akramRedjdal/CHIA_Dataset_ProjetE4_BIO4304A

tokens sequencelengths 0 1.12k	labels sequencelengths 0 1.12k
[ "Contraindication", "for", "the", "use", "of", "corticosteroids", "or", "local", "anesthetics", "Presence", "of", "inflammatory", "arthropathy", "or", "neuropathy", "Skin", "lesions", "in", "the", "area", "diabetes", "mellitus", "Infiltration", "or", "previous", "surgery", "in", "the", "area", "Refusal", "to", "participate", "in", "the", "study" ]	[ "B-Condition", "O", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "known", "allergy", "to", "any", "of", "drugs", "used", "coagulopathy", "any", "wound", "or", "infection", "related", "to", "puncture", "site", "major", "illness", "failure", "to", "gain", "consent", "of", "parents", "." ]	[ "O", "B-Condition", "O", "O", "O", "B-Drug", "I-Drug", "B-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "B-Observation", "I-Observation", "I-Observation", "I-Observation" ]
[ "Non-", "English", "speakers", "Height", "<", "4", "'", "11", "''", "BMI", ">", "40", "Kg/", "mm", "Antiemetic", "drug", "use", "in", "the", "24", "hours", "prior", "to", "cesarean", "delivery", ",", "Hypertensive", "diseases", "of", "pregnancy", "Chronic", "hypertension", "receiving", "antihypertensive", "treatment", "Any", "other", "physical", "or", "psychiatric", "condition", "that", "may", "impair", "their", "ability", "to", "cooperate", "with", "study", "data", "collection", "." ]	[ "B-Observation", "I-Observation", "I-Observation", "B-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "B-Drug", "I-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "diabetes", "mellitus", "secondary", "hypertension", "pregnancy" ]	[ "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition" ]
[ "Active", "alcohol", "or", "drug", "use", "or", "dependence", "which", "may", "interfere", "with", "adherence", "to", "study", "requirements", "HIV-infected", "at", "screening", "or", "enrollment", "Estimated", "CrCl", "<", "60", "mL/min", "Past", "participation", "in", "an", "HIV", "vaccine", "study", "Positive", "Hepatitis", "B", "surface", "antigen", "test", "Underlying", "medical", "condition", "with", "survival", "unlikely", "during", "follow-up", "period", "Any", "condition", "that", "in", "the", "opinion", "of", "study", "staff", "would", "make", "participation", "in", "the", "study", "unsafe", "or", "interfere", "with", "achieving", "study", "objectives", "Pregnant", "or", "breast", "feeding", "Actively", "trying", "to", "achieve", "pregnancy" ]	[ "B-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "B-Condition", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Observation", "I-Observation", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations" ]
[ "No", "consent", "Spinal", "anesthesia", "or", "sciatic", "nerve", "block", "contraindicated", "Known", "intolerance", "to", "tramadol", "or", "other", "contraindications", "for", "the", "drug" ]	[ "B-Informed_consent", "B-Observation", "B-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Qualifier", "B-Condition", "I-Condition", "B-Drug", "I-Drug" ]
[ "diagnosed", "advanced", "heart", ",", "kidney", "or", "liver", "failure", "benign", "prostatic", "hyperplasia", "prostatic", "carcinoma", "frequent", "urinary", "tract", "infections", "non-type", "1", "diabetes", "mellitus" ]	[ "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Multiplier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition" ]
[ "Persistent", "primary", "or", "recurrent", "trans-sphincteric", "anal", "fistula" ]	[ "O", "B-Multiplier", "O", "B-Multiplier", "B-Condition", "I-Condition", "I-Condition" ]
[ "Patients", "with", "SOF/VEL", "treatment", "for", "the", "treatment", "of", "chronic", "HCV", "genotype", "1", "through", "6", ".", "Patient", "is", "at", "least", "18", "at", "the", "day", "of", "screening", ".", "Patient", "is", "able", "and", "willing", "to", "sign", "the", "Informed", "Consent", "Form", ".", "Patient", "is", "able", "and", "willing", "to", "follow", "protocol", "requirements", "." ]	[ "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Qualifier", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "Cardiac", "morbidities", "Hypertensive", "disorders", "of", "pregnancy", ",", "Peripartum", "bleeding", "Baseline", "systolic", "blood", "pressure", "(", "SBP", ")", "<", "100", "mmHg", "Body", "mass", "index", ">", "35" ]	[ "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement" ]
[ "Age", "=", "18", "years", "Laparoscopic", "cholecystectomy", "Emergent/elective", "=2", "risk", "factors", ":", "diabetes", "mellitus", ",", "age", "=70", "years", ",", "BMI", "=30", ",", "fascial", "enlargement" ]	[ "B-Person", "B-Value", "I-Value", "I-Value", "B-Qualifier", "B-Procedure", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Person", "B-Value", "I-Value", "I-Value", "B-Measurement", "B-Value", "B-Condition", "I-Condition" ]
[ "Adult", "male", "and", "female", "aged", "19", "to", "75", "years", "Voluntarily", "consented", "to", "participate", "in", "the", "study", "and", "signed", "the", "informed", "consent", "form", "after", "receiving", "the", "explanation", "of", "the", "objectives", ",", "methods", "and", "effects", "of", "the", "study", "." ]	[ "O", "B-Person", "O", "B-Person", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]
[ "Age", "<", "1m", "or", ">", "24", "months", "of", "age", "No", "secure", "diagnosis", "of", "epilepsy", "<", "4", "seizures/week", "on", "average", "in", "baseline", "period", "Trial", "of", "<", "2", "AEDs", "Continues", "on", "corticosteroids", "in", "previous", "3", "months", "prior", "to", "randomisation", "Metabolic", "disease", "contraindicating", "use", "of", "the", "ketogenic", "diet", "e.g", ".", "pyruvate", "carboxylase", "deficiency", ",", "MCAD", "from", "previous", "medical", "investigation", "and", "screening", "at", "baseline", ".", "Progressive", "neurological", "disease", "Severe", "gastroesophageal", "reflux", "Previous", "treatment", "with", "the", "ketogenic", "diet", "Concurrent", "participation", "in", "another", "clinical", "trial", "of", "an", "investigational", "medicinal", "product", ".", "Patients", "who", "are", "prescribed", "AEDs", "not", "listed", "in", "the", "trial", "IMPs" ]	[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "O", "O", "O", "B-Condition", "O", "B-Multiplier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "O", "O", "B-Procedure", "I-Procedure", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]
[ "Anticoagulant", "therapy", "during", "the", "past", "1", "week", "of", "the", "procedure", "Known", "coagulopathy", "History", "of", "liver", "cirrhosis", ",", "chronic", "kidney", "disease", ",", "malignancy", ",", "inflammatory", "bowel", "disease", ",", "significant", "infectious", "disease", ",", "polyposis", "syndrome" ]	[ "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Reference_point", "O", "B-Condition", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition" ]
[ "Prevalent", "NHHD", "patients", "who", "have", "received", ">", "1", "year", "dialysis", "with", "unfractionated", "heparin", "as", "anticoagulant", "Age", ">", "=", "18", "Informed", "consent", "available" ]	[ "O", "B-Condition", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "B-Procedure", "O", "B-Drug", "I-Drug", "O", "B-Drug", "B-Person", "O", "B-Value", "I-Value", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]
[ "History", "of", "significant", "head", "trauma", ",", "seizure", "disorder", ",", "or", "mental", "retardation", "History", "of", "alcohol", "or", "drug", "abuse", "or", "dependence", "within", "1", "month", "prior", "to", "study", "entry", "History", "of", "violence", "within", "6", "months", "prior", "to", "study", "entry" ]	[ "B-Temporal", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "O", "O", "O", "B-Condition", "B-Condition", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Temporal", "O", "B-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O" ]
[ "Children", "will", "be", "excluded", "if", "they", "have", "a", "history", "of", "developmental", "delay", "or", "inability", "to", "communicate", "the", "effects", "of", "an", "allergic", "reaction", "(", "non-verbal", ")", ".", "Any", "contraindication", "to", "allergy", "testing", "will", "also", "result", "in", "exclusion", "(", "i.e", ".", "history", "of", "a", "severe", "allergic", "reaction", "to", "skin", "tests", ",", ",", "anaphylaxis", "in", "the", "past", "six", "weeks", ",", "pregnancy", ",", "child", "took", "any", "antihistamine", "in", "the", "past", "three", "days", "[", "including", "diphenhydramine", "(", "Benadryl®", ")", ",", "cetirizine", "(", "Zyrtec®", ")", ",", "loratadine", "(", "Claritin®", ")", ",", "fexofenadine", "(", "Allegra®", ")", ",", "levocetirizine", "(", "Xyzal®", ")", ",", "and", "desloratadine", "(", "Clarinex®", ")", "]", "or", "child", "has", "a", "history", "of", "a", "condition", "that", "requires", "a", "beta", "blocker", "medicine", "for", "cardiac", "conditions", ",", "high", "blood", "pressure", ",", "migraine", "headaches", ",", "or", "eye", "drops", "for", "glaucoma", "(", "e.g", ".", "propranolol", ",", "metoprolol", ",", "atenolol", "and", "Timoptic®", ",", "or", "Betoptic®", "eye", "drops", ")", ".", "Children", "who", "present", "to", "the", "PED", "with", "a", "rash", ",", "vomiting", "or", "current", "asthma", "symptoms", "including", "coughing", ",", "wheezing", "or", "breathing", "problems", "will", "also", "be", "excluded", "to", "ensure", "these", "do", "not", "mask", "reactions", "to", "an", "oral", "challenge", ".", "Patients", "being", "admitted", "to", "the", "hospital", "or", "those", "who", "are", "deemed", "too", "acutely", "ill", "for", "participation", "(", "triage", "level", "1", "or", "2", "or", "as", "determined", "by", "the", "ED", "patient", "care", "team", ")", "will", "be", "excluded", "from", "the", "study", ".", "During", "this", "pilot", "study", ",", "we", "will", "exclude", "non-English", "speaking", "families", ".", "However", ",", "in", "subsequent", "studies", "we", "will", "include", "the", "non-English", "speaking", "population", ".", "Children", "who", "are", "wards", "of", "the", "state", ",", "in", "foster", "care", "or", "police", "custody", "or", "detention", "will", "be", "excluded", ".", "Children", "with", "any", "basal", "condition", "(", "trauma", ",", "infection", ",", "minor", "accidents", ",", "etc", "..", ")", "will", "be", "able", "to", "participate", "in", "the", "study", "provided", "they", "and", "their", "family", "are", "willing", "and", "do", "not", "meet", "the", "above-mentioned", "exclusion", "criteria", "." ]	[ "B-Person", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "O", "O", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Person", "I-Person", "I-Person", "O", "O", "O", "B-Visit", "I-Visit", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "O", "O", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "After", "half-dose", "ticagrelor", "(", "loading", "dose", "90mg", ",", "and", "then", "45mg", "bidpo", ".", ")", "treatment", "for", "3", "days", ",", "the", "platelet", "aggregation", "is", "effectively", "inhibited", "by", "light", "transmission", "aggregometry", "method", "and", "thromboela-stogram", ".", "planned", "to", "undergo", "PCI", "recently", "planned", "to", "DAPT", "for", "1", "year", "after", "PCI" ]	[ "O", "B-Multiplier", "B-Drug", "O", "B-Measurement", "I-Measurement", "B-Value", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Qualifier", "B-Value", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Procedure", "O", "B-Mood", "I-Mood", "I-Mood", "B-Procedure", "B-Temporal", "B-Mood", "I-Mood", "B-Procedure", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Temporal", "B-Reference_point" ]
[ "Patient", "refusal", "for", "supraclavicular", "block", "Inability", "to", "give", "informed", "consent", "Allergy", "to", "local", "anesthetics", "Hemidiaphragmatic", "dysfunction", ",", "suspected", "or", "known", "PNP", "Neuromuscular", "disease", "Obstructive", "or", "restrictive", "pulmonary", "disease", "Medical", "or", "anatomic", "contraindication", "to", "supraclavicular", "blockade", "as", "judged", "by", "clinician", "Pregnancy" ]	[ "B-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "B-Non-representable", "I-Non-representable", "I-Non-representable", "B-Condition" ]
[ "1", ".", "Prior", "Therapy", "Exposure", "to", "chemotherapy", "or", "radiotherapy", "within", "2", "weeks", "prior", "to", "entering", "the", "study", "or", "those", "who", "have", "not", "recovered", "from", "adverse", "events", "due", "to", "agents", "administered", "more", "than", "2", "weeks", "earlier", ".", "Systemic", "steroids", "that", "have", "not", "been", "stabilized", "(", "≥", "5", "days", ")", "to", "the", "equivalent", "of", "≤10", "mg/day", "prednisone", "prior", "to", "the", "start", "of", "the", "study", "drugs", ".", "No", "other", "investigational", "agents", "are", "allowed", ".", "2", ".", "History", "of", "allergic", "reactions", "to", "TGR-1202", "or", "carfilzomib", "3", ".", "Uncontrolled", "inter-current", "illness", "4", ".", "Pregnant", "women", "5", ".", "Nursing", "women", "6", ".", "Current", "malignancy", "or", "history", "of", "a", "prior", "malignancy", "7", ".", "Patient", "known", "to", "be", "Human", "Immunodeficiency", "Virus", "(", "HIV", ")", "-positive", "8", ".", "Active", "Hepatitis", "A", ",", "Hepatitis", "B", ",", "or", "Hepatitis", "C", "infection" ]	[ "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "B-Negation", "B-Condition", "O", "B-Condition", "I-Condition", "B-c-Requires_causality", "I-c-Requires_causality", "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Drug", "I-Drug", "O", "O", "B-Negation", "O", "B-Qualifier", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Multiplier", "I-Multiplier", "B-Drug", "B-Temporal", "I-Temporal", "O", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Grammar_Error", "B-Drug", "I-Drug", "I-Drug", "I-Grammar_Error", "I-Grammar_Error", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Drug", "O", "B-Drug", "B-Parsing_Error", "I-Parsing_Error", "B-Undefined_semantics", "B-Condition", "I-Condition", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "B-Person", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "B-Person", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "B-Parsing_Error", "I-Parsing_Error", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Parsing_Error", "I-Parsing_Error", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O" ]
[ "<", "37", "weeks", "gestation", ",", "H/o", "Cesarean", "Section", ",", "Multiple", "Gestation", ",", "Pre-eclampsia", ",", "Narcotics", "within", "3", "hours", "prior", "to", "labor", "epidural", "placement", ",", "Chronic", "Pain", "(", "as", "defined", "by", "chronic", "opiate", "consumption", ")", ",", "Women", "who", "are", "participating", "in", "another", "study", "that", "will", "impact", "protocol" ]	[ "B-Value", "I-Value", "I-Value", "B-Measurement", "O", "B-Observation", "B-Procedure", "I-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Multiplier", "B-Drug", "O", "O", "O", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial" ]
[ "major", "elective", "gastrointestinal", ",", "gynecological", ",", "prostate", "or", "bladder", "surgery", "patients", "who", "are", "=", "60", "years", "old", ".", "the", "surgery", "is", "laparoscopic", "surgery", "and", "is", "expected", "to", "last", "for", "=", "2", "hours", "under", "general", "anesthesia", "and", "the", "patient", "will", "stay", "in", "hospital", "for", "at", "least", "7", "days", "after", "surgery", ".", "lack", "of", "serious", "hearing", "and", "vision", "impairment", "and", "be", "able", "to", "read", "so", "that", "neurobehavioral", "tests", "can", "be", "performed", "." ]	[ "O", "B-Qualifier", "B-Procedure", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Value", "I-Value", "I-Value", "B-Person", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Mood", "O", "B-Measurement", "O", "O", "B-Value", "I-Value", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "I-Negation", "I-Negation", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Mood", "I-Mood", "I-Mood", "I-Mood" ]
[ "Use", "of", "any", "investigational", "or", "non-registered", "product", "(", "drug", "or", "vaccine", ")", "other", "than", "the", "study", "vaccine", "(", "s", ")", "within", "30", "days", "preceding", "the", "first", "dose", "of", "study", "vaccine", ",", "or", "planned", "use", "during", "the", "study", "period", "Chronic", "administration", "(", "defined", "as", "more", "than", "14", "days", ")", "of", "immunosuppressants", "or", "other", "immune-modifying", "drugs", "within", "six", "months", "prior", "to", "the", "first", "vaccine", "dose", ".", "Planned", "administration/", "administration", "of", "a", "vaccine", "not", "foreseen", "by", "the", "study", "protocol", "during", "the", "period", "starting", "one", "month", "before", "each", "dose", "of", "vaccine", "(", "s", ")", "and", "ending", "7", "days", "after", "dose", "1", "and", "dose", "2", "or", "1", "month", "after", "dose", "3", ".", "Previous", "vaccination", "against", "diphtheria", ",", "tetanus", ",", "pertussis", ",", "polio", ",", "hepatitis", "B", ",", "Haemophilus", "influenzae", "type", "b", ",", "and/or", "S.", "pneumoniae", "with", "the", "exception", "of", "vaccines", "where", "the", "first", "dose", "can", "be", "given", "within", "the", "first", "two", "weeks", "of", "life", "according", "to", "the", "national", "recommendations", "History", "of", "or", "intercurrent", "diphtheria", ",", "tetanus", ",", "pertussis", ",", "hepatitis", "B", ",", "polio", ",", "and", "Haemophilus", "influenzae", "type", "b", "diseases", ".", "History", "of", "allergic", "disease", "or", "reactions", "likely", "to", "be", "exacerbated", "by", "any", "component", "of", "the", "vaccines", ".", "History", "of", "seizures", "(", "this", "criterion", "does", "not", "apply", "to", "subjects", "who", "have", "had", "a", "single", ",", "uncomplicated", "febrile", "convulsion", "in", "the", "past", ")", "or", "neurological", "disease", ".", "Acute", "disease", "at", "the", "time", "of", "enrolment", "Any", "confirmed", "or", "suspected", "immunosuppressive", "or", "immunodeficient", "condition", "based", "on", "medical", "history", "and", "physical", "A", "family", "history", "of", "congenital", "or", "hereditary", "immunodeficiency", ".", "Major", "congenital", "defects", "or", "serious", "chronic", "illness", ".", "Administration", "of", "immunoglobulins", "and/or", "any", "blood", "products", "since", "birth", "or", "planned", "administration", "during", "the", "active", "phase", "of", "the", "study", "." ]	[ "O", "O", "O", "O", "O", "B-Drug", "B-Drug", "O", "B-Drug", "O", "B-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mood", "I-Mood", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "B-Mood", "O", "O", "O", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "B-Drug", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Negation", "I-Negation", "I-Negation", "I-Negation", "B-Drug", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Temporal", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "O", "O", "O", "O", "O", "O", "B-Multiplier", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "B-Reference_point", "O", "B-Mood", "O", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O" ]
[ "Children", "(", "<", "18", "years", "old", ")", ".", "Women", "who", "are", "known", "to", "be", "pregnant", ".", "Any", "patient", "who", "has", "been", "previously", "randomized", "in", "the", "EvK", "Trial", ".", "Patients", "who", "require", "endotracheal", "intubation", "without", "sedative", "medication", ".", "For", "example", ",", "patients", "in", "full", "cardiac", "arrest", ".", "Patients", "with", "a", "known", "allergy", "to", "ketamine", "or", "etomidate", ".", "Any", "individual", "wearing", "a", "MedAlert", "bracelet", "indicating", "that", "he/she", "has", "formally", "opted", "out", "of", "the", "EvK", "Trial", "." ]	[ "B-Person", "O", "B-Value", "I-Value", "I-Value", "B-Person", "O", "O", "B-Person", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Temporal", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "B-Observation", "B-Procedure", "I-Procedure", "B-Negation", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition" ]
[ "1", ".", "Unable", "to", "ambulate", "at", "least", "150", "feet", "prior", "to", "stroke", ",", "or", "experienced", "intermittent", "claudication", "while", "walking", ";", "2.", "history", "of", "congestive", "heart", "failure", ",", "unstable", "cardiac", "arrhythmias", ",", "hypertrophic", "cardiomyopathy", ",", "severe", "aortic", "stenosis", ",", "angina", "or", "dyspnea", "at", "rest", "or", "during", "ADL", "'s", ";", "3", ".", "History", "of", "oxygen", "dependence", ";", "4", ".", "Preexisting", "neurological", "disorders", ",", "dementia", "or", "previous", "stroke", ";", "5", ".", "History", "of", "major", "head", "trauma", ";", "6", ".", "Legal", "blindness", "or", "severe", "visual", "impairment", ";", "7.", "history", "of", "psychosis", "or", "other", "Axis", "I", "disorder", "that", "is", "primary", ";", "8", ".", "Life", "expectancy", "<", "1", "yr.", ";", "9", ".", "Severe", "arthritis", "or", "other", "problems", "that", "limit", "passive", "range", "of", "motion", ";", "10", ".", "History", "of", "DVT", "or", "pulmonary", "embolism", "within", "6", "months", ";", "11", ".", "Uncontrolled", "diabetes", "with", "recent", "weight", "loss", ",", "diabetic", "coma", ",", "or", "frequent", "insulin", "reactions", ";", "12", ".", "Severe", "hypertension", "with", "systolic", ">", "200", "mmHg", "and", "diastolic", ">", "110", "mmHg", "at", "rest", ";", "13.", "attempt", "of", "suicide", "in", "the", "last", "2", "years", "or", "at", "suicidal", "risk", "assessed", "by", "SCID", "interview", ";", "14", ".", "Previous", "or", "current", "enrollment", "in", "a", "clinical", "trial", "to", "enhance", "motor", "recovery", ";", "15", ")", "currently", "exercising", "≥", "2", "times", "per", "week", "(", "≥20", "minutes", ")", ";", "16", ")", "Presence", "of", "non-MR", "compatible", "implants", ",", "pregnancy", "or", "severe", "claustrophobia", "." ]	[ "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Temporal", "O", "B-Reference_point", "O", "O", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "O", "B-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Temporal", "B-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Parsing_Error", "B-Temporal", "O", "B-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "O", "O", "B-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Qualifier", "B-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Multiplier", "B-Condition", "I-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Parsing_Error", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Parsing_Error", "I-Parsing_Error", "O", "O", "B-Device", "I-Device", "I-Device", "O", "B-Condition", "O", "B-Qualifier", "B-Condition", "O" ]
[ "Diagnosis", "of", "emphysema", "confirmed", "by", "CT", "scan", ".", "If", "a", "report", "of", "past", "CT", "scan", "is", "not", "available", "at", "site", "documenting", "then", "a", "CT", "scan", "is", "to", "be", "performed", "at", "screening", "Male", "or", "female", "patients", "at", "least", "18", "years", "of", "age", ".", "Able", "and", "willing", "to", "sign", "an", "informed", "consent", ".", "Patient", "with", "record", "of", "congenital", "AAT", "deficiency", "of", "phenotype", "PiZZ", "(", "homozygote", ")", "or", "other", "rare", "phenotypes", "related", "to", "AAT", "deficiency", "and", "with", "AAT", "serum", "level", "≤", "11", "micromole", ".", "For", "patients", "receiving", "IV", "AAT", "augmentation", "therapy", "the", "serum", "AAT", "level", "threshold", "does", "not", "apply", ".", "FEV1/SVC", "<", "70", "%", "of", "predicted", "value", "post", "bronchodilator", "(", "SVC", "is", "slow", "VC", ")", "and", "FEV1", "<", "80", "%", "of", "predicted", "value", "post-bronchodilator", "History", "of", "at", "least", "two", "moderate", "or", "severe", "exacerbations", "that", "required", "change", "in", "treatment", "(", "antibiotics", ",", "systemic", "steroids", ",", "hospitalization", ")", "in", "the", "last", "18", "months", "prior", "to", "date", "of", "screening", ",", "with", "at", "least", "one", "of", "these", "occurring", "within", "the", "last", "12", "months", "prior", "to", "screening", ".", "Ability", "to", "comply", "with", "completion", "of", "electronic", "diary", ".", "Ability", "to", "self-administer", "inhaled", "AAT", ".", "No", "significant", "abnormalities", "in", "serum", "hematology", ",", "serum", "chemistry", "and", "serum", "inflammatory", "/", "immunogenic", "markers", "according", "to", "the", "Principal", "Investigator", "'s", "judgment", ",", "taking", "into", "considerations", "the", "potential", "effects", "of", "the", "AAT", "deficiency", ".", "No", "significant", "abnormalities", "in", "urinalysis", "according", "to", "the", "Principal", "Investigator", "'s", "judgment", ",", "taking", "into", "considerations", "the", "potential", "effects", "of", "the", "AAT", "deficiency", ".", "No", "significant", "abnormalities", "in", "ECG", "per", "investigator", "judgment", ".", "Negative", "for", "HBsAg", "and", "for", "antibodies", "to", "HCV", ",", "HIV-1", ".", "AAT", "deficient", "patients", "who", "are", "either", "naïve", "(", "not", "receiving", "IV", "augmentation", "therapy", ")", "or", "AAT", "deficient", "patients", "(", "receiving", "IV", "augmentation", "therapy", ")", ",", "if", "they", "have", "been", "stable", "on", "regular", "therapy", "for", "at", "least", "3", "months", "prior", "to", "the", "screening", "visit", "and", "are", "willing", "to", "continue", "the", "same", "regime", "throughout", "this", "trial", ".", "Note", "that", "only", "sites", "in", "Germany", "can", "recruit", "patients", "who", "are", "currently", "being", "treated", "with", "IV", "AAT.Patients", "who", "stopped", "IV", "augmentation", "treatment", "6", "months", "prior", "to", "screening", "date", "and", "will", "not", "re-start", "this", "treatment", "for", "the", "course", "of", "the", "study", "will", "be", "considered", "Naïve", ".", "Non-pregnant", ",", "non-lactating", "female", "patients", ",", "whose", "screening", "pregnancy", "test", "is", "negative", "and", "who", "are", "using", "contraceptive", "methods", "deemed", "reliable", "by", "the", "investigator", ",", "or", "who", "are", "at", "least", "2", "years", "post-menopausal", "or", "surgically", "sterilized", "." ]	[ "O", "O", "B-Condition", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "B-Temporal", "B-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Temporal", "B-Reference_point", "B-Person", "O", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Context_Error", "I-Context_Error", "I-Context_Error", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "B-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Reference_point", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Qualifier", "O", "B-Qualifier", "B-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "B-Procedure", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "O", "B-Post-eligibility", "I-Post-eligibility", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "B-Observation", "I-Observation", "I-Observation", "I-Post-eligibility", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Subjective_judgement", "B-Qualifier", "B-Condition", "I-Condition", "B-Procedure", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Value", "O", "B-Measurement", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "B-Negation", "I-Negation", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "B-Qualifier", "O", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "O", "O", "O", "B-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "B-Person", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "O", "O", "B-Device", "I-Device", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "O", "B-Condition", "I-Condition", "O" ]
[ "Patients", "with", "craniotomy", "for", "supratentorial", "tumors", "under", "general", "anesthesia", "American", "Society", "of", "Anaesthesiologists", "(", "ASA", ")", "2", "and", "stable", "ASA", "3", "patients", "Elective", "surgery", "Patients", "with", "Glasgow", "Coma", "Scale", "(", "GCS", ")", "15/15" ]	[ "O", "O", "B-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Qualifier", "B-Measurement", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "B-Value" ]
[ "Patients", "suspected", "to", "have", "vitamin", "B12", "deficiency", "defined", "as", "a", "plasma", "vitamin", "B12", "below", "the", "reference", "interval", "(", "<", "200", "pmol/L", ")", "." ]	[ "O", "B-Mood", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O" ]
[ "Patients", "presenting", "for", "abdominal", "myomectomy", "with", "documented", "uterine", "fibroids", "on", "pelvic", "imaging", "(", "pelvic", "ultrasound", "or", "MRI", ")", "within", "in", "last", "12", "months", "Age", "=", "18", "years", "and", "=", "50", "years", "Pre-operative", "hemoglobin", ">", "8", "g/dl", "Willing", "to", "have", "buccal", "administration", "of", "misoprostol", "or", "a", "placebo", "at", "least", "one", "hour", "pre-procedure", ".", "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", ".", "Admissible", "medical/surgical", "history", "Can", "be", "previously", "treated", "with", "Depo-Lupron", ",", "Depo-Provera", ",", "or", "Oral", "Contraceptive", "pills", "Intraoperative", "use", "of", "vasopressin", "and", "uterine", "tourniquet", "is", "permissible", "Can", "have", "had", "prior", "Cesarean", "delivery" ]	[ "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Reference_point", "B-Measurement", "I-Measurement", "O", "B-Value", "B-Mood", "I-Mood", "I-Mood", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "O", "B-Temporal", "B-Procedure", "I-Procedure", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable" ]
[ "Men", "or", "women", "aged", "18-60", "years", ".", "Primary", "psychiatric", "diagnosis", "of", "Major", "Depressive", "Disorder", ",", "without", "psychotic", "features", ",", "confirmed", "via", "SCID-IV", "structured", "diagnostic", "interview", ".", "Screening", "Hamilton", "Depression", "Rating", "Scale", "(", "HAMD", ")", "=", "18", ";", "and", "Baseline", "HAMD", "=", "15", ".", "If", "the", "patient", "is", "a", "woman", "of", "child-bearing", "potential", ",", "she", "must", "agree", "to", "use", "an", "acceptable", "form", "of", "birth", "control", "for", "duration", "of", "study", "participation", ".", "Able", "to", "understand", "and", "provide", "informed", "consent", "for", "participation", "." ]	[ "B-Condition", "I-Condition", "B-Person", "B-Person", "B-Value", "I-Value", "I-Condition", "B-Qualifier", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "B-Qualifier", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]
[ "long-term", "use", "of", "analgesics", ",", "sedatives", "or", "non", "steroidal", "anti-inflammatory", "drugs", "history", ".", "known", "for", "dexmedetomidine", "or", "other", "drugs", "allergy", "in", "this", "study", ".", "can", "not", "communicate", ".", "preoperative", "systolic", "blood", "pressure", "<", "90", "mmHg", ",", "or", "the", "heart", "rate", "<", "50/min", "." ]	[ "B-Multiplier", "I-Multiplier", "O", "B-Drug", "O", "B-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "O", "O", "O", "B-Drug", "O", "B-Qualifier", "B-Drug", "B-Condition", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value" ]
[ "At", "least", "18", "years", "of", "age", "Signed", "informed", "consent", "African", "American", "race", "History", "of", "a", "solitary", "renal", "transplant", "Stable", "tacrolimus", "dose", "for", "at", "least", "2", "weeks", "prior", "to", "randomization" ]	[ "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Value", "I-Value", "B-Person", "I-Person", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "B-Qualifier", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point" ]
[ "NA" ]	[ "O" ]
[ "Patients", "receiving", "once", "daily", "dosing", "of", "methylprednisolone", "or", "prednisone", "in", "a", "dose", "of", "10", "mg/day", "or", "greater", "Hyperglycemic", "(", "Glucose", "level", ">", "126", "mg/dL", ")", "Diabetic", "and", "nondiabetic", "patients", "Expected", "duration", "of", "hospital", "stay", "and", "time", "on", "steroids", ">", "=", "3", "days", "Patient", "of", "appropriate", "caregiver", "able", "to", "give", "Informed", "Consent" ]	[ "O", "O", "B-Multiplier", "I-Multiplier", "O", "O", "B-Drug", "O", "B-Drug", "O", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "B-Condition", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]
[ "Men", "and", "women", "older", "than", "18", "years", ",", "scheduled", "consecutively", "to", "perform", "a", "coronary", "procedure", "in", "the", "department", "of", "hemodynamics", "of", "the", "National", "Institute", "of", "Cardiology", "``", "Ignacio", "Chavez", "''", ".", "Patients", "may", "have", "any", "of", "the", "following", "indications", "for", "cardiac", "catheterization", ":", "Thoracic", "pain", "under", "study", ".", "Stable", "chronic", "coronary", "disease", ".", "Acute", "myocardial", "infarction", "with", "ST", "segment", "elevation", ",", "not", "perfused", "(", "without", "timely", "reperfusion", "therapy", ")", "with", "less", "than", "4", "weeks", "of", "evolution", ".", "Acute", "myocardial", "infarction", "with", "ST-segment", "elevation", ",", "successful", "thrombolytic", "therapy", ",", "which", "will", "undergo", "drug-invasive", "therapy", ".", "Acute", "myocardial", "infarction", "without", "ST", "segment", "elevation", ".", "Unstable", "angina", ".", "Any", "acute", "coronary", "syndrome", ",", "to", "intervene", "non-infarct-related", "artery", ".", "Disease", "of", "any", "heart", "valve", ".", "Myocarditis", "or", "pericarditis", ".", "Dilated", "cardiomyopathy", ".", "Patients", "in", "renal", "or", "cardiac", "transplantation", "protocol", "for", "any", "etiology", ".", "Congenital", "heart", "disease", "that", "requires", "knowing", "the", "coronary", "anatomy", "prior", "to", "surgical", "correction", ".", "The", "planned", "procedure", "can", "be", "any", "of", "the", "following", ":", "For", "diagnostic", "purposes", "(", "coronary", "angiography", "only", ",", "left", "catheterization", ",", "left", "and", "right", "catheterization", ")", ".", "For", "therapeutic", "purposes", ":", "percutaneous", "coronary", "intervention", "(", "PCI", ")", ",", "with", "or", "without", "stent", "placement", ".", "A", "priori", "access", "must", "be", "right", "or", "left", "radial", "artery", ".", "Radial", "arterial", "pulse", "may", "be", "present", "or", "absent", "by", "palpation", ".", "Modified", "Allen", "or", "Barbeau", "test", "should", "be", "positive", "(", "presence", "of", "collateral", "palmar", "flow", ")", "." ]	[ "B-Person", "O", "B-Person", "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Visit", "I-Visit", "I-Visit", "O", "B-Visit", "I-Visit", "I-Visit", "I-Visit", "I-Visit", "O", "I-Visit", "I-Visit", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Negation", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Procedure", "B-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Procedure", "I-Procedure", "B-Qualifier", "I-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Qualifier", "I-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O", "B-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Value", "I-Value", "B-Value", "I-Value", "B-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition" ]
[ "NA" ]	[ "B-Non-query-able" ]
[ "Renal", "impairment", "Evidence", "or", "history", "of", "clinically", "significant", "allergic", "reactions", "to", "varenicline", "A", "cardiovascular", "event", "in", "the", "past", "month", "History", "of", "alcohol", "or", "drug", "dependence", "in", "the", "past", "year", "Major", "depressive", "disorder", "in", "the", "last", "year", "requiring", "treatment", "History", "of", "panic", "disorder", ",", "psychosis", ",", "bipolar", "disorder", ",", "or", "eating", "disorders", "Use", "of", "tobacco", "products", "other", "than", "cigarettes", "in", "past", "30", "days", "Use", "of", "pharmacotherapy", "in", "the", "month", "prior", "to", "enrollment", ",", "including", "prior", "use", "of", "varenicline", "Pregnant", ",", "contemplating", "getting", "pregnant", ",", "or", "breastfeeding", "Plans", "to", "move", "from", "Kansas", "City", "during", "the", "treatment", "and", "follow-up", "phase", "Another", "household", "member", "enrolled", "in", "the", "study", "Evidence", "of", "current", "severe", "major", "depressive", "disorder", "or", "suicidal", "ideation" ]	[ "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Temporal", "I-Temporal", "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Observation", "I-Observation", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition" ]
[ "indications", "to", "dual", "antiplatelet", "therapy", "other", "than", "atrial", "fibrillation", "or", "left", "atrial", "appendage", "occlusion", "at", "the", "time", "of", "enrollment", "or", "predicted", "appearance", "of", "such", "indications", "within", "the", "duration", "of", "the", "trial", "(", "eg", ".", "coronary", "artery", "disease", ")", "indications", "to", "anticoagulation", "at", "the", "time", "of", "enrollment", "or", "predicted", "appearance", "of", "such", "indications", "within", "the", "duration", "of", "the", "trial", "(", "eg", ".", "pulmonary", "embolism", ")", "known", "allergy", "to", "clopidogrel", "or", "acetylsalicylic", "acid", "precluding", "its", "administration", "as", "specified", "by", "the", "protocol", "any", "known", "inborn", "or", "acquired", "coagulation", "disorders", "poor", "tolerance", "of", "or", "technical", "difficulties", "with", "performing", "transesophageal", "echocardiography", "peridevice", "leak", ">", "5mm", "on", "transesophageal", "echocardiography", "study", "preceding", "enrollment", "left", "atrial", "thrombus", "on", "transesophageal", "echocardiography", "study", "performed", "after", "successful", "left", "atrial", "appendage", "closure", "but", "before", "enrollment", "life", "expectancy", "of", "less", "than", "18months", "participation", "in", "other", "clinical", "studies", "with", "experimental", "therapies", "at", "the", "time", "of", "enrollment", "and", "preceding", "3", "months", "chronic", "kidney", "disease", "stage", "IV", "and", "V", "women", "who", "are", "pregnant", "or", "breast", "feeding", ";", "women", "of", "childbearing", "potential", "who", "do", "not", "consent", "to", "apply", "at", "least", "to", "methods", "of", "contraception", ".", "This", "criterion", "does", "not", "apply", "to", "postmenopausal", "women" ]	[ "B-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Negation", "I-Negation", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Mood", "I-Mood", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Mood", "I-Mood", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Reference_point", "I-Reference_point", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Reference_point", "I-Reference_point", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Condition", "I-Condition", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations" ]
[ "Adult", "outpatients", "(", "18", "years", "or", "older", ")", "routinely", "referred", "for", "small", "bowel", "video", "capsule", "endoscopy", "(", "CE", ")" ]	[ "B-Person", "B-Visit", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Multiplier", "I-Multiplier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O" ]
[ "pathological", "obesity", "chronic", "diseases", "e.g", ".", "cerebral", "palsy", ",", "metabolic", "disease", ",", "etc", ".", "diseases", "of", "red", "blood", "cells", "on", "medication", "e.g", ".", "steroid", ",", "multivitamins", ",", "thiamine-containing", "vitamins", ",", "diuretic", "drugs", "hemodialysis", "or", "peritoneal", "dialysis", "bariatric", "surgery" ]	[ "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure" ]
[ "Major", "subjects", "of", "over", "40", "years", "(", "mean", "age", "of", "Meniere", "'s", "disease", "40", "to", "50", "years", ")", "Informed", "consent", "signed", "Medical", "examination", "performed", "prior", "to", "participation", "in", "research", "Patients", "without", "history", "of", "inner", "ear", "disease", "Recipient", "of", "a", "French", "social", "security", "scheme" ]	[ "O", "O", "O", "B-Value", "I-Value", "B-Person", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Negation", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]
[ "Caucasian", "patients", "affected", "by", "uncomplicated", ",", "essential", "hypertension", ",", "not", "well", "controlled", "by", "concomitant", "administration", "of", "ACE-I", "or", "ARBs", "and", "diuretics", "at", "the", "maximum", "dosage", "." ]	[ "B-Person", "O", "O", "O", "B-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "B-Drug", "O", "B-Drug", "O", "B-Drug", "O", "O", "B-Multiplier", "I-Multiplier", "O" ]
[ "Risk", "of", "severe", "alcohol", "withdrawal", "(", "e.g", ".", "history", "of", "seizures", "or", "delirium", "tremens", ")", "Current", "Moderate", "or", "Severe", "Substance", "Use", "Disorder", ",", "other", "than", "Alcohol", ",", "Nicotine", "or", "Caffeine", "Use", "Disorders", "Lifetime", "history", "of", "Bipolar", "Disorder", ",", "Schizophrenia", "or", "Schizoaffective", "Disorder", "Any", "current", "psychiatric", "disorder", ",", "other", "than", "Alcohol", "Use", "Disorder", ",", "that", ",", "in", "the", "judgment", "of", "the", "investigator", ",", "will", "require", "treatment", "that", "will", "interfere", "with", "study", "participation", ".", "Current", "severe", "depression", "(", "HAM-D", ">", "24", ")", "or", "anxiety", "(", "HAM-A", ">", "24", ")", "Significant", "suicide", "or", "violence", "risk", "Currently", "taking", "any", "psychotropic", "medications", "Legally", "mandated", "to", "participate", "in", "treatment", "History", "of", "prior", "treatment", "with", "disulfiram", "Sufficiently", "socially", "unstable", "as", "to", "preclude", "participation", "(", "e.g", ".", "homeless", ")", "Contraindications", "to", "disulfiram", "treatment", "(", "liver", "disease", ",", "kidney", "disease", ",", "cardiac", "disease", ",", "seizure", "disorder", ",", "hypothyroidism", ",", "diabetes", "mellitus", ",", "pregnancy", "or", "lactation", ",", "allergy", "to", "disulfiram", "or", "thiuran", "derivatives", ")", "Neurological", "or", "medical", "conditions", "that", "would", "interfere", "with", "MRI", "scanning", "(", "e.g", ".", "history", "of", "stroke", ",", "seizure", ",", "brain", "tumor", ",", "brain", "infection", ",", "traumatic", "brain", "injury", ",", "multiple", "sclerosis", ",", "dementia", ",", "metal", "device", "in", "body", ",", "pregnancy", ",", "claustrophobia", ",", "color", "blindness", ",", "severe", "hearing", "impairment", ",", "weight", ">", "300", "lbs.", ",", "wheelchair-bound", ")", "Currently", "taking", "medications", "containing", "alcohol", ",", "metronidazole", ",", "isoniazid", ",", "paraldehyde", ",", "phenytoin", ",", "warfarin", ",", "or", "theophylline", ".", "Significant", "alcohol", "withdrawal", "(", "CIWA", ">", "8", ")", "at", "screening", ",", "after", "confirming", "a", "blood", "alcohol", "level", "of", "zero", "." ]	[ "B-Mood", "I-Mood", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "B-Temporal", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Temporal", "B-Qualifier", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Condition", "I-Condition", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Temporal", "B-Qualifier", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Drug", "I-Drug", "I-Drug", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Drug", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Device", "I-Device", "I-Device", "I-Device", "I-Device", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "B-Drug", "B-Drug", "I-Drug", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Value", "O", "B-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement" ]
[ "History", "of", "allergic", "reaction", "to", "compounds", "of", "similar", "chemical", "or", "biologic", "composition", "to", "hCG", "receiving", "medication", "that", "could", "interfere", "with", "the", "study", "protocol", "objectives", "(", "hormonal", "contraceptives", ",", "androgens", ",", "prednisone", ",", "thyroid", "hormones", ",", "insulin", ")", "previous", "treatment", "with", "follicle", "stimulating", "hormone", "for", "assisted", "reproduction", "uncontrolled", "intercurrent", "illness", "Heart", "disease", "Severe", "cognitive", "decline", "Psychiatric", "desease", "HIV", "positive", "Hepatitis", "B", "or", "C", "infection" ]	[ "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Temporal", "B-Drug", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Temporal", "B-Procedure", "I-Procedure", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Procedure", "I-Procedure", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition" ]
[ "The", "diagnosis", "of", "chronic", "bronchitis", "The", "diagnosis", "of", "community-acquired", "pneumoniae", "FEV1", "value", "=", "30-80", "%", "The", "diagnosis", "of", "mild-severe", "acute", "exacerbation", "of", "chronic", "bronchitis", "(", "AECB", ")", "Oxygen", "saturation", "<", "90", "%" ]	[ "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "B-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value" ]
[ "Women", "(", "18-75", "years", ")", "with", "suspected", "UTI", "at", "least", "two", "symptoms", "of", "UTI", "(", "dysuria", ",", "urgency", "of", "micturition", ",", "frequency", ",", "lower", "abdominal", "pain", ")", "Written", "informed", "consent" ]	[ "B-Person", "O", "B-Value", "B-Person", "O", "O", "B-Qualifier", "B-Condition", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "Established", "Osteoarthritis", "(", "Kellgren-Lawrence", ">", "3", ")", "Minimum", "joint", "space", ">", "2", "mm", "as", "measured", "on", "AP", "radiograph", "Hip", "dysplasia", "(", "center", "edge", "angle", "<", "20°", "on", "AP", "radiograph", ")", "Patients", "with", "clinically", "significant", "cardiovascular", ",", "renal", ",", "hepatic", ",", "endocrine", "disease", ",", "cancer", "or", "diabetes", "Patients", "with", "ongoing", "infection", "including", "HIV", "and", "Hepatitis", "Patient", "with", "history", "of", "osteomyelitis/septic", "arthritis", "Anticoagulation", "therapy", "Patients", "who", "are", "pregnant", "or", "breast", "feeding", "Patients", "with", "systemic", ",", "rheumatic", "or", "inflammatory", "disease", "of", "the", "knee", "or", "chondrocalcinosis", ",", "hemochromatosis", ",", "inflammatory", "arthritis", ",", "arthropathy", "of", "the", "knee", "associated", "with", "juxta-articular", "Paget", "'s", "disease", "of", "the", "femur", "or", "tibia", ",", "hemophilic", "arthropathy", ",", "infectious", "arthritis", ",", "Charcot", "'s", "knee", "joint", ",", "villonodular", "synovitis", ",", "and", "synovial", "chondromatosis", "Patients", "taking", "immunosuppressant", "medication", "Patients", "with", "abnormal", "hematology", "or", "serum", "chemistry", "lab", "results", "Patients", "receiving", "injection", "to", "treatment", "knee", "within", "2", "months", "of", "study", "enrollment", "BMI", "greater", "than", "35", "or", "less", "than", "20" ]	[ "O", "B-Condition", "O", "B-Measurement", "B-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "O", "O", "B-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Parsing_Error", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O" ]
[ "Patients", "who", "had", "history", "of", "systemic", "antibiotic", "usage", "over", "the", "previous", "4", "months", "Patients", "who", "were", "pregnant", "Patients", "who", "had", "received", "non-surgical", "periodontal", "treatment", "within", "the", "past", "6", "months", "Patients", "who", "had", "received", "surgical", "periodontal", "treatment", "within", "the", "past", "12", "months", "Patients", "who", "were", "smokers", "Patients", "with", "a", "history", "of", "stroke", "or", "an", "acute", "cardiovascular", "event", "over", "the", "previous", "12", "months", "." ]	[ "O", "O", "O", "B-Temporal", "O", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]
[ "History", "of", "a", "primary", "sleep", "disorder", "other", "than", "RLS", "that", "may", "significantly", "affect", "the", "symptoms", "of", "RLS", ".", "Serum", "ferritin", "level", "<", "20", "ng/mL", "at", "screening", ".", "History", "of", "allergy", ",", "hypersensitivity", ",", "or", "intolerance", "to", "HORIZANT", "or", "any", "other", "gabapentin", "products", "(", "eg", ",", "Neurontin®", ",", "Gralise®", ")", ".", "Suffering", "from", "a", "movement", "disorder", "that", "could", "mimic", "or", "confound", "the", "accurate", "diagnosis", "of", "RLS", "(", "eg", ",", "Tourette", "'s", "syndrome", ",", "tic", "disorder", ",", "periodic", "limb", "movement", "disorder", "[", "PLMD", "]", ",", "sleep", "disorders", ")", ".", "Currently", "meet", "Diagnostic", "and", "Statistical", "Manual", "of", "Mental", "Disorders", "-", "Fifth", "Edition", "(", "DSM-5", ")", "criteria", "for", "substance", "use", "disorder", ",", "or", "history", "thereof", ",", "within", "12", "months", "before", "dosing", ".", "Current", "or", "past", "history", "of", "any", "significant", "psychiatric", "disorder", "including", ",", "but", "not", "limited", "to", ",", "depression", "(", "treatment", "with", "antidepressants", ")", ",", "bipolar", "disorder", ",", "or", "schizophrenia", ".", "Diagnosis", "of", "attention-deficit", "hyperactivity", "disorder", "(", "ADHD", ")", "is", "allowed", ",", "provided", "the", "patient", "is", "not", "receiving", "medication", "(", "s", ")", "known", "to", "affect", "the", "assessment", "of", "RLS", ".", "History", "of", "suicidal", "behavior", "or", "suicidal", "ideation", "as", "indicated", "by", "the", "C-SSRS", ",", "administered", "at", "screening", "(", "the", "questionnaire", "is", "provided", "in", "Appendix", "4", ")", ",", "and", "as", "per", "investigator", "'s", "judgment", ".", "History", "of", "seizure", "disorder", "or", "at", "increased", "risk", "for", "development", "of", "a", "seizure", "disorder", "including", ",", "but", "not", "limited", "to", ",", "complicated", "febrile", "seizure", "and", "history", "of", "significant", "head", "injury", ".", "Medical", "condition", "or", "disorder", "that", "would", "interfere", "with", "the", "action", ",", "absorption", ",", "distribution", ",", "metabolism", ",", "or", "excretion", "of", "gabapentin", "enacarbil", ",", "or", ",", "in", "the", "investigator", "'s", "judgment", "is", "considered", "to", "be", "clinically", "significant", "and", "may", "pose", "a", "safety", "concern", ",", "or", ",", "could", "interfere", "with", "the", "accurate", "assessment", "of", "safety", "or", "efficacy", ",", "or", "could", "potentially", "affect", "a", "patient", "'s", "safety", "or", "study", "outcome", ".", "Clinically", "significant", "abnormal", "laboratory", "result", "or", "physical", "examination", "finding", "not", "resolved", "by", "the", "time", "of", "baseline", "assessments", "." ]	[ "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Value", "I-Value", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Negation", "I-Negation", "I-Negation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]
[ "history", "of", "major", "systemic", "illness", ",", "including", "uncontrolled", "hypertension", ",", "diabetes", ",", "chronic", "renal", "insufficiency", ",", "autoimmune", "diseases", "or", "malignancies", "history", "of", "neurological", "disorders", "which", "might", "affect", "sensation", "such", "as", "previous", "stroke", "or", "peripheral", "neuropathy", "history", "of", "substance", "abuse", "(", "except", "painkillers", ")", "heavy", "smokers", "(", "with", "a", "daily", "consumption", ">", "20", "cigarettes", ")", "pregnancy", "or", "lactation", "any", "contraindication", "for", "magnetic", "resonance", "imaging", "(", "MRI", ")", "and", "any", "obvious", "infection", "or", "inflammation", "over", "a", "period", "of", "at", "least", "1", "month", "before", "the", "study", "." ]	[ "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "B-Drug", "I-Drug", "B-Qualifier", "B-Person", "I-Person", "I-Person", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "B-Observation", "I-Observation", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal" ]
[ "Healthy", "males", "between", "18", "and", "45", "years", "of", "age", "(", "inclusive", ")", ".", "Body", "mass", "index", "to", "be", "between", "18", "to", "30", "kg/m2", "(", "inclusive", ")", "as", "calculated", "by", "weight", "(", "Kg", ")", "/height", "(", "m2", ")", ".", "Subjects", "were", "to", "have", "no", "clinically", "significant", "abnormal", "findings", "on", "physical", "examination", ",", "ECG", ",", "medical", "history", ",", "or", "clinical", "laboratory", "results", "during", "screening", ".", "Subjects", "were", "to", ",", "in", "the", "opinion", "of", "the", "investigator", ",", "have", "no", "clinically", "significant", "abnormal", "findings", "of", "renal", "and", "hepatic", "function", "as", "determined", "by", "serum", "creatinine", ",", "total", "bilirubin", ",", "and", "transaminase", "levels", ".", "Subjects", "were", "to", "be", "non-users", "of", "tobacco", "products", "(", "minimum", "of", "6", "months", "prior", "to", "the", "start", "of", "the", "study", ")", ".", "Subjects", "were", "to", "have", "a", "negative", "screen", "for", "HIV", "I", "and", "II", ",", "HBsAg", ",", "and", "antibody", "to", "Hepatitis", "C", "virus", ".", "Subjects", "were", "to", "have", "a", "negative", "urine", "screen", "for", "alcohol", ",", "drugs", "of", "abuse", "(", "screening", "only", ")", ",", "and", "cotinine", ".", "Subjects", "were", "to", "use", "an", "appropriate", "barrier", "method", "of", "contraception", "(", "condom", "and", "spermicide", ")", "in", "addition", "to", "having", "their", "female", "partner", "use", "another", "form", "of", "barrier", "contraception", "(", "e.g.female", "condom", "or", "occlusive", "cap", "with", "spermicide", ")", "during", "the", "study", "and", "for", "3", "months", "following", "administration", "of", "the", "study", "drug", ".", "Subjects", "were", "able", "to", "comply", "with", "the", "protocol", "and", "the", "restrictions", "and", "assessments", "therein", ".", "Subjects", "were", "to", "give", "voluntary", "written", "informed", "consent", "to", "participate", "in", "the", "trial", "." ]	[ "B-Condition", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Negation", "B-Undefined_semantics", "I-Undefined_semantics", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "O", "B-Temporal", "I-Temporal", "O", "O", "B-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "B-Measurement", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O" ]
[ "Patients", "who", "undergo", "iliac", "crest", "bone", "graft", "harvesting", "as", "part", "of", "their", "surgery", "Preexisting", "neurological", "deficits", "or", "peripheral", "neuropathy", "in", "the", "distribution", "of", "the", "sciatic", "nerve", "Local", "infection", "Contraindication", "to", "regional", "anesthesia", "e.g", ".", "bleeding", "diathesis", ",", "coagulopathy", "Chronic", "pain", "disorders", "History", "of", "use", "of", "over", "30mg", "oxycodone", "or", "equivalent", "per", "day", "Allergy", "to", "local", "anesthetics", "History", "of", "significant", "psychiatric", "conditions", "that", "may", "affect", "patient", "assessment", "Pregnancy", "Inability", "to", "provide", "informed", "consent" ]	[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Multiplier", "B-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Condition", "I-Condition", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]
[ "Previously", "enrolled", "in", "this", "study", "(", "i.e", ".", "patient", "now", "at", "repeat", "encounter", ")", "Concomitant", "surgical", "procedure", "other", "than", "CABG", "Anticoagulant", "treatment", "after", "the", "operation", "(", "e.g", ".", "warfarin", ",", "direct", "thrombin", "inhibitors", "(", "dabigatran", ")", ",", "FXa", "inhibitors", "(", "rivaroxaban", ",", "apixaban", ",", "heparin", ",", "low-molecular", "weight", "heparin", ",", "fondaparinux", ")", "Discharge", "from", "the", "operating", "hospital", "to", "an", "ICU", "at", "another", "hospital", "Pregnancy", "or", "lactation", "Known", "intolerance", "or", "contraindication", "to", "ticagrelor", "or", "ASA", "Any", "disorder", "that", "may", "interfere", "with", "drug", "absorption", "Any", "condition", "other", "than", "coronary", "artery", "disease", "with", "a", "life", "expectancy", "<", "12", "months", "Known", "chronic", "liver", "disease", ",", "renal", "disease", "requiring", "dialysis", "or", "bleeding", "disorder", "Atrioventricular", "block", "II", "and", "III", "in", "patients", "without", "pacemaker", "Any", "other", "indication", "for", "dual", "antiplatelet", "therapy", ",", "i.e", ".", "recent", "stent", "implantation", "Debilitating", "stroke", "within", "90", "days", "before", "inclusion", "Previous", "intracranial", "bleeding", "Treatment", "with", "immunosuppressants", "(", "e.g", ".", "cyclosporine", "and", "tacrolimus", ")", "Treatment", "with", "strong", "CYP3A4-inhibitors", "(", "e.g", ".", "ketoconazole", ",", "clarithromycin", ",", "nefazodone", ",", "ritonavir", "or", "atazanavir", ")", "Any", "condition", "that", "in", "the", "opinion", "of", "the", "investigator", "may", "interfere", "with", "adherence", "to", "trial", "protocol" ]	[ "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Procedure", "I-Procedure", "B-Qualifier", "I-Qualifier", "B-Procedure", "B-Procedure", "I-Procedure", "B-Temporal", "B-Reference_point", "B-Procedure", "I-Procedure", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Observation", "I-Observation", "O", "B-Visit", "I-Visit", "I-Visit", "O", "O", "B-Visit", "B-Qualifier", "B-Visit", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Negation", "B-Device", "I-Device", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Procedure", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "B-Procedure", "I-Procedure", "I-Procedure", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "O", "B-Drug", "I-Drug", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]
[ "History", "of", "falls", "or", "dizziness", "at", "exit", "from", "bed", "in", "the", "morning", "(", "at", "least", "two", "incidents", "in", "the", "past", "year", ")", "At", "least", "20/200", "corrected", "visual", "acuity", "Stable", "health", "Normal", "hearing" ]	[ "O", "O", "B-Condition", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Condition", "B-Condition", "I-Condition" ]
[ "Overweight", "and", "obese", "PCOS", "patients", "with", "newly", "diagnosed", "IGR", ";", "PCOS", "diagnosis", "based", "on", "2003", "Rotterdam", "criteria", "Overweight", "/", "obesity", "diagnostic", "criteria", "according", "to", "WHO-WPR", "Impaired", "glucose", "regulation", "diagnostic", "criteria", "according", "to", "1998", "WHO", "diagnostic", "criteria", "." ]	[ "B-Condition", "O", "B-Condition", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier" ]
[ "Male", "and/or", "female", "patients", "from", "30-80", "years", "of", "age", "with", "a", "diagnosis", "of", "Type", "2", "diabetes", "(", "WHO", "criteria", ")", ".", "Incipient", "and", "established", "diabetic", "nephropathy", "(", "urinary", "albumin", "excretion", "≥", "100", "mg/day", "but", "≤", "2000", "mg/day", ")", ".", "Glomerular", "filtration", "rate", "(", "GFR", ")", "≥", "40", "ml/min", "(", "estimated", "using", "Modification", "of", "Diet", "in", "Renal", "Disease", "(", "MDRD", ")", "formula", ")", "in", "the", "last", "4", "months", ".", "Female", "patients", "must", "be", "postmenopausal", "or", "must", "have", "had", "a", "bilateral", "oophorectomy", "or", "must", "have", "been", "surgically", "sterilized", "or", "hysterectomized", "at", "least", "6", "months", "prior", "to", "screening", ".", "To", "be", "eligible", "patients", "must", "fulfill", "the", "following", "criteria", ":", "Patients", "on", "ongoing", "hypertensive", "therapy", "must", "have", "a", "blood", "pressure", "≥", "135/85", "mm", "Hg", "but", "lower", "than", "170/105", "mm", "Hg", "at", "baseline", "(", "Day", "-1", ")", "AND", "patients", "must", "be", "on", "stable", "antihypertensive", "medications", "for", "at", "least", "8", "weeks", "prior", "to", "baseline", "(", "Day", "-1", ")", ".", ";", "Newly", "diagnosed", "hypertensive", "patients", "must", "have", "a", "blood", "pressure", "≥", "135/85", "mm", "Hg", "but", "lower", "than", "170/105", "mm", "Hg", "at", "baseline", "(", "Day", "-1", ")", ".", "Patients", "must", "be", "on", "stable", "hypoglycemic", "medications", "for", "at", "least", "8", "weeks", "prior", "to", "Visit", "2", "(", "Day", "-1", ")", ".", "Patients", "must", "be", "willing", "and", "medically", "able", "to", "discontinue", "all", "Angiotensin-converting", "enzyme", "inhibitor", "(", "ACEI", ")", ",", "Angiotensin", "receptor", "blocker", "(", "ARB", ")", ",", "aldosterone", "receptor", "antagonist", "and", "potassium", "sparing", "diuretic", "medications", "for", "the", "duration", "of", "the", "study", ".", "Oral", "body", "temperature", "within", "the", "range", "35.0-37.5", "°C", "Able", "to", "provide", "written", "informed", "consent", "prior", "to", "study", "participation", ".", ".", "Able", "to", "communicate", "well", "with", "the", "investigator", "and", "comply", "with", "the", "requirements", "of", "the", "study", "." ]	[ "O", "O", "O", "O", "O", "B-Value", "I-Value", "B-Person", "I-Person", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Person", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Qualifier", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]
[ "A", "history", "of", "life-threatening", "asthma", "defined", "for", "this", "protocol", "as", "an", "asthma", "episode", "that", "required", "intubation", ",", "hypercapnea", "requiring", "non-invasive", "ventilatory", "support", ",", "respiratory", "arrest", ",", "hypoxic", "seizures", "or", "asthma-related", "syncopal", "episode", "(", "s", ")", ".", "Subjects", "with", "a", "history", "of", "asthma", "exacerbation", "requiring", "the", "use", "of", "systemic", "corticosteroids", "(", "tablets", ",", "suspension", ",", "or", "injection", ")", "for", "at", "least", "3", "days", "or", "a", "depot", "corticosteroid", "injection", "or", "emergency", "room", "attendance", "(", "within", "3", "months", ")", "or", "requiring", "hospitalization", "for", "asthma", "(", "within", "6", "months", ")", "prior", "to", "screening", ".", "Significant", ",", "non-reversible", "active", "pulmonary", "disease", "(", "e.g", ".", "cystic", "fibrosis", ",", "bronchiectasis", ",", "tuberculosis", ")", ".", "Culture-documented", "or", "suspected", "bacterial", "or", "viral", "infection", "of", "the", "upper", "or", "lower", "respiratory", "tract", ",", "sinus", "or", "middle", "ear", "that", "is", "not", "resolved", "within", "4", "weeks", "of", "Visit", "1", "and", "led", "to", "a", "change", "in", "asthma", "management", "or", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "is", "expected", "to", "affect", "the", "subject", "'s", "asthma", "status", "or", "the", "subject", "'s", "ability", "to", "participate", "in", "the", "study", ".", "Any", "fracture", "in", "the", "leg", "to", "be", "measured", "within", "6", "months", "prior", "to", "the", "screening", "visit", ".", "Any", "metabolic", "disorders", "or", "other", "diseases", "that", "may", "impact", "on", "normal", "growth", "patterns", ".", "No", "major", "surgery", "requiring", "general", "anaesthesia", "for", "at", "least", "3", "months", "prior", "to", "the", "screening", "visit", ".", "No", "febrile", "illnesses", "with", "temperature", ">", "39", "degree", "celsius", "for", "more", "than", "five", "consecutive", "days", "within", "the", "week", "preceding", "the", "Screening", "Visit", ".", "Any", "significant", "abnormality", "or", "medical", "condition", "identified", "at", "the", "screening", "medical", "assessment", "(", "including", "serious", "psychological", "disorder", ")", "that", "in", "the", "Investigator", "'s", "opinion", ",", "preclude", "entry", "into", "the", "study", "due", "to", "risk", "to", "the", "subject", "or", "that", "may", "interfere", "with", "the", "outcome", "of", "the", "study", ".", "Clinical", "visual", "evidence", "of", "candidiasis", "at", "Visit", "1", "(", "Screening", ")", ".", "Use", "of", "any", "of", "the", "prohibited", "medications", "listed", "in", "protocol", ".", "Strenuous", "physical", "exercise", "within", "3", "hours", "of", "Visit", "1", "(", "Screening", ")", "Drug", "allergies", ":", "Any", "adverse", "reaction", "including", "immediate", "or", "delayed", "hypersensitivity", "to", "any", "intranasal", ",", "inhaled", ",", "or", "systemic", "corticosteroid", "therapy", ".", "Known", "or", "suspected", "sensitivity", "to", "the", "constituents", "of", "the", "ELLIPTA", "Inhaler", "(", "i.e.", ",", "lactose", ",", "FF", ")", ".", "Milk", "Protein", "Allergy", ":", "History", "of", "severe", "milk", "protein", "allergy", ".", "The", "subject", "has", "participated", "in", "a", "clinical", "trial", "and", "has", "received", "an", "investigational", "product", "within", "the", "following", "time", "period", "prior", "to", "the", "first", "dosing", "day", "in", "the", "current", "study", ":", "30", "days", ",", "5", "half-lives", "or", "twice", "the", "duration", "of", "the", "biological", "effect", "of", "the", "investigational", "product", "(", "whichever", "is", "longer", ")", ".", "Exposure", "to", "more", "than", "4", "investigational", "medicinal", "products", "within", "12", "months", "prior", "to", "the", "first", "dosing", "day", ".", "Unable", "to", "use", "the", "ELLIPTA", "inhaler", "and", "peak", "flow", "meter", "correctly", ".", "An", "affiliation", "with", "the", "Investigator", "site", ":", "the", "parents/guardians", "or", "child", "is", "an", "immediate", "family", "member", "of", "the", "participating", "Investigator", ",", "sub-Investigator", ",", "study", "coordinator", ",", "or", "employee", "of", "the", "participating", "Investigator", ".", "The", "Parent", "or", "Guardian", "has", "a", "history", "of", "psychiatric", "disease", ",", "intellectual", "deficiency", ",", "substance", "abuse", "or", "other", "condition", "(", "e.g", ".", "inability", "to", "read", ",", "comprehend", "or", "write", ")", "which", "may", "affect", ":", "validity", "of", "consent", "to", "participate", "in", "the", "study", ";", "adequate", "supervision", "of", "the", "subject", "during", "the", "study", ";", "compliance", "of", "subject", "with", "study", "medication", "and", "study", "procedures", "(", "e.g", ".", "completion", "of", "daily", "diary", ",", "attending", "scheduled", "clinic", "visits", ")", ";", "subject", "safety", "and", "well-being", ".", "Children", "in", "care", ":", "Children", "who", "are", "wards", "of", "the", "government", "or", "state", "are", "not", "eligible", "for", "participation", "in", "this", "study", "." ]	[ "O", "B-Temporal", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "O", "B-Condition", "O", "B-Device", "I-Device", "I-Device", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Procedure", "O", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Subjective_judgement", "O", "B-Qualifier", "B-Temporal", "B-Undefined_semantics", "I-Undefined_semantics", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "B-Procedure", "O", "B-Observation", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Negation", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "B-Observation", "I-Observation", "B-Procedure", "I-Procedure", "O", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "O", "O", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "O", "B-Negation", "B-Undefined_semantics", "I-Undefined_semantics", "O", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Negation", "B-Condition", "I-Condition", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Subjective_judgement", "B-Undefined_semantics", "B-Condition", "I-Subjective_judgement", "B-Condition", "I-Condition", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Context_Error", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Drug", "O", "B-Drug", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "O", "B-Drug", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Drug", "I-Drug", "I-Subjective_judgement", "B-Device", "I-Device", "I-Device", "I-Subjective_judgement", "I-Subjective_judgement", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O" ]
[ "Capacity", "to", "provide", "informed", "consent", "before", "any", "trial-related", "activities", "Established", "T2DM", "(", "=3months", ")", "HbA1c", "=", "9", "%", "if", "on", "triple", "therapy", "or", "=", "10", "%", "on", "diet", "&", "exercise", "or", "monotherapy", "or", "dual", "therapy", "Current", "glucose", "lowering", "therapy", "either", "mono", ",", "dual", "or", "triple", "of", "any", "combination", "of", "metformin", ",", "sulphonylurea", ",", "DPP-IV", "inhibitor", ",", "GLP-1", "therapy", "or", "an", "SGLT2", "+/-", "diet", "and", "exercise", "Poorly", "managed", "diet", "controlled", "diabetes", "(", "with", "HbA1c", ">", "6.5", "%", ",", "not", "currently", "taking", "any", "glucose", "lowering", "therapy", ",", "meeting", "BMI", "inclusion", "range", ")", "Body", "mass", "index", ">", "30Kg/m2", "or", ">", "27.5", "Kg/m2", "(", "South", "Asian", ")", ",", "Diagnosis", "of", "T2DM", "before", "the", "age", "of", "60", "years", "of", "age", "Age", "=18", "and", "=", "65", "years" ]	[ "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Measurement", "B-Temporal", "I-Temporal", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "B-Observation", "I-Observation", "B-Observation", "I-Observation", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "B-Condition", "B-Value", "I-Value", "O", "B-Person", "O", "O", "O", "O", "O", "B-Person", "B-Value", "I-Value", "I-Value" ]
[ "Preoperative", "Hemoglobin", "<", "U+2266", ">", "11", "g/dl", "History", "of", "infection", "or", "intraarticular", "fracture", "of", "the", "affective", "hip", "Renal", "function", "deficiency", "(", "GFR", "<", "30", "ml/min/1.73m2", ")", "Elevated", "liver", "enzyme", "(", "aspartate", "transaminase", "(", "AST", ")", "/", "alanine", "transaminase", "(", "ALT", ")", "level", "are", "more", "than", "twice", "normal", "range", ")", ",", "history", "of", "liver", "cirrhosis", ",", "impaired", "liver", "function", "(", "elevated", "total", "bilirubin", "level", ")", "and", "coagulopathy", "(", "including", "long-term", "use", "anticoagulant", ")", "History", "of", "deep", "vein", "thrombosis", ",", "ischemic", "heart", "disease", "or", "stroke", "Contraindications", "of", "tranexamic", "acid", ",", "floseal", ",", "or", "rivaroxaban", "Allergy", "to", "tranexamic", "acid", ",", "floseal", ",", "rivaroxaban", ",", "or", "the", "excipients", "History", "of", "heparin-induced", "thrombocytopenia", "(", "HIT", ")", "Coagulopathy", "or", "bleeding", "tendency", "caused", "by", "organ", "dysfunction", ",", "such", "as", "cirrhosis", ",", "bone", "marrow", "suppression", "etc", ".", "Patient", "who", "have", "active", "bleeding", "disorder", ",", "such", "as", "intracranial", "hemorrhage", ",", "upper", "gastrointestinal", "bleeding", ",", "hematuria", ".", "Patients", "with", "known", "allergies", "to", "materials", "of", "bovine", "origin", "." ]	[ "B-Temporal", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Condition", "I-Condition", "B-Multiplier", "I-Multiplier", "B-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "I-Drug" ]
[ "Acute", "coronary", "syndrome", "(", "ACS", ")", "within", "3", "months", ".", "Under", "beta-blocker", "treatment", "for", "the", "last", "2", "weeks", ".", "Under", "other", "medicine", "treatment", "which", "may", "affect", "heart", "rate", ",", "like", "Non-dihydropyridine", "calcium", "channel", "blockers", "(", "NDHP-CCBs", ")", "or", "ivabradine", "for", "the", "last", "2", "weeks", ";", "Under", "Digoxin", "treatment", "[", "more", "than", "(", ">", ")", "0.125", "milligram", "(", "mg", ")", "]", ".", "Uncontrolled", "Diabetes", "[", "hemoglobin", "A1c", ",", "(", "HbA1c", ")", ">", "7.5", "%", "]", ".", "Severe", "or", "uncontrolled", "hypertension", "[", "resting", "Systolic", "Blood", "Pressure", "(", "SBP", ")", ">", "180", "millimeters", "of", "mercury", "(", "mmHg", ")", ",", "or", "resting", "Diastolic", "Blood", "Pressure", "(", "DBP", ")", ">", "110mmHg", "at", "screening", "period", "]", ".", "Severe", "hypotension", "[", "resting", "SBP", "less", "than", "(", "<", ")", "90mmHg", ",", "or", "resting", "DBP", "<", "50mmHg", "]", ".", "Resting", "heart", "rate", "<", "60", "beat", "per", "minute", "(", "bpm", ")", ".", "Any", "contradiction", "to", "Bisoprolol", "according", "to", "label", ",", "including", ":", "Acute", "heart", "failure", "or", "during", "episodes", "of", "heart", "failure", "decompensation", "requiring", "intravenous", "inotropic", "therapy", ".", "Cardiogenic", "shock", ".", "Atrioventricular", "block", "of", "second", "or", "third", "degree", "(", "without", "a", "pacemaker", ")", ".", "Sick", "sinus", "syndrome", ".", "Sinoatrial", "block", ".", "Slowed", "heart", "rate", ",", "causing", "symptoms", "(", "symptomatic", "bradycardia", ")", ",", "Decreased", "blood", "pressure", ",", "causing", "symptoms", "(", "symptomatic", "hypotension", ")", ",", "Severe", "bronchial", "asthma", "or", "severe", "chronic", "obstructive", "pulmonary", "disease", ".", "Sever", "forms", "of", "peripheral", "arterial", "occlusive", "disease", "and", "Raynaud", "'s", "syndrome", ".", "Untreated", "phaeochromocytoma", ".", "Metabolic", "acidosis", ".", "Hypersensitivity", "to", "bisoprolol", "or", "to", "any", "of", "the", "excipients", ".", "Severe", "Arrhythmia", "including", "atrial", "fibrillation", ",", "atrial", "flutter", ",", "ventricular", "fibrillation", ",", "ventricular", "flutter", "or", "ventricular", "tachycardia", ".", "Significant", "valvular", "heart", "disease", ",", "congenital", "heart", "disease", ",", "pulmonary", "heart", "disease", "or", "perinatal", "heart", "disease", ".", "Acute", "pulmonary", "edema", ".", "Severe", "hepatic", "dysfunction", ",", "defined", "as", ":", "Serum", "Alanine", "Aminotransferase", "(", "ALT", ")", ">", "triple", "the", "upper", "limit", "of", "the", "normal", "range", ";", "and/or", "Serum", "Aspartate", "Aminotransferase", "(", "AST", ")", ">", "triple", "the", "upper", "limit", "of", "the", "normal", "value", "range", "and/or", "Severe", "renal", "dysfunction", ",", "defined", "as", ":", "Serum", "creatinine", ">", "twice", "the", "upper", "limit", "of", "the", "normal", "range", "Chronic", "Kidney", "Disease", "(", "glomerular", "filtration", "rate", "<", "45", "Milliliter", "per", "minute", ")", ".", "Hyperthyroidism", "or", "hypothyroidism", ".", "Severe", "infectious", "disease", ",", "example", "(", "eg", ")", "Human", "Immunodeficiency", "Virus", "positive", "or", "active", "tuberculosis", ".", "Severe", "autoimmune", "disease", ",", "e.g", ".", "lupus", "erythematosus", ",", "multiple", "sclerosis", ".", "Severe", "respiratory", ",", "digestive", ",", "hematological", "disease", "(", "including", "Anemia", "of", "Hb", "<", "100", "gram", "per", "litre", ")", "or", "tumor", ".", "Known", "to", "be", "hypersensitivity", "to", "Bisoprolol", ",", "or", "any", "of", "the", "excipient", ".", "Substance", "or", "alcohol", "abuse", ".", "Received", "heart", "transplantation", "or", "pacemaker", "implantation", ";", "revascularization", "treatment", "within", "3", "months", ";", "or", "plan", "to", "receive", "above", "treatment", "in", "6", "months", ".", "Currently", "undertaking", "other", "treatment", "that", "may", "affect", "the", "safety", "and/or", "efficacy", "evaluation", ",", "e.g", ".", "beta", "receptors", "agonists", ",", "et", "cetera", ".", "No", "legal", "ability", "or", "legal", "ability", "is", "limited", ".", "Subjects", "unlikely", "to", "cooperate", "in", "the", "study", "or", "with", "inability", "or", "unwillingness", "to", "give", "informed", "consent", ".", "Child-bearing", "period", "women", "without", "effective", "contraceptive", "measures", ",", "pregnancy", "and", "lactation", ".", "Participation", "in", "another", "clinical", "trial", "within", "the", "past", "90", "days", ".", "Other", "significant", "condition", "that", "in", "the", "Investigator", "'s", "opinion", "would", "exclude", "the", "subject", "from", "the", "trial", "." ]	[ "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "B-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Drug", "I-Drug", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "B-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "B-Value", "I-Value", "B-Reference_point", "I-Reference_point", "I-Temporal", "I-Temporal", "B-Qualifier", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Value", "I-Value", "I-Value", "B-Qualifier", "I-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Negation", "O", "B-Device", "I-Device", "I-Device", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Qualifier", "I-Qualifier", "O", "B-Drug", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Non-query-able", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Qualifier", "I-Qualifier", "B-Drug", "I-Drug", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Temporal", "I-Temporal", "O", "B-Mood", "I-Mood", "O", "O", "O", "B-Temporal", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "Patients", "will", "not", "be", "included", "if", "they", "have", "reached", "a", "stable", "dose", "of", "warfarin", ",", "liver", "dysfunction", ",", "alcoholism", ",", "use", "of", "another", "anticoagulant", ",", "use", "of", "chemotherapy", ",", "or", "if", "they", "do", "not", "meet", "the", "inclusion", "criteria" ]	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multiplier", "I-Multiplier", "O", "B-Drug", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Qualifier", "B-Drug", "O", "O", "O", "B-Procedure", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "Has", "previously", "received", "Dapsone", "therapy", ".", "The", "subject", "or", "any", "of", "their", "healthcare", "providers", "is", "aware", "of", "the", "subjects", "HLA", "type", ".", "Has", "been", "diagnosed", "with", "Glucose-6-phosphate", "dehydrogenase", "deficiency", "or", "methemoglobin", "reductase", "deficiency", "Satisfies", "any", "contraindications", "or", "restrictions", "to", "Dapsone", "therapy", "as", "listed", "in", "the", "product", "labels", ".", "Current", "severe", "illness", ",", "including", "heart", ",", "liver", "and", "renal", "failure", ",", "major", "organ", "allograft", ",", "malignancy", "requiring", "parenteral", "chemotherapy", "that", "can", "not", "be", "discontinued", "for", "the", "duration", "of", "the", "trial", ",", "or", "any", "other", "conditions", "which", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "would", "make", "the", "patient", "unsuitable", "for", "the", "study", ".", "Any", "laboratory", "abnormality", "at", "Screening", "which", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "should", "preclude", "the", "subject", "'s", "participation", "in", "the", "study", "[", "alanine", "aminotransferase", "(", "ALT", ")", ",", "glutamic", "oxaloacetic", "transaminase", "(", "ALT", ")", ",", "et", "al", ")", ".", "Pregnant", "women", "or", "women", "who", "are", "breastfeeding", ".", "Subject", "is", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "unable", "to", "complete", "the", "6", "week", "Observation", "period", "and", "the", "EPT", "assessments", "as", "required", ".", "A", "positive", "result", "for", "HLA-B", "*", "1301", "in", "those", "subjects", "randomised", "to", "the", "genetic", "screening", "arm", "." ]	[ "O", "O", "O", "B-Drug", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Value", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "Age", ":", "from", "20", "to", "90", "y/o", ".", "HBsAg-positive", "for", "more", "than", "6", "months", "and", "HBV", "DNA", "<", "2000", "IU/ml", "(", "Subgroup", "1", ")", "or", "HBsAg-negative", "but", "anti-HBc", "positive", "with", "HBV", "DNA", "<", "2000", "IU/ml", "(", "Subgroup", "2", ")", ".", "Inflammatory", "arthritis", "patients", "who", "plan", "to", "treat", "with", "biological", "agents", ",", "including", "Humira", "or", "Enbrel", "or", "Simponi", "or", "Orencia", "or", "Mabthera", "or", "Actemra", ";", "as", "first", "line", "biologic", "treatment", "is", "indicated", "." ]	[ "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "O", "O", "B-Value", "O", "B-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O" ]
[ "using", "daily", "medication", "for", "chronic", "condition", "acute", "narrow", "angle", "glaucoma", "previous", "adverse", "experience", "with", "study", "drugs", "experiences", "motion", "sickness", "in", "response", "to", "driving", "simulator", "BMI", ">", "30", "women", "who", "are", "pregnant", ",", "lactating", ",", "or", "planning", "on", "becoming", "pregnant", "regular", "use", "of", "tobacco", "products", "current", "substance", "use", "disorder", "clinically", "significant", "ECG", "current", "ongoing", "psychiatric", "disorder" ]	[ "O", "B-Multiplier", "B-Drug", "O", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Mood", "I-Mood", "I-Mood", "B-Condition", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Procedure", "B-Temporal", "B-Condition", "I-Condition" ]
[ "Contraindications", "for", "spinal", "anesthesia", "(", "like", "bleeding", "diathesis", "or", "regional", "infection", "at", "site", "of", "neuroaxial", "block", ")", "Known", "allergy", "to", "Granisetron", "or", "local", "anaesthetic", "(", "heavy", "bupivacaine", ",", "Marcaine", "Spinal", "0.5", "%", "Heavy", ",", "5mg/ml", ",", "AstraZeneca", "ampule", ")", "Pregnancy", "induced", "hypertension", "Congenital", "or", "rheumatic", "heart", "diseases", "Antepartum", "haemorrhage", "Fetal", "destress", "or", "gestational", "age", "<", "36", "week" ]	[ "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Condition", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value" ]
[ "elective", "procedure", "weight", "over", "40", "kg", "American", "Society", "of", "Anesthesiology", "class", "I-III", "first", "upper", "GI", "endoscopy", "procedure", "finnish", "or/and", "swedish", "speaking" ]	[ "B-Procedure", "I-Procedure", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Multiplier", "B-Qualifier", "I-Qualifier", "B-Procedure", "I-Procedure", "B-Observation", "I-Observation", "B-Observation", "I-Observation" ]
[ "Smoker", "or", "former", "smoker", ".", "Presence", "of", "dental", "prostheses", ".", "Presence", "of", "orthodontic", "devices", ".", "Antibiotic", "treatment", "or", "routine", "use", "of", "oral", "antiseptics", "in", "the", "previous", "3", "months", ".", "Presence", "of", "any", "systemic", "disease", "that", "could", "alter", "the", "production", "or", "composition", "of", "saliva", "." ]	[ "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Device", "I-Device", "I-Device", "O", "O", "B-Device", "I-Device", "I-Device", "B-Drug", "I-Drug", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier" ]
[ "ASA", "I-IV", "Age", "55", "or", "older", "Scheduled", "for", "operative", "repair", "of", "isolated", "intertrochanteric", "hip", "fracture" ]	[ "B-Line", "B-Value", "B-Line", "B-Value", "I-Value", "I-Value", "B-Line", "I-Line", "B-Procedure", "I-Procedure", "I-Line", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition" ]
[ "Currently", "pregnant", "or", "using", "a", "reliable", "contraception", "(", "e.g", ".", "injectables", ",", "intrauterine", "devices", ",", "implant", ",", "oral", "contraceptive", "pills", ")", "Desiring", "pregnancy", "in", "the", "next", "year", "History", "of", "tubal", "ligation", "or", "hysterectomy", "Contraindication", "to", "progestin-only", "contraceptives", "Unable", "to", "comprehend", "consent", "material", "because", "of", "language", "barrier", "or", "psychological", "difficulty" ]	[ "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "B-Non-query-able", "I-Non-query-able", "B-Qualifier", "B-Procedure", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "Advanced", "male", "factor", "infertility", ".", "Polycystic", "ovary", "syndrome", "(", "PCOS", ")", "as", "defined", "by", "the", "Rotterdam", "criteria", ".", "Endometriosis", ".", "Tubal", "disease", ".", "Uterine", "abnormalities", "or", "myoma", ".", "Previous", "uterine", "surgery", ".", "Metabolic", "or", "hormonal", "abnormalities", "." ]	[ "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition" ]
[ "Male", "or", "female", "patients", "=", "18", "and", "=", "85", "years", "of", "age", "Women", "of", "child", "bearing", "potential", "must", "test", "negative", "on", "standard", "pregnancy", "test", "(", "urine", "or", "serum", ")", "Patients", "with", "body", "weight", "=", "55", "kg", "and", "=", "140", "kg", "and", "body", "mass", "index", "(", "BMI", ")", "=", "18", "kg/m2", "Patients", "diagnosed", "severe", "sepsis", "/", "septic", "shock", "at", "admission", "on", "Intensive", "Care", "Unit", "who", "can", "be", "enrolled", "within", "90", "min", "after", "admission", "OR", "patients", "diagnosed", "severe", "sepsis", "/", "septic", "shock", "during", "Intensive", "Care", "Unit", "stay", "who", "can", "be", "enrolled", "within", "90", "min", "after", "diagnosis", "Patients", "where", "antibiotic", "therapy", "has", "already", "been", "started", "(", "prior", "to", "randomization", ")", "Patient", "who", "are", "fluid", "responsive", ".", "Fluid", "responsiveness", "is", "defined", "as", "increase", "of", ">", "10", "%", "in", "mean", "arterial", "pressure", "(", "MAP", ")", "after", "passive", "leg", "raising", "(", "PLR", ")", "Signed", "informed", "consent", "by", "patient", ",", "legal", "representative", "or", "authorized", "person", "or", "deferred", "consent" ]	[ "B-Person", "O", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Person", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]
[ "Subjects", "aged", "18", "years", "or", "older", ",", "at", "the", "time", "of", "signing", "the", "informed", "consent", ".", "Subjects", "with", "documented", "physician", "diagnosis", "of", "asthma", "as", "their", "primary", "respiratory", "disease", ".", "ACT", "score", "<", "20", "at", "screening", "visit", ".", "Non-smokers", "(", "never", "smoked", "or", "not", "smoking", "for", ">", "6", "months", "with", "<", "10", "pack", "years", "history", "(", "Pack", "years", "=", "[", "cigarettes", "per", "day", "smoked/20", "]", "multiplied", "by", "number", "of", "years", "smoked", ")", ".", "Male", "or", "female", "subjects", "will", "be", "included", ".", "A", "female", "subject", "is", "eligible", "to", "participate", "if", "she", "is", "not", "pregnant", ",", "not", "breastfeeding", ",", "and", "at", "least", "one", "of", "the", "following", "conditions", "applies", ":", "(", "i", ")", "Not", "a", "woman", "of", "childbearing", "potential", "(", "WOCBP", ")", ".", "(", "ii", ")", "A", "WOCBP", "who", "agrees", "to", "follow", "the", "contraceptive", "guidance", "during", "the", "treatment", "period", "and", "for", "at", "least", "5", "days", "]", "after", "the", "last", "dose", "of", "study", "treatment", ".", "Capable", "of", "giving", "signed", "informed", "consent", "which", "includes", "compliance", "with", "the", "requirements", "and", "restrictions", "listed", "in", "the", "consent", "form", "and", "protocol", ".", "Subject", "understands", "and", "is", "willing", ",", "able", ",", "and", "likely", "to", "comply", "with", "study", "procedures", "and", "restrictions", ".", "Subject", "must", "be", "able", "to", "read", "in", "a", "language", "supported", "by", "the", "smart", "phone", "app", "in", "their", "region", ".", "Subject", "must", "have", "been", "on", "maintenance", "therapy", "(", "Fixed", "dose", "combination", "ICS/LABA", ")", "for", "3", "months", ",", "can", "not", "have", "changed", "dose", "in", "the", "month", "prior", "to", "screening", "and", "be", "able", "to", "change", "to", "an", "equivalent", "dose", "of", "RELVAR/BREO", "for", "the", "duration", "of", "the", "study", ".", "Other", "background", "asthma", "medication", "such", "as", "anti-leukotrienes", "and", "oral", "corticosteroids", "are", "permitted", "provided", "the", "dose", "has", "been", "stable", "for", "1", "month", "prior", "to", "screening", ".", "Subject", "must", "be", "able", "to", "change", "to", "Salbutamol/Albuterol", "MDI", "rescue", "for", "the", "duration", "of", "the", "study", "and", "judged", "capable", "of", "withholding", "albuterol/salbutamol", "for", "at", "least", "6", "hours", "prior", "to", "study", "visits", ".", "Subject", "must", "have", "their", "own", "Android", "or", "iPhone", "operating", "system", "(", "IOS", ")", "smart", "phone", "and", "a", "data", "package", "suitable", "for", "the", "installation", "and", "running", "of", "the", "app", "and", "sending", "and", "receiving", "data", ".", "Data", "used", "by", "the", "CIS", "is", "approximately", "1", "megabyte", "(", "MB", ")", "per", "month", "as", "a", "maximum", ";", "this", "is", "less", "data", "than", "a", "1", "minute", "video", "streamed", "from", "YouTube", "(", "2MB", ")", ".", "Subjects", "must", "be", "willing", "and", "able", "to", "download", "the", "app", "on", "their", "personal", "smart", "phone", "and", "keep", "it", "turned", "on", "for", "the", "duration", "of", "the", "study", ".", "This", "will", "also", "require", "Bluetooth", "to", "be", "turned", "on", "for", "duration", "of", "the", "study", ".", "Subjects", "will", "also", "have", "to", "turn", "on", "mobile", "data", "for", "the", "app", "for", "the", "duration", "of", "study", ";", "unless", "travelling", "and", "when", "extra", "data", "roaming", "costs", "could", "be", "incurred", ".", "ACT", "score", "<", "20", "at", "randomization", "visit", "(", "visit", "2", ")", "." ]	[ "O", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Temporal", "I-Temporal", "I-Temporal", "B-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "B-Person", "B-Person", "I-Person", "O", "O", "O", "O", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Multiplier", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Negation", "I-Negation", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "B-Mood", "I-Mood", "B-Drug", "B-Drug", "B-Procedure", "I-Procedure", "I-Procedure", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Measurement", "I-Measurement", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal" ]
[ "1", ")", "preoperative", "diagnosis", "of", "delirium", "or", "dementia", ";", "2", ")", "MMSE", "score", "of", "=", "20", "out", "of", "30", "on", "preoperative", "testing", "(", "more", "than", "mild", "cognitive", "impairment", ")", "or", "delirium", "on", "preoperative", "CAM", "testing", ";", "3", ")", "language", "barriers", "that", "would", "preclude", "testing", ";", "4", ")", "preoperative", "steroid", "use", "within", "3", "days", "of", "surgery", ";", "or", "5", ")", "anticipation", "of", "postoperative", "intubation", "." ]	[ "B-Line", "I-Line", "B-Temporal", "I-Line", "I-Line", "B-Condition", "I-Line", "B-Condition", "I-Line", "B-Line", "I-Line", "B-Measurement", "I-Measurement", "I-Line", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Line", "B-Temporal", "I-Line", "I-Line", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Line", "I-Line", "B-Condition", "I-Line", "B-Temporal", "B-Procedure", "I-Procedure", "I-Line", "B-Line", "I-Line", "B-Observation", "I-Observation", "I-Line", "I-Line", "I-Line", "I-Line", "I-Line", "B-Line", "I-Line", "B-Temporal", "B-Drug", "I-Line", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Line", "O", "B-Line", "I-Line", "B-Mood", "I-Line", "B-Temporal", "B-Procedure", "I-Line" ]
[ "Patients", "must", "be", "more", "than", "18", "years", "of", "age", "and", "referred", "for", "coronary", "angiography" ]	[ "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure" ]
[ "latex", "allergy", "non-reassuring", "fetal", "status", "HIV", "active", "herpes", "outbreak", "Prior", "uterine", "scar", "Contraindication", "to", "prostaglandins", "according", "to", "current", "Parkland", "protocol", "Contraindication", "to", "vaginal", "delivery" ]	[ "B-Drug", "B-Condition", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "O", "O", "B-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure" ]
[ "Systemic", "therapy", "or", "radiotherapy", "within", "4", "weeks", "prior", "to", "Day", "1", "Prior", "therapy", "with", "agents", "targeting", "the", "DR5", "apoptosis", "pathway", "Major", "surgical", "procedure", ",", "open", "biopsy", ",", "or", "significant", "traumatic", "injury", "within", "4", "weeks", "prior", "to", "Day", "1", ",", "or", "anticipation", "of", "need", "for", "major", "surgical", "procedure", "during", "the", "course", "of", "the", "study", "Other", "invasive", "malignancies", "within", "5", "years", "prior", "to", "Day", "1", "Known", "active", "brain", "metastases", "Uncontrolled", "intercurrent", "illness", ",", "including", "but", "not", "limited", "to", "ongoing", "or", "active", "infection", "requiring", "parenteral", "antibiotics", "at", "enrollment", "Clinically", "significant", ",", "symptomatic", "cardiovascular", "disease", ",", "New", "York", "Heart", "Association", "(", "NYHA", ")", "Grade", "II", "or", "greater", "congestive", "heart", "failure", ",", "serious", "cardiac", "arrhythmia", ",", "Grade", "II", "or", "greater", "peripheral", "vascular", "disease", ",", "or", "history", "of", "major", "heart", "surgery", "within", "6", "months", "of", "Day", "1", ",", "or", "any", "situation", "that", "would", "likely", "limit", "compliance", "with", "study", "requirements", "Known", "to", "be", "positive", "for", "hepatitis", "C", "or", "hepatitis", "B", "surface", "antigen", "History", "of", "other", "disease", ",", "metabolic", "dysfunction", ",", "physical", "examination", "finding", ",", "or", "clinical", "laboratory", "finding", "giving", "reasonable", "suspicion", "of", "a", "disease", "or", "condition", "that", "contraindicates", "use", "of", "an", "investigational", "drug", "or", "that", "might", "affect", "interpretation", "of", "the", "results", "of", "the", "study", "or", "render", "the", "patient", "at", "high", "risk", "for", "treatment", "complications", "Use", "of", "anticoagulation", "therapy", "Participation", "in", "clinical", "trials", "or", "undergoing", "other", "investigational", "procedures", "within", "30", "days", "prior", "to", "Day", "1", "Pregnancy", "or", "breast", "feeding", "Known", "sensitivity", "to", "any", "of", "the", "products", "administered", "during", "the", "study", "Any", "disorder", "that", "compromises", "the", "ability", "of", "the", "patient", "to", "give", "written", "informed", "consent", "and/or", "comply", "with", "study", "procedures" ]	[ "B-Procedure", "I-Procedure", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Temporal", "B-Procedure", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Qualifier", "B-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "B-Mood", "I-Mood", "I-Mood", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Qualifier", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "B-Temporal", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Temporal", "O", "B-Qualifier", "B-Condition", "O", "B-Drug", "I-Drug", "B-Temporal", "B-Reference_point", "B-Qualifier", "I-Qualifier", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Temporal", "I-Temporal", "B-Qualifier", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "B-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Temporal", "O", "B-Qualifier", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Mood", "I-Mood", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "B-Condition", "O", "B-Observation", "I-Observation", "O", "B-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "O", "B-Negation", "I-Negation", "I-Negation", "I-Negation", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure" ]
[ "Primary", "kidney", "transplant", "recipients", ",", "adults" ]	[ "B-Qualifier", "B-Procedure", "I-Procedure", "O", "O", "B-Person" ]
[ "pregnancy", ",", "patients", "under", "legal", "custody", ",", "patients", "without", "health", "insurance", ",", "patients", "included", "in", "another", "interventional", "clinical", "study", "involving", "infections", "or", "antibiotics", "and", "having", "the", "same", "primary", "parameter", ",", "moribund", "patients", ",", "situation", "in", "which", "the", "procalcitonin", "concentration", "could", "be", "increased", "without", "correlation", "to", "an", "infectious", "process", "(", "poly-traumatised", "patients", ",", "surgical", "interventions", "within", "the", "last", "4", "days", ",", "cardiorespiratory", "arrest", ",", "administration", "of", "anti-thymocyte", "globulin", ",", "immunodepressed", "patients", "(", "bone", "marrow", "transplant", "patients", ",", "patients", "with", "severe", "neutropenia", ")", ",", "patients", "with", "an", "absolute", "indication", "for", "administration", "of", "antibiotics", "at", "the", "moment", "of", "ICU", "admission", "(", "meningitis", ",", "pneumonia", ")", "or", "a", "chronic", "infection", "for", "which", "long-term", "antibiotic", "treatment", "is", "necessary", "(", "endocarditis", ",", "osteo-articular", "infections", ",", "mediastinitis", ",", "deep", "abscesses", ",", "pneumocystis", "infection", ",", "toxoplasmosis", ",", "tuberculosis", ")", "patients", "with", "haemodynamic", "instability", "of", "septic", "origin", "or", "a", "respiratory", "insufficiency", "(", "defined", "by", "a", "ratio", "Pa02/Fi02", "=", "200", "mmHg", "and", "PEP", "=", "5", "cmH2O", ")" ]	[ "B-Condition", "O", "O", "O", "B-Person", "I-Person", "I-Person", "O", "B-Negation", "B-Person", "I-Person", "I-Person", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "B-Visit", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement" ]
[ "eGFR", "<", "60", "T2DM", "patients", "on", "insulin", ",", "GLP-1", "RA", "or", "SGLT2", "treatment", "Major", "organ", "disease", "type", "1", "diabetes" ]	[ "B-Line", "B-Value", "I-Value", "B-Line", "I-Line", "I-Line", "B-Drug", "I-Line", "B-Drug", "B-Drug", "I-Line", "B-Drug", "I-Line", "B-Line", "I-Line", "I-Line", "B-Line", "I-Line", "I-Line" ]
[ "Probable", "or", "definite", "diagnosis", "of", "autoimmune", "hepatitis", "according", "to", "the", "International", "Autoimmune", "Hepatitis", "Study", "Group", "criteria", "First", "presentation", "of", "AIH", "requiring", "treatment", "according", "to", "the", "current", "EASL", "guidelines", "Age", "=", "18", "years", "Must", "provide", "informed", "consent", "and", "agree", "to", "comply", "with", "the", "trial", "protocol" ]	[ "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "B-Condition", "O", "B-Procedure", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Person", "I-Person", "B-Value", "I-Value", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]
[ ">", "=", "18", "years", "old", "the", "day", "of", "inclusion", "Pregnancy", "Positive", "HBs", "Ag", "Informed", "consent", "obtained", "with", "information", "sheet", "given", "and", "explained", "and", "the", "consent", "form", "signed", "by", "the", "participant", "of", "the", "project", "investigator", "at", "the", "latest", "the", "day", "of", "the", "inclusion" ]	[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "O", "O", "O", "B-Condition", "B-Value", "B-Measurement", "I-Measurement", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]
[ "Pregnancy", ",", "coagulopathy", ",", "allergy", "to", "bupivacaine", ",", "renal", "failure", ",", "hepatic", "insufficiency", ",", "and/or", "inappropriate", "candidate", "for", "usual", "therapy", "(", "specifically", ",", "if", "unable", "to", "receive", "the", "usual", "preoperative", "interscalene", "nerve", "block", ":", "preexisting", "nerve", "injury", "on", "side", "of", "surgery", ",", "refusal", "of", "nerve", "block", ",", "infection", "at", "site", "of", "nerve", "block", ")", "." ]	[ "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Drug", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Mood", "I-Mood", "I-Mood", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O" ]
[ "Able", "to", "give", "fully", "informed", "consent", "in", "writing", "Males", "or", "females", "aged", ">", "/=", "50", "years", "No", "significant", "disease", "or", "drug", "use", "Absence", "of", "any", "sign", "of", "dementia/cognitive", "impairment", "in", "neuropsychological", "examinationsPatients", "for", "brain", "imaging", ":", "Patient", "and", "designee", "capable", "of", "giving", "fully", "informed", "consent", "in", "writing", "Patient", "fulfils", "DSM-IV", "and", "NINCDS-ADRA", "criteria", "for", "probable", "Alzheimers", "disease" ]	[ "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Person", "O", "B-Person", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "B-Subjective_judgement", "B-Condition", "O", "B-Condition", "I-Condition", "B-Negation", "I-Negation", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Procedure", "B-Parsing_Error", "I-Parsing_Error", "I-Parsing_Error", "I-Parsing_Error", "I-Parsing_Error", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O", "B-Value", "B-Measurement", "O", "B-Measurement", "I-Measurement", "O", "B-Mood", "B-Condition", "I-Condition" ]
[ "Age", "=", "18", "years", "American", "Society", "of", "Anesthesiologists", "Classification", "I-III", "Normal", "cognitive", "function", "in", "order", "to", "sign", "written", ",", "informed", "consent", "and", "to", "understand", "trial", "protocol", "Agreement", "to", "the", "trial", "protocol", ",", "including", "the", "randomized", "manner" ]	[ "B-Person", "B-Value", "I-Value", "I-Value", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O" ]
[ "Irritable", "Bowel", "Syndrome", "(", "IBS", ")", "(", "ROME", "III", "criteria", ")", ":", "subtype", "with", "diarrhea", "or", "mixed", "form", "age", "18-65", "years" ]	[ "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "B-Person", "B-Value", "I-Value" ]
[ "Adult", "patients", "(", ">", "18", "years", ")", "scheduled", "for", "cardiopulmonary", "bypass", "surgery", "with", "Glomerular", "Filtration", "Rate", "(", "GFR", ")", "greater", "than", "or", "equal", "to", "60", "and", "left", "ventricular", "ejection", "fraction", "greater", "than", "or", "equal", "to", "40", "%" ]	[ "B-Person", "O", "O", "B-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value" ]
[ "Age", "<", "18", "years", "Creatinine", ">", "1.5", "mg/dL", "History", "of", "severe", "allergy", "to", "Iodine", "contrast", "agents", "Pregnancy", "Active", "atrial", "fibrillation", "Multiple", "premature", "ventricular", "or", "atrial", "contractions", "Ejection", "fraction", "<", "35", "%", "Class", "III", "congestive", "heart", "failure" ]	[ "B-Person", "B-Value", "I-Value", "I-Value", "B-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition" ]
[ "Adult", "men", "and", "women", ">", "18", "years", "old", "Presence", "of", "sustained", "ventricular", "tachycardia", "with", "HR", ">", "120", "bpm", "Systolic", "blood", "pressure", ">", "90", "mmHg", "No", "signs", "of", "poor", "peripheral", "perfusion", "Absence", "of", "dyspnea", "Absence", "of", "severe", "angina", "Signed", "consent", "form" ]	[ "B-Person", "B-Person", "O", "B-Person", "B-Value", "I-Value", "I-Value", "B-Person", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Mood", "I-Mood", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Condition", "B-Negation", "I-Negation", "B-Qualifier", "B-Condition", "I-Condition", "B-Informed_consent", "I-Informed_consent" ]
[ "Concomitant", "antiplatelet", "or", "anticoagulant", "use", "Calculated", "creatinine", "clearance", "<", "30", "mL/min", "by", "Cockcroft-Gault", "formula", "Alanine", "aminotransferase", "(", "ALT", ")", "or", "aspartate", "aminotransferase", "(", "AST", ")", ">", "3", "times", "upper", "limit", "of", "normal", "(", "ULN", ")", "Total", "bilirubin", ">", "2", "x", "ULN", "Thrombocytopenia", "<", "50", "x", "10", "gigalitres", "(", "Gl", ")", "High", "bleeding", "risk", "or", "spontaneously", "prolonged", "prothrombin", "time", "or", "activated", "partial", "thromboplastin", "time", ">", "1.5", "x", "ULN", "Body", "weight", "<", "50", "or", ">", "120", "kg", "Concomitant", "use", "of", "CYP3A4", "or", "p-glycoprotein", "inducers", "or", "inhibitors", "Use", "of", "Ginkgo", "biloba", "or", "St.", "John", "'s", "Wort", "within", "14", "days", "before", "first", "dose", "of", "study", "drug", "Dexamethasone", "use", "within", "last", "3", "months", "Women", "of", "Childbearing", "potential", "without", "proper", "contraceptive", "measures", ",", "pregnancy", "or", "breast", "feeding", "Life", "expectancy", "less", "than", "3", "months", "Inability", "to", "swallow", "or", "issues", "with", "malabsorption", "Any", "other", "medical", ",", "social", ",", "logistical", ",", "geographical", "or", "psychological", "factors", ",", "which", "in", "the", "opinion", "of", "the", "investigator", ",", "would", "prohibit", "follow-up", ",", "compliance", "and", "study", "completion" ]	[ "B-Temporal", "B-Drug", "O", "B-Drug", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "B-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Drug", "I-Drug", "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Person", "O", "B-Condition", "I-Condition", "B-Negation", "O", "B-Procedure", "I-Procedure", "O", "B-Condition", "O", "B-Observation", "I-Observation", "B-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement" ]
[ "dual", "organ", "transplant" ]	[ "B-Multiplier", "B-Procedure", "I-Procedure" ]
[ "Pregnant", "women", "admitted", "to", "Women", "health", "hospital", "with", "a", "diagnosis", "of", "severe", "pre-eclampsia" ]	[ "B-Condition", "B-Person", "B-Procedure", "I-Procedure", "B-Visit", "I-Visit", "I-Visit", "O", "O", "O", "O", "B-Qualifier", "B-Condition" ]
[ "•", "Diabetes", "duration", ">", "12", "years", "Currently", "taking", "more", "than", "three", "glucose", "lowering", "therapies", "Weight-loss", "of", ">", "5kg", "in", "the", "preceding", "6", "months", "Stage", "4", "or", "5", "chronic", "kidney", "disease", "(", "eGFR", "<", "30ml/min/1.73m2", ")", ",", "Current", "therapy", "with", "Insulin", ",", "thiazolidinediones", ",", "steroids", "or", "atypical", "antipsychotic", "medication", "Untreated", "thyroid", "disease", "Known", "macrovascular", "disease", "including", "coronary", "artery", "disease", ",", "stroke/TIA", "or", "peripheral", "vascular", "disease", "Presence", "of", "arrhythmia", "(", "including", "atrial", "fibrillation", ",", "atrial", "flutter", ",", "or", "2nd", "or", "3rd", "degree", "atrioventricular", "block", ")", "Known", "heart", "failure", "Other", "clinically", "relevant", "heart", "disease", "Inability", "to", "exercise", "or", "undertake", "a", "MRP", "Absolute", "contraindication", "to", "CMR", "Cardiovascular", "symptoms", "(", "angina", ",", "limiting", "dyspnoea", "during", "normal", "physical", "activity", ")", "Inflammatory", "condition", "e.g", ".", "Connective", "tissue", "disorder", ",", "Rheumatoid", "arthritis" ]	[ "O", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Observation", "I-Observation", "O", "B-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Observation", "I-Observation", "O", "O", "B-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition" ]
[ "Use", "of", "any", "oral", "antidiabetic", "treatment", "except", "for", "metformin", "(", "i.e.", ",", "sulphonylureas", ",", "DPP-IV", "inhibitors", ",", "thiazolidinediones", ",", "SGLT-2", "inhibitors", "(", "Sodium", "dependent", "glucose", "transporter", ")", "or", "GLP-1", "analogues", "(", "glucagone", "like", "peptide", ")", "within", "the", "last", "three", "months", "prior", "to", "Screening", "Repeated", "episodes", "of", "severe", "hypoglycaemia", "within", "the", "last", "six", "months", "prior", "to", "Screening", "History", "of", "diabetic", "ketoacidosis", ",", "precoma", "diabetica", ",", "or", "diabetic", "coma", "Treatment", "with", "any", "other", "investigational", "drug", "within", "the", "last", "three", "months", "before", "Screening", "Acute", "infections", "within", "the", "last", "four", "weeks", "prior", "to", "Screening", "Recurrent", "urogenital", "infections", "History", "of", "pancreatitis", "Anamnestic", "history", "of", "hypersensitivity", "to", "the", "study", "drugs", "or", "to", "drugs", "with", "similar", "chemical", "structures", "History", "of", "severe", "or", "multiple", "allergies", "Concomitant", "participation", "in", "other", "clinical", "trials", "Type", "1", "diabetes", "Cardiovascular", "disease", "Clinically", "relevant", "ventricular", "tachycardia", "or", "ventricular", "fibrillation", ",", "3rd", "degree", "AV", "block", "or", "Torsades", "de", "Pointes", "or", "treatment", "with", "antiarrhythmic", "drugs", ".", "Percutaneous", "coronary", "intervention", "within", "the", "past", "6", "months", ".", "Any", "of", "the", "following", "within", "the", "past", "6", "months", ":", "myocardial", "infarction", "(", "MI", ")", ",", "coronary", "artery", "bypass", "surgery", ";", "unstable", "angina", ";", "or", "stroke", ".", "Malignancy", "including", "leukemia", "and", "lymphoma", "within", "the", "last", "5y", ".", "Liver", "disease", "such", "as", "cirrhosis", "or", "chronic", "active", "hepatitis", ".", "Significant", "renal", "dysfunction", "(", "see", "also", "exclusion", "criteria", "laboratory", "abnormalities", ")", ".", "State", "after", "kidney", "transplantation", "Endocrine", "disease", ":", "Systolic", "blood", "pressure", "outside", "the", "range", "of", "100-160", "mmHg", "or", "diastolic", "blood", "pressure", "above", "95", "mmHg", "at", "Screening", "History", "of", "active", "substance", "abuse", "(", "including", "alcohol", ">", "40g/day", ")", "within", "the", "past", "2", "years", ".", "Pregnancy", "or", "childbearing", "potential", "without", "adequate", "contraception", "Present", "therapy", "with", "systemic", "steroids", "Presence", "of", "psychiatric", "disorder", "or", "intake", "of", "anti-depressive", "or", "anti-psychotic", "agents", "with", "the", "exception", "of", "benzodiazepines", "and", "SSRIs/SNRI", "'s", "(", "selective", "serotonin", "reuptake", "inhibitor", ")", "Potentially", "unreliable", "subjects", ",", "and", "those", "judged", "by", "the", "investigator", "to", "be", "unsuitable", "for", "the", "study", ".", "Contraindications", "for", "Magnetic", "resonance", "(", "MR", ")", "scanning", "such", "as", "persons", "with", "cardiac", "pacemaker", "and", "implants", "out", "of", "metal", "or", "claustrophobia" ]	[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Multiplier", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "O", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Multiplier", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "B-Qualifier", "I-Qualifier", "B-Condition", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "B-Drug", "I-Drug", "I-Drug", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Condition", "B-Procedure", "I-Procedure", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "B-Observation", "I-Observation", "I-Observation", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Negation", "I-Negation", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Drug", "O", "O", "O", "O", "O", "B-Non-representable", "I-Non-representable", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Device", "I-Device", "I-Device", "I-Device", "B-Device", "I-Device" ]

[ "Contraindication", "for", "the", "use", "of", "corticosteroids", "or", "local", "anesthetics", "Presence", "of", "inflammatory", "arthropathy", "or", "neuropathy", "Skin", "lesions", "in", "the", "area", "diabetes", "mellitus", "Infiltration", "or", "previous", "surgery", "in", "the", "area", "Refusal", "to", "participate", "in", "the", "study" ]

[ "B-Condition", "O", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "known", "allergy", "to", "any", "of", "drugs", "used", "coagulopathy", "any", "wound", "or", "infection", "related", "to", "puncture", "site", "major", "illness", "failure", "to", "gain", "consent", "of", "parents", "." ]

[ "O", "B-Condition", "O", "O", "O", "B-Drug", "I-Drug", "B-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "B-Observation", "I-Observation", "I-Observation", "I-Observation" ]

[ "Non-", "English", "speakers", "Height", "<", "4", "'", "11", "''", "BMI", ">", "40", "Kg/", "mm", "Antiemetic", "drug", "use", "in", "the", "24", "hours", "prior", "to", "cesarean", "delivery", ",", "Hypertensive", "diseases", "of", "pregnancy", "Chronic", "hypertension", "receiving", "antihypertensive", "treatment", "Any", "other", "physical", "or", "psychiatric", "condition", "that", "may", "impair", "their", "ability", "to", "cooperate", "with", "study", "data", "collection", "." ]

[ "B-Observation", "I-Observation", "I-Observation", "B-Measurement", "O", "B-Value", "I-Value", "I-Value", "O", "B-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "B-Drug", "I-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "diabetes", "mellitus", "secondary", "hypertension", "pregnancy" ]

[ "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition" ]

[ "Active", "alcohol", "or", "drug", "use", "or", "dependence", "which", "may", "interfere", "with", "adherence", "to", "study", "requirements", "HIV-infected", "at", "screening", "or", "enrollment", "Estimated", "CrCl", "<", "60", "mL/min", "Past", "participation", "in", "an", "HIV", "vaccine", "study", "Positive", "Hepatitis", "B", "surface", "antigen", "test", "Underlying", "medical", "condition", "with", "survival", "unlikely", "during", "follow-up", "period", "Any", "condition", "that", "in", "the", "opinion", "of", "study", "staff", "would", "make", "participation", "in", "the", "study", "unsafe", "or", "interfere", "with", "achieving", "study", "objectives", "Pregnant", "or", "breast", "feeding", "Actively", "trying", "to", "achieve", "pregnancy" ]

[ "B-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "I-Intoxication_considerations", "B-Condition", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Observation", "I-Observation", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations" ]

[ "No", "consent", "Spinal", "anesthesia", "or", "sciatic", "nerve", "block", "contraindicated", "Known", "intolerance", "to", "tramadol", "or", "other", "contraindications", "for", "the", "drug" ]

[ "B-Informed_consent", "B-Observation", "B-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Qualifier", "B-Condition", "I-Condition", "B-Drug", "I-Drug" ]

[ "diagnosed", "advanced", "heart", ",", "kidney", "or", "liver", "failure", "benign", "prostatic", "hyperplasia", "prostatic", "carcinoma", "frequent", "urinary", "tract", "infections", "non-type", "1", "diabetes", "mellitus" ]

[ "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Multiplier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition" ]

[ "Persistent", "primary", "or", "recurrent", "trans-sphincteric", "anal", "fistula" ]

[ "O", "B-Multiplier", "O", "B-Multiplier", "B-Condition", "I-Condition", "I-Condition" ]

[ "Patients", "with", "SOF/VEL", "treatment", "for", "the", "treatment", "of", "chronic", "HCV", "genotype", "1", "through", "6", ".", "Patient", "is", "at", "least", "18", "at", "the", "day", "of", "screening", ".", "Patient", "is", "able", "and", "willing", "to", "sign", "the", "Informed", "Consent", "Form", ".", "Patient", "is", "able", "and", "willing", "to", "follow", "protocol", "requirements", "." ]

[ "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Qualifier", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "Cardiac", "morbidities", "Hypertensive", "disorders", "of", "pregnancy", ",", "Peripartum", "bleeding", "Baseline", "systolic", "blood", "pressure", "(", "SBP", ")", "<", "100", "mmHg", "Body", "mass", "index", ">", "35" ]

[ "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement" ]

[ "Age", "=", "18", "years", "Laparoscopic", "cholecystectomy", "Emergent/elective", "=2", "risk", "factors", ":", "diabetes", "mellitus", ",", "age", "=70", "years", ",", "BMI", "=30", ",", "fascial", "enlargement" ]

[ "B-Person", "B-Value", "I-Value", "I-Value", "B-Qualifier", "B-Procedure", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Person", "B-Value", "I-Value", "I-Value", "B-Measurement", "B-Value", "B-Condition", "I-Condition" ]

[ "Adult", "male", "and", "female", "aged", "19", "to", "75", "years", "Voluntarily", "consented", "to", "participate", "in", "the", "study", "and", "signed", "the", "informed", "consent", "form", "after", "receiving", "the", "explanation", "of", "the", "objectives", ",", "methods", "and", "effects", "of", "the", "study", "." ]

[ "O", "B-Person", "O", "B-Person", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]

[ "Age", "<", "1m", "or", ">", "24", "months", "of", "age", "No", "secure", "diagnosis", "of", "epilepsy", "<", "4", "seizures/week", "on", "average", "in", "baseline", "period", "Trial", "of", "<", "2", "AEDs", "Continues", "on", "corticosteroids", "in", "previous", "3", "months", "prior", "to", "randomisation", "Metabolic", "disease", "contraindicating", "use", "of", "the", "ketogenic", "diet", "e.g", ".", "pyruvate", "carboxylase", "deficiency", ",", "MCAD", "from", "previous", "medical", "investigation", "and", "screening", "at", "baseline", ".", "Progressive", "neurological", "disease", "Severe", "gastroesophageal", "reflux", "Previous", "treatment", "with", "the", "ketogenic", "diet", "Concurrent", "participation", "in", "another", "clinical", "trial", "of", "an", "investigational", "medicinal", "product", ".", "Patients", "who", "are", "prescribed", "AEDs", "not", "listed", "in", "the", "trial", "IMPs" ]

[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "O", "O", "O", "B-Condition", "O", "B-Multiplier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "O", "O", "B-Procedure", "I-Procedure", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]

[ "Anticoagulant", "therapy", "during", "the", "past", "1", "week", "of", "the", "procedure", "Known", "coagulopathy", "History", "of", "liver", "cirrhosis", ",", "chronic", "kidney", "disease", ",", "malignancy", ",", "inflammatory", "bowel", "disease", ",", "significant", "infectious", "disease", ",", "polyposis", "syndrome" ]

[ "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Reference_point", "O", "B-Condition", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition" ]

[ "Prevalent", "NHHD", "patients", "who", "have", "received", ">", "1", "year", "dialysis", "with", "unfractionated", "heparin", "as", "anticoagulant", "Age", ">", "=", "18", "Informed", "consent", "available" ]

[ "O", "B-Condition", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "B-Procedure", "O", "B-Drug", "I-Drug", "O", "B-Drug", "B-Person", "O", "B-Value", "I-Value", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]

[ "History", "of", "significant", "head", "trauma", ",", "seizure", "disorder", ",", "or", "mental", "retardation", "History", "of", "alcohol", "or", "drug", "abuse", "or", "dependence", "within", "1", "month", "prior", "to", "study", "entry", "History", "of", "violence", "within", "6", "months", "prior", "to", "study", "entry" ]

[ "B-Temporal", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "O", "O", "O", "B-Condition", "B-Condition", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Temporal", "O", "B-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O" ]

[ "Children", "will", "be", "excluded", "if", "they", "have", "a", "history", "of", "developmental", "delay", "or", "inability", "to", "communicate", "the", "effects", "of", "an", "allergic", "reaction", "(", "non-verbal", ")", ".", "Any", "contraindication", "to", "allergy", "testing", "will", "also", "result", "in", "exclusion", "(", "i.e", ".", "history", "of", "a", "severe", "allergic", "reaction", "to", "skin", "tests", ",", ",", "anaphylaxis", "in", "the", "past", "six", "weeks", ",", "pregnancy", ",", "child", "took", "any", "antihistamine", "in", "the", "past", "three", "days", "[", "including", "diphenhydramine", "(", "Benadryl®", ")", ",", "cetirizine", "(", "Zyrtec®", ")", ",", "loratadine", "(", "Claritin®", ")", ",", "fexofenadine", "(", "Allegra®", ")", ",", "levocetirizine", "(", "Xyzal®", ")", ",", "and", "desloratadine", "(", "Clarinex®", ")", "]", "or", "child", "has", "a", "history", "of", "a", "condition", "that", "requires", "a", "beta", "blocker", "medicine", "for", "cardiac", "conditions", ",", "high", "blood", "pressure", ",", "migraine", "headaches", ",", "or", "eye", "drops", "for", "glaucoma", "(", "e.g", ".", "propranolol", ",", "metoprolol", ",", "atenolol", "and", "Timoptic®", ",", "or", "Betoptic®", "eye", "drops", ")", ".", "Children", "who", "present", "to", "the", "PED", "with", "a", "rash", ",", "vomiting", "or", "current", "asthma", "symptoms", "including", "coughing", ",", "wheezing", "or", "breathing", "problems", "will", "also", "be", "excluded", "to", "ensure", "these", "do", "not", "mask", "reactions", "to", "an", "oral", "challenge", ".", "Patients", "being", "admitted", "to", "the", "hospital", "or", "those", "who", "are", "deemed", "too", "acutely", "ill", "for", "participation", "(", "triage", "level", "1", "or", "2", "or", "as", "determined", "by", "the", "ED", "patient", "care", "team", ")", "will", "be", "excluded", "from", "the", "study", ".", "During", "this", "pilot", "study", ",", "we", "will", "exclude", "non-English", "speaking", "families", ".", "However", ",", "in", "subsequent", "studies", "we", "will", "include", "the", "non-English", "speaking", "population", ".", "Children", "who", "are", "wards", "of", "the", "state", ",", "in", "foster", "care", "or", "police", "custody", "or", "detention", "will", "be", "excluded", ".", "Children", "with", "any", "basal", "condition", "(", "trauma", ",", "infection", ",", "minor", "accidents", ",", "etc", "..", ")", "will", "be", "able", "to", "participate", "in", "the", "study", "provided", "they", "and", "their", "family", "are", "willing", "and", "do", "not", "meet", "the", "above-mentioned", "exclusion", "criteria", "." ]

[ "B-Person", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "O", "O", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Person", "I-Person", "I-Person", "O", "O", "O", "B-Visit", "I-Visit", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "O", "O", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "After", "half-dose", "ticagrelor", "(", "loading", "dose", "90mg", ",", "and", "then", "45mg", "bidpo", ".", ")", "treatment", "for", "3", "days", ",", "the", "platelet", "aggregation", "is", "effectively", "inhibited", "by", "light", "transmission", "aggregometry", "method", "and", "thromboela-stogram", ".", "planned", "to", "undergo", "PCI", "recently", "planned", "to", "DAPT", "for", "1", "year", "after", "PCI" ]

[ "O", "B-Multiplier", "B-Drug", "O", "B-Measurement", "I-Measurement", "B-Value", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Qualifier", "B-Value", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Procedure", "O", "B-Mood", "I-Mood", "I-Mood", "B-Procedure", "B-Temporal", "B-Mood", "I-Mood", "B-Procedure", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Temporal", "B-Reference_point" ]

[ "Patient", "refusal", "for", "supraclavicular", "block", "Inability", "to", "give", "informed", "consent", "Allergy", "to", "local", "anesthetics", "Hemidiaphragmatic", "dysfunction", ",", "suspected", "or", "known", "PNP", "Neuromuscular", "disease", "Obstructive", "or", "restrictive", "pulmonary", "disease", "Medical", "or", "anatomic", "contraindication", "to", "supraclavicular", "blockade", "as", "judged", "by", "clinician", "Pregnancy" ]

[ "B-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "B-Non-representable", "I-Non-representable", "I-Non-representable", "B-Condition" ]

[ "1", ".", "Prior", "Therapy", "Exposure", "to", "chemotherapy", "or", "radiotherapy", "within", "2", "weeks", "prior", "to", "entering", "the", "study", "or", "those", "who", "have", "not", "recovered", "from", "adverse", "events", "due", "to", "agents", "administered", "more", "than", "2", "weeks", "earlier", ".", "Systemic", "steroids", "that", "have", "not", "been", "stabilized", "(", "≥", "5", "days", ")", "to", "the", "equivalent", "of", "≤10", "mg/day", "prednisone", "prior", "to", "the", "start", "of", "the", "study", "drugs", ".", "No", "other", "investigational", "agents", "are", "allowed", ".", "2", ".", "History", "of", "allergic", "reactions", "to", "TGR-1202", "or", "carfilzomib", "3", ".", "Uncontrolled", "inter-current", "illness", "4", ".", "Pregnant", "women", "5", ".", "Nursing", "women", "6", ".", "Current", "malignancy", "or", "history", "of", "a", "prior", "malignancy", "7", ".", "Patient", "known", "to", "be", "Human", "Immunodeficiency", "Virus", "(", "HIV", ")", "-positive", "8", ".", "Active", "Hepatitis", "A", ",", "Hepatitis", "B", ",", "or", "Hepatitis", "C", "infection" ]

[ "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "O", "O", "B-Procedure", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "B-Negation", "B-Condition", "O", "B-Condition", "I-Condition", "B-c-Requires_causality", "I-c-Requires_causality", "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Drug", "I-Drug", "O", "O", "B-Negation", "O", "B-Qualifier", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Multiplier", "I-Multiplier", "B-Drug", "B-Temporal", "I-Temporal", "O", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Grammar_Error", "B-Drug", "I-Drug", "I-Drug", "I-Grammar_Error", "I-Grammar_Error", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Drug", "O", "B-Drug", "B-Parsing_Error", "I-Parsing_Error", "B-Undefined_semantics", "B-Condition", "I-Condition", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "B-Person", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "B-Person", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "B-Parsing_Error", "I-Parsing_Error", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Parsing_Error", "I-Parsing_Error", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O" ]

[ "<", "37", "weeks", "gestation", ",", "H/o", "Cesarean", "Section", ",", "Multiple", "Gestation", ",", "Pre-eclampsia", ",", "Narcotics", "within", "3", "hours", "prior", "to", "labor", "epidural", "placement", ",", "Chronic", "Pain", "(", "as", "defined", "by", "chronic", "opiate", "consumption", ")", ",", "Women", "who", "are", "participating", "in", "another", "study", "that", "will", "impact", "protocol" ]

[ "B-Value", "I-Value", "I-Value", "B-Measurement", "O", "B-Observation", "B-Procedure", "I-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Multiplier", "B-Drug", "O", "O", "O", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial" ]

[ "major", "elective", "gastrointestinal", ",", "gynecological", ",", "prostate", "or", "bladder", "surgery", "patients", "who", "are", "=", "60", "years", "old", ".", "the", "surgery", "is", "laparoscopic", "surgery", "and", "is", "expected", "to", "last", "for", "=", "2", "hours", "under", "general", "anesthesia", "and", "the", "patient", "will", "stay", "in", "hospital", "for", "at", "least", "7", "days", "after", "surgery", ".", "lack", "of", "serious", "hearing", "and", "vision", "impairment", "and", "be", "able", "to", "read", "so", "that", "neurobehavioral", "tests", "can", "be", "performed", "." ]

[ "O", "B-Qualifier", "B-Procedure", "O", "B-Procedure", "O", "B-Procedure", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Value", "I-Value", "I-Value", "B-Person", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Mood", "O", "B-Measurement", "O", "O", "B-Value", "I-Value", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "I-Negation", "I-Negation", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Mood", "I-Mood", "I-Mood", "I-Mood" ]

[ "Use", "of", "any", "investigational", "or", "non-registered", "product", "(", "drug", "or", "vaccine", ")", "other", "than", "the", "study", "vaccine", "(", "s", ")", "within", "30", "days", "preceding", "the", "first", "dose", "of", "study", "vaccine", ",", "or", "planned", "use", "during", "the", "study", "period", "Chronic", "administration", "(", "defined", "as", "more", "than", "14", "days", ")", "of", "immunosuppressants", "or", "other", "immune-modifying", "drugs", "within", "six", "months", "prior", "to", "the", "first", "vaccine", "dose", ".", "Planned", "administration/", "administration", "of", "a", "vaccine", "not", "foreseen", "by", "the", "study", "protocol", "during", "the", "period", "starting", "one", "month", "before", "each", "dose", "of", "vaccine", "(", "s", ")", "and", "ending", "7", "days", "after", "dose", "1", "and", "dose", "2", "or", "1", "month", "after", "dose", "3", ".", "Previous", "vaccination", "against", "diphtheria", ",", "tetanus", ",", "pertussis", ",", "polio", ",", "hepatitis", "B", ",", "Haemophilus", "influenzae", "type", "b", ",", "and/or", "S.", "pneumoniae", "with", "the", "exception", "of", "vaccines", "where", "the", "first", "dose", "can", "be", "given", "within", "the", "first", "two", "weeks", "of", "life", "according", "to", "the", "national", "recommendations", "History", "of", "or", "intercurrent", "diphtheria", ",", "tetanus", ",", "pertussis", ",", "hepatitis", "B", ",", "polio", ",", "and", "Haemophilus", "influenzae", "type", "b", "diseases", ".", "History", "of", "allergic", "disease", "or", "reactions", "likely", "to", "be", "exacerbated", "by", "any", "component", "of", "the", "vaccines", ".", "History", "of", "seizures", "(", "this", "criterion", "does", "not", "apply", "to", "subjects", "who", "have", "had", "a", "single", ",", "uncomplicated", "febrile", "convulsion", "in", "the", "past", ")", "or", "neurological", "disease", ".", "Acute", "disease", "at", "the", "time", "of", "enrolment", "Any", "confirmed", "or", "suspected", "immunosuppressive", "or", "immunodeficient", "condition", "based", "on", "medical", "history", "and", "physical", "A", "family", "history", "of", "congenital", "or", "hereditary", "immunodeficiency", ".", "Major", "congenital", "defects", "or", "serious", "chronic", "illness", ".", "Administration", "of", "immunoglobulins", "and/or", "any", "blood", "products", "since", "birth", "or", "planned", "administration", "during", "the", "active", "phase", "of", "the", "study", "." ]

[ "O", "O", "O", "O", "O", "B-Drug", "B-Drug", "O", "B-Drug", "O", "B-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Mood", "I-Mood", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "B-Mood", "O", "O", "O", "O", "B-Drug", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "B-Drug", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Negation", "I-Negation", "I-Negation", "I-Negation", "B-Drug", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Temporal", "O", "O", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Qualifier", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "O", "B-Condition", "O", "O", "O", "B-Negation", "I-Negation", "I-Negation", "O", "O", "O", "O", "O", "O", "B-Multiplier", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "B-Reference_point", "O", "B-Mood", "O", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O" ]

[ "Children", "(", "<", "18", "years", "old", ")", ".", "Women", "who", "are", "known", "to", "be", "pregnant", ".", "Any", "patient", "who", "has", "been", "previously", "randomized", "in", "the", "EvK", "Trial", ".", "Patients", "who", "require", "endotracheal", "intubation", "without", "sedative", "medication", ".", "For", "example", ",", "patients", "in", "full", "cardiac", "arrest", ".", "Patients", "with", "a", "known", "allergy", "to", "ketamine", "or", "etomidate", ".", "Any", "individual", "wearing", "a", "MedAlert", "bracelet", "indicating", "that", "he/she", "has", "formally", "opted", "out", "of", "the", "EvK", "Trial", "." ]

[ "B-Person", "O", "B-Value", "I-Value", "I-Value", "B-Person", "O", "O", "B-Person", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Temporal", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "B-Observation", "B-Procedure", "I-Procedure", "B-Negation", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition" ]

[ "1", ".", "Unable", "to", "ambulate", "at", "least", "150", "feet", "prior", "to", "stroke", ",", "or", "experienced", "intermittent", "claudication", "while", "walking", ";", "2.", "history", "of", "congestive", "heart", "failure", ",", "unstable", "cardiac", "arrhythmias", ",", "hypertrophic", "cardiomyopathy", ",", "severe", "aortic", "stenosis", ",", "angina", "or", "dyspnea", "at", "rest", "or", "during", "ADL", "'s", ";", "3", ".", "History", "of", "oxygen", "dependence", ";", "4", ".", "Preexisting", "neurological", "disorders", ",", "dementia", "or", "previous", "stroke", ";", "5", ".", "History", "of", "major", "head", "trauma", ";", "6", ".", "Legal", "blindness", "or", "severe", "visual", "impairment", ";", "7.", "history", "of", "psychosis", "or", "other", "Axis", "I", "disorder", "that", "is", "primary", ";", "8", ".", "Life", "expectancy", "<", "1", "yr.", ";", "9", ".", "Severe", "arthritis", "or", "other", "problems", "that", "limit", "passive", "range", "of", "motion", ";", "10", ".", "History", "of", "DVT", "or", "pulmonary", "embolism", "within", "6", "months", ";", "11", ".", "Uncontrolled", "diabetes", "with", "recent", "weight", "loss", ",", "diabetic", "coma", ",", "or", "frequent", "insulin", "reactions", ";", "12", ".", "Severe", "hypertension", "with", "systolic", ">", "200", "mmHg", "and", "diastolic", ">", "110", "mmHg", "at", "rest", ";", "13.", "attempt", "of", "suicide", "in", "the", "last", "2", "years", "or", "at", "suicidal", "risk", "assessed", "by", "SCID", "interview", ";", "14", ".", "Previous", "or", "current", "enrollment", "in", "a", "clinical", "trial", "to", "enhance", "motor", "recovery", ";", "15", ")", "currently", "exercising", "≥", "2", "times", "per", "week", "(", "≥20", "minutes", ")", ";", "16", ")", "Presence", "of", "non-MR", "compatible", "implants", ",", "pregnancy", "or", "severe", "claustrophobia", "." ]

[ "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Temporal", "O", "B-Reference_point", "O", "O", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "O", "B-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Temporal", "B-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Parsing_Error", "B-Temporal", "O", "B-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "O", "O", "B-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Temporal", "O", "B-Condition", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Qualifier", "B-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Multiplier", "B-Condition", "I-Condition", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Condition", "I-Condition", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Parsing_Error", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "O", "B-Parsing_Error", "I-Parsing_Error", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Parsing_Error", "I-Parsing_Error", "O", "O", "B-Device", "I-Device", "I-Device", "O", "B-Condition", "O", "B-Qualifier", "B-Condition", "O" ]

[ "Diagnosis", "of", "emphysema", "confirmed", "by", "CT", "scan", ".", "If", "a", "report", "of", "past", "CT", "scan", "is", "not", "available", "at", "site", "documenting", "then", "a", "CT", "scan", "is", "to", "be", "performed", "at", "screening", "Male", "or", "female", "patients", "at", "least", "18", "years", "of", "age", ".", "Able", "and", "willing", "to", "sign", "an", "informed", "consent", ".", "Patient", "with", "record", "of", "congenital", "AAT", "deficiency", "of", "phenotype", "PiZZ", "(", "homozygote", ")", "or", "other", "rare", "phenotypes", "related", "to", "AAT", "deficiency", "and", "with", "AAT", "serum", "level", "≤", "11", "micromole", ".", "For", "patients", "receiving", "IV", "AAT", "augmentation", "therapy", "the", "serum", "AAT", "level", "threshold", "does", "not", "apply", ".", "FEV1/SVC", "<", "70", "%", "of", "predicted", "value", "post", "bronchodilator", "(", "SVC", "is", "slow", "VC", ")", "and", "FEV1", "<", "80", "%", "of", "predicted", "value", "post-bronchodilator", "History", "of", "at", "least", "two", "moderate", "or", "severe", "exacerbations", "that", "required", "change", "in", "treatment", "(", "antibiotics", ",", "systemic", "steroids", ",", "hospitalization", ")", "in", "the", "last", "18", "months", "prior", "to", "date", "of", "screening", ",", "with", "at", "least", "one", "of", "these", "occurring", "within", "the", "last", "12", "months", "prior", "to", "screening", ".", "Ability", "to", "comply", "with", "completion", "of", "electronic", "diary", ".", "Ability", "to", "self-administer", "inhaled", "AAT", ".", "No", "significant", "abnormalities", "in", "serum", "hematology", ",", "serum", "chemistry", "and", "serum", "inflammatory", "/", "immunogenic", "markers", "according", "to", "the", "Principal", "Investigator", "'s", "judgment", ",", "taking", "into", "considerations", "the", "potential", "effects", "of", "the", "AAT", "deficiency", ".", "No", "significant", "abnormalities", "in", "urinalysis", "according", "to", "the", "Principal", "Investigator", "'s", "judgment", ",", "taking", "into", "considerations", "the", "potential", "effects", "of", "the", "AAT", "deficiency", ".", "No", "significant", "abnormalities", "in", "ECG", "per", "investigator", "judgment", ".", "Negative", "for", "HBsAg", "and", "for", "antibodies", "to", "HCV", ",", "HIV-1", ".", "AAT", "deficient", "patients", "who", "are", "either", "naïve", "(", "not", "receiving", "IV", "augmentation", "therapy", ")", "or", "AAT", "deficient", "patients", "(", "receiving", "IV", "augmentation", "therapy", ")", ",", "if", "they", "have", "been", "stable", "on", "regular", "therapy", "for", "at", "least", "3", "months", "prior", "to", "the", "screening", "visit", "and", "are", "willing", "to", "continue", "the", "same", "regime", "throughout", "this", "trial", ".", "Note", "that", "only", "sites", "in", "Germany", "can", "recruit", "patients", "who", "are", "currently", "being", "treated", "with", "IV", "AAT.Patients", "who", "stopped", "IV", "augmentation", "treatment", "6", "months", "prior", "to", "screening", "date", "and", "will", "not", "re-start", "this", "treatment", "for", "the", "course", "of", "the", "study", "will", "be", "considered", "Naïve", ".", "Non-pregnant", ",", "non-lactating", "female", "patients", ",", "whose", "screening", "pregnancy", "test", "is", "negative", "and", "who", "are", "using", "contraceptive", "methods", "deemed", "reliable", "by", "the", "investigator", ",", "or", "who", "are", "at", "least", "2", "years", "post-menopausal", "or", "surgically", "sterilized", "." ]

[ "O", "O", "B-Condition", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Observation", "I-Observation", "B-Temporal", "B-Procedure", "I-Procedure", "O", "B-Negation", "I-Negation", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Temporal", "B-Reference_point", "B-Person", "O", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Context_Error", "I-Context_Error", "I-Context_Error", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "B-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Reference_point", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Qualifier", "O", "B-Qualifier", "B-Condition", "O", "B-Qualifier", "B-Observation", "I-Observation", "B-Procedure", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "O", "B-Post-eligibility", "I-Post-eligibility", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "B-Observation", "I-Observation", "I-Observation", "I-Post-eligibility", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Subjective_judgement", "B-Qualifier", "B-Condition", "I-Condition", "B-Procedure", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Value", "O", "B-Measurement", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "B-Negation", "I-Negation", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "B-Qualifier", "O", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "O", "O", "O", "B-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Condition", "B-Person", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "O", "O", "B-Device", "I-Device", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "O", "B-Condition", "I-Condition", "O" ]

[ "Patients", "with", "craniotomy", "for", "supratentorial", "tumors", "under", "general", "anesthesia", "American", "Society", "of", "Anaesthesiologists", "(", "ASA", ")", "2", "and", "stable", "ASA", "3", "patients", "Elective", "surgery", "Patients", "with", "Glasgow", "Coma", "Scale", "(", "GCS", ")", "15/15" ]

[ "O", "O", "B-Procedure", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Qualifier", "B-Measurement", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "B-Value" ]

[ "Patients", "suspected", "to", "have", "vitamin", "B12", "deficiency", "defined", "as", "a", "plasma", "vitamin", "B12", "below", "the", "reference", "interval", "(", "<", "200", "pmol/L", ")", "." ]

[ "O", "B-Mood", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O" ]

[ "Patients", "presenting", "for", "abdominal", "myomectomy", "with", "documented", "uterine", "fibroids", "on", "pelvic", "imaging", "(", "pelvic", "ultrasound", "or", "MRI", ")", "within", "in", "last", "12", "months", "Age", "=", "18", "years", "and", "=", "50", "years", "Pre-operative", "hemoglobin", ">", "8", "g/dl", "Willing", "to", "have", "buccal", "administration", "of", "misoprostol", "or", "a", "placebo", "at", "least", "one", "hour", "pre-procedure", ".", "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", ".", "Admissible", "medical/surgical", "history", "Can", "be", "previously", "treated", "with", "Depo-Lupron", ",", "Depo-Provera", ",", "or", "Oral", "Contraceptive", "pills", "Intraoperative", "use", "of", "vasopressin", "and", "uterine", "tourniquet", "is", "permissible", "Can", "have", "had", "prior", "Cesarean", "delivery" ]

[ "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Reference_point", "B-Measurement", "I-Measurement", "O", "B-Value", "B-Mood", "I-Mood", "I-Mood", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "O", "B-Temporal", "B-Procedure", "I-Procedure", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable" ]

[ "Men", "or", "women", "aged", "18-60", "years", ".", "Primary", "psychiatric", "diagnosis", "of", "Major", "Depressive", "Disorder", ",", "without", "psychotic", "features", ",", "confirmed", "via", "SCID-IV", "structured", "diagnostic", "interview", ".", "Screening", "Hamilton", "Depression", "Rating", "Scale", "(", "HAMD", ")", "=", "18", ";", "and", "Baseline", "HAMD", "=", "15", ".", "If", "the", "patient", "is", "a", "woman", "of", "child-bearing", "potential", ",", "she", "must", "agree", "to", "use", "an", "acceptable", "form", "of", "birth", "control", "for", "duration", "of", "study", "participation", ".", "Able", "to", "understand", "and", "provide", "informed", "consent", "for", "participation", "." ]

[ "B-Condition", "I-Condition", "B-Person", "B-Person", "B-Value", "I-Value", "I-Condition", "B-Qualifier", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "B-Qualifier", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]

[ "long-term", "use", "of", "analgesics", ",", "sedatives", "or", "non", "steroidal", "anti-inflammatory", "drugs", "history", ".", "known", "for", "dexmedetomidine", "or", "other", "drugs", "allergy", "in", "this", "study", ".", "can", "not", "communicate", ".", "preoperative", "systolic", "blood", "pressure", "<", "90", "mmHg", ",", "or", "the", "heart", "rate", "<", "50/min", "." ]

[ "B-Multiplier", "I-Multiplier", "O", "B-Drug", "O", "B-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "O", "O", "O", "B-Drug", "O", "B-Qualifier", "B-Drug", "B-Condition", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value" ]

[ "At", "least", "18", "years", "of", "age", "Signed", "informed", "consent", "African", "American", "race", "History", "of", "a", "solitary", "renal", "transplant", "Stable", "tacrolimus", "dose", "for", "at", "least", "2", "weeks", "prior", "to", "randomization" ]

[ "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Value", "I-Value", "B-Person", "I-Person", "O", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "B-Qualifier", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point" ]

[ "NA" ]

[ "O" ]

[ "Patients", "receiving", "once", "daily", "dosing", "of", "methylprednisolone", "or", "prednisone", "in", "a", "dose", "of", "10", "mg/day", "or", "greater", "Hyperglycemic", "(", "Glucose", "level", ">", "126", "mg/dL", ")", "Diabetic", "and", "nondiabetic", "patients", "Expected", "duration", "of", "hospital", "stay", "and", "time", "on", "steroids", ">", "=", "3", "days", "Patient", "of", "appropriate", "caregiver", "able", "to", "give", "Informed", "Consent" ]

[ "O", "O", "B-Multiplier", "I-Multiplier", "O", "O", "B-Drug", "O", "B-Drug", "O", "O", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "B-Condition", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]

[ "Men", "and", "women", "older", "than", "18", "years", ",", "scheduled", "consecutively", "to", "perform", "a", "coronary", "procedure", "in", "the", "department", "of", "hemodynamics", "of", "the", "National", "Institute", "of", "Cardiology", "``", "Ignacio", "Chavez", "''", ".", "Patients", "may", "have", "any", "of", "the", "following", "indications", "for", "cardiac", "catheterization", ":", "Thoracic", "pain", "under", "study", ".", "Stable", "chronic", "coronary", "disease", ".", "Acute", "myocardial", "infarction", "with", "ST", "segment", "elevation", ",", "not", "perfused", "(", "without", "timely", "reperfusion", "therapy", ")", "with", "less", "than", "4", "weeks", "of", "evolution", ".", "Acute", "myocardial", "infarction", "with", "ST-segment", "elevation", ",", "successful", "thrombolytic", "therapy", ",", "which", "will", "undergo", "drug-invasive", "therapy", ".", "Acute", "myocardial", "infarction", "without", "ST", "segment", "elevation", ".", "Unstable", "angina", ".", "Any", "acute", "coronary", "syndrome", ",", "to", "intervene", "non-infarct-related", "artery", ".", "Disease", "of", "any", "heart", "valve", ".", "Myocarditis", "or", "pericarditis", ".", "Dilated", "cardiomyopathy", ".", "Patients", "in", "renal", "or", "cardiac", "transplantation", "protocol", "for", "any", "etiology", ".", "Congenital", "heart", "disease", "that", "requires", "knowing", "the", "coronary", "anatomy", "prior", "to", "surgical", "correction", ".", "The", "planned", "procedure", "can", "be", "any", "of", "the", "following", ":", "For", "diagnostic", "purposes", "(", "coronary", "angiography", "only", ",", "left", "catheterization", ",", "left", "and", "right", "catheterization", ")", ".", "For", "therapeutic", "purposes", ":", "percutaneous", "coronary", "intervention", "(", "PCI", ")", ",", "with", "or", "without", "stent", "placement", ".", "A", "priori", "access", "must", "be", "right", "or", "left", "radial", "artery", ".", "Radial", "arterial", "pulse", "may", "be", "present", "or", "absent", "by", "palpation", ".", "Modified", "Allen", "or", "Barbeau", "test", "should", "be", "positive", "(", "presence", "of", "collateral", "palmar", "flow", ")", "." ]

[ "B-Person", "O", "B-Person", "B-Value", "I-Value", "I-Value", "B-Person", "O", "B-Mood", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Visit", "I-Visit", "I-Visit", "O", "B-Visit", "I-Visit", "I-Visit", "I-Visit", "I-Visit", "O", "I-Visit", "I-Visit", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Negation", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Procedure", "B-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "O", "B-Procedure", "I-Procedure", "B-Qualifier", "I-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Qualifier", "I-Qualifier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "O", "B-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Value", "I-Value", "B-Value", "I-Value", "B-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition" ]

[ "NA" ]

[ "B-Non-query-able" ]

[ "Renal", "impairment", "Evidence", "or", "history", "of", "clinically", "significant", "allergic", "reactions", "to", "varenicline", "A", "cardiovascular", "event", "in", "the", "past", "month", "History", "of", "alcohol", "or", "drug", "dependence", "in", "the", "past", "year", "Major", "depressive", "disorder", "in", "the", "last", "year", "requiring", "treatment", "History", "of", "panic", "disorder", ",", "psychosis", ",", "bipolar", "disorder", ",", "or", "eating", "disorders", "Use", "of", "tobacco", "products", "other", "than", "cigarettes", "in", "past", "30", "days", "Use", "of", "pharmacotherapy", "in", "the", "month", "prior", "to", "enrollment", ",", "including", "prior", "use", "of", "varenicline", "Pregnant", ",", "contemplating", "getting", "pregnant", ",", "or", "breastfeeding", "Plans", "to", "move", "from", "Kansas", "City", "during", "the", "treatment", "and", "follow-up", "phase", "Another", "household", "member", "enrolled", "in", "the", "study", "Evidence", "of", "current", "severe", "major", "depressive", "disorder", "or", "suicidal", "ideation" ]

[ "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Temporal", "I-Temporal", "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Observation", "I-Observation", "O", "B-Negation", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition" ]

[ "indications", "to", "dual", "antiplatelet", "therapy", "other", "than", "atrial", "fibrillation", "or", "left", "atrial", "appendage", "occlusion", "at", "the", "time", "of", "enrollment", "or", "predicted", "appearance", "of", "such", "indications", "within", "the", "duration", "of", "the", "trial", "(", "eg", ".", "coronary", "artery", "disease", ")", "indications", "to", "anticoagulation", "at", "the", "time", "of", "enrollment", "or", "predicted", "appearance", "of", "such", "indications", "within", "the", "duration", "of", "the", "trial", "(", "eg", ".", "pulmonary", "embolism", ")", "known", "allergy", "to", "clopidogrel", "or", "acetylsalicylic", "acid", "precluding", "its", "administration", "as", "specified", "by", "the", "protocol", "any", "known", "inborn", "or", "acquired", "coagulation", "disorders", "poor", "tolerance", "of", "or", "technical", "difficulties", "with", "performing", "transesophageal", "echocardiography", "peridevice", "leak", ">", "5mm", "on", "transesophageal", "echocardiography", "study", "preceding", "enrollment", "left", "atrial", "thrombus", "on", "transesophageal", "echocardiography", "study", "performed", "after", "successful", "left", "atrial", "appendage", "closure", "but", "before", "enrollment", "life", "expectancy", "of", "less", "than", "18months", "participation", "in", "other", "clinical", "studies", "with", "experimental", "therapies", "at", "the", "time", "of", "enrollment", "and", "preceding", "3", "months", "chronic", "kidney", "disease", "stage", "IV", "and", "V", "women", "who", "are", "pregnant", "or", "breast", "feeding", ";", "women", "of", "childbearing", "potential", "who", "do", "not", "consent", "to", "apply", "at", "least", "to", "methods", "of", "contraception", ".", "This", "criterion", "does", "not", "apply", "to", "postmenopausal", "women" ]

[ "B-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Negation", "I-Negation", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Mood", "I-Mood", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Mood", "I-Mood", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Reference_point", "I-Reference_point", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Reference_point", "I-Reference_point", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Condition", "I-Condition", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations" ]

[ "Adult", "outpatients", "(", "18", "years", "or", "older", ")", "routinely", "referred", "for", "small", "bowel", "video", "capsule", "endoscopy", "(", "CE", ")" ]

[ "B-Person", "B-Visit", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Multiplier", "I-Multiplier", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O" ]

[ "pathological", "obesity", "chronic", "diseases", "e.g", ".", "cerebral", "palsy", ",", "metabolic", "disease", ",", "etc", ".", "diseases", "of", "red", "blood", "cells", "on", "medication", "e.g", ".", "steroid", ",", "multivitamins", ",", "thiamine-containing", "vitamins", ",", "diuretic", "drugs", "hemodialysis", "or", "peritoneal", "dialysis", "bariatric", "surgery" ]

[ "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure" ]

[ "Major", "subjects", "of", "over", "40", "years", "(", "mean", "age", "of", "Meniere", "'s", "disease", "40", "to", "50", "years", ")", "Informed", "consent", "signed", "Medical", "examination", "performed", "prior", "to", "participation", "in", "research", "Patients", "without", "history", "of", "inner", "ear", "disease", "Recipient", "of", "a", "French", "social", "security", "scheme" ]

[ "O", "O", "O", "B-Value", "I-Value", "B-Person", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Negation", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]

[ "Caucasian", "patients", "affected", "by", "uncomplicated", ",", "essential", "hypertension", ",", "not", "well", "controlled", "by", "concomitant", "administration", "of", "ACE-I", "or", "ARBs", "and", "diuretics", "at", "the", "maximum", "dosage", "." ]

[ "B-Person", "O", "O", "O", "B-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "B-Drug", "O", "B-Drug", "O", "B-Drug", "O", "O", "B-Multiplier", "I-Multiplier", "O" ]

[ "Risk", "of", "severe", "alcohol", "withdrawal", "(", "e.g", ".", "history", "of", "seizures", "or", "delirium", "tremens", ")", "Current", "Moderate", "or", "Severe", "Substance", "Use", "Disorder", ",", "other", "than", "Alcohol", ",", "Nicotine", "or", "Caffeine", "Use", "Disorders", "Lifetime", "history", "of", "Bipolar", "Disorder", ",", "Schizophrenia", "or", "Schizoaffective", "Disorder", "Any", "current", "psychiatric", "disorder", ",", "other", "than", "Alcohol", "Use", "Disorder", ",", "that", ",", "in", "the", "judgment", "of", "the", "investigator", ",", "will", "require", "treatment", "that", "will", "interfere", "with", "study", "participation", ".", "Current", "severe", "depression", "(", "HAM-D", ">", "24", ")", "or", "anxiety", "(", "HAM-A", ">", "24", ")", "Significant", "suicide", "or", "violence", "risk", "Currently", "taking", "any", "psychotropic", "medications", "Legally", "mandated", "to", "participate", "in", "treatment", "History", "of", "prior", "treatment", "with", "disulfiram", "Sufficiently", "socially", "unstable", "as", "to", "preclude", "participation", "(", "e.g", ".", "homeless", ")", "Contraindications", "to", "disulfiram", "treatment", "(", "liver", "disease", ",", "kidney", "disease", ",", "cardiac", "disease", ",", "seizure", "disorder", ",", "hypothyroidism", ",", "diabetes", "mellitus", ",", "pregnancy", "or", "lactation", ",", "allergy", "to", "disulfiram", "or", "thiuran", "derivatives", ")", "Neurological", "or", "medical", "conditions", "that", "would", "interfere", "with", "MRI", "scanning", "(", "e.g", ".", "history", "of", "stroke", ",", "seizure", ",", "brain", "tumor", ",", "brain", "infection", ",", "traumatic", "brain", "injury", ",", "multiple", "sclerosis", ",", "dementia", ",", "metal", "device", "in", "body", ",", "pregnancy", ",", "claustrophobia", ",", "color", "blindness", ",", "severe", "hearing", "impairment", ",", "weight", ">", "300", "lbs.", ",", "wheelchair-bound", ")", "Currently", "taking", "medications", "containing", "alcohol", ",", "metronidazole", ",", "isoniazid", ",", "paraldehyde", ",", "phenytoin", ",", "warfarin", ",", "or", "theophylline", ".", "Significant", "alcohol", "withdrawal", "(", "CIWA", ">", "8", ")", "at", "screening", ",", "after", "confirming", "a", "blood", "alcohol", "level", "of", "zero", "." ]

[ "B-Mood", "I-Mood", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "B-Temporal", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Temporal", "B-Qualifier", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Condition", "I-Condition", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Temporal", "B-Qualifier", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Drug", "I-Drug", "I-Drug", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Drug", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Device", "I-Device", "I-Device", "I-Device", "I-Device", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "B-Drug", "B-Drug", "I-Drug", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Value", "O", "B-Temporal", "I-Temporal", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement" ]

[ "History", "of", "allergic", "reaction", "to", "compounds", "of", "similar", "chemical", "or", "biologic", "composition", "to", "hCG", "receiving", "medication", "that", "could", "interfere", "with", "the", "study", "protocol", "objectives", "(", "hormonal", "contraceptives", ",", "androgens", ",", "prednisone", ",", "thyroid", "hormones", ",", "insulin", ")", "previous", "treatment", "with", "follicle", "stimulating", "hormone", "for", "assisted", "reproduction", "uncontrolled", "intercurrent", "illness", "Heart", "disease", "Severe", "cognitive", "decline", "Psychiatric", "desease", "HIV", "positive", "Hepatitis", "B", "or", "C", "infection" ]

[ "B-Temporal", "O", "B-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Temporal", "B-Drug", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Temporal", "B-Procedure", "I-Procedure", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Procedure", "I-Procedure", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition" ]

[ "The", "diagnosis", "of", "chronic", "bronchitis", "The", "diagnosis", "of", "community-acquired", "pneumoniae", "FEV1", "value", "=", "30-80", "%", "The", "diagnosis", "of", "mild-severe", "acute", "exacerbation", "of", "chronic", "bronchitis", "(", "AECB", ")", "Oxygen", "saturation", "<", "90", "%" ]

[ "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "B-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value" ]

[ "Women", "(", "18-75", "years", ")", "with", "suspected", "UTI", "at", "least", "two", "symptoms", "of", "UTI", "(", "dysuria", ",", "urgency", "of", "micturition", ",", "frequency", ",", "lower", "abdominal", "pain", ")", "Written", "informed", "consent" ]

[ "B-Person", "O", "B-Value", "B-Person", "O", "O", "B-Qualifier", "B-Condition", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "Established", "Osteoarthritis", "(", "Kellgren-Lawrence", ">", "3", ")", "Minimum", "joint", "space", ">", "2", "mm", "as", "measured", "on", "AP", "radiograph", "Hip", "dysplasia", "(", "center", "edge", "angle", "<", "20°", "on", "AP", "radiograph", ")", "Patients", "with", "clinically", "significant", "cardiovascular", ",", "renal", ",", "hepatic", ",", "endocrine", "disease", ",", "cancer", "or", "diabetes", "Patients", "with", "ongoing", "infection", "including", "HIV", "and", "Hepatitis", "Patient", "with", "history", "of", "osteomyelitis/septic", "arthritis", "Anticoagulation", "therapy", "Patients", "who", "are", "pregnant", "or", "breast", "feeding", "Patients", "with", "systemic", ",", "rheumatic", "or", "inflammatory", "disease", "of", "the", "knee", "or", "chondrocalcinosis", ",", "hemochromatosis", ",", "inflammatory", "arthritis", ",", "arthropathy", "of", "the", "knee", "associated", "with", "juxta-articular", "Paget", "'s", "disease", "of", "the", "femur", "or", "tibia", ",", "hemophilic", "arthropathy", ",", "infectious", "arthritis", ",", "Charcot", "'s", "knee", "joint", ",", "villonodular", "synovitis", ",", "and", "synovial", "chondromatosis", "Patients", "taking", "immunosuppressant", "medication", "Patients", "with", "abnormal", "hematology", "or", "serum", "chemistry", "lab", "results", "Patients", "receiving", "injection", "to", "treatment", "knee", "within", "2", "months", "of", "study", "enrollment", "BMI", "greater", "than", "35", "or", "less", "than", "20" ]

[ "O", "B-Condition", "O", "B-Measurement", "B-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "O", "O", "B-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Qualifier", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Parsing_Error", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O" ]

[ "Patients", "who", "had", "history", "of", "systemic", "antibiotic", "usage", "over", "the", "previous", "4", "months", "Patients", "who", "were", "pregnant", "Patients", "who", "had", "received", "non-surgical", "periodontal", "treatment", "within", "the", "past", "6", "months", "Patients", "who", "had", "received", "surgical", "periodontal", "treatment", "within", "the", "past", "12", "months", "Patients", "who", "were", "smokers", "Patients", "with", "a", "history", "of", "stroke", "or", "an", "acute", "cardiovascular", "event", "over", "the", "previous", "12", "months", "." ]

[ "O", "O", "O", "B-Temporal", "O", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]

[ "History", "of", "a", "primary", "sleep", "disorder", "other", "than", "RLS", "that", "may", "significantly", "affect", "the", "symptoms", "of", "RLS", ".", "Serum", "ferritin", "level", "<", "20", "ng/mL", "at", "screening", ".", "History", "of", "allergy", ",", "hypersensitivity", ",", "or", "intolerance", "to", "HORIZANT", "or", "any", "other", "gabapentin", "products", "(", "eg", ",", "Neurontin®", ",", "Gralise®", ")", ".", "Suffering", "from", "a", "movement", "disorder", "that", "could", "mimic", "or", "confound", "the", "accurate", "diagnosis", "of", "RLS", "(", "eg", ",", "Tourette", "'s", "syndrome", ",", "tic", "disorder", ",", "periodic", "limb", "movement", "disorder", "[", "PLMD", "]", ",", "sleep", "disorders", ")", ".", "Currently", "meet", "Diagnostic", "and", "Statistical", "Manual", "of", "Mental", "Disorders", "-", "Fifth", "Edition", "(", "DSM-5", ")", "criteria", "for", "substance", "use", "disorder", ",", "or", "history", "thereof", ",", "within", "12", "months", "before", "dosing", ".", "Current", "or", "past", "history", "of", "any", "significant", "psychiatric", "disorder", "including", ",", "but", "not", "limited", "to", ",", "depression", "(", "treatment", "with", "antidepressants", ")", ",", "bipolar", "disorder", ",", "or", "schizophrenia", ".", "Diagnosis", "of", "attention-deficit", "hyperactivity", "disorder", "(", "ADHD", ")", "is", "allowed", ",", "provided", "the", "patient", "is", "not", "receiving", "medication", "(", "s", ")", "known", "to", "affect", "the", "assessment", "of", "RLS", ".", "History", "of", "suicidal", "behavior", "or", "suicidal", "ideation", "as", "indicated", "by", "the", "C-SSRS", ",", "administered", "at", "screening", "(", "the", "questionnaire", "is", "provided", "in", "Appendix", "4", ")", ",", "and", "as", "per", "investigator", "'s", "judgment", ".", "History", "of", "seizure", "disorder", "or", "at", "increased", "risk", "for", "development", "of", "a", "seizure", "disorder", "including", ",", "but", "not", "limited", "to", ",", "complicated", "febrile", "seizure", "and", "history", "of", "significant", "head", "injury", ".", "Medical", "condition", "or", "disorder", "that", "would", "interfere", "with", "the", "action", ",", "absorption", ",", "distribution", ",", "metabolism", ",", "or", "excretion", "of", "gabapentin", "enacarbil", ",", "or", ",", "in", "the", "investigator", "'s", "judgment", "is", "considered", "to", "be", "clinically", "significant", "and", "may", "pose", "a", "safety", "concern", ",", "or", ",", "could", "interfere", "with", "the", "accurate", "assessment", "of", "safety", "or", "efficacy", ",", "or", "could", "potentially", "affect", "a", "patient", "'s", "safety", "or", "study", "outcome", ".", "Clinically", "significant", "abnormal", "laboratory", "result", "or", "physical", "examination", "finding", "not", "resolved", "by", "the", "time", "of", "baseline", "assessments", "." ]

[ "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "O", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Value", "I-Value", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Negation", "I-Negation", "I-Negation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]

[ "history", "of", "major", "systemic", "illness", ",", "including", "uncontrolled", "hypertension", ",", "diabetes", ",", "chronic", "renal", "insufficiency", ",", "autoimmune", "diseases", "or", "malignancies", "history", "of", "neurological", "disorders", "which", "might", "affect", "sensation", "such", "as", "previous", "stroke", "or", "peripheral", "neuropathy", "history", "of", "substance", "abuse", "(", "except", "painkillers", ")", "heavy", "smokers", "(", "with", "a", "daily", "consumption", ">", "20", "cigarettes", ")", "pregnancy", "or", "lactation", "any", "contraindication", "for", "magnetic", "resonance", "imaging", "(", "MRI", ")", "and", "any", "obvious", "infection", "or", "inflammation", "over", "a", "period", "of", "at", "least", "1", "month", "before", "the", "study", "." ]

[ "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "B-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "B-Drug", "I-Drug", "B-Qualifier", "B-Person", "I-Person", "I-Person", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "B-Observation", "I-Observation", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal" ]

[ "Healthy", "males", "between", "18", "and", "45", "years", "of", "age", "(", "inclusive", ")", ".", "Body", "mass", "index", "to", "be", "between", "18", "to", "30", "kg/m2", "(", "inclusive", ")", "as", "calculated", "by", "weight", "(", "Kg", ")", "/height", "(", "m2", ")", ".", "Subjects", "were", "to", "have", "no", "clinically", "significant", "abnormal", "findings", "on", "physical", "examination", ",", "ECG", ",", "medical", "history", ",", "or", "clinical", "laboratory", "results", "during", "screening", ".", "Subjects", "were", "to", ",", "in", "the", "opinion", "of", "the", "investigator", ",", "have", "no", "clinically", "significant", "abnormal", "findings", "of", "renal", "and", "hepatic", "function", "as", "determined", "by", "serum", "creatinine", ",", "total", "bilirubin", ",", "and", "transaminase", "levels", ".", "Subjects", "were", "to", "be", "non-users", "of", "tobacco", "products", "(", "minimum", "of", "6", "months", "prior", "to", "the", "start", "of", "the", "study", ")", ".", "Subjects", "were", "to", "have", "a", "negative", "screen", "for", "HIV", "I", "and", "II", ",", "HBsAg", ",", "and", "antibody", "to", "Hepatitis", "C", "virus", ".", "Subjects", "were", "to", "have", "a", "negative", "urine", "screen", "for", "alcohol", ",", "drugs", "of", "abuse", "(", "screening", "only", ")", ",", "and", "cotinine", ".", "Subjects", "were", "to", "use", "an", "appropriate", "barrier", "method", "of", "contraception", "(", "condom", "and", "spermicide", ")", "in", "addition", "to", "having", "their", "female", "partner", "use", "another", "form", "of", "barrier", "contraception", "(", "e.g.female", "condom", "or", "occlusive", "cap", "with", "spermicide", ")", "during", "the", "study", "and", "for", "3", "months", "following", "administration", "of", "the", "study", "drug", ".", "Subjects", "were", "able", "to", "comply", "with", "the", "protocol", "and", "the", "restrictions", "and", "assessments", "therein", ".", "Subjects", "were", "to", "give", "voluntary", "written", "informed", "consent", "to", "participate", "in", "the", "trial", "." ]

[ "B-Condition", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Negation", "B-Undefined_semantics", "I-Undefined_semantics", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "O", "B-Temporal", "I-Temporal", "O", "O", "B-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "O", "B-Negation", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "B-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "B-Measurement", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O" ]

[ "Patients", "who", "undergo", "iliac", "crest", "bone", "graft", "harvesting", "as", "part", "of", "their", "surgery", "Preexisting", "neurological", "deficits", "or", "peripheral", "neuropathy", "in", "the", "distribution", "of", "the", "sciatic", "nerve", "Local", "infection", "Contraindication", "to", "regional", "anesthesia", "e.g", ".", "bleeding", "diathesis", ",", "coagulopathy", "Chronic", "pain", "disorders", "History", "of", "use", "of", "over", "30mg", "oxycodone", "or", "equivalent", "per", "day", "Allergy", "to", "local", "anesthetics", "History", "of", "significant", "psychiatric", "conditions", "that", "may", "affect", "patient", "assessment", "Pregnancy", "Inability", "to", "provide", "informed", "consent" ]

[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Multiplier", "B-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Condition", "I-Condition", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]

[ "Previously", "enrolled", "in", "this", "study", "(", "i.e", ".", "patient", "now", "at", "repeat", "encounter", ")", "Concomitant", "surgical", "procedure", "other", "than", "CABG", "Anticoagulant", "treatment", "after", "the", "operation", "(", "e.g", ".", "warfarin", ",", "direct", "thrombin", "inhibitors", "(", "dabigatran", ")", ",", "FXa", "inhibitors", "(", "rivaroxaban", ",", "apixaban", ",", "heparin", ",", "low-molecular", "weight", "heparin", ",", "fondaparinux", ")", "Discharge", "from", "the", "operating", "hospital", "to", "an", "ICU", "at", "another", "hospital", "Pregnancy", "or", "lactation", "Known", "intolerance", "or", "contraindication", "to", "ticagrelor", "or", "ASA", "Any", "disorder", "that", "may", "interfere", "with", "drug", "absorption", "Any", "condition", "other", "than", "coronary", "artery", "disease", "with", "a", "life", "expectancy", "<", "12", "months", "Known", "chronic", "liver", "disease", ",", "renal", "disease", "requiring", "dialysis", "or", "bleeding", "disorder", "Atrioventricular", "block", "II", "and", "III", "in", "patients", "without", "pacemaker", "Any", "other", "indication", "for", "dual", "antiplatelet", "therapy", ",", "i.e", ".", "recent", "stent", "implantation", "Debilitating", "stroke", "within", "90", "days", "before", "inclusion", "Previous", "intracranial", "bleeding", "Treatment", "with", "immunosuppressants", "(", "e.g", ".", "cyclosporine", "and", "tacrolimus", ")", "Treatment", "with", "strong", "CYP3A4-inhibitors", "(", "e.g", ".", "ketoconazole", ",", "clarithromycin", ",", "nefazodone", ",", "ritonavir", "or", "atazanavir", ")", "Any", "condition", "that", "in", "the", "opinion", "of", "the", "investigator", "may", "interfere", "with", "adherence", "to", "trial", "protocol" ]

[ "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Procedure", "I-Procedure", "B-Qualifier", "I-Qualifier", "B-Procedure", "B-Procedure", "I-Procedure", "B-Temporal", "B-Reference_point", "B-Procedure", "I-Procedure", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Observation", "I-Observation", "O", "B-Visit", "I-Visit", "I-Visit", "O", "O", "B-Visit", "B-Qualifier", "B-Visit", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Negation", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Negation", "B-Device", "I-Device", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Procedure", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "B-Procedure", "I-Procedure", "I-Procedure", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "O", "B-Drug", "I-Drug", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able" ]

[ "History", "of", "falls", "or", "dizziness", "at", "exit", "from", "bed", "in", "the", "morning", "(", "at", "least", "two", "incidents", "in", "the", "past", "year", ")", "At", "least", "20/200", "corrected", "visual", "acuity", "Stable", "health", "Normal", "hearing" ]

[ "O", "O", "B-Condition", "O", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Condition", "B-Condition", "I-Condition" ]

[ "Overweight", "and", "obese", "PCOS", "patients", "with", "newly", "diagnosed", "IGR", ";", "PCOS", "diagnosis", "based", "on", "2003", "Rotterdam", "criteria", "Overweight", "/", "obesity", "diagnostic", "criteria", "according", "to", "WHO-WPR", "Impaired", "glucose", "regulation", "diagnostic", "criteria", "according", "to", "1998", "WHO", "diagnostic", "criteria", "." ]

[ "B-Condition", "O", "B-Condition", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier" ]

[ "Male", "and/or", "female", "patients", "from", "30-80", "years", "of", "age", "with", "a", "diagnosis", "of", "Type", "2", "diabetes", "(", "WHO", "criteria", ")", ".", "Incipient", "and", "established", "diabetic", "nephropathy", "(", "urinary", "albumin", "excretion", "≥", "100", "mg/day", "but", "≤", "2000", "mg/day", ")", ".", "Glomerular", "filtration", "rate", "(", "GFR", ")", "≥", "40", "ml/min", "(", "estimated", "using", "Modification", "of", "Diet", "in", "Renal", "Disease", "(", "MDRD", ")", "formula", ")", "in", "the", "last", "4", "months", ".", "Female", "patients", "must", "be", "postmenopausal", "or", "must", "have", "had", "a", "bilateral", "oophorectomy", "or", "must", "have", "been", "surgically", "sterilized", "or", "hysterectomized", "at", "least", "6", "months", "prior", "to", "screening", ".", "To", "be", "eligible", "patients", "must", "fulfill", "the", "following", "criteria", ":", "Patients", "on", "ongoing", "hypertensive", "therapy", "must", "have", "a", "blood", "pressure", "≥", "135/85", "mm", "Hg", "but", "lower", "than", "170/105", "mm", "Hg", "at", "baseline", "(", "Day", "-1", ")", "AND", "patients", "must", "be", "on", "stable", "antihypertensive", "medications", "for", "at", "least", "8", "weeks", "prior", "to", "baseline", "(", "Day", "-1", ")", ".", ";", "Newly", "diagnosed", "hypertensive", "patients", "must", "have", "a", "blood", "pressure", "≥", "135/85", "mm", "Hg", "but", "lower", "than", "170/105", "mm", "Hg", "at", "baseline", "(", "Day", "-1", ")", ".", "Patients", "must", "be", "on", "stable", "hypoglycemic", "medications", "for", "at", "least", "8", "weeks", "prior", "to", "Visit", "2", "(", "Day", "-1", ")", ".", "Patients", "must", "be", "willing", "and", "medically", "able", "to", "discontinue", "all", "Angiotensin-converting", "enzyme", "inhibitor", "(", "ACEI", ")", ",", "Angiotensin", "receptor", "blocker", "(", "ARB", ")", ",", "aldosterone", "receptor", "antagonist", "and", "potassium", "sparing", "diuretic", "medications", "for", "the", "duration", "of", "the", "study", ".", "Oral", "body", "temperature", "within", "the", "range", "35.0-37.5", "°C", "Able", "to", "provide", "written", "informed", "consent", "prior", "to", "study", "participation", ".", ".", "Able", "to", "communicate", "well", "with", "the", "investigator", "and", "comply", "with", "the", "requirements", "of", "the", "study", "." ]

[ "O", "O", "O", "O", "O", "B-Value", "I-Value", "B-Person", "I-Person", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Person", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Qualifier", "B-Drug", "I-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "B-Value", "I-Value", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O" ]

[ "A", "history", "of", "life-threatening", "asthma", "defined", "for", "this", "protocol", "as", "an", "asthma", "episode", "that", "required", "intubation", ",", "hypercapnea", "requiring", "non-invasive", "ventilatory", "support", ",", "respiratory", "arrest", ",", "hypoxic", "seizures", "or", "asthma-related", "syncopal", "episode", "(", "s", ")", ".", "Subjects", "with", "a", "history", "of", "asthma", "exacerbation", "requiring", "the", "use", "of", "systemic", "corticosteroids", "(", "tablets", ",", "suspension", ",", "or", "injection", ")", "for", "at", "least", "3", "days", "or", "a", "depot", "corticosteroid", "injection", "or", "emergency", "room", "attendance", "(", "within", "3", "months", ")", "or", "requiring", "hospitalization", "for", "asthma", "(", "within", "6", "months", ")", "prior", "to", "screening", ".", "Significant", ",", "non-reversible", "active", "pulmonary", "disease", "(", "e.g", ".", "cystic", "fibrosis", ",", "bronchiectasis", ",", "tuberculosis", ")", ".", "Culture-documented", "or", "suspected", "bacterial", "or", "viral", "infection", "of", "the", "upper", "or", "lower", "respiratory", "tract", ",", "sinus", "or", "middle", "ear", "that", "is", "not", "resolved", "within", "4", "weeks", "of", "Visit", "1", "and", "led", "to", "a", "change", "in", "asthma", "management", "or", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "is", "expected", "to", "affect", "the", "subject", "'s", "asthma", "status", "or", "the", "subject", "'s", "ability", "to", "participate", "in", "the", "study", ".", "Any", "fracture", "in", "the", "leg", "to", "be", "measured", "within", "6", "months", "prior", "to", "the", "screening", "visit", ".", "Any", "metabolic", "disorders", "or", "other", "diseases", "that", "may", "impact", "on", "normal", "growth", "patterns", ".", "No", "major", "surgery", "requiring", "general", "anaesthesia", "for", "at", "least", "3", "months", "prior", "to", "the", "screening", "visit", ".", "No", "febrile", "illnesses", "with", "temperature", ">", "39", "degree", "celsius", "for", "more", "than", "five", "consecutive", "days", "within", "the", "week", "preceding", "the", "Screening", "Visit", ".", "Any", "significant", "abnormality", "or", "medical", "condition", "identified", "at", "the", "screening", "medical", "assessment", "(", "including", "serious", "psychological", "disorder", ")", "that", "in", "the", "Investigator", "'s", "opinion", ",", "preclude", "entry", "into", "the", "study", "due", "to", "risk", "to", "the", "subject", "or", "that", "may", "interfere", "with", "the", "outcome", "of", "the", "study", ".", "Clinical", "visual", "evidence", "of", "candidiasis", "at", "Visit", "1", "(", "Screening", ")", ".", "Use", "of", "any", "of", "the", "prohibited", "medications", "listed", "in", "protocol", ".", "Strenuous", "physical", "exercise", "within", "3", "hours", "of", "Visit", "1", "(", "Screening", ")", "Drug", "allergies", ":", "Any", "adverse", "reaction", "including", "immediate", "or", "delayed", "hypersensitivity", "to", "any", "intranasal", ",", "inhaled", ",", "or", "systemic", "corticosteroid", "therapy", ".", "Known", "or", "suspected", "sensitivity", "to", "the", "constituents", "of", "the", "ELLIPTA", "Inhaler", "(", "i.e.", ",", "lactose", ",", "FF", ")", ".", "Milk", "Protein", "Allergy", ":", "History", "of", "severe", "milk", "protein", "allergy", ".", "The", "subject", "has", "participated", "in", "a", "clinical", "trial", "and", "has", "received", "an", "investigational", "product", "within", "the", "following", "time", "period", "prior", "to", "the", "first", "dosing", "day", "in", "the", "current", "study", ":", "30", "days", ",", "5", "half-lives", "or", "twice", "the", "duration", "of", "the", "biological", "effect", "of", "the", "investigational", "product", "(", "whichever", "is", "longer", ")", ".", "Exposure", "to", "more", "than", "4", "investigational", "medicinal", "products", "within", "12", "months", "prior", "to", "the", "first", "dosing", "day", ".", "Unable", "to", "use", "the", "ELLIPTA", "inhaler", "and", "peak", "flow", "meter", "correctly", ".", "An", "affiliation", "with", "the", "Investigator", "site", ":", "the", "parents/guardians", "or", "child", "is", "an", "immediate", "family", "member", "of", "the", "participating", "Investigator", ",", "sub-Investigator", ",", "study", "coordinator", ",", "or", "employee", "of", "the", "participating", "Investigator", ".", "The", "Parent", "or", "Guardian", "has", "a", "history", "of", "psychiatric", "disease", ",", "intellectual", "deficiency", ",", "substance", "abuse", "or", "other", "condition", "(", "e.g", ".", "inability", "to", "read", ",", "comprehend", "or", "write", ")", "which", "may", "affect", ":", "validity", "of", "consent", "to", "participate", "in", "the", "study", ";", "adequate", "supervision", "of", "the", "subject", "during", "the", "study", ";", "compliance", "of", "subject", "with", "study", "medication", "and", "study", "procedures", "(", "e.g", ".", "completion", "of", "daily", "diary", ",", "attending", "scheduled", "clinic", "visits", ")", ";", "subject", "safety", "and", "well-being", ".", "Children", "in", "care", ":", "Children", "who", "are", "wards", "of", "the", "government", "or", "state", "are", "not", "eligible", "for", "participation", "in", "this", "study", "." ]

[ "O", "B-Temporal", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "O", "B-Condition", "O", "B-Device", "I-Device", "I-Device", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Procedure", "O", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "B-Subjective_judgement", "O", "B-Qualifier", "B-Temporal", "B-Undefined_semantics", "I-Undefined_semantics", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "B-Procedure", "O", "B-Observation", "B-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Negation", "B-Qualifier", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "B-Observation", "I-Observation", "B-Procedure", "I-Procedure", "O", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "O", "O", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "O", "B-Negation", "B-Undefined_semantics", "I-Undefined_semantics", "O", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Negation", "B-Condition", "I-Condition", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Subjective_judgement", "B-Undefined_semantics", "B-Condition", "I-Subjective_judgement", "B-Condition", "I-Condition", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "O", "B-Condition", "I-Condition", "O", "B-Condition", "B-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "I-Context_Error", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Context_Error", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Drug", "O", "B-Drug", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "O", "B-Drug", "O", "B-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "B-Drug", "I-Drug", "I-Subjective_judgement", "B-Device", "I-Device", "I-Device", "I-Subjective_judgement", "I-Subjective_judgement", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O" ]

[ "Capacity", "to", "provide", "informed", "consent", "before", "any", "trial-related", "activities", "Established", "T2DM", "(", "=3months", ")", "HbA1c", "=", "9", "%", "if", "on", "triple", "therapy", "or", "=", "10", "%", "on", "diet", "&", "exercise", "or", "monotherapy", "or", "dual", "therapy", "Current", "glucose", "lowering", "therapy", "either", "mono", ",", "dual", "or", "triple", "of", "any", "combination", "of", "metformin", ",", "sulphonylurea", ",", "DPP-IV", "inhibitor", ",", "GLP-1", "therapy", "or", "an", "SGLT2", "+/-", "diet", "and", "exercise", "Poorly", "managed", "diet", "controlled", "diabetes", "(", "with", "HbA1c", ">", "6.5", "%", ",", "not", "currently", "taking", "any", "glucose", "lowering", "therapy", ",", "meeting", "BMI", "inclusion", "range", ")", "Body", "mass", "index", ">", "30Kg/m2", "or", ">", "27.5", "Kg/m2", "(", "South", "Asian", ")", ",", "Diagnosis", "of", "T2DM", "before", "the", "age", "of", "60", "years", "of", "age", "Age", "=18", "and", "=", "65", "years" ]

[ "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Measurement", "B-Temporal", "I-Temporal", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "B-Observation", "I-Observation", "B-Observation", "I-Observation", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "B-Condition", "B-Value", "I-Value", "O", "B-Person", "O", "O", "O", "O", "O", "B-Person", "B-Value", "I-Value", "I-Value" ]

[ "Preoperative", "Hemoglobin", "<", "U+2266", ">", "11", "g/dl", "History", "of", "infection", "or", "intraarticular", "fracture", "of", "the", "affective", "hip", "Renal", "function", "deficiency", "(", "GFR", "<", "30", "ml/min/1.73m2", ")", "Elevated", "liver", "enzyme", "(", "aspartate", "transaminase", "(", "AST", ")", "/", "alanine", "transaminase", "(", "ALT", ")", "level", "are", "more", "than", "twice", "normal", "range", ")", ",", "history", "of", "liver", "cirrhosis", ",", "impaired", "liver", "function", "(", "elevated", "total", "bilirubin", "level", ")", "and", "coagulopathy", "(", "including", "long-term", "use", "anticoagulant", ")", "History", "of", "deep", "vein", "thrombosis", ",", "ischemic", "heart", "disease", "or", "stroke", "Contraindications", "of", "tranexamic", "acid", ",", "floseal", ",", "or", "rivaroxaban", "Allergy", "to", "tranexamic", "acid", ",", "floseal", ",", "rivaroxaban", ",", "or", "the", "excipients", "History", "of", "heparin-induced", "thrombocytopenia", "(", "HIT", ")", "Coagulopathy", "or", "bleeding", "tendency", "caused", "by", "organ", "dysfunction", ",", "such", "as", "cirrhosis", ",", "bone", "marrow", "suppression", "etc", ".", "Patient", "who", "have", "active", "bleeding", "disorder", ",", "such", "as", "intracranial", "hemorrhage", ",", "upper", "gastrointestinal", "bleeding", ",", "hematuria", ".", "Patients", "with", "known", "allergies", "to", "materials", "of", "bovine", "origin", "." ]

[ "B-Temporal", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "O", "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Condition", "I-Condition", "I-Condition", "B-Multiplier", "I-Multiplier", "B-Drug", "I-Drug", "I-Drug", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "I-Drug" ]

[ "Acute", "coronary", "syndrome", "(", "ACS", ")", "within", "3", "months", ".", "Under", "beta-blocker", "treatment", "for", "the", "last", "2", "weeks", ".", "Under", "other", "medicine", "treatment", "which", "may", "affect", "heart", "rate", ",", "like", "Non-dihydropyridine", "calcium", "channel", "blockers", "(", "NDHP-CCBs", ")", "or", "ivabradine", "for", "the", "last", "2", "weeks", ";", "Under", "Digoxin", "treatment", "[", "more", "than", "(", ">", ")", "0.125", "milligram", "(", "mg", ")", "]", ".", "Uncontrolled", "Diabetes", "[", "hemoglobin", "A1c", ",", "(", "HbA1c", ")", ">", "7.5", "%", "]", ".", "Severe", "or", "uncontrolled", "hypertension", "[", "resting", "Systolic", "Blood", "Pressure", "(", "SBP", ")", ">", "180", "millimeters", "of", "mercury", "(", "mmHg", ")", ",", "or", "resting", "Diastolic", "Blood", "Pressure", "(", "DBP", ")", ">", "110mmHg", "at", "screening", "period", "]", ".", "Severe", "hypotension", "[", "resting", "SBP", "less", "than", "(", "<", ")", "90mmHg", ",", "or", "resting", "DBP", "<", "50mmHg", "]", ".", "Resting", "heart", "rate", "<", "60", "beat", "per", "minute", "(", "bpm", ")", ".", "Any", "contradiction", "to", "Bisoprolol", "according", "to", "label", ",", "including", ":", "Acute", "heart", "failure", "or", "during", "episodes", "of", "heart", "failure", "decompensation", "requiring", "intravenous", "inotropic", "therapy", ".", "Cardiogenic", "shock", ".", "Atrioventricular", "block", "of", "second", "or", "third", "degree", "(", "without", "a", "pacemaker", ")", ".", "Sick", "sinus", "syndrome", ".", "Sinoatrial", "block", ".", "Slowed", "heart", "rate", ",", "causing", "symptoms", "(", "symptomatic", "bradycardia", ")", ",", "Decreased", "blood", "pressure", ",", "causing", "symptoms", "(", "symptomatic", "hypotension", ")", ",", "Severe", "bronchial", "asthma", "or", "severe", "chronic", "obstructive", "pulmonary", "disease", ".", "Sever", "forms", "of", "peripheral", "arterial", "occlusive", "disease", "and", "Raynaud", "'s", "syndrome", ".", "Untreated", "phaeochromocytoma", ".", "Metabolic", "acidosis", ".", "Hypersensitivity", "to", "bisoprolol", "or", "to", "any", "of", "the", "excipients", ".", "Severe", "Arrhythmia", "including", "atrial", "fibrillation", ",", "atrial", "flutter", ",", "ventricular", "fibrillation", ",", "ventricular", "flutter", "or", "ventricular", "tachycardia", ".", "Significant", "valvular", "heart", "disease", ",", "congenital", "heart", "disease", ",", "pulmonary", "heart", "disease", "or", "perinatal", "heart", "disease", ".", "Acute", "pulmonary", "edema", ".", "Severe", "hepatic", "dysfunction", ",", "defined", "as", ":", "Serum", "Alanine", "Aminotransferase", "(", "ALT", ")", ">", "triple", "the", "upper", "limit", "of", "the", "normal", "range", ";", "and/or", "Serum", "Aspartate", "Aminotransferase", "(", "AST", ")", ">", "triple", "the", "upper", "limit", "of", "the", "normal", "value", "range", "and/or", "Severe", "renal", "dysfunction", ",", "defined", "as", ":", "Serum", "creatinine", ">", "twice", "the", "upper", "limit", "of", "the", "normal", "range", "Chronic", "Kidney", "Disease", "(", "glomerular", "filtration", "rate", "<", "45", "Milliliter", "per", "minute", ")", ".", "Hyperthyroidism", "or", "hypothyroidism", ".", "Severe", "infectious", "disease", ",", "example", "(", "eg", ")", "Human", "Immunodeficiency", "Virus", "positive", "or", "active", "tuberculosis", ".", "Severe", "autoimmune", "disease", ",", "e.g", ".", "lupus", "erythematosus", ",", "multiple", "sclerosis", ".", "Severe", "respiratory", ",", "digestive", ",", "hematological", "disease", "(", "including", "Anemia", "of", "Hb", "<", "100", "gram", "per", "litre", ")", "or", "tumor", ".", "Known", "to", "be", "hypersensitivity", "to", "Bisoprolol", ",", "or", "any", "of", "the", "excipient", ".", "Substance", "or", "alcohol", "abuse", ".", "Received", "heart", "transplantation", "or", "pacemaker", "implantation", ";", "revascularization", "treatment", "within", "3", "months", ";", "or", "plan", "to", "receive", "above", "treatment", "in", "6", "months", ".", "Currently", "undertaking", "other", "treatment", "that", "may", "affect", "the", "safety", "and/or", "efficacy", "evaluation", ",", "e.g", ".", "beta", "receptors", "agonists", ",", "et", "cetera", ".", "No", "legal", "ability", "or", "legal", "ability", "is", "limited", ".", "Subjects", "unlikely", "to", "cooperate", "in", "the", "study", "or", "with", "inability", "or", "unwillingness", "to", "give", "informed", "consent", ".", "Child-bearing", "period", "women", "without", "effective", "contraceptive", "measures", ",", "pregnancy", "and", "lactation", ".", "Participation", "in", "another", "clinical", "trial", "within", "the", "past", "90", "days", ".", "Other", "significant", "condition", "that", "in", "the", "Investigator", "'s", "opinion", "would", "exclude", "the", "subject", "from", "the", "trial", "." ]

[ "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "B-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Drug", "I-Drug", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "B-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "B-Value", "I-Value", "B-Reference_point", "I-Reference_point", "I-Temporal", "I-Temporal", "B-Qualifier", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Value", "I-Value", "I-Value", "B-Qualifier", "I-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Negation", "O", "B-Device", "I-Device", "I-Device", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Qualifier", "I-Qualifier", "O", "B-Drug", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Non-query-able", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Qualifier", "I-Qualifier", "B-Drug", "I-Drug", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Temporal", "I-Temporal", "O", "B-Mood", "I-Mood", "O", "O", "O", "B-Temporal", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "Patients", "will", "not", "be", "included", "if", "they", "have", "reached", "a", "stable", "dose", "of", "warfarin", ",", "liver", "dysfunction", ",", "alcoholism", ",", "use", "of", "another", "anticoagulant", ",", "use", "of", "chemotherapy", ",", "or", "if", "they", "do", "not", "meet", "the", "inclusion", "criteria" ]

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multiplier", "I-Multiplier", "O", "B-Drug", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "O", "O", "B-Qualifier", "B-Drug", "O", "O", "O", "B-Procedure", "O", "O", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "Has", "previously", "received", "Dapsone", "therapy", ".", "The", "subject", "or", "any", "of", "their", "healthcare", "providers", "is", "aware", "of", "the", "subjects", "HLA", "type", ".", "Has", "been", "diagnosed", "with", "Glucose-6-phosphate", "dehydrogenase", "deficiency", "or", "methemoglobin", "reductase", "deficiency", "Satisfies", "any", "contraindications", "or", "restrictions", "to", "Dapsone", "therapy", "as", "listed", "in", "the", "product", "labels", ".", "Current", "severe", "illness", ",", "including", "heart", ",", "liver", "and", "renal", "failure", ",", "major", "organ", "allograft", ",", "malignancy", "requiring", "parenteral", "chemotherapy", "that", "can", "not", "be", "discontinued", "for", "the", "duration", "of", "the", "trial", ",", "or", "any", "other", "conditions", "which", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "would", "make", "the", "patient", "unsuitable", "for", "the", "study", ".", "Any", "laboratory", "abnormality", "at", "Screening", "which", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "should", "preclude", "the", "subject", "'s", "participation", "in", "the", "study", "[", "alanine", "aminotransferase", "(", "ALT", ")", ",", "glutamic", "oxaloacetic", "transaminase", "(", "ALT", ")", ",", "et", "al", ")", ".", "Pregnant", "women", "or", "women", "who", "are", "breastfeeding", ".", "Subject", "is", ",", "in", "the", "opinion", "of", "the", "Investigator", ",", "unable", "to", "complete", "the", "6", "week", "Observation", "period", "and", "the", "EPT", "assessments", "as", "required", ".", "A", "positive", "result", "for", "HLA-B", "*", "1301", "in", "those", "subjects", "randomised", "to", "the", "genetic", "screening", "arm", "." ]

[ "O", "O", "O", "B-Drug", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Value", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "Age", ":", "from", "20", "to", "90", "y/o", ".", "HBsAg-positive", "for", "more", "than", "6", "months", "and", "HBV", "DNA", "<", "2000", "IU/ml", "(", "Subgroup", "1", ")", "or", "HBsAg-negative", "but", "anti-HBc", "positive", "with", "HBV", "DNA", "<", "2000", "IU/ml", "(", "Subgroup", "2", ")", ".", "Inflammatory", "arthritis", "patients", "who", "plan", "to", "treat", "with", "biological", "agents", ",", "including", "Humira", "or", "Enbrel", "or", "Simponi", "or", "Orencia", "or", "Mabthera", "or", "Actemra", ";", "as", "first", "line", "biologic", "treatment", "is", "indicated", "." ]

[ "B-Person", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "O", "O", "B-Value", "O", "B-Measurement", "B-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ "using", "daily", "medication", "for", "chronic", "condition", "acute", "narrow", "angle", "glaucoma", "previous", "adverse", "experience", "with", "study", "drugs", "experiences", "motion", "sickness", "in", "response", "to", "driving", "simulator", "BMI", ">", "30", "women", "who", "are", "pregnant", ",", "lactating", ",", "or", "planning", "on", "becoming", "pregnant", "regular", "use", "of", "tobacco", "products", "current", "substance", "use", "disorder", "clinically", "significant", "ECG", "current", "ongoing", "psychiatric", "disorder" ]

[ "O", "B-Multiplier", "B-Drug", "O", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Mood", "I-Mood", "I-Mood", "B-Condition", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Procedure", "B-Temporal", "B-Condition", "I-Condition" ]

[ "Contraindications", "for", "spinal", "anesthesia", "(", "like", "bleeding", "diathesis", "or", "regional", "infection", "at", "site", "of", "neuroaxial", "block", ")", "Known", "allergy", "to", "Granisetron", "or", "local", "anaesthetic", "(", "heavy", "bupivacaine", ",", "Marcaine", "Spinal", "0.5", "%", "Heavy", ",", "5mg/ml", ",", "AstraZeneca", "ampule", ")", "Pregnancy", "induced", "hypertension", "Congenital", "or", "rheumatic", "heart", "diseases", "Antepartum", "haemorrhage", "Fetal", "destress", "or", "gestational", "age", "<", "36", "week" ]

[ "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Condition", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Qualifier", "I-Qualifier", "B-Condition", "B-Qualifier", "I-Qualifier", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value" ]

[ "elective", "procedure", "weight", "over", "40", "kg", "American", "Society", "of", "Anesthesiology", "class", "I-III", "first", "upper", "GI", "endoscopy", "procedure", "finnish", "or/and", "swedish", "speaking" ]

[ "B-Procedure", "I-Procedure", "B-Measurement", "B-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Multiplier", "B-Qualifier", "I-Qualifier", "B-Procedure", "I-Procedure", "B-Observation", "I-Observation", "B-Observation", "I-Observation" ]

[ "Smoker", "or", "former", "smoker", ".", "Presence", "of", "dental", "prostheses", ".", "Presence", "of", "orthodontic", "devices", ".", "Antibiotic", "treatment", "or", "routine", "use", "of", "oral", "antiseptics", "in", "the", "previous", "3", "months", ".", "Presence", "of", "any", "systemic", "disease", "that", "could", "alter", "the", "production", "or", "composition", "of", "saliva", "." ]

[ "B-Condition", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Device", "I-Device", "I-Device", "O", "O", "B-Device", "I-Device", "I-Device", "B-Drug", "I-Drug", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier" ]

[ "ASA", "I-IV", "Age", "55", "or", "older", "Scheduled", "for", "operative", "repair", "of", "isolated", "intertrochanteric", "hip", "fracture" ]

[ "B-Line", "B-Value", "B-Line", "B-Value", "I-Value", "I-Value", "B-Line", "I-Line", "B-Procedure", "I-Procedure", "I-Line", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition" ]

[ "Currently", "pregnant", "or", "using", "a", "reliable", "contraception", "(", "e.g", ".", "injectables", ",", "intrauterine", "devices", ",", "implant", ",", "oral", "contraceptive", "pills", ")", "Desiring", "pregnancy", "in", "the", "next", "year", "History", "of", "tubal", "ligation", "or", "hysterectomy", "Contraindication", "to", "progestin-only", "contraceptives", "Unable", "to", "comprehend", "consent", "material", "because", "of", "language", "barrier", "or", "psychological", "difficulty" ]

[ "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "B-Non-query-able", "I-Non-query-able", "B-Qualifier", "B-Procedure", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "Advanced", "male", "factor", "infertility", ".", "Polycystic", "ovary", "syndrome", "(", "PCOS", ")", "as", "defined", "by", "the", "Rotterdam", "criteria", ".", "Endometriosis", ".", "Tubal", "disease", ".", "Uterine", "abnormalities", "or", "myoma", ".", "Previous", "uterine", "surgery", ".", "Metabolic", "or", "hormonal", "abnormalities", "." ]

[ "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Temporal", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition" ]

[ "Male", "or", "female", "patients", "=", "18", "and", "=", "85", "years", "of", "age", "Women", "of", "child", "bearing", "potential", "must", "test", "negative", "on", "standard", "pregnancy", "test", "(", "urine", "or", "serum", ")", "Patients", "with", "body", "weight", "=", "55", "kg", "and", "=", "140", "kg", "and", "body", "mass", "index", "(", "BMI", ")", "=", "18", "kg/m2", "Patients", "diagnosed", "severe", "sepsis", "/", "septic", "shock", "at", "admission", "on", "Intensive", "Care", "Unit", "who", "can", "be", "enrolled", "within", "90", "min", "after", "admission", "OR", "patients", "diagnosed", "severe", "sepsis", "/", "septic", "shock", "during", "Intensive", "Care", "Unit", "stay", "who", "can", "be", "enrolled", "within", "90", "min", "after", "diagnosis", "Patients", "where", "antibiotic", "therapy", "has", "already", "been", "started", "(", "prior", "to", "randomization", ")", "Patient", "who", "are", "fluid", "responsive", ".", "Fluid", "responsiveness", "is", "defined", "as", "increase", "of", ">", "10", "%", "in", "mean", "arterial", "pressure", "(", "MAP", ")", "after", "passive", "leg", "raising", "(", "PLR", ")", "Signed", "informed", "consent", "by", "patient", ",", "legal", "representative", "or", "authorized", "person", "or", "deferred", "consent" ]

[ "B-Person", "O", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "B-Person", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "O", "B-Measurement", "I-Measurement", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility" ]

[ "Subjects", "aged", "18", "years", "or", "older", ",", "at", "the", "time", "of", "signing", "the", "informed", "consent", ".", "Subjects", "with", "documented", "physician", "diagnosis", "of", "asthma", "as", "their", "primary", "respiratory", "disease", ".", "ACT", "score", "<", "20", "at", "screening", "visit", ".", "Non-smokers", "(", "never", "smoked", "or", "not", "smoking", "for", ">", "6", "months", "with", "<", "10", "pack", "years", "history", "(", "Pack", "years", "=", "[", "cigarettes", "per", "day", "smoked/20", "]", "multiplied", "by", "number", "of", "years", "smoked", ")", ".", "Male", "or", "female", "subjects", "will", "be", "included", ".", "A", "female", "subject", "is", "eligible", "to", "participate", "if", "she", "is", "not", "pregnant", ",", "not", "breastfeeding", ",", "and", "at", "least", "one", "of", "the", "following", "conditions", "applies", ":", "(", "i", ")", "Not", "a", "woman", "of", "childbearing", "potential", "(", "WOCBP", ")", ".", "(", "ii", ")", "A", "WOCBP", "who", "agrees", "to", "follow", "the", "contraceptive", "guidance", "during", "the", "treatment", "period", "and", "for", "at", "least", "5", "days", "]", "after", "the", "last", "dose", "of", "study", "treatment", ".", "Capable", "of", "giving", "signed", "informed", "consent", "which", "includes", "compliance", "with", "the", "requirements", "and", "restrictions", "listed", "in", "the", "consent", "form", "and", "protocol", ".", "Subject", "understands", "and", "is", "willing", ",", "able", ",", "and", "likely", "to", "comply", "with", "study", "procedures", "and", "restrictions", ".", "Subject", "must", "be", "able", "to", "read", "in", "a", "language", "supported", "by", "the", "smart", "phone", "app", "in", "their", "region", ".", "Subject", "must", "have", "been", "on", "maintenance", "therapy", "(", "Fixed", "dose", "combination", "ICS/LABA", ")", "for", "3", "months", ",", "can", "not", "have", "changed", "dose", "in", "the", "month", "prior", "to", "screening", "and", "be", "able", "to", "change", "to", "an", "equivalent", "dose", "of", "RELVAR/BREO", "for", "the", "duration", "of", "the", "study", ".", "Other", "background", "asthma", "medication", "such", "as", "anti-leukotrienes", "and", "oral", "corticosteroids", "are", "permitted", "provided", "the", "dose", "has", "been", "stable", "for", "1", "month", "prior", "to", "screening", ".", "Subject", "must", "be", "able", "to", "change", "to", "Salbutamol/Albuterol", "MDI", "rescue", "for", "the", "duration", "of", "the", "study", "and", "judged", "capable", "of", "withholding", "albuterol/salbutamol", "for", "at", "least", "6", "hours", "prior", "to", "study", "visits", ".", "Subject", "must", "have", "their", "own", "Android", "or", "iPhone", "operating", "system", "(", "IOS", ")", "smart", "phone", "and", "a", "data", "package", "suitable", "for", "the", "installation", "and", "running", "of", "the", "app", "and", "sending", "and", "receiving", "data", ".", "Data", "used", "by", "the", "CIS", "is", "approximately", "1", "megabyte", "(", "MB", ")", "per", "month", "as", "a", "maximum", ";", "this", "is", "less", "data", "than", "a", "1", "minute", "video", "streamed", "from", "YouTube", "(", "2MB", ")", ".", "Subjects", "must", "be", "willing", "and", "able", "to", "download", "the", "app", "on", "their", "personal", "smart", "phone", "and", "keep", "it", "turned", "on", "for", "the", "duration", "of", "the", "study", ".", "This", "will", "also", "require", "Bluetooth", "to", "be", "turned", "on", "for", "duration", "of", "the", "study", ".", "Subjects", "will", "also", "have", "to", "turn", "on", "mobile", "data", "for", "the", "app", "for", "the", "duration", "of", "study", ";", "unless", "travelling", "and", "when", "extra", "data", "roaming", "costs", "could", "be", "incurred", ".", "ACT", "score", "<", "20", "at", "randomization", "visit", "(", "visit", "2", ")", "." ]

[ "O", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Temporal", "I-Temporal", "I-Temporal", "B-Observation", "I-Observation", "B-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "B-Person", "B-Person", "I-Person", "O", "O", "O", "O", "O", "B-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "I-Pregnancy_considerations", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Multiplier", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Negation", "I-Negation", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "O", "O", "O", "B-Mood", "I-Mood", "B-Drug", "B-Drug", "B-Procedure", "I-Procedure", "I-Procedure", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "O", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "I-Drug", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "B-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "I-Non-query-able", "O", "B-Measurement", "I-Measurement", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal" ]

[ "1", ")", "preoperative", "diagnosis", "of", "delirium", "or", "dementia", ";", "2", ")", "MMSE", "score", "of", "=", "20", "out", "of", "30", "on", "preoperative", "testing", "(", "more", "than", "mild", "cognitive", "impairment", ")", "or", "delirium", "on", "preoperative", "CAM", "testing", ";", "3", ")", "language", "barriers", "that", "would", "preclude", "testing", ";", "4", ")", "preoperative", "steroid", "use", "within", "3", "days", "of", "surgery", ";", "or", "5", ")", "anticipation", "of", "postoperative", "intubation", "." ]

[ "B-Line", "I-Line", "B-Temporal", "I-Line", "I-Line", "B-Condition", "I-Line", "B-Condition", "I-Line", "B-Line", "I-Line", "B-Measurement", "I-Measurement", "I-Line", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Line", "B-Temporal", "I-Line", "I-Line", "B-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Line", "I-Line", "B-Condition", "I-Line", "B-Temporal", "B-Procedure", "I-Procedure", "I-Line", "B-Line", "I-Line", "B-Observation", "I-Observation", "I-Line", "I-Line", "I-Line", "I-Line", "I-Line", "B-Line", "I-Line", "B-Temporal", "B-Drug", "I-Line", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Line", "O", "B-Line", "I-Line", "B-Mood", "I-Line", "B-Temporal", "B-Procedure", "I-Line" ]

[ "Patients", "must", "be", "more", "than", "18", "years", "of", "age", "and", "referred", "for", "coronary", "angiography" ]

[ "O", "O", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure" ]

[ "latex", "allergy", "non-reassuring", "fetal", "status", "HIV", "active", "herpes", "outbreak", "Prior", "uterine", "scar", "Contraindication", "to", "prostaglandins", "according", "to", "current", "Parkland", "protocol", "Contraindication", "to", "vaginal", "delivery" ]

[ "B-Drug", "B-Condition", "B-Qualifier", "B-Condition", "I-Condition", "B-Condition", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Drug", "I-Drug", "O", "O", "B-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure" ]

[ "Systemic", "therapy", "or", "radiotherapy", "within", "4", "weeks", "prior", "to", "Day", "1", "Prior", "therapy", "with", "agents", "targeting", "the", "DR5", "apoptosis", "pathway", "Major", "surgical", "procedure", ",", "open", "biopsy", ",", "or", "significant", "traumatic", "injury", "within", "4", "weeks", "prior", "to", "Day", "1", ",", "or", "anticipation", "of", "need", "for", "major", "surgical", "procedure", "during", "the", "course", "of", "the", "study", "Other", "invasive", "malignancies", "within", "5", "years", "prior", "to", "Day", "1", "Known", "active", "brain", "metastases", "Uncontrolled", "intercurrent", "illness", ",", "including", "but", "not", "limited", "to", "ongoing", "or", "active", "infection", "requiring", "parenteral", "antibiotics", "at", "enrollment", "Clinically", "significant", ",", "symptomatic", "cardiovascular", "disease", ",", "New", "York", "Heart", "Association", "(", "NYHA", ")", "Grade", "II", "or", "greater", "congestive", "heart", "failure", ",", "serious", "cardiac", "arrhythmia", ",", "Grade", "II", "or", "greater", "peripheral", "vascular", "disease", ",", "or", "history", "of", "major", "heart", "surgery", "within", "6", "months", "of", "Day", "1", ",", "or", "any", "situation", "that", "would", "likely", "limit", "compliance", "with", "study", "requirements", "Known", "to", "be", "positive", "for", "hepatitis", "C", "or", "hepatitis", "B", "surface", "antigen", "History", "of", "other", "disease", ",", "metabolic", "dysfunction", ",", "physical", "examination", "finding", ",", "or", "clinical", "laboratory", "finding", "giving", "reasonable", "suspicion", "of", "a", "disease", "or", "condition", "that", "contraindicates", "use", "of", "an", "investigational", "drug", "or", "that", "might", "affect", "interpretation", "of", "the", "results", "of", "the", "study", "or", "render", "the", "patient", "at", "high", "risk", "for", "treatment", "complications", "Use", "of", "anticoagulation", "therapy", "Participation", "in", "clinical", "trials", "or", "undergoing", "other", "investigational", "procedures", "within", "30", "days", "prior", "to", "Day", "1", "Pregnancy", "or", "breast", "feeding", "Known", "sensitivity", "to", "any", "of", "the", "products", "administered", "during", "the", "study", "Any", "disorder", "that", "compromises", "the", "ability", "of", "the", "patient", "to", "give", "written", "informed", "consent", "and/or", "comply", "with", "study", "procedures" ]

[ "B-Procedure", "I-Procedure", "O", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Temporal", "B-Procedure", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Qualifier", "B-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "B-Mood", "I-Mood", "I-Mood", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "B-Qualifier", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "B-Temporal", "B-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "B-Temporal", "O", "B-Qualifier", "B-Condition", "O", "B-Drug", "I-Drug", "B-Temporal", "B-Reference_point", "B-Qualifier", "I-Qualifier", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Temporal", "I-Temporal", "B-Qualifier", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "B-Value", "O", "B-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Temporal", "O", "B-Qualifier", "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Mood", "I-Mood", "O", "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "I-Reference_point", "B-Condition", "O", "B-Observation", "I-Observation", "O", "B-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "O", "B-Negation", "I-Negation", "I-Negation", "I-Negation", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure" ]

[ "Primary", "kidney", "transplant", "recipients", ",", "adults" ]

[ "B-Qualifier", "B-Procedure", "I-Procedure", "O", "O", "B-Person" ]

[ "pregnancy", ",", "patients", "under", "legal", "custody", ",", "patients", "without", "health", "insurance", ",", "patients", "included", "in", "another", "interventional", "clinical", "study", "involving", "infections", "or", "antibiotics", "and", "having", "the", "same", "primary", "parameter", ",", "moribund", "patients", ",", "situation", "in", "which", "the", "procalcitonin", "concentration", "could", "be", "increased", "without", "correlation", "to", "an", "infectious", "process", "(", "poly-traumatised", "patients", ",", "surgical", "interventions", "within", "the", "last", "4", "days", ",", "cardiorespiratory", "arrest", ",", "administration", "of", "anti-thymocyte", "globulin", ",", "immunodepressed", "patients", "(", "bone", "marrow", "transplant", "patients", ",", "patients", "with", "severe", "neutropenia", ")", ",", "patients", "with", "an", "absolute", "indication", "for", "administration", "of", "antibiotics", "at", "the", "moment", "of", "ICU", "admission", "(", "meningitis", ",", "pneumonia", ")", "or", "a", "chronic", "infection", "for", "which", "long-term", "antibiotic", "treatment", "is", "necessary", "(", "endocarditis", ",", "osteo-articular", "infections", ",", "mediastinitis", ",", "deep", "abscesses", ",", "pneumocystis", "infection", ",", "toxoplasmosis", ",", "tuberculosis", ")", "patients", "with", "haemodynamic", "instability", "of", "septic", "origin", "or", "a", "respiratory", "insufficiency", "(", "defined", "by", "a", "ratio", "Pa02/Fi02", "=", "200", "mmHg", "and", "PEP", "=", "5", "cmH2O", ")" ]

[ "B-Condition", "O", "O", "O", "B-Person", "I-Person", "I-Person", "O", "B-Negation", "B-Person", "I-Person", "I-Person", "B-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "I-Competing_trial", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Qualifier", "I-Qualifier", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "B-Condition", "I-Condition", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "O", "B-Visit", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement" ]

[ "eGFR", "<", "60", "T2DM", "patients", "on", "insulin", ",", "GLP-1", "RA", "or", "SGLT2", "treatment", "Major", "organ", "disease", "type", "1", "diabetes" ]

[ "B-Line", "B-Value", "I-Value", "B-Line", "I-Line", "I-Line", "B-Drug", "I-Line", "B-Drug", "B-Drug", "I-Line", "B-Drug", "I-Line", "B-Line", "I-Line", "I-Line", "B-Line", "I-Line", "I-Line" ]

[ "Probable", "or", "definite", "diagnosis", "of", "autoimmune", "hepatitis", "according", "to", "the", "International", "Autoimmune", "Hepatitis", "Study", "Group", "criteria", "First", "presentation", "of", "AIH", "requiring", "treatment", "according", "to", "the", "current", "EASL", "guidelines", "Age", "=", "18", "years", "Must", "provide", "informed", "consent", "and", "agree", "to", "comply", "with", "the", "trial", "protocol" ]

[ "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "B-Condition", "O", "B-Procedure", "O", "O", "O", "O", "B-Measurement", "I-Measurement", "B-Person", "I-Person", "B-Value", "I-Value", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]

[ ">", "=", "18", "years", "old", "the", "day", "of", "inclusion", "Pregnancy", "Positive", "HBs", "Ag", "Informed", "consent", "obtained", "with", "information", "sheet", "given", "and", "explained", "and", "the", "consent", "form", "signed", "by", "the", "participant", "of", "the", "project", "investigator", "at", "the", "latest", "the", "day", "of", "the", "inclusion" ]

[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "O", "O", "O", "B-Condition", "B-Value", "B-Measurement", "I-Measurement", "B-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent", "I-Informed_consent" ]

[ "Pregnancy", ",", "coagulopathy", ",", "allergy", "to", "bupivacaine", ",", "renal", "failure", ",", "hepatic", "insufficiency", ",", "and/or", "inappropriate", "candidate", "for", "usual", "therapy", "(", "specifically", ",", "if", "unable", "to", "receive", "the", "usual", "preoperative", "interscalene", "nerve", "block", ":", "preexisting", "nerve", "injury", "on", "side", "of", "surgery", ",", "refusal", "of", "nerve", "block", ",", "infection", "at", "site", "of", "nerve", "block", ")", "." ]

[ "B-Condition", "O", "B-Condition", "O", "B-Condition", "O", "B-Drug", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Mood", "I-Mood", "I-Mood", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Temporal", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O" ]

[ "Able", "to", "give", "fully", "informed", "consent", "in", "writing", "Males", "or", "females", "aged", ">", "/=", "50", "years", "No", "significant", "disease", "or", "drug", "use", "Absence", "of", "any", "sign", "of", "dementia/cognitive", "impairment", "in", "neuropsychological", "examinationsPatients", "for", "brain", "imaging", ":", "Patient", "and", "designee", "capable", "of", "giving", "fully", "informed", "consent", "in", "writing", "Patient", "fulfils", "DSM-IV", "and", "NINCDS-ADRA", "criteria", "for", "probable", "Alzheimers", "disease" ]

[ "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "B-Person", "O", "B-Person", "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "B-Negation", "B-Subjective_judgement", "B-Condition", "O", "B-Condition", "I-Condition", "B-Negation", "I-Negation", "O", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "B-Procedure", "B-Parsing_Error", "I-Parsing_Error", "I-Parsing_Error", "I-Parsing_Error", "I-Parsing_Error", "B-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "I-Post-eligibility", "O", "B-Value", "B-Measurement", "O", "B-Measurement", "I-Measurement", "O", "B-Mood", "B-Condition", "I-Condition" ]

[ "Age", "=", "18", "years", "American", "Society", "of", "Anesthesiologists", "Classification", "I-III", "Normal", "cognitive", "function", "in", "order", "to", "sign", "written", ",", "informed", "consent", "and", "to", "understand", "trial", "protocol", "Agreement", "to", "the", "trial", "protocol", ",", "including", "the", "randomized", "manner" ]

[ "B-Person", "B-Value", "I-Value", "I-Value", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Value", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O" ]

[ "Irritable", "Bowel", "Syndrome", "(", "IBS", ")", "(", "ROME", "III", "criteria", ")", ":", "subtype", "with", "diarrhea", "or", "mixed", "form", "age", "18-65", "years" ]

[ "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "O", "O", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "B-Person", "B-Value", "I-Value" ]

[ "Adult", "patients", "(", ">", "18", "years", ")", "scheduled", "for", "cardiopulmonary", "bypass", "surgery", "with", "Glomerular", "Filtration", "Rate", "(", "GFR", ")", "greater", "than", "or", "equal", "to", "60", "and", "left", "ventricular", "ejection", "fraction", "greater", "than", "or", "equal", "to", "40", "%" ]

[ "B-Person", "O", "O", "B-Value", "I-Value", "B-Person", "O", "B-Mood", "I-Mood", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value" ]

[ "Age", "<", "18", "years", "Creatinine", ">", "1.5", "mg/dL", "History", "of", "severe", "allergy", "to", "Iodine", "contrast", "agents", "Pregnancy", "Active", "atrial", "fibrillation", "Multiple", "premature", "ventricular", "or", "atrial", "contractions", "Ejection", "fraction", "<", "35", "%", "Class", "III", "congestive", "heart", "failure" ]

[ "B-Person", "B-Value", "I-Value", "I-Value", "B-Measurement", "O", "B-Value", "I-Value", "O", "O", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition" ]

[ "Adult", "men", "and", "women", ">", "18", "years", "old", "Presence", "of", "sustained", "ventricular", "tachycardia", "with", "HR", ">", "120", "bpm", "Systolic", "blood", "pressure", ">", "90", "mmHg", "No", "signs", "of", "poor", "peripheral", "perfusion", "Absence", "of", "dyspnea", "Absence", "of", "severe", "angina", "Signed", "consent", "form" ]

[ "B-Person", "B-Person", "O", "B-Person", "B-Value", "I-Value", "I-Value", "B-Person", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "B-Mood", "I-Mood", "B-Condition", "I-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Condition", "B-Negation", "I-Negation", "B-Qualifier", "B-Condition", "I-Condition", "B-Informed_consent", "I-Informed_consent" ]

[ "Concomitant", "antiplatelet", "or", "anticoagulant", "use", "Calculated", "creatinine", "clearance", "<", "30", "mL/min", "by", "Cockcroft-Gault", "formula", "Alanine", "aminotransferase", "(", "ALT", ")", "or", "aspartate", "aminotransferase", "(", "AST", ")", ">", "3", "times", "upper", "limit", "of", "normal", "(", "ULN", ")", "Total", "bilirubin", ">", "2", "x", "ULN", "Thrombocytopenia", "<", "50", "x", "10", "gigalitres", "(", "Gl", ")", "High", "bleeding", "risk", "or", "spontaneously", "prolonged", "prothrombin", "time", "or", "activated", "partial", "thromboplastin", "time", ">", "1.5", "x", "ULN", "Body", "weight", "<", "50", "or", ">", "120", "kg", "Concomitant", "use", "of", "CYP3A4", "or", "p-glycoprotein", "inducers", "or", "inhibitors", "Use", "of", "Ginkgo", "biloba", "or", "St.", "John", "'s", "Wort", "within", "14", "days", "before", "first", "dose", "of", "study", "drug", "Dexamethasone", "use", "within", "last", "3", "months", "Women", "of", "Childbearing", "potential", "without", "proper", "contraceptive", "measures", ",", "pregnancy", "or", "breast", "feeding", "Life", "expectancy", "less", "than", "3", "months", "Inability", "to", "swallow", "or", "issues", "with", "malabsorption", "Any", "other", "medical", ",", "social", ",", "logistical", ",", "geographical", "or", "psychological", "factors", ",", "which", "in", "the", "opinion", "of", "the", "investigator", ",", "would", "prohibit", "follow-up", ",", "compliance", "and", "study", "completion" ]

[ "B-Temporal", "B-Drug", "O", "B-Drug", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Measurement", "I-Measurement", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "B-Value", "I-Value", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "I-Reference_point", "I-Reference_point", "B-Drug", "I-Drug", "B-Drug", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Person", "O", "B-Condition", "I-Condition", "B-Negation", "O", "B-Procedure", "I-Procedure", "O", "B-Condition", "O", "B-Observation", "I-Observation", "B-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "I-Condition", "I-Condition", "O", "B-Undefined_semantics", "I-Undefined_semantics", "I-Undefined_semantics", "B-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement", "I-Subjective_judgement" ]

[ "dual", "organ", "transplant" ]

[ "B-Multiplier", "B-Procedure", "I-Procedure" ]

[ "Pregnant", "women", "admitted", "to", "Women", "health", "hospital", "with", "a", "diagnosis", "of", "severe", "pre-eclampsia" ]

[ "B-Condition", "B-Person", "B-Procedure", "I-Procedure", "B-Visit", "I-Visit", "I-Visit", "O", "O", "O", "O", "B-Qualifier", "B-Condition" ]

[ "•", "Diabetes", "duration", ">", "12", "years", "Currently", "taking", "more", "than", "three", "glucose", "lowering", "therapies", "Weight-loss", "of", ">", "5kg", "in", "the", "preceding", "6", "months", "Stage", "4", "or", "5", "chronic", "kidney", "disease", "(", "eGFR", "<", "30ml/min/1.73m2", ")", ",", "Current", "therapy", "with", "Insulin", ",", "thiazolidinediones", ",", "steroids", "or", "atypical", "antipsychotic", "medication", "Untreated", "thyroid", "disease", "Known", "macrovascular", "disease", "including", "coronary", "artery", "disease", ",", "stroke/TIA", "or", "peripheral", "vascular", "disease", "Presence", "of", "arrhythmia", "(", "including", "atrial", "fibrillation", ",", "atrial", "flutter", ",", "or", "2nd", "or", "3rd", "degree", "atrioventricular", "block", ")", "Known", "heart", "failure", "Other", "clinically", "relevant", "heart", "disease", "Inability", "to", "exercise", "or", "undertake", "a", "MRP", "Absolute", "contraindication", "to", "CMR", "Cardiovascular", "symptoms", "(", "angina", ",", "limiting", "dyspnoea", "during", "normal", "physical", "activity", ")", "Inflammatory", "condition", "e.g", ".", "Connective", "tissue", "disorder", ",", "Rheumatoid", "arthritis" ]

[ "O", "B-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Observation", "I-Observation", "O", "B-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "B-Negation", "I-Negation", "B-Observation", "I-Observation", "O", "O", "B-Procedure", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition" ]

[ "Use", "of", "any", "oral", "antidiabetic", "treatment", "except", "for", "metformin", "(", "i.e.", ",", "sulphonylureas", ",", "DPP-IV", "inhibitors", ",", "thiazolidinediones", ",", "SGLT-2", "inhibitors", "(", "Sodium", "dependent", "glucose", "transporter", ")", "or", "GLP-1", "analogues", "(", "glucagone", "like", "peptide", ")", "within", "the", "last", "three", "months", "prior", "to", "Screening", "Repeated", "episodes", "of", "severe", "hypoglycaemia", "within", "the", "last", "six", "months", "prior", "to", "Screening", "History", "of", "diabetic", "ketoacidosis", ",", "precoma", "diabetica", ",", "or", "diabetic", "coma", "Treatment", "with", "any", "other", "investigational", "drug", "within", "the", "last", "three", "months", "before", "Screening", "Acute", "infections", "within", "the", "last", "four", "weeks", "prior", "to", "Screening", "Recurrent", "urogenital", "infections", "History", "of", "pancreatitis", "Anamnestic", "history", "of", "hypersensitivity", "to", "the", "study", "drugs", "or", "to", "drugs", "with", "similar", "chemical", "structures", "History", "of", "severe", "or", "multiple", "allergies", "Concomitant", "participation", "in", "other", "clinical", "trials", "Type", "1", "diabetes", "Cardiovascular", "disease", "Clinically", "relevant", "ventricular", "tachycardia", "or", "ventricular", "fibrillation", ",", "3rd", "degree", "AV", "block", "or", "Torsades", "de", "Pointes", "or", "treatment", "with", "antiarrhythmic", "drugs", ".", "Percutaneous", "coronary", "intervention", "within", "the", "past", "6", "months", ".", "Any", "of", "the", "following", "within", "the", "past", "6", "months", ":", "myocardial", "infarction", "(", "MI", ")", ",", "coronary", "artery", "bypass", "surgery", ";", "unstable", "angina", ";", "or", "stroke", ".", "Malignancy", "including", "leukemia", "and", "lymphoma", "within", "the", "last", "5y", ".", "Liver", "disease", "such", "as", "cirrhosis", "or", "chronic", "active", "hepatitis", ".", "Significant", "renal", "dysfunction", "(", "see", "also", "exclusion", "criteria", "laboratory", "abnormalities", ")", ".", "State", "after", "kidney", "transplantation", "Endocrine", "disease", ":", "Systolic", "blood", "pressure", "outside", "the", "range", "of", "100-160", "mmHg", "or", "diastolic", "blood", "pressure", "above", "95", "mmHg", "at", "Screening", "History", "of", "active", "substance", "abuse", "(", "including", "alcohol", ">", "40g/day", ")", "within", "the", "past", "2", "years", ".", "Pregnancy", "or", "childbearing", "potential", "without", "adequate", "contraception", "Present", "therapy", "with", "systemic", "steroids", "Presence", "of", "psychiatric", "disorder", "or", "intake", "of", "anti-depressive", "or", "anti-psychotic", "agents", "with", "the", "exception", "of", "benzodiazepines", "and", "SSRIs/SNRI", "'s", "(", "selective", "serotonin", "reuptake", "inhibitor", ")", "Potentially", "unreliable", "subjects", ",", "and", "those", "judged", "by", "the", "investigator", "to", "be", "unsuitable", "for", "the", "study", ".", "Contraindications", "for", "Magnetic", "resonance", "(", "MR", ")", "scanning", "such", "as", "persons", "with", "cardiac", "pacemaker", "and", "implants", "out", "of", "metal", "or", "claustrophobia" ]

[ "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "B-Negation", "I-Negation", "B-Drug", "O", "O", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "B-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Multiplier", "O", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "B-Procedure", "I-Procedure", "O", "O", "B-Drug", "I-Drug", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Reference_point", "B-Multiplier", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "B-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Temporal", "I-Temporal", "B-Qualifier", "I-Qualifier", "B-Condition", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "B-Procedure", "B-Drug", "I-Drug", "I-Drug", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Condition", "B-Procedure", "I-Procedure", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "B-Temporal", "I-Temporal", "I-Temporal", "B-Temporal", "B-Qualifier", "I-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "B-Condition", "B-Observation", "I-Observation", "I-Observation", "B-Qualifier", "B-Procedure", "I-Procedure", "I-Procedure", "B-Procedure", "I-Procedure", "B-Drug", "I-Drug", "I-Drug", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Drug", "I-Drug", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "B-Negation", "I-Negation", "B-Drug", "I-Drug", "I-Drug", "B-Drug", "B-Drug", "O", "O", "O", "O", "O", "B-Non-representable", "I-Non-representable", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "I-Non-representable", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "B-Condition", "I-Condition", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "O", "B-Device", "I-Device", "I-Device", "I-Device", "B-Device", "I-Device" ]