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Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | BRCA1 is secreted and exhibits properties of a granin . | BRCA1 : O
is : O
secreted : O
and : O
exhibits : O
properties : O
of : O
a : O
granin : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Germline mutations in BRCA1 are responsible for most cases of inherited breast and ovarian cancer . | Germline : O
mutations : O
in : O
BRCA1 : O
are : O
responsible : O
for : O
most : O
cases : O
of : O
inherited : B
breast : I
and : I
ovarian : I
cancer : I
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | However , the function of the BRCA1 protein has remained elusive . | However : O
, : O
the : O
function : O
of : O
the : O
BRCA1 : O
protein : O
has : O
remained : O
elusive : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | We now show that BRCA1 encodes a 190 - kD protein with sequence homology and biochemical analogy to the granin protein family . | We : O
now : O
show : O
that : O
BRCA1 : O
encodes : O
a : O
190 : O
- : O
kD : O
protein : O
with : O
sequence : O
homology : O
and : O
biochemical : O
analogy : O
to : O
the : O
granin : O
protein : O
family : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Interestingly , BRCA2 also includes a motif similar to the granin consensus at the C terminus of the protein . | Interestingly : O
, : O
BRCA2 : O
also : O
includes : O
a : O
motif : O
similar : O
to : O
the : O
granin : O
consensus : O
at : O
the : O
C : O
terminus : O
of : O
the : O
protein : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Both BRCA1 and the granins localize to secretory vesicles , are secreted by a regulated pathway , are post - translationally glycosylated and are responsive to hormones . | Both : O
BRCA1 : O
and : O
the : O
granins : O
localize : O
to : O
secretory : O
vesicles : O
, : O
are : O
secreted : O
by : O
a : O
regulated : O
pathway : O
, : O
are : O
post : O
- : O
translationally : O
glycosylated : O
and : O
are : O
responsive : O
to : O
hormones : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | As a regulated secretory protein , BRCA1 appears to function by a mechanism not previously described for tumour suppressor gene products . . | As : O
a : O
regulated : O
secretory : O
protein : O
, : O
BRCA1 : O
appears : O
to : O
function : O
by : O
a : O
mechanism : O
not : O
previously : O
described : O
for : O
tumour : B
suppressor : O
gene : O
products : O
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat ( VNTR ) locus . | Ovarian : B
cancer : I
risk : O
in : O
BRCA1 : O
carriers : O
is : O
modified : O
by : O
the : O
HRAS1 : O
variable : O
number : O
of : O
tandem : O
repeat : O
( : O
VNTR : O
) : O
locus : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Women who carry a mutation in the BRCA1 gene ( on chromosome 17q21 ) , have an 80 % risk of breast cancer and a 40 % risk of ovarian cancer by the age of 70 ( ref . 1 ) . | Women : O
who : O
carry : O
a : O
mutation : O
in : O
the : O
BRCA1 : O
gene : O
( : O
on : O
chromosome : O
17q21 : O
) : O
, : O
have : O
an : O
80 : O
% : O
risk : O
of : O
breast : B
cancer : I
and : O
a : O
40 : O
% : O
risk : O
of : O
ovarian : B
cancer : I
by : O
the : O
age : O
of : O
70 : O
( : O
ref : O
. : O
1 : O
) : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The variable penetrance of BRCA1 suggests that other genetic and non - genetic factors play a role in tumourigenesis in these individuals . | The : O
variable : O
penetrance : O
of : O
BRCA1 : O
suggests : O
that : O
other : O
genetic : O
and : O
non : O
- : O
genetic : O
factors : O
play : O
a : O
role : O
in : O
tumourigenesis : O
in : O
these : O
individuals : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The HRAS1 variable number of tandem repeats ( VNTR ) polymorphism , located 1 kilobase ( kb ) downstream of the HRAS1 proto - oncogene ( chromosome 11p15 . 5 ) is one possible genetic modifier of cancer penetrance . | The : O
HRAS1 : O
variable : O
number : O
of : O
tandem : O
repeats : O
( : O
VNTR : O
) : O
polymorphism : O
, : O
located : O
1 : O
kilobase : O
( : O
kb : O
) : O
downstream : O
of : O
the : O
HRAS1 : O
proto : O
- : O
oncogene : O
( : O
chromosome : O
11p15 : O
. : O
5 : O
) : O
is : O
one : O
possible : O
genetic : O
modifier : O
of : O
cancer : B
penetrance : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Individuals who have rare alleles of the VNTR have an increased risk of certain types of cancers , including breast cancer ( 2 - 4 ) . | Individuals : O
who : O
have : O
rare : O
alleles : O
of : O
the : O
VNTR : O
have : O
an : O
increased : O
risk : O
of : O
certain : O
types : O
of : O
cancers : B
, : O
including : O
breast : B
cancer : I
( : O
2 : O
- : O
4 : O
) : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | To investigate whether the presence of rare HRAS1 alleles increases susceptibility to hereditary breast and ovarian cancer , we have typed a panel of 307 female BRCA1 carriers at this locus using a PCR - based technique . | To : O
investigate : O
whether : O
the : O
presence : O
of : O
rare : O
HRAS1 : O
alleles : O
increases : O
susceptibility : O
to : O
hereditary : B
breast : I
and : I
ovarian : I
cancer : I
, : O
we : O
have : O
typed : O
a : O
panel : O
of : O
307 : O
female : O
BRCA1 : O
carriers : O
at : O
this : O
locus : O
using : O
a : O
PCR : O
- : O
based : O
technique : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The risk for ovarian cancer was 2 . | The : O
risk : O
for : O
ovarian : B
cancer : I
was : O
2 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | 11 times greater for BRCA1 carriers harbouring one or two rare HRAS1 alleles , compared to carriers with only common alleles ( P = 0 . 015 ) . | 11 : O
times : O
greater : O
for : O
BRCA1 : O
carriers : O
harbouring : O
one : O
or : O
two : O
rare : O
HRAS1 : O
alleles : O
, : O
compared : O
to : O
carriers : O
with : O
only : O
common : O
alleles : O
( : O
P : O
= : O
0 : O
. : O
015 : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The magnitude of the relative risk associated with a rare HRAS1 allele was not altered by adjusting for the other known risk factors for hereditary ovarian cancer ( 5 ) . | The : O
magnitude : O
of : O
the : O
relative : O
risk : O
associated : O
with : O
a : O
rare : O
HRAS1 : O
allele : O
was : O
not : O
altered : O
by : O
adjusting : O
for : O
the : O
other : O
known : O
risk : O
factors : O
for : O
hereditary : B
ovarian : I
cancer : I
( : O
5 : O
) : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Susceptibility to breast cancer did not appear to be affected by the presence of rare HRAS1 alleles . | Susceptibility : O
to : O
breast : B
cancer : I
did : O
not : O
appear : O
to : O
be : O
affected : O
by : O
the : O
presence : O
of : O
rare : O
HRAS1 : O
alleles : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | This study is the first to show the effect of a modifying gene on the penetrance of an inherited cancer syndrome | This : O
study : O
is : O
the : O
first : O
to : O
show : O
the : O
effect : O
of : O
a : O
modifying : O
gene : O
on : O
the : O
penetrance : O
of : O
an : O
inherited : B
cancer : I
syndrome : I | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | A novel homeodomain - encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable ( CTG ) n repeat . | A : O
novel : O
homeodomain : O
- : O
encoding : O
gene : O
is : O
associated : O
with : O
a : O
large : O
CpG : O
island : O
interrupted : O
by : O
the : O
myotonic : B
dystrophy : I
unstable : O
( : O
CTG : O
) : O
n : O
repeat : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Myotonic dystrophy ( DM ) is associated with a ( CTG ) n trinucleotide repeat expansion in the 3 - untranslated region of a protein kinase - encoding gene , DMPK , which maps to chromosome 19q13 . | Myotonic : B
dystrophy : I
( : O
DM : B
) : O
is : O
associated : O
with : O
a : O
( : O
CTG : O
) : O
n : O
trinucleotide : O
repeat : O
expansion : O
in : O
the : O
3 : O
- : O
untranslated : O
region : O
of : O
a : O
protein : O
kinase : O
- : O
encoding : O
gene : O
, : O
DMPK : O
, : O
which : O
maps : O
to : O
chromosome : O
19q13 : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | 3 . | 3 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Characterisation of the expression of this gene in patient tissues has thus far generated conflicting data on alterations in the steady state levels of DMPK mRNA , and on the final DMPK protein levels in the presence of the expansion . | Characterisation : O
of : O
the : O
expression : O
of : O
this : O
gene : O
in : O
patient : O
tissues : O
has : O
thus : O
far : O
generated : O
conflicting : O
data : O
on : O
alterations : O
in : O
the : O
steady : O
state : O
levels : O
of : O
DMPK : O
mRNA : O
, : O
and : O
on : O
the : O
final : O
DMPK : O
protein : O
levels : O
in : O
the : O
presence : O
of : O
the : O
expansion : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The DM region of chromosome 19 is gene rich , and it is possible that the repeat expansion may lead to dysfunction of a number of transcription units in the vicinity , perhaps as a consequence of chromatin disruption . | The : O
DM : B
region : O
of : O
chromosome : O
19 : O
is : O
gene : O
rich : O
, : O
and : O
it : O
is : O
possible : O
that : O
the : O
repeat : O
expansion : O
may : O
lead : O
to : O
dysfunction : O
of : O
a : O
number : O
of : O
transcription : O
units : O
in : O
the : O
vicinity : O
, : O
perhaps : O
as : O
a : O
consequence : O
of : O
chromatin : O
disruption : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | We have searched for genes associated with a CpG island at the 3 end of DMPK . | We : O
have : O
searched : O
for : O
genes : O
associated : O
with : O
a : O
CpG : O
island : O
at : O
the : O
3 : O
end : O
of : O
DMPK : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Sequencing of this region shows that the island extends over 3 . | Sequencing : O
of : O
this : O
region : O
shows : O
that : O
the : O
island : O
extends : O
over : O
3 : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | 5 kb and is interrupted by the ( CTG ) n repeat . | 5 : O
kb : O
and : O
is : O
interrupted : O
by : O
the : O
( : O
CTG : O
) : O
n : O
repeat : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Comparison of genomic sequences downstream ( centromeric ) of the repeat in human and mouse identified regions of significant homology . | Comparison : O
of : O
genomic : O
sequences : O
downstream : O
( : O
centromeric : O
) : O
of : O
the : O
repeat : O
in : O
human : O
and : O
mouse : O
identified : O
regions : O
of : O
significant : O
homology : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | These correspond to exons of a gene predicted to encode a homeodomain protein . | These : O
correspond : O
to : O
exons : O
of : O
a : O
gene : O
predicted : O
to : O
encode : O
a : O
homeodomain : O
protein : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | RT - PCR analysis shows that this gene , which we have called DM locus - associated homeodomain protein ( DMAHP ) , is expressed in a number of human tissues , including skeletal muscle , heart and brain . | RT : O
- : O
PCR : O
analysis : O
shows : O
that : O
this : O
gene : O
, : O
which : O
we : O
have : O
called : O
DM : B
locus : O
- : O
associated : O
homeodomain : O
protein : O
( : O
DMAHP : O
) : O
, : O
is : O
expressed : O
in : O
a : O
number : O
of : O
human : O
tissues : O
, : O
including : O
skeletal : O
muscle : O
, : O
heart : O
and : O
brain : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Germline mutations in the RB1 gene in patients with hereditary retinoblastoma . | Germline : O
mutations : O
in : O
the : O
RB1 : O
gene : O
in : O
patients : O
with : O
hereditary : B
retinoblastoma : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | We have analyzed the 27 exons and the promoter region of the RB1 gene in familial or sporadic bilateral retinoblastoma by using single - strand conformation polymorphism analysis . | We : O
have : O
analyzed : O
the : O
27 : O
exons : O
and : O
the : O
promoter : O
region : O
of : O
the : O
RB1 : O
gene : O
in : O
familial : B
or : I
sporadic : I
bilateral : I
retinoblastoma : I
by : O
using : O
single : O
- : O
strand : O
conformation : O
polymorphism : O
analysis : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | For improvement over previous studies , a new set of primers has been designed , which allow for amplification of the coding and splicing sequences only . | For : O
improvement : O
over : O
previous : O
studies : O
, : O
a : O
new : O
set : O
of : O
primers : O
has : O
been : O
designed : O
, : O
which : O
allow : O
for : O
amplification : O
of : O
the : O
coding : O
and : O
splicing : O
sequences : O
only : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The positioning of the polymerase chain reaction ( PCR ) primers was such that the resulting PCR products were of different sizes , which enabled us to analyze two different exons simultaneously and still distinguish between the banding profiles for both ( biplex analysis ) . | The : O
positioning : O
of : O
the : O
polymerase : O
chain : O
reaction : O
( : O
PCR : O
) : O
primers : O
was : O
such : O
that : O
the : O
resulting : O
PCR : O
products : O
were : O
of : O
different : O
sizes : O
, : O
which : O
enabled : O
us : O
to : O
analyze : O
two : O
different : O
exons : O
simultaneously : O
and : O
still : O
distinguish : O
between : O
the : O
banding : O
profiles : O
for : O
both : O
( : O
biplex : O
analysis : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | By using this approach , we were able to identify mutation in 22 new patients , but the overall efficiency of the procedure when we used a single - pass regimen was only 48 % . | By : O
using : O
this : O
approach : O
, : O
we : O
were : O
able : O
to : O
identify : O
mutation : O
in : O
22 : O
new : O
patients : O
, : O
but : O
the : O
overall : O
efficiency : O
of : O
the : O
procedure : O
when : O
we : O
used : O
a : O
single : O
- : O
pass : O
regimen : O
was : O
only : O
48 : O
% : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The mutations were small insertions and deletions and point mutations in roughly equal proportions . . | The : O
mutations : O
were : O
small : O
insertions : O
and : O
deletions : O
and : O
point : O
mutations : O
in : O
roughly : O
equal : O
proportions : O
. : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Type II human complement C2 deficiency . | Type : B
II : I
human : I
complement : I
C2 : I
deficiency : I
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Allele - specific amino acid substitutions ( Ser189 - - > Phe ; Gly444 - - > Arg ) cause impaired C2 secretion . | Allele : O
- : O
specific : O
amino : O
acid : O
substitutions : O
( : O
Ser189 : O
- : O
- : O
> : O
Phe : O
; : O
Gly444 : O
- : O
- : O
> : O
Arg : O
) : O
cause : O
impaired : O
C2 : O
secretion : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Type II complement protein C2 deficiency is characterized by a selective block in C2 secretion . | Type : B
II : I
complement : I
protein : I
C2 : I
deficiency : I
is : O
characterized : O
by : O
a : O
selective : O
block : O
in : O
C2 : O
secretion : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The Type II C2 null allele ( C2Q0 ) is linked to two major histocompatibility haplotypes ( MHC ) that differ from the MHC of the more common Type I C2 deficiency . | The : O
Type : O
II : O
C2 : O
null : O
allele : O
( : O
C2Q0 : O
) : O
is : O
linked : O
to : O
two : O
major : O
histocompatibility : O
haplotypes : O
( : O
MHC : O
) : O
that : O
differ : O
from : O
the : O
MHC : O
of : O
the : O
more : O
common : O
Type : B
I : I
C2 : I
deficiency : I
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | To determine the molecular basis of Type II deficiency the two Type II C2Q0 genes were isolated and transfected separately into L - cells . | To : O
determine : O
the : O
molecular : O
basis : O
of : O
Type : B
II : I
deficiency : I
the : O
two : O
Type : O
II : O
C2Q0 : O
genes : O
were : O
isolated : O
and : O
transfected : O
separately : O
into : O
L : O
- : O
cells : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Subsequent molecular biology , biosynthetic , and immunofluorescence studies demonstrated that C2 secretion is impaired in Type II C2 deficiency because of different missense mutations at highly conserved residues in each of the C2Q0 alleles . | Subsequent : O
molecular : O
biology : O
, : O
biosynthetic : O
, : O
and : O
immunofluorescence : O
studies : O
demonstrated : O
that : O
C2 : O
secretion : O
is : O
impaired : O
in : O
Type : B
II : I
C2 : I
deficiency : I
because : O
of : O
different : O
missense : O
mutations : O
at : O
highly : O
conserved : O
residues : O
in : O
each : O
of : O
the : O
C2Q0 : O
alleles : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | One is in exon 5 ( nucleotide C566 - - > T ; Ser189 - - > Phe ) of the C2Q0 gene linked to the MHC haplotype A11 , B35 , DRw1 , BFS , C4A0B1 . | One : O
is : O
in : O
exon : O
5 : O
( : O
nucleotide : O
C566 : O
- : O
- : O
> : O
T : O
; : O
Ser189 : O
- : O
- : O
> : O
Phe : O
) : O
of : O
the : O
C2Q0 : O
gene : O
linked : O
to : O
the : O
MHC : O
haplotype : O
A11 : O
, : O
B35 : O
, : O
DRw1 : O
, : O
BFS : O
, : O
C4A0B1 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The other is in exon 11 ( G1930 - - > A ; Gly444 - - > Arg ) of the C2Q0 gene linked to the MHC haplotype A2 , B5 , DRw4 , BFS , C4A3B1 . | The : O
other : O
is : O
in : O
exon : O
11 : O
( : O
G1930 : O
- : O
- : O
> : O
A : O
; : O
Gly444 : O
- : O
- : O
> : O
Arg : O
) : O
of : O
the : O
C2Q0 : O
gene : O
linked : O
to : O
the : O
MHC : O
haplotype : O
A2 : O
, : O
B5 : O
, : O
DRw4 : O
, : O
BFS : O
, : O
C4A3B1 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Each mutant C2 gene product is retained early in the secretory pathway . | Each : O
mutant : O
C2 : O
gene : O
product : O
is : O
retained : O
early : O
in : O
the : O
secretory : O
pathway : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | These mutants provide models for elucidating the C2 secretory pathway . . | These : O
mutants : O
provide : O
models : O
for : O
elucidating : O
the : O
C2 : O
secretory : O
pathway : O
. : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Defective dimerization of von Willebrand factor subunits due to a Cys - > Arg mutation in type IID von Willebrand disease . | Defective : O
dimerization : O
of : O
von : B
Willebrand : I
factor : O
subunits : O
due : O
to : O
a : O
Cys : O
- : O
> : O
Arg : O
mutation : O
in : O
type : B
IID : I
von : I
Willebrand : I
disease : I
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The same heterozygous T - > C transition at nt 8567 of the von Willebrand factor ( vWF ) transcript was found in two unrelated patients with type IID von Willebrand disease , with no other apparent abnormality . | The : O
same : O
heterozygous : O
T : O
- : O
> : O
C : O
transition : O
at : O
nt : O
8567 : O
of : O
the : O
von : B
Willebrand : I
factor : O
( : O
vWF : O
) : O
transcript : O
was : O
found : O
in : O
two : O
unrelated : O
patients : O
with : O
type : B
IID : I
von : I
Willebrand : I
disease : I
, : O
with : O
no : O
other : O
apparent : O
abnormality : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | In one family , both alleles were normal in the parents and one sister ; thus , the mutation originated de novo in the proposita . | In : O
one : O
family : O
, : O
both : O
alleles : O
were : O
normal : O
in : O
the : O
parents : O
and : O
one : O
sister : O
; : O
thus : O
, : O
the : O
mutation : O
originated : O
de : O
novo : O
in : O
the : O
proposita : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The second patient also had asymptomatic parents who , however , were not available for study . | The : O
second : O
patient : O
also : O
had : O
asymptomatic : O
parents : O
who : O
, : O
however : O
, : O
were : O
not : O
available : O
for : O
study : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The structural consequences of the identified mutation , resulting in the CyS2010 - > Arg substitution , were evaluated by expression of the vWF carboxyl - terminal domain containing residues 1366 - 2050 . | The : O
structural : O
consequences : O
of : O
the : O
identified : O
mutation : O
, : O
resulting : O
in : O
the : O
CyS2010 : O
- : O
> : O
Arg : O
substitution : O
, : O
were : O
evaluated : O
by : O
expression : O
of : O
the : O
vWF : O
carboxyl : O
- : O
terminal : O
domain : O
containing : O
residues : O
1366 : O
- : O
2050 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Insect cells infected with recombinant baculovirus expressing normal vWF sequence secreted a disulfide linked dimeric molecule with an apparent molecular mass of 150 kDa before reduction , yielding a single band of 80 kDa after disulfide bond reduction . | Insect : O
cells : O
infected : O
with : O
recombinant : O
baculovirus : O
expressing : O
normal : O
vWF : O
sequence : O
secreted : O
a : O
disulfide : O
linked : O
dimeric : O
molecule : O
with : O
an : O
apparent : O
molecular : O
mass : O
of : O
150 : O
kDa : O
before : O
reduction : O
, : O
yielding : O
a : O
single : O
band : O
of : O
80 : O
kDa : O
after : O
disulfide : O
bond : O
reduction : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | In contrast , cells expressing the mutant fragment secreted a monomeric molecule of apparent molecular mass of 80 kDa , which remained unchanged after reduction . | In : O
contrast : O
, : O
cells : O
expressing : O
the : O
mutant : O
fragment : O
secreted : O
a : O
monomeric : O
molecule : O
of : O
apparent : O
molecular : O
mass : O
of : O
80 : O
kDa : O
, : O
which : O
remained : O
unchanged : O
after : O
reduction : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | We conclude that CyS2010 is essential for normal dimerization of vWF subunits through disulfide bonding of carboxyl - terminal domains and that a heterozygous mutation in the corresponding codon is responsible for defective multimer formation in type IID von Willebrand disease . . | We : O
conclude : O
that : O
CyS2010 : O
is : O
essential : O
for : O
normal : O
dimerization : O
of : O
vWF : O
subunits : O
through : O
disulfide : O
bonding : O
of : O
carboxyl : O
- : O
terminal : O
domains : O
and : O
that : O
a : O
heterozygous : O
mutation : O
in : O
the : O
corresponding : O
codon : O
is : O
responsible : O
for : O
defective : O
multimer : O
formation : O
in : O
type : B
IID : I
von : I
Willebrand : I
disease : I
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Wiskott - Aldrich syndrome protein , a novel effector for the GTPase CDC42Hs , is implicated in actin polymerization . | Wiskott : B
- : I
Aldrich : I
syndrome : I
protein : O
, : O
a : O
novel : O
effector : O
for : O
the : O
GTPase : O
CDC42Hs : O
, : O
is : O
implicated : O
in : O
actin : O
polymerization : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The Rho family of GTPases control diverse biological processes , including cell morphology and mitogenesis . | The : O
Rho : O
family : O
of : O
GTPases : O
control : O
diverse : O
biological : O
processes : O
, : O
including : O
cell : O
morphology : O
and : O
mitogenesis : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | We have identified WASP , the protein that is defective in Wiskott - Aldrich syndrome ( WAS ) , as a novel effector for CDC42Hs , but not for the other Rho family members , Rac and Rho . | We : O
have : O
identified : O
WASP : O
, : O
the : O
protein : O
that : O
is : O
defective : O
in : O
Wiskott : B
- : I
Aldrich : I
syndrome : I
( : O
WAS : B
) : O
, : O
as : O
a : O
novel : O
effector : O
for : O
CDC42Hs : O
, : O
but : O
not : O
for : O
the : O
other : O
Rho : O
family : O
members : O
, : O
Rac : O
and : O
Rho : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | This interaction is dependent on the presence of the G protein - binding domain . | This : O
interaction : O
is : O
dependent : O
on : O
the : O
presence : O
of : O
the : O
G : O
protein : O
- : O
binding : O
domain : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Cellular expression of epitope - tagged WASP produces clusters of WASP that are highly enriched in polymerized actin . | Cellular : O
expression : O
of : O
epitope : O
- : O
tagged : O
WASP : O
produces : O
clusters : O
of : O
WASP : O
that : O
are : O
highly : O
enriched : O
in : O
polymerized : O
actin : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | This clustering is not observed with a C - terminally deleted WASP and is inhibited by coexpression with dominant negative CDC42Hs - N17 , but not with dominant negative forms of Rac or Rho . | This : O
clustering : O
is : O
not : O
observed : O
with : O
a : O
C : O
- : O
terminally : O
deleted : O
WASP : O
and : O
is : O
inhibited : O
by : O
coexpression : O
with : O
dominant : O
negative : O
CDC42Hs : O
- : O
N17 : O
, : O
but : O
not : O
with : O
dominant : O
negative : O
forms : O
of : O
Rac : O
or : O
Rho : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Thus , WASP provides a novel link between CDC42Hs and the actin cytoskeleton , which suggests a molecular mechanism for many of the cellular abnormalities in WAS . | Thus : O
, : O
WASP : O
provides : O
a : O
novel : O
link : O
between : O
CDC42Hs : O
and : O
the : O
actin : O
cytoskeleton : O
, : O
which : O
suggests : O
a : O
molecular : O
mechanism : O
for : O
many : O
of : O
the : O
cellular : O
abnormalities : O
in : O
WAS : B
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The WASP sequence contains two novel domains that are homologous to other proteins involved in action organization . . | The : O
WASP : O
sequence : O
contains : O
two : O
novel : O
domains : O
that : O
are : O
homologous : O
to : O
other : O
proteins : O
involved : O
in : O
action : O
organization : O
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | X - linked adrenoleukodystrophy is a frequent cause of idiopathic Addison ' s disease in young adult male patients . | X : B
- : I
linked : I
adrenoleukodystrophy : I
is : O
a : O
frequent : O
cause : O
of : O
idiopathic : O
Addison : B
' : I
s : I
disease : I
in : O
young : O
adult : O
male : O
patients : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | X - Linked adrenoleukodystrophy ( ALD ) is a genetic disease associated with demyelination of the central nervous system , adrenal insufficiency , and accumulation of very long chain fatty acids in tissue and body fluids . | X : B
- : I
Linked : I
adrenoleukodystrophy : I
( : O
ALD : B
) : O
is : O
a : O
genetic : B
disease : I
associated : O
with : O
demyelination : B
of : I
the : I
central : I
nervous : I
system : I
, : O
adrenal : B
insufficiency : I
, : O
and : O
accumulation : O
of : O
very : O
long : O
chain : O
fatty : O
acids : O
in : O
tissue : O
and : O
body : O
fluids : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | ALD is due to mutation of a gene located in Xq28 that encodes a peroxisomal transporter protein of unknown function . | ALD : B
is : O
due : O
to : O
mutation : O
of : O
a : O
gene : O
located : O
in : O
Xq28 : O
that : O
encodes : O
a : O
peroxisomal : O
transporter : O
protein : O
of : O
unknown : O
function : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The most common phenotype of ALD is the cerebral form ( 45 % ) that develops in boys between 5 - 12 yr . | The : O
most : O
common : O
phenotype : O
of : O
ALD : B
is : O
the : O
cerebral : O
form : O
( : O
45 : O
% : O
) : O
that : O
develops : O
in : O
boys : O
between : O
5 : O
- : O
12 : O
yr : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Adrenomyeloneuropathy ( AMN ) involves the spinal cord and peripheral nerves in young adults ( 35 % ) . | Adrenomyeloneuropathy : B
( : O
AMN : B
) : O
involves : O
the : O
spinal : O
cord : O
and : O
peripheral : O
nerves : O
in : O
young : O
adults : O
( : O
35 : O
% : O
) : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Adrenal insufficiency ( Addisons disease ) is frequently associated with AMN or cerebral ALD and may remain the only clinical expression of ALD ( 8 % of cases ) . | Adrenal : B
insufficiency : I
( : O
Addisons : B
disease : I
) : O
is : O
frequently : O
associated : O
with : O
AMN : B
or : O
cerebral : B
ALD : I
and : O
may : O
remain : O
the : O
only : O
clinical : O
expression : O
of : O
ALD : B
( : O
8 : O
% : O
of : O
cases : O
) : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The prevalence of ALD among adults with Addisons disease remains unknown . | The : O
prevalence : O
of : O
ALD : B
among : O
adults : O
with : O
Addisons : B
disease : I
remains : O
unknown : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | To evaluate this prevalence , we performed biochemical analysis of very long chain fatty acids in 14 male patients ( age ranging from 12 - 45 yr at diagnosis ) previously diagnosed as having primary idiopathic adrenocortical insufficiency . | To : O
evaluate : O
this : O
prevalence : O
, : O
we : O
performed : O
biochemical : O
analysis : O
of : O
very : O
long : O
chain : O
fatty : O
acids : O
in : O
14 : O
male : O
patients : O
( : O
age : O
ranging : O
from : O
12 : O
- : O
45 : O
yr : O
at : O
diagnosis : O
) : O
previously : O
diagnosed : O
as : O
having : O
primary : O
idiopathic : O
adrenocortical : B
insufficiency : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | In 5 of 14 patients ( 35 % ) , elevated plasma concentrations of very long chain fatty acids were detected . | In : O
5 : O
of : O
14 : O
patients : O
( : O
35 : O
% : O
) : O
, : O
elevated : O
plasma : O
concentrations : O
of : O
very : O
long : O
chain : O
fatty : O
acids : O
were : O
detected : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | None of these patients had adrenocortical antibodies . | None : O
of : O
these : O
patients : O
had : O
adrenocortical : O
antibodies : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | By electrophysiological tests and magnetic resonance imaging it was determined that two patients had cerebral ALD , one had adrenomyeloneuropathy with cerebral involvement , and two had preclinical AMN . | By : O
electrophysiological : O
tests : O
and : O
magnetic : O
resonance : O
imaging : O
it : O
was : O
determined : O
that : O
two : O
patients : O
had : O
cerebral : B
ALD : I
, : O
one : O
had : O
adrenomyeloneuropathy : B
with : O
cerebral : O
involvement : O
, : O
and : O
two : O
had : O
preclinical : O
AMN : B
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Our data support the hypothesis that ALD is a frequent cause of idiopathic Addisons disease in children and adults . . | Our : O
data : O
support : O
the : O
hypothesis : O
that : O
ALD : B
is : O
a : O
frequent : O
cause : O
of : O
idiopathic : O
Addisons : B
disease : I
in : O
children : O
and : O
adults : O
. : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter - q11 . | Tumor : B
suppression : O
and : O
apoptosis : O
of : O
human : O
prostate : B
carcinoma : I
mediated : O
by : O
a : O
genetic : O
locus : O
within : O
human : O
chromosome : O
10pter : O
- : O
q11 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Prostate cancer is the second leading cause of male cancer deaths in the United States . | Prostate : B
cancer : I
is : O
the : O
second : O
leading : O
cause : O
of : O
male : O
cancer : B
deaths : O
in : O
the : O
United : O
States : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Yet , despite a large international effort , little is known about the molecular mechanisms that underlie this devastating disease . | Yet : O
, : O
despite : O
a : O
large : O
international : O
effort : O
, : O
little : O
is : O
known : O
about : O
the : O
molecular : O
mechanisms : O
that : O
underlie : O
this : O
devastating : O
disease : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Prostate secretory epithelial cells and androgen - dependent prostate carcinomas undergo apoptosis in response to androgen deprivation and , furthermore , most prostate carcinomas become androgen independent and refractory to further therapeutic manipulations during disease progression . | Prostate : O
secretory : O
epithelial : O
cells : O
and : O
androgen : O
- : O
dependent : O
prostate : B
carcinomas : I
undergo : O
apoptosis : O
in : O
response : O
to : O
androgen : O
deprivation : O
and : O
, : O
furthermore : O
, : O
most : O
prostate : B
carcinomas : I
become : O
androgen : O
independent : O
and : O
refractory : O
to : O
further : O
therapeutic : O
manipulations : O
during : O
disease : O
progression : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Definition of the genetic events that trigger apoptosis in the prostate could provide important insights into critical pathways in normal development as well as elucidate the perturbations of those key pathways in neoplastic transformation . | Definition : O
of : O
the : O
genetic : O
events : O
that : O
trigger : O
apoptosis : O
in : O
the : O
prostate : O
could : O
provide : O
important : O
insights : O
into : O
critical : O
pathways : O
in : O
normal : O
development : O
as : O
well : O
as : O
elucidate : O
the : O
perturbations : O
of : O
those : O
key : O
pathways : O
in : O
neoplastic : O
transformation : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | We report the functional definition of a novel genetic locus within human chromosome 10pter - q11 that mediates both in vivo tumor suppression and in vitro apoptosis of prostatic adenocarcinoma cells . | We : O
report : O
the : O
functional : O
definition : O
of : O
a : O
novel : O
genetic : O
locus : O
within : O
human : O
chromosome : O
10pter : O
- : O
q11 : O
that : O
mediates : O
both : O
in : O
vivo : O
tumor : O
suppression : O
and : O
in : O
vitro : O
apoptosis : O
of : O
prostatic : B
adenocarcinoma : I
cells : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | A defined fragment of human chromosome 10 was transferred via microcell fusion into a prostate adenocarcinoma cell line . | A : O
defined : O
fragment : O
of : O
human : O
chromosome : O
10 : O
was : O
transferred : O
via : O
microcell : O
fusion : O
into : O
a : O
prostate : B
adenocarcinoma : I
cell : O
line : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Microcell hybrids containing only the region 10pter - q11 were suppressed for tumorigenicity following injection of microcell hybrids into nude mice . | Microcell : O
hybrids : O
containing : O
only : O
the : O
region : O
10pter : O
- : O
q11 : O
were : O
suppressed : O
for : O
tumorigenicity : O
following : O
injection : O
of : O
microcell : O
hybrids : O
into : O
nude : O
mice : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Furthermore , the complemented hybrids undergo programmed cell death in vitro via a mechanism that does not require nuclear localization of p53 . | Furthermore : O
, : O
the : O
complemented : O
hybrids : O
undergo : O
programmed : O
cell : O
death : O
in : O
vitro : O
via : O
a : O
mechanism : O
that : O
does : O
not : O
require : O
nuclear : O
localization : O
of : O
p53 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | These data functionally define a novel genetic locus , designated PAC1 , for prostate adenocarcinoma 1 , involved in tumor suppression of human prostate carcinoma and furthermore strongly suggest that the cell death pathway can be functionally restored in prostatic adenocarcinoma . . | These : O
data : O
functionally : O
define : O
a : O
novel : O
genetic : O
locus : O
, : O
designated : O
PAC1 : O
, : O
for : O
prostate : O
adenocarcinoma : O
1 : O
, : O
involved : O
in : O
tumor : O
suppression : O
of : O
human : O
prostate : B
carcinoma : I
and : O
furthermore : O
strongly : O
suggest : O
that : O
the : O
cell : O
death : O
pathway : O
can : O
be : O
functionally : O
restored : O
in : O
prostatic : B
adenocarcinoma : I
. : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Low incidence of BRCA2 mutations in breast carcinoma and other cancers . | Low : O
incidence : O
of : O
BRCA2 : O
mutations : O
in : O
breast : B
carcinoma : I
and : O
other : O
cancers : B
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Inherited mutant alleles of familial tumour suppressor genes predispose individuals to particular types of cancer . | Inherited : O
mutant : O
alleles : O
of : O
familial : O
tumour : B
suppressor : O
genes : O
predispose : O
individuals : O
to : O
particular : O
types : O
of : O
cancer : B
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | In addition to an involvement in inherited susceptibility to cancer , these tumour suppressor genes are targets for somatic mutations in sporadic cancers of the same type found in the familial forms . | In : O
addition : O
to : O
an : O
involvement : O
in : O
inherited : O
susceptibility : O
to : O
cancer : B
, : O
these : O
tumour : B
suppressor : O
genes : O
are : O
targets : O
for : O
somatic : O
mutations : O
in : O
sporadic : B
cancers : I
of : O
the : O
same : O
type : O
found : O
in : O
the : O
familial : O
forms : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | An exception is BRCA1 , which contributes to a significant fraction of familial breast and ovarian cancer , but undergoes mutation at very low rates in sporadic breast and ovarian cancers . | An : O
exception : O
is : O
BRCA1 : O
, : O
which : O
contributes : O
to : O
a : O
significant : O
fraction : O
of : O
familial : B
breast : I
and : I
ovarian : I
cancer : I
, : O
but : O
undergoes : O
mutation : O
at : O
very : O
low : O
rates : O
in : O
sporadic : B
breast : I
and : I
ovarian : I
cancers : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | This finding suggests that other genes may be the principal targets for somatic mutation in breast carcinoma . | This : O
finding : O
suggests : O
that : O
other : O
genes : O
may : O
be : O
the : O
principal : O
targets : O
for : O
somatic : O
mutation : O
in : O
breast : B
carcinoma : I
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | A second , recently identified familial breast cancer gene , BRCA2 ( refs 5 - 8 ) , accounts for a proportion of breast cancer roughly equal to BRCA1 . | A : O
second : O
, : O
recently : O
identified : O
familial : B
breast : I
cancer : I
gene : O
, : O
BRCA2 : O
( : O
refs : O
5 : O
- : O
8 : O
) : O
, : O
accounts : O
for : O
a : O
proportion : O
of : O
breast : B
cancer : I
roughly : O
equal : O
to : O
BRCA1 : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Like BRCA1 , BRCA2 behaves as a dominantly inherited tumour suppressor gene . | Like : O
BRCA1 : O
, : O
BRCA2 : O
behaves : O
as : O
a : O
dominantly : O
inherited : O
tumour : B
suppressor : O
gene : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Individuals who inherit one mutant allele are at increased risk for breast cancer , and the tumours they develop lose the wild - type allele by heterozygous deletion . | Individuals : O
who : O
inherit : O
one : O
mutant : O
allele : O
are : O
at : O
increased : O
risk : O
for : O
breast : B
cancer : I
, : O
and : O
the : O
tumours : B
they : O
develop : O
lose : O
the : O
wild : O
- : O
type : O
allele : O
by : O
heterozygous : O
deletion : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The BRCA2 coding sequence is huge , composed of 26 exons that span 10 , 443 bp . | The : O
BRCA2 : O
coding : O
sequence : O
is : O
huge : O
, : O
composed : O
of : O
26 : O
exons : O
that : O
span : O
10 : O
, : O
443 : O
bp : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Here we investigate the rate of BRCA2 mutation in sporadic breast cancers and in a set of cell lines that represent twelve other tumour types . | Here : O
we : O
investigate : O
the : O
rate : O
of : O
BRCA2 : O
mutation : O
in : O
sporadic : B
breast : I
cancers : I
and : O
in : O
a : O
set : O
of : O
cell : O
lines : O
that : O
represent : O
twelve : O
other : O
tumour : B
types : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Surprisingly , mutations in BRCA2 are infrequent in cancers including breast carcinoma . | Surprisingly : O
, : O
mutations : O
in : O
BRCA2 : O
are : O
infrequent : O
in : O
cancers : B
including : O
breast : B
carcinoma : I
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | However , a probable germline mutation in a pancreatic tumour cell line suggests a role for BRCA2 in susceptibility to pancreatic cancer . . | However : O
, : O
a : O
probable : O
germline : O
mutation : O
in : O
a : O
pancreatic : B
tumour : I
cell : O
line : O
suggests : O
a : O
role : O
for : O
BRCA2 : O
in : O
susceptibility : O
to : O
pancreatic : B
cancer : I
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Founding BRCA1 mutations in hereditary breast and ovarian cancer in southern Sweden . | Founding : O
BRCA1 : O
mutations : O
in : O
hereditary : B
breast : I
and : I
ovarian : I
cancer : I
in : O
southern : O
Sweden : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Nine different germ - line mutations in the BRCA1 breast and ovarian cancer susceptibility gene were identified in 15 of 47 kindreds from southern Sweden , by use of SSCP and heteroduplex analysis of all exons and flanking intron region and by a protein - truncation test for exon 11 , followed by direct sequencing . | Nine : O
different : O
germ : O
- : O
line : O
mutations : O
in : O
the : O
BRCA1 : O
breast : B
and : I
ovarian : I
cancer : I
susceptibility : O
gene : O
were : O
identified : O
in : O
15 : O
of : O
47 : O
kindreds : O
from : O
southern : O
Sweden : O
, : O
by : O
use : O
of : O
SSCP : O
and : O
heteroduplex : O
analysis : O
of : O
all : O
exons : O
and : O
flanking : O
intron : O
region : O
and : O
by : O
a : O
protein : O
- : O
truncation : O
test : O
for : O
exon : O
11 : O
, : O
followed : O
by : O
direct : O
sequencing : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | All but one of the mutations are predicted to give rise to premature translation termination and include seven frameshift insertions or deletions , a nonsense mutation , and a splice acceptor site mutation . | All : O
but : O
one : O
of : O
the : O
mutations : O
are : O
predicted : O
to : O
give : O
rise : O
to : O
premature : O
translation : O
termination : O
and : O
include : O
seven : O
frameshift : O
insertions : O
or : O
deletions : O
, : O
a : O
nonsense : O
mutation : O
, : O
and : O
a : O
splice : O
acceptor : O
site : O
mutation : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The remaining mutation is a missense mutation ( Cys61Gly ) in the zinc - binding motif . | The : O
remaining : O
mutation : O
is : O
a : O
missense : O
mutation : O
( : O
Cys61Gly : O
) : O
in : O
the : O
zinc : O
- : O
binding : O
motif : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Four novel Swedish founding mutations were identified the nucleotide 2595 deletion A was found in five families , the C 1806 T nonsense mutation in three families , the 3166 insertion TGAGA in three families , and the nucleotide 1201 deletion 11 in two families . | Four : O
novel : O
Swedish : O
founding : O
mutations : O
were : O
identified : O
the : O
nucleotide : O
2595 : O
deletion : O
A : O
was : O
found : O
in : O
five : O
families : O
, : O
the : O
C : O
1806 : O
T : O
nonsense : O
mutation : O
in : O
three : O
families : O
, : O
the : O
3166 : O
insertion : O
TGAGA : O
in : O
three : O
families : O
, : O
and : O
the : O
nucleotide : O
1201 : O
deletion : O
11 : O
in : O
two : O
families : O
. : O | NCBI-disease |
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