Providers and consumers should realize that isotretinoin is a potent drug with the potential to cause birth defects and reserve its use for severe recalcitrant nodular acne. Isotretinoin is not for use in mild forms of acne and should not be shared among family members.
Most orbital motorways (or beltways) are purpose-built major highways around a town or city, typically without either signals or road or railroad crossings. In the United States, beltways are commonly parts of the Interstate Highway System. Similar roads in the United Kingdom are often called orbital motorways.
Two photos of the original Skid Road (Mill Street, now Yesler Way) in Seattle, Washington. A skid row or skid road is an impoverished area, typically urban, inhabited by the poor, the homeless, or others considered disreputable or forgotten by society. A skid row may be anything from an impoverished urban district to a red-light district to a gathering area for the homeless.