True statement about first order kinetics is
Ans. (D) The rate of elimination is proportional to the plasma concentration (Ref: KDT 8th/e p38)Drugs may follow zero order or first order kinetics. It depends on the following formula:Rate of Elimination a {PlasmaConcentration}order* Thus, if a drug follows zero order kinetics, {PlasmaConcentration}0 is equal to one, in other words rate of elimination is independent of plasma concentration or rate of elimination is constant.* From the above formula, rate of elimination is proportional to plasma concentration for the drugs following first order kinetics.
General Pharmacology
A constant amount of a drug is eliminated in unit time
The half-life increases with an increase in dose
The rate of elimination is constant
The rate of elimination is proportional to the plasma concentration
The rate of elimination is proportional to the plasma concentration