Loading dose depends on the following factors except:
* Loading dose= volume of distribution x target plasma concentration/fractional bioavailability. * Maintenance dose= clearance x target plasma concentration/fractional bioavailability. * So the answer is clearance as it determines maintenance dose instead of loading dose.
Pharmacodynamics
Drug concentration to be achieved
Volume of distribution
Clearance of the drug
Bioavailability of drug
Clearance of the drug