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Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids.By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.ile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any bile acids bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.
Bile Functions. Bile does not contain enzymes like other secretions from the gastrointestinal tract. Instead it has bile salts (acids) which can 1  : Emulsify fats and break it down into small particles. 2  This is a detergent-like action of bile. 3  Helps the body absorb the breakdown products of fat in the gut.4  Bile salts bind with lipids to form micelles.ile Salts. Bile salts are constantly recycled in the body. It is secreted into the duodenum along with other compounds as bile. It binds with lipids to form micelles and eventually reenters the blood stream. By passing through the portal cirulation, bile salts enter the liver.