

MedKoo CAT#: 414561

CAS#: 186752-78-3

Description: Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5

Chemical Structure

CAS# 186752-78-3

Theoretical Analysis

MedKoo Cat#: 414561
Name: Olcorolimus
CAS#: 186752-78-3
Chemical Formula: C51H81NO12
Exact Mass: 899.5759
Molecular Weight: 900.2
Elemental Analysis: C, 68.05; H, 9.07; N, 1.56; O, 21.33

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Synonym: Olcorolimus; SAR943; SAR943-NXA; SAR943N

IUPAC/Chemical Name: UNKNOWN


InChi Code: InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1

SMILES Code: CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@H]([C@@H]2CC[C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C[C@@H]3CC[C@H]([C@@](O3)(C(C(N4CCCC[C@H]4C(O2)=O)=O)=O)O)C)\C)C)C)=O)OC)O)\C)C)C

Appearance: Solid powder




Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined


HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 900.2 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Eynott PR, Salmon M, Huang TJ, Oates T, Nicklin PL, Chung KF. Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats. Immunology. 2003 Jul;109(3):461-7. doi: 10.1046/j.1365-2567.2003.01672.x. PMID: 12807493; PMCID: PMC1782985.

2: Huang TJ, Eynott P, Salmon M, Nicklin PL, Chung KF. Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats. Eur J Pharmacol. 2002 Feb 22;437(3):187-94. doi: 10.1016/s0014-2999(02)01295-5. PMID: 11890908.

3: Tigani B, Hannon JP, Schaeublin E, Mazzoni L, Fozard JR. Effects of immunomodulators on airways hyperresponsiveness to adenosine induced in actively sensitised Brown Norway rats by exposure to allergen. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):17-25. doi: 10.1007/s00210-003-0767-7. Epub 2003 Jun 24. PMID: 12827216.

4: Strom T, Shokati T, Klawitter J, Klawitter J, Hoffman K, Schiebel HM, Christians U. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. J Mass Spectrom. 2011 Jul;46(7):615-24. doi: 10.1002/jms.1930. PMID: 21671437.