Lubiprostone is a:
Lubiprostone :- selectively stimulates type 2 chloride channels in epithelial cells thereby causing an efflux of chloride into the intestinal lumen. - The resultant fluid secretion into the gastrointestinal lumen provides a bolus effect that softens stool, increases intestinal transit, and improves symptoms of constipation. - Lubiprostone acts locally within the intestinal tract, is rapidly metabolized, and has very low systemic bioavailability.
JIPMER 2017
Chloride channel activator
Chloride channel inhibitor
Sodium channel activator
Sodium channel inhibitor
Chloride channel activator