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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
1 Metabolic disorders â Inherited diseases that affect how much energy is in the muscle can cause muscle spasms and muscle cramps. 2  These metabolic disorders cause particular muscle enzymes to be deficient, resulting in the last of energy available to the muscle. 3  One of these metabolic disorders are McArdleâs disease.