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1 Achalasia. 2  Achalasia is a condition that affects the smooth muscle portion of the esophagus, that is, the lower esophagus and the lower esophageal sphincter. 3  Specifically, the peristaltic wave disappears, and the lower sphincter does not relax.
Some of the most common diseases and disorders of the muscular system include myopathies, chronic fatigue syndrome, fibromyalgia, muscular dystrophy and compartment syndrome. Muscular system diseases are often caused by problems with the central nervous system. Myopathies Myopathies are muscle diseases that affect skeletal muscles and are caused by genetic problems or metabolic disorders according to the Neurology Channel.