All of the following are true about Alzheimer's disease except?
Extracellular inclusions CANNOT be found in absence of intracellular inclusions. Neuritic plaques and neurofibrillary changes are found in all associated areas of the cerebral coex. Number of neuritic senile plaques correlate with age. Neuritic plaques can be seen in the normal aged brain also, so they are non-pathogenic in all cases. Neurofibrillary tangles and neuronal alterations correlate best with the severity of dementia, not neuritic plaques. Tau proteins are formed intracellularly causing neuronal degeneration leading to Alzheimer disease.
Guillian Barre syndrome & Alzheimer's disease
Number of senile plaques correlate with age
Underlying tau proteins suggest neurodegeneration
Number of neurofibrillary tangles is associated with the severity of dementia
Extracellular inclusions can be found in the absence of intracellular inclusions
Extracellular inclusions can be found in the absence of intracellular inclusions