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    Medicate safer. Reduce your comedown.


    Addysafe.org is an Adderall and Ritalin harm reduction and safety guide.

  • Note

    This advice applies if you are determined to take stimulants. The safest option is likely to not use stimulants, the second safest option is to use stimulants as responsibly as possible, and the most dangerous option is to use stimulants irresponsibly.

    Addysafe is concerned with public health and the safety of people. We do not endorse the acquisition and use of illegal drugs. If you’re likely to use stimulants anyway due to a prescription, please do your research.


    Recent Updates

    Added supplement stack recommendations.



    Memantine (Rx) can work well to reduce tolerance

    Selegiline (Rx)

    L-Tyrosine (after) (Helps replenish dopamine, which will help even out the highs and lows)

    Omega 3 Fatty Acids (before/whenever) (General brain health)

    Vitamin D (morning) (Mood)

    Inositol (Reduces nail biting, hair pulling and other obsessive symptoms)





    Source Information

    Research compilation.


    Take these supplements to increase the effects of the Adderall and reduce the come down.


    10-30 minutes before.


    Magnesium Glycinate: 1x200mg Pill (2,000mg magnesium glycinate, which is equivalent to 200mg elemental Mg)


    (Use the linked brand. Many brands or formulations of magnesium have low absorption rates)

    R-ALA: 1x100mg (Reduces neurotoxicity)

    ALCAR: 1x500mg (Reduces neurotoxicity)

    L-Theanine: 1x200mg (Helps prevent tolerance buildup, however more for reduction of anxiety/paranoia/irritability)

    CoQ10: 1x100mg ("Extremely long half life antioxidant, various beneficial effects on mitochondrial function")

    1-2x Tums, or 1/2 teaspoon of baking soda mixed in a glass of water (Potentiates Adderall due to reduction in stomach acidity)



    Sugary snacks. Aim to eat one every ~30 minutes. (Helps maintain blood glucose levels - you'll feel less tired and happier)


    Seriously - it's mentioned below, but EAT AND DRINK!

    Optionally: Dose one of each magnesium, R-ALA and ALCAR during.


    To help you: Go to sleep easier and feel better tomorrow.


    R-ALA: 1x100mg (Reduces neurotoxicity)
    ALCAR: 1x500mg (Reduces neurotoxicity)


    Vitamin C: 1000-2000mg (The acidity of vitamin-c will help reduce the effects of Adderall, making it easier to sleep)

    Melatonin: 5-10mg roughly 30 minutes before bed (Keep in mind we are using a higher dose here for it's antioxidant properties. Normal dosages should be .5mg to 1mg.)


    If you are on a significant Adderall spree, consider replacing a re-dose of Adderall with Caffeine.


    Tips for staying healthy during your stim session.



    • Don't forget to stay hydrated
    • Don't drink acidic drinks until you are ready for the Adderall to wear off. 
    • Even if you don't feel like it, EAT. Things like granola bars, glasses of milk, nuts, beef jerky etc are great at providing calories.
    • Avoid overheating: Overheating can increase neurotoxicity



    How to not make your friends hate you.


    • Adderall can make not brushing your teeth or not showering feel okay. Keep up your damn hygiene!

    • "You're going to have to learn to be okay with knowing you're right in an argument, and keeping your mouth shut. It's a huge problem because you end up fighting tooth and nail about something you don't even care about, and alienating those close to you. It's kinda like that meme from the Big Lebowski; You're not wrong, you're just an asshole."

    • Don't overanalyze people. They are probably not doing something malicious - Adderall can cause paranoia.
    • Don't be too damn energetic on Monday morning! Everyone else is struggling to get out of bed!



    Or, lack thereof.


    Please, don't pull all nighters. 40 year old you will be pissed off.



    Vitamin C or some acidic juice to blunt the Adderall absorption


    25mg of Diphenhydramine will put you to sleep quickly, however tolerance to this builds quickly so don't use this often.


    How to maximize the study benefits of Adderall.

    Set timers to switch between tasks. Adderall can make it difficult to remember to change tasks.

    Write down all of the work you need to do, before you take the Adderall

    "You will have a lot of energy to try and better yourself. Don't try to do so all at once or none of it will stick in the long run. As soon as you run out of energy it will fall apart. Instead, try to make small and modest permeant changes to your lifestyle and things will slowly come together. This is a good idea, sims or no."


    Use the lowest doses possible, and use as infrequently as possible.


    "Most of the painful side effects of stims are a result of intense downregulation of dopamine receptors and actual development of tolerance to dopamine."


    Also, consider switching to Ritalin, which is likely to be less neurotoxic.


    Adderall can be made far safer if some general guidelines are followed. Additionally, this will also help with reducing comedowns and other side effects.

    Dosing and Moderation


    • When you first use Adderall, it will make you want to do things that you consider "work". This effect will go away. Upping the dosage may help slightly, however is extremely unadvisable.

    • An option: Give all of your Adderall to a roommate, and have them moderate your Adderall. (e.g. you can say that they will give you one Addy every 2 days, and that on certain days if you are really busy that you can receive as much as 2 pills, but no more)

    • Time off for heavy users: Aim to take at least one day a week off, and at least one week off every few months.

    • Time off for moderate users: Avoid dosing two days in a row.



    In general, take it as infrequently as possible.

    Adderall Drug Combinations


    Avoid mixing with:


    • Caffeine or tobacco: You will sleep better and have softer comedowns. Additionally, adderall + caffeine/cigarettes/tobacco can cause a synergistic addiction to the caffeine - avoid.
    • Smoking too much marijuana on Adderall can harm your heart.
    • Alcohol: Generally not a good idea. Messes with your head.

    General Health


    Sleep well! Aim for 8 hours.


    Eat well! Aim for 2 solid meals. The less processed food, the better. Aim for dark vegetables and fruits.

    Pushing It Too Far

    When should you take a few days off?


    Any of the following?


    • Using Adderall or Vyvanse to pull all nighters lately?

    • Finding people and minor annoyances extremely frustrating?

    • Movements in the corners of your eyes?

    • Adderall not lasting as long?

    • Feel both exhausted and energetic at once?

    • Always feeling like you should be doing something, or are missing something?


    If so:

    • Take a few days off.

    • Get extra sleep. Aim for 9 hours a night.

    • Eat well and avoid processed foods. Aim for lots of vegetables and fruit.