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A cloture is a method for ending a debate and taking a vote. In the  U.S., invoking cloture requires a three-fifths vote of the entire  Senate.
One example of the constitutional or nuclear option revolves on the argument that, on the first day of a new Congress, Senate rules, including Rule XXII, the cloture rule, do not yet apply, and thus can be changed by majority vote. Under this argument, debate could be stopped by majority vote as well.