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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Examples of muscle diseases include muscular dystrophy. Nervous system diseases, such as paralysis, can lead to shortness of breath. Heart Diseases Many conditions that affect the heart and its capacity to move blood through the lungs can lead to shortness of breath. These conditions include valve diseases of the heart and others. Lung Tissue Diseases