In malignant hypehermia, excess heat production is due to:
Malignant hypehermia is an autosomal-dominant disease in which the defect is in RyR1 gene. When such individuals are administered inhalation anaesthetics (halothane or ether) or muscle relaxant succinylcholine , there is excess release of Ca++ in the sarcoplasm. This increases muscle metabolism.
Muscle
Increased muscle metabolism by excess of calcium ions
Thermic effect of food
Increased sympathetic discharge
Mitochondrial thermogenesis
Increased muscle metabolism by excess of calcium ions