Nav: Home

Cell biology: Positioning the cleavage furrow

January 11, 2018

Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich have identified a signaling pathway that restricts cleavage furrow formation to the mid-plane of the cell.

Cell division is a fundamental biological process which ensures that, following the replication of the mother cell's genome, the two sets of chromosomes are equally distributed between two daughter cells. Chromosomes are segregated by the spindle apparatus, which is made up of fibrous protein structures called microtubules. The spindle apparatus is anchored to the opposite poles of the cell and determines the position of the future cleavage site in the middle of the cell, where a contractile protein ring is assembled. LMU researchers led by cell biologist Dr. Esther Zanin, who heads an Emmy Noether Research Group at the LMU Biocenter, have identified a molecular signaling pathway that restricts formation of the contractile ring to the mid-plane of the mother cell. Their findings appear in the Journal of Cell Biology.

Correct segregation of the chromosomes requires precise positioning of the cleavage furrow to the mid-plane of the cell. To achieve this, the spindle apparatus sends out two signals. One of these actively stimulates formation of the contractile ring at the mid-plane of the cell while a second signal inhibits its assembly at the cell poles. The inhibitory signal is known to originate from the so-called astral microtubules, which project to the cell poles from the spindle apparatus. "However, the molecular constituents of this signal have remained unknown until now," says Zanin. "With the help of a newly developed and highly sensitive method, we have now shown in the nematode Caenorhabditis elegans - a popular model organism in cell biology - that the enzyme Aurora A is a central component of the inhibitory signal."

Aurora A, which is also present in human cells, is known to play a crucial role in the control of spindle assembly, and is activated on the astral microtubules. "We think that the active enzyme then diffuses from the astral microtubules to the cell membrane at the cell poles, where it suppresses formation of a contractile ring." Zanin explains. In multicellular organisms, the precise control of cell division is not only essential during embryonic development, but also in the adult organism. Defects in cell division can causes numerous diseases including cancers." A detailed understanding of this fundamental process is therefore a prerequisite for the development of more effective ways to treat and prevent such disorders," says Zanin.

Ludwig-Maximilians-Universität München

Related Chromosomes Articles:

Andalusian experts indicate new elements responsible for instability in chromosomes
The researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNA.
Reconstruction of ancient chromosomes offers insight into mammalian evolution
Researchers have gone back in time, at least virtually, computationally recreating the chromosomes of the first eutherian mammal, the long-extinct, shrewlike ancestor of all placental mammals.
Newly discovered DNA sequences can protect chromosomes in rotifers
For keeping X chromosomes active, chromosome 19 marks the spot
Researchers assemble five new synthetic chromosomes
Jumbled chromosomes may dampen the immune response to tumors
How well a tumor responds to immunotherapy may depend in part on whether its chromosomes are intact or in a state of disarray, a new study reports.
Aging and cancer: An enzyme protects chromosomes from oxidative damage
EPFL scientists have identified a protein that caps chromosomes during cell division and protect them from oxidative damage and shortening, which are associated with aging and cancer.
Protective barrier inside chromosomes helps to keep cells healthy
Fresh insights into the structures that contain our genetic material could explain how the body's cells stay healthy.
How human eggs end up with the wrong number of chromosomes
One day before ovulation, human oocytes begin to divide into what will become mature eggs.
Genes versus chromosomes: A battle for expression in fly testes
Unique sex chromosomes occur in many species. An unequal pair of sex chromosomes, each carrying a different complement of genes, requires specific efforts to regulate and balance the expression of sex-chromosomal genes.

Related Chromosomes Reading:

Best Science Podcasts 2019

Now Playing: TED Radio Hour

Jumpstarting Creativity
Now Playing: Science for the People

#524 The Human Network