@article{SchorrLiBarPeledetal.1999, author = {Kristel Schorr and Minglin Li and Ud Bar-Peled and Albert Lewis and Alonso Heredia and Bernadette Lewis and C. Michael Knudson and Stanley J. Korsmeyer and Richard J{\"a}ger and Hans Weiher and Priscilla A. Furth}, title = {Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo}, series = {Cancer Research}, volume = {59}, number = {11}, publisher = {American Association for Cancer Research}, issn = {1538-7445}, pages = {2541 -- 2545}, year = {1999}, abstract = {The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50\% during the first stage and increased cell survival 70\% during the second stage. Complete loss of Bax reduced apoptosis by 20\% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.}, language = {en} }