Activated protein C inhibit clotting mechanism by inactivating which of the following clotting factors:
Protein-C is a vitamin K-dependent protease that requires a cofactor (Protein S). Activated Protein C/protein S forms a complex which is a potent inhibitor of coagulation factors Va and Factor VIIIa. Protein C acts as a Tissue factor pathway inhibitor (TFPI)
Clotting system
Factor IIIa and Factor VIIIa
Factor VIIIa and Factor IXa
Factor Va and Factor VIIIa
Factor Va and Factor VIIa
Factor Va and Factor VIIIa