A four year old boy was admitted with a history of abdominal pain and fever for two months maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination liver and spleen were enlarged 4 cm and 3 cm respectivley below the costal margin. His hemoglobin was 10.0 g/dl, platelet count 3.7 x 109/L and total leukocyte count 70 x 109/L, which included 80% eosinophils Bone marrow examination revealed a cellular marrow comprising of 45% blasts and 34% Eosinophils and eosinophil precursors. The blasts stained negative for my eloperoxidase and nonspecific esterase and were positive for C D19, CD10, CD22 and CD20. Which one of the following statements is not true about disease?
Eosinophils are not part of the Neoplastic clone.
t(5:14) rearrangement may be detected in blasts.
Peripheral blood eosinophilia may normalize with chemotherapy
Inv (16) is often detected in the blasts and the eosinophils
Inv (16) is often detected in the blasts and the eosinophils