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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
Posted on. (Answer #2). The first settlers of Jamestown endured the problems of hostile Indians, starvation, and poor leadership and government. Jamestown was the second English Colony in the New World (Roanoke being the first) and the Indians attacked the settlers within 3 days of arrival in May of 1607.he colonists arrived at Jamestown on May 13, 1607. At that time, historians estimate that over 14,000 Powhatan Indians lived in Virginia. One of the most apparent problems facing the colonists was communicating with the existing inhabitants.