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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
A: Melatonin is a hormone that helps to regulate the sleep-wake cycle. Levels of the hormone drop during the day and rise at night. Studies suggest that melatonin helps restore sleep when the body's internal clock is disrupted like when people work at night and sleep during the day or as a result of jet lag.