


Pronunciation: glas DEG ib

Brand: Daurismo

What is the most important information I should know about glasdegib?

Glasdegib can cause severe birth defects or death of a baby if the mother or the father is taking this medicine at the time of conception or during pregnancy. Both men and women should use effective birth control to prevent pregnancy while using this medicine and for at least 30 days after your last dose.

What is glasdegib?

Glasdegib is used in combination with cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Glasdegib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking glasdegib?


  • If you are a woman who is able to get pregnant, you may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 30 days after your last dose.
  • If you are a man, use condoms when having sex with a woman who is able to get pregnant, even if you have had a vasectomy. Keep using condoms for at least 30 days after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using glasdegib.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because glasdegib can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 30 days after your last dose.

Tell your doctor if you have ever had:

  • heart problems;

How should I take glasdegib?


Glasdegib is given in a 28-day treatment cycle, usually for a total of 6 cycles. Glasdegib is taken by mouth, and cytarabine is given as an injection under your skin. Your doctor will determine how long to treat you with this medicine.



If you vomit shortly after taking glasdegib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.


Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time or use more than one dose in a 12-hour period.

What happens if I overdose?


Overdose symptoms may include tiredness, nausea, vomiting, dizziness, feeling like you might pass out, thirst, and little or no urination.

What should I avoid while taking glasdegib?

You must not donate blood or sperm while you are using glasdegib, and for at least 30 days after your last dose. If donated blood containing glasdegib is given to a pregnant woman, it could cause birth defects.

What are the possible side effects of glasdegib?


Call your doctor at once if you have:

  • irregular or fast heartbeats, shortness of breath, and sudden dizziness (like you might pass out);


Common side effects may include:

  • bleeding, low platelet count;
  • fever, low blood cell counts;
  • mouth sores, changes in your sense of taste;
  • loss of appetite, constipation, nausea;
  • rash;
  • muscle pain;
  • swelling in your arms or legs;
  • feeling tired; or
  • trouble breathing.


What other drugs will affect glasdegib?




Where can I get more information?

Your pharmacist can provide more information about glasdegib.



Copyright 1996-2021 Cerner Multum, Inc. Version: 2.01. Revision date: 4/28/2020.
