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Biological Regulation

The extracellular matrix as captured by a scanning electron microscope (SEM)

Changes to the extracellular matrix could point to the future development of inflammatory bowel diseases

When the Beads Line Up

Conserved elements reveal vital spots in the noncoding, regulatory, portions of the genome 

Hijacking the Host Defenses Gives Bacteria an Advantage

A metabolic switch in microbe-fighting macrophages signals bacteria to convert them to hotels with amenities 

cells that remember their identity

Cancer cells turn out to have memories. But these are unreliable and can end up causing trouble

immune cells in cancer

A possible cause for cancer resistance to immunotherapy could be reversed

When the NXF1 gene functions properly (left), RNA molecules (orange dots) of a particular single-exon gene are exported from the nucleus (purple) into the cytoplasm; when the NXF1 is silenced (right), the RNAs are largely stuck within the nucleus

Cells use two separate routes to export RNA out of the nucleus

zebra fish swimming

Researchers uncover a see-through secret to heart repair

Laboratory analysis of a mouse brain shows the enzyme ASL (purple) prominently expressed in the locus coeruleus in the brainstem

Deficiency of a common substance could be linked to cognitive and behavioral problems

Igor Ulitsky

A non-coding gene’s neighbors reveal what it does for a “living.” The findings may pave the way to developing therapies for epilepsy and autism...

Irit Sagi

Institute scientists have developed a potential drug that attenuates autism-like behaviors in disease models