The influence of sex on patients with rheumatoid arthritis in a large observational cohort.
To compare the sex differences of various components of rheumatoid arthritis (RA). Data of 4823 patients from a large observational cohort study were analyzed. Remarkable differences were noted between the sexes, and overall, women had significantly higher disease activity. When variables were adjusted using sex, age, and duration, Health Assessment Questionnaire, rather than Disease Activity Score, contributed most to sex difference. Further analysis showed evidence that progression of disability was approximately 3 times more rapid in female patients compared to male patients. Women overall have higher RA disease activity and are prone to greater and faster progression of disability over time.