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Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids.By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.ile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.
Bile Acid Sequestrants (Resins). Bile acid sequestrants are nonsoluble polymers that trap bile acids in the intestinal lumen and promote their excretion in feces. As a consequence, they lower the hepatic cholesterol pool and promote the expression of LDL receptors in the liver.he second generation of bile acid sequestrants, for example colesevelam, is more specific, binds bile acids with greater affinity and is better tolerated. As monotherapy at a daily dose of 3.8 g colesevelam reduces LDL-C by up to 16% in hypercholesterolemic patients.