Primary abnormality in sequence of events leading to DIC is-
The sequence of events in DIC are: activation of coagulation, thrombotic phase,consumption phase,secondary fibrinolysis. Massive tissue injury ,infections ,widespread endothelial damage stimulates widespread activation of coagulation pathway bye release of tissue factor & uncontrolled thrombin generation is the primary pathway.Reference:Harsh mohan textbook of pathology sixth edition pg no 337
Haematology
Fibrin deposits in multiple sites
Uncontrolled thrombin generation
Abnormal adhesion and consumption ofplatelets
Destruction of red cells
Uncontrolled thrombin generation