Summarize the following abstract.
The article discusses the challenges of genetic analysis of classical Hodgkin lymphoma (cHL) due to limited cell availability. However, results of whole-exome sequencing and karyotypic analysis of five cHL cell lines have provided information on potentially pathogenic single nucleotide variants (SNV) in several genes, as well as copy number variants in HL-related genes. The study also suggests that defects in genes involved in chromosome duplication and segregation may contribute to the genomic instability of HL.