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Title: L-ap4  
Author: World Heritage Encyclopedia
Language: English
Subject: DNQX, DCPG, LY-341,495, WAY-213,613, Nitromemantine
Collection: Amino Acids, Mglu4 Receptor Agonists, Mglu6 Receptor Agonists, Mglu7 Receptor Agonists, Mglu8 Receptor Agonists, Phosphonic Acids
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(2S)-2-amino-4-phosphonobutanoic acid
CAS Registry Number  YesY
PubChem CID:
ChemSpider  N
Chemical data
Formula C4H10NO5P
Molecular mass 183.099 g/mol

L-2-amino-4-phosphonobutyric acid (or L-AP4) is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]


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