Which of the follwing statements regarding drugs used in leprosy is FALSE?
(Ref: KDT 6/e p752, 753) Acedapsone is a repository form od dapsone. Single i,m. injection of acedapsone keep on releasing the drug for 3 months. Rifampicin is used once in a month (supervised dose) for the treatment of leprosy. It prevents the emergence of resistance to dapose. Clofazimine can result in skin pigmentation, disclolouration of secretions and dryness of skin (icthyosis). Clofazimine has no cross-allergenicity with dapsone.
Other topics and Adverse effects
Single intramuscular injections of acedapsone maintain inhibitory levels of dapsone in tissues for upto 3 months
Monthly doses of rifampicin delay the emergence of resistance to dapsone
Clofazimine should not be given to patients who are intolerant to dapsone or who fail to improve during treatment with dapsone
Clofazimine may cause changes in the skin colour
Clofazimine should not be given to patients who are intolerant to dapsone or who fail to improve during treatment with dapsone