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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
School of Medicine, Family Medicine answered. Chemicals released in the brain in response to happiness include endorphins, dopamine, serotonin and oxytocin. Medicine has created drugs to target these receptors in the brain.However, there are natural ways to activate these parts of the brain.chool of Medicine, Family Medicine answered. Chemicals released in the brain in response to happiness include endorphins, dopamine, serotonin and oxytocin. Medicine has created drugs to target these receptors in the brain.