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Recent Articles

Methylmalonic Acidemia and Megaloblastic Anemia due to Congenital Intrinsic Factor Deficiency

Causes of vitamin B12 deficiency in children include decreased intake, abnormal absorption, and inborn errors of B12 transport and metabolism. Rare causes of abnormal cobalamin absorption include Imerslund-Grasbeck syndrome (IGS) and intrinsic factor deficiency (IFD). IGS and IFD are caused by defects in the genes CUBN, AMN, and GIF. We describe a 2 year old male who presented with severe megaloblastic anemia and methylmalonic acidemia. He was found to have a GIF heterozygous mutation c.79+1G>A associated with congenital gastric intrinsic factor deficiency and a novel variant c.960C>A in trans position.

Anti-Diabetic Activity of Lycopene Niosomes: Experimental Observation

The lycopene is a known bioactive constituent of Lycopersicum esculentum and its application in diabetes is an active area of research. The lycopene has disadvantages such as susceptible to light, heat, and oxidants, which limit its therapeutic applications. In the present investigation, we reported lycopene niosomes formulation which can enhance its anti-diabetic application. The niosome formulation was prepared to preserve lycopene activity.



