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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Melatonin is the hormone that is most commonly associated with the sleep-wake cycle. Levels of melatonin vary throughout the day (and night) which helps regulate circadian rhythms in the body. [14] Melatonin levels are high at night (during sleep) and low during the day (during wakefulness). The levels of melatonin are regulated by the suprachiasmatic nucleus of the hypothalamus which reacts to the amount of light in the environment. So the darker it is outside of the body the more melatonin there is. [15]