tags
sequencelengths 2
166
| tokens
sequencelengths 2
166
|
---|---|
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Retinoic",
"acid",
"(",
"RA",
")",
",",
"a",
"vitamin",
"A",
"derivative",
",",
"exerts",
"a",
"wide",
"range",
"of",
"biological",
"effects",
"related",
"to",
"cell",
"proliferation",
"and",
"differentiation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
0,
0
] | [
"The",
"pleiotropic",
"effects",
"of",
"RA",
"are",
"thought",
"to",
"be",
"mediated",
"through",
"specific",
"nuclear",
"RA",
"receptors",
"(",
"RARs",
")",
"."
] |
[
3,
0,
0,
0,
0,
3,
4,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
4,
4,
0
] | [
"RARs",
"are",
"members",
"of",
"the",
"steroid/thyroid",
"hormone",
"receptor",
"superfamily",
"and",
"exhibit",
"a",
"molecular",
"structure",
"that",
"possess",
"discrete",
"DNA-binding",
"and",
"RA",
"(",
"ligand",
")",
"-binding",
"domains",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] | [
"In",
"hematopoietic",
"system",
",",
"RA",
"and",
"RARs",
",",
"predominantly",
"RAR",
"alpha",
"may",
"play",
"key",
"roles",
"for",
"the",
"proliferation",
"and",
"differentiation",
"of",
"hematopoietic",
"progenitors",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"However",
",",
"it",
"is",
"currently",
"unknown",
"how",
"RA",
"and",
"RARs",
"are",
"involved",
"in",
"regulating",
"normal",
"hematopoietic",
"differentiation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
3,
4,
0,
0,
5,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
1,
2,
2,
2,
0,
0,
0,
0,
7,
8,
8,
0,
7,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] | [
"To",
"make",
"clear",
"the",
"roles",
"of",
"RA",
"and",
"RAR",
"alpha",
"in",
"the",
"normal",
"hematopoiesis",
",",
"I",
"have",
"introduced",
"the",
"construct",
"of",
"human",
"RAR",
"alpha",
"(",
"hRAR",
"alpha",
")",
"into",
"murine",
"bone",
"marrow",
"cells",
"with",
"retroviral",
"vector",
",",
"and",
"selected",
"infected",
"cells",
"with",
"drug",
"resistant",
"marker",
"(",
"Neo",
"(",
"r",
")",
")",
"cultured",
"on",
"the",
"stroma",
"cell",
"line",
"(",
"PA6-neo",
")",
",",
"and",
"analyzed",
"the",
"behavior",
"of",
"infected",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0
] | [
"All",
"of",
"procedure",
"were",
"done",
"in",
"vitro",
"."
] |
[
0,
0,
0,
0,
3,
4,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Most",
"cells",
"infected",
"with",
"hRAR",
"alpha",
"exhibited",
"promyelocytic",
"morphology",
"and",
"were",
"thought",
"to",
"be",
"blocked",
"at",
"the",
"promyelocytic",
"stage",
"in",
"their",
"myeloid",
"differentiation",
"."
] |
[
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Furthermore",
",",
"these",
"immature",
"cells",
"differentiated",
"terminally",
"into",
"mature",
"granulocytes",
"by",
"adding",
"with",
"RA",
"(",
"10",
"(",
"-6",
")",
"M",
")",
"."
] |
[
3,
4,
5,
6,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0
] | [
"RAR",
"alpha",
"infected",
"cells",
"were",
"also",
"able",
"to",
"differentiate",
"into",
"mature",
"macrophages",
"in",
"the",
"both",
"of",
"long",
"term",
"culture",
"and",
"IL3",
"colony",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
5,
6,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"These",
"observations",
"suggest",
"that",
"an",
"overexpression",
"of",
"RAR",
"alpha",
"alone",
"is",
"effective",
"to",
"suppress",
"myeloid",
"cell",
"differentiation",
"and",
"RAR",
"alpha",
"plays",
"a",
"crucial",
"role",
"in",
"the",
"terminal",
"differentiation",
"of",
"myeloid",
"precursors",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
5,
6,
6,
6,
0
] | [
"The",
"system",
"described",
"here",
"may",
"serve",
"as",
"a",
"model",
"for",
"studying",
"the",
"the",
"essential",
"genes",
"for",
"differentiation",
"of",
"normal",
"bone",
"marrow",
"cells",
"."
] |
[
0,
0,
0,
1,
2,
0,
0,
5,
6,
6,
0
] | [
"Hypoxic",
"induction",
"of",
"interleukin-8",
"gene",
"expression",
"in",
"human",
"endothelial",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0
] | [
"Because",
"leukocyte-mediated",
"tissue",
"damage",
"is",
"an",
"important",
"component",
"of",
"the",
"pathologic",
"picture",
"in",
"ischemia/reperfusion",
",",
"we",
"have",
"sought",
"mechanisms",
"by",
"which",
"PMNs",
"are",
"directed",
"into",
"hypoxic",
"tissue",
"."
] |
[
0,
0,
5,
6,
6,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
3,
0
] | [
"Incubation",
"of",
"human",
"endothelial",
"cells",
"(",
"ECs",
")",
"in",
"hypoxia",
",",
"PO2",
"approximately",
"14-18",
"Torr",
",",
"led",
"to",
"time-dependent",
"release",
"of",
"IL-8",
"antigen",
"into",
"the",
"conditioned",
"medium",
";",
"this",
"was",
"accompanied",
"by",
"increased",
"chemotactic",
"activity",
"for",
"PMNs",
",",
"blocked",
"by",
"antibody",
"to",
"IL-8",
"."
] |
[
0,
0,
3,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
9,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Production",
"of",
"IL-8",
"by",
"hypoxic",
"ECs",
"occurred",
"concomitantly",
"with",
"both",
"increased",
"levels",
"of",
"IL-8",
"mRNA",
",",
"based",
"on",
"polymerase",
"chain",
"reaction",
"analysis",
",",
"and",
"increased",
"IL-8",
"transcription",
",",
"based",
"on",
"nuclear",
"run-on",
"assays",
"."
] |
[
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
9,
0,
3,
4,
4,
0,
0,
0,
0,
0,
3,
4,
0,
3,
4,
0
] | [
"Northern",
"analysis",
"of",
"mRNA",
"from",
"hypoxic",
"ECs",
"also",
"demonstrated",
"increased",
"levels",
"of",
"mRNA",
"for",
"macrophage",
"chemotactic",
"protein-1",
",",
"another",
"member",
"of",
"the",
"chemokine",
"superfamily",
"of",
"proinflammatory",
"cytokines",
"."
] |
[
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0
] | [
"IL-8",
"gene",
"induction",
"was",
"associated",
"with",
"the",
"presence",
"of",
"increased",
"binding",
"activity",
"in",
"nuclear",
"extracts",
"from",
"hypoxic",
"ECs",
"for",
"the",
"NF-kB",
"site",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0
] | [
"Studies",
"with",
"human",
"umbilical",
"vein",
"segments",
"exposed",
"to",
"hypoxia",
"also",
"demonstrated",
"increased",
"elaboration",
"of",
"IL-8",
"antigen",
"compared",
"with",
"normoxic",
"controls",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0
] | [
"In",
"mice",
"exposed",
"to",
"hypoxia",
"(",
"PO2",
"approximately",
"30-40",
"Torr",
")",
",",
"there",
"was",
"increased",
"pulmonary",
"leukostasis",
",",
"as",
"evidenced",
"by",
"increased",
"myeloperoxidase",
"activity",
"in",
"tissue",
"homogenates",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"In",
"parallel",
",",
"increased",
"levels",
"of",
"transcripts",
"for",
"IP-10",
",",
"a",
"murine",
"homologue",
"in",
"the",
"chemokine",
"family",
"related",
"to",
"IL-8",
",",
"were",
"observed",
"in",
"hypoxic",
"lung",
"tissue",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Taken",
"together",
",",
"these",
"data",
"suggest",
"that",
"hypoxia",
"constitutes",
"a",
"stimulus",
"for",
"leukocyte",
"chemotaxis",
"and",
"tissue",
"leukostasis",
"."
] |
[
3,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
0,
0,
0,
0,
0,
0
] | [
"Thrombin",
"and",
"thrombin",
"receptor",
"agonist",
"peptide",
"induce",
"early",
"events",
"of",
"T",
"cell",
"activation",
"and",
"synergize",
"with",
"TCR",
"cross-linking",
"for",
"CD69",
"expression",
"and",
"interleukin",
"2",
"production",
"."
] |
[
3,
0,
0,
0,
7,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Thrombin",
"stimulation",
"of",
"the",
"T",
"leukemic",
"cell",
"line",
"Jurkat",
"induced",
"a",
"transient",
"increase",
"in",
"[",
"Ca2+",
"]",
"i",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Proteolytic",
"activity",
"of",
"the",
"enzyme",
"was",
"required",
"for",
"this",
"effect",
"since",
"diisopropyl",
"fluorophosphate-thrombin",
"failed",
"to",
"increase",
"[",
"Ca2+",
"]",
"i",
"."
] |
[
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0
] | [
"Furthermore",
",",
"hirudin",
"and",
"anti-thrombin",
"III",
"inhibited",
"the",
"thrombin-induced",
"[",
"Ca2+",
"]",
"i",
"rise",
"in",
"Jurkat",
"T",
"cells",
"."
] |
[
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"A",
"synthetic",
"thrombin",
"receptor",
"agonist",
"peptide",
"(",
"TRP",
")",
"of",
"7",
"residues",
"(",
"SFLLRNP",
")",
"was",
"found",
"to",
"be",
"as",
"effective",
"as",
"thrombin",
"for",
"[",
"Ca2+",
"]",
"i",
"mobilization",
",",
"and",
"both",
"agonists",
"induced",
"Ca2+",
"release",
"exclusively",
"from",
"internal",
"stores",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
0
] | [
"Thrombin",
"stimulated",
"tyrosine",
"phosphorylation",
"of",
"several",
"proteins",
"of",
"molecular",
"mass",
"40",
",",
"42",
",",
"70",
",",
"120",
",",
"and",
"130",
"kDa",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"There",
"was",
"a",
"good",
"correlation",
"between",
"thrombin",
"-induced",
"tyrosine",
"phosphorylation",
"of",
"the",
"latter",
"three",
"proteins",
"and",
"Ca2+",
"mobilization",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Thrombin",
"and",
"TRP",
"also",
"caused",
"translocation",
"of",
"protein",
"kinase",
"C",
"from",
"the",
"cytosol",
"to",
"the",
"plasma",
"membrane",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
4,
4,
0
] | [
"As",
"a",
"likely",
"consequence",
"of",
"these",
"events",
",",
"thrombin",
"activated",
"the",
"nuclear",
"factor",
"NF-kB",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
0,
0,
7,
8,
8,
8,
0,
0,
0,
3,
0,
0,
0,
0,
0,
7,
0,
0,
7,
8,
8,
0,
0,
7,
8,
0,
7,
8,
0,
0,
0,
3,
0,
0,
0,
0
] | [
"Several",
"cell",
"lines",
"of",
"hematopoietic",
"origin",
"including",
"the",
"leukemic",
"T",
"cell",
"line",
"HPB.ALL",
"and",
"the",
"erythroleukemic",
"cell",
"line",
"K562",
"were",
"responsive",
"to",
"thrombin",
",",
"whereas",
"others",
"such",
"as",
"THP1",
",",
"a",
"myelomonocytic",
"cell",
"line",
",",
"and",
"BL2",
",",
"a",
"Burkitt",
"lymphoma",
"were",
"refractory",
"to",
"thrombin",
"or",
"TRP",
"stimulation",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] | [
"The",
"magnitude",
"of",
"the",
"thrombin",
"response",
"in",
"the",
"different",
"cell",
"types",
"paralleled",
"the",
"expression",
"of",
"the",
"thrombin",
"receptor",
"mRNA",
"."
] |
[
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"We",
"found",
"that",
"activation",
"of",
"Jurkat",
"T",
"cells",
"by",
"a",
"combination",
"of",
"phytohemagglutinin",
"and",
"phorbol",
"12-myristate",
"13-acetate",
"led",
"to",
"a",
"dramatic",
"inhibition",
"of",
"thrombin",
"receptor",
"mRNA",
"expression",
"and",
"to",
"a",
"concomitant",
"loss",
"of",
"the",
"thrombin",
"response",
"."
] |
[
0,
0,
0,
0,
0,
3,
0,
0,
0,
3,
0,
0,
3,
4,
0,
0,
0,
3,
4,
4,
0,
0,
0,
7,
8,
8,
0,
0,
0,
5,
0
] | [
"Finally",
",",
"we",
"demonstrate",
"that",
"thrombin",
"and",
"TRP",
"enhanced",
"CD69",
"expression",
"and",
"interleukin",
"2",
"production",
"induced",
"by",
"T",
"cell",
"receptor",
"cross-linking",
"in",
"both",
"Jurkat",
"T",
"cells",
"and",
"peripheral",
"blood",
"lymphocytes",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
5,
6,
0,
0
] | [
"These",
"findings",
"highlight",
"the",
"role",
"of",
"thrombin",
"as",
"a",
"potential",
"regulator",
"of",
"T",
"lymphocyte",
"activation",
"."
] |
[
0,
0,
0,
5,
6,
6,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0
] | [
"Stress",
"response",
"of",
"senescent",
"T",
"lymphocytes",
":",
"reduced",
"hsp70",
"is",
"independent",
"of",
"the",
"proliferative",
"block",
"."
] |
[
7,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Senescent",
"human",
"T",
"lymphocyte",
"cultures",
"are",
"unable",
"to",
"undergo",
"proliferation",
",",
"but",
"show",
"no",
"difference",
"from",
"early",
"passage",
"cells",
"in",
"cytotoxic",
"function",
"or",
"surface",
"antigenic",
"profile",
"."
] |
[
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0
] | [
"A",
"second",
"feature",
"of",
"senescent",
"T",
"cells",
"is",
"the",
"dramatic",
"reduction",
"in",
"hsp70",
"production",
"in",
"response",
"to",
"heat",
"shock",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] | [
"This",
"decline",
"is",
"associated",
"with",
"a",
"decrease",
"in",
"binding",
"of",
"nuclear",
"extracts",
"to",
"the",
"consensus",
"heat",
"shock",
"element",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Interestingly",
",",
"the",
"progressive",
"decline",
"in",
"the",
"heat",
"shock",
"response",
"of",
"cultured",
"T",
"cells",
"correlates",
"with",
"the",
"percent",
"proliferative",
"life",
"span",
"completed",
"rather",
"than",
"with",
"the",
"actual",
"proliferative",
"activity",
"at",
"the",
"time",
"of",
"heat",
"shock",
"."
] |
[
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"This",
"suggests",
"that",
"for",
"senescent",
"T",
"cells",
"the",
"reduced",
"ability",
"to",
"respond",
"to",
"heat",
"shock",
"by",
"producing",
"hsp70",
",",
"although",
"possibly",
"lying",
"at",
"the",
"level",
"of",
"transcriptional",
"control",
",",
"may",
"nevertheless",
"be",
"unrelated",
"to",
"the",
"reduced",
"DNA",
"synthesis",
"or",
"the",
"diminished",
"proliferative",
"activity",
"also",
"manifested",
"by",
"these",
"cells",
"."
] |
[
0,
0,
3,
4,
0,
0,
0,
0,
3,
4,
4,
0,
7,
8,
8,
8,
8,
0
] | [
"Involvement",
"of",
"phospholipase",
"D",
"in",
"the",
"activation",
"of",
"transcription",
"factor",
"AP-1",
"in",
"human",
"T",
"lymphoid",
"Jurkat",
"cells",
"."
] |
[
0,
0,
0,
0,
3,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"induction",
"of",
"the",
"AP-1",
"transcription",
"factor",
"has",
"been",
"ascribed",
"to",
"the",
"early",
"events",
"leading",
"to",
"T",
"lymphocyte",
"activation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
2,
0
] | [
"We",
"have",
"examined",
"the",
"possibility",
"that",
"stimulation",
"of",
"phospholipase",
"D",
"(",
"PLD",
")",
"may",
"regulate",
"activation",
"of",
"transcription",
"factor",
"AP-1",
"in",
"human",
"T",
"cells",
"by",
"transfecting",
"human",
"T",
"lymphocyte",
"Jurkat",
"cells",
"with",
"a",
"plasmid",
"containing",
"an",
"AP-1",
"enhancer",
"element",
"and",
"a",
"chloramphenicol",
"acetyltransferase",
"reporter",
"gene",
"."
] |
[
0,
0,
0,
0,
3,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
3,
4,
4,
0
] | [
"We",
"have",
"detected",
"activatable",
"PLD",
"in",
"Jurkat",
"cells",
",",
"and",
"we",
"have",
"found",
"that",
"addition",
"of",
"phosphatidic",
"acid",
"(",
"PA",
")",
",",
"the",
"physiologic",
"product",
"of",
"PLD",
"action",
"on",
"phospholipids",
",",
"is",
"rapidly",
"incorporated",
"into",
"Jurkat",
"cells",
"and",
"leads",
"to",
"activation",
"of",
"transcription",
"factor",
"AP-1",
"."
] |
[
0,
0,
7,
8,
0,
3,
4,
0,
0,
3,
0,
3,
4,
4,
0
] | [
"Treatment",
"of",
"Jurkat",
"cells",
"with",
"anti-CD3",
"mAb",
"activated",
"both",
"PLD",
"and",
"transcription",
"factor",
"AP-1",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
3,
0,
0,
0,
0,
3,
0,
0,
1,
2,
0,
0
] | [
"Wortmannin",
",",
"an",
"inhibitor",
"of",
"receptor-coupled",
"PLD",
"activation",
",",
"blocked",
"the",
"anti-CD3",
"-induced",
"increases",
"in",
"both",
"PLD",
"activity",
"and",
"AP-1",
"enhancer",
"activity",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
3,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0
] | [
"We",
"found",
"a",
"good",
"correlation",
"in",
"the",
"transfected",
"cells",
"between",
"PLD",
"activation",
"and",
"induction",
"of",
"AP-1",
"enhancer",
"activity",
"under",
"different",
"experimental",
"conditions",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
1,
2,
0,
0
] | [
"Furthermore",
",",
"ethanol",
",",
"an",
"inhibitor",
"of",
"the",
"PLD",
"pathway",
",",
"blocked",
"the",
"anti-CD3-stimulated",
"AP-1",
"enhancer",
"activity",
"."
] |
[
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"However",
",",
"this",
"anti-CD3",
"-mediated",
"response",
"was",
"not",
"inhibited",
"by",
"neomycin",
",",
"an",
"inhibitor",
"of",
"phosphoinositide",
"hydrolysis",
"."
] |
[
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
4,
4,
0,
3,
0,
0
] | [
"The",
"increases",
"in",
"AP-1",
"enhancer",
"activity",
"induced",
"by",
"PA",
"or",
"anti-CD3",
"mAb",
"were",
"efficiently",
"abrogated",
"by",
"the",
"presence",
"of",
"propranolol",
",",
"an",
"inhibitor",
"of",
"PA",
"phosphohydrolase",
"and",
"protein",
"kinase",
"C",
"(",
"PKC",
")",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
3,
0,
0
] | [
"Furthermore",
",",
"the",
"PA",
"-and",
"the",
"anti-CD3",
"-induced",
"increases",
"in",
"AP-1",
"enhancer",
"activity",
"were",
"blocked",
"by",
"the",
"presence",
"of",
"PKC",
"inhibitors",
"or",
"by",
"PKC",
"down-regulation",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
3,
4,
4,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"These",
"data",
"indicate",
"that",
"PLD",
"stimulation",
"can",
"activate",
"the",
"transcription",
"factor",
"AP-1",
"in",
"T",
"lymphocytes",
",",
"and",
"suggest",
"that",
"the",
"induction",
"of",
"AP-1",
"enhancer",
"factor",
"activity",
"by",
"PA",
"is",
"mediated",
"via",
"PKC",
"stimulation",
",",
"either",
"through",
"a",
"direct",
"activating",
"effect",
"of",
"PA",
"or",
"through",
"PA-derived",
"diacylglycerol",
"formation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0
] | [
"These",
"data",
"also",
"provide",
"evidence",
"for",
"a",
"role",
"of",
"PLD",
"-derived",
"lipids",
"in",
"the",
"induction",
"of",
"AP-1",
"enhancer",
"activity",
"resulting",
"from",
"stimulation",
"of",
"the",
"TCR/CD3",
"complex",
",",
"suggesting",
"that",
"increased",
"PLD",
"activity",
"can",
"play",
"an",
"important",
"role",
"in",
"T",
"lymphocyte",
"activation",
"."
] |
[
0,
0,
1,
0,
0,
3,
4,
4,
4,
4,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
3,
4,
4,
0
] | [
"Upregulation",
"of",
"bcl-2",
"by",
"the",
"Epstein-Barr",
"virus",
"latent",
"membrane",
"protein",
"LMP1",
":",
"a",
"B-cell-specific",
"response",
"that",
"is",
"delayed",
"relative",
"to",
"NF-kappa",
"B",
"activation",
"and",
"to",
"induction",
"of",
"cell",
"surface",
"markers",
"."
] |
[
0,
0,
0,
0,
3,
4,
4,
4,
4,
3,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"An",
"ability",
"of",
"the",
"Epstein-Barr",
"virus",
"latent",
"membrane",
"protein",
"LMP1",
"to",
"enhance",
"the",
"survival",
"of",
"infected",
"B",
"cells",
"through",
"upregulation",
"of",
"the",
"bcl-2",
"oncogene",
"was",
"first",
"suggested",
"by",
"experiments",
"involving",
"gene",
"transfection",
"and",
"the",
"selection",
"of",
"stable",
"LMP1+",
"clones",
"(",
"S.Henderson",
",",
"M.",
"Rowe",
",",
"C.Gregory",
",",
"F.Wang",
",",
"E.Kieff",
",",
"and",
"A.Rickinson",
",",
"Cell",
"65",
":",
"1107-1115",
",",
"1991",
")",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"However",
",",
"it",
"was",
"not",
"possible",
"to",
"ascertain",
"whether",
"Bcl-2",
"upregulation",
"was",
"a",
"specific",
"consequence",
"of",
"LMP1",
"expression",
"or",
"an",
"artifact",
"of",
"the",
"selection",
"procedure",
"whereby",
"rare",
"Bcl-2+",
"cells",
"already",
"present",
"in",
"the",
"starting",
"population",
"might",
"best",
"be",
"able",
"to",
"tolerate",
"the",
"potentially",
"toxic",
"effects",
"of",
"LMP1",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
3,
4,
0,
0,
0,
0,
3,
4,
4,
3,
0,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"We",
"therefore",
"reexamined",
"this",
"issue",
"by",
"using",
"two",
"different",
"experimental",
"approaches",
"that",
"allowed",
"LMP1",
"-induced",
"effects",
"to",
"be",
"monitored",
"immediately",
"following",
"expression",
"of",
"the",
"viral",
"protein",
"and",
"in",
"the",
"absence",
"of",
"selective",
"pressures",
";",
"activation",
"of",
"the",
"NF-kappa",
"B",
"transcription",
"factor",
"and",
"upregulation",
"of",
"the",
"cell",
"adhesion",
"molecule",
"ICAM-1",
"were",
"used",
"as",
"early",
"indices",
"of",
"LMP1",
"function",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
3,
0,
0,
0,
0
] | [
"In",
"the",
"first",
"approach",
",",
"stable",
"clones",
"of",
"two",
"B-cell",
"lines",
"carrying",
"an",
"LMP1",
"gene",
"under",
"the",
"control",
"of",
"an",
"inducible",
"metallothionein",
"promoter",
"were",
"induced",
"to",
"express",
"LMP1",
"in",
"all",
"cells",
"."
] |
[
0,
0,
3,
4,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"Activation",
"of",
"NK-kappa",
"B",
"and",
"upregulation",
"of",
"ICAM-1",
"occurred",
"within",
"24",
"h",
"and",
"were",
"followed",
"at",
"48",
"to",
"72",
"h",
"by",
"upregulation",
"of",
"Bcl-2",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"In",
"the",
"second",
"approach",
",",
"we",
"tested",
"the",
"generality",
"of",
"this",
"phenomenon",
"by",
"transiently",
"expressing",
"LMP1",
"from",
"a",
"strong",
"constitutively",
"active",
"promoter",
"in",
"a",
"range",
"of",
"different",
"cell",
"types",
"."
] |
[
0,
0,
7,
8,
0,
0,
3,
4,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
0
] | [
"All",
"six",
"B-cell",
"lines",
"tested",
"showed",
"NF-kappa",
"B",
"activation",
"in",
"response",
"to",
"LMP1",
"expression",
",",
"and",
"this",
"was",
"followed",
"in",
"five",
"of",
"six",
"lines",
"by",
"expression",
"of",
"ICAM-1",
"and",
"Bcl-2",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
3,
4,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"In",
"the",
"same",
"experiments",
",",
"all",
"three",
"non-",
"B-cell",
"lines",
"showed",
"NF-kappa",
"B",
"activation",
"and",
"ICAM-1",
"upregulation",
"but",
"never",
"any",
"effect",
"upon",
"Bcl-2",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"We",
"therefore",
"conclude",
"that",
"Bcl-2",
"upregulation",
"is",
"part",
"of",
"the",
"panoply",
"of",
"cellular",
"changes",
"induced",
"by",
"LMP1",
"but",
"that",
"the",
"effect",
"is",
"cell",
"type",
"specific",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0
] | [
"Our",
"data",
"also",
"suggest",
"that",
"whilst",
"NF-kappa",
"B",
"may",
"be",
"an",
"essential",
"component",
"of",
"LMP1",
"signal",
"transduction",
",",
"other",
"cell-specific",
"factors",
"may",
"be",
"required",
"to",
"effect",
"some",
"functions",
"of",
"the",
"viral",
"protein",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
3,
0,
0,
3,
0,
0,
7,
8,
8,
8,
8,
0
] | [
"Long-term",
"inositol",
"phosphate",
"release",
",",
"but",
"not",
"tyrosine",
"kinase",
"activity",
",",
"correlates",
"with",
"IL-2",
"secretion",
"and",
"NF-AT",
"induction",
"in",
"anti-CD3-activated",
"peripheral",
"human",
"T",
"lymphocytes",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0
] | [
"The",
"cascade",
"of",
"events",
"within",
"the",
"first",
"few",
"minutes",
"of",
"T",
"cell",
"stimulation",
"has",
"been",
"well",
"characterized",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0
] | [
"Although",
"many",
"second",
"messengers",
"have",
"been",
"shown",
"to",
"be",
"necessary",
"and",
"sufficient",
"for",
"T",
"cell",
"activation",
"in",
"a",
"number",
"of",
"model",
"systems",
",",
"the",
"rate-limiting",
"step",
"in",
"peripheral",
"T",
"cells",
"has",
"not",
"been",
"demonstrated",
"."
] |
[
0,
0,
0,
0,
0,
3,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0
] | [
"To",
"model",
"effective",
"versus",
"ineffective",
"CD3",
"-mediated",
"stimulation",
"in",
"peripheral",
"T",
"cells",
",",
"we",
"used",
"two",
"anti-CD3",
"mAbs",
"that",
"differ",
"in",
"their",
"ability",
"to",
"stimulate",
"purified",
"T",
"cells",
":",
"OKT3",
",",
"which",
"causes",
"early",
"second",
"messenger",
"generation",
"but",
"is",
"unable",
"to",
"activate",
"T",
"cells",
"without",
"a",
"second",
"signal",
",",
"and",
"64.1",
",",
"which",
"stimulates",
"T",
"cell",
"proliferation",
"on",
"its",
"own",
"."
] |
[
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0
] | [
"We",
"found",
"that",
"tyrosine",
"kinase",
"activity",
"was",
"similar",
"for",
"both",
"mAbs",
"over",
"a",
"period",
"of",
"hours",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
0
] | [
"However",
",",
"the",
"inositol",
"phosphate",
"response",
"was",
"stronger",
"for",
"64.1",
"than",
"for",
"OKT3",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
0,
0,
0,
0,
0,
3,
0,
0
] | [
"To",
"tie",
"these",
"events",
"to",
"gene",
"activation",
",",
"we",
"measured",
"NF-kappa",
"B",
"and",
"NF-AT",
"activity",
"in",
"the",
"nucleus",
"after",
"anti-CD3",
"stimulation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
3,
0,
3,
0,
3,
0,
0,
0,
3,
0,
3,
4,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0
] | [
"Both",
"stimuli",
"induced",
"the",
"appearance",
"of",
"the",
"NF-kappa",
"B",
"components",
"(",
"c-Rel",
",",
"p65",
"(",
"RelA",
")",
",",
"and",
"p50",
"(",
"NF-kappa",
"B1",
")",
")",
"and",
"NF-kappa",
"B",
"DNA",
"binding",
"activity",
"in",
"the",
"nucleus",
"."
] |
[
0,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] | [
"However",
",",
"only",
"64.1",
"induced",
"NF-AT",
"in",
"the",
"nucleus",
",",
"correlating",
"with",
"its",
"ability",
"to",
"activate",
"T",
"cells",
"."
] |
[
0,
0,
3,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0
] | [
"Thus",
",",
"NF-AT",
"induction",
"and",
"IL-2",
"secretion",
"were",
"correlated",
"with",
"the",
"levels",
"of",
"inositol",
"phosphate",
"release",
"but",
"not",
"with",
"gross",
"levels",
"of",
"tyrosine",
"kinase",
"activity",
"induced",
"late",
"following",
"the",
"response",
"."
] |
[
0,
0,
0,
0,
0,
3,
4,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"On",
"the",
"other",
"hand",
",",
"NF-kappa",
"B",
"induction",
"and",
"IL-2",
"receptor",
"expression",
"occurred",
"even",
"with",
"the",
"smaller",
"second",
"messenger",
"response",
"generated",
"by",
"OKT3",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"HLA-DR-",
",",
"CD33+",
",",
"CD56+",
",",
"CD16-",
"myeloid/natural",
"killer",
"cell",
"acute",
"leukemia",
":",
"a",
"previously",
"unrecognized",
"form",
"of",
"acute",
"leukemia",
"potentially",
"misdiagnosed",
"as",
"French-American-British",
"acute",
"myeloid",
"leukemia-M3",
"[",
"see",
"comments",
"]"
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
6,
6,
6,
0
] | [
"We",
"have",
"identified",
"and",
"characterized",
"a",
"previously",
"unrecognized",
"form",
"of",
"acute",
"leukemia",
"that",
"shares",
"features",
"of",
"both",
"myeloid",
"and",
"natural",
"killer",
"(",
"NK",
")",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
0,
0
] | [
"From",
"a",
"consecutive",
"series",
"of",
"350",
"cases",
"of",
"adult",
"de",
"novo",
"acute",
"myeloid",
"leukemia",
"(",
"AML",
")",
",",
"we",
"identified",
"20",
"cases",
"(",
"6",
"%",
")",
"with",
"a",
"unique",
"immunophenotype",
":",
"CD33+",
",",
"CD56+",
",",
"CD11a+",
",",
"CD13lo",
",",
"CD15lo",
",",
"CD34+/-",
",",
"HLA-DR",
"-",
",",
"CD16",
"-",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
4,
4,
4,
0,
0,
5,
6,
0
] | [
"Multicolor",
"flow",
"cytometric",
"assays",
"confirmed",
"the",
"coexpression",
"of",
"myeloid",
"(",
"CD33",
",",
"CD13",
",",
"CD15",
")",
"and",
"NK",
"cell-associated",
"(",
"CD56",
")",
"antigens",
"in",
"each",
"case",
",",
"whereas",
"reverse",
"transcription",
"polymerase",
"chain",
"reaction",
"(",
"RT-PCR",
")",
"assays",
"confirmed",
"the",
"identity",
"of",
"CD56",
"(",
"neural",
"cell",
"adhesion",
"molecule",
")",
"in",
"leukemic",
"blasts",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
3,
0,
3,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
4,
4,
4,
4,
4,
0,
0
] | [
"Although",
"two",
"cases",
"expressed",
"CD4",
",",
"no",
"case",
"expressed",
"CD2",
",",
"CD3",
",",
"or",
"CD8",
"and",
"no",
"case",
"showed",
"clonal",
"rearrangement",
"of",
"genes",
"encoding",
"the",
"T-cell",
"receptor",
"(",
"TCR",
"beta",
",",
"gamma",
",",
"delta",
")",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
4,
0,
0
] | [
"Leukemic",
"blasts",
"in",
"the",
"majority",
"of",
"cases",
"shared",
"unique",
"morphologic",
"features",
"(",
"deeply",
"invaginated",
"nuclear",
"membranes",
",",
"scant",
"cytoplasm",
"with",
"fine",
"azurophilic",
"granularity",
",",
"and",
"finely",
"granular",
"Sudan",
"black",
"B",
"and",
"myeloperoxidase",
"cytochemical",
"reactivity",
")",
"that",
"were",
"remarkably",
"similar",
"to",
"those",
"of",
"acute",
"promyelocytic",
"leukemia",
"(",
"APL",
")",
";",
"particularly",
"the",
"microgranular",
"variant",
"(",
"FAB",
"AML-M3v",
")",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
10,
10,
10,
10,
10,
10,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
2,
2,
2,
2,
0,
0,
9,
10,
10,
10,
10,
10,
10,
0
] | [
"However",
",",
"all",
"20",
"cases",
"lacked",
"the",
"t",
"(",
"15",
";",
"17",
")",
"and",
"17",
"cases",
"tested",
"lacked",
"the",
"promyelocytic/retinoic",
"acid",
"receptor",
"alpha",
"(",
"RAR",
"alpha",
")",
"fusion",
"transcript",
"in",
"RT-PCR",
"assays",
";",
"12",
"cases",
"had",
"46",
",",
"XX",
"or",
"46",
",",
"XY",
"karyotypes",
",",
"whereas",
"2",
"cases",
"had",
"abnormalities",
"of",
"chromosome",
"17q",
":",
"1",
"with",
"del",
"(",
"17",
")",
"(",
"q25",
")",
"and",
"the",
"other",
"with",
"t",
"(",
"11",
";",
"17",
")",
"(",
"q23",
";",
"q21",
")",
"and",
"the",
"promyelocytic",
"leukemia",
"zinc",
"finger/RAR",
"alpha",
"fusion",
"transcript",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"All",
"cases",
"tested",
"(",
"6/20",
")",
",",
"including",
"the",
"case",
"with",
"t",
"(",
"11",
";",
"17",
")",
",",
"failed",
"to",
"differentiate",
"in",
"vitro",
"in",
"response",
"to",
"all-trans",
"retinoic",
"acid",
"(",
"ATRA",
")",
",",
"suggesting",
"that",
"these",
"cases",
"may",
"account",
"for",
"some",
"APLs",
"that",
"have",
"not",
"shown",
"a",
"clinical",
"response",
"to",
"ATRA",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
5,
6,
6,
6,
6,
6,
6,
0
] | [
"Four",
"of",
"6",
"cases",
"tested",
"showed",
"functional",
"NK",
"cell-mediated",
"cytotoxicity",
",",
"suggesting",
"a",
"relationship",
"between",
"these",
"unique",
"CD33+",
",",
"CD56+",
",",
"CD16",
"-acute",
"leukemias",
"and",
"normal",
"CD56+",
",",
"CD16-",
"NK",
"precursor",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Using",
"a",
"combination",
"of",
"panning",
"and",
"multiparameter",
"flow",
"cytometric",
"sorting",
",",
"we",
"identified",
"a",
"normal",
"CD56+",
",",
"CD33+",
",",
"CD16-",
"counterpart",
"cell",
"at",
"a",
"frequency",
"of",
"1",
"%",
"to",
"2",
"%",
"in",
"the",
"peripheral",
"blood",
"of",
"healthy",
"individuals",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Our",
"studies",
"suggest",
"that",
"this",
"form",
"of",
"acute",
"leukemia",
"may",
"arise",
"from",
"transformation",
"of",
"a",
"precursor",
"cell",
"common",
"to",
"both",
"the",
"myeloid",
"and",
"NK",
"cell",
"lineages",
";",
"thus",
"we",
"propose",
"the",
"designation",
"myeloid/NK",
"acute",
"leukemia",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Recognition",
"of",
"this",
"new",
"leukemic",
"entity",
"will",
"be",
"important",
"in",
"distinguishing",
"these",
"ATRA-nonresponsive",
"cases",
"from",
"ATRA-responsive",
"true",
"APL",
"."
] |
[
3,
0,
3,
0,
0,
3,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"IL-4",
"down-regulates",
"IL-2",
"-",
",",
"IL-3",
"-",
",",
"and",
"GM-CSF",
"-induced",
"cytokine",
"gene",
"expression",
"in",
"peripheral",
"blood",
"monocytes",
"."
] |
[
3,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
6,
6,
6,
6,
6,
6,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
2,
2,
2,
0,
0
] | [
"IL-4",
",",
"a",
"product",
"of",
"the",
"T-helper",
"0",
"(",
"Th0",
")",
"and",
"2",
"(",
"Th2",
")",
"subset",
",",
"was",
"originally",
"described",
"as",
"a",
"B-cell",
"stimulatory",
"factor",
"and",
"has",
"subsequently",
"been",
"found",
"to",
"suppress",
"IL-1",
"alpha",
",",
"IL-1",
"beta",
",",
"IL-6",
",",
"IL-8",
",",
"and",
"TNF-alpha",
"gene",
"expression",
"in",
"monocytes",
"stimulated",
"with",
"LPS",
",",
"and",
"to",
"upregulate",
"IL-1",
"receptor",
"antagonist",
"(",
"IL1-RA",
")",
"gene",
"expression",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
1,
2,
0,
5,
0,
0,
0,
3,
4,
4,
0,
3,
0,
3,
0,
0,
3,
0
] | [
"In",
"this",
"study",
"we",
"investigated",
"the",
"effect",
"of",
"IL-4",
"on",
"the",
"expression",
"of",
"cytokine",
"genes",
"in",
"monocytes",
"evoked",
"by",
"other",
"T-helper",
"cell",
"cytokines",
":",
"IL-2",
",",
"IL-3",
",",
"and",
"GM-CSF",
"."
] |
[
3,
0,
0,
0,
0,
0,
3,
4,
3,
4,
0,
3,
0,
0,
3,
0,
5,
0,
0,
3,
0,
3,
0,
0,
3,
0
] | [
"IL-4",
"down-regulated",
"mRNA",
"accumulation",
"of",
"the",
"proinflammatory",
"cytokines",
"IL-1",
"beta",
",",
"IL-8",
",",
"and",
"TNF-alpha",
"in",
"monocytes",
"stimulated",
"with",
"IL-2",
",",
"IL-3",
",",
"and",
"GM-CSF",
"."
] |
[
3,
0,
0,
0,
3,
0,
3,
0,
0,
0
] | [
"IL-4",
"also",
"suppressed",
"the",
"IL-2",
"-induced",
"IL-6",
"mRNA",
"expression",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0
] | [
"Temporal",
"analysis",
"of",
"the",
"IL-4",
"down-regulatory",
"effect",
"on",
"the",
"IL-2-",
",",
"IL-3-",
",",
"or",
"GM-CSF-induced",
"proinflammatory",
"cytokine",
"gene",
"expression",
"in",
"monocytes",
"provided",
"evidence",
"that",
"IL-4",
"acts",
"predominantly",
"on",
"the",
"post-transcriptional",
"level",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"This",
"was",
"supported",
"by",
"the",
"observation",
"that",
"the",
"down-regulatory",
"capacity",
"of",
"IL-4",
"appeared",
"to",
"be",
"dependent",
"on",
"de",
"novo",
"protein",
"synthesis",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
0,
3,
0,
3,
0,
0,
3,
0
] | [
"IL-4",
"did",
"not",
"exert",
"significant",
"influence",
"on",
"the",
"induction",
"of",
"expression",
"of",
"IL-1-RA",
"or",
"various",
"CSFs",
"by",
"IL-2",
",",
"IL-3",
",",
"and",
"GM-CSF",
"."
] |
[
0,
0,
0,
0,
0,
0,
0
] | [
"(",
"ABSTRACT",
"TRUNCATED",
"AT",
"250",
"WORDS",
")"
] |
[
0,
0,
1,
0,
3,
0,
0,
0,
0,
0,
5,
0,
0,
7,
8,
8,
7,
0,
0,
0,
0,
0,
0,
0
] | [
"Induction",
"of",
"proto-oncogene",
"and",
"cytokine",
"expression",
"in",
"human",
"peripheral",
"blood",
"monocytes",
"and",
"the",
"monocytic",
"cell",
"line",
"THP-1",
"after",
"stimulation",
"with",
"mycoplasma-derived",
"material",
"MDHM",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
5,
6,
6,
0,
0,
3,
0,
0,
5,
6,
0
] | [
"Mycoplasma",
"fermentans-derived",
"high-molecular-weight",
"material",
"(",
"MDHM",
")",
"was",
"originally",
"described",
"to",
"induce",
"differentiation",
"of",
"murine",
"thymocytes",
"to",
"cytolytic",
"effector",
"T-cells",
"by",
"stimulating",
"IL-6",
"release",
"from",
"adherent",
"cells",
"."
] |
Subsets and Splits