Which of the following best describe Anrep effect ?
Anrep effect: - Increased afterload increases cardiac contractility. Autoregulation method in which myocardial contractility increases with afterload. It was experimentally determined that increasing afterload caused a propoional linear increase in ventricular inotropy For instance, when LV has to pump against the aoa pressure, & the aoa pressure is after load on LV. If the after-load increases, then against the increasing resistance LV has to contract & eject out the blood, therefore it needs to go on increasing its contractility, this effect has been called as the Anrep effect. Such contractions are called as - Auxotonic contraction.
Cardiac Cycle
Increased preload decreases cardiac contractility
Increased after load increases cardiac contractility
Increased preload decreases cardiac relaxation
Decreased after load decreases cardiac relaxation
Increased after load increases cardiac contractility