TY - JOUR T1 - ADverse outcomes associated with use of proton pump inhibitors and clopidogrel AU - Hayes S Y1 - 2009/07/01 N1 - 10.1001/jama.2009.899 JO - JAMA SP - 29 EP - 31 VL - 302 IS - 1 N2 - One major risk not reported in the baseline characteristics or identified in the article is tobacco use status. It is estimated that 11% of total global cardiac deaths are related to cigarette smoking.2 A significant difference in smoking rates between the cohorts could explain the observed difference in outcomes. Additionally, those individuals who smoke might be more likely to have a PPI prescribed to counter risk factors for peptic ulcer disease in users of clopidogrel and aspirin. SN - 0098-7484 M3 - doi: 10.1001/jama.2009.899 UR - http://dx.doi.org/10.1001/jama.2009.899 ER -