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Ambenonium Brand names, Ambenonium Analogs

Ambenonium Brand Names Mixture

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Ambenonium Chemical_Formula


Ambenonium RX_link

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Ambenonium fda sheet

Ambenonium msds (material safety sheet)

Ambenonium MSDS

Ambenonium Synthesis Reference

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Ambenonium Molecular Weight

537.564 g/mol

Ambenonium Melting Point

196-199 oC

Ambenonium H2O Solubility


Ambenonium State


Ambenonium LogP

No information avaliable

Ambenonium Dosage Forms

Tablet (10 mg)

Ambenonium Indication


Ambenonium Pharmacology

Ambenonium, similar to pyridostigmine and neostigmine, is used for the treatment of muscle weakness and fatigue in people with myasthenia gravis. It is postulated to exert its therapeutic effect by enhancing cholinergic function by inhibiting the hydrolysis of acetylcholine by acetylcholinesterase. Increased levels of acetylcholine has peripheral effects, as acetylcholine is also used in the brain, where it tends to cause excitatory actions. The glands that receive impulses from the parasympathetic part of the autonomic nervous system are also stimulated in the same way. This is why an increase in acetylcholine causes a decreased heart rate and increased production of saliva. Ambenonium is used less commonly than neostigmine or pyridostigmine but may be preferred in patients hypersensitive to the bromide ion. Ambenonium produces fewer muscarinic side effects than neostigmine, but more than pyridostigmine.

Ambenonium Absorption

Oral - poorly absorbed from the gastrointestinal tract.

Ambenonium side effects and Toxicity

LD50=150±44 mg/kg (orally in mice). Symptoms of overdose include muscle twitching, weakness and paralysis of voluntary muscles including the tongue, shoulders, neck and arms, blood pressure increase (with or without a slowing of heart rate), a sensation of internal trembling, severe anxiety, and panic. Death may occur rapidly if untreated.

Ambenonium Patient Information

Ambenonium Organisms Affected

Humans and other mammals