RT Journal Article SR Electronic T1 PTEN: An Intercellular Peacekeeper? JF Science Signaling JO Sci. Signal. FD American Association for the Advancement of Science SP pe50 OP pe50 DO 10.1126/scisignal.2003685 VO 5 IS 250 A1 Leslie, Nick R. YR 2012 UL http://stke.sciencemag.org/content/5/250/pe50.abstract AB It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor suppression, showing that PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.