I understand that Trump is proposing to defund the Appalachian Regional Commission, charged with trying to figure out how to bring jobs to these out-of-the-way places.  With the economy now at full employment in much of the country, the only deep pockets of unemployed remaining are in Appalachia, but bringing jobs there is a heavy lift, given that they are so far off the highway grid, perhaps even the phone and internet grid, and their residents' skills set needs refreshing.  I can recall when the anthracite mines in NE PA closed in the 1950s, the miners and their families moved to where the jobs were, in SE PA.  Sad to say, that solution is what's needed now.