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Junctional adhesion molecule 2
Symbols JAM2 ; C21orf43; CD322; JAM-B; JAMB; PRO245; VE-JAM; VEJAM
External IDs OMIM606870 MGI1933820 HomoloGene10929 GeneCards: JAM2 Gene
RNA expression pattern
PBB GE JAM2 219213 at tn.png
More reference expression data
Species Human Mouse
Entrez 58494 67374
Ensembl ENSG00000154721 ENSMUSG00000053062
UniProt P57087 Q9JI59
RefSeq (mRNA) NM_001270407 NM_023844
RefSeq (protein) NP_001257336 NP_076333
Location (UCSC) Chr 21:
27.01 – 27.09 Mb
Chr 16:
84.77 – 84.83 Mb
PubMed search [1] [2]

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.[1][2][3] JAM2 has also been designated as CD322 (cluster of differentiation 322).



It is purported to promote lymphocyte transendothelial migration.[4] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PAR-3, together with JAM3.[5]


JAM2 has been shown to interact with PARD3.[5]

It also interacts with α4β1.[6]


  1. ^ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000). "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells". J Biol Chem 275 (25): 19139–45. doi:10.1074/jbc.M003189200. PMID 10779521. 
  2. ^ Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000). "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions". J Biol Chem 275 (44): 34750–6. doi:10.1074/jbc.M002718200. PMID 10945976. 
  3. ^ a b "Entrez Gene: JAM2 junctional adhesion molecule 2". 
  4. ^ Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002). "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration". Blood 100 (7): 2479–86. doi:10.1182/blood-2001-11-0098. PMID 12239159. 
  5. ^ a b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell. Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056. 
  6. ^ Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135. 

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