Imatinib is useful in treatment of ?
Ans. is 'b' i.e., CD 117 positive GIST GIST cells are positive for CD-1I7 (C-KIT). o Mutation in C-KIT results in continuous activation of receptor tyrosine kinase. o Imatinib inhibits tyrosine kinase activity of C-KIT --> Imatinib is used in GIST o Patients who develop resistance to imatinib may respond to the multiple tyrosinase kinase inhibitor sunitinib.
Neuro fibromatosis
CD 117 positive GIST
Neuroendocrine tumor of pancreas
Breast Ca
CD 117 positive GIST