@article {10.7554/eLife.63355, article_type = {journal}, title = {Spherical arena reveals optokinetic response tuning to stimulus location, size, and frequency across entire visual field of larval zebrafish}, author = {Dehmelt, Florian A and Meier, Rebecca and Hinz, Julian and Yoshimatsu, Takeshi and Simacek, Clara A and Huang, Ruoyu and Wang, Kun and Baden, Tom and Arrenberg, Aristides B}, editor = {Tessmar-Raible, Kristin and Moore, Tirin and Straw, Andrew D}, volume = 10, year = 2021, month = {jun}, pub_date = {2021-06-08}, pages = {e63355}, citation = {eLife 2021;10:e63355}, doi = {10.7554/eLife.63355}, url = {https://doi.org/10.7554/eLife.63355}, abstract = {Many animals have large visual fields, and sensory circuits may sample those regions of visual space most relevant to behaviours such as gaze stabilisation and hunting. Despite this, relatively small displays are often used in vision neuroscience. To sample stimulus locations across most of the visual field, we built a spherical stimulus arena with 14,848 independently controllable LEDs. We measured the optokinetic response gain of immobilised zebrafish larvae to stimuli of different steradian size and visual field locations. We find that the two eyes are less yoked than previously thought and that spatial frequency tuning is similar across visual field positions. However, zebrafish react most strongly to lateral, nearly equatorial stimuli, consistent with previously reported spatial densities of red, green, and blue photoreceptors. Upside-down experiments suggest further extra-retinal processing. Our results demonstrate that motion vision circuits in zebrafish are anisotropic, and preferentially monitor areas with putative behavioural relevance.}, keywords = {optokinetic response, visual field, retinal photoreceptors, asymmetry, yoking, stimulus tuning}, journal = {eLife}, issn = {2050-084X}, publisher = {eLife Sciences Publications, Ltd}, }