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THE SUPRACHIASMATIC NUCLEI AND THE PINEAL GLAND. Most human bodily functions and behaviours are not âsteady-stateâ. Instead, they fluctuate in 24-hour cycles, such as the sleeping and waking cycle and the cycles for body temperature, hunger, and the secretion of various hormones.
The circadian clock is the central timing system that controls numerous physiological processes. In mammals, one such process is haem biosynthesis, which the clock controls through regulation of the rate-limiting enzyme aminolevulinate synthase 1 (Alas1). Several members of the core clock mechanism are PAS domain proteins, one of which, neuronal PAS 2 (NPAS2), has a haem-binding motif.