Toxic relationships create stress and anxiety which triggers the flight/fight chemical reactions in the body - high levels of cortisol and adrenaline.  Some people eventually see an aggregate effect of this, whether its the result of metabolizing this toxic soup - depression, schizophrenia, or nerve damage - literally from damage to the myelin nerve coatings.  The B's help particularly Niacin/B6 in protecting the nervous system. Best fix? Remove  yourself from the source of the anxiety/fear/dysfunction - see divorce from your toxic boss, workplace, war zone, family, partner or other... Social creates chemical, creates internal injury.  It's not a character flaw in the sufferer, usually more in the adjacent situation.