jueves, 22 de mayo de 2014

CDC-MERS-Case Definitions

CDC-MERS-Case Definitions

Case Definitions

Patient Under Investigation (PUI)

  1. Fever (≥38°C, 100.4°F) and pneumonia or acute respiratory distress syndrome (based on clinical or radiological evidence) AND EITHER:
    • a history of travel from countries in or near the Arabian Peninsula1 within 14 days before symptom onset, OR
    • close contact2 with a symptomatic traveler who developed fever and acute respiratory illness (not necessarily pneumonia) within 14 days after traveling from countries in or near the Arabian Peninsula1 OR
  2. Close contact2 with a confirmed or probable case of MERS while the case was ill AND
    • fever (>100°F) or symptoms of respiratory illness within 14 days following the close contact. (This is a lower threshold than category A.)
PUIs should be evaluated in consultation with the state and local health departments. For more information, see CDC’s Interim Guidance for Health Professionals.

Confirmed Case

A confirmed case is a person with laboratory confirmation3 of MERS-CoV infection.

Probable Case

A probable case is a PUI with absent or inconclusive4 laboratory results for MERS-CoV infection who is a close contact2 of a laboratory-confirmed MERS-CoV case.


  1. Countries considered in the Arabian Peninsula and neighboring include: Bahrain, Gaza Strip, Iraq, Iran, Israel, Jordan, Kuwait, Lebanon, Oman, Qatar, Saudi Arabia, Syria, the United Arab Emirates (UAE), the West Bank, and Yemen.
  3. Confirmatory laboratory testing requires a positive PCR on at least two specific genomic targets or a single positive target with sequencing on a second.
  4. Examples of laboratory results that may be considered inconclusive include a positive test on a single PCR target, a positive test with an assay that has limited performance data available, or a negative test on an inadequate specimen.

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