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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Thermoregulation During Sleep. The temperature of both the brain and the body fall during NREM sleep. The longer the NREM-sleep episode, the more the temperature falls. By contrast, brain temperature increases during REM sleep. The control of body and brain temperature is closely tied to sleep regulation.