Fever associated with infection
Fever right shifts the oxygen dissociation curve, which allows for a greater release of oxygen to the tissue, making oxygen easily available to neutrophils and monocytes for use in the oxygen-dependent myeloperoxidase system of bactericidal killing. Having more oxygen available to tissue also enhances wound healing. In addition, fever interferes with bacterial and viral replication by providing a hostile environment for incubation. Fever is produced by the release of interleukin-I from macrophages. Interleukin-I, in turn, stimulates the hypothalamus to synthesize prostaglandins, which interact with the thermoregulatory center to produce fever.
General physiology
Accelerates bacterial and viral replication
Left shifts the oxygen dissociation curve
Is due to interleukin-1 released from CD4 T-helper cells
Increase oxygen release to tissue
Increase oxygen release to tissue