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Histone cluster 1, H2be
Protein HIST1H2BE PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST1H2BE ; H2B.h; H2B/h; H2BFH; dJ221C16.8
External IDs OMIM602805 MGI2448383 HomoloGene130120 GeneCards: HIST1H2BE Gene
Species Human Mouse
Entrez 8344 68024
Ensembl ENSG00000168242 ENSMUSG00000018102
UniProt P62807 Q6ZWY9
RefSeq (mRNA) NM_003523 NM_023422
RefSeq (protein) NP_003514 NP_075911
Location (UCSC) Chr 6:
26.12 – 26.12 Mb
Chr 13:
23.57 – 23.57 Mb
PubMed search [1] [2]

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BE gene.[1][2][3]



The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]


  1. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ a b "Entrez Gene: HIST1H2BE histone cluster 1, H2be". 

Further reading[edit]