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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Common causes include neuromuscular diseases , such as spinal cord atrophy , multiple sclerosis ( disease that affects the brain and spinal cord causing weakness , coordination , balance difficulties , and other problems ) , amyotrophic lateral sclerosis ( ALS , also known as Lou Gehrig âs disease ; a severe neuromuscular disease that causes muscle ...