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Answer Wiki. Summary: peak running performance after donating blood may be impacted for up to 1-2 weeks after donating 1 pint of blood, but is most noticeably impacted within the first 1-2 days after donating when attempting to perform at peak levels during endurance activities.
General Exercise. The American Red Cross suggests that blood donors wait at least five hours after their appointment to participate in strenuous exercise or heavy lifting. Based on this suggestion, you may be able to participate in some light to moderate aerobic activity shortly after donating.