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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Melatonin is a naturally occurring hormone synthesized in the brain that regulates normal sleep and wake cycles. Melatonin levels naturally start to rise in the evening and remain elevated for most of the night, signalling to our body that it is time to sleep.his is the really important thing you should understand about melatonin: Melatonin is a sleep and body clock regulator â NOT a sleep initiator. Melatonin works with your biological clock by telling your brain when it is time to sleep. Melatonin does not increase your sleep drive or need for sleep.