Use Caution I've had grand mal seizures since I was about 15, so for about 5 years now. Topomax is the 5th med I've been stuck on. Talk about appetite loss! I've lost 15 lbs in the last 2 weeks. Did you guys know they're testing this stuff as a weight loss drug?? Besides the lack of eating (if you eat at all) the worst side effects I can see are your hands, feet, and face constantly falling asleep and the numbness and tingling. It's not as bad as it was but I still can't seem to get rid of it...more annoying than anything. But if I can drop just a few more pounds I'm not gonna complain. Just be extremely careful that you don't end up anorexic...because on this stuff you definitely wouldn't be hard.