A patient of 47 XXY karyotype presents with features of hypogonadism; likely diagnosis is :
Ans. is b i.e. Klinefelter syndrome Extra Edge : Klinefelter's syndrome ? Seen in 1 : 500 malesdeg Karyotype 47XXY (1 barr body present)deg Phenotype maledeg Gonads : Testis, small but normally placeddeg Genitalia : Penis is small/ normal size. Gynaecomastia is frequently seendeg Sterility is commondeg Voice : High pitched and appearance may be eunuchoid Patient is mentally defective or delinquentdeg. Testicular biopsy shows hyaline degeneration of seminiferous tubules and over growth of leydig cells, as a result of which stelirity is so often the presenting symptom The person should be broughtup as male.deg Treatment with testosterone may help.
Turners syndrome
Klinefelters syndrome
Edwards syndrome
Down syndrome
Klinefelters syndrome