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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
1 Motor neuron diseases--a group of progressive, degenerative nerve disorders that includes amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease)  Diseases of the neuromuscular junction such as myasthenia gravis, a chronic but highly treatable condition causing weakness in the voluntary muscles.