Observational Studies

The goal of this study is to determine whether there is a preclinical FTD stage where those at risk for FTD have changes in their brain structure but no symptoms of FTD.

This trial will study the efficacy and tolerability of drugs targeting Alzheimer's disease in patients with a genetic predisposition to the disease.

This study examines how the proteins tau and amyloid affect brain regions and relate to symptoms of typical and atypical Alzheimer's disease (AD).

This survey aims to help researchers better understand how the experience of caregiving affects mental health and wellbeing.

This telephone support intervention aims to help caregivers by providing them with the support and strategies they need to manage challenging behaviors.

This study examines the progression and symptoms of primary progressive aphasia (PPA) and differentiates subtypes of PPA.

The goal of the study is to obtain a uniform set of data from individuals who have various types of dementia (e.g., Alzheimer’s disease, frontotemporal degeneration, lewy body dementia, etc..) and from healthy older individuals in order to understand how dementia (a decline in mental ability) develops in the human brain.

The purpose of the ADNI-3 study is to create a national database of brain aging from volunteers age 55 - 90, to improve clinical trials and provide researchers across the country with data to study how quickly brain cognition and function changes. This study is funded by the National Institutes of Health.


Healthy, normal volunteers needed for a study of brain protein deposits that commonly occur with normal aging. This study involves 4 PET scans, 1 MRI scan, and cognitive testing. The scans are 30-120 minutes in length and the cognitive testing can last up to 2 hours.

• The Memory Unit and the Integrated Brain Health Clinical and Research Program at Massachusetts General Hospital (MGH) are developing an exercise and mind body program to promote physical and emotional health.

• We hope to optimize the program, based on your feedback, to better serve patients with chronic pain and memory problems.

If you are interested in participating, please click the following link to sign-up: https://rally.partners.org/study/activebrains