The recently approved antiepileptic drug lacosamide acts by:
(Ref: Katzung, 14th ed. pg. 417)* CRMP is Collapsing Response Mediator Protein, which causes neuronal excitotoxicity by releasing BDNF (Brain Derived Neurotropic Factor).* The drug Lacosamide acts by inhibiting CRMP protein, thereby causing protective action against neuronal excitotoxicity.
C.N.S
Inhibiting synaptic vesicular protein
Inhibing CRMP protine
Inhibing GABA metabolism
Inhibing glutamate release
Inhibing CRMP protine