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Mar 11

EventDance: Unsupervised Source-free Cross-modal Adaptation for Event-based Object Recognition

In this paper, we make the first attempt at achieving the cross-modal (i.e., image-to-events) adaptation for event-based object recognition without accessing any labeled source image data owning to privacy and commercial issues. Tackling this novel problem is non-trivial due to the novelty of event cameras and the distinct modality gap between images and events. In particular, as only the source model is available, a hurdle is how to extract the knowledge from the source model by only using the unlabeled target event data while achieving knowledge transfer. To this end, we propose a novel framework, dubbed EventDance for this unsupervised source-free cross-modal adaptation problem. Importantly, inspired by event-to-video reconstruction methods, we propose a reconstruction-based modality bridging (RMB) module, which reconstructs intensity frames from events in a self-supervised manner. This makes it possible to build up the surrogate images to extract the knowledge (i.e., labels) from the source model. We then propose a multi-representation knowledge adaptation (MKA) module that transfers the knowledge to target models learning events with multiple representation types for fully exploring the spatiotemporal information of events. The two modules connecting the source and target models are mutually updated so as to achieve the best performance. Experiments on three benchmark datasets with two adaption settings show that EventDance is on par with prior methods utilizing the source data.

Towards Effective and Sparse Adversarial Attack on Spiking Neural Networks via Breaking Invisible Surrogate Gradients

Spiking neural networks (SNNs) have shown their competence in handling spatial-temporal event-based data with low energy consumption. Similar to conventional artificial neural networks (ANNs), SNNs are also vulnerable to gradient-based adversarial attacks, wherein gradients are calculated by spatial-temporal back-propagation (STBP) and surrogate gradients (SGs). However, the SGs may be invisible for an inference-only model as they do not influence the inference results, and current gradient-based attacks are ineffective for binary dynamic images captured by the dynamic vision sensor (DVS). While some approaches addressed the issue of invisible SGs through universal SGs, their SGs lack a correlation with the victim model, resulting in sub-optimal performance. Moreover, the imperceptibility of existing SNN-based binary attacks is still insufficient. In this paper, we introduce an innovative potential-dependent surrogate gradient (PDSG) method to establish a robust connection between the SG and the model, thereby enhancing the adaptability of adversarial attacks across various models with invisible SGs. Additionally, we propose the sparse dynamic attack (SDA) to effectively attack binary dynamic images. Utilizing a generation-reduction paradigm, SDA can fully optimize the sparsity of adversarial perturbations. Experimental results demonstrate that our PDSG and SDA outperform state-of-the-art SNN-based attacks across various models and datasets. Specifically, our PDSG achieves 100% attack success rate on ImageNet, and our SDA obtains 82% attack success rate by modifying only 0.24% of the pixels on CIFAR10DVS. The code is available at https://github.com/ryime/PDSG-SDA .

SpaRP: Fast 3D Object Reconstruction and Pose Estimation from Sparse Views

Open-world 3D generation has recently attracted considerable attention. While many single-image-to-3D methods have yielded visually appealing outcomes, they often lack sufficient controllability and tend to produce hallucinated regions that may not align with users' expectations. In this paper, we explore an important scenario in which the input consists of one or a few unposed 2D images of a single object, with little or no overlap. We propose a novel method, SpaRP, to reconstruct a 3D textured mesh and estimate the relative camera poses for these sparse-view images. SpaRP distills knowledge from 2D diffusion models and finetunes them to implicitly deduce the 3D spatial relationships between the sparse views. The diffusion model is trained to jointly predict surrogate representations for camera poses and multi-view images of the object under known poses, integrating all information from the input sparse views. These predictions are then leveraged to accomplish 3D reconstruction and pose estimation, and the reconstructed 3D model can be used to further refine the camera poses of input views. Through extensive experiments on three datasets, we demonstrate that our method not only significantly outperforms baseline methods in terms of 3D reconstruction quality and pose prediction accuracy but also exhibits strong efficiency. It requires only about 20 seconds to produce a textured mesh and camera poses for the input views. Project page: https://chaoxu.xyz/sparp.

Semi-Parametric Neural Image Synthesis

Novel architectures have recently improved generative image synthesis leading to excellent visual quality in various tasks. Much of this success is due to the scalability of these architectures and hence caused by a dramatic increase in model complexity and in the computational resources invested in training these models. Our work questions the underlying paradigm of compressing large training data into ever growing parametric representations. We rather present an orthogonal, semi-parametric approach. We complement comparably small diffusion or autoregressive models with a separate image database and a retrieval strategy. During training we retrieve a set of nearest neighbors from this external database for each training instance and condition the generative model on these informative samples. While the retrieval approach is providing the (local) content, the model is focusing on learning the composition of scenes based on this content. As demonstrated by our experiments, simply swapping the database for one with different contents transfers a trained model post-hoc to a novel domain. The evaluation shows competitive performance on tasks which the generative model has not been trained on, such as class-conditional synthesis, zero-shot stylization or text-to-image synthesis without requiring paired text-image data. With negligible memory and computational overhead for the external database and retrieval we can significantly reduce the parameter count of the generative model and still outperform the state-of-the-art.

DreamCreature: Crafting Photorealistic Virtual Creatures from Imagination

Recent text-to-image (T2I) generative models allow for high-quality synthesis following either text instructions or visual examples. Despite their capabilities, these models face limitations in creating new, detailed creatures within specific categories (e.g., virtual dog or bird species), which are valuable in digital asset creation and biodiversity analysis. To bridge this gap, we introduce a novel task, Virtual Creatures Generation: Given a set of unlabeled images of the target concepts (e.g., 200 bird species), we aim to train a T2I model capable of creating new, hybrid concepts within diverse backgrounds and contexts. We propose a new method called DreamCreature, which identifies and extracts the underlying sub-concepts (e.g., body parts of a specific species) in an unsupervised manner. The T2I thus adapts to generate novel concepts (e.g., new bird species) with faithful structures and photorealistic appearance by seamlessly and flexibly composing learned sub-concepts. To enhance sub-concept fidelity and disentanglement, we extend the textual inversion technique by incorporating an additional projector and tailored attention loss regularization. Extensive experiments on two fine-grained image benchmarks demonstrate the superiority of DreamCreature over prior methods in both qualitative and quantitative evaluation. Ultimately, the learned sub-concepts facilitate diverse creative applications, including innovative consumer product designs and nuanced property modifications.

When Synthetic Traces Hide Real Content: Analysis of Stable Diffusion Image Laundering

In recent years, methods for producing highly realistic synthetic images have significantly advanced, allowing the creation of high-quality images from text prompts that describe the desired content. Even more impressively, Stable Diffusion (SD) models now provide users with the option of creating synthetic images in an image-to-image translation fashion, modifying images in the latent space of advanced autoencoders. This striking evolution, however, brings an alarming consequence: it is possible to pass an image through SD autoencoders to reproduce a synthetic copy of the image with high realism and almost no visual artifacts. This process, known as SD image laundering, can transform real images into lookalike synthetic ones and risks complicating forensic analysis for content authenticity verification. Our paper investigates the forensic implications of image laundering, revealing a serious potential to obscure traces of real content, including sensitive and harmful materials that could be mistakenly classified as synthetic, thereby undermining the protection of individuals depicted. To address this issue, we propose a two-stage detection pipeline that effectively differentiates between pristine, laundered, and fully synthetic images (those generated from text prompts), showing robustness across various conditions. Finally, we highlight another alarming property of image laundering, which appears to mask the unique artifacts exploited by forensic detectors to solve the camera model identification task, strongly undermining their performance. Our experimental code is available at https://github.com/polimi-ispl/synthetic-image-detection.

ImagiNet: A Multi-Content Dataset for Generalizable Synthetic Image Detection via Contrastive Learning

Generative models, such as diffusion models (DMs), variational autoencoders (VAEs), and generative adversarial networks (GANs), produce images with a level of authenticity that makes them nearly indistinguishable from real photos and artwork. While this capability is beneficial for many industries, the difficulty of identifying synthetic images leaves online media platforms vulnerable to impersonation and misinformation attempts. To support the development of defensive methods, we introduce ImagiNet, a high-resolution and balanced dataset for synthetic image detection, designed to mitigate potential biases in existing resources. It contains 200K examples, spanning four content categories: photos, paintings, faces, and uncategorized. Synthetic images are produced with open-source and proprietary generators, whereas real counterparts of the same content type are collected from public datasets. The structure of ImagiNet allows for a two-track evaluation system: i) classification as real or synthetic and ii) identification of the generative model. To establish a baseline, we train a ResNet-50 model using a self-supervised contrastive objective (SelfCon) for each track. The model demonstrates state-of-the-art performance and high inference speed across established benchmarks, achieving an AUC of up to 0.99 and balanced accuracy ranging from 86% to 95%, even under social network conditions that involve compression and resizing. Our data and code are available at https://github.com/delyan-boychev/imaginet.

A for-loop is all you need. For solving the inverse problem in the case of personalized tumor growth modeling

Solving the inverse problem is the key step in evaluating the capacity of a physical model to describe real phenomena. In medical image computing, it aligns with the classical theme of image-based model personalization. Traditionally, a solution to the problem is obtained by performing either sampling or variational inference based methods. Both approaches aim to identify a set of free physical model parameters that results in a simulation best matching an empirical observation. When applied to brain tumor modeling, one of the instances of image-based model personalization in medical image computing, the overarching drawback of the methods is the time complexity for finding such a set. In a clinical setting with limited time between imaging and diagnosis or even intervention, this time complexity may prove critical. As the history of quantitative science is the history of compression, we align in this paper with the historical tendency and propose a method compressing complex traditional strategies for solving an inverse problem into a simple database query task. We evaluated different ways of performing the database query task assessing the trade-off between accuracy and execution time. On the exemplary task of brain tumor growth modeling, we prove that the proposed method achieves one order speed-up compared to existing approaches for solving the inverse problem. The resulting compute time offers critical means for relying on more complex and, hence, realistic models, for integrating image preprocessing and inverse modeling even deeper, or for implementing the current model into a clinical workflow.

KITTEN: A Knowledge-Intensive Evaluation of Image Generation on Visual Entities

Recent advancements in text-to-image generation have significantly enhanced the quality of synthesized images. Despite this progress, evaluations predominantly focus on aesthetic appeal or alignment with text prompts. Consequently, there is limited understanding of whether these models can accurately represent a wide variety of realistic visual entities - a task requiring real-world knowledge. To address this gap, we propose a benchmark focused on evaluating Knowledge-InTensive image generaTion on real-world ENtities (i.e., KITTEN). Using KITTEN, we conduct a systematic study on the fidelity of entities in text-to-image generation models, focusing on their ability to generate a wide range of real-world visual entities, such as landmark buildings, aircraft, plants, and animals. We evaluate the latest text-to-image models and retrieval-augmented customization models using both automatic metrics and carefully-designed human evaluations, with an emphasis on the fidelity of entities in the generated images. Our findings reveal that even the most advanced text-to-image models often fail to generate entities with accurate visual details. Although retrieval-augmented models can enhance the fidelity of entity by incorporating reference images during testing, they often over-rely on these references and struggle to produce novel configurations of the entity as requested in creative text prompts.

MedImageInsight: An Open-Source Embedding Model for General Domain Medical Imaging

In this work, we present MedImageInsight, an open-source medical imaging embedding model. MedImageInsight is trained on medical images with associated text and labels across a diverse collection of domains, including X-Ray, CT, MRI, dermoscopy, OCT, fundus photography, ultrasound, histopathology, and mammography. Rigorous evaluations demonstrate MedImageInsight's ability to achieve state-of-the-art (SOTA) or human expert level performance across classification, image-image search, and fine-tuning tasks. Specifically, on public datasets, MedImageInsight achieves SOTA in CT 3D medical image retrieval, as well as SOTA in disease classification and search for chest X-ray, dermatology, and OCT imaging. Furthermore, MedImageInsight achieves human expert performance in bone age estimation (on both public and partner data), as well as AUC above 0.9 in most other domains. When paired with a text decoder, MedImageInsight achieves near SOTA level single image report findings generation with less than 10\% the parameters of other models. Compared to fine-tuning GPT-4o with only MIMIC-CXR data for the same task, MedImageInsight outperforms in clinical metrics, but underperforms on lexical metrics where GPT-4o sets a new SOTA. Importantly for regulatory purposes, MedImageInsight can generate ROC curves, adjust sensitivity and specificity based on clinical need, and provide evidence-based decision support through image-image search (which can also enable retrieval augmented generation). In an independent clinical evaluation of image-image search in chest X-ray, MedImageInsight outperformed every other publicly available foundation model evaluated by large margins (over 6 points AUC), and significantly outperformed other models in terms of AI fairness (across age and gender). We hope releasing MedImageInsight will help enhance collective progress in medical imaging AI research and development.

Efficient and Transferable Adversarial Examples from Bayesian Neural Networks

An established way to improve the transferability of black-box evasion attacks is to craft the adversarial examples on an ensemble-based surrogate to increase diversity. We argue that transferability is fundamentally related to uncertainty. Based on a state-of-the-art Bayesian Deep Learning technique, we propose a new method to efficiently build a surrogate by sampling approximately from the posterior distribution of neural network weights, which represents the belief about the value of each parameter. Our extensive experiments on ImageNet, CIFAR-10 and MNIST show that our approach improves the success rates of four state-of-the-art attacks significantly (up to 83.2 percentage points), in both intra-architecture and inter-architecture transferability. On ImageNet, our approach can reach 94% of success rate while reducing training computations from 11.6 to 2.4 exaflops, compared to an ensemble of independently trained DNNs. Our vanilla surrogate achieves 87.5% of the time higher transferability than three test-time techniques designed for this purpose. Our work demonstrates that the way to train a surrogate has been overlooked, although it is an important element of transfer-based attacks. We are, therefore, the first to review the effectiveness of several training methods in increasing transferability. We provide new directions to better understand the transferability phenomenon and offer a simple but strong baseline for future work.

Long-Term Photometric Consistent Novel View Synthesis with Diffusion Models

Novel view synthesis from a single input image is a challenging task, where the goal is to generate a new view of a scene from a desired camera pose that may be separated by a large motion. The highly uncertain nature of this synthesis task due to unobserved elements within the scene (i.e. occlusion) and outside the field-of-view makes the use of generative models appealing to capture the variety of possible outputs. In this paper, we propose a novel generative model capable of producing a sequence of photorealistic images consistent with a specified camera trajectory, and a single starting image. Our approach is centred on an autoregressive conditional diffusion-based model capable of interpolating visible scene elements, and extrapolating unobserved regions in a view, in a geometrically consistent manner. Conditioning is limited to an image capturing a single camera view and the (relative) pose of the new camera view. To measure the consistency over a sequence of generated views, we introduce a new metric, the thresholded symmetric epipolar distance (TSED), to measure the number of consistent frame pairs in a sequence. While previous methods have been shown to produce high quality images and consistent semantics across pairs of views, we show empirically with our metric that they are often inconsistent with the desired camera poses. In contrast, we demonstrate that our method produces both photorealistic and view-consistent imagery.

Pixel-Aware Stable Diffusion for Realistic Image Super-resolution and Personalized Stylization

Realistic image super-resolution (Real-ISR) aims to reproduce perceptually realistic image details from a low-quality input. The commonly used adversarial training based Real-ISR methods often introduce unnatural visual artifacts and fail to generate realistic textures for natural scene images. The recently developed generative stable diffusion models provide a potential solution to Real-ISR with pre-learned strong image priors. However, the existing methods along this line either fail to keep faithful pixel-wise image structures or resort to extra skipped connections to reproduce details, which requires additional training in image space and limits their extension to other related tasks in latent space such as image stylization. In this work, we propose a pixel-aware stable diffusion (PASD) network to achieve robust Real-ISR as well as personalized stylization. In specific, a pixel-aware cross attention module is introduced to enable diffusion models perceiving image local structures in pixel-wise level, while a degradation removal module is used to extract degradation insensitive features to guide the diffusion process together with image high level information. By simply replacing the base diffusion model with a personalized one, our method can generate diverse stylized images without the need to collect pairwise training data. PASD can be easily integrated into existing diffusion models such as Stable Diffusion. Experiments on Real-ISR and personalized stylization demonstrate the effectiveness of our proposed approach. The source code and models can be found at https://github.com/yangxy/PASD.

Boosting EfficientNets Ensemble Performance via Pseudo-Labels and Synthetic Images by pix2pixHD for Infection and Ischaemia Classification in Diabetic Foot Ulcers

Diabetic foot ulcers are a common manifestation of lesions on the diabetic foot, a syndrome acquired as a long-term complication of diabetes mellitus. Accompanying neuropathy and vascular damage promote acquisition of pressure injuries and tissue death due to ischaemia. Affected areas are prone to infections, hindering the healing progress. The research at hand investigates an approach on classification of infection and ischaemia, conducted as part of the Diabetic Foot Ulcer Challenge (DFUC) 2021. Different models of the EfficientNet family are utilized in ensembles. An extension strategy for the training data is applied, involving pseudo-labeling for unlabeled images, and extensive generation of synthetic images via pix2pixHD to cope with severe class imbalances. The resulting extended training dataset features 8.68 times the size of the baseline and shows a real to synthetic image ratio of 1:3. Performances of models and ensembles trained on the baseline and extended training dataset are compared. Synthetic images featured a broad qualitative variety. Results show that models trained on the extended training dataset as well as their ensemble benefit from the large extension. F1-Scores for rare classes receive outstanding boosts, while those for common classes are either not harmed or boosted moderately. A critical discussion concretizes benefits and identifies limitations, suggesting improvements. The work concludes that classification performance of individual models as well as that of ensembles can be boosted utilizing synthetic images. Especially performance for rare classes benefits notably.

Re-Thinking Inverse Graphics With Large Language Models

Inverse graphics -- the task of inverting an image into physical variables that, when rendered, enable reproduction of the observed scene -- is a fundamental challenge in computer vision and graphics. Disentangling an image into its constituent elements, such as the shape, color, and material properties of the objects of the 3D scene that produced it, requires a comprehensive understanding of the environment. This requirement limits the ability of existing carefully engineered approaches to generalize across domains. Inspired by the zero-shot ability of large language models (LLMs) to generalize to novel contexts, we investigate the possibility of leveraging the broad world knowledge encoded in such models in solving inverse-graphics problems. To this end, we propose the Inverse-Graphics Large Language Model (IG-LLM), an inverse-graphics framework centered around an LLM, that autoregressively decodes a visual embedding into a structured, compositional 3D-scene representation. We incorporate a frozen pre-trained visual encoder and a continuous numeric head to enable end-to-end training. Through our investigation, we demonstrate the potential of LLMs to facilitate inverse graphics through next-token prediction, without the use of image-space supervision. Our analysis opens up new possibilities for precise spatial reasoning about images that exploit the visual knowledge of LLMs. We will release our code and data to ensure the reproducibility of our investigation and to facilitate future research at https://ig-llm.is.tue.mpg.de/

RAP-SR: RestorAtion Prior Enhancement in Diffusion Models for Realistic Image Super-Resolution

Benefiting from their powerful generative capabilities, pretrained diffusion models have garnered significant attention for real-world image super-resolution (Real-SR). Existing diffusion-based SR approaches typically utilize semantic information from degraded images and restoration prompts to activate prior for producing realistic high-resolution images. However, general-purpose pretrained diffusion models, not designed for restoration tasks, often have suboptimal prior, and manually defined prompts may fail to fully exploit the generated potential. To address these limitations, we introduce RAP-SR, a novel restoration prior enhancement approach in pretrained diffusion models for Real-SR. First, we develop the High-Fidelity Aesthetic Image Dataset (HFAID), curated through a Quality-Driven Aesthetic Image Selection Pipeline (QDAISP). Our dataset not only surpasses existing ones in fidelity but also excels in aesthetic quality. Second, we propose the Restoration Priors Enhancement Framework, which includes Restoration Priors Refinement (RPR) and Restoration-Oriented Prompt Optimization (ROPO) modules. RPR refines the restoration prior using the HFAID, while ROPO optimizes the unique restoration identifier, improving the quality of the resulting images. RAP-SR effectively bridges the gap between general-purpose models and the demands of Real-SR by enhancing restoration prior. Leveraging the plug-and-play nature of RAP-SR, our approach can be seamlessly integrated into existing diffusion-based SR methods, boosting their performance. Extensive experiments demonstrate its broad applicability and state-of-the-art results. Codes and datasets will be available upon acceptance.

VITON-HD: High-Resolution Virtual Try-On via Misalignment-Aware Normalization

The task of image-based virtual try-on aims to transfer a target clothing item onto the corresponding region of a person, which is commonly tackled by fitting the item to the desired body part and fusing the warped item with the person. While an increasing number of studies have been conducted, the resolution of synthesized images is still limited to low (e.g., 256x192), which acts as the critical limitation against satisfying online consumers. We argue that the limitation stems from several challenges: as the resolution increases, the artifacts in the misaligned areas between the warped clothes and the desired clothing regions become noticeable in the final results; the architectures used in existing methods have low performance in generating high-quality body parts and maintaining the texture sharpness of the clothes. To address the challenges, we propose a novel virtual try-on method called VITON-HD that successfully synthesizes 1024x768 virtual try-on images. Specifically, we first prepare the segmentation map to guide our virtual try-on synthesis, and then roughly fit the target clothing item to a given person's body. Next, we propose ALIgnment-Aware Segment (ALIAS) normalization and ALIAS generator to handle the misaligned areas and preserve the details of 1024x768 inputs. Through rigorous comparison with existing methods, we demonstrate that VITON-HD highly surpasses the baselines in terms of synthesized image quality both qualitatively and quantitatively. Code is available at https://github.com/shadow2496/VITON-HD.

A Comprehensive Study of GPT-4V's Multimodal Capabilities in Medical Imaging

This paper presents a comprehensive evaluation of GPT-4V's capabilities across diverse medical imaging tasks, including Radiology Report Generation, Medical Visual Question Answering (VQA), and Visual Grounding. While prior efforts have explored GPT-4V's performance in medical image analysis, to the best of our knowledge, our study represents the first quantitative evaluation on publicly available benchmarks. Our findings highlight GPT-4V's potential in generating descriptive reports for chest X-ray images, particularly when guided by well-structured prompts. Meanwhile, its performance on the MIMIC-CXR dataset benchmark reveals areas for improvement in certain evaluation metrics, such as CIDEr. In the domain of Medical VQA, GPT-4V demonstrates proficiency in distinguishing between question types but falls short of the VQA-RAD benchmark in terms of accuracy. Furthermore, our analysis finds the limitations of conventional evaluation metrics like the BLEU scores, advocating for the development of more semantically robust assessment methods. In the field of Visual Grounding, GPT-4V exhibits preliminary promise in recognizing bounding boxes, but its precision is lacking, especially in identifying specific medical organs and signs. Our evaluation underscores the significant potential of GPT-4V in the medical imaging domain, while also emphasizing the need for targeted refinements to fully unlock its capabilities.

QuantNAS for super resolution: searching for efficient quantization-friendly architectures against quantization noise

There is a constant need for high-performing and computationally efficient neural network models for image super-resolution: computationally efficient models can be used via low-capacity devices and reduce carbon footprints. One way to obtain such models is to compress models, e.g. quantization. Another way is a neural architecture search that automatically discovers new, more efficient solutions. We propose a novel quantization-aware procedure, the QuantNAS that combines pros of these two approaches. To make QuantNAS work, the procedure looks for quantization-friendly super-resolution models. The approach utilizes entropy regularization, quantization noise, and Adaptive Deviation for Quantization (ADQ) module to enhance the search procedure. The entropy regularization technique prioritizes a single operation within each block of the search space. Adding quantization noise to parameters and activations approximates model degradation after quantization, resulting in a more quantization-friendly architectures. ADQ helps to alleviate problems caused by Batch Norm blocks in super-resolution models. Our experimental results show that the proposed approximations are better for search procedure than direct model quantization. QuantNAS discovers architectures with better PSNR/BitOps trade-off than uniform or mixed precision quantization of fixed architectures. We showcase the effectiveness of our method through its application to two search spaces inspired by the state-of-the-art SR models and RFDN. Thus, anyone can design a proper search space based on an existing architecture and apply our method to obtain better quality and efficiency. The proposed procedure is 30\% faster than direct weight quantization and is more stable.

Improving Diffusion Models for Virtual Try-on

This paper considers image-based virtual try-on, which renders an image of a person wearing a curated garment, given a pair of images depicting the person and the garment, respectively. Previous works adapt existing exemplar-based inpainting diffusion models for virtual try-on to improve the naturalness of the generated visuals compared to other methods (e.g., GAN-based), but they fail to preserve the identity of the garments. To overcome this limitation, we propose a novel diffusion model that improves garment fidelity and generates authentic virtual try-on images. Our method, coined IDM-VTON, uses two different modules to encode the semantics of garment image; given the base UNet of the diffusion model, 1) the high-level semantics extracted from a visual encoder are fused to the cross-attention layer, and then 2) the low-level features extracted from parallel UNet are fused to the self-attention layer. In addition, we provide detailed textual prompts for both garment and person images to enhance the authenticity of the generated visuals. Finally, we present a customization method using a pair of person-garment images, which significantly improves fidelity and authenticity. Our experimental results show that our method outperforms previous approaches (both diffusion-based and GAN-based) in preserving garment details and generating authentic virtual try-on images, both qualitatively and quantitatively. Furthermore, the proposed customization method demonstrates its effectiveness in a real-world scenario.

DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation

Large text-to-image models achieved a remarkable leap in the evolution of AI, enabling high-quality and diverse synthesis of images from a given text prompt. However, these models lack the ability to mimic the appearance of subjects in a given reference set and synthesize novel renditions of them in different contexts. In this work, we present a new approach for "personalization" of text-to-image diffusion models (specializing them to users' needs). Given as input just a few images of a subject, we fine-tune a pretrained text-to-image model (Imagen, although our method is not limited to a specific model) such that it learns to bind a unique identifier with that specific subject. Once the subject is embedded in the output domain of the model, the unique identifier can then be used to synthesize fully-novel photorealistic images of the subject contextualized in different scenes. By leveraging the semantic prior embedded in the model with a new autogenous class-specific prior preservation loss, our technique enables synthesizing the subject in diverse scenes, poses, views, and lighting conditions that do not appear in the reference images. We apply our technique to several previously-unassailable tasks, including subject recontextualization, text-guided view synthesis, appearance modification, and artistic rendering (all while preserving the subject's key features). Project page: https://dreambooth.github.io/

RoentGen: Vision-Language Foundation Model for Chest X-ray Generation

Multimodal models trained on large natural image-text pair datasets have exhibited astounding abilities in generating high-quality images. Medical imaging data is fundamentally different to natural images, and the language used to succinctly capture relevant details in medical data uses a different, narrow but semantically rich, domain-specific vocabulary. Not surprisingly, multi-modal models trained on natural image-text pairs do not tend to generalize well to the medical domain. Developing generative imaging models faithfully representing medical concepts while providing compositional diversity could mitigate the existing paucity of high-quality, annotated medical imaging datasets. In this work, we develop a strategy to overcome the large natural-medical distributional shift by adapting a pre-trained latent diffusion model on a corpus of publicly available chest x-rays (CXR) and their corresponding radiology (text) reports. We investigate the model's ability to generate high-fidelity, diverse synthetic CXR conditioned on text prompts. We assess the model outputs quantitatively using image quality metrics, and evaluate image quality and text-image alignment by human domain experts. We present evidence that the resulting model (RoentGen) is able to create visually convincing, diverse synthetic CXR images, and that the output can be controlled to a new extent by using free-form text prompts including radiology-specific language. Fine-tuning this model on a fixed training set and using it as a data augmentation method, we measure a 5% improvement of a classifier trained jointly on synthetic and real images, and a 3% improvement when trained on a larger but purely synthetic training set. Finally, we observe that this fine-tuning distills in-domain knowledge in the text-encoder and can improve its representation capabilities of certain diseases like pneumothorax by 25%.

FashionR2R: Texture-preserving Rendered-to-Real Image Translation with Diffusion Models

Modeling and producing lifelike clothed human images has attracted researchers' attention from different areas for decades, with the complexity from highly articulated and structured content. Rendering algorithms decompose and simulate the imaging process of a camera, while are limited by the accuracy of modeled variables and the efficiency of computation. Generative models can produce impressively vivid human images, however still lacking in controllability and editability. This paper studies photorealism enhancement of rendered images, leveraging generative power from diffusion models on the controlled basis of rendering. We introduce a novel framework to translate rendered images into their realistic counterparts, which consists of two stages: Domain Knowledge Injection (DKI) and Realistic Image Generation (RIG). In DKI, we adopt positive (real) domain finetuning and negative (rendered) domain embedding to inject knowledge into a pretrained Text-to-image (T2I) diffusion model. In RIG, we generate the realistic image corresponding to the input rendered image, with a Texture-preserving Attention Control (TAC) to preserve fine-grained clothing textures, exploiting the decoupled features encoded in the UNet structure. Additionally, we introduce SynFashion dataset, featuring high-quality digital clothing images with diverse textures. Extensive experimental results demonstrate the superiority and effectiveness of our method in rendered-to-real image translation.

CustomContrast: A Multilevel Contrastive Perspective For Subject-Driven Text-to-Image Customization

Subject-driven text-to-image (T2I) customization has drawn significant interest in academia and industry. This task enables pre-trained models to generate novel images based on unique subjects. Existing studies adopt a self-reconstructive perspective, focusing on capturing all details of a single image, which will misconstrue the specific image's irrelevant attributes (e.g., view, pose, and background) as the subject intrinsic attributes. This misconstruction leads to both overfitting or underfitting of irrelevant and intrinsic attributes of the subject, i.e., these attributes are over-represented or under-represented simultaneously, causing a trade-off between similarity and controllability. In this study, we argue an ideal subject representation can be achieved by a cross-differential perspective, i.e., decoupling subject intrinsic attributes from irrelevant attributes via contrastive learning, which allows the model to focus more on intrinsic attributes through intra-consistency (features of the same subject are spatially closer) and inter-distinctiveness (features of different subjects have distinguished differences). Specifically, we propose CustomContrast, a novel framework, which includes a Multilevel Contrastive Learning (MCL) paradigm and a Multimodal Feature Injection (MFI) Encoder. The MCL paradigm is used to extract intrinsic features of subjects from high-level semantics to low-level appearance through crossmodal semantic contrastive learning and multiscale appearance contrastive learning. To facilitate contrastive learning, we introduce the MFI encoder to capture cross-modal representations. Extensive experiments show the effectiveness of CustomContrast in subject similarity and text controllability.

PhotoVerse: Tuning-Free Image Customization with Text-to-Image Diffusion Models

Personalized text-to-image generation has emerged as a powerful and sought-after tool, empowering users to create customized images based on their specific concepts and prompts. However, existing approaches to personalization encounter multiple challenges, including long tuning times, large storage requirements, the necessity for multiple input images per identity, and limitations in preserving identity and editability. To address these obstacles, we present PhotoVerse, an innovative methodology that incorporates a dual-branch conditioning mechanism in both text and image domains, providing effective control over the image generation process. Furthermore, we introduce facial identity loss as a novel component to enhance the preservation of identity during training. Remarkably, our proposed PhotoVerse eliminates the need for test time tuning and relies solely on a single facial photo of the target identity, significantly reducing the resource cost associated with image generation. After a single training phase, our approach enables generating high-quality images within only a few seconds. Moreover, our method can produce diverse images that encompass various scenes and styles. The extensive evaluation demonstrates the superior performance of our approach, which achieves the dual objectives of preserving identity and facilitating editability. Project page: https://photoverse2d.github.io/

Generative AI for Medical Imaging: extending the MONAI Framework

Recent advances in generative AI have brought incredible breakthroughs in several areas, including medical imaging. These generative models have tremendous potential not only to help safely share medical data via synthetic datasets but also to perform an array of diverse applications, such as anomaly detection, image-to-image translation, denoising, and MRI reconstruction. However, due to the complexity of these models, their implementation and reproducibility can be difficult. This complexity can hinder progress, act as a use barrier, and dissuade the comparison of new methods with existing works. In this study, we present MONAI Generative Models, a freely available open-source platform that allows researchers and developers to easily train, evaluate, and deploy generative models and related applications. Our platform reproduces state-of-art studies in a standardised way involving different architectures (such as diffusion models, autoregressive transformers, and GANs), and provides pre-trained models for the community. We have implemented these models in a generalisable fashion, illustrating that their results can be extended to 2D or 3D scenarios, including medical images with different modalities (like CT, MRI, and X-Ray data) and from different anatomical areas. Finally, we adopt a modular and extensible approach, ensuring long-term maintainability and the extension of current applications for future features.

Bridging the Gap: Studio-like Avatar Creation from a Monocular Phone Capture

Creating photorealistic avatars for individuals traditionally involves extensive capture sessions with complex and expensive studio devices like the LightStage system. While recent strides in neural representations have enabled the generation of photorealistic and animatable 3D avatars from quick phone scans, they have the capture-time lighting baked-in, lack facial details and have missing regions in areas such as the back of the ears. Thus, they lag in quality compared to studio-captured avatars. In this paper, we propose a method that bridges this gap by generating studio-like illuminated texture maps from short, monocular phone captures. We do this by parameterizing the phone texture maps using the W^+ space of a StyleGAN2, enabling near-perfect reconstruction. Then, we finetune a StyleGAN2 by sampling in the W^+ parameterized space using a very small set of studio-captured textures as an adversarial training signal. To further enhance the realism and accuracy of facial details, we super-resolve the output of the StyleGAN2 using carefully designed diffusion model that is guided by image gradients of the phone-captured texture map. Once trained, our method excels at producing studio-like facial texture maps from casual monocular smartphone videos. Demonstrating its capabilities, we showcase the generation of photorealistic, uniformly lit, complete avatars from monocular phone captures. http://shahrukhathar.github.io/2024/07/22/Bridging.html{The project page can be found here.}

The Brittleness of AI-Generated Image Watermarking Techniques: Examining Their Robustness Against Visual Paraphrasing Attacks

The rapid advancement of text-to-image generation systems, exemplified by models like Stable Diffusion, Midjourney, Imagen, and DALL-E, has heightened concerns about their potential misuse. In response, companies like Meta and Google have intensified their efforts to implement watermarking techniques on AI-generated images to curb the circulation of potentially misleading visuals. However, in this paper, we argue that current image watermarking methods are fragile and susceptible to being circumvented through visual paraphrase attacks. The proposed visual paraphraser operates in two steps. First, it generates a caption for the given image using KOSMOS-2, one of the latest state-of-the-art image captioning systems. Second, it passes both the original image and the generated caption to an image-to-image diffusion system. During the denoising step of the diffusion pipeline, the system generates a visually similar image that is guided by the text caption. The resulting image is a visual paraphrase and is free of any watermarks. Our empirical findings demonstrate that visual paraphrase attacks can effectively remove watermarks from images. This paper provides a critical assessment, empirically revealing the vulnerability of existing watermarking techniques to visual paraphrase attacks. While we do not propose solutions to this issue, this paper serves as a call to action for the scientific community to prioritize the development of more robust watermarking techniques. Our first-of-its-kind visual paraphrase dataset and accompanying code are publicly available.

Key-Locked Rank One Editing for Text-to-Image Personalization

Text-to-image models (T2I) offer a new level of flexibility by allowing users to guide the creative process through natural language. However, personalizing these models to align with user-provided visual concepts remains a challenging problem. The task of T2I personalization poses multiple hard challenges, such as maintaining high visual fidelity while allowing creative control, combining multiple personalized concepts in a single image, and keeping a small model size. We present Perfusion, a T2I personalization method that addresses these challenges using dynamic rank-1 updates to the underlying T2I model. Perfusion avoids overfitting by introducing a new mechanism that "locks" new concepts' cross-attention Keys to their superordinate category. Additionally, we develop a gated rank-1 approach that enables us to control the influence of a learned concept during inference time and to combine multiple concepts. This allows runtime-efficient balancing of visual-fidelity and textual-alignment with a single 100KB trained model, which is five orders of magnitude smaller than the current state of the art. Moreover, it can span different operating points across the Pareto front without additional training. Finally, we show that Perfusion outperforms strong baselines in both qualitative and quantitative terms. Importantly, key-locking leads to novel results compared to traditional approaches, allowing to portray personalized object interactions in unprecedented ways, even in one-shot settings.

Multi-view X-ray Image Synthesis with Multiple Domain Disentanglement from CT Scans

X-ray images play a vital role in the intraoperative processes due to their high resolution and fast imaging speed and greatly promote the subsequent segmentation, registration and reconstruction. However, over-dosed X-rays superimpose potential risks to human health to some extent. Data-driven algorithms from volume scans to X-ray images are restricted by the scarcity of paired X-ray and volume data. Existing methods are mainly realized by modelling the whole X-ray imaging procedure. In this study, we propose a learning-based approach termed CT2X-GAN to synthesize the X-ray images in an end-to-end manner using the content and style disentanglement from three different image domains. Our method decouples the anatomical structure information from CT scans and style information from unpaired real X-ray images/ digital reconstructed radiography (DRR) images via a series of decoupling encoders. Additionally, we introduce a novel consistency regularization term to improve the stylistic resemblance between synthesized X-ray images and real X-ray images. Meanwhile, we also impose a supervised process by computing the similarity of computed real DRR and synthesized DRR images. We further develop a pose attention module to fully strengthen the comprehensive information in the decoupled content code from CT scans, facilitating high-quality multi-view image synthesis in the lower 2D space. Extensive experiments were conducted on the publicly available CTSpine1K dataset and achieved 97.8350, 0.0842 and 3.0938 in terms of FID, KID and defined user-scored X-ray similarity, respectively. In comparison with 3D-aware methods (pi-GAN, EG3D), CT2X-GAN is superior in improving the synthesis quality and realistic to the real X-ray images.

Visual Lexicon: Rich Image Features in Language Space

We present Visual Lexicon, a novel visual language that encodes rich image information into the text space of vocabulary tokens while retaining intricate visual details that are often challenging to convey in natural language. Unlike traditional methods that prioritize either high-level semantics (e.g., CLIP) or pixel-level reconstruction (e.g., VAE), ViLex simultaneously captures rich semantic content and fine visual details, enabling high-quality image generation and comprehensive visual scene understanding. Through a self-supervised learning pipeline, ViLex generates tokens optimized for reconstructing input images using a frozen text-to-image (T2I) diffusion model, preserving the detailed information necessary for high-fidelity semantic-level reconstruction. As an image embedding in the language space, ViLex tokens leverage the compositionality of natural languages, allowing them to be used independently as "text tokens" or combined with natural language tokens to prompt pretrained T2I models with both visual and textual inputs, mirroring how we interact with vision-language models (VLMs). Experiments demonstrate that ViLex achieves higher fidelity in image reconstruction compared to text embeddings--even with a single ViLex token. Moreover, ViLex successfully performs various DreamBooth tasks in a zero-shot, unsupervised manner without fine-tuning T2I models. Additionally, ViLex serves as a powerful vision encoder, consistently improving vision-language model performance across 15 benchmarks relative to a strong SigLIP baseline.

Rethinking the Up-Sampling Operations in CNN-based Generative Network for Generalizable Deepfake Detection

Recently, the proliferation of highly realistic synthetic images, facilitated through a variety of GANs and Diffusions, has significantly heightened the susceptibility to misuse. While the primary focus of deepfake detection has traditionally centered on the design of detection algorithms, an investigative inquiry into the generator architectures has remained conspicuously absent in recent years. This paper contributes to this lacuna by rethinking the architectures of CNN-based generators, thereby establishing a generalized representation of synthetic artifacts. Our findings illuminate that the up-sampling operator can, beyond frequency-based artifacts, produce generalized forgery artifacts. In particular, the local interdependence among image pixels caused by upsampling operators is significantly demonstrated in synthetic images generated by GAN or diffusion. Building upon this observation, we introduce the concept of Neighboring Pixel Relationships(NPR) as a means to capture and characterize the generalized structural artifacts stemming from up-sampling operations. A comprehensive analysis is conducted on an open-world dataset, comprising samples generated by 28 distinct generative models. This analysis culminates in the establishment of a novel state-of-the-art performance, showcasing a remarkable 11.6\% improvement over existing methods. The code is available at https://github.com/chuangchuangtan/NPR-DeepfakeDetection.

Posterior-Mean Rectified Flow: Towards Minimum MSE Photo-Realistic Image Restoration

Photo-realistic image restoration algorithms are typically evaluated by distortion measures (e.g., PSNR, SSIM) and by perceptual quality measures (e.g., FID, NIQE), where the desire is to attain the lowest possible distortion without compromising on perceptual quality. To achieve this goal, current methods typically attempt to sample from the posterior distribution, or to optimize a weighted sum of a distortion loss (e.g., MSE) and a perceptual quality loss (e.g., GAN). Unlike previous works, this paper is concerned specifically with the optimal estimator that minimizes the MSE under a constraint of perfect perceptual index, namely where the distribution of the reconstructed images is equal to that of the ground-truth ones. A recent theoretical result shows that such an estimator can be constructed by optimally transporting the posterior mean prediction (MMSE estimate) to the distribution of the ground-truth images. Inspired by this result, we introduce Posterior-Mean Rectified Flow (PMRF), a simple yet highly effective algorithm that approximates this optimal estimator. In particular, PMRF first predicts the posterior mean, and then transports the result to a high-quality image using a rectified flow model that approximates the desired optimal transport map. We investigate the theoretical utility of PMRF and demonstrate that it consistently outperforms previous methods on a variety of image restoration tasks.

SingleInsert: Inserting New Concepts from a Single Image into Text-to-Image Models for Flexible Editing

Recent progress in text-to-image (T2I) models enables high-quality image generation with flexible textual control. To utilize the abundant visual priors in the off-the-shelf T2I models, a series of methods try to invert an image to proper embedding that aligns with the semantic space of the T2I model. However, these image-to-text (I2T) inversion methods typically need multiple source images containing the same concept or struggle with the imbalance between editing flexibility and visual fidelity. In this work, we point out that the critical problem lies in the foreground-background entanglement when learning an intended concept, and propose a simple and effective baseline for single-image I2T inversion, named SingleInsert. SingleInsert adopts a two-stage scheme. In the first stage, we regulate the learned embedding to concentrate on the foreground area without being associated with the irrelevant background. In the second stage, we finetune the T2I model for better visual resemblance and devise a semantic loss to prevent the language drift problem. With the proposed techniques, SingleInsert excels in single concept generation with high visual fidelity while allowing flexible editing. Additionally, SingleInsert can perform single-image novel view synthesis and multiple concepts composition without requiring joint training. To facilitate evaluation, we design an editing prompt list and introduce a metric named Editing Success Rate (ESR) for quantitative assessment of editing flexibility. Our project page is: https://jarrentwu1031.github.io/SingleInsert-web/

Learned representation-guided diffusion models for large-image generation

To synthesize high-fidelity samples, diffusion models typically require auxiliary data to guide the generation process. However, it is impractical to procure the painstaking patch-level annotation effort required in specialized domains like histopathology and satellite imagery; it is often performed by domain experts and involves hundreds of millions of patches. Modern-day self-supervised learning (SSL) representations encode rich semantic and visual information. In this paper, we posit that such representations are expressive enough to act as proxies to fine-grained human labels. We introduce a novel approach that trains diffusion models conditioned on embeddings from SSL. Our diffusion models successfully project these features back to high-quality histopathology and remote sensing images. In addition, we construct larger images by assembling spatially consistent patches inferred from SSL embeddings, preserving long-range dependencies. Augmenting real data by generating variations of real images improves downstream classifier accuracy for patch-level and larger, image-scale classification tasks. Our models are effective even on datasets not encountered during training, demonstrating their robustness and generalizability. Generating images from learned embeddings is agnostic to the source of the embeddings. The SSL embeddings used to generate a large image can either be extracted from a reference image, or sampled from an auxiliary model conditioned on any related modality (e.g. class labels, text, genomic data). As proof of concept, we introduce the text-to-large image synthesis paradigm where we successfully synthesize large pathology and satellite images out of text descriptions.

ConsisSR: Delving Deep into Consistency in Diffusion-based Image Super-Resolution

Real-world image super-resolution (Real-ISR) aims at restoring high-quality (HQ) images from low-quality (LQ) inputs corrupted by unknown and complex degradations. In particular, pretrained text-to-image (T2I) diffusion models provide strong generative priors to reconstruct credible and intricate details. However, T2I generation focuses on semantic consistency while Real-ISR emphasizes pixel-level reconstruction, which hinders existing methods from fully exploiting diffusion priors. To address this challenge, we introduce ConsisSR to handle both semantic and pixel-level consistency. Specifically, compared to coarse-grained text prompts, we exploit the more powerful CLIP image embedding and effectively leverage both modalities through our Hybrid Prompt Adapter (HPA) for semantic guidance. Secondly, we introduce Time-aware Latent Augmentation (TALA) to mitigate the inherent gap between T2I generation and Real-ISR consistency requirements. By randomly mixing LQ and HQ latent inputs, our model not only handle timestep-specific diffusion noise but also refine the accumulated latent representations. Last but not least, our GAN-Embedding strategy employs the pretrained Real-ESRGAN model to refine the diffusion start point. This accelerates the inference process to 10 steps while preserving sampling quality, in a training-free manner. Our method demonstrates state-of-the-art performance among both full-scale and accelerated models. The code will be made publicly available.

CuNeRF: Cube-Based Neural Radiance Field for Zero-Shot Medical Image Arbitrary-Scale Super Resolution

Medical image arbitrary-scale super-resolution (MIASSR) has recently gained widespread attention, aiming to super sample medical volumes at arbitrary scales via a single model. However, existing MIASSR methods face two major limitations: (i) reliance on high-resolution (HR) volumes and (ii) limited generalization ability, which restricts their application in various scenarios. To overcome these limitations, we propose Cube-based Neural Radiance Field (CuNeRF), a zero-shot MIASSR framework that can yield medical images at arbitrary scales and viewpoints in a continuous domain. Unlike existing MIASSR methods that fit the mapping between low-resolution (LR) and HR volumes, CuNeRF focuses on building a coordinate-intensity continuous representation from LR volumes without the need for HR references. This is achieved by the proposed differentiable modules: including cube-based sampling, isotropic volume rendering, and cube-based hierarchical rendering. Through extensive experiments on magnetic resource imaging (MRI) and computed tomography (CT) modalities, we demonstrate that CuNeRF outperforms state-of-the-art MIASSR methods. CuNeRF yields better visual verisimilitude and reduces aliasing artifacts at various upsampling factors. Moreover, our CuNeRF does not need any LR-HR training pairs, which is more flexible and easier to be used than others. Our code will be publicly available soon.

PIE: Simulating Disease Progression via Progressive Image Editing

Disease progression simulation is a crucial area of research that has significant implications for clinical diagnosis, prognosis, and treatment. One major challenge in this field is the lack of continuous medical imaging monitoring of individual patients over time. To address this issue, we develop a novel framework termed Progressive Image Editing (PIE) that enables controlled manipulation of disease-related image features, facilitating precise and realistic disease progression simulation. Specifically, we leverage recent advancements in text-to-image generative models to simulate disease progression accurately and personalize it for each patient. We theoretically analyze the iterative refining process in our framework as a gradient descent with an exponentially decayed learning rate. To validate our framework, we conduct experiments in three medical imaging domains. Our results demonstrate the superiority of PIE over existing methods such as Stable Diffusion Walk and Style-Based Manifold Extrapolation based on CLIP score (Realism) and Disease Classification Confidence (Alignment). Our user study collected feedback from 35 veteran physicians to assess the generated progressions. Remarkably, 76.2% of the feedback agrees with the fidelity of the generated progressions. To our best knowledge, PIE is the first of its kind to generate disease progression images meeting real-world standards. It is a promising tool for medical research and clinical practice, potentially allowing healthcare providers to model disease trajectories over time, predict future treatment responses, and improve patient outcomes.

UniTune: Text-Driven Image Editing by Fine Tuning a Diffusion Model on a Single Image

Text-driven image generation methods have shown impressive results recently, allowing casual users to generate high quality images by providing textual descriptions. However, similar capabilities for editing existing images are still out of reach. Text-driven image editing methods usually need edit masks, struggle with edits that require significant visual changes and cannot easily keep specific details of the edited portion. In this paper we make the observation that image-generation models can be converted to image-editing models simply by fine-tuning them on a single image. We also show that initializing the stochastic sampler with a noised version of the base image before the sampling and interpolating relevant details from the base image after sampling further increase the quality of the edit operation. Combining these observations, we propose UniTune, a novel image editing method. UniTune gets as input an arbitrary image and a textual edit description, and carries out the edit while maintaining high fidelity to the input image. UniTune does not require additional inputs, like masks or sketches, and can perform multiple edits on the same image without retraining. We test our method using the Imagen model in a range of different use cases. We demonstrate that it is broadly applicable and can perform a surprisingly wide range of expressive editing operations, including those requiring significant visual changes that were previously impossible.

Fine-Tuning and Training of DenseNet for Histopathology Image Representation Using TCGA Diagnostic Slides

Feature vectors provided by pre-trained deep artificial neural networks have become a dominant source for image representation in recent literature. Their contribution to the performance of image analysis can be improved through finetuning. As an ultimate solution, one might even train a deep network from scratch with the domain-relevant images, a highly desirable option which is generally impeded in pathology by lack of labeled images and the computational expense. In this study, we propose a new network, namely KimiaNet, that employs the topology of the DenseNet with four dense blocks, fine-tuned and trained with histopathology images in different configurations. We used more than 240,000 image patches with 1000x1000 pixels acquired at 20x magnification through our proposed "highcellularity mosaic" approach to enable the usage of weak labels of 7,126 whole slide images of formalin-fixed paraffin-embedded human pathology samples publicly available through the The Cancer Genome Atlas (TCGA) repository. We tested KimiaNet using three public datasets, namely TCGA, endometrial cancer images, and colorectal cancer images by evaluating the performance of search and classification when corresponding features of different networks are used for image representation. As well, we designed and trained multiple convolutional batch-normalized ReLU (CBR) networks. The results show that KimiaNet provides superior results compared to the original DenseNet and smaller CBR networks when used as feature extractor to represent histopathology images.

Towards a clinically accessible radiology foundation model: open-access and lightweight, with automated evaluation

The scaling laws and extraordinary performance of large foundation models motivate the development and utilization of such models in biomedicine. However, despite early promising results on some biomedical benchmarks, there are still major challenges that need to be addressed before these models can be used in real-world clinics. Frontier general-domain models such as GPT-4V still have significant performance gaps in multimodal biomedical applications. More importantly, less-acknowledged pragmatic issues, including accessibility, model cost, and tedious manual evaluation make it hard for clinicians to use state-of-the-art large models directly on private patient data. Here, we explore training open-source small multimodal models (SMMs) to bridge competency gaps for unmet clinical needs in radiology. To maximize data efficiency, we adopt a modular approach by incorporating state-of-the-art pre-trained models for image and text modalities, and focusing on training a lightweight adapter to ground each modality to the text embedding space, as exemplified by LLaVA-Med. For training, we assemble a large dataset of over 697 thousand radiology image-text pairs. For evaluation, we propose CheXprompt, a GPT-4-based metric for factuality evaluation, and demonstrate its parity with expert evaluation. For best practice, we conduct a systematic ablation study on various choices in data engineering and multimodal training. The resulting LlaVA-Rad (7B) model attains state-of-the-art results on standard radiology tasks such as report generation and cross-modal retrieval, even outperforming much larger models such as GPT-4V and Med-PaLM M (84B). The inference of LlaVA-Rad is fast and can be performed on a single V100 GPU in private settings, offering a promising state-of-the-art tool for real-world clinical applications.

Orthogonal Adaptation for Modular Customization of Diffusion Models

Customization techniques for text-to-image models have paved the way for a wide range of previously unattainable applications, enabling the generation of specific concepts across diverse contexts and styles. While existing methods facilitate high-fidelity customization for individual concepts or a limited, pre-defined set of them, they fall short of achieving scalability, where a single model can seamlessly render countless concepts. In this paper, we address a new problem called Modular Customization, with the goal of efficiently merging customized models that were fine-tuned independently for individual concepts. This allows the merged model to jointly synthesize concepts in one image without compromising fidelity or incurring any additional computational costs. To address this problem, we introduce Orthogonal Adaptation, a method designed to encourage the customized models, which do not have access to each other during fine-tuning, to have orthogonal residual weights. This ensures that during inference time, the customized models can be summed with minimal interference. Our proposed method is both simple and versatile, applicable to nearly all optimizable weights in the model architecture. Through an extensive set of quantitative and qualitative evaluations, our method consistently outperforms relevant baselines in terms of efficiency and identity preservation, demonstrating a significant leap toward scalable customization of diffusion models.

Binary Latent Diffusion

In this paper, we show that a binary latent space can be explored for compact yet expressive image representations. We model the bi-directional mappings between an image and the corresponding latent binary representation by training an auto-encoder with a Bernoulli encoding distribution. On the one hand, the binary latent space provides a compact discrete image representation of which the distribution can be modeled more efficiently than pixels or continuous latent representations. On the other hand, we now represent each image patch as a binary vector instead of an index of a learned cookbook as in discrete image representations with vector quantization. In this way, we obtain binary latent representations that allow for better image quality and high-resolution image representations without any multi-stage hierarchy in the latent space. In this binary latent space, images can now be generated effectively using a binary latent diffusion model tailored specifically for modeling the prior over the binary image representations. We present both conditional and unconditional image generation experiments with multiple datasets, and show that the proposed method performs comparably to state-of-the-art methods while dramatically improving the sampling efficiency to as few as 16 steps without using any test-time acceleration. The proposed framework can also be seamlessly scaled to 1024 times 1024 high-resolution image generation without resorting to latent hierarchy or multi-stage refinements.

Do DALL-E and Flamingo Understand Each Other?

The field of multimodal research focusing on the comprehension and creation of both images and text has witnessed significant strides. This progress is exemplified by the emergence of sophisticated models dedicated to image captioning at scale, such as the notable Flamingo model and text-to-image generative models, with DALL-E serving as a prominent example. An interesting question worth exploring in this domain is whether Flamingo and DALL-E understand each other. To study this question, we propose a reconstruction task where Flamingo generates a description for a given image and DALL-E uses this description as input to synthesize a new image. We argue that these models understand each other if the generated image is similar to the given image. Specifically, we study the relationship between the quality of the image reconstruction and that of the text generation. We find that an optimal description of an image is one that gives rise to a generated image similar to the original one. The finding motivates us to propose a unified framework to finetune the text-to-image and image-to-text models. Concretely, the reconstruction part forms a regularization loss to guide the tuning of the models. Extensive experiments on multiple datasets with different image captioning and image generation models validate our findings and demonstrate the effectiveness of our proposed unified framework. As DALL-E and Flamingo are not publicly available, we use Stable Diffusion and BLIP in the remaining work. Project website: https://dalleflamingo.github.io.

FreeCustom: Tuning-Free Customized Image Generation for Multi-Concept Composition

Benefiting from large-scale pre-trained text-to-image (T2I) generative models, impressive progress has been achieved in customized image generation, which aims to generate user-specified concepts. Existing approaches have extensively focused on single-concept customization and still encounter challenges when it comes to complex scenarios that involve combining multiple concepts. These approaches often require retraining/fine-tuning using a few images, leading to time-consuming training processes and impeding their swift implementation. Furthermore, the reliance on multiple images to represent a singular concept increases the difficulty of customization. To this end, we propose FreeCustom, a novel tuning-free method to generate customized images of multi-concept composition based on reference concepts, using only one image per concept as input. Specifically, we introduce a new multi-reference self-attention (MRSA) mechanism and a weighted mask strategy that enables the generated image to access and focus more on the reference concepts. In addition, MRSA leverages our key finding that input concepts are better preserved when providing images with context interactions. Experiments show that our method's produced images are consistent with the given concepts and better aligned with the input text. Our method outperforms or performs on par with other training-based methods in terms of multi-concept composition and single-concept customization, but is simpler. Codes can be found at https://github.com/aim-uofa/FreeCustom.

Beyond Image Borders: Learning Feature Extrapolation for Unbounded Image Composition

For improving image composition and aesthetic quality, most existing methods modulate the captured images by striking out redundant content near the image borders. However, such image cropping methods are limited in the range of image views. Some methods have been suggested to extrapolate the images and predict cropping boxes from the extrapolated image. Nonetheless, the synthesized extrapolated regions may be included in the cropped image, making the image composition result not real and potentially with degraded image quality. In this paper, we circumvent this issue by presenting a joint framework for both unbounded recommendation of camera view and image composition (i.e., UNIC). In this way, the cropped image is a sub-image of the image acquired by the predicted camera view, and thus can be guaranteed to be real and consistent in image quality. Specifically, our framework takes the current camera preview frame as input and provides a recommendation for view adjustment, which contains operations unlimited by the image borders, such as zooming in or out and camera movement. To improve the prediction accuracy of view adjustment prediction, we further extend the field of view by feature extrapolation. After one or several times of view adjustments, our method converges and results in both a camera view and a bounding box showing the image composition recommendation. Extensive experiments are conducted on the datasets constructed upon existing image cropping datasets, showing the effectiveness of our UNIC in unbounded recommendation of camera view and image composition. The source code, dataset, and pretrained models is available at https://github.com/liuxiaoyu1104/UNIC.

Learning to Generate Semantic Layouts for Higher Text-Image Correspondence in Text-to-Image Synthesis

Existing text-to-image generation approaches have set high standards for photorealism and text-image correspondence, largely benefiting from web-scale text-image datasets, which can include up to 5~billion pairs. However, text-to-image generation models trained on domain-specific datasets, such as urban scenes, medical images, and faces, still suffer from low text-image correspondence due to the lack of text-image pairs. Additionally, collecting billions of text-image pairs for a specific domain can be time-consuming and costly. Thus, ensuring high text-image correspondence without relying on web-scale text-image datasets remains a challenging task. In this paper, we present a novel approach for enhancing text-image correspondence by leveraging available semantic layouts. Specifically, we propose a Gaussian-categorical diffusion process that simultaneously generates both images and corresponding layout pairs. Our experiments reveal that we can guide text-to-image generation models to be aware of the semantics of different image regions, by training the model to generate semantic labels for each pixel. We demonstrate that our approach achieves higher text-image correspondence compared to existing text-to-image generation approaches in the Multi-Modal CelebA-HQ and the Cityscapes dataset, where text-image pairs are scarce. Codes are available in this https://pmh9960.github.io/research/GCDP

CIFAKE: Image Classification and Explainable Identification of AI-Generated Synthetic Images

Recent technological advances in synthetic data have enabled the generation of images with such high quality that human beings cannot tell the difference between real-life photographs and Artificial Intelligence (AI) generated images. Given the critical necessity of data reliability and authentication, this article proposes to enhance our ability to recognise AI-generated images through computer vision. Initially, a synthetic dataset is generated that mirrors the ten classes of the already available CIFAR-10 dataset with latent diffusion which provides a contrasting set of images for comparison to real photographs. The model is capable of generating complex visual attributes, such as photorealistic reflections in water. The two sets of data present as a binary classification problem with regard to whether the photograph is real or generated by AI. This study then proposes the use of a Convolutional Neural Network (CNN) to classify the images into two categories; Real or Fake. Following hyperparameter tuning and the training of 36 individual network topologies, the optimal approach could correctly classify the images with 92.98% accuracy. Finally, this study implements explainable AI via Gradient Class Activation Mapping to explore which features within the images are useful for classification. Interpretation reveals interesting concepts within the image, in particular, noting that the actual entity itself does not hold useful information for classification; instead, the model focuses on small visual imperfections in the background of the images. The complete dataset engineered for this study, referred to as the CIFAKE dataset, is made publicly available to the research community for future work.

Learning to Generate Images with Perceptual Similarity Metrics

Deep networks are increasingly being applied to problems involving image synthesis, e.g., generating images from textual descriptions and reconstructing an input image from a compact representation. Supervised training of image-synthesis networks typically uses a pixel-wise loss (PL) to indicate the mismatch between a generated image and its corresponding target image. We propose instead to use a loss function that is better calibrated to human perceptual judgments of image quality: the multiscale structural-similarity score (MS-SSIM). Because MS-SSIM is differentiable, it is easily incorporated into gradient-descent learning. We compare the consequences of using MS-SSIM versus PL loss on training deterministic and stochastic autoencoders. For three different architectures, we collected human judgments of the quality of image reconstructions. Observers reliably prefer images synthesized by MS-SSIM-optimized models over those synthesized by PL-optimized models, for two distinct PL measures (ell_1 and ell_2 distances). We also explore the effect of training objective on image encoding and analyze conditions under which perceptually-optimized representations yield better performance on image classification. Finally, we demonstrate the superiority of perceptually-optimized networks for super-resolution imaging. Just as computer vision has advanced through the use of convolutional architectures that mimic the structure of the mammalian visual system, we argue that significant additional advances can be made in modeling images through the use of training objectives that are well aligned to characteristics of human perception.

Any2AnyTryon: Leveraging Adaptive Position Embeddings for Versatile Virtual Clothing Tasks

Image-based virtual try-on (VTON) aims to generate a virtual try-on result by transferring an input garment onto a target person's image. However, the scarcity of paired garment-model data makes it challenging for existing methods to achieve high generalization and quality in VTON. Also, it limits the ability to generate mask-free try-ons. To tackle the data scarcity problem, approaches such as Stable Garment and MMTryon use a synthetic data strategy, effectively increasing the amount of paired data on the model side. However, existing methods are typically limited to performing specific try-on tasks and lack user-friendliness. To enhance the generalization and controllability of VTON generation, we propose Any2AnyTryon, which can generate try-on results based on different textual instructions and model garment images to meet various needs, eliminating the reliance on masks, poses, or other conditions. Specifically, we first construct the virtual try-on dataset LAION-Garment, the largest known open-source garment try-on dataset. Then, we introduce adaptive position embedding, which enables the model to generate satisfactory outfitted model images or garment images based on input images of different sizes and categories, significantly enhancing the generalization and controllability of VTON generation. In our experiments, we demonstrate the effectiveness of our Any2AnyTryon and compare it with existing methods. The results show that Any2AnyTryon enables flexible, controllable, and high-quality image-based virtual try-on generation.https://logn-2024.github.io/Any2anyTryonProjectPage/

Guide-and-Rescale: Self-Guidance Mechanism for Effective Tuning-Free Real Image Editing

Despite recent advances in large-scale text-to-image generative models, manipulating real images with these models remains a challenging problem. The main limitations of existing editing methods are that they either fail to perform with consistent quality on a wide range of image edits or require time-consuming hyperparameter tuning or fine-tuning of the diffusion model to preserve the image-specific appearance of the input image. We propose a novel approach that is built upon a modified diffusion sampling process via the guidance mechanism. In this work, we explore the self-guidance technique to preserve the overall structure of the input image and its local regions appearance that should not be edited. In particular, we explicitly introduce layout-preserving energy functions that are aimed to save local and global structures of the source image. Additionally, we propose a noise rescaling mechanism that allows to preserve noise distribution by balancing the norms of classifier-free guidance and our proposed guiders during generation. Such a guiding approach does not require fine-tuning the diffusion model and exact inversion process. As a result, the proposed method provides a fast and high-quality editing mechanism. In our experiments, we show through human evaluation and quantitative analysis that the proposed method allows to produce desired editing which is more preferable by humans and also achieves a better trade-off between editing quality and preservation of the original image. Our code is available at https://github.com/FusionBrainLab/Guide-and-Rescale.

Augmented Conditioning Is Enough For Effective Training Image Generation

Image generation abilities of text-to-image diffusion models have significantly advanced, yielding highly photo-realistic images from descriptive text and increasing the viability of leveraging synthetic images to train computer vision models. To serve as effective training data, generated images must be highly realistic while also sufficiently diverse within the support of the target data distribution. Yet, state-of-the-art conditional image generation models have been primarily optimized for creative applications, prioritizing image realism and prompt adherence over conditional diversity. In this paper, we investigate how to improve the diversity of generated images with the goal of increasing their effectiveness to train downstream image classification models, without fine-tuning the image generation model. We find that conditioning the generation process on an augmented real image and text prompt produces generations that serve as effective synthetic datasets for downstream training. Conditioning on real training images contextualizes the generation process to produce images that are in-domain with the real image distribution, while data augmentations introduce visual diversity that improves the performance of the downstream classifier. We validate augmentation-conditioning on a total of five established long-tail and few-shot image classification benchmarks and show that leveraging augmentations to condition the generation process results in consistent improvements over the state-of-the-art on the long-tailed benchmark and remarkable gains in extreme few-shot regimes of the remaining four benchmarks. These results constitute an important step towards effectively leveraging synthetic data for downstream training.

Improving Fractal Pre-training

The deep neural networks used in modern computer vision systems require enormous image datasets to train them. These carefully-curated datasets typically have a million or more images, across a thousand or more distinct categories. The process of creating and curating such a dataset is a monumental undertaking, demanding extensive effort and labelling expense and necessitating careful navigation of technical and social issues such as label accuracy, copyright ownership, and content bias. What if we had a way to harness the power of large image datasets but with few or none of the major issues and concerns currently faced? This paper extends the recent work of Kataoka et. al. (2020), proposing an improved pre-training dataset based on dynamically-generated fractal images. Challenging issues with large-scale image datasets become points of elegance for fractal pre-training: perfect label accuracy at zero cost; no need to store/transmit large image archives; no privacy/demographic bias/concerns of inappropriate content, as no humans are pictured; limitless supply and diversity of images; and the images are free/open-source. Perhaps surprisingly, avoiding these difficulties imposes only a small penalty in performance. Leveraging a newly-proposed pre-training task -- multi-instance prediction -- our experiments demonstrate that fine-tuning a network pre-trained using fractals attains 92.7-98.1% of the accuracy of an ImageNet pre-trained network.

Imagine yourself: Tuning-Free Personalized Image Generation

Diffusion models have demonstrated remarkable efficacy across various image-to-image tasks. In this research, we introduce Imagine yourself, a state-of-the-art model designed for personalized image generation. Unlike conventional tuning-based personalization techniques, Imagine yourself operates as a tuning-free model, enabling all users to leverage a shared framework without individualized adjustments. Moreover, previous work met challenges balancing identity preservation, following complex prompts and preserving good visual quality, resulting in models having strong copy-paste effect of the reference images. Thus, they can hardly generate images following prompts that require significant changes to the reference image, \eg, changing facial expression, head and body poses, and the diversity of the generated images is low. To address these limitations, our proposed method introduces 1) a new synthetic paired data generation mechanism to encourage image diversity, 2) a fully parallel attention architecture with three text encoders and a fully trainable vision encoder to improve the text faithfulness, and 3) a novel coarse-to-fine multi-stage finetuning methodology that gradually pushes the boundary of visual quality. Our study demonstrates that Imagine yourself surpasses the state-of-the-art personalization model, exhibiting superior capabilities in identity preservation, visual quality, and text alignment. This model establishes a robust foundation for various personalization applications. Human evaluation results validate the model's SOTA superiority across all aspects (identity preservation, text faithfulness, and visual appeal) compared to the previous personalization models.

Scaling Laws of Synthetic Images for Model Training ... for Now

Recent significant advances in text-to-image models unlock the possibility of training vision systems using synthetic images, potentially overcoming the difficulty of collecting curated data at scale. It is unclear, however, how these models behave at scale, as more synthetic data is added to the training set. In this paper we study the scaling laws of synthetic images generated by state of the art text-to-image models, for the training of supervised models: image classifiers with label supervision, and CLIP with language supervision. We identify several factors, including text prompts, classifier-free guidance scale, and types of text-to-image models, that significantly affect scaling behavior. After tuning these factors, we observe that synthetic images demonstrate a scaling trend similar to, but slightly less effective than, real images in CLIP training, while they significantly underperform in scaling when training supervised image classifiers. Our analysis indicates that the main reason for this underperformance is the inability of off-the-shelf text-to-image models to generate certain concepts, a limitation that significantly impairs the training of image classifiers. Our findings also suggest that scaling synthetic data can be particularly effective in scenarios such as: (1) when there is a limited supply of real images for a supervised problem (e.g., fewer than 0.5 million images in ImageNet), (2) when the evaluation dataset diverges significantly from the training data, indicating the out-of-distribution scenario, or (3) when synthetic data is used in conjunction with real images, as demonstrated in the training of CLIP models.

Fooling Contrastive Language-Image Pre-trained Models with CLIPMasterPrints

Models leveraging both visual and textual data such as Contrastive Language-Image Pre-training (CLIP), are the backbone of many recent advances in artificial intelligence. In this work, we show that despite their versatility, such models are vulnerable to what we refer to as fooling master images. Fooling master images are capable of maximizing the confidence score of a CLIP model for a significant number of widely varying prompts, while being either unrecognizable or unrelated to the attacked prompts for humans. The existence of such images is problematic as it could be used by bad actors to maliciously interfere with CLIP-trained image retrieval models in production with comparably small effort as a single image can attack many different prompts. We demonstrate how fooling master images for CLIP (CLIPMasterPrints) can be mined using stochastic gradient descent, projected gradient descent, or blackbox optimization. Contrary to many common adversarial attacks, the blackbox optimization approach allows us to mine CLIPMasterPrints even when the weights of the model are not accessible. We investigate the properties of the mined images, and find that images trained on a small number of image captions generalize to a much larger number of semantically related captions. We evaluate possible mitigation strategies, where we increase the robustness of the model and introduce an approach to automatically detect CLIPMasterPrints to sanitize the input of vulnerable models. Finally, we find that vulnerability to CLIPMasterPrints is related to a modality gap in contrastive pre-trained multi-modal networks. Code available at https://github.com/matfrei/CLIPMasterPrints.

Enhancing Image Rescaling using Dual Latent Variables in Invertible Neural Network

Normalizing flow models have been used successfully for generative image super-resolution (SR) by approximating complex distribution of natural images to simple tractable distribution in latent space through Invertible Neural Networks (INN). These models can generate multiple realistic SR images from one low-resolution (LR) input using randomly sampled points in the latent space, simulating the ill-posed nature of image upscaling where multiple high-resolution (HR) images correspond to the same LR. Lately, the invertible process in INN has also been used successfully by bidirectional image rescaling models like IRN and HCFlow for joint optimization of downscaling and inverse upscaling, resulting in significant improvements in upscaled image quality. While they are optimized for image downscaling too, the ill-posed nature of image downscaling, where one HR image could be downsized to multiple LR images depending on different interpolation kernels and resampling methods, is not considered. A new downscaling latent variable, in addition to the original one representing uncertainties in image upscaling, is introduced to model variations in the image downscaling process. This dual latent variable enhancement is applicable to different image rescaling models and it is shown in extensive experiments that it can improve image upscaling accuracy consistently without sacrificing image quality in downscaled LR images. It is also shown to be effective in enhancing other INN-based models for image restoration applications like image hiding.

RAD-DINO: Exploring Scalable Medical Image Encoders Beyond Text Supervision

Language-supervised pre-training has proven to be a valuable method for extracting semantically meaningful features from images, serving as a foundational element in multimodal systems within the computer vision and medical imaging domains. However, resulting features are limited by the information contained within the text. This is particularly problematic in medical imaging, where radiologists' written findings focus on specific observations; a challenge compounded by the scarcity of paired imaging-text data due to concerns over leakage of personal health information. In this work, we fundamentally challenge the prevailing reliance on language supervision for learning general purpose biomedical imaging encoders. We introduce RAD-DINO, a biomedical image encoder pre-trained solely on unimodal biomedical imaging data that obtains similar or greater performance than state-of-the-art biomedical language supervised models on a diverse range of benchmarks. Specifically, the quality of learned representations is evaluated on standard imaging tasks (classification and semantic segmentation), and a vision-language alignment task (text report generation from images). To further demonstrate the drawback of language supervision, we show that features from RAD-DINO correlate with other medical records (e.g., sex or age) better than language-supervised models, which are generally not mentioned in radiology reports. Finally, we conduct a series of ablations determining the factors in RAD-DINO's performance; notably, we observe that RAD-DINO's downstream performance scales well with the quantity and diversity of training data, demonstrating that image-only supervision is a scalable approach for training a foundational biomedical image encoder.

Attention Calibration for Disentangled Text-to-Image Personalization

Recent thrilling progress in large-scale text-to-image (T2I) models has unlocked unprecedented synthesis quality of AI-generated content (AIGC) including image generation, 3D and video composition. Further, personalized techniques enable appealing customized production of a novel concept given only several images as reference. However, an intriguing problem persists: Is it possible to capture multiple, novel concepts from one single reference image? In this paper, we identify that existing approaches fail to preserve visual consistency with the reference image and eliminate cross-influence from concepts. To alleviate this, we propose an attention calibration mechanism to improve the concept-level understanding of the T2I model. Specifically, we first introduce new learnable modifiers bound with classes to capture attributes of multiple concepts. Then, the classes are separated and strengthened following the activation of the cross-attention operation, ensuring comprehensive and self-contained concepts. Additionally, we suppress the attention activation of different classes to mitigate mutual influence among concepts. Together, our proposed method, dubbed DisenDiff, can learn disentangled multiple concepts from one single image and produce novel customized images with learned concepts. We demonstrate that our method outperforms the current state of the art in both qualitative and quantitative evaluations. More importantly, our proposed techniques are compatible with LoRA and inpainting pipelines, enabling more interactive experiences.

MoRE: Multi-Modal Contrastive Pre-training with Transformers on X-Rays, ECGs, and Diagnostic Report

In this paper, we introduce a novel Multi-Modal Contrastive Pre-training Framework that synergistically combines X-rays, electrocardiograms (ECGs), and radiology/cardiology reports. Our approach leverages transformers to encode these diverse modalities into a unified representation space, aiming to enhance diagnostic accuracy and facilitate comprehensive patient assessments. We utilize LoRA-Peft to significantly reduce trainable parameters in the LLM and incorporate recent linear attention dropping strategy in the Vision Transformer(ViT) for smoother attention. Furthermore, we provide novel multimodal attention explanations and retrieval for our model. To the best of our knowledge, we are the first to propose an integrated model that combines X-ray, ECG, and Radiology/Cardiology Report with this approach. By utilizing contrastive loss, MoRE effectively aligns modality-specific features into a coherent embedding, which supports various downstream tasks such as zero-shot classification and multimodal retrieval. Employing our proposed methodology, we achieve state-of-the-art (SOTA) on the Mimic-IV, CheXpert, Edema Severity, and PtbXl downstream datasets, surpassing existing multimodal approaches. Our proposed framework shows significant improvements in capturing intricate inter-modal relationships and its robustness in medical diagnosis that establishes a framework for future research in multimodal learning in the healthcare sector.

Intensive Vision-guided Network for Radiology Report Generation

Automatic radiology report generation is booming due to its huge application potential for the healthcare industry. However, existing computer vision and natural language processing approaches to tackle this problem are limited in two aspects. First, when extracting image features, most of them neglect multi-view reasoning in vision and model single-view structure of medical images, such as space-view or channel-view. However, clinicians rely on multi-view imaging information for comprehensive judgment in daily clinical diagnosis. Second, when generating reports, they overlook context reasoning with multi-modal information and focus on pure textual optimization utilizing retrieval-based methods. We aim to address these two issues by proposing a model that better simulates clinicians' perspectives and generates more accurate reports. Given the above limitation in feature extraction, we propose a Globally-intensive Attention (GIA) module in the medical image encoder to simulate and integrate multi-view vision perception. GIA aims to learn three types of vision perception: depth view, space view, and pixel view. On the other hand, to address the above problem in report generation, we explore how to involve multi-modal signals to generate precisely matched reports, i.e., how to integrate previously predicted words with region-aware visual content in next word prediction. Specifically, we design a Visual Knowledge-guided Decoder (VKGD), which can adaptively consider how much the model needs to rely on visual information and previously predicted text to assist next word prediction. Hence, our final Intensive Vision-guided Network (IVGN) framework includes a GIA-guided Visual Encoder and the VKGD. Experiments on two commonly-used datasets IU X-Ray and MIMIC-CXR demonstrate the superior ability of our method compared with other state-of-the-art approaches.

Contrastive Learning of Medical Visual Representations from Paired Images and Text

Learning visual representations of medical images (e.g., X-rays) is core to medical image understanding but its progress has been held back by the scarcity of human annotations. Existing work commonly relies on fine-tuning weights transferred from ImageNet pretraining, which is suboptimal due to drastically different image characteristics, or rule-based label extraction from the textual report data paired with medical images, which is inaccurate and hard to generalize. Meanwhile, several recent studies show exciting results from unsupervised contrastive learning from natural images, but we find these methods help little on medical images because of their high inter-class similarity. We propose ConVIRT, an alternative unsupervised strategy to learn medical visual representations by exploiting naturally occurring paired descriptive text. Our new method of pretraining medical image encoders with the paired text data via a bidirectional contrastive objective between the two modalities is domain-agnostic, and requires no additional expert input. We test ConVIRT by transferring our pretrained weights to 4 medical image classification tasks and 2 zero-shot retrieval tasks, and show that it leads to image representations that considerably outperform strong baselines in most settings. Notably, in all 4 classification tasks, our method requires only 10\% as much labeled training data as an ImageNet initialized counterpart to achieve better or comparable performance, demonstrating superior data efficiency.

LVM-Med: Learning Large-Scale Self-Supervised Vision Models for Medical Imaging via Second-order Graph Matching

Obtaining large pre-trained models that can be fine-tuned to new tasks with limited annotated samples has remained an open challenge for medical imaging data. While pre-trained deep networks on ImageNet and vision-language foundation models trained on web-scale data are prevailing approaches, their effectiveness on medical tasks is limited due to the significant domain shift between natural and medical images. To bridge this gap, we introduce LVM-Med, the first family of deep networks trained on large-scale medical datasets. We have collected approximately 1.3 million medical images from 55 publicly available datasets, covering a large number of organs and modalities such as CT, MRI, X-ray, and Ultrasound. We benchmark several state-of-the-art self-supervised algorithms on this dataset and propose a novel self-supervised contrastive learning algorithm using a graph-matching formulation. The proposed approach makes three contributions: (i) it integrates prior pair-wise image similarity metrics based on local and global information; (ii) it captures the structural constraints of feature embeddings through a loss function constructed via a combinatorial graph-matching objective; and (iii) it can be trained efficiently end-to-end using modern gradient-estimation techniques for black-box solvers. We thoroughly evaluate the proposed LVM-Med on 15 downstream medical tasks ranging from segmentation and classification to object detection, and both for the in and out-of-distribution settings. LVM-Med empirically outperforms a number of state-of-the-art supervised, self-supervised, and foundation models. For challenging tasks such as Brain Tumor Classification or Diabetic Retinopathy Grading, LVM-Med improves previous vision-language models trained on 1 billion masks by 6-7% while using only a ResNet-50.

MedSyn: Text-guided Anatomy-aware Synthesis of High-Fidelity 3D CT Images

This paper introduces an innovative methodology for producing high-quality 3D lung CT images guided by textual information. While diffusion-based generative models are increasingly used in medical imaging, current state-of-the-art approaches are limited to low-resolution outputs and underutilize radiology reports' abundant information. The radiology reports can enhance the generation process by providing additional guidance and offering fine-grained control over the synthesis of images. Nevertheless, expanding text-guided generation to high-resolution 3D images poses significant memory and anatomical detail-preserving challenges. Addressing the memory issue, we introduce a hierarchical scheme that uses a modified UNet architecture. We start by synthesizing low-resolution images conditioned on the text, serving as a foundation for subsequent generators for complete volumetric data. To ensure the anatomical plausibility of the generated samples, we provide further guidance by generating vascular, airway, and lobular segmentation masks in conjunction with the CT images. The model demonstrates the capability to use textual input and segmentation tasks to generate synthesized images. The results of comparative assessments indicate that our approach exhibits superior performance compared to the most advanced models based on GAN and diffusion techniques, especially in accurately retaining crucial anatomical features such as fissure lines, airways, and vascular structures. This innovation introduces novel possibilities. This study focuses on two main objectives: (1) the development of a method for creating images based on textual prompts and anatomical components, and (2) the capability to generate new images conditioning on anatomical elements. The advancements in image generation can be applied to enhance numerous downstream tasks.

Day-to-Night Image Synthesis for Training Nighttime Neural ISPs

Many flagship smartphone cameras now use a dedicated neural image signal processor (ISP) to render noisy raw sensor images to the final processed output. Training nightmode ISP networks relies on large-scale datasets of image pairs with: (1) a noisy raw image captured with a short exposure and a high ISO gain; and (2) a ground truth low-noise raw image captured with a long exposure and low ISO that has been rendered through the ISP. Capturing such image pairs is tedious and time-consuming, requiring careful setup to ensure alignment between the image pairs. In addition, ground truth images are often prone to motion blur due to the long exposure. To address this problem, we propose a method that synthesizes nighttime images from daytime images. Daytime images are easy to capture, exhibit low-noise (even on smartphone cameras) and rarely suffer from motion blur. We outline a processing framework to convert daytime raw images to have the appearance of realistic nighttime raw images with different levels of noise. Our procedure allows us to easily produce aligned noisy and clean nighttime image pairs. We show the effectiveness of our synthesis framework by training neural ISPs for nightmode rendering. Furthermore, we demonstrate that using our synthetic nighttime images together with small amounts of real data (e.g., 5% to 10%) yields performance almost on par with training exclusively on real nighttime images. Our dataset and code are available at https://github.com/SamsungLabs/day-to-night.

Re-Imagen: Retrieval-Augmented Text-to-Image Generator

Research on text-to-image generation has witnessed significant progress in generating diverse and photo-realistic images, driven by diffusion and auto-regressive models trained on large-scale image-text data. Though state-of-the-art models can generate high-quality images of common entities, they often have difficulty generating images of uncommon entities, such as `Chortai (dog)' or `Picarones (food)'. To tackle this issue, we present the Retrieval-Augmented Text-to-Image Generator (Re-Imagen), a generative model that uses retrieved information to produce high-fidelity and faithful images, even for rare or unseen entities. Given a text prompt, Re-Imagen accesses an external multi-modal knowledge base to retrieve relevant (image, text) pairs and uses them as references to generate the image. With this retrieval step, Re-Imagen is augmented with the knowledge of high-level semantics and low-level visual details of the mentioned entities, and thus improves its accuracy in generating the entities' visual appearances. We train Re-Imagen on a constructed dataset containing (image, text, retrieval) triples to teach the model to ground on both text prompt and retrieval. Furthermore, we develop a new sampling strategy to interleave the classifier-free guidance for text and retrieval conditions to balance the text and retrieval alignment. Re-Imagen achieves significant gain on FID score over COCO and WikiImage. To further evaluate the capabilities of the model, we introduce EntityDrawBench, a new benchmark that evaluates image generation for diverse entities, from frequent to rare, across multiple object categories including dogs, foods, landmarks, birds, and characters. Human evaluation on EntityDrawBench shows that Re-Imagen can significantly improve the fidelity of generated images, especially on less frequent entities.

PINN surrogate of Li-ion battery models for parameter inference. Part II: Regularization and application of the pseudo-2D model

Bayesian parameter inference is useful to improve Li-ion battery diagnostics and can help formulate battery aging models. However, it is computationally intensive and cannot be easily repeated for multiple cycles, multiple operating conditions, or multiple replicate cells. To reduce the computational cost of Bayesian calibration, numerical solvers for physics-based models can be replaced with faster surrogates. A physics-informed neural network (PINN) is developed as a surrogate for the pseudo-2D (P2D) battery model calibration. For the P2D surrogate, additional training regularization was needed as compared to the PINN single-particle model (SPM) developed in Part I. Both the PINN SPM and P2D surrogate models are exercised for parameter inference and compared to data obtained from a direct numerical solution of the governing equations. A parameter inference study highlights the ability to use these PINNs to calibrate scaling parameters for the cathode Li diffusion and the anode exchange current density. By realizing computational speed-ups of 2250x for the P2D model, as compared to using standard integrating methods, the PINN surrogates enable rapid state-of-health diagnostics. In the low-data availability scenario, the testing error was estimated to 2mV for the SPM surrogate and 10mV for the P2D surrogate which could be mitigated with additional data.

PINN surrogate of Li-ion battery models for parameter inference. Part I: Implementation and multi-fidelity hierarchies for the single-particle model

To plan and optimize energy storage demands that account for Li-ion battery aging dynamics, techniques need to be developed to diagnose battery internal states accurately and rapidly. This study seeks to reduce the computational resources needed to determine a battery's internal states by replacing physics-based Li-ion battery models -- such as the single-particle model (SPM) and the pseudo-2D (P2D) model -- with a physics-informed neural network (PINN) surrogate. The surrogate model makes high-throughput techniques, such as Bayesian calibration, tractable to determine battery internal parameters from voltage responses. This manuscript is the first of a two-part series that introduces PINN surrogates of Li-ion battery models for parameter inference (i.e., state-of-health diagnostics). In this first part, a method is presented for constructing a PINN surrogate of the SPM. A multi-fidelity hierarchical training, where several neural nets are trained with multiple physics-loss fidelities is shown to significantly improve the surrogate accuracy when only training on the governing equation residuals. The implementation is made available in a companion repository (https://github.com/NREL/pinnstripes). The techniques used to develop a PINN surrogate of the SPM are extended in Part II for the PINN surrogate for the P2D battery model, and explore the Bayesian calibration capabilities of both surrogates.

Prostate-Specific Foundation Models for Enhanced Detection of Clinically Significant Cancer

Accurate prostate cancer diagnosis remains challenging. Even when using MRI, radiologists exhibit low specificity and significant inter-observer variability, leading to potential delays or inaccuracies in identifying clinically significant cancers. This leads to numerous unnecessary biopsies and risks of missing clinically significant cancers. Here we present prostate vision contrastive network (ProViCNet), prostate organ-specific vision foundation models for Magnetic Resonance Imaging (MRI) and Trans-Rectal Ultrasound imaging (TRUS) for comprehensive cancer detection. ProViCNet was trained and validated using 4,401 patients across six institutions, as a prostate cancer detection model on radiology images relying on patch-level contrastive learning guided by biopsy confirmed radiologist annotations. ProViCNet demonstrated consistent performance across multiple internal and external validation cohorts with area under the receiver operating curve values ranging from 0.875 to 0.966, significantly outperforming radiologists in the reader study (0.907 versus 0.805, p<0.001) for mpMRI, while achieving 0.670 to 0.740 for TRUS. We also integrated ProViCNet with standard PSA to develop a virtual screening test, and we showed that we can maintain the high sensitivity for detecting clinically significant cancers while more than doubling specificity from 15% to 38% (p<0.001), thereby substantially reducing unnecessary biopsies. These findings highlight that ProViCNet's potential for enhancing prostate cancer diagnosis accuracy and reduce unnecessary biopsies, thereby optimizing diagnostic pathways.