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Plymouth was colder, whereas Jamestown was warmer and more humid, and therefore more prone to harbor diseases. I'm sure that there were a lot more differences, but those are the big ones that leapt into my mind.
Jamestown was the first permanent English settlement in North America. It was founded in 1607 and served as the capital of the Virginia colony for over 80 years. Setting Sail for America. In 1606, King James I of England gave the Virginia Company of London the charter to establish a new colony in North America.