In summary, we have shown the inhibitory effects of Bcl-2 family on the ceramide-mediated apoptotic pathway in glioma cells. Bcl-2 is considered to act not only downstream of ceramide to inhibit cytochrome c release followed by caspase activation, but also upstream of or at SMase to prevent ceramide generation.igure 3 Effects of Bcl-2 or Bax overexpression on ceramide formation and neutral sphingomyelinase activation in etoposide-treated C6 cells. C6/Neo (), C6/Bcl-2 (), and C6/Bax () cells were treated with 40 M etoposide for indicated periods.
Hawaii, which has the highest-paid waiters and waitresses in the country (mean wage: $13.91/hour) has a minimum wage of $7.00 for tipped employees.
Two of the highest-paying areas for waiters and waitresses are Salinas and Seattle. But even though they earn a combination of hourly wages and tips, waiters and waitresses donât make much money. According to the BLS, servers earned an average hourly wage of $10.40, or about $21,640 for the year. They made a median salary of $18,730 in 2014. The highest-paid earned more than $31,930, and the lowest-paid made less than $16,470.