect a balance of sediment supply andchannel transport capacity. A river’s character (or form) is its unique rive r morphology, including valley, floodplain and instream geomorphic features. R iver behavior (or function) is the tendency and capacity for adjustment within its valley settingand floodplain, tied to boundary conditions set by flow and sediment fluxes typi cal for that stream. River behavior drives the assembly of geomorphic units present within its channel by form and process associations. Alongthe lowerWhite River, we identifiednine distinct reach types incorporating the attributes shown inFigure 10 . White River Geomorphic Assessment 24 of 99 Figure 10 – Procedural tree for reach types delineated in the White River watershed(note: this is not a dichotomous key; each top category simplyincludes the features below it or not). Valley Setting and Channel Confinement T he valley setting comprises the valley walls, valley landforms, floodplain (if present), and the channel. Potential confining margins are definedby the valley marginor valley bottom margin. Channel confinement is a measure of the ability of a channel to adjust laterally across its floodplain and between valley walls(Fryirs et al., 2016) .In this study, c onfinement is measured asthe percentage of channel along a predetermined interval (500 meters) that is in physical contact with a confining margin (also see Table1 and Figure 11 for more information) . The calculation of forms of confinement outlined inFryirs et al. (2016) (valley confinement and valley bottom confinement in this study ) take the formof : Equation 1  =     @         × 100 where  is confinement (between 0 and 100%),      is the sum total centerline length of channel over the distance that the channel margin along either bank abuts a confining margin (@ CM ), and   is the total centerline length of a channel segment under consideration. It is important to note that the measure of   @  does not double - count where the channel is confined along both banks and overlaps, which is a measure of constriction ; see Fryir s et al. (2016). Also note that we usethe term segment as a nounto describe the portion of the network polyline being analyzed, and not as a proxy for a river reach defined by geomorphiccharacteristics (Fausch etal., 2002) ( Figure 11 ) . Confinement is a dimensionless quantity, but its value is sensitive to the river reach length (   ) over which it is White River Geomorphic Assessment 25 of 99 calculated. The input quantities    @   and   are straightforward to measure manually off maps or imagery of sufficient resolutionand detail(as was done in this study) , or in the field for a single riv er reach . Confining margins are the borders of the valley itself, or themargin along valley bottom landforms that are not part of the valley walls, but impose a potential confining margin (i.e., potential contact with the valley or valley landforms ) for the channel . These intra -valley landforms are predominantly alluvial fans, andriver terraces in the White River watershed. Valley setting is the entry point for defining reach types, which in turn lead to understanding riparian domains and aquatic habitat .Throughout the report we refer to the following breaks to distinguish between confinements, which in turn are used to define river reach types ( Figure 11 ): • Laterally unconfined channels are free toadjust across the floodplain. In low gradient, alluvial valleys of the White River, the channel planformvaries between meandering (sinuosity 1.3 o r greater) and low sinuosity. Unconfined channels have contact with a confining margin10% or less along their length (Figure 18 and Figure 19 ). • P artly confined “planform- controlled” is a channel planform that is mostly free to wander or adjust laterally, but is imposed by confining a margin along 10 - 50% of its length ( Figure 22and Figure 23 ). • P artly confined, “margin- controlled” is a channel pattern whereconfinement is sustained along 50 -85% of its length, and tends to sweep alternately and smoothlybetween opposite banks (Figure 25 ). • Confined along 85 - 100% of its length,either on one bank, ora combination ofboth banks. In the White River, confined reaches are often insustained contact with sweeping turns of the bedrock walls (see next section for discussion of reach types and their conditions) (Figure 28and Figure 29 ). • Constricted, confined explicitlyby both banks along some interval ( Figure 33 ). For most of its length, the lower White River channel confinement ranges from laterally confined to partly confined ( Figure 1 and Figure 18 ). Figure 11 – Schematic of valley settings identified in this report (alsosee Table 1). White River Geomorphic Assessment 26 of 99 Geomorphic Condition Background and need for geomorphic condition assessment Individual reach types display channel/floodplain morphology resulting from hydrologic and sediment regimes driven by overarching catchment controls (e.g., Lane, 1955) . When fed by reasonably constant fluxes, they build and adjust to recognizable forms. However, waves ofdisturbance (either natural or anthropogenic) can affect the geomorphic condition of individual reaches or even entirewatersheds. Condition is measured (or recognized) bycomparison with and departure from, a “standard” or idealized reach type (either existing in the watershed or extrapolated) that represents the hydrologic, sedimentologic, and geologic/geomorphic conditions typical of that reach type (for example, a meandering river in a low -gradient, unconfined valley, versus a high gradient, confinedriver with stepped, coarse bed forms)(Fryirs, 2015). We measured geomorphiccondition in the lowerWhite River mostly with respect to (a) human development, and (b) consideration of “geoindicators”, which arethe attributes of every reach type that can be affected by disturbance and provide indication of that disturbance (Table 2 andFigure 12 ). River adjustment potential Geomorphic condition alsodepends to a large extent on a river’s capacity for adjustment , which isessentially a river’s ability to incur modifications of the floodplain, channel, and bed material characteristics controlled by the valley through which the river flows, the bedrock lithology and channel slope, and the sediment - discharge balance in the watershed. The adjustment potential of astream is a gauge of its sensitivity to local and system -widedisturbances in the watershed. For exampl e, Figure12 shows a cartoon of two conceptual valley settings found in the White River. The confined valley reach type ( atleft) has very low capacity for adjustment and is considered resistant to disturbance. The moderately sinuous gravel bed reach type (schematic at right) has significant adjustment potential and is sensitive/susceptible to direct and indirect disturbancesto its channel and floodplain. Such a valley invites settlement and development s uch as farming or industry owing to buildingspace, level surface s,fertile soil, and easy access to water. The confinedvalley river is able to incise or aggrade its bed, but its channel is laterally restricted by intervening bedrock, leaving only the arr angement of coarse bed material as a mode of adjustment. Reach types of laterally unconfined and partly -confined valley settings, on the otherhand, have moderate tohigh adjustment potential because their broad, fine - grained floodplains promote dynamically shifting meandering planforms. White River Geomorphic Assessment 27 of 99 Figure 12 – Confinement depicted for a confined and unconfined valley settings (fromO'Brien and Wheaton (20 15) . The diagram on theleft has little or no adjustment potential, whereas the diagram on the right possesses very high lateral and even vertical adjustmentpotential . Arrows indicate the vertical and lateral adjustment possible for each valley setting . Procedure for assessing geomorphic condition The following steps outline how geomorphic condition was documented for the lower White River.Table 2 li sts the crite ria used to evaluate and identify condition variants for each reach type. 1. Con duct the reach type assessment — understand and tabulate thecapacityfor adjustment and relevant geoindicators applicable to each ; 2. Sort and group instances of each reach type in the study area s;find the optimal condition standard and identify other condition variants ; 3. Identify and tabulate the appropriate geoindicators for each reach type, based on criteria in Table 2 ; 4. Look for deviations from the standard bestcondition reach and identify the affected geoindicators ; 5. Build tables that explain the geomorphic condition of each reach type and their variants; identify problem areas and those which are functioning normally. White River Geomorphic Assessment 28 of 99 Table 2.Criteria used to evaluate geo - indicators in this study . Geo- indicator Used in White River Evaluation key Channel/Floodplain Attributes SizeYes Consistent width throughout measured and observed reaches Shape No – need ground data Cross section Bank Yes Consistent with reach types Floodplain connectivity Yes Active proximity to channel, presence/absence of incision Floodplain types (none, occasional FP pockets, discontinuous, continuous) Yes H ealthy riparian condition, morphology consistent with adjusting floodplain Instream vegetation structure Yes, where o bserved Presence/absence Instream wood recruitment Yes, where observed Presence/absence Channel Planform Valley Bottom Confinement - GNAT Confinement Tool Ran tool for whole river confinement and BLM study reach B Output matches a cross check , usually light editing required Braiding index/Number of channels Yes Active anabranching consistent with valley morphology and forcing mechanisms. Planform sinuosity Manually measured in GIS for BLM study reaches Consistent per reach type Valley sinuosity Yes, measured for Utah reach Reported average ratio 1.5 Sinuosity of channels Yes, for BLM study reaches Consistent per confinement V alley confining margin (fans/terraces)Yes, mapped for Utah portion Visual reconnaissance mapping using high -resolution air photos and GIS Lateral stability No, but is consistent with reach types
https://www.researchgate.net/publication/331135591_Geomorphic_Assessment_of_the_Lower_White_River_Valley_Landform_Delineation_Reach_Typing_and_Geomorphic_Condition_Assessment