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Athena Andreadis, Ph.D.

Athena Andreadis, Ph.D.

Posted: May 24, 2010 08:29 PM

Venter's Celebrity Bacterium: The Faucet Drip That Would Be a Monsoon

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Last week, bio-enterpreneur icon Craig Venter burst into the limelight yet again by announcing that a team under his direction inserted a chemically synthesized genome into Mycoplasma and succeeded in getting the resulting bacterium to propagate. The work duly appeared in Science and the predictable shouting ensued, from fears that humans are "playing God" to hails of "artificial life".

Several important issues got lost in the din. Let's leave the obvious potential objections aside - after all, humans started futzing the moment their frontal cortex became prominent and the consequences of this, intended and not, have decisively affected earth and all life on it. Instead, let's examine the clothes of this emperor closer up. To stick with the metaphor, Venter's latest is like exactly reproducing a large cloak onto a new piece of fabric identical to that of the original. It's not like creating a new garment or even cutting and pasting from previous garments to make a quilt, crazy or otherwise.

The Venter work is not a discovery, let alone a paradigm shift. It's a technological advance and even then not of technique but only of scale. The experiment is merely an extension of a well-known principle that every biology lab uses routinely: namely, that bacterial genomes can be modified almost at will (barring a few indispensable regions) and in such ways as to turn the bacteria into potent mini-factories for specific proteins. The Venter bacterium is actually pedestrian because it carries an exact duplicate of a naturally occurring genome. Its only artificial aspects are the molecular "flags" that its makers included in the synthesis to mark the artificial genome for further tracking - standard operating procedure in all such modifications.



In short, the Venter endeavor was expensive, glitzy - and banal. My advice to bioethicists is to save their energy for truly fearsome items, such as recombinant bacteria or viruses that may arise from species pushed together by abrupt dislocations of habitats (and for the inevitable push for a broad research-suffocating patent from this work). I've done far more "dangerous" work in my near-constant cloning than this sheep attempting to pass as a wolf... nay, a lion.

Note: This article is also on the author's blog, with two images that tell the whole story succinctly and far more eloquently than words.