cdcvd/ejpfepj · Datasets at Hugging Face

tags sequencelengths 2 166	tokens sequencelengths 2 166
[ 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Ara-C", "activated", "JNKs", "only", "after", "prolonged", "incubation", "(", "90-120", "minutes", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 7, 8, 0 ]	[ "Thus", ",", "ceramide", "is", "not", "a", "positive", "signal", "for", "ERK", "activation", "in", "T-cell", "lines", "." ]
[ 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "The", "effects", "of", "Ara-C", "on", "JNK", "activity", "may", "be", "mediated", "through", "secondary", "response", "pathways", "." ]
[ 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0 ]	[ "Comparative", "analysis", "identifies", "conserved", "tumor", "necrosis", "factor", "receptor-associated", "factor", "3", "binding", "sites", "in", "the", "human", "and", "simian", "Epstein-Barr", "virus", "oncogene", "LMP1", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Nonhuman", "primates", "are", "naturally", "infected", "with", "a", "B-lymphotropic", "herpesvirus", "closely", "related", "to", "Epstein-Barr", "virus", "(", "EBV", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "These", "simian", "EBV", "share", "considerable", "genetic", ",", "biologic", ",", "and", "epidemiologic", "features", "with", "human", "EBV", ",", "including", "virus-induced", "tumorigenesis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "However", ",", "latent", ",", "transformation-associated", "viral", "genes", "demonstrate", "marked", "sequence", "divergence", "among", "species", "despite", "the", "conserved", "functions", "." ]
[ 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "We", "have", "cloned", "the", "latent", "membrane", "protein", "1", "(", "LMP1", ")", "homologs", "from", "the", "simian", "EBV", "naturally", "infecting", "baboons", "(", "cercopithicine", "herpesvirus", "12", ",", "herpesvirus", "papio", ")", "and", "rhesus", "monkeys", "(", "cercopithicine", "herpesvirus", "15", ")", "for", "a", "comparative", "study", "with", "the", "human", "EBV", "oncogene", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 5, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 0, 0 ]	[ "The", "transmembrane", "domains", "are", "well", "conserved", ",", "but", "there", "is", "striking", "sequence", "divergence", "of", "the", "carboxy-terminal", "cytoplasmic", "domain", "essential", "for", "B-cell", "immortalization", "and", "interaction", "with", "the", "tumor", "necrosis", "factor", "receptor", "signaling", "pathway", "." ]
[ 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 0, 5, 6, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 0, 0, 5, 6, 6, 0 ]	[ "Nevertheless", ",", "the", "simian", "EBV", "LMP1s", "retain", "most", "functions", "in", "common", "with", "EBV", "LMP1", ",", "including", "the", "ability", "to", "induce", "NF-", "(", "kappa", ")", "B", "activity", "in", "human", "cells", ",", "to", "bind", "the", "tumor", "necrosis", "factor-associated", "factor", "3", "(", "TRAF3", ")", "in", "vitro", ",", "and", "to", "induce", "expression", "of", "tumor", "necrosis", "factor-responsive", "genes", ",", "such", "as", "ICAM1", ",", "in", "human", "B", "lymphocytes", "." ]
[ 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0 ]	[ "Multiple", "TRAF3", "binding", "sites", "containing", "a", "PXQXT/S", "core", "sequence", "can", "be", "identified", "in", "the", "simian", "EBV", "LMP1s", "by", "an", "in", "vitro", "binding", "assay", "." ]
[ 0, 1, 2, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 3, 0, 0, 0 ]	[ "A", "PXQXT/S-containing", "sequence", "is", "also", "present", "in", "the", "cytoplasmic", "domain", "of", "the", "Hodgkin", "'s", "disease", "marker", ",", "CD30", ",", "and", "binds", "TRAF3", "in", "vitro", "." ]
[ 0, 3, 4, 4, 4, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]	[ "The", "last", "13", "amino", "acids", "containing", "a", "PXQXT/S", "sequence", "are", "highly", "conserved", "in", "human", "and", "simian", "EBV", "LMP1", "but", "do", "not", "bind", "TRAF3", ",", "suggesting", "a", "distinct", "role", "for", "this", "conserved", "region", "of", "LMP1", "." ]
[ 0, 0, 1, 2, 2, 0, 3, 0, 0, 3, 4, 4, 4, 4, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "The", "conserved", "TRAF3", "binding", "sites", "in", "LMP1", "and", "the", "CD30", "Hodgkin", "'s", "disease", "marker", "provides", "further", "evidence", "that", "a", "TRAF3", "-mediated", "signal", "transduction", "pathway", "may", "be", "important", "in", "malignant", "transformation", "." ]
[ 1, 2, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0 ]	[ "Chromosome", "1", "aneusomy", "with", "1p36", "under-representation", "is", "related", "to", "histologic", "grade", ",", "DNA", "aneuploidy", ",", "high", "c-erb", "B-2", "and", "loss", "of", "bcl-2", "expression", "in", "ductal", "breast", "carcinoma", "." ]
[ 1, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0 ]	[ "Chromosome", "1", "abnormalities", "with", "loss", "of", "1p36", "have", "been", "investigated", "in", "95", "breast-cancer", "samples", "by", "means", "of", "a", "dual-target", "fluorescence", "in-situ", "hybridization", "(", "FISH", ")", "technique", "using", "the", "pUC", "1.77", "and", "p1-79", "probes", ",", "specific", "for", "the", "1q12", "and", "1p36", "regions", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Abnormalities", "for", "one", "or", "both", "probes", "were", "detected", "in", "83/95", "samples", "." ]
[ 0, 1, 0, 0, 0, 0, 0, 0 ]	[ "Relative", "1p36", "under-representation", "was", "found", "in", "79/95", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "The", "clinical", "relevance", "of", "these", "alterations", "was", "studied", "by", "comparing", "the", "FISH", "results", "with", "several", "parameters", "currently", "used", "in", "breast-cancer", "pathology", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Distinct", "patterns", "of", "chromosome", "1", "abnormalities", "were", "found", "among", "the", "histologic", "types", "of", "breast", "carcinoma", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0 ]	[ "Lobular", "or", "mucinous", "samples", "showed", "few", "or", "no", "alterations", ",", "whereas", "most", "ductal", "samples", "had", "high", "chromosome", "1", "polysomy", "with", "under-representation", "of", "1p36", "." ]
[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]	[ "In", "ductal", "carcinomas", ",", "chromosome", "1", "alterations", "increased", "with", "histologic", "grade", ",", "DNA", "aneuploidy", ",", "loss", "of", "bcl-2", "and", "high", "c-erb", "B-2", "expression", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "These", "associations", "were", "found", "to", "be", "statistically", "significant", "." ]
[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0 ]	[ "No", "correlation", "between", "chromosome", "1", "alterations", "and", "nuclear", "grade", ",", "age", ",", "size", ",", "lymph-node", "involvement", ",", "hormonal", "receptor", "presence", ",", "proliferation", "activity", "or", "p53", "protein", "expression", "was", "detected", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "These", "results", "indicate", "the", "utility", "of", "this", "FISH", "technique", "for", "a", "better", "definition", "of", "the", "biological", "characteristics", "of", "ductal", "carcinomas", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 0, 0, 5, 6, 0 ]	[ "G", "(", "Anh", ")", "MTetra", ",", "a", "natural", "bacterial", "cell", "wall", "breakdown", "product", ",", "induces", "interleukin-1", "beta", "and", "interleukin-6", "expression", "in", "human", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "A", "study", "of", "the", "molecular", "mechanisms", "involved", "in", "inflammatory", "cytokine", "expression", "[", "published", "erratum", "appears", "in", "J", "Biol", "Chem", "1994", "Jun", "17", ";", "269", "(", "24", ")", ":", "16983", "]" ]
[ 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "It", "is", "believed", "that", "induction", "of", "cytokine", "expression", "by", "bacterial", "cell", "wall", "components", "plays", "a", "role", "in", "the", "development", "and", "course", "of", "sepsis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "However", ",", "most", "attention", "has", "been", "focused", "on", "lipopolysaccharide", "(", "LPS", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 3, 0, 0, 5, 6, 0 ]	[ "We", "studied", "the", "ability", "of", "N-acetylglucosaminyl-1", ",", "6-anhydro-N-acetylmuramyl-L-alanyl-D-", "isoglutamyl-m-diaminopimelyl-D-alanine", "(", "G", "(", "Anh", ")", "MTetra", ")", ",", "a", "naturally", "occurring", "breakdown", "product", "of", "peptidoglycan", "that", "is", "produced", "by", "soluble", "lytic", "transglycosylase", "of", "Escherichia", "coli", ",", "to", "induce", "cytokine", "expression", "in", "human", "monocytes", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 9, 10, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0 ]	[ "G", "(", "Anh", ")", "MTetra", "was", "found", "to", "strongly", "induce", "interleukin", "(", "IL", ")", "-1", "beta", "and", "IL-6", "mRNA", "expression", "after", "2", "h", "and", "IL-1", "beta", "and", "IL-6", "protein", "secretion", "after", "48", "h", "of", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "The", "increase", "in", "mRNA", "accumulation", "was", "at", "least", "partly", "due", "to", "an", "increase", "in", "the", "transcription", "rates", "of", "the", "respective", "genes", "and", "was", "accompanied", "by", "a", "strong", "induction", "of", "nuclear", "factor-kappa", "B", "and", "activator", "protein-1", "transcription", "factor", "expression", "." ]
[ 0, 0, 0, 0, 3, 4, 4, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Experiments", "using", "inhibitors", "of", "protein", "kinase", "C", ",", "protein", "kinase", "A", ",", "and", "tyrosine", "kinase-dependent", "pathways", "revealed", "that", "G", "(", "Anh", ")", "MTetra-induced", "IL-1", "beta", "and", "IL-6", "mRNA", "expression", "involves", "activation", "of", "an", "H7-inhibitable", "pathway", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]	[ "By", "using", "the", "protein", "synthesis", "inhibitor", "cycloheximide", ",", "it", "was", "shown", "that", "G", "(", "Anh", ")", "MTetra-induced", "IL-6", "mRNA", "expression", "depends", "on", "the", "synthesis", "of", "new", "protein", ",", "whereas", "G", "(", "Anh", ")", "MTetra-induced", "IL-1", "beta", "mRNA", "accumulation", "does", "not", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "When", "responses", "to", "G", "(", "Anh", ")", "MTetra", "were", "compared", "with", "those", "to", "LPS", "and", "muramyldipeptide", "(", "MDP", ")", ",", "it", "was", "found", "that", "the", "optimal", "response", "to", "G", "(", "Anh", ")", "MTetra", "induction", "was", "similar", "to", "that", "of", "LPS", "but", "significantly", "higher", "than", "the", "response", "to", "MDP", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Furthermore", ",", "maximal", "G", "(", "Anh", ")", "MTetra-induced", "IL-1", "beta", "and", "IL-6", "mRNA", "expression", "could", "be", "enhanced", "by", "co-stimulation", "with", "LPS", "or", "MDP", ",", "suggesting", "that", "different", "receptors", "and/or", "transduction", "pathways", "were", "involved", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0 ]	[ "These", "results", "indicate", "that", "G", "(", "Anh", ")", "MTetra", "induces", "IL-1", "beta", "and", "IL-6", "expression", "in", "human", "monocytes", "suggesting", "a", "possible", "role", "for", "G", "(", "Anh", ")", "MTetra", "in", "the", "release", "of", "cytokines", "during", "sepsis", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Increased", "proliferation", ",", "cytotoxicity", ",", "and", "gene", "expression", "after", "stimulation", "of", "human", "peripheral", "blood", "T", "lymphocytes", "through", "a", "surface", "ganglioside", "(", "GD3", ")", "[", "published", "erratum", "appears", "in", "J", "Immunol", "1994", "Jul", "15", ";", "153", "(", "2", ")", ":", "910", "]" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Previous", "studies", "have", "suggested", "that", "gangliosides", "have", "an", "important", "role", "in", "cell", "signaling", "and", "recognition", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "However", ",", "their", "specific", "function", "in", "these", "processes", "has", "not", "been", "clearly", "defined", "." ]
[ 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0 ]	[ "A", "mAb", ",", "R24", ",", "that", "reacts", "specifically", "with", "a", "cell", "surface", "ganglioside", "(", "GD3", ")", "has", "been", "demonstrated", "to", "stimulate", "proliferation", "of", "T", "cells", "derived", "from", "human", "peripheral", "blood", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]	[ "In", "this", "study", ",", "we", "have", "investigated", "the", "mechanisms", "by", "which", "the", "R24", "mAb", "affects", "T", "cell", "functions", "." ]
[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 0, 3, 0, 3, 0, 0, 3, 0 ]	[ "We", "have", "observed", "that", "the", "R24", "mAb", "stimulates", "GD3+", "T", "cell", "proliferation", ",", "cytotoxicity", ",", "and", "surface", "marker", "expression", "of", "IL-2R", "alpha-chain", ",", "IL-2R", "beta-chain", ",", "HLA-DR", ",", "CD11a", ",", "and", "CD11c", "." ]
[ 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0 ]	[ "Additionally", ",", "IFN-gamma", "activity", "but", "not", "IL-1", ",", "IL-2", ",", "or", "IL-4", "activity", "was", "present", "in", "culture", "supernatants", "72", "h", "after", "R24", "stimulation", "." ]
[ 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 0, 0, 0, 3, 0, 0 ]	[ "In", "some", "donors", ",", "increased", "IL-6", "and", "TNF-alpha", "activity", "also", "was", "detected", "after", "R24", "treatment", "." ]
[ 0, 0, 3, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 3, 0, 3, 0 ]	[ "Furthermore", ",", "R24", "treatment", "resulted", "in", "translocation", "of", "c-rel", ",", "but", "little", "or", "no", "NF", "kappa", "B", "p50", "or", "p65", ",", "from", "the", "cytoplasm", "to", "the", "nucleus", "and", "an", "increase", "of", "NF", "kappa", "B", "binding", "complexes", "containing", "c-rel", "and", "p50", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "This", "treatment", "also", "caused", "increased", "tyrosine", "phosphorylation", "of", "specific", "protein", "substrates", "." ]
[ 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 4, 4, 0, 0, 0, 0, 0, 3, 0, 0, 0 ]	[ "R24", "-stimulated", "increases", "in", "proliferation", ",", "cytotoxicity", ",", "and", "cell", "surface", "protein", "expression", "could", "be", "blocked", "by", "cyclosporin", "and", "staurosporin", ",", "indicating", "that", "cyclophilin/calcineurin", "and", "protein", "kinase", "C", "may", "be", "involved", "in", "the", "R24", "signaling", "pathway", "." ]
[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]	[ "Additionally", ",", "herbimycin", "A", ",", "a", "tyrosine", "kinase", "inhibitor", ",", "blocked", "the", "R24", "-stimulated", "increase", "in", "proliferation", "but", "not", "cytotoxicity", "at", "concentrations", "consistent", "with", "specificity", "for", "tyrosine", "kinases", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 3, 0 ]	[ "These", "results", "suggest", "that", "multiple", "biochemical", "pathways", "are", "involved", "in", "the", "activation", "of", "human", "T", "cells", "by", "R24", "." ]
[ 0, 0, 3, 4, 4, 0, 3, 4, 4, 0, 0, 0, 0, 0, 1, 2, 0 ]	[ "Genes", "encoding", "general", "initiation", "factors", "for", "RNA", "polymerase", "II", "transcription", "are", "dispersed", "in", "the", "human", "genome", "." ]
[ 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0 ]	[ "General", "transcription", "factors", "are", "required", "for", "accurate", "initiation", "of", "transcription", "by", "RNA", "polymerase", "II", "." ]
[ 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Human", "cDNAs", "encoding", "subunits", "of", "these", "factors", "have", "been", "cloned", "and", "sequenced", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 0, 3, 4, 0, 3, 4, 0, 3, 0, 3, 0, 0, 3, 4, 4, 0, 0, 3, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0 ]	[ "Using", "fluorescence", "in", "situ", "hybridization", "(", "FISH", ")", ",", "we", "show", "here", "that", "the", "genes", "encoding", "the", "TATA-box", "binding", "protein", "(", "TBP", ")", ",", "TFIIB", ",", "TFIIE", "alpha", ",", "TFIIE", "beta", ",", "RAP30", ",", "RAP74", "and", "the", "62", "kDa", "subunit", ",", "of", "TFIIH", "are", "located", "at", "the", "human", "chromosomal", "bands", "6q26-27", ",", "1p21-22", ",", "3q21-24", ",", "8p12", ",", "13q14", ",", "19p13.3", "and", "11p14-15.1", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "This", "dispersed", "localization", "of", "a", "group", "of", "functionally", "related", "gene", "provides", "insights", "into", "the", "molecular", "mechanism", "of", "human", "genome", "evolution", "and", "their", "possible", "involvement", "in", "human", "diseases", "." ]
[ 3, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "BCL-6", "and", "the", "molecular", "pathogenesis", "of", "B-cell", "lymphoma", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "The", "results", "presented", "identify", "the", "first", "genetic", "lesion", "associated", "with", "DLCL", ",", "the", "most", "clinically", "relevant", "form", "of", "NHL", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]	[ "Although", "no", "proof", "yet", "exists", "of", "a", "role", "for", "these", "lesions", "in", "DLCL", "pathogenesis", ",", "the", "feature", "of", "the", "BCL-6", "gene", "product", ",", "its", "specific", "pattern", "of", "expression", "in", "B", "cells", ",", "and", "the", "clustering", "of", "lesions", "disrupting", "its", "regulatory", "domain", "strongly", "suggest", "that", "deregulation", "of", "BCL-6", "expression", "may", "contribute", "to", "DLCL", "development", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 2, 0, 0, 3, 0, 0, 0, 0, 0, 0 ]	[ "A", "more", "precise", "definition", "of", "the", "role", "of", "BCL-6", "in", "normal", "and", "neoplastic", "B-cell", "development", "is", "the", "goal", "of", "ongoing", "study", "of", "transgenic", "mice", "engineered", "either", "to", "express", "BCL-6", "under", "heterologous", "promoters", "or", "lacking", "BCL-6", "function", "due", "to", "targeted", "deletions", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]	[ "In", "addition", "to", "contributing", "to", "the", "understanding", "of", "DLCL", "pathogenesis", ",", "the", "identification", "of", "BCL-6", "lesions", "may", "have", "relevant", "clinical", "implications", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "DLCL", "represent", "a", "heterogeneous", "group", "of", "neoplasms", "which", "are", "treated", "homogeneously", "despite", "the", "fact", "that", "only", "50", "%", "of", "patients", "experience", "long-term", "disease-free", "survival", "(", "Schneider", "et", "al.", "1990", ")", "." ]
[ 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "The", "fact", "that", "BCL-6", "rearrangements", "identify", "biologically", "and", "clinically", "distinct", "subsets", "of", "DLCL", "suggests", "that", "these", "lesions", "may", "be", "useful", "as", "markers", "in", "selection", "of", "differential", "therapeutic", "strategies", "based", "on", "different", "risk", "groups", "." ]
[ 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0 ]	[ "Furthermore", ",", "the", "BCL-6", "rearrangements", "can", "be", "used", "to", "identify", "and", "monitor", "the", "malignant", "clone", "with", "sensitive", "PCR-based", "techniques", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Since", "clinical", "remission", "has", "been", "observed", "in", "a", "significant", "fraction", "of", "DLCL", "cases", ",", "these", "markers", "may", "serve", "as", "critical", "tools", "for", "sensitive", "monitoring", "of", "minimal", "residual", "disease", "and", "early", "diagnosis", "of", "relapse", "(", "Gribben", "et", "al.", "1993", ")", "." ]
[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]	[ "Pancreatic", "development", "and", "maturation", "of", "the", "islet", "B", "cell", "." ]
[ 0, 0, 7, 8, 8, 0 ]	[ "Studies", "of", "pluripotent", "islet", "cultures", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Pancreas", "organogenesis", "is", "a", "highly", "regulated", "process", ",", "in", "which", "two", "anlage", "evaginate", "from", "the", "primitive", "gut", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "They", "later", "fuse", ",", "and", ",", "under", "the", "influence", "of", "the", "surrounding", "mesenchyme", ",", "the", "mature", "organ", "develops", ",", "being", "mainly", "composed", "of", "ductal", ",", "exocrine", "and", "endocrine", "compartments", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Early", "buds", "are", "characterized", "by", "a", "branching", "morphogenesis", "of", "the", "ductal", "epithelium", "from", "which", "endocrine", "and", "exocrine", "precursor", "cells", "bud", "to", "eventually", "form", "the", "two", "other", "compartments", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "The", "three", "compartments", "are", "thought", "to", "be", "of", "common", "endodermal", "origin", ";", "in", "contrast", "to", "earlier", "hypotheses", ",", "which", "suggested", "that", "the", "endocrine", "compartment", "was", "of", "neuroectodermal", "origin", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "It", "is", "thus", "generally", "believed", "that", "the", "pancreatic", "endocrine-lineage", "possesses", "the", "ability", "to", "mature", "along", "a", "differentiation", "pathway", "that", "shares", "many", "characteristics", "with", "those", "of", "neuronal", "differentiation", "." ]
[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "During", "recent", "years", ",", "studies", "of", "insulin-gene", "regulation", "and", ",", "in", "particular", ",", "the", "tissue-specific", "transcriptional", "control", "of", "insulin-gene", "activity", "have", "provided", "information", "on", "pancreas", "development", "in", "general", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0 ]	[ "The", "present", "review", "summarizes", "these", "findings", ",", "with", "a", "special", "focus", "on", "our", "own", "studies", "on", "pluripotent", "endocrine", "cultures", "of", "rat", "pancreas", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]	[ "Octamer", "independent", "activation", "of", "transcription", "from", "the", "kappa", "immunoglobulin", "germline", "promoter", "." ]
[ 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]	[ "Previous", "analyses", "of", "immunoglobulin", "V", "region", "promoters", "has", "led", "to", "the", "discovery", "of", "a", "common", "octamer", "motif", "which", "is", "functionally", "important", "in", "the", "tissue-specific", "and", "developmentally", "regulated", "transcriptional", "activation", "of", "immunoglobulin", "genes", "." ]
[ 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 3, 4, 0, 0, 0 ]	[ "The", "germline", "promoters", "(", "Ko", ")", "located", "upstream", "of", "the", "J", "region", "gene", "segments", "of", "the", "kappa", "locus", "also", "contain", "an", "octamer", "motif", "(", "containing", "a", "single", "base", "pair", "mutation", "and", "referred", "to", "as", "the", "variant", "octamer", ")", "which", "has", "been", "shown", "previously", "to", "bind", "Oct-1", "and", "Oct-2", "transcription", "factors", "in", "vitro", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0 ]	[ "To", "further", "elucidate", "the", "role", "of", "this", "variant", "octamer", "motif", "in", "the", "regulation", "of", "germline", "transcription", "from", "the", "unrearranged", "kappa", "locus", ",", "we", "have", "quantitated", "the", "relative", "binding", "affinity", "of", "Oct-1", "and", "Oct-2", "for", "the", "variant", "octamer", "motif", "and", "determined", "the", "functional", "role", "of", "this", "octamer", "motif", "in", "transcriptional", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]	[ "We", "find", "that", ",", "although", "the", "variant", "octamer", "motif", "binds", "Oct-1", "and", "Oct-2", "in", "vitro", "with", "5-fold", "lower", "affinity", "than", "the", "consensus", "octamer", "motif", ",", "mutation", "of", "the", "variant", "octamer", "motif", "to", "either", "a", "consensus", "octamer", "or", "non-octamer", "motif", "has", "no", "effect", "on", "transcriptional", "activation", "from", "the", "germline", "promoter", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 0, 1, 2, 0 ]	[ "We", "also", "find", "significant", "differences", "in", "activation", "of", "germline", "and", "V", "region", "promoters", "by", "kappa", "enhancers", "." ]
[ 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Our", "results", "suggest", "that", "the", "germline", "promoters", "and", "V", "region", "promoters", "differ", "in", "their", "dependence", "on", "octamer", "for", "activation", "and", "respond", "differently", "to", "enhancer", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]	[ "These", "findings", "have", "important", "implications", "in", "regulation", "of", "germline", "transcription", "as", "well", "as", "concomitant", "activation", "of", "the", "V-J", "recombination", "of", "the", "kappa", "light", "chain", "locus", "." ]
[ 0, 0, 5, 6, 6, 0, 5, 6, 6, 6, 6, 6, 6, 0, 5, 6, 0 ]	[ "Generation", "of", "CD1+RelB+", "dendritic", "cells", "and", "tartrate-resistant", "acid", "phosphatase-positive", "osteoclast-like", "multinucleated", "giant", "cells", "from", "human", "monocytes", "." ]
[ 0, 0, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 4, 4, 0, 3, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 5, 0 ]	[ "We", "previously", "showed", "that", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "and", "macrophage", "colony-stimulating", "factor", "(", "M-CSF", ")", "stimulate", "the", "differentiation", "of", "human", "monocytes", "into", "two", "phenotypically", "distinct", "types", "of", "macrophages", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0 ]	[ "However", ",", "in", "vivo", ",", "not", "only", "CSF", "but", "also", "many", "other", "cytokines", "are", "produced", "under", "various", "conditions", "." ]
[ 0, 3, 0, 0, 0, 0, 0, 5, 0, 3, 0 ]	[ "Those", "cytokines", "may", "modulate", "the", "differentiation", "of", "monocytes", "by", "CSFs", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 5, 6, 6, 0, 5, 0, 0, 0, 0, 0, 3, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 3, 0, 3, 0 ]	[ "In", "the", "present", "study", ",", "we", "showed", "that", "CD14+", "adherent", "human", "monocytes", "can", "differentiate", "into", "CD1+relB+", "dendritic", "cells", "(", "DC", ")", "by", "the", "combination", "of", "GM-CSF", "plus", "interleukin-4", "(", "IL-4", ")", "and", "that", "they", "differentiate", "into", "tartrate-resistant", "acid", "phosphatase", "(", "TRAP", ")", "-positive", "osteoclast-like", "multinucleated", "giant", "cells", "(", "MGC", ")", "by", "the", "combination", "of", "M-CSF", "plus", "IL-4", "." ]
[ 0, 0, 0, 7, 8, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 3, 0 ]	[ "However", ",", "the", "monocyte-derived", "DC", "were", "not", "terminally", "differentiated", "cells", ";", "they", "could", "still", "convert", "to", "macrophages", "in", "response", "to", "M-CSF", "." ]
[ 3, 4, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0 ]	[ "Tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "stimulated", "the", "terminal", "differentiation", "of", "the", "DC", "by", "downregulating", "the", "expression", "of", "the", "M-CSF", "receptor", ",", "cfms", "mRNA", ",", "and", "aborting", "the", "potential", "to", "convert", "to", "macrophages", "." ]
[ 0, 0, 0, 3, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0 ]	[ "In", "contrast", "to", "IL-4", ",", "interferon-gamma", "(", "IFN-gamma", ")", "had", "no", "demonstrable", "effect", "on", "the", "differentiation", "of", "monocytes", "." ]
[ 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 5, 0, 5, 0, 0, 0, 3, 0, 3, 0, 3, 0, 3, 0, 0, 0 ]	[ "Rather", ",", "IFN-gamma", "antagonized", "the", "effect", "of", "IL-4", "and", "suppressed", "the", "DC", "and", "MGC", "formation", "induced", "by", "GM-CSF", "+", "IL-4", "and", "M-CSF", "+", "IL-4", ",", "respectively", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 5, 0, 5, 6, 0 ]	[ "Taken", "together", ",", "these", "results", "provide", "a", "new", "aspect", "to", "our", "knowledge", "of", "monocyte", "differentiation", "and", "provide", "evidence", "that", "human", "monocytes", "are", "flexible", "in", "their", "differentiation", "potential", "and", "are", "precursors", "not", "only", "of", "macrophages", "but", "also", "of", "CD1+relB+DC", "and", "TRAP-positive", "MGC", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Such", "a", "diverse", "pathway", "of", "monocyte", "differentiation", "may", "constitute", "one", "of", "the", "basic", "mechanisms", "of", "immune", "regulation", "." ]
[ 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 3, 0, 3, 0, 3, 0 ]	[ "The", "NF-kappa", "B", "inhibitor", ",", "tepoxalin", ",", "suppresses", "surface", "expression", "of", "the", "cell", "adhesion", "molecules", "CD62E", ",", "CD11b/CD18", "and", "CD106", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]	[ "Tepoxalin", ",", "a", "dual", "enzyme", "inhibitor", "of", "cyclooxygenase", "and", "5-lipoxygenase", "has", "been", "shown", "to", "inhibit", "T-cell", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]	[ "Its", "immunosuppressive", "property", "is", "distinct", "from", "cyclosporin", "because", "only", "tepoxalin", ",", "but", "not", "cyclosporin", ",", "suppresses", "NF-kappa", "B", "activation", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 3, 4, 4, 4, 4, 4, 0, 3, 0, 0, 0, 0, 5, 6, 0, 3, 0, 5, 6, 6, 6, 6, 0 ]	[ "Here", "we", "report", "that", "tepoxalin", "selectively", "inhibits", "intercellular", "adhesion", "molecule-1", "(", "ICAM-1", ",", "CD54", ")", "/MAC-1", "(", "CD11b/CD18", ")", "dependent", "adhesion", "of", "polymorphonuclear", "cells", "to", "IL-1", "activated", "human", "umbilical", "vein", "endothelial", "cells", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]	[ "The", "mechanism", "of", "inhibition", "is", "related", "to", "the", "surface", "expression", "of", "several", "cell", "adhesion", "molecules", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 7, 8, 8, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 4, 4, 0, 3, 0, 0, 5, 6, 6, 6, 6, 0 ]	[ "Flow", "cytometry", "analyses", "on", "cultured", "cells", "that", "were", "treated", "with", "tepoxalin", "or", "antisense", "oligonucleotides", "to", "the", "P65/p50", "subunit", "of", "NF-kappa", "B", ",", "and", "then", "stimulated", "with", "PMA", ",", "revealed", "a", "reduced", "expression", "of", "CD11b/CD18", "on", "monocytic", "HL60", "cells", ",", "and", "endothelial", "adhesion", "molecule-1", "(", "CD62E", ")", "and", "vascular", "adhesion", "molecule-1", "(", "CD106", ")", "on", "human", "umbilical", "vein", "endothelial", "cells", "." ]
[ 0, 0, 0, 3, 4, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 0, 0, 0 ]	[ "Expression", "of", "other", "adhesion", "molecules", "such", "as", "lymphocyte", "function", "associated-antigen-1", "(", "CD11a/CD18", ")", "and", "CD54", "were", "unaffected", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 3, 0, 0, 0, 0, 0, 3, 0, 0 ]	[ "Tepoxalin", "also", "inhibited", "the", "secretion", "of", "a", "NF-kappa", "B", "regulated", "chemokine", ",", "IL-8", ",", "a", "known", "inducer", "of", "CD11b/CD18", "expression", "." ]

[ 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Ara-C", "activated", "JNKs", "only", "after", "prolonged", "incubation", "(", "90-120", "minutes", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 7, 8, 0 ]

[ "Thus", ",", "ceramide", "is", "not", "a", "positive", "signal", "for", "ERK", "activation", "in", "T-cell", "lines", "." ]

[ 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "effects", "of", "Ara-C", "on", "JNK", "activity", "may", "be", "mediated", "through", "secondary", "response", "pathways", "." ]

[ 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0 ]

[ "Comparative", "analysis", "identifies", "conserved", "tumor", "necrosis", "factor", "receptor-associated", "factor", "3", "binding", "sites", "in", "the", "human", "and", "simian", "Epstein-Barr", "virus", "oncogene", "LMP1", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Nonhuman", "primates", "are", "naturally", "infected", "with", "a", "B-lymphotropic", "herpesvirus", "closely", "related", "to", "Epstein-Barr", "virus", "(", "EBV", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "simian", "EBV", "share", "considerable", "genetic", ",", "biologic", ",", "and", "epidemiologic", "features", "with", "human", "EBV", ",", "including", "virus-induced", "tumorigenesis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "latent", ",", "transformation-associated", "viral", "genes", "demonstrate", "marked", "sequence", "divergence", "among", "species", "despite", "the", "conserved", "functions", "." ]

[ 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "have", "cloned", "the", "latent", "membrane", "protein", "1", "(", "LMP1", ")", "homologs", "from", "the", "simian", "EBV", "naturally", "infecting", "baboons", "(", "cercopithicine", "herpesvirus", "12", ",", "herpesvirus", "papio", ")", "and", "rhesus", "monkeys", "(", "cercopithicine", "herpesvirus", "15", ")", "for", "a", "comparative", "study", "with", "the", "human", "EBV", "oncogene", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 5, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 0, 0 ]

[ "The", "transmembrane", "domains", "are", "well", "conserved", ",", "but", "there", "is", "striking", "sequence", "divergence", "of", "the", "carboxy-terminal", "cytoplasmic", "domain", "essential", "for", "B-cell", "immortalization", "and", "interaction", "with", "the", "tumor", "necrosis", "factor", "receptor", "signaling", "pathway", "." ]

[ 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 0, 5, 6, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 1, 0, 0, 5, 6, 6, 0 ]

[ "Nevertheless", ",", "the", "simian", "EBV", "LMP1s", "retain", "most", "functions", "in", "common", "with", "EBV", "LMP1", ",", "including", "the", "ability", "to", "induce", "NF-", "(", "kappa", ")", "B", "activity", "in", "human", "cells", ",", "to", "bind", "the", "tumor", "necrosis", "factor-associated", "factor", "3", "(", "TRAF3", ")", "in", "vitro", ",", "and", "to", "induce", "expression", "of", "tumor", "necrosis", "factor-responsive", "genes", ",", "such", "as", "ICAM1", ",", "in", "human", "B", "lymphocytes", "." ]

[ 0, 1, 2, 2, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0 ]

[ "Multiple", "TRAF3", "binding", "sites", "containing", "a", "PXQXT/S", "core", "sequence", "can", "be", "identified", "in", "the", "simian", "EBV", "LMP1s", "by", "an", "in", "vitro", "binding", "assay", "." ]

[ 0, 1, 2, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 3, 0, 0, 0 ]

[ "A", "PXQXT/S-containing", "sequence", "is", "also", "present", "in", "the", "cytoplasmic", "domain", "of", "the", "Hodgkin", "'s", "disease", "marker", ",", "CD30", ",", "and", "binds", "TRAF3", "in", "vitro", "." ]

[ 0, 3, 4, 4, 4, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]

[ "The", "last", "13", "amino", "acids", "containing", "a", "PXQXT/S", "sequence", "are", "highly", "conserved", "in", "human", "and", "simian", "EBV", "LMP1", "but", "do", "not", "bind", "TRAF3", ",", "suggesting", "a", "distinct", "role", "for", "this", "conserved", "region", "of", "LMP1", "." ]

[ 0, 0, 1, 2, 2, 0, 3, 0, 0, 3, 4, 4, 4, 4, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "conserved", "TRAF3", "binding", "sites", "in", "LMP1", "and", "the", "CD30", "Hodgkin", "'s", "disease", "marker", "provides", "further", "evidence", "that", "a", "TRAF3", "-mediated", "signal", "transduction", "pathway", "may", "be", "important", "in", "malignant", "transformation", "." ]

[ 1, 2, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0 ]

[ "Chromosome", "1", "aneusomy", "with", "1p36", "under-representation", "is", "related", "to", "histologic", "grade", ",", "DNA", "aneuploidy", ",", "high", "c-erb", "B-2", "and", "loss", "of", "bcl-2", "expression", "in", "ductal", "breast", "carcinoma", "." ]

[ 1, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0 ]

[ "Chromosome", "1", "abnormalities", "with", "loss", "of", "1p36", "have", "been", "investigated", "in", "95", "breast-cancer", "samples", "by", "means", "of", "a", "dual-target", "fluorescence", "in-situ", "hybridization", "(", "FISH", ")", "technique", "using", "the", "pUC", "1.77", "and", "p1-79", "probes", ",", "specific", "for", "the", "1q12", "and", "1p36", "regions", ",", "respectively", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Abnormalities", "for", "one", "or", "both", "probes", "were", "detected", "in", "83/95", "samples", "." ]

[ 0, 1, 0, 0, 0, 0, 0, 0 ]

[ "Relative", "1p36", "under-representation", "was", "found", "in", "79/95", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "clinical", "relevance", "of", "these", "alterations", "was", "studied", "by", "comparing", "the", "FISH", "results", "with", "several", "parameters", "currently", "used", "in", "breast-cancer", "pathology", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Distinct", "patterns", "of", "chromosome", "1", "abnormalities", "were", "found", "among", "the", "histologic", "types", "of", "breast", "carcinoma", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0 ]

[ "Lobular", "or", "mucinous", "samples", "showed", "few", "or", "no", "alterations", ",", "whereas", "most", "ductal", "samples", "had", "high", "chromosome", "1", "polysomy", "with", "under-representation", "of", "1p36", "." ]

[ 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]

[ "In", "ductal", "carcinomas", ",", "chromosome", "1", "alterations", "increased", "with", "histologic", "grade", ",", "DNA", "aneuploidy", ",", "loss", "of", "bcl-2", "and", "high", "c-erb", "B-2", "expression", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "associations", "were", "found", "to", "be", "statistically", "significant", "." ]

[ 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0 ]

[ "No", "correlation", "between", "chromosome", "1", "alterations", "and", "nuclear", "grade", ",", "age", ",", "size", ",", "lymph-node", "involvement", ",", "hormonal", "receptor", "presence", ",", "proliferation", "activity", "or", "p53", "protein", "expression", "was", "detected", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "results", "indicate", "the", "utility", "of", "this", "FISH", "technique", "for", "a", "better", "definition", "of", "the", "biological", "characteristics", "of", "ductal", "carcinomas", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 0, 0, 5, 6, 0 ]

[ "G", "(", "Anh", ")", "MTetra", ",", "a", "natural", "bacterial", "cell", "wall", "breakdown", "product", ",", "induces", "interleukin-1", "beta", "and", "interleukin-6", "expression", "in", "human", "monocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "study", "of", "the", "molecular", "mechanisms", "involved", "in", "inflammatory", "cytokine", "expression", "[", "published", "erratum", "appears", "in", "J", "Biol", "Chem", "1994", "Jun", "17", ";", "269", "(", "24", ")", ":", "16983", "]" ]

[ 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "is", "believed", "that", "induction", "of", "cytokine", "expression", "by", "bacterial", "cell", "wall", "components", "plays", "a", "role", "in", "the", "development", "and", "course", "of", "sepsis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "most", "attention", "has", "been", "focused", "on", "lipopolysaccharide", "(", "LPS", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 3, 0, 0, 5, 6, 0 ]

[ "We", "studied", "the", "ability", "of", "N-acetylglucosaminyl-1", ",", "6-anhydro-N-acetylmuramyl-L-alanyl-D-", "isoglutamyl-m-diaminopimelyl-D-alanine", "(", "G", "(", "Anh", ")", "MTetra", ")", ",", "a", "naturally", "occurring", "breakdown", "product", "of", "peptidoglycan", "that", "is", "produced", "by", "soluble", "lytic", "transglycosylase", "of", "Escherichia", "coli", ",", "to", "induce", "cytokine", "expression", "in", "human", "monocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 4, 0, 9, 10, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0 ]

[ "G", "(", "Anh", ")", "MTetra", "was", "found", "to", "strongly", "induce", "interleukin", "(", "IL", ")", "-1", "beta", "and", "IL-6", "mRNA", "expression", "after", "2", "h", "and", "IL-1", "beta", "and", "IL-6", "protein", "secretion", "after", "48", "h", "of", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "increase", "in", "mRNA", "accumulation", "was", "at", "least", "partly", "due", "to", "an", "increase", "in", "the", "transcription", "rates", "of", "the", "respective", "genes", "and", "was", "accompanied", "by", "a", "strong", "induction", "of", "nuclear", "factor-kappa", "B", "and", "activator", "protein-1", "transcription", "factor", "expression", "." ]

[ 0, 0, 0, 0, 3, 4, 4, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Experiments", "using", "inhibitors", "of", "protein", "kinase", "C", ",", "protein", "kinase", "A", ",", "and", "tyrosine", "kinase-dependent", "pathways", "revealed", "that", "G", "(", "Anh", ")", "MTetra-induced", "IL-1", "beta", "and", "IL-6", "mRNA", "expression", "involves", "activation", "of", "an", "H7-inhibitable", "pathway", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]

[ "By", "using", "the", "protein", "synthesis", "inhibitor", "cycloheximide", ",", "it", "was", "shown", "that", "G", "(", "Anh", ")", "MTetra-induced", "IL-6", "mRNA", "expression", "depends", "on", "the", "synthesis", "of", "new", "protein", ",", "whereas", "G", "(", "Anh", ")", "MTetra-induced", "IL-1", "beta", "mRNA", "accumulation", "does", "not", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "When", "responses", "to", "G", "(", "Anh", ")", "MTetra", "were", "compared", "with", "those", "to", "LPS", "and", "muramyldipeptide", "(", "MDP", ")", ",", "it", "was", "found", "that", "the", "optimal", "response", "to", "G", "(", "Anh", ")", "MTetra", "induction", "was", "similar", "to", "that", "of", "LPS", "but", "significantly", "higher", "than", "the", "response", "to", "MDP", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "maximal", "G", "(", "Anh", ")", "MTetra-induced", "IL-1", "beta", "and", "IL-6", "mRNA", "expression", "could", "be", "enhanced", "by", "co-stimulation", "with", "LPS", "or", "MDP", ",", "suggesting", "that", "different", "receptors", "and/or", "transduction", "pathways", "were", "involved", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0 ]

[ "These", "results", "indicate", "that", "G", "(", "Anh", ")", "MTetra", "induces", "IL-1", "beta", "and", "IL-6", "expression", "in", "human", "monocytes", "suggesting", "a", "possible", "role", "for", "G", "(", "Anh", ")", "MTetra", "in", "the", "release", "of", "cytokines", "during", "sepsis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Increased", "proliferation", ",", "cytotoxicity", ",", "and", "gene", "expression", "after", "stimulation", "of", "human", "peripheral", "blood", "T", "lymphocytes", "through", "a", "surface", "ganglioside", "(", "GD3", ")", "[", "published", "erratum", "appears", "in", "J", "Immunol", "1994", "Jul", "15", ";", "153", "(", "2", ")", ":", "910", "]" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Previous", "studies", "have", "suggested", "that", "gangliosides", "have", "an", "important", "role", "in", "cell", "signaling", "and", "recognition", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "their", "specific", "function", "in", "these", "processes", "has", "not", "been", "clearly", "defined", "." ]

[ 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0 ]

[ "A", "mAb", ",", "R24", ",", "that", "reacts", "specifically", "with", "a", "cell", "surface", "ganglioside", "(", "GD3", ")", "has", "been", "demonstrated", "to", "stimulate", "proliferation", "of", "T", "cells", "derived", "from", "human", "peripheral", "blood", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0 ]

[ "In", "this", "study", ",", "we", "have", "investigated", "the", "mechanisms", "by", "which", "the", "R24", "mAb", "affects", "T", "cell", "functions", "." ]

[ 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 0, 3, 0, 3, 0, 0, 3, 0 ]

[ "We", "have", "observed", "that", "the", "R24", "mAb", "stimulates", "GD3+", "T", "cell", "proliferation", ",", "cytotoxicity", ",", "and", "surface", "marker", "expression", "of", "IL-2R", "alpha-chain", ",", "IL-2R", "beta-chain", ",", "HLA-DR", ",", "CD11a", ",", "and", "CD11c", "." ]

[ 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0 ]

[ "Additionally", ",", "IFN-gamma", "activity", "but", "not", "IL-1", ",", "IL-2", ",", "or", "IL-4", "activity", "was", "present", "in", "culture", "supernatants", "72", "h", "after", "R24", "stimulation", "." ]

[ 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 0, 0, 0, 3, 0, 0 ]

[ "In", "some", "donors", ",", "increased", "IL-6", "and", "TNF-alpha", "activity", "also", "was", "detected", "after", "R24", "treatment", "." ]

[ 0, 0, 3, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 3, 0, 3, 0 ]

[ "Furthermore", ",", "R24", "treatment", "resulted", "in", "translocation", "of", "c-rel", ",", "but", "little", "or", "no", "NF", "kappa", "B", "p50", "or", "p65", ",", "from", "the", "cytoplasm", "to", "the", "nucleus", "and", "an", "increase", "of", "NF", "kappa", "B", "binding", "complexes", "containing", "c-rel", "and", "p50", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "treatment", "also", "caused", "increased", "tyrosine", "phosphorylation", "of", "specific", "protein", "substrates", "." ]

[ 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 4, 4, 0, 0, 0, 0, 0, 3, 0, 0, 0 ]

[ "R24", "-stimulated", "increases", "in", "proliferation", ",", "cytotoxicity", ",", "and", "cell", "surface", "protein", "expression", "could", "be", "blocked", "by", "cyclosporin", "and", "staurosporin", ",", "indicating", "that", "cyclophilin/calcineurin", "and", "protein", "kinase", "C", "may", "be", "involved", "in", "the", "R24", "signaling", "pathway", "." ]

[ 0, 0, 0, 0, 0, 0, 3, 4, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]

[ "Additionally", ",", "herbimycin", "A", ",", "a", "tyrosine", "kinase", "inhibitor", ",", "blocked", "the", "R24", "-stimulated", "increase", "in", "proliferation", "but", "not", "cytotoxicity", "at", "concentrations", "consistent", "with", "specificity", "for", "tyrosine", "kinases", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 3, 0 ]

[ "These", "results", "suggest", "that", "multiple", "biochemical", "pathways", "are", "involved", "in", "the", "activation", "of", "human", "T", "cells", "by", "R24", "." ]

[ 0, 0, 3, 4, 4, 0, 3, 4, 4, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Genes", "encoding", "general", "initiation", "factors", "for", "RNA", "polymerase", "II", "transcription", "are", "dispersed", "in", "the", "human", "genome", "." ]

[ 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0 ]

[ "General", "transcription", "factors", "are", "required", "for", "accurate", "initiation", "of", "transcription", "by", "RNA", "polymerase", "II", "." ]

[ 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Human", "cDNAs", "encoding", "subunits", "of", "these", "factors", "have", "been", "cloned", "and", "sequenced", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 0, 3, 4, 0, 3, 4, 0, 3, 0, 3, 0, 0, 3, 4, 4, 0, 0, 3, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 0, 0 ]

[ "Using", "fluorescence", "in", "situ", "hybridization", "(", "FISH", ")", ",", "we", "show", "here", "that", "the", "genes", "encoding", "the", "TATA-box", "binding", "protein", "(", "TBP", ")", ",", "TFIIB", ",", "TFIIE", "alpha", ",", "TFIIE", "beta", ",", "RAP30", ",", "RAP74", "and", "the", "62", "kDa", "subunit", ",", "of", "TFIIH", "are", "located", "at", "the", "human", "chromosomal", "bands", "6q26-27", ",", "1p21-22", ",", "3q21-24", ",", "8p12", ",", "13q14", ",", "19p13.3", "and", "11p14-15.1", ",", "respectively", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "dispersed", "localization", "of", "a", "group", "of", "functionally", "related", "gene", "provides", "insights", "into", "the", "molecular", "mechanism", "of", "human", "genome", "evolution", "and", "their", "possible", "involvement", "in", "human", "diseases", "." ]

[ 3, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BCL-6", "and", "the", "molecular", "pathogenesis", "of", "B-cell", "lymphoma", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "results", "presented", "identify", "the", "first", "genetic", "lesion", "associated", "with", "DLCL", ",", "the", "most", "clinically", "relevant", "form", "of", "NHL", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]

[ "Although", "no", "proof", "yet", "exists", "of", "a", "role", "for", "these", "lesions", "in", "DLCL", "pathogenesis", ",", "the", "feature", "of", "the", "BCL-6", "gene", "product", ",", "its", "specific", "pattern", "of", "expression", "in", "B", "cells", ",", "and", "the", "clustering", "of", "lesions", "disrupting", "its", "regulatory", "domain", "strongly", "suggest", "that", "deregulation", "of", "BCL-6", "expression", "may", "contribute", "to", "DLCL", "development", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 1, 2, 0, 0, 3, 0, 0, 0, 0, 0, 0 ]

[ "A", "more", "precise", "definition", "of", "the", "role", "of", "BCL-6", "in", "normal", "and", "neoplastic", "B-cell", "development", "is", "the", "goal", "of", "ongoing", "study", "of", "transgenic", "mice", "engineered", "either", "to", "express", "BCL-6", "under", "heterologous", "promoters", "or", "lacking", "BCL-6", "function", "due", "to", "targeted", "deletions", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "addition", "to", "contributing", "to", "the", "understanding", "of", "DLCL", "pathogenesis", ",", "the", "identification", "of", "BCL-6", "lesions", "may", "have", "relevant", "clinical", "implications", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "DLCL", "represent", "a", "heterogeneous", "group", "of", "neoplasms", "which", "are", "treated", "homogeneously", "despite", "the", "fact", "that", "only", "50", "%", "of", "patients", "experience", "long-term", "disease-free", "survival", "(", "Schneider", "et", "al.", "1990", ")", "." ]

[ 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "fact", "that", "BCL-6", "rearrangements", "identify", "biologically", "and", "clinically", "distinct", "subsets", "of", "DLCL", "suggests", "that", "these", "lesions", "may", "be", "useful", "as", "markers", "in", "selection", "of", "differential", "therapeutic", "strategies", "based", "on", "different", "risk", "groups", "." ]

[ 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "the", "BCL-6", "rearrangements", "can", "be", "used", "to", "identify", "and", "monitor", "the", "malignant", "clone", "with", "sensitive", "PCR-based", "techniques", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Since", "clinical", "remission", "has", "been", "observed", "in", "a", "significant", "fraction", "of", "DLCL", "cases", ",", "these", "markers", "may", "serve", "as", "critical", "tools", "for", "sensitive", "monitoring", "of", "minimal", "residual", "disease", "and", "early", "diagnosis", "of", "relapse", "(", "Gribben", "et", "al.", "1993", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 5, 6, 6, 0 ]

[ "Pancreatic", "development", "and", "maturation", "of", "the", "islet", "B", "cell", "." ]

[ 0, 0, 7, 8, 8, 0 ]

[ "Studies", "of", "pluripotent", "islet", "cultures", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Pancreas", "organogenesis", "is", "a", "highly", "regulated", "process", ",", "in", "which", "two", "anlage", "evaginate", "from", "the", "primitive", "gut", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "They", "later", "fuse", ",", "and", ",", "under", "the", "influence", "of", "the", "surrounding", "mesenchyme", ",", "the", "mature", "organ", "develops", ",", "being", "mainly", "composed", "of", "ductal", ",", "exocrine", "and", "endocrine", "compartments", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Early", "buds", "are", "characterized", "by", "a", "branching", "morphogenesis", "of", "the", "ductal", "epithelium", "from", "which", "endocrine", "and", "exocrine", "precursor", "cells", "bud", "to", "eventually", "form", "the", "two", "other", "compartments", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "three", "compartments", "are", "thought", "to", "be", "of", "common", "endodermal", "origin", ";", "in", "contrast", "to", "earlier", "hypotheses", ",", "which", "suggested", "that", "the", "endocrine", "compartment", "was", "of", "neuroectodermal", "origin", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "is", "thus", "generally", "believed", "that", "the", "pancreatic", "endocrine-lineage", "possesses", "the", "ability", "to", "mature", "along", "a", "differentiation", "pathway", "that", "shares", "many", "characteristics", "with", "those", "of", "neuronal", "differentiation", "." ]

[ 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "During", "recent", "years", ",", "studies", "of", "insulin-gene", "regulation", "and", ",", "in", "particular", ",", "the", "tissue-specific", "transcriptional", "control", "of", "insulin-gene", "activity", "have", "provided", "information", "on", "pancreas", "development", "in", "general", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 0, 0 ]

[ "The", "present", "review", "summarizes", "these", "findings", ",", "with", "a", "special", "focus", "on", "our", "own", "studies", "on", "pluripotent", "endocrine", "cultures", "of", "rat", "pancreas", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "Octamer", "independent", "activation", "of", "transcription", "from", "the", "kappa", "immunoglobulin", "germline", "promoter", "." ]

[ 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "Previous", "analyses", "of", "immunoglobulin", "V", "region", "promoters", "has", "led", "to", "the", "discovery", "of", "a", "common", "octamer", "motif", "which", "is", "functionally", "important", "in", "the", "tissue-specific", "and", "developmentally", "regulated", "transcriptional", "activation", "of", "immunoglobulin", "genes", "." ]

[ 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 3, 4, 0, 0, 0 ]

[ "The", "germline", "promoters", "(", "Ko", ")", "located", "upstream", "of", "the", "J", "region", "gene", "segments", "of", "the", "kappa", "locus", "also", "contain", "an", "octamer", "motif", "(", "containing", "a", "single", "base", "pair", "mutation", "and", "referred", "to", "as", "the", "variant", "octamer", ")", "which", "has", "been", "shown", "previously", "to", "bind", "Oct-1", "and", "Oct-2", "transcription", "factors", "in", "vitro", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0 ]

[ "To", "further", "elucidate", "the", "role", "of", "this", "variant", "octamer", "motif", "in", "the", "regulation", "of", "germline", "transcription", "from", "the", "unrearranged", "kappa", "locus", ",", "we", "have", "quantitated", "the", "relative", "binding", "affinity", "of", "Oct-1", "and", "Oct-2", "for", "the", "variant", "octamer", "motif", "and", "determined", "the", "functional", "role", "of", "this", "octamer", "motif", "in", "transcriptional", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "We", "find", "that", ",", "although", "the", "variant", "octamer", "motif", "binds", "Oct-1", "and", "Oct-2", "in", "vitro", "with", "5-fold", "lower", "affinity", "than", "the", "consensus", "octamer", "motif", ",", "mutation", "of", "the", "variant", "octamer", "motif", "to", "either", "a", "consensus", "octamer", "or", "non-octamer", "motif", "has", "no", "effect", "on", "transcriptional", "activation", "from", "the", "germline", "promoter", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 0, 1, 2, 0 ]

[ "We", "also", "find", "significant", "differences", "in", "activation", "of", "germline", "and", "V", "region", "promoters", "by", "kappa", "enhancers", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Our", "results", "suggest", "that", "the", "germline", "promoters", "and", "V", "region", "promoters", "differ", "in", "their", "dependence", "on", "octamer", "for", "activation", "and", "respond", "differently", "to", "enhancer", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0 ]

[ "These", "findings", "have", "important", "implications", "in", "regulation", "of", "germline", "transcription", "as", "well", "as", "concomitant", "activation", "of", "the", "V-J", "recombination", "of", "the", "kappa", "light", "chain", "locus", "." ]

[ 0, 0, 5, 6, 6, 0, 5, 6, 6, 6, 6, 6, 6, 0, 5, 6, 0 ]

[ "Generation", "of", "CD1+RelB+", "dendritic", "cells", "and", "tartrate-resistant", "acid", "phosphatase-positive", "osteoclast-like", "multinucleated", "giant", "cells", "from", "human", "monocytes", "." ]

[ 0, 0, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 4, 4, 0, 3, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 5, 0 ]

[ "We", "previously", "showed", "that", "granulocyte-macrophage", "colony-stimulating", "factor", "(", "GM-CSF", ")", "and", "macrophage", "colony-stimulating", "factor", "(", "M-CSF", ")", "stimulate", "the", "differentiation", "of", "human", "monocytes", "into", "two", "phenotypically", "distinct", "types", "of", "macrophages", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "in", "vivo", ",", "not", "only", "CSF", "but", "also", "many", "other", "cytokines", "are", "produced", "under", "various", "conditions", "." ]

[ 0, 3, 0, 0, 0, 0, 0, 5, 0, 3, 0 ]

[ "Those", "cytokines", "may", "modulate", "the", "differentiation", "of", "monocytes", "by", "CSFs", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 0, 0, 0, 5, 6, 6, 0, 5, 0, 0, 0, 0, 0, 3, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 5, 6, 6, 6, 6, 6, 6, 6, 6, 6, 6, 0, 5, 0, 0, 0, 0, 0, 3, 0, 3, 0 ]

[ "In", "the", "present", "study", ",", "we", "showed", "that", "CD14+", "adherent", "human", "monocytes", "can", "differentiate", "into", "CD1+relB+", "dendritic", "cells", "(", "DC", ")", "by", "the", "combination", "of", "GM-CSF", "plus", "interleukin-4", "(", "IL-4", ")", "and", "that", "they", "differentiate", "into", "tartrate-resistant", "acid", "phosphatase", "(", "TRAP", ")", "-positive", "osteoclast-like", "multinucleated", "giant", "cells", "(", "MGC", ")", "by", "the", "combination", "of", "M-CSF", "plus", "IL-4", "." ]

[ 0, 0, 0, 7, 8, 0, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 3, 0 ]

[ "However", ",", "the", "monocyte-derived", "DC", "were", "not", "terminally", "differentiated", "cells", ";", "they", "could", "still", "convert", "to", "macrophages", "in", "response", "to", "M-CSF", "." ]

[ 3, 4, 4, 0, 3, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 3, 4, 0, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0 ]

[ "Tumor", "necrosis", "factor-alpha", "(", "TNF-alpha", ")", "stimulated", "the", "terminal", "differentiation", "of", "the", "DC", "by", "downregulating", "the", "expression", "of", "the", "M-CSF", "receptor", ",", "cfms", "mRNA", ",", "and", "aborting", "the", "potential", "to", "convert", "to", "macrophages", "." ]

[ 0, 0, 0, 3, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0 ]

[ "In", "contrast", "to", "IL-4", ",", "interferon-gamma", "(", "IFN-gamma", ")", "had", "no", "demonstrable", "effect", "on", "the", "differentiation", "of", "monocytes", "." ]

[ 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 5, 0, 5, 0, 0, 0, 3, 0, 3, 0, 3, 0, 3, 0, 0, 0 ]

[ "Rather", ",", "IFN-gamma", "antagonized", "the", "effect", "of", "IL-4", "and", "suppressed", "the", "DC", "and", "MGC", "formation", "induced", "by", "GM-CSF", "+", "IL-4", "and", "M-CSF", "+", "IL-4", ",", "respectively", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 5, 0, 5, 6, 0 ]

[ "Taken", "together", ",", "these", "results", "provide", "a", "new", "aspect", "to", "our", "knowledge", "of", "monocyte", "differentiation", "and", "provide", "evidence", "that", "human", "monocytes", "are", "flexible", "in", "their", "differentiation", "potential", "and", "are", "precursors", "not", "only", "of", "macrophages", "but", "also", "of", "CD1+relB+DC", "and", "TRAP-positive", "MGC", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Such", "a", "diverse", "pathway", "of", "monocyte", "differentiation", "may", "constitute", "one", "of", "the", "basic", "mechanisms", "of", "immune", "regulation", "." ]

[ 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 3, 0, 3, 0, 3, 0 ]

[ "The", "NF-kappa", "B", "inhibitor", ",", "tepoxalin", ",", "suppresses", "surface", "expression", "of", "the", "cell", "adhesion", "molecules", "CD62E", ",", "CD11b/CD18", "and", "CD106", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Tepoxalin", ",", "a", "dual", "enzyme", "inhibitor", "of", "cyclooxygenase", "and", "5-lipoxygenase", "has", "been", "shown", "to", "inhibit", "T-cell", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 0 ]

[ "Its", "immunosuppressive", "property", "is", "distinct", "from", "cyclosporin", "because", "only", "tepoxalin", ",", "but", "not", "cyclosporin", ",", "suppresses", "NF-kappa", "B", "activation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 3, 4, 4, 4, 4, 4, 0, 3, 0, 0, 0, 0, 5, 6, 0, 3, 0, 5, 6, 6, 6, 6, 0 ]

[ "Here", "we", "report", "that", "tepoxalin", "selectively", "inhibits", "intercellular", "adhesion", "molecule-1", "(", "ICAM-1", ",", "CD54", ")", "/MAC-1", "(", "CD11b/CD18", ")", "dependent", "adhesion", "of", "polymorphonuclear", "cells", "to", "IL-1", "activated", "human", "umbilical", "vein", "endothelial", "cells", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0 ]

[ "The", "mechanism", "of", "inhibition", "is", "related", "to", "the", "surface", "expression", "of", "several", "cell", "adhesion", "molecules", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 0, 3, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 7, 8, 8, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 4, 4, 0, 3, 0, 0, 5, 6, 6, 6, 6, 0 ]

[ "Flow", "cytometry", "analyses", "on", "cultured", "cells", "that", "were", "treated", "with", "tepoxalin", "or", "antisense", "oligonucleotides", "to", "the", "P65/p50", "subunit", "of", "NF-kappa", "B", ",", "and", "then", "stimulated", "with", "PMA", ",", "revealed", "a", "reduced", "expression", "of", "CD11b/CD18", "on", "monocytic", "HL60", "cells", ",", "and", "endothelial", "adhesion", "molecule-1", "(", "CD62E", ")", "and", "vascular", "adhesion", "molecule-1", "(", "CD106", ")", "on", "human", "umbilical", "vein", "endothelial", "cells", "." ]

[ 0, 0, 0, 3, 4, 0, 0, 3, 4, 4, 0, 3, 0, 0, 3, 0, 0, 0 ]

[ "Expression", "of", "other", "adhesion", "molecules", "such", "as", "lymphocyte", "function", "associated-antigen-1", "(", "CD11a/CD18", ")", "and", "CD54", "were", "unaffected", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 0, 3, 0, 0, 0, 0, 0, 3, 0, 0 ]

[ "Tepoxalin", "also", "inhibited", "the", "secretion", "of", "a", "NF-kappa", "B", "regulated", "chemokine", ",", "IL-8", ",", "a", "known", "inducer", "of", "CD11b/CD18", "expression", "." ]