Which of the following is the characteristic of a highly ionized drug?
A highly ionized drug is not reabsorbed by the tubules and is easily excreted by the kidneys because it is lipid insoluble. Ref: Dr J G Buch, (2010) Chapter 3, "Pharmacokinetics", "Clinically oriented pharmacology", Newdelhi, Page 13
High protein binding
Can cross placental barrier easily
Rapidly absorbed from stomach
Excreted mostly by the kidneys
Excreted mostly by the kidneys