Oddity #1



The Ar-SO2CH2CH2Cl


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12 Comments on “Oddity #1”

  1. Milo Says:

    I had a 2,6- diaryl pyridine once that showed a singlet (3H) for the pyridine protons. I blamed it on one of those once-in-a-blue-moon coincident chemical shift events. Changing to d6 benzene caused them to look like the standard peaks I would expect.

  2. weirdo Says:

    Milo’s got it right. The most simplistic explanation is the correct one: in CDCl3 the protons have the same chemical shift, thus no splitting and a singlet. Different solvent, different pattern. Pretty common, actually.

  3. SBC Says:

    I would have guessed they were around 3 ppm

  4. Watson Says:

    I have experienced this effect with the preparation of Leighton’s crotyl/allyl silation reagent. See Angew. Chem. Int. Ed. 2003 42(8) 946 for the prep, J. Organomet. Chem. 1998 v. 567 p. 199 for spectral data on the intermediate diimine. If anybody can explain what’s up with TMS-ethanol’s spectrum (http://www.sigmaaldrich.com/spectra/fnmr/FNMR003501.PDF), I would love to know why it looks so whacked.

  5. milo Says:


    Have you ever checked out a detailed spectrum of THF? You’ll find peak shapes that are similar to TMS-EtOH. Although I cannot give a good explanation. I can give a good hand hand waving one, but that is not really scientific :-)

  6. Watson Says:

    It appears that 3,3-dimethylbutanol has a similar effect going on in one CH2. It must be a steric thing. Mercapto Ethanol, or Iodoethanol are just triplets, or dt depending on the dryness. SEMCl also the same effect.

  7. Carbazole Says:

    Yeah, 2-nitroethanol shows a singlet for the four methylene protons as well. Never changed solvents to make sure, but I wasn’t bothered by it enough.

  8. Darksyde Says:

    Throw it on the 900 MHz to resolve those two chemical shifts.

  9. tom bartlett Says:

    I had a 4-chloroarylsulfone where the 4 aryl protons were equivalent in CDCl3 at 400 MHz……

  10. K.C. Says:

    My suggestion is do a variable temperature NMR to see whether there is any dynamic process occurring in CDCl3.

  11. nadia Says:

    I have an ‘out-there’ suggestion. The loss of DCl from your CDCl3 (often happens!) would result in a reactive carbene which could react with the chloro-alkane resulting in the loss of HCl and if your CDCl3 was a bit wet a sulphonic acid, and finally a dichloro-cyclopropane. The cyclopropane meets all of the spectroscopic requirements. Maybe a DEPT can tell you something?

  12. John Lewis Says:


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