Electron microscopic feature of minimal change disease is?
Ans. b (Loss of foot process of podocytes). (Robbin, Pathology, 8th ed., 543)Minimal-Change Disease (Lipoid Nephrosis)# This relatively benign disorder is the most frequent cause of the nephrotic syndrome in children.# It is characterized by glomeruli that have a normal appearance by light microscopy but show diffuse effacement of podocyte foot processes when viewed with the electron microscope.# Although it may develop at any age, this condition is most common between ages 1 and 7 years.# When the changes in the podocytes reverse (e.g., in response to corticosteroids), the proteinuria remits.
Kidney
No change seen
Loss of foot process of podocytes
Diffuse glomerulosclerosis
Thickened basement membrane
Loss of foot process of podocytes