In summary, we have shown the inhibitory effects of Bcl-2 family on the ceramide-mediated apoptotic pathway in glioma cells. Bcl-2 is considered to act not only downstream of ceramide to inhibit cytochrome c release followed by caspase activation, but also upstream of or at SMase to prevent ceramide generation.igure 3 Effects of Bcl-2 or Bax overexpression on ceramide formation and neutral sphingomyelinase activation in etoposide-treated C6 cells. C6/Neo (), C6/Bcl-2 (), and C6/Bax () cells were treated with 40 M etoposide for indicated periods.
Hawaii, which has the highest-paid waiters and waitresses in the country (mean wage: $13.91/hour) has a minimum wage of $7.00 for tipped employees.
Since most of your pay will likely come from tips, the better a server you are, the more money you'll make. But on average, waiters and waitresses make $7.14 an hour. The minimum a restaurant can pay you is $2.13 an hour - the rest of your pay will come from tips. However, if you score a job in a busy, expensive restaurant, you can make upwards of $20 an hour on a good night.