The Pediatric Epilepsy Research Consortium (PERC) is a group of US pediatric epilepsy centers, researchers and professionals in field of epilepsy whose goal is to provide a network and infrastructure to facilitate collegial, collaborative practice-changing research that will provide answers needed to improve the care of children with epilepsy. Many severe childhood epilepsies are relatively rare, and it is only through a large collaborative effort involving multiple centers that progress in their treatment and outcomes will be made.