True about Pralidoxime ?
Ans. is 'a' i.e., It acts by regenerating acetylcholinesterase enzyme Pralidoxime (and other oximes) acts by reactivating cholinesterase enzyme. Oximes are used for poisoning with organophosphate insectide not for chlorinated insectisides (chlorinate hydrocarbons e.g. DDT, lindane, dieldrin). Some of the war gases are organophosphate compounds e.g. dialkylfuorophosphate, for which oximes can be used. RBC cholinesterase levels reflect enzyme activity better than plasma cholinesterase because: i) Plasma cholinesterase can give falsly high activity if there is RBC hemolysis (RBC cholinesterase comes into plasma) ii) In chornic organophosphate exposure, plasma cholinesterase may return to normal but RBC levels remains depressed.
It acts by regenerating acetylcholinesterase enzyme
It can be used for all chlorinated compounds
It is not used for war gases
Plasma cholinesterase levels signifies better reflection of enzyme activity than RBC levels
It acts by regenerating acetylcholinesterase enzyme