Savory additive

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Last seen on: NY Times Crossword 8 Nov 19, Friday

Random information on the term “MSG”:

Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) on a daily basis over a lifetime without an appreciable health risk. ADIs are expressed usually in milligrams (of the substance) per kilograms of body weight per day.

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This concept was first introduced in 1961 by the Council of Europe and later, the Joint FAO/WHO Expert Committee on Food Additives (JECFA), a committee maintained by two United Nations bodies: the Food and Agriculture Organization (FAO) and the World Health Organization (WHO).

An ADI value is based on current research, with long-term studies on animals and observations of humans. First, a no-observed-adverse-effect level (NOAEL), the amount of a substance that shows no toxic effects, is determined. Usually the studies are performed with several doses including high doses. In the case of several studies on different effects, the lowest NOAEL is usually taken. Then, the NOAEL (or another point of departure such as a benchmark dose level (BMDL)) is divided by a safety factor, conventionally 100, to account for the differences between test animals and humans (factor of 10) and possible differences in sensitivity between humans (another factor of 10). safety factors with values other than 100 may be used if information on uncertainty about the value of the point of departure (NOAEL or BMDL) justify it. For instance, if the ADI is based on data from humans the safety factor is usually 10 instead of 100. The ADI is usually given in mg per kg body weight.

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