Suehirotake (schizophyllum commune), commonly known as the “Split-Fold Mushroom”, is best known for its polysaccharide structure, schizophyllan (SPG), a polysaccharides commonly used to derive pharmaceuticals.  SPG functions by activating macrophages, stimulating T cells and natural killer (NK) cells of the immune system (1) .  Furthermore, recent research also discovered an enzyme, ScFz, which may supplement circulatory health(2) in animal models.

Active Constituents:

Suehirotake consists of schizophyllan (SPG) which is a polysaccharide-protein complex which may help to support liver (3) and immune health (4).  The intracellular enzymes, ScFz, may assist in the fibrin degradation process which may help support a health blood pressure and cardiovascular wellness.(5)

Pharmacological and Clinical Research: Original Research on Suehirotake mushroom

1. Liu et al., Immunomodulation and anti-cancer activity of polysaccharide-protein complexes., Curr Med Chem. 2000 Jul;7(7):715-29.
2. Chen et al., Protease purified from Schizophyllum commune culture broth digests fibrins without activating plasminogen., Am J Chin Med. 2010;38(6):1223-31.
3. Flynn et al., A potent specific inhibitor of 6-phosphogluconate dehydrogenase of Cryptococcus neoformans and of certain other fungal enzymes., Mycopathologia. 1993 Sep;123(3):155-8.
4. Fujiwara et al., Cooperative role of T lymphocytes and macrophages in anti-tumor activity of mice pretreated with schizophyllan (SPG)., Jpn J Exp Med. 1982 Apr;52(2):59-65.
5. Wasser SP, Weis AL., Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective., Crit Rev Immunol. 1999;19(1):65-96.