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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
-Smooth muscle are not under our control (involuntary muscles, they are controlled by what is called the autonomic nervous system). Smooth muscles can be found in the digestive system, mediating the movement of food or can be found surrounding blood vessels mediating blood pressure.