N-acylneuraminate-9-phosphate synthase

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N-acylneuraminate-9-phosphate synthase
EC number2.5.1.57
CAS number9031-58-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-acylneuraminate-9-phosphate synthase (EC is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O N-acylneuraminate 9-phosphate + phosphate

The 3 substrates of this enzyme are phosphoenolpyruvate, N-acyl-D-mannosamine 6-phosphate, and H2O, whereas its two products are N-acylneuraminate 9-phosphate and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase. Other names in common use include N-acetylneuraminate 9-phosphate lyase, N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase, N-acetylneuraminate 9-phosphate synthetase, N-acylneuraminate-9-phosphate pyruvate-lyase, (pyruvate-phosphorylating), and sialic acid 9-phosphate synthetase. This enzyme participates in aminosugars metabolism.

Structural studies[edit]



  • Roseman S, Jourdian GW, Watson D, Rood R (1961). "Enzymatic synthesis of sialic acid 9-phosphates". Proc. Natl. Acad. Sci. USA. 47 (7): 958–961. doi:10.1073/pnas.47.7.958. PMC 221309.
  • Watson DR, Jourdian GW, Roseman S (1966). "The sialic acids. 8. Sialic acid 9-phosphate synthetase". J. Biol. Chem. 241 (23): 5627–36. PMID 5928202.
  • Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K (2000). "Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity". Biochem. Biophys. Res. Commun. 273 (2): 642–8. doi:10.1006/bbrc.2000.2983. PMID 10873658.