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Mesenchymal stem cells (MSC) are considered to be a promising tool for cellular transplantations. This population of cells can find potential applications in multiple clinical disorders as a stimulant for regeneration and/or an immuno-modulator for the treated tissue. As adult stem cells, MSC allow performance of autologous transplantations. Therefore, it is crucial to understand the relationships between ageing and properties of this cell population. This review presents the current knowledge of morphological and functional changes in bone marrow-derived MSC during their ageing both in vivo and in vitro. This review discusses the mechanisms of cell ageing, such as telomere shortening or free radical effects on MSC, along with the susceptibility of cells to negative environmental conditions, depending on donor's age. The analyzed results often differ from each other, but the majority of in vitro studies indicate that the donor's age has an impact on mesenchymal cell properties. The data suggest that cells derived from aged individuals display a lower therapeutic potential then the cells isolated from young organisms. Very few clinical trials conducted in humans do not allow drawing conclusions about the relationship between the donor's age and the transplantation outcome.

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PBK Postępby biologi komórki