TY - JOUR T1 - Altered functional connectivity during speech perception in congenital amusia JF - bioRxiv DO - 10.1101/834366 SP - 834366 AU - Jasmin, Kyle AU - Dick, Fred AU - Stewart, Lauren AU - Tierney, Adam Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/11/20/834366.abstract N2 - Individuals with congenital amusia have a lifelong history of unreliable pitch processing. Accordingly, they downweight pitch cues during speech perception (even large, obvious ones), and instead rely on other dimensions like duration. We investigated the neural basis for this strategy. Using fMRI, individuals with amusia and controls (N=30) were scanned while they used pitch and duration cues to match auditory and visual sentences. A data-driven analysis procedure identified four ‘seed’ regions showing large Control &gt; Amusic functional connectivity differences in lateral prefrontal cortex, which were examined with respect to the rest of the brain. Prominent decreases in functional connectivity were detected in the amusia group, between left prefrontal language-related regions (inferior and middle frontal gyrus/DLPFC) and right hemisphere pitch-related regions (auditory and anterior insular cortex). Our results suggest that individuals compensate for differences in the reliability of perceptual dimensions by regulating functional connectivity between task-relevant frontal and perceptual regions. ER -