# Copyright (c) 2016. Mount Sinai School of Medicine
#
# Licensed under the Apache License, Version 2.0 (the "License");
# you may not use this file except in compliance with the License.
# You may obtain a copy of the License at
#
#     http://www.apache.org/licenses/LICENSE-2.0
#
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.

from __future__ import (
    print_function,
    division,
    absolute_import,
)
from collections import defaultdict

import numpy as np
from fancyimpute.knn import KNN
from fancyimpute.iterative_svd import IterativeSVD
from fancyimpute.simple_fill import SimpleFill
from fancyimpute.soft_impute import SoftImpute
from fancyimpute.mice import MICE
from fancyimpute.biscaler import BiScaler


def check_dense_pMHC_array(X, peptide_list, allele_list):
    if len(peptide_list) != len(set(peptide_list)):
        raise ValueError("Duplicate peptides detected in peptide list")
    if len(allele_list) != len(set(allele_list)):
        raise ValueError("Duplicate alleles detected in allele list")
    n_rows, n_cols = X.shape
    if n_rows != len(peptide_list):
        raise ValueError(
            "Expected dense array with shape %s to have %d rows" % (
                X.shape, len(peptide_list)))
    if n_cols != len(allele_list):
        raise ValueError(
            "Expected dense array with shape %s to have %d columns" % (
                X.shape, len(allele_list)))


def prune_dense_matrix_and_labels(
        X,
        peptide_list,
        allele_list,
        min_observations_per_peptide=1,
        min_observations_per_allele=1):
    """
    Filter the dense matrix of pMHC binding affinities according to
    the given minimum number of row/column observations.

    Parameters
    ----------
    X : numpy.ndarray
        Incomplete dense matrix of pMHC affinity with n_peptides rows and
        n_alleles columns.

    peptide_list : list of str
        Expected to have n_peptides entries

    allele_list : list of str
        Expected to have n_alleles entries

    min_observations_per_peptide : int
        Drop peptide rows with fewer than this number of observed values.

    min_observations_per_allele : int
        Drop allele columns with fewer than this number of observed values.
    """
    observed_mask = np.isfinite(X)
    n_observed_per_peptide = observed_mask.sum(axis=1)
    too_few_peptide_observations = (
        n_observed_per_peptide < min_observations_per_peptide)
    if too_few_peptide_observations.any():
        drop_peptide_indices = np.where(too_few_peptide_observations)[0]
        keep_peptide_indices = np.where(~too_few_peptide_observations)[0]
        print("Dropping %d peptides with <%d observations" % (
            len(drop_peptide_indices),
            min_observations_per_peptide))
        X = X[keep_peptide_indices]
        observed_mask = observed_mask[keep_peptide_indices]
        peptide_list = [peptide_list[i] for i in keep_peptide_indices]

    n_observed_per_allele = observed_mask.sum(axis=0)
    too_few_allele_observations = (
        n_observed_per_allele < min_observations_per_peptide)
    if too_few_peptide_observations.any():
        drop_allele_indices = np.where(too_few_allele_observations)[0]
        keep_allele_indices = np.where(~too_few_allele_observations)[0]
        print("Dropping %d alleles with <%d observations: %s" % (
            len(drop_allele_indices),
            min_observations_per_allele,
            [allele_list[i] for i in drop_allele_indices]))
        X = X[:, keep_allele_indices]
        observed_mask = observed_mask[:, keep_allele_indices]
        allele_list = [allele_list[i] for i in keep_allele_indices]
    check_dense_pMHC_array(X, peptide_list, allele_list)
    return X, peptide_list, allele_list


def dense_pMHC_matrix_to_nested_dict(X, peptide_list, allele_list):
    """
    Converts a dense matrix of (n_peptides, n_alleles) floats to a nested
    dictionary from allele -> peptide -> affinity.
    """
    allele_to_peptide_to_ic50_dict = defaultdict(dict)
    for row_index, peptide in enumerate(peptide_list):
        for column_index, allele_name in enumerate(allele_list):
            affinity = X[row_index, column_index]
            if np.isfinite(affinity):
                allele_to_peptide_to_ic50_dict[allele_name][peptide] = affinity
    return allele_to_peptide_to_ic50_dict


def imputer_from_name(imputation_method_name, **kwargs):
    """
    Helper function for constructing an imputation object from a name given
    typically from a commandline argument.
    """
    imputation_method_name = imputation_method_name.strip().lower()
    if imputation_method_name == "mice":
        kwargs["n_burn_in"] = kwargs.get("n_burn_in", 5)
        kwargs["n_imputations"] = kwargs.get("n_imputations", 25)
        kwargs["n_nearest_columns"] = kwargs.get("n_nearest_columns", 25)
        return MICE(**kwargs)
    elif imputation_method_name == "knn":
        kwargs["k"] = kwargs.get("k", 3)
        kwargs["orientation"] = kwargs.get("orientation", "columns")
        kwargs["print_interval"] = kwargs.get("print_interval", 10)
        return KNN(**kwargs)
    elif imputation_method_name == "svd":
        kwargs["rank"] = kwargs.get("rank", 10)
        return IterativeSVD(**kwargs)
    elif imputation_method_name in ("svt", "softimpute"):
        kwargs["init_fill_method"] = kwargs.get("init_fill_method", "min")
        kwargs["normalizer"] = kwargs.get("normalizer", BiScaler())
        return SoftImpute(**kwargs)
    elif imputation_method_name == "mean":
        return SimpleFill("mean", **kwargs)
    elif imputation_method_name == "none":
        return None
    else:
        raise ValueError(
            "Invalid imputation method: %s" % imputation_method_name)

# Copyright (c) 2016. Mount Sinai School of Medicine
#
# Licensed under the Apache License, Version 2.0 (the "License");
# you may not use this file except in compliance with the License.
# You may obtain a copy of the License at
#
#     http://www.apache.org/licenses/LICENSE-2.0
#
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.

from __future__ import (
    print_function,
    division,
    absolute_import,
)
from collections import defaultdict

import numpy as np
from fancyimpute.knn import KNN
from fancyimpute.iterative_svd import IterativeSVD
from fancyimpute.simple_fill import SimpleFill
from fancyimpute.soft_impute import SoftImpute
from fancyimpute.mice import MICE
from fancyimpute.biscaler import BiScaler


def check_dense_pMHC_array(X, peptide_list, allele_list):
    if len(peptide_list) != len(set(peptide_list)):
        raise ValueError("Duplicate peptides detected in peptide list")
    if len(allele_list) != len(set(allele_list)):
        raise ValueError("Duplicate alleles detected in allele list")
    n_rows, n_cols = X.shape
    if n_rows != len(peptide_list):
        raise ValueError(
            "Expected dense array with shape %s to have %d rows" % (
                X.shape, len(peptide_list)))
    if n_cols != len(allele_list):
        raise ValueError(
            "Expected dense array with shape %s to have %d columns" % (
                X.shape, len(allele_list)))


def prune_dense_matrix_and_labels(
        X,
        peptide_list,
        allele_list,
        min_observations_per_peptide=1,
        min_observations_per_allele=1):
    """
    Filter the dense matrix of pMHC binding affinities according to
    the given minimum number of row/column observations.

    Parameters
    ----------
    X : numpy.ndarray
        Incomplete dense matrix of pMHC affinity with n_peptides rows and
        n_alleles columns.

    peptide_list : list of str
        Expected to have n_peptides entries

    allele_list : list of str
        Expected to have n_alleles entries

    min_observations_per_peptide : int
        Drop peptide rows with fewer than this number of observed values.

    min_observations_per_allele : int
        Drop allele columns with fewer than this number of observed values.
    """
    observed_mask = np.isfinite(X)
    n_observed_per_peptide = observed_mask.sum(axis=1)
    too_few_peptide_observations = (
        n_observed_per_peptide < min_observations_per_peptide)
    if too_few_peptide_observations.any():
        drop_peptide_indices = np.where(too_few_peptide_observations)[0]
        keep_peptide_indices = np.where(~too_few_peptide_observations)[0]
        print("Dropping %d peptides with <%d observations" % (
            len(drop_peptide_indices),
            min_observations_per_peptide))
        X = X[keep_peptide_indices]
        observed_mask = observed_mask[keep_peptide_indices]
        peptide_list = [peptide_list[i] for i in keep_peptide_indices]

    n_observed_per_allele = observed_mask.sum(axis=0)
    too_few_allele_observations = (
        n_observed_per_allele < min_observations_per_peptide)
    if too_few_peptide_observations.any():
        drop_allele_indices = np.where(too_few_allele_observations)[0]
        keep_allele_indices = np.where(~too_few_allele_observations)[0]
        print("Dropping %d alleles with <%d observations: %s" % (
            len(drop_allele_indices),
            min_observations_per_allele,
            [allele_list[i] for i in drop_allele_indices]))
        X = X[:, keep_allele_indices]
        observed_mask = observed_mask[:, keep_allele_indices]
        allele_list = [allele_list[i] for i in keep_allele_indices]
    check_dense_pMHC_array(X, peptide_list, allele_list)
    return X, peptide_list, allele_list


def dense_pMHC_matrix_to_nested_dict(X, peptide_list, allele_list):
    """
    Converts a dense matrix of (n_peptides, n_alleles) floats to a nested
    dictionary from allele -> peptide -> affinity.
    """
    allele_to_peptide_to_ic50_dict = defaultdict(dict)
    for row_index, peptide in enumerate(peptide_list):
        for column_index, allele_name in enumerate(allele_list):
            affinity = X[row_index, column_index]
            if np.isfinite(affinity):
                allele_to_peptide_to_ic50_dict[allele_name][peptide] = affinity
    return allele_to_peptide_to_ic50_dict


def imputer_from_name(imputation_method_name, **kwargs):
    """
    Helper function for constructing an imputation object from a name given
    typically from a commandline argument.
    """
    imputation_method_name = imputation_method_name.strip().lower()
    if imputation_method_name == "mice":
        kwargs["n_burn_in"] = kwargs.get("n_burn_in", 5)
        kwargs["n_imputations"] = kwargs.get("n_imputations", 25)
        kwargs["n_nearest_columns"] = kwargs.get("n_nearest_columns", 25)
        return MICE(**kwargs)
    elif imputation_method_name == "knn":
        kwargs["k"] = kwargs.get("k", 3)
        kwargs["orientation"] = kwargs.get("orientation", "columns")
        kwargs["print_interval"] = kwargs.get("print_interval", 10)
        return KNN(**kwargs)
    elif imputation_method_name == "svd":
        kwargs["rank"] = kwargs.get("rank", 10)
        return IterativeSVD(**kwargs)
    elif imputation_method_name in ("svt", "softimpute"):
        kwargs["init_fill_method"] = kwargs.get("init_fill_method", "min")
        kwargs["normalizer"] = kwargs.get("normalizer", BiScaler())
        return SoftImpute(**kwargs)
    elif imputation_method_name == "mean":
        return SimpleFill("mean", **kwargs)
    elif imputation_method_name == "none":
        return None
    else:
        raise ValueError(
            "Invalid imputation method: %s" % imputation_method_name)

# Copyright (c) 2016. Mount Sinai School of Medicine # # Licensed under the Apache License, Version 2.0 (the "License"); # you may not use this file except in compliance with the License. # You may obtain a copy of the License at # #     http://www.apache.org/licenses/LICENSE-2.0 # # Unless required by applicable law or agreed to in writing, software # distributed under the License is distributed on an "AS IS" BASIS, # WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. # See the License for the specific language governing permissions and # limitations under the License. Filter the dense matrix of pMHC binding affinities according to     the given minimum number of row/column observations.      Parameters     ----------     X : numpy.ndarray         Incomplete dense matrix of pMHC affinity with n_peptides rows and         n_alleles columns.      peptide_list : list of str         Expected to have n_peptides entries      allele_list : list of str         Expected to have n_alleles entries      min_observations_per_peptide : int         Drop peptide rows with fewer than this number of observed values.      min_observations_per_allele : int         Drop allele columns with fewer than this number of observed values. Converts a dense matrix of (n_peptides, n_alleles) floats to a nested     dictionary from allele -> peptide -> affinity. Helper function for constructing an imputation object from a name given     typically from a commandline argument.