<Now a Missouri State Senator is saying she hopes the President is assassinated.>
This is not hard. Senator Chappelle-Nadal should resign. If she refuses to resign, she should be removed by whatever process the State of Missouri uses for that purpose. More, she should be investigated by the Secret Service and the FBI, and if her remarks can be construed as a threat, she should be prosecuted to the full extent of the law. A threat on the life and safety of the President of the United States constitutes a threat to the United States itself. It is never justified.
None of that changes or mitigates the fact that the current POTUS is a racist and a misogynist who embodies in his person a unique combination of corruption, incompetence and mental/emotional stability. Resistance to his presidency remains a moral imperative.  The Constitution provides the framework -- it protects the rights and assigns the duties for all of the actors -- within which we carry out the resistance.