Self medication of nutrient supplements, herbal and chemical pills have been pre-viously reported from different countries and this problem has been remained among less developed countries.[@ref1][@ref2] There are also some reports regarding the self medication and drugs storage in Iran.[@ref3][@ref4] Therefore, determining the knowledge and practice of people in this regard might be important for preparing the educational interventions. The present study was conducted in 2009 aimed to determine the knowledge and practice regarding the self me-dication among women of Isfahan based on Health Belief Model (HBM). This was a cross-sectional study in Isfahan on 385 women who referred to the health centers. Since women can interfere with self-medication in the family, we chose this group. Women could affect on their family health behaviors and; therefore, focus-ing on this group is important in the health system researches. The stratified random sam-pling method was used for determining the samples of the present study. Therefore, we considered women from all parts of Isfahan in different regions and we selected samples from the entire regions in different health centers in Isfahan. One health center was randomly cho-sen from each region. For assessing the know-ledge, attitude and practice a related research-ers-made questionnaire was used in the present study. The validity and reliability of the questionnaire was assessed. This question-naire included four parts. The parts included questions regarding the demographic characte-ristics (12 questions), knowledge and practice (12 questions), questions regarding the report-ing of self medication (14 questions) and HBM structures including perceived severity, sensi-tivity and benefits and barriers (5 questions for each part). In knowledge section, one score was allocated for each correct answer. The score for wrong answers was zero. Regarding the HBM structures, a range of 0-4 score was considered for different items. At last, the score of each subject was calculated from 100. Ac-cording to the results, 86 percent of the women had experienced self-medication at least in one disease during the past 6 months. The major cause for self-medication had been previous experience and the simple availability of the medications. The main reason for avoiding self-medication was fear of the side effects. The mean score of knowledge in this regard, was 82.9 ± 13.8 and the mean score regarding the perceived susceptibility was 72.4 ± 17.1. The scores related to perceived severity and bene-fits were 71.6 ± 14.7 and 68.2 ± 17.1 respective-ly. However, the score for barriers was 61.6 ± 19.6. The mean of the HBM structures in the present study was high comparing with other studies.[@ref5] The mean score of the perceived severity and also perceived sensitivity was also high in the present study which showed that women believe that self-medication was not an appropriate method for treating different dis-eases. Therefore, it seems that preparing edu-cational programs focused on barriers' struc-ture and improving the perceived benefits may be helpful in reducing the self-medication rate among women. Educational programs should inform all the women regarding the side ef-fects of the medications. Our previous study revealed that HBM could be a suitable model for educating patients.[@ref6] The results of the mentioned study confirmed that education based on this model had beneficial effects for diabetic patients[@ref6] and the present study showed anoth-er benefit of this model for health promotion.

This was a research project by Isfahan Univer-sity of Medical Sciences, Isfahan, Iran (Re-search Project Number: 187109).
