DLG7 Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Belongs to the SAPAP family. Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule-binding
Chromosomal Location of Human Ortholog: 14q22.3
Cellular Component:  cytosol; microtubule organizing center; mitochondrion; nucleus; spindle pole centrosome
Molecular Function:  phosphoprotein phosphatase activity; protein binding
Biological Process:  cell proliferation; mitotic chromosome movement towards spindle pole; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription of Notch receptor target; protein dephosphorylation
Reference #:  Q15398 (UniProtKB)
Alt. Names/Synonyms: DAP-5; Discs large homolog 7; discs, large (Drosophila) homolog-associated protein 5; discs, large homolog 7; Disks large-associated protein 5; Disks large-associated protein DLG7; DLG7; DLGAP5; DLGP5; Drosophila discs large-1 tumor suppressor-like; Hepatoma up-regulated protein; HURP; KIAA0008
Gene Symbols: DLGAP5
Molecular weight: 95,115 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.
