PT - JOURNAL ARTICLE AU - Parys, Jan B. TI - The IP<sub>3</sub> Receptor as a Hub for Bcl-2 Family Proteins in Cell Death Control and Beyond AID - 10.1126/scisignal.2005093 DP - 2014 Feb 11 TA - Science Signaling PG - pe4--pe4 VI - 7 IP - 312 4099 - 4100 - SO - Sci. Signal.2014 Feb 11; 7 AB - Bcl-2 family proteins generally have a proapoptotic or antiapoptotic role. In addition to their known roles at the mitochondria, Bcl-2 family proteins also influence signaling at the endoplasmic reticulum by binding to the inositol 1,4,5-trisphosphate receptor (IP3R), the most ubiquitous intracellular Ca2+ channel. Surprisingly, multiple Bcl-2 family proteins target different sites on the IP3R to elicit various effects on IP3R function, which suggests that the IP3R is an important hub for Bcl-2 family proteins in various physiological settings.