FACT complex subunit SPT16 - Q9Y5B9 (SP16H_HUMAN)


Protein Feature View of PDB entries mapped to a UniProtKB sequence  

  • Number of PDB entries for Q9Y5B9: 6
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). UniProt
Pathway Maps
      ESCHER  BiGG
Subunit Structure
(Microbial infection) Interacts with Herpes simplex virus 1 (HHV-1) protein ICP22; this interaction relocalizes the FACT complex to viral genomes in infected cells. UniProt
The C-terminal Glu-rich acidic region is essential for FACT activity. UniProt
Data origin/color codes
The vertical color bar on the left side indicates data provenance.
Data in green originates from UniProtKB  
Data in purple originates from Phosphosite  .
  • Red: potentially disorderd region
  • Blue: probably ordered region.
  • Red: hydrophobic
  • Blue: hydrophilic.
Data in blue originates from PDB
Validation Track


