Scientists discover schizophrenia gene roles in brain development



It's the first time these molecules, which are associated with the disrupted-in-schizophrenia 1 (DISC1) linked to , have been identified. The scientists developed new tools involving to determine chemical reactions the proteins use to influence cell functions and nerve growth in people.


The findings appear in Biological Psychiatry.


The DISC1 gene was linked to schizophrenia nearly 20 years ago. It controls how called neurons develop, as well as how the brain matures. DISC1 also directs a network of signals across cells that can contribute to the disease. Scientists say errors in these contribute to schizophrenia.



Identifying the proteins that interact with DISC1 in could lead to understanding how the risk factors for psychiatric diseases are connected to specific molecular functions, Coba explained. The discovery enables researchers to determine specific processes that differ in patients suffering from specific mental illnesses.

"This gives researchers specific trails to follow within from both healthy patients and those diagnosed with disorders," Coba said.


The illness is often accompanied by conditions such as heart disease and diabetes, which contribute to the high premature mortality rate among people with schizophrenia. About 5 percent of people with die by suicide, a rate far greater than the general population, with the highest risk in the early stages of illness, according to the NIMH.

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More information: Brent Wilkinson et al, Endogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders, Biological Psychiatry (2018). DOI: 10.1016/j.biopsych.2018.05.009
Journal information: Biological Psychiatry

Citation: Scientists discover schizophrenia gene roles in brain development (2018, June 8) retrieved 26 May 2019 from https://medicalxpress.com/news/2018-06-scientists-schizophrenia-gene-roles-brain.html

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Jun 08, 2018
Ad hoc rationalization of a fribulation.
Don't feed the narrator, just be with the sensation.
Satori in, wu-wei out.
Couple, decouple, its not random,
If even Nature needed the homeostatic to round.

Anxiety should be a driving force. Disassociation a means of not resisting pain.
Meaning comes for the patient. Temptation doesn't for the the practiced.
I have heard Yoga helps those with schizophrenia. Cardio vascular activity as well.
Probably even super brain Yoga, would help people readjust their genetic expression of the genetic identity with enough time.
I don't buy behavior, but if I am here, I buy healing. If I'm not, I might have done it! (just don't swat)
