Which of the following statments about the biodisposition of penicillins and cephalosporins is NOT accurate?
(Ref: KDT 6/e p697) Probenecid inhibits renal tubular secretion of penicillins (not reabsorption) Beta lactams eliminated by biliary route are: - Ampicillin - Nafcillin - Ceftriaxone - Cefoperazone Penicillin G has to be given by i.m. route because it is broken down by gastric acid (decreases oral bioavailability).
Other topics and Adverse effects
Oral bioavailability is affected by lability to gastric acid
Procaine penicillin G is used intramuscular injection
Renal tubular reabsorption of beta-lactams is inhibited by probenecid
Nafcillin and ceftriaxone are eliminated minly biliary secretion
Renal tubular reabsorption of beta-lactams is inhibited by probenecid