In addition, thiazolidinediones have several other potential side effects, which make them less appealing as initial or second step therapy. (See 'Cardiovascular effects' below and 'Safety' below.). The pharmacology and use of thiazolidinediones will be reviewed here.
Alcohol impairs brain areas such as the cerebellumâthe control site for your balance and coordinationâand your cerebral cortex, which is responsible for thinking, memory, and learning, says Kimberly S. Walitzer, Ph.D., deputy director of the University at Buffaloâs Research Institute on Addictions.
Alcohol depresses your central nervous system. In some people, the initial reaction may be stimulation. But as you continue to drink, you become sedated. Too much alcohol affects your speech, muscle coordination and vital centers of your brain. A heavy drinking binge may even cause a life-threatening coma or death.