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Ulcerative colitis causes swelling in the large intestine and can lead to cramping, diarrhea, and more. Celiac disease Celiac disease, which is an intestinal reaction to gluten, can cause gas, diarrhea, bloating, and weight loss.
Possible gastrointestinal etiologies of unexplained weight loss include: celiac disease, peptic ulcer disease, inflammatory bowel disease (crohn's disease and ulcerative colitis), pancreatitis, gastritis, diarrhea and many other GI conditions.