Effect of retinoic acid (RA) on the Epstein-Barr virus (EBV)-inducing effect of sodium butyrate.
Sodium butyrate is a powerful inducer of the Epstein-Barr virus (EBV) cycle in the P3HR-1 cell line. Retinoic acid (RA) was found to reduce the butyrate induction of early antigen (EA) and viral capsid antigen (VCA) by 26-41%. This is similar to the previously reported effect of RA on IUDR and TPA induction, with certain quantitative differences between the systems.