@article {172734, title = {The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study.}, journal = {British journal of cancer}, volume = {120}, year = {2019}, pages = {883-895}, abstract = {


METHODS: Consecutive women undergoing mastectomy {\textpm} IBR for breast cancer July-December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy {\textpm} IBR were compared and risk factors associated with delays explored.

RESULTS: A total of 2540 patients were recruited from 76 centres; 1008 (39.7\%) underwent IBR (implant-only [n = 675, 26.6\%]; pedicled flaps [n = 105,4.1\%] and free-flaps [n = 228, 8.9\%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6\%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.


}, author = {O{\textquoteright}Connell, Rachel L and Rattay, Tim and Dave, Rajiv V and Trickey, Adam and Skillman, Joanna and Barnes, Nicola L P and Gardiner, Matthew and Harnett, Adrian and Potter, Shelley and Holcombe, Chris} }