
Alcohol Withdrawal









Rating Nutritional Supplements Herbs


Milk thistle

D,L-phenylalanine (DLPA)
Evening primrose oil
Multiple vitamin-mineral
Vitamin A
Vitamin B-complex
Vitamin B3
Vitamin B6
Vitamin C
Vitamin D
Vitamin E


Reliable and relatively consistent scientific data showing a substantial health benefit.


What are the symptoms of alcohol withdrawal?


Dietary changes that may be helpful for alcohol withdrawal

Some of the nutritional deficiencies associated with alcoholism can be caused by a poor diet—a factor that needs correction on an individual basis. Improving the overall diet should be done in conjunction with a doctor. Sometimes liver or pancreatic disease associated with alcoholism also contributes to nutritional deficiencies. These problems require medical assessment and intervention.

In one trial, a hospital diet was compared with a special diet including fruit and wheat germ and excluding caffeinated coffee, junk food, dairy products, and peanut butter.1 After six months, fewer than 38% of those on the hospital diet remained sober, compared with over 81% of those eating the special diet. A review of the research shows that diets loaded with junk food increase alcohol intake in animals.2 In a human trial, restricting sugar, increasing complex carbohydrates, and eliminating caffeine also led to a reduction in alcohol craving.3 While the support for dietary intervention remains somewhat unclear, some doctors suggest that alcoholics reduce sugar and junk food intake and avoid caffeine.


Lifestyle changes that may be helpful for alcohol withdrawal



Nutritional supplements that may be helpful for alcohol withdrawal

Many alcoholics are deficient in B vitamins, including vitamin B3. John Cleary, M.D., observed that some alcoholics spontaneously stopped drinking in association with taking niacin supplements (niacin is a form of vitamin B3). Cleary concluded that alcoholism might be a manifestation of niacin deficiency in some people and recommended that alcoholics consider supplementation with 500 mg of niacin per day.4 Without specifying the amount of niacin used, Cleary’s preliminary research findings suggested that niacin supplementation helped wean some alcoholics away from alcohol.5 Activated vitamin B3 used intravenously has also helped alcoholics quit drinking.6 Niacinamide—a safer form of the same vitamin—might have similar actions and has been reported to improve alcohol metabolism in animals.7

Deficiencies of other B-complex vitamins are common with chronic alcohol use.8 The situation is exacerbated by the fact that alcoholics have an increased need for B vitamins.9 It is possible that successful treatment of B-complex vitamin deficiencies may actually reduce alcohol cravings, because animals crave alcohol when fed a B-complex-deficient diet.10 Many doctors recommend 100 mg of B-complex vitamins per day.

Alcoholics may be deficient in a substance called prostaglandin E1 (PGE1) and in gamma-linolenic acid (GLA), a precursor to PGE1.11 In a double-blind study of alcoholics who were in a detoxification program, supplementation with 4 grams per day of evening primrose oil (containing 360 mg of GLA) led to greater improvement than did placebo in some, but not all, parameters of liver function.12

The daily combination of 3 grams of vitamin C, 3 grams of niacin, 600 mg of vitamin B6, and 600 IU of vitamin E has been used by researchers from the University of Mississippi Medical Center in an attempt to reduce anxiety and depression in alcoholics.13 Although the effect of vitamin supplementation was no better than placebo in treating alcohol-associated depression, the vitamins did result in a significant drop in anxiety within three weeks of use. Because of possible side effects, anyone taking such high amounts of niacin and vitamin B6 must do so only under the care of a doctor.

Although the incidence of B-complex deficiencies is known to be high in alcoholics, the incidence of other vitamin deficiencies remains less clear.14 Nonetheless, deficiencies of vitamin A, vitamin D, vitamin E, and vitamin C are seen in many alcoholics. While some reports have suggested it may be safer for alcoholics to supplement with beta-carotene instead of vitamin A,1516 These problems result in part because the combinations of alcohol and vitamin A or alcohol and beta-carotene appear to increase potential damage to the liver. Thus, vitamin A-depleted alcoholics require a doctor’s intervention, including supplementation with vitamin A and beta-carotene accompanied by assessment of liver function. Supplementing with vitamin C, on the other hand, appears to help the body rid itself of alcohol.17 Some doctors recommend 1 to 3 grams per day of vitamin C. potential problems accompany the use of either vitamin A or beta-carotene in correcting the deficiency induced by alcoholism.

Kenneth Blum and researchers at the University of Texas have examined neurotransmitter deficiencies in alcoholics. Neurotransmitters are the chemicals the body makes to allow nerve cells to pass messages (of pain, touch, thought, etc.) from cell to cell. Amino acids are the precursors of these neurotransmitters. In double-blind research, a group of alcoholics were treated with 1.5 grams of D,L-phenylalanine (DLPA), 900 mg of L-tyrosine, 300 mg of L-glutamine, and 400 mg of L-tryptophan (now available only by prescription) per day, plus a multivitamin-mineral supplement.18 This nutritional supplement regimen led to a significant reduction in withdrawal symptoms and decreased stress in alcoholics compared to the effects of placebo.

The amino acid, L-glutamine, has also been used as an isolated supplement. Animal research has shown that glutamine supplementation reduces alcohol intake, a finding that has been confirmed in double-blind human research.19 In that trial, 1 gram of glutamine per day given in divided portions with meals decreased both the desire to drink and anxiety levels.

Alcoholics are sometimes deficient in magnesium, and some researchers believe that symptoms of withdrawal may result in part from this deficiency.20 Nonetheless, a double-blind trial reported that magnesium injections did not reduce symptoms of alcohol withdrawal.21

Because of the multiple nutrient deficiencies associated with alcoholism, most alcoholics who quit drinking should supplement with a high-potency multivitamin-mineral for at least several months after the detoxification period. Whether or not the supplement should include iron should be discussed with a doctor.


Are there any side effects or interactions with alcohol withdrawal?


Herbs that may be helpful for alcohol withdrawal

Milk thistle extract is commonly recommended to counteract the harmful effects of alcohol on the liver.22 Milk thistle extracts have been shown in one double-blind study to reduce death due to alcohol-induced cirrhosis of the liver,23 though another double-blind study did not confirm this finding.24 Milk thistle extract may protect the cells of the liver by both blocking the entrance of harmful toxins and helping remove these toxins from the liver cells.25 26 Milk thistle has also been reported to regenerate injured liver cells.27

Kudzu is most famous as a quick-growing weed in the southern United States. Alcoholic hamsters (one of the few animals to become so besides humans) were found to have decreased interest in drinking when fed kudzu extract.28 Traditional Chinese medicine practitioners generally recommend 3 to 5 grams of root three times per day; some herbal practitioners also suggest that 3 to 4 ml of tincture taken three times per day may also be helpful to reduce alcohol cravings. Nonetheless, a double-blind trial using 1.2 grams of powdered kudzu root twice per day failed to show any benefit in helping alcoholics remain abstinent from alcohol.29

Are there any side effects or interactions with alcohol withdrawal?
