Familial exudative vitreoretinopathy

Familial exudative vitreoretinopathy is also called FEVR, Criswick-Schepens syndrome (former name for the autosomal dominant form of the disease) or OMIM 133780.

Familial exudative vitreoretinopathy (FEVR) is an inherited eye disorder characterized by premature arrest of the vascularization of the peripheral retina and significant phenotypic and genotypic variability. The disease affects full-term infants with severity ranging from absence of visual symptoms to total blindness. FEVR belongs to the group of vitreoretinal dystrophies.

FEVR was first described in 1969 by Criswick and Schepens in patients exhibiting clinical manifestations similar to those of retinopathy of prematurity (ROP) but without history of prematurity or oxygen supplementation.