Loss of foot processes of podocytes is characteristically seen in?
Ans. is 'b' i.e., Lipoid nephrosis * Effacement (loss) of foot process of perietal epithelial cells (podocytes) is most commonly noted in minimal change disease (lipoid nephrosis).* However, it may be seen other causes of nephrotic syndrome like membronous GN, FSGS, IgA nephropathy (a type of mesangioproliferative GN), and MPGN.Pathological findings of lipoid nephrosis1) Light microscopy - No abnormality2) Electron microscopy - Obliteration (loss) and fusion of foot processes of epithelial cells.3) Immunofluorescence - No deposits of immune reactants4) Serum complements - Normal levels* The basic pathogenesis of minimal change glomerulonephritis is loss of the basement membrane polyanion (Heparan sulfate proteoglycan).* Loss of the polyanion reduces the negative charge in membrane which allows anionic molecules of the plasma (Albumin) to pass through.
Kidney
Good pasture syndrome
Lipoid nephrosis
PSGN
Lupus nephritis
Lipoid nephrosis