Acute phase protein

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In the context of tissue damage (injury, operation, infection), a non-specific immune reaction ( acute phase reaction , SIRS ) occurs. Endothelial cells , fibroblasts and inflammatory cells such. B. Macrophages in the damaged tissue release messenger substances ("mediators"), e.g. B. interleukin-1 , interleukin-6 , TNF-α , TGF-β , gamma interferon , EGF , LIF and the like. a. that reach the liver via the bloodstream . There, in the presence of cortisol , they stimulate the liver to increase the synthesis of around 30 different acute phase proteins . Their concentration increases one to two thousand times within 6–48 hours after the damaging event.


Acute phase proteins

Anti-acute phase proteins

Anti-acute phase proteins, also known as "negative acute phase proteins", show falling serum concentrations in acute inflammation. They include:


Biochemistry & Pathobiochemistry, Löffler Petrides, 7th edition, Springer-Verlag, 2003