Paial agonist can antagonise the effects of a full agonist because it has
Agonists:- Have both affinity and maximal intrin-sic activity. Competitive antagonists :- Have affinity but no intrinsic activity. Paial agonists:- Have affinity and submaximal intrinsic activity. Inverse agonists:- Have affinity but intrinsic activity with a minus sign (IA between 0 and -1). Ref:- kd tripathi; pg num:-41,42
General pharmacology
High affinity but low intrinsic activity
No affinity and low intrinsic activity
Low affinity but high intrinsic activity
High affinity but no intrinsic activity
High affinity but low intrinsic activity