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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Studies have shown that maintaining sufficient levels of Vitamins B3, B5, B6, B9 and B12 particularly help in achieving good sleep. Among other affects, the group of B Vitamins is involved in regulating the body's level of tryptophan, an amino acid important for maintaining healthy sleep (covered later).