Paget's cell

Pag·et's cell

Any of the large, epithelial cells with clear cytoplasm associated with Paget's disease of the breast or an apocrine gland cancer of the skin.
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HER2 molecular subtype is a dominant subtype of mammary Paget's cells: an immunohistochemical study [published correction appears in Histopathology.
Histopathology of areolar region showed characteristic Paget's cells in clusters in basal epidermis and in single's in upper epidermis.
Figure 5: Paget's cells in the epidermis- large cells in cluster and singles with clear cytoplasm and hyperchromatic nuclei.
We defined EMPD by the typical clinical features and histological characteristics such as Paget's cells, defined as rounded cells that are devoid of intracellular bridges and have large nuclei and ample cytoplasm, seen in the epidermis.
Suprapubic region, Paget's cells, cytokeratin 7, carcinoembryonic antigen.
Skin biopsy from the lesion with hematoxylin and eosin staining showed presence of fair number of round to oval large cells having large, prominent nuclei and ample clear cytoplasm infiltrating throughout the epidermis, indicative of Paget's cells. The basal layer was flattened.
The current theories on the origin of Paget's cells are: a) an adenocarcinoma in pluripotent epidermal cells, b) an underlying adenocarcinoma of apocrine or eccrine glands or c) the multicentric effect of a carcinogenic stimulus in the epidermis.