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1 Epstein-Barr virus (EBV) is a contagious infection that causes infectious mononucleosis. 2  The illness is spread by casual contact, usually via saliva. 3  Mono has an incubation period of 4 to 6 weeks. The illness is spread by casual contact, usually via saliva. 2  Mono has an incubation period of 4 to 6 weeks. 3  The vast majority of adults have antibodies against EBV, meaning they have been infected with the virus and are immune to mono.
Live EBV is in the saliva for 6 months or more immediately after mono. But EBV remains in the body for the rest of the life. It reappears in the saliva periodically throughout life. On any given day, about 1 in 4 people who once had mono will have EBV in their saliva.