Apparent volume of distribution (Vd) of a drug exceeds total body fluid volume, if a drug is:
Ans. (A) Sequestered in body tissues(Ref: KDT 8th/e p24)* Apparent volume of distribution (Vd ) is more for drugs sequestered in tissues.* Lipid insoluble drugs do not enter cells, Vd approximates ECF volume.
General Pharmacology
Sequestrated in body tissues
Slowly eliminated from body
Poorly soluble in plasma
Highly bound to plasma proteins
Sequestrated in body tissues