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TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The results of mediation analyses do not support a model of @CHEM-GENE$ being a prominent mediator in the link between childhood trauma and BPD. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Thus, the findings indicate dysregulations in the @CHEM-GENE$ system of patients diagnosed with BPD with more longitudinal research being necessary to disentangle the relationship between childhood adversities, oxytocin system, and psychopathology. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Thus, the findings indicate dysregulations in the @CHEMICAL$ system of patients diagnosed with BPD with more longitudinal research being necessary to disentangle the relationship between childhood adversities, @GENE$ system, and psychopathology. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Thus, the findings indicate dysregulations in the @CHEMICAL$ system of patients diagnosed with BPD with more longitudinal research being necessary to disentangle the relationship between childhood adversities, @GENE$ system, and psychopathology. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Thus, the findings indicate dysregulations in the oxytocin system of patients diagnosed with BPD with more longitudinal research being necessary to disentangle the relationship between childhood adversities, @CHEM-GENE$ system, and psychopathology. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ genes encode mitochondrial enzymes capable of metabolizing acetaldehyde and other biological @GENE$ in the body. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ genes encode mitochondrial enzymes capable of metabolizing @GENE$ and other biological aldehydes in the body. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$, another mitochondrial enzyme sharing 72% identity with ALDH2, is also capable of metabolizing @GENE$ but has a tissue distribution and pattern of activity distinct from that of ALDH2. | CPR:9 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Mammalian ALDH1B1, another mitochondrial enzyme sharing 72% identity with @CHEMICAL$, is also capable of metabolizing @GENE$ but has a tissue distribution and pattern of activity distinct from that of ALDH2. | CPR:9 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Mammalian ALDH1B1, another mitochondrial enzyme sharing 72% identity with ALDH2, is also capable of metabolizing @CHEMICAL$ but has a tissue distribution and pattern of activity distinct from that of @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Bioinformatic analyses of several vertebrate genomes were undertaken using known @CHEMICAL$ and ALDH1B1 @GENE$ sequences. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Bioinformatic analyses of several vertebrate genomes were undertaken using known ALDH2 and @CHEMICAL$ @GENE$ sequences. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Here we report that @CHEMICAL$ null mice are lean and protected from diet-induced obesity and @GENE$ intolerance. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on @GENE$ by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ (ASA) and other non-steroidal anti-inflammatory drugs, which are @GENE$ (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (@GENE$) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in @CHEMICAL$-intolerant patients, while sodium salicylate, hardly active on @GENE$ by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are @CHEMICAL$ (COX) inhibitors, precipitate asthmatic attacks in @GENE$-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (@CHEMICAL$) inhibitors, precipitate asthmatic attacks in @GENE$-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while @CHEMICAL$, hardly active on @GENE$ by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are @CHEMICAL$ (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while @GENE$, hardly active on COX by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (@CHEMICAL$) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while @GENE$, hardly active on COX by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-@CHEMICAL$ anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on @GENE$ by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-@CHEMICAL$ anti-inflammatory drugs, which are @GENE$ (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (ASA) and other non-@CHEMICAL$ anti-inflammatory drugs, which are cyclooxygenase (@GENE$) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (@CHEMICAL$) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on @GENE$ by itself, is well tolerated by these patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (@CHEMICAL$) and other non-steroidal anti-inflammatory drugs, which are @GENE$ (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Aspirin (@CHEMICAL$) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (@GENE$) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: However, @CHEMICAL$ moiety appears to interfere with aspirin inhibitory action on platelets and vascular @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: However, salicylate moiety appears to interfere with @CHEMICAL$ inhibitory action on platelets and vascular @GENE$. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Although the precise mechanism of the protective action of @CHEMICAL$ is unknown, our data support the possibility of interaction between salicylate and ASA on @GENE$ locus in the respiratory tract in ASA-intolerant patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Although the precise mechanism of the protective action of trilisate is unknown, our data support the possibility of interaction between @CHEMICAL$ and ASA on @GENE$ locus in the respiratory tract in ASA-intolerant patients. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Although the precise mechanism of the protective action of trilisate is unknown, our data support the possibility of interaction between salicylate and @CHEMICAL$ on @GENE$ locus in the respiratory tract in ASA-intolerant patients. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Although the precise mechanism of the protective action of trilisate is unknown, our data support the possibility of interaction between salicylate and ASA on @CHEMICAL$ locus in the respiratory tract in @GENE$-intolerant patients. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ inhibits @GENE$ release and delays progression of amyotrophic lateral sclerosis in mice. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It inhibits the activity of caspase-1, caspase-3, inducible form of @CHEMICAL$ synthetase (iNOS) and @GENE$ mitogen-activated protein kinase (MAPK). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It inhibits the activity of caspase-1, caspase-3, inducible form of @CHEMICAL$ synthetase (iNOS) and p38 @GENE$ (MAPK). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It inhibits the activity of caspase-1, caspase-3, inducible form of @CHEMICAL$ synthetase (iNOS) and p38 mitogen-activated protein kinase (@GENE$). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It inhibits the activity of @CHEMICAL$, caspase-3, inducible form of @GENE$ synthetase (iNOS) and p38 mitogen-activated protein kinase (MAPK). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It inhibits the activity of caspase-1, @CHEMICAL$, inducible form of @GENE$ synthetase (iNOS) and p38 mitogen-activated protein kinase (MAPK). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It inhibits the activity of caspase-1, caspase-3, @CHEM-GENE$ (iNOS) and p38 mitogen-activated protein kinase (MAPK). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It inhibits the activity of caspase-1, caspase-3, inducible form of @CHEMICAL$ synthetase (@GENE$) and p38 mitogen-activated protein kinase (MAPK). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: We find that @CHEMICAL$ inhibits mitochondrial permeability-transition-mediated @GENE$ release. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$-mediated inhibition of @GENE$ release is demonstrated in vivo, in cells, and in isolated mitochondria. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Heterogeneous expression and polymorphic genotype of @CHEM-GENE$ in human lung. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: BACKGROUND: @CHEMICAL$ (GSTs) are involved in the detoxification of xenobiotics by conjugation with @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: BACKGROUND: Glutathione S-transferases (@CHEMICAL$) are involved in the detoxification of xenobiotics by conjugation with @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: BACKGROUND: @CHEM-GENE$ (GSTs) are involved in the detoxification of xenobiotics by conjugation with glutathione. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: BACKGROUND: @CHEMICAL$ S-transferases (@GENE$) are involved in the detoxification of xenobiotics by conjugation with glutathione. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEM-GENE$ inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ inhibition-induced changes in plasma @GENE$ levels, anxiety and locomotor activity in male CD1 mice. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Here we studied the effects of the recently developed @CHEM-GENE$ inhibitor JZL184 on basal and stress-induced corticosterone levels in male CD1 mice, and found that this compound dramatically increased basal levels without affecting stress responses. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Here we studied the effects of the recently developed @CHEMICAL$ inhibitor @GENE$ on basal and stress-induced corticosterone levels in male CD1 mice, and found that this compound dramatically increased basal levels without affecting stress responses. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Here we studied the effects of the recently developed @CHEMICAL$ inhibitor JZL184 on basal and stress-induced @GENE$ levels in male CD1 mice, and found that this compound dramatically increased basal levels without affecting stress responses. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These findings show that @CHEM-GENE$ inhibition dramatically increases basal levels of corticosterone. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These findings show that @CHEMICAL$ inhibition dramatically increases basal levels of @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: This endocrine effect partly affects the anxiolytic, but not the locomotion-enhancing effects of @CHEM-GENE$ blockade. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Induction of the liver cancer-down-regulated long noncoding RNA @CHEMICAL$ mediates @GENE$-induced apoptosis of liver cancer cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Considerable attention has focused on the antitumor effect of @CHEMICAL$ inhibitor (@GENE$, TSA) as well as the coding gene expression-induced apoptosis of cancer cells. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Considerable attention has focused on the antitumor effect of @CHEMICAL$ inhibitor (Trichostatin A, @GENE$) as well as the coding gene expression-induced apoptosis of cancer cells. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Among these differentially expressed lncRNAs, the greatest change was noted for @CHEMICAL$, which had more than 300 folds induction upon @GENE$ treatment. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ selectively induced @GENE$ in four studied HCC cell lines. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The @CHEMICAL$-induced @GENE$ expression was positively correlated with the apoptotic effect of TSA in HCC cells. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The TSA-induced @CHEMICAL$ expression was positively correlated with the apoptotic effect of @GENE$ in HCC cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: In addition, knockdown the expression of @CHEMICAL$ significantly reduced @GENE$-induced apoptosis of Huh7cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Therefore, @CHEMICAL$-induced apoptosis of HCC cells is @GENE$ dependent and reduced expression of uc002mbe.2 may be associated with liver carcinogenesis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Therefore, @CHEMICAL$-induced apoptosis of HCC cells is uc002mbe.2 dependent and reduced expression of @GENE$ may be associated with liver carcinogenesis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The mannose 6-phosphate-binding sites of @CHEMICAL$/@GENE$ determine its capacity to suppress matrix invasion by squamous cell carcinoma cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The @CHEMICAL$-binding sites of M6P/@GENE$ determine its capacity to suppress matrix invasion by squamous cell carcinoma cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The @CHEMICAL$ (mannose 6-phosphate)/@GENE$ (insulin-like growth factor II receptor) interacts with a variety of factors that impinge on tumour invasion and metastasis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The @CHEMICAL$ (mannose 6-phosphate)/IGF2R (@GENE$) interacts with a variety of factors that impinge on tumour invasion and metastasis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The M6P (@CHEMICAL$)/@GENE$ (insulin-like growth factor II receptor) interacts with a variety of factors that impinge on tumour invasion and metastasis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The M6P (@CHEMICAL$)/IGF2R (@GENE$) interacts with a variety of factors that impinge on tumour invasion and metastasis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: It has been shown that expression of wild-type @CHEMICAL$/@GENE$ reduces the tumorigenic and invasive properties of receptor-deficient SCC-VII squamous cell carcinoma cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: We have now used mutant forms of @CHEMICAL$/@GENE$ to assess the relevance of the different ligand-binding sites of the receptor for its biological activities in this cellular system. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The results of the present study demonstrate that @CHEMICAL$/@GENE$ does not require a functional binding site for insulin-like growth factor II for inhibition of anchorage-independent growth and matrix invasion by SCC-VII cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The results of the present study demonstrate that @CHEMICAL$/IGF2R does not require a functional binding site for @GENE$ for inhibition of anchorage-independent growth and matrix invasion by SCC-VII cells. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These findings highlight that the interaction between @CHEMICAL$/@GENE$ and M6P-modified ligands is not only important for intracellular accumulation of lysosomal enzymes and formation of dense lysosomes, but is also crucial for the ability of the receptor to suppress SCC-VII growth and invasion. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: These findings highlight that the interaction between M6P/@CHEMICAL$ and @GENE$-modified ligands is not only important for intracellular accumulation of lysosomal enzymes and formation of dense lysosomes, but is also crucial for the ability of the receptor to suppress SCC-VII growth and invasion. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The present study also shows that some of the biological activities of @CHEMICAL$/@GENE$ in SCC-VII cells strongly depend on a functional M6P-binding site within domain 3, thus providing further evidence for the non-redundant cellular functions of the individual carbohydrate-binding domains of the receptor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The present study also shows that some of the biological activities of M6P/@CHEMICAL$ in SCC-VII cells strongly depend on a functional @GENE$-binding site within domain 3, thus providing further evidence for the non-redundant cellular functions of the individual carbohydrate-binding domains of the receptor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The present study also shows that some of the biological activities of M6P/@CHEMICAL$ in SCC-VII cells strongly depend on a functional M6P-binding site within domain 3, thus providing further evidence for the non-redundant cellular functions of the individual @GENE$-binding domains of the receptor. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$, a new @GENE$ inhibitor for the management of obesity. | CPR:4 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ treatment also results in modest improvements in total cholesterol, @GENE$, blood pressure, and fasting glucose and insulin concentrations. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ treatment also results in modest improvements in total cholesterol, low-density lipoprotein, blood pressure, and fasting glucose and @GENE$ concentrations. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Orlistat treatment also results in modest improvements in total @CHEMICAL$, @GENE$, blood pressure, and fasting glucose and insulin concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Orlistat treatment also results in modest improvements in total @CHEMICAL$, low-density lipoprotein, blood pressure, and fasting glucose and @GENE$ concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Orlistat treatment also results in modest improvements in total cholesterol, @CHEMICAL$, blood pressure, and fasting @GENE$ and insulin concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Orlistat treatment also results in modest improvements in total cholesterol, low-density lipoprotein, blood pressure, and fasting @CHEMICAL$ and @GENE$ concentrations. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: In the AG+GG group, males with @CHEMICAL$ @GENE$ levels <40 mg/dL are less frequent (P = 0.05) and obesity tends to be less prevalent (P = 0.07). | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Evidence has accumulated in the last few years that the expression of the microsomal/peroxidase antigen (M/TPO-Ag) in thyroid cells is induced by @CHEMICAL$, through pathways which involve intracellular @GENE$ accumulation and protein synthesis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Evidence has accumulated in the last few years that the expression of the microsomal/peroxidase antigen (@CHEMICAL$) in thyroid cells is induced by TSH, through pathways which involve intracellular @GENE$ accumulation and protein synthesis. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Evidence has accumulated in the last few years that the expression of the @CHEMICAL$ (M/TPO-Ag) in thyroid cells is induced by TSH, through pathways which involve intracellular @GENE$ accumulation and protein synthesis. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: @CHEMICAL$ and @GENE$ also increase the levels of the specific mRNA for TPO in thyroid cells from different species. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: TSH and @CHEMICAL$ also increase the levels of the specific mRNA for @GENE$ in thyroid cells from different species. | CPR:3 |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The modulation of M/TPO-Ag surface expression by @CHEMICAL$ can explain the decrease of circulating anti-MAb observed during @GENE$ therapy in hypothyroid patients with Hashimoto's thyroiditis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: The modulation of @CHEMICAL$ surface expression by TSH can explain the decrease of circulating anti-MAb observed during @GENE$ therapy in hypothyroid patients with Hashimoto's thyroiditis. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Other agents, such as @CHEMICAL$ and sodium iodide, which influence thyroid cell function, do not directly interfere with the expression of @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Other agents, such as methimazole and @CHEMICAL$, which influence thyroid cell function, do not directly interfere with the expression of @GENE$. | false |
TASK: the task is to classify relations between a chemical and a gene for a sentence.
INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence.
OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters:
CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR
CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR
CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR
CPR:6, which includes ANTAGONIST
CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF
false, which indicates no relations
The following examples are provided:
Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin.
Example-1 A: false
Q: Saccharomyces cerevisiae t55, a subunit of the RNA polymerase III-specific general transcription factor TFIIIC, comprises an @CHEM-GENE$ (t55-HPD) whose catalytic activity and cellular function is poorly understood. | false |