Which of the following drugs act by inhibiting granulocyte migration?
Ans (A) Colchicine(Ref: Goodman and Gilman 13th/702-703)Colchicine is more effective and faster acting than NSAIDs but is used rarely due to its high toxicity.It acts by inhibiting granulocyte migration into the in- flamed joint.It causes metaphase arrest (other drugs causing meta- phase arrest are vinca alkaloids, ixabepilone and taxanes).Most common and dose limiting toxicity is diarrhea.It can also cause kidney damage, myopathy and bone marrow depression.
Immunomodulator
Colchicine
Montelukast
Cromoglycate
Allopurinol
Colchicine