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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
It can prevent or inhibit walking, and cause a lack of muscle coordination, spasms, and speech difficulty. Neuromuscular disorders include a variety of conditions, such as muscular dystrophy, multiple sclerosis, and ataxia, which result in degeneration and atrophy of muscle or nerve tissues.