DEmmal, there are currently some clinical trials that are having very good results with Ketamine....and even LSD, Magic mushrooms and MDMA, I believe, with regard to severe and resistant depression. Electro-shock, too, all of which you might already know about and may have tried, but I was distressed to read your post and want to encourage you to keep looking. Meditation and mindfulness can also help a lot. There is a great book called "Full Catastrophe Living" by Jon Kabat-Zinn. Also, I just watched a doc on Netflix called "I Am Not Your Guru" about Tony Robins and a five-day program he offers called Date With Destiny that has apparently helped people with suicidal depression. A yoga/meditation retreat can do wonders too. Or an immersive volunteer experience abroad - in nature, with animals, which are so healing. These might be options too. And telling the people you love. If you have nothing left to lose, consider a radical change...and see what happens! I wish you well, I really do!