A45 yr old patient present with history of fever .night sweat ,weight loss. On x Ray a mass in apical love of lung is seen.on histopathology it was found to have caseous nercrosis . What is the likely underlying process involved
Ref Robbins 9/e p272 Presence of history of fever, night sweat and weight loss with apical lesson having caseous necrosis is a pointer to the presence of tuberculosis in the patient.this is characterised by the stimulation of the macrophages to kill mycobacteria.the TH2 response leading to the formation of granuloma is a feature of type 4 hypersensitivity reaction
General anatomy
Enzymatic degeneration
Hypersensitivity reaction with modified macrophages, lymphocytes and giant cells
Acute decrease in blood supply
Decreased supply of growth factor
Hypersensitivity reaction with modified macrophages, lymphocytes and giant cells