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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Muscular dystrophies are a group of diseases that are passed down genetically. These diseases cause damage and weakness to muscles over time. This damage and weakness is caused by the lack of a protein called dystrophin, which is necessary for normal muscle function.The absence of this protein can cause problems with walking, swallowing, and muscle coordination.hese diseases cause damage and weakness to muscles over time. This damage and weakness is caused by the lack of a protein called dystrophin, which is necessary for normal muscle function. The absence of this protein can cause problems with walking, swallowing, and muscle coordination.