

The tiny compounds could eventually help Paula Deen  (Source:

This study was published in Nature.

Source: Science Daily

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By JediJeb on 3/30/2012 3:39:41 PM , Rating: 3
Increase in oxygen consumption with decrease in overall activity, makes me wonder if their body temperature remained stable or increased? Oxygen metabolism is in a chemical sense "burning" a carbon based fuel, then if that energy being generated from the burning is not being converted into some type of physical action, then it should be converting into heat.

I am glad they did show a lowering of blood glucose and not just make the assumption that lowering body fat automatically lowers blood sugar, since that is not always the case. There are factors other than just body fat that block the efficient use of insulin to transport glucose into the cells, which is the main cause of high blood glucose levels. B Vitamin levels, physical activity, and other blood chemistry factors all contribute to diabetes. Also you have the fact that diabetes can cause weight gain, but the opposite is also true in that excessive weight gain can cause reduced insulin tolerance. Once you study biochemistry you learn that a living body is one of the most complex balancing acts chemically that exists and that we still know only a small amount of what actually takes place inside the body.

By geddarkstorm on 3/30/2012 5:52:09 PM , Rating: 2
Their data showed both significantly lowered body fat and lower blood sugar in tandem. The two are generally linked, though as you said, not always. There are other ways to short the system.

Most likely these upregulated clocks are stimulating a large release of some hormone that's activating brown fat production and higher metabolism (the type that keeps us warm, especially as we sleep), so I would expect as you said that body temperature probably rose some. Could also be a lot of the sugar and fat was simply converted into waste products, and not directly burned.

Be very interesting to see how this develops. To think the circadian system had such a potent phenotype over fat and glucose levels is profound.

What people are starting to learn is that calories are not a number game to biological systems. Counting calories means nothing except at the extreme ends of the range. For instance, mice on a 40% calorie restriction diet actually take in more calories per pound of body weight versus mice on a normal diet--and yet they are slimmer, fitter, live significantly longer and healthier. It's a paradox.

The key is that chemical balancing act. There are so many concentration dependent and -gradients of concentrations- dependent activities and gene regulations in our bodies, it's mind boggling. But if we can figure out how to slip the body's gene expression profiles into calorie restriction mode, that would do wonders for people's health regardless of diet.

By JediJeb on 3/31/2012 10:43:19 PM , Rating: 1
Yes it is amazing how complex the human body is. I also remember my great uncle who was about 5'7" and weighed maybe 100 pounds, walked 3 to 5 miles most days, worked on a farm most of his life, ate like a bird and still had Type II diabetes, and yet most of the commentators in the other thread know so much about biochemistry they solve the problem with "Duh, just eat less and you will be healthy". If only it was so simple.


By gcappio on 3/31/2012 7:39:46 AM , Rating: 2
You are the only one speaking about INSULINE...

that's the key to: gaining/losing weight, diabetes, blood pressure, cholesterol...

as I learnt from this EXPLORER

and this was me

