Mechanism of action of paclitaxel is -
Ans. is 'b' i.e., Increases the polymerization of tubulin o Paclitaxel and docetaxel function as a mitotic spindle poison through high affinity binding to microtubules with enhancement of tubulin polymerization. o The microtubules are stabilized and their depolymerization is prevented inhibition of mitosis and cell division.
Topoisomerase inhibition
Increases the polymerization of tubulin
Inhibits protein synthesis
Alkylation of DNA
Increases the polymerization of tubulin