doxepin in sleep disorder: low dosage is key History: I am a hypothyroid patient who is still working at getting to the right T3/T4 dosage. Hypothyroidism is the genesis of my sleep disorder. I have used doxepin intermittently for over 10 years, in doses ranging from 5mg to 125mg. And, I have used a variety of other medications for sleep disorder. The primary disadvantage of doxepin is next-day hangover. However, I've found that, in my case, this effect is minimal if the dosage is kept low, in the area of 5mg to 7.5mg nightly. If I do this, I get a good sleep effect, and the cost is very minimal. The only way I can get this low dosage, is to empty a 10mg cap and divide the contents. Note that Somaxon Pharmaceuticals ( is working on marketing low-dose doxepin (1mg, 3mg, 6mg) under patent name SILENOR. Their research has found that it works for pure sleep disorder at these low doses. Silenor will probably be considerably more expensive than generic doxepin, but the hassle of compounding a dose less than 10mg from generic 10mg capsules, may make the cost worth it. I'm not sure why doxepin isn't offered in tablets; that would be the ideal form for finding the right low dose.