It found MODERATE EVIDENCE for Risks/Harms:

• Increased risk of overdose injuries, including respiratory distress, among pediatric populations in U.S. states where cannabis is legal.

• The impairment in the cognitive domains of learning, memory, and attention (acute cannabis use).

• Increased symptoms of mania and hypomania in individuals diagnosed with bipolar disorders (regular cannabis use).

• A small increased risk for the development of depressive disorders.

• Increased incidence of suicidal ideation and suicide attempts with a higher incidence among heavier users.

• Increased incidence of suicide completion.

• Increased incidence of social anxiety disorder (regular cannabis use).

• Worsening of negative symptoms of schizophrenia (e.g., blunted affect) among individuals with psychotic disorders.

• The development of substance dependence and/or substance abuse disorder for substances including alcohol, tobacco, and other illicit drugs (any cannabis use).