Which of the following is FALSE regarding Neurofibromatosis inheritance:
NEUROFIBROMATOSIS (NF) NF - 1/Von Recklinghausen's Disease NF-2/Bilateral acoustic neurofibromatosis Most common single gene disorder affecting human nervous system. Peripheral neurofibromatosis, is due to defect in chromosome 17. AD inheritance 100% penetrance Due to defect in long arm of chromosome 22. AD inheritance Musculoskeletal deformities absent 8th nerve vestibular schwannomas Meningioma occur in 50% cases. Note: Usually Skeletal disorders are Autosomal Dominant and Inborn errors of metabolism are autosomal recessive
Amyotrophic Lateral Sclerosis and other motor neuron diseases
Von Recklinghausen's Disease is due to defect in chromosome 17
Autosomal dominant type of inheritance
NF-2 - Musculoskeletal deformities is characterstic
NF-1 - Most common single gene disorder affecting human nervous system.
NF-2 - Musculoskeletal deformities is characterstic