glipizide differs from chlorpropamide in that it:
(Ref: KDT 6/e p266) Second generation (like glipizide) sulfonylureas are more potent than first generation agents (like chlorpropamide). Chlorpropamide is the longest acting sulfonylurea. Sulfonylureas can cause hypoglycemia (even in non-diabetics) due to release insulin.
Other topics and Adverse effects
Is more potent
Is longer acting
Does not lower blood sugar in nondiabetic subjects
Is less prone to cause hypoglycemic reaction
Is more potent