First order kinetics is characterized by:
First order (exponential) kinetics; The rate of elimination is directly propoional to the drug concentration, Clearance remains constant, or a constant fraction of the drug present in the body is eliminated in unit time. Ref:KD Tripathi pharmacology 7th edition (page.no: 30)
General pharmacology
Dose independent elimination
Decreasing clearance as plasma concentration increases
Increasing rate of elimination as plasma concentration increases
No relationship between rate of elimination and plasma concentration
Increasing rate of elimination as plasma concentration increases