Association between amyloid-beta and neuropathology in dementia with Lewy bodies


  • Lower 11C-Pittsburgh compound B (PiB) uptake is associated with Lewy body disease (LBD) without Alzheimer’s disease (AD) pathology, and the severity of amyloid-beta (Aβ) pathology is the primary reason for elevated PiB uptake.

Why this matters

  • Aβ pathology is common in people with AD, LBD, and dementia with Lewy bodies (DLB), and PiB is the most studied positron emission tomography (PET) ligand for Aβ.

  • Understanding Aβ PET findings in LBD and DLB is necessary to effectively use the biomarker of AD pathology in patients with probable DLB.