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Uremia or uraemia (see spelling differences) can be translated as  urea in the blood.Urea is one of the primary components of urine. It can be defined as an excess of amino acid and protein metabolism end products, such as urea and creatinine, in the blood that would be normally excreted in the urine.The Uremic Syndrome can be defined as the terminal clinical manifestation of kidney failure (also called renal failure).It is the signs, symptoms and results from laboratory tests which result from inadequate excretory, regulatory and endocrine function of the kidneys.he Uremic Syndrome can be defined as the terminal clinical manifestation of kidney failure (also called renal failure). It is the signs, symptoms and results from laboratory tests which result from inadequate excretory, regulatory and endocrine function of the kidneys.
The liver produces urea when it metabolises (breaks down) proteins. This is done in hepatocytes (liver cells). Amino acids are first broken down into ammonia, which is highly â¦ soluble and toxic in the blood plasma, so ammonia is joined with carbon dioxide to make urea, this is less soluble and less toxic but a build up of urea is toxic in the blood.