All the following are seen in thalassemia major except:
Ans: c (Low iron content in blood)Serum iron content is increased in thalassaemia major and not decreased.THALASSAEMIA MAJOR / COOLY'S ANAEMIAAge is usually 3-6 monthsRegular, monthly blood transfusion dependentClinical Features* Mainly due to extramedullary erythropoiesis in facial and skull bones -> haemolytic facies* HepatosplenomegalyLab Findings* Peripheral smear- hypochromic microcytic anaemia with bizarre fragmented poikilocytes* Intra erythrocytic inclusions - Heinz bodies Heinz bodies are precipitated extra alpha chain* Hb F increased* TIBC normal* Osmotic fragility is reduced* X ray skull - hair on end appearance.Complications 1) Hypersplenism 2) Haemosiderosis 3) Endocrine complications4) Cardiomyopathy - cause of death# Diabetes mellitus# Hypothyroidism# Delayed puberty5) Hyperpigmentation due to melanin deposition6) Growth retardationTreatmentRegular packed cell transfusionBone marrow transfusion is curative
Blood
Microcytic hypochromic anaemia
Hepatosplenomegaly
Low iron content in blood
None
Low iron content in blood