Causes of severe hypokalemic metabolic alkalosis with severe hypeension include
Liddle syndrome - AD, gain-in-function mutations of ENaC subunits. Activating kidneys to excrete potassium retaining excessive sodium & water, leading to hypeension. C/F- severe hypeension with hypokalemia, unresponsive to spironolactone yet sensitive to amiloride
Bater syndrome, Gitelman syndrome, Liddle and Comparison with SIADH
Liddle syndrome
Bater syndrome
Gitelman syndrome
Renal tubular acidosis
Liddle syndrome