###User: À quelle heure part le dernier train pisa centrale — venezia mestre ?  ###Assistant: The last train from [pisa centrale](https://www.thetrainline.com/fr/gares/pisa-centrale) to [venezia mestre](https://www.thetrainline.com/fr/gares/venezia-mestre) leaves at 22:30. trains that depart in the early morning hours or very late evening may be sleeper services, time and services may also vary during weekends and holidays.