Artesunate and Amodiaquine Tablet Formulation

Artesunate and amodiaquine are incompatible, wherein severe degradation of the drugs in presence of each other. The central hypothesis for formulation development was based on the sensitivity of artesunate to the acidity brought by HCl molecules present in the amodiaquine salt that is enhanced by temperature and humidity. Due to the chemical incompatibility of the two drugs which causes mutual decomposition and leads to stability problems. This poses a challenge to the formulating pharmacist while presenting the combination of the two drugs in a single dosage form.

The objective of formulating a single dosage form is improved patient compliance resulting in decreased possibility of recurrence or developing resistance.