Which of the functions are TRUE regarding C-terminal domain of androgen receptor protein?
The androgen receptor proteins contain 3 common domains: 1- Highly conserved central domain that is responsible for DNA binding 2- N-terminal region that is involved in trascriptional activation, and 3- C-terminal domain that binds ligand Ref: Harper's Illustrated Biochemistry 27th Edition, Page 477; Molecular cell biology, December 19 (12); 8383 - 8392; Urotext Basics By R. A. S. Hemat, Edition 2003, Page 68.
Ligand binding
Increasing biological half life
Increasing the affinity of receptor to DNA
Increasing the level of transcription
Ligand binding