In the 1946 elections to the Indian constituent assembly, the Congress lost the Muslim vote to the Muslim League; it reluctantly accepted the partition of the Indian subcontinent and the formation of the state of Pakistan. After partition the Congress, as the largest party, governed India under Nehru's leadership.
ACTH is a hormone produced in the anterior pituitary gland that stimulates the adrenal glands to release cortisol, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and aldosterone.
Conversely, deficiency of ACTH is a cause of secondary adrenal insufficiency, often as a result of hypopituitarism. ACTH is also related to the circadian rhythm in many organisms. In addition to its endogenous role, ACTH is used clinically as a diagnostic agent in assessing adrenal function.