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Paired SARS-COV-2 heavy/light chain sequences from the Observed Antibody Space database

Human paired heavy/light chain amino acid sequences from the Observed Antibody Space (OAS) database obtained from SARS-COV-2 studies.

https://opig.stats.ox.ac.uk/webapps/oas/

Please include the following citation in your work:

 Olsen, TH, Boyles, F, Deane, CM. Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences. Protein Science. 2022; 31: 141–146. https://doi.org/10.1002/pro.4205

Data Preparation

This data was obtained on August 3, 2023 by searching the OAS Paired Sequence database with the following criteria:

  • Species = "human"
  • Disease = "SARS-COV-2"

This returned 704,652 filtered sequences from 3 studies split across 63 .csv.gz data unit files. These were extracted and filtered for records where both the complete_vdj_heavy and complete_vdj_light values were "T". Finally, the sequence_alignment_aa_heavy and sequence_alignment_aa_light fields were extracted into dataset and a 90/10 train/test applied. The resulting data was saved in pyarrow format.