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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
The autoimmune neuromuscular disorder known as myasthenia gravis is accompanied by muscle weakness along with drooping eyelids and double vision. Metabolic disorders, such as Addisonâs disease and hyperthyroidism, can lead to weakness in one muscle or a group of muscles.t is a common symptom of muscular, neurological and metabolic disorders. Muscular diseases, such as muscular dystrophy and dermatomyositis (disorder characterized by muscle inflammation), are common causes of muscle weakness.