Prevalence of vitamin A deficiency. Vitamin A deficiency (VAD) is a lack of vitamin A in humans. It is common in poorer countries but rarely seen in more developed countries. Nyctalopia (night blindness) is one of the first signs of VAD.revalence of vitamin A deficiency. Vitamin A deficiency (VAD) is a lack of vitamin A in humans. It is common in poorer countries but rarely seen in more developed countries. Nyctalopia (night blindness) is one of the first signs of VAD.
Both lithium and valproate have been reported to increase rat CSF GABA levels. Regarding valproate, animal studies reported that it enhances GABA levels, GABA synaptic release, GAD activity, neuronal GABA responsiveness, and inhibits GABA-T in several brain regions.
While carbidopa reduces the side effects of levodopa, entacapone extends the time levodopa is active in the brain. MAO-B inhibitors also block the action of an enzyme that breaks down dopamine. They may be taken alone early in Parkinson's disease or with other drugs as the disease progresses. MAO-B inhibitors include selegiline (Eldepryl) and rasagaline (Azilect). They are usually used alone, because combining them with other drugs can cause unwanted side effects.