@article{item\textunderscore3134886, title = {{Multi-analytic study of a probable case of fibrous dysplasia (FD) from certosa monumental cemetery (Bologna, Italy)}}, author = {Traversari, Mirko and Serrangeli, Maria Cristina and Catalano, Giulio and Petrella, Enrico and Piciucchi, Sara and Feletti, Francesco and Oxilia, Gregorio and Cristiani, Emanuela and Vazzana, Antonino and Sorrentino, Rita and Fanti, Sara De and Luiselli, Donata and Calcagnile, Lucio and Saragoni, Luca and Feeney, Robin N.M. and Gruppioni, Giorgio and Cilli, Elisabetta and Benazzi, Stefano}, language = {eng}, issn = {1879-9817}, doi = {10.1016/j.ijpp.2019.03.003}, publisher = {Elsevier}, address = {Amsterdam}, year = {2019}, date = {2019-06}, abstract = {{Objective To evaluate, via a multidisciplinary approach, a distinctive paleopathological condition believed to be fibrous dysplasia, found on a 19th/20th century skeleton from Certosa Monumental Cemetery, Bologna, Italy. Materials A skeletonized cranium and mandible recovered from an ossuary in 2014. Methods Pathological alterations were analysed by radiological examination, dental macrowear, histopathological and genetic analyses. Result The skeleton is believed to be an adult male. Differential diagnoses include Paget\textquotesingles disease, McCune-Albright syndrome, osteochondroma and osteosarcoma. The radiographic findings, along with the solitary nature of the lesions, are strong evidence for the diagnosis of fibrous dysplasia (FD). Genetic analysis further revealed a frequency of \~{}1 of mutant alleles with the R201C substitution, one of the post-zygotic activating mutation frequently associated with FD. Conclusions The multi-analytical method employed suggests a diagnosis of monostotic form of FD. The diagnostic design incorporates multiple lines of evidence, including macroscopic, histopathological, and genetic analyses. Significance Through the use of a multi-analytic approach, robust diagnoses can be offered. This case serves as one of the oldest examples of FD from an historical context. The genetic mutation detected, associated with FD, has not been previously reported in historical/ancient samples.}}, journal = {{International Journal of Paleopathology}}, volume = {25}, pages = {1--8}, }