TY - JOUR T1 - Evidence for a Tumor Suppressor Role for the <em>Large Tumor Suppressor</em> Genes <em>LATS1</em> and <em>LATS2</em> in Human Cancer JF - Genetics JO - Genetics SP - 1193 LP - 1196 DO - 10.1534/genetics.113.156372 VL - 195 IS - 3 AU - Yu, Tian AU - Bachman, John AU - Lai, Zhi-Chun Y1 - 2013/11/01 UR - http://www.genetics.org/content/195/3/1193.abstract N2 - The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations. ER -