MAPPIT opportunities

MAPPIT features

MAPPIT applications

The MAPPIT technology suite offers a set of highly complementary tools for the analysis of interactions among proteins or between proteins and small organic molecules in mammalian cells. In basic research it is being applied in interactome analysis, both for the detailed examination of designated protein-protein interactions, for cDNA library screening experiments and for systematic large scale interactome mapping projects.

Through the combination of its three core techniques, MAPPIT constitutes a valuable platform for drug discovery and pre-clinical analysis of compounds that act by disrupting protein-protein interactions, a novel class of therapeutics. ForwardMAPPIT allows for the identification of target protein interactions. Using ReverseMAPPIT, small molecule libraries can be screened for compounds that interfere with these target interactions. MASPIT permits target profiling and optimization of the identified lead compounds.

A selection of example MAPPIT applications can be found here.