Cytokine for activating macrophage and conveing to epitheloid cell or giant cell ?
Ans. is 'd' i.e., IFN gamma Granulomatous inflammation is a form of chronic inflammation characterized by collections of activated macrophages, often with T lymphocytes, and sometimes associated with central necrosis. These granulomas are type IV hypersensitivity reaction that involves CD4-helper T-cells. Helper T-cells are activated by IL-2 and produce IFN-y (interferon gamma) the major cytokine of granulomatous inflammation. IFN-y induces formation of granuloma by conversion of activated macrophages into epitheloid cells and formation of giant cells by fusion of epithelial cells.
IL2
IL 17
TNF alpha
IFN gamma
IFN gamma