Mechanism of action of Ezetimibe
Refer kDT 7/e p 641 Ezetimibe is a medication used to treat high blood cholesterol and ceain other lipid abnormalities. Generally it is used together with dietary changes and a statin. Alone, it is less preferred than a statin. It is taken by mouth. It is also available in the combination ezetimibe/simvastatin
Cardiovascular system
Interfere with absorption of bile acids
Interfere CETP
Interfere with the absorption of cholesterol by inhibiting NPCIL1
Inhibitor of PPAR alpha
Interfere with the absorption of cholesterol by inhibiting NPCIL1