@article {13426, title = {Prior human polyomavirus and papillomavirus infection and incident lung cancer: a nested case-control study.}, journal = {Cancer causes \& control : CCC}, volume = {26}, year = {2015}, month = {12/2015}, pages = {1835-1844}, chapter = {1835}, abstract = {

PURPOSE: To test whether infection with select human polyomaviruses (HPyV) and human papillomaviruses (HPV) is associated with incident lung cancer. METHODS: We performed a nested case-control study, testing serum from the carotene and retinol efficacy trial, conducted 1985-2005, for antibodies to Merkel cell (MCV), KI (KIV), and WU (WUV) HPyVs as well as to six high-risk and two low-risk HPV types. Incident lung cancer cases (n\ =\ 200) were frequency-matched with controls (n\ =\ 200) on age, enrollment and blood draw dates, intervention arm assignment, and the number of serum freeze/thaw cycles. Sera were tested using multiplex liquid bead microarray antibody assays. We used logistic regression to assess the association between HPyV and HPV antibodies and lung cancer. RESULTS: There was no evidence of a positive association between levels of MCV, KIV, or WUV antibodies and incident lung cancer (p corrected \>0.10 for all trend tests; odds ratio (OR) range 0.72-1.09, p corrected \>0.10 for all). There was also no evidence for a positive association between HPV 16 or 18 infection and incident lung cancer (p corrected \≥0.10 for all trend tests; OR range 0.25-2.54, p\ \>\ 0.05 for all OR\ \>\ 1), but the number of persons with serologic evidence of these infections was small. CONCLUSIONS: Prior infection with any of several types of HPyV or HPV was not associated with subsequent diagnosis of lung cancer. Infection with these viruses likely does not influence a person\&$\#$39;s risk of lung cancer in Western smoking populations.

}, keywords = {Specimen Processing Core Facility}, issn = {1573-7225}, doi = {10.1016/j.whi.2015.08.006}, author = {Colombara, Danny V and Manhart, Lisa E and Carter, Joseph J and Hawes, Stephen E and Weiss, Noel S and Hughes, James P and Barnett, Matt J and Goodman, Gary E and Smith, Jennifer S and Qiao, You-Lin and Galloway, Denise A} }