@article {Vinsonec126, author = {Vinson, Valda}, title = {Complement Receptor Complex Structure}, volume = {4}, number = {171}, pages = {ec126--ec126}, year = {2011}, doi = {10.1126/scisignal.4171ec126}, publisher = {Science Signaling}, abstract = {Complement receptor 2 (CR2), found in B cells and follicular dendritic cells, binds to a ligand, C3d, which is bound to antigen. The antigen simultaneously binds to the B cell antigen recognition complex such that this coligation enhances the antibody response. A previously published crystal structure of the CR2:C3d complex possibly represented a nonphysiological interaction. Hence, van den Elsen and Isenman report a structure in which the molecular details of the interface are more consistent with biochemical data, supporting physiological relevance and providing a foundation for rational design of therapeutics against autoreactive B cells. J. M. H. van den Elsen, D. E. Isenman, A crystal structure of the complex between human complement receptor 2 and its ligand C3d. Science 332, 608{\textendash}611 (2011). [Abstract] [Full Text]}, issn = {1945-0877}, URL = {https://stke.sciencemag.org/content/4/171/ec126}, eprint = {https://stke.sciencemag.org/content/4/171/ec126}, journal = {Science Signaling} }