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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
A different brain chemical, though, melatonin, can get from our gut to our brain. Melatonin is a hormone secreted at night by the pineal gland in the center of our brain to help regulate our circadian rhythm.Supplements of the stuff are used to prevent and reduce jet lag, and about 20 years ago MIT got the patent to use melatonin to help people sleep. different brain chemical, though, melatonin, can get from our gut to our brain. Melatonin is a hormone secreted at night by the pineal gland in the center of our brain to help regulate our circadian rhythm.