Which of the following is a most impoant infiltrate in rheumatoid ahritis?
Rheumatoid ahritis - Delayed hypersensitivity - Infiltration caused by CD4+ helper cells - Infiltration contribute to development of pannus - Involvement of small joints - IFN-g from TH 1 cells activates macrophages and resident synol cells. - IL-17 from TH 17 cells recruits neutrophils and monocytes. - TNF and IL-1 from macrophages stimulates resident synol cells to secrete proteases that destroy hyaline cailage. - RANKL expressed on activated T cells stimulates bone resorption. - Of these, TNF has been most firmly implicated in the pathogenesis of RA and TNF antagonists have proved to be remarkable effective therapies for the disease.
NEET 2018
Dendritic cells
Macrophages
Neutrophils
CD4+ Helper cells
CD4+ Helper cells