Tubocurare affects which muscle first?
Sequence of blockade : face - jaw- pharynx - larynx - respiratory (including diaphragm) - trunk muscle - limb muscle. Face muscles are involved earliest. 1)in non-depolarising blocker (d-Tc), earliest clinical sign is Ptosis and diploia 2)In succinylcholine (depolarising blocker ),First clinical sign is Fasciculation of eye lids.
Muscle relaxants
Head and neck
Limbs
Respiratory muscles
Abdominal muscles
Head and neck