Pancuronium differs from tubocurarine in that:
* Pancuronium possesses vagolytic activity and can cause hypeension and tachycardia on rapid i.v. injection. * Pancuronium is a competitive NM blocker (Non-depolarizing NM blocker). Its actions can be reversed by anticholinesterases like neostigmine. * Unlike d-TC, histamine release is not seen with pancuronium.
Anaesthesia
It is a depolarizing blocker
Its action is not reversed by neostigmine
It can cause rise in BP on rapid I.V. injection
It causes marked histamine release
It can cause rise in BP on rapid I.V. injection