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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
For example, acetylcholine-producing neurons are connected to the part of the brain that controls muscles of the upper airway and tongue -- and are involved in sleep apnea.hen researchers compared the 13 patients' results with 27 healthy people, they found very different patterns. The 13 sleep-problem patients had far fewer brain cells -- neurons -- that produce the chemicals dopamine and acetylcholine. And those with fewer such neurons had the worst sleep problems.