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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Serotonin Basics. Serotonin is one of the most important brain chemicals, or neurotransmitters, for regulating the sleep/wake cycle. Diets high in the amino acid tryptophan can maintain healthy serotonin levels, but lifestyle choices like constant travel and an erratic sleep schedule can disrupt serotonin production.