Diagnosis of x linked agammaglobulinamia should be suspected if
Ref Robbins 9/e p240-241 Classically, this disease is characterized by the following: * Absent or markedly decreased numbers of B cells in the circulation, with depressed serum levels of all classes of immunoglobulins. The numbers of pre-B cells in the bone marrow may be normal or reduced. * Underdeveloped or rudimentary germinal centers in peripheral lymphoid tissues, including lymph nodes, Peyer patches, the appendix, and tonsils * Absence of plasma cells throughout the body * Normal T cell-mediated responses
General anatomy
Absent tonsils and no palpable lymph nodes on physical examination
Female sex
High iso hemagglutinin titers
Low CD3
Absent tonsils and no palpable lymph nodes on physical examination