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Histone cluster 3, H3
Protein HIST3H3 PDB 1aoi.png
PDB rendering based on 1aoi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HIST3H3 ; H3.4; H3/g; H3FT; H3t
External IDs OMIM602820 HomoloGene133212 GeneCards: HIST3H3 Gene
RNA expression pattern
PBB GE HIST3H3 208572 at tn.png
More reference expression data
Species Human Mouse
Entrez 8290 623365
Ensembl ENSG00000168148 ENSMUSG00000062417
UniProt Q16695 P68433
RefSeq (mRNA) NM_003493 NM_145073.2
RefSeq (protein) NP_003484 NP_659539.1
Location (UCSC) Chr 1:
228.61 – 228.61 Mb
Chr 13:
21.81 – 21.81 Mb
PubMed search [1] [2]

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.[1][2]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.[3]


  1. ^ Albig W, Ebentheuer J, Klobeck G, Kunz J, Doenecke D (Dec 1996). "A solitary human H3 histone gene on chromosome 1". Hum Genet 97 (4): 486–91. doi:10.1007/BF02267072. PMID 8834248. 
  2. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966. 
  3. ^ "Entrez Gene: HIST3H3 histone cluster 3, H3". 

Further reading[edit]