Antitumour activity of 1-naphthol against L1210 leukaemia in vivo and Ehrlich ascites tumour cells in vivo and in vitro.
1-Naphthol inhibited ascitic fluid formation in mice infected intraperitoneally with either L1210 leukaemia or Ehrlich ascites tumour cells (EATC). A significant increase in life span was observed in EATC but not in L1210 bearing mice dosed with 1-naphthol (50-60 mg/kg). 1-Naphthol caused a concentration-dependent toxicity to EATC in vitro.