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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Neurotransmitters and Sleep by Richard H. Hall, 1998 Acetylcholine: Sleep and Thermoregulation In the first part of this lesson we discussed the characteristics of the stages of sleep, the sleep cycle, and the functions of sleep.he acetylcholine neurons that are most important in the sleep process have cell bodies in the Pons and the Basal Forebrain. The pons is located at the base of the brain just above the medulla.