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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
The brain cycles through five distinct phases during sleep: stages 1, 2, 3, 4, and rapid eye movement (REM) sleep. REM sleep makes up about 25% of your sleep cycle and first occurs about 70 to 90 minutes after you fall asleep. Because your sleep cycle repeats, you enter REM sleep several times during the night. During REM sleep, your brain and body are energized and dreaming occurs.