




Gene Review

PDS5  -  Pds5p

Saccharomyces cerevisiae S288c

Synonyms: Precocious dissociation of sisters protein 5, Sister chromatid cohesion protein PDS5, YM9582.01C, YM9916.15C, YMR076C

High impact information on PDS5

  • Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion [1].
  • We report that pds5 mutants establish cohesion, but during mitosis exhibit precocious sister dissociation [1].
  • The PDS5 gene (precocious dissociation of sisters) was identified in a genetic screen designed to identify genes important for chromosome structure [2].
  • PDS5 is an essential gene and homologues are found from yeast to humans [2].
  • Pds5p is required to maintain cohesion at centromere proximal and distal sequences [2].

Biological context of PDS5


Anatomical context of PDS5

  • In HeLa cells, Pds5 proteins physically interact with cohesin and associate with chromatin in a cohesin-dependent manner [5].

Regulatory relationships of PDS5

  • TOP2 suppresses mini-chromosome loss in pds5 mutants indicating that it rescues a chromosome segregation defect [6].

Other interactions of PDS5


  1. Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion. Stead, K., Aguilar, C., Hartman, T., Drexel, M., Meluh, P., Guacci, V. J. Cell Biol. (2003) [Pubmed]
  2. Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae. Hartman, T., Stead, K., Koshland, D., Guacci, V. J. Cell Biol. (2000) [Pubmed]
  3. Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion. Zhang, Z., Ren, Q., Yang, H., Conrad, M.N., Guacci, V., Kateneva, A., Dresser, M.E. Mol. Microbiol. (2005) [Pubmed]
  4. Pds5 cooperates with cohesin in maintaining sister chromatid cohesion. Panizza, S., Tanaka, T., Hochwagen, A., Eisenhaber, F., Nasmyth, K. Curr. Biol. (2000) [Pubmed]
  5. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. Losada, A., Yokochi, T., Hirano, T. J. Cell. Sci. (2005) [Pubmed]
  6. Topoisomerase II suppresses the temperature sensitivity of Saccharomyces cerevisiae pds5 mutants, but not the defect in sister chromatid cohesion. Aguilar, C., Davidson, C., Dix, M., Stead, K., Zheng, K., Hartman, T., Guacci, V. Cell Cycle (2005) [Pubmed]
  7. Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis. Wang, F., Yoder, J., Antoshechkin, I., Han, M. Mol. Cell. Biol. (2003) [Pubmed]
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