




Gene Review

ANXA3  -  annexin A3

Homo sapiens

Synonyms: 35-alpha calcimedin, ANX3, Annexin A3, Annexin III, Annexin-3, ...

Disease relevance of ANXA3


High impact information on ANXA3

  • Amino acid sequence of several peptides derived from the purified protein revealed that it is identical to lipocortin III, a recently described member of the annexin family that is scarce in other cells and tissues [6].
  • The structure of the gene indicates that different forms of PAP are produced by alternative splicing (PAPs I and II) or by competition between polyadenylation and splicing (PAP III) [7].
  • Coupled with the fact that this is a particularly abundant phospholipid in granules specific to neutrophils, cells where annexin III is highly expressed, our finding could be pointing to a physiological role of annexin III [8].
  • The BIAcoreTM system used with different phospholipids showed that annexin III displays specificity for phosphatidylethanolamine, but not for phosphatidylinositols [8].

Biological context of ANXA3


Anatomical context of ANXA3


Associations of ANXA3 with chemical compounds

  • In this study, three additional anticoagulant proteins (PAP-II, PAP-III, and PAP-IV) were simultaneously isolated from human placental homogenates prepared in the presence of 5 mM ethylenediaminetetraacetic acid [13].
  • Local recurrent androgen ablation therapy-resistant tumours exhibit heterogenous low levels of ANXA3 staining [2].
  • The most differentially abundant proteins between cancer and benign samples were isopeptidase T, serum amyloid P (SAP), annexin A3 (ANXA3) and mitochondrial enoyl coenzyme-A hydratase [2].
  • Our studies clearly show that cyclic inositol phosphohydrolase and annexin III are two different proteins [11].
  • The tryptophan in the calcium loop of the third domain is exposed to the solvent, as in the structure of annexin V crystallized in high calcium concentrations, although the annexin III crystals were prepared at low calcium concentrations [14].

Physical interactions of ANXA3


Regulatory relationships of ANXA3

  • Taken together, our results suggest that ANXA3 is a novel angiogenic factor that induces VEGF production through the HIF-1 pathway [9].

Other interactions of ANXA3


Analytical, diagnostic and therapeutic context of ANXA3


  1. Gene expression analysis to identify mRNA markers of cardiac myxoma. Skamrov, A.V., Nechaenko, M.A., Goryunova, L.E., Feoktistova, E.S., Khaspekov, G.L., Kovalevsky, D.A., Vinnitsky, L.I., Sheremeteva, G.F., Beabealashvilli, R.S.h. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  2. Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: Cancer association of annexin A3. Wozny, W., Schroer, K., Schwall, G.P., Poznanovi??, S., Stegmann, W., Dietz, K., Rogatsch, H., Schaefer, G., Huebl, H., Klocker, H., Schrattenholz, A., Cahill, M.A. Proteomics (2007) [Pubmed]
  3. High resolution X-ray structure of potent anti-HIV pokeweed antiviral protein-III. Kurinov, I.V., Uckun, F.M. Biochem. Pharmacol. (2003) [Pubmed]
  4. Structure and polymorphisms of the human annexin III (ANX3) gene. Tait, J.F., Smith, C., Xu, L., Cookson, B.T. Genomics (1993) [Pubmed]
  5. Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1. Rajamohan, F., Venkatachalam, T.K., Irvin, J.D., Uckun, F.M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  6. Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. Ernst, J.D., Hoye, E., Blackwood, R.A., Jaye, D. J. Clin. Invest. (1990) [Pubmed]
  7. Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Zhao, W., Manley, J.L. Mol. Cell. Biol. (1996) [Pubmed]
  8. Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III? Perron, B., Lewit-Bentley, A., Geny, B., Russo-Marie, F. J. Biol. Chem. (1997) [Pubmed]
  9. Annexin A3 is a potential angiogenic mediator. Park, J.E., Lee, d.o. .H., Lee, J.A., Park, S.G., Kim, N.S., Park, B.C., Cho, S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  10. Chromosomal localization of the human annexin III (ANX3) gene. Tait, J.F., Frankenberry, D.A., Miao, C.H., Killary, A.M., Adler, D.A., Disteche, C.M. Genomics (1991) [Pubmed]
  11. Dissociation of cyclic inositol phosphohydrolase activity from annexin III. Sekar, M.C., Sambandam, V., Grizzle, W.E., McDonald, J.M. J. Biol. Chem. (1996) [Pubmed]
  12. Role of annexins in endocytosis of antigens in immature human dendritic cells. Larsson, M., Majeed, M., Ernst, J.D., Magnusson, K.E., Stendahl, O., Forsum, U. Immunology (1997) [Pubmed]
  13. Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. Tait, J.F., Sakata, M., McMullen, B.A., Miao, C.H., Funakoshi, T., Hendrickson, L.E., Fujikawa, K. Biochemistry (1988) [Pubmed]
  14. The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. Favier-Perron, B., Lewit-Bentley, A., Russo-Marie, F. Biochemistry (1996) [Pubmed]
  15. Gene expression profiling in cluster headache: a pilot microarray study. Sj??strand, C., Duvefelt, K., Steinberg, A., Remahl, I.N., Waldenlind, E., Hillert, J. Headache (2006) [Pubmed]
  16. Strategy of treatment of submucosal gastric tumors. Sato, T., Peiper, M., Fritscher-Ravens, A., Gocht, A., Soehendra, N., Knoefel, W.T. Eur. J. Med. Res. (2005) [Pubmed]
  17. The crystal structure of annexin A8 is similar to that of annexin A3. Réty, S., Sopková-de Oliveira Santos, J., Dreyfuss, L., Blondeau, K., Hofbauerová, K., Raguénès-Nicol, C., Kerboeuf, D., Renouard, M., Russo-Marie, F., Lewit-Bentley, A. J. Mol. Biol. (2005) [Pubmed]
  18. Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. Ross, T.S., Tait, J.F., Majerus, P.W. Science (1990) [Pubmed]
  19. Annexin III translocates to the periphagosomal region when neutrophils ingest opsonized yeast. Ernst, J.D. J. Immunol. (1991) [Pubmed]
  20. Lipocortins are major substrates for protein kinase C in extracts of human neutrophils. Stoehr, S.J., Smolen, J.E., Suchard, S.J. J. Immunol. (1990) [Pubmed]
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