

Scientists led by John Kuwada, professor of molecular, cellular and developmental biology at the University of Michigan, and Hiromi Hirata of the National Institute of Genetics in Japan originally identified the gene in mutant zebrafish that exhibited severe muscle weakness. Native American myopathy causes muscle weakness from birth and other severe problems that can lead to death before adulthood.

The findings appear in the journal Nature Communications.

The responsible gene encodes for a muscle protein called Stac3, which in turn regulates a physiological process required for muscle contraction. The muscles of zebrafish and people with the genetic mutation don't make normal Stac3 protein and the muscles don't contract effectively.

