The medical management of primary sclerosing cholangitis

Anthony Michaels, Cynthia Levy

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.

Original languageEnglish (US)
Article number61
JournalMedGenMed Medscape General Medicine
Issue number3
StatePublished - Apr 24 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'The medical management of primary sclerosing cholangitis'. Together they form a unique fingerprint.

Cite this