The rationale for sucralfate therapy in peptic ulcers does not include :
A Sucralfate binds to the base of the ulcer crater and inhibits the pepsin mediated protein hydrolysis. It by itself has no acid neutra-lizing action. Other mechanisms proposed for its effect are stimulation of prostaglandin synthesis and stimulation of local epider-mal growth factor.
It has an acid neutralizing action.
It inhibits pepsin mediated protein hydrolysis.
It stimulates the production of epidermal growth factor.
It stimulates prostaglandin synthesis.
It has an acid neutralizing action.