Botulinum toxin acts on:
(Ref: KD Tripathi, 7th ed. pg. 99)Release of Ach from nerve terminals occurs in small quanta--amount contained in individual vesicles is extruded by exocytosis.Two toxins interfere with cholinergic transmission by affecting release:# Botulinum toxin inhibits release# Black widow spider toxin induces massive release and depletionBotulinum toxin# Botulinum toxin A and B are highly potent exotoxins produced by Clostridium botulinum that are responsible for 'botulism' (a type of food poisoning). These neurotoxic proteins cause long-lasting loss of cholinergic transmission by interacting with axonal proteins involved in exocytotic release of Ach.
A.N.S.
Inhibition of release of neurotransmitter
Post synaptic block
At synapse
Reuptake inhibitor
Inhibition of release of neurotransmitter