Glanzman's thromboasthenia is characterized by defective -
Ans is 'a' Gp IIB/IIIA Glanzman's thrombastheniao It is an autosomal recessive disorder due to deficiency/dysfunction of glycoprotein Ilb-IIla (Gp Ilb/IIIa). Thus there is defective platelet aggregation.o Platelet aggregation is normal to ristocetin(ln constant to Bernard soulier syndrome) but no aggregation occurs in response to standard agonists (collagen, A DP, thrombin).o Other differentiating features include normal platelet count and morphologyo BT is prolonged. vWF is normal.o The disease manifests at birth with increased bleeding from umbilical cord stump.
Bleeding Disorders
Gp IIB/IIIA
Gp IB/IX
Gp IB/IIIA
GpIIB/IX
Gp IIB/IIIA