RT Journal A1 Meyerhardt JA, Giovannucci EL, Ogino S, et al T1 PHysical activity and male colorectal cancer survival JF Archives of Internal Medicine JO Archives of Internal Medicine YR 2009 FD December 14 VO 169 IS 22 SP 2102 OP 2108 DO 10.1001/archinternmed.2009.412 UL http://dx.doi.org/10.1001/archinternmed.2009.412 AB Background  Although physically active individuals have a lower risk of developing colorectal cancer, few studies have examined whether exercise benefits colorectal cancer survivors.Methods  Derived from the Health Professionals Follow-up Study, we studied colorectal cancer–specific and overall mortality in a cohort of 668 men with a history of stage I to stage III colorectal cancer according to predefined physical activity categories after diagnosis. To minimize bias by occult recurrences, we excluded men who died within 6 months of their postdiagnosis physical activity assessment.Results  In a cohort of men with colorectal cancer and no apparent metastases at diagnosis, 50.4% exercised at least 18 metabolic equivalent task (MET) hours per week. Increased physical activity was significantly associated with improved colorectal cancer–specific mortality (P = .002 for trend) and overall mortality (P < .001 for trend). Men who engaged in more than 27 MET hours per week of physical activity had an adjusted hazard ratio for colorectal cancer–specific mortality of 0.47 (95% confidence interval, 0.24-0.92) compared with men who engaged in 3 or less MET hours per week of physical activity. The apparent benefit of physical activity was seen regardless of age, disease stage, body mass index, diagnosis year, tumor location, and prediagnosis physical activity.Conclusion  In a large cohort of men with a history of nonmetastatic colorectal cancer, more physical activity was associated with a lower risk of colorectal cancer–specific and overall mortality.