"Our technology could help launch a new generation of materials that actively work with tissues to drive healing."Ben Almquist, Imperial College London

Materials are widely used to help heal wounds: collagen sponges help treat burns and pressure sores, and scaffold-like implants are used to repair bones. But the process of tissue repair tends to change over time, so scientists are developing biomaterials that interact with tissues as healing takes place.

Now, Ben Almquist and his team at Imperial College London in the UK have created a new molecule that could change the way traditional materials work with the body. Known as traction force-activated payloads (TrAPs), their method lets materials talk to the body's natural repair systems to drive healing.

The researchers say incorporating TrAPs into existing medical materials could revolutionize the way injuries are treated. "Our technology could help launch a new generation of materials that actively work with tissues to drive healing," said Almquist, who is in Imperial's Department of Bioengineering. Almquist and his team report their findings in a paper in Advanced Materials.

After an injury, cells 'crawl' through the collagen 'scaffolds' found in wounds, like spiders navigating webs. As they move, they pull on the scaffold, activating hidden healing proteins that begin to repair injured tissue.

The researchers designed TrAPs as a way to recreate this natural healing method. They folded DNA segments into three-dimensional shapes known as aptamers that cling tightly to proteins. Then, they attached a customizable 'handle' that cells can grab onto on one end, before attaching the opposite end to a scaffold such as collagen.

During laboratory testing of their technique, they found that cells pulled on the TrAPs as they crawled through the collagen scaffolds. This pulling made the TrAPs unravel like shoelaces to reveal and activate healing proteins, which instruct healing cells to grow and multiply.

The researchers also found that, by changing the cellular 'handle', they can change which type of cell can grab hold and pull, allowing TrAPs to be tailored to release specific therapeutic proteins based on which cells are present at a given point in time. In doing so, the TrAPs produce materials that can smartly interact with the correct type of cell at the correct time during wound repair.

This is the first time that scientists have activated healing proteins using different types of cells in man-made materials, mimicking healing methods found in nature. "Using cell movement to activate healing is found in creatures ranging from sea sponges to humans," said Almquist. "Our approach mimics them and actively works with the different varieties of cells that arrive in our damaged tissue over time to promote healing."

This approach is adaptable to different cell types and so could be used in a variety of injuries, such as fractured bones, scar tissue after heart attacks and damaged nerves. New techniques are also desperately needed for patients whose wounds won't heal despite current interventions. Such wounds include diabetic foot ulcers, which are the leading cause of non-traumatic lower leg amputations.

TrAPs are relatively straightforward to create and are fully man-made, meaning they are easily recreated in different labs and can be scaled up to industrial quantities. Their adaptability also means they could help scientists to create new methods for laboratory studies of diseases, stem cells and tissue development.

Aptamers are currently used as drugs, meaning they are already proven safe and optimized for clinical use. Because TrAPs take advantage of aptamers that are currently optimized for use in humans, they may be able to take a shorter path to the clinic than methods that start from ground zero.

"The TrAP technology provides a flexible method to create materials that actively communicate with the wound and provide key instructions when and where they are needed," said Almquist. "This sort of intelligent, dynamic healing is useful during every phase of the healing process, has the potential to increase the body's chance to recover, and has far-reaching uses on many different types of wounds. This technology has the potential to serve as a conductor of wound repair, orchestrating different cells over time to work together to heal damaged tissues."

This story is adapted from material from Imperial College London, with editorial changes made by Materials Today. The views expressed in this article do not necessarily represent those of Elsevier. Link to original source.