I think there are a few people in or near Trump's inner circle (you mentioned some of them) who have some integrity, and a few more at the circle just beyond the inner circle (Kelly, Mattis).  I think people like that are going to be experiencing profound personal crises; maybe some of them already are.  They will come to a crisis, literally to a turning point: Will they place love of country above loyalty to Trump or to the party? Will they be able to serve the country and the president at the same time?  How can they calculate the harm done by continuing to work for him against the harm done by stepping down?  What are they willing to risk to do the right thing?  How much will their families suffer?