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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
4 stages of ALS disease. When the upper motor neurons face a serious problem such as degeneration, this causes spastic, also known as muscle contraction or tightening. Whereas, the effects on the lower motor neurons cause loss in the ability to move, muscle shrinkage, twitching, and weakness in the muscles as well.