TY - JOUR T1 - Association of Pancreatic Cancer Susceptibility Variants with Risk of Breast Cancer in Women of European and African Ancestry JF - Cancer Epidemiology Biomarkers &amp; Prevention JO - Cancer Epidemiol Biomarkers Prev SP - 116 LP - 118 DO - 10.1158/1055-9965.EPI-17-0755 VL - 27 IS - 1 AU - Wang, Shengfeng AU - Zheng, Yonglan AU - Ogundiran, Temidayo O. AU - Ojengbede, Oladosu AU - Zheng, Wei AU - Nathanson, Katherine L. AU - Nemesure, Barbara AU - Ambs, Stefan AU - Olopade, Olufunmilayo I. AU - Huo, Dezheng Y1 - 2018/01/01 UR - http://cebp.aacrjournals.org/content/27/1/116.abstract N2 - Background: Pancreatic cancer mutation signatures closely resemble breast cancer, suggesting that both cancers may have common predisposition mechanisms that may include commonly inherited SNPs.Methods: We examined 23 genetic variants known to be associated with pancreatic cancer as breast cancer risk factors in the Root genome-wide association study (GWAS; 1,657 cases and 2,029 controls of African diaspora) and GAME-ON/DRIVE GWAS (16,003 cases and 41,335 controls of European ancestry).Results: None of the pancreatic cancer susceptibility variants were individually associated with breast cancer risk after adjustment for multiple testing (at α = 0.002) in the two populations. In Root GWAS, a change by one SD in the polygenic risk score (PRS) was not significantly associated with breast cancer. In addition, we did not observe a trend in the relationship between PRS percentiles and breast cancer risk.Conclusions: The association between reported pancreatic cancer genetic susceptibility variants and breast cancer development in women of African or European ancestry is likely weak, if it does exist.Impact: Known GWAS-derived susceptibility variants of pancreatic cancer do not explain its shared genetic etiology with breast cancer. Cancer Epidemiol Biomarkers Prev; 27(1); 116–8. ©2017 AACR. ER -