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1 Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.3  People beginning treatment with a new antidepressant may feel drowsier than usual for the first couple of weeks. Serotonin is a chemical that affects mood, emotion, sleep and appetite. 2  Many antidepressants affect the amount of serotonin in the brain, and can also affect a personâs sleep.
Now, research on marijuana and sleep helps explain why. Besides easing insomnia, marijuana seems to have a wide range of effects on sleep. This is because chemicals in marijuana, known as cannabinoids, actually mimic the activity of chemicals found naturally in the brain.ow, research on marijuana and sleep helps explain why. Besides easing insomnia, marijuana seems to have a wide range of effects on sleep. This is because chemicals in marijuana, known as cannabinoids, actually mimic the activity of chemicals found naturally in the brain.