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Clindamycin does not interact with coumadin directly, though clindamycin is shown to cause liver damage, If this is the case the coumadin can increase INR greater than expected..Regards, kindly click ACCEPT if i have answered to your satisfation, a positive feedback and a bonus will be highly appreciated..esolved Question: my mother take coumadin and was given clindamycin for a tooth infection. Her INR is now 4.8. Her dentist told her that the antibiotic should not interact with her coumadin.
This antibiotic belongs to the category of medicines known as lincosamide. This one works by blocking the process through which bacterial cell synthesized protein. By suppressing this activity, clindamycin blocks the growth of bacteria and this is how stops the spreading of the infection.