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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Strongest Over the Counter Sleep Aid. Some of the best OTC sleep aid include: Diphenhydramine is used to treat insomnia and difficulty falling asleep or staying asleep. Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery.