IanL10/Genomic-text · Datasets at Hugging Face

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Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease. ### Output: The disease is Peripheral Nervous System Diseases.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity IGF1 and disease Peripheral Nervous System Diseases. ### Input: description Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease. ### Output: The relation type is therapeutic.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Protoporphyrinogen oxidase activity and ferrochelatase activity have been measured in blood lymphocytes from patients with prophyria variegata, and from some members of the family of one patient; the mean activity of protoporphyrinogen oxidase from patients was about 50% of that in lymphocytes from normal subjects; similar results were obtained from asymptomatic carriers in two generations of the patient's family. ### Output: The gene entity is PPOX.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Protoporphyrinogen oxidase activity and ferrochelatase activity have been measured in blood lymphocytes from patients with prophyria variegata, and from some members of the family of one patient; the mean activity of protoporphyrinogen oxidase from patients was about 50% of that in lymphocytes from normal subjects; similar results were obtained from asymptomatic carriers in two generations of the patient's family. ### Output: The disease is Asymptomatic.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity PPOX and disease Asymptomatic. ### Input: description Protoporphyrinogen oxidase activity and ferrochelatase activity have been measured in blood lymphocytes from patients with prophyria variegata, and from some members of the family of one patient; the mean activity of protoporphyrinogen oxidase from patients was about 50% of that in lymphocytes from normal subjects; similar results were obtained from asymptomatic carriers in two generations of the patient's family. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description BCL1/PRAD1 is the gene locus involved in the t(11;14)(q13;q32) translocation, which often occurs in a proposed subtype of non-Hodgkin's lymphoma of B-cell phenotype (B-NHL), named mantle cell lymphoma (MCL). ### Output: The gene entity is CCND1.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description BCL1/PRAD1 is the gene locus involved in the t(11;14)(q13;q32) translocation, which often occurs in a proposed subtype of non-Hodgkin's lymphoma of B-cell phenotype (B-NHL), named mantle cell lymphoma (MCL). ### Output: The disease is Chromosomal translocation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CCND1 and disease Chromosomal translocation. ### Input: description BCL1/PRAD1 is the gene locus involved in the t(11;14)(q13;q32) translocation, which often occurs in a proposed subtype of non-Hodgkin's lymphoma of B-cell phenotype (B-NHL), named mantle cell lymphoma (MCL). ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Western blot analysis indicated that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway was involved in the mechanisms underlying the in vitro and in vivo inhibitory effects of SIM on cardiac hypertrophy. ### Output: The gene entity is SIM2.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Western blot analysis indicated that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway was involved in the mechanisms underlying the in vitro and in vivo inhibitory effects of SIM on cardiac hypertrophy. ### Output: The disease is Cardiac Hypertrophy.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity SIM2 and disease Cardiac Hypertrophy. ### Input: description Western blot analysis indicated that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway was involved in the mechanisms underlying the in vitro and in vivo inhibitory effects of SIM on cardiac hypertrophy. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description CtBP2 is an ovarian cancer oncogene that may play a significant role in epigenetically silencing BRCA1 function in sporadic epithelial ovarian cancer. ### Output: The gene entity is BRCA1.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description CtBP2 is an ovarian cancer oncogene that may play a significant role in epigenetically silencing BRCA1 function in sporadic epithelial ovarian cancer. ### Output: The disease is Isolated cases.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity BRCA1 and disease Isolated cases. ### Input: description CtBP2 is an ovarian cancer oncogene that may play a significant role in epigenetically silencing BRCA1 function in sporadic epithelial ovarian cancer. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description hMOF, but not HDAC4, is mainly responsible for global histone H4K16ac acetylation in gastric cancer cells. ### Output: The gene entity is KAT8.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description hMOF, but not HDAC4, is mainly responsible for global histone H4K16ac acetylation in gastric cancer cells. ### Output: The disease is Malignant neoplasm of stomach.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity KAT8 and disease Malignant neoplasm of stomach. ### Input: description hMOF, but not HDAC4, is mainly responsible for global histone H4K16ac acetylation in gastric cancer cells. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Liver biopsies were performed on 20 chronically HBV-infected (15 HBeAg-positive and 5 HBeAg-negative) patients to assess liver inflammation/fibrosis, and mRNA levels of furin, IL-10, IL-12β, IFN-γ, PD-1, and PD-L1 were assessed by quantitative real-time PCR. ### Output: The gene entity is IFNA1.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Liver biopsies were performed on 20 chronically HBV-infected (15 HBeAg-positive and 5 HBeAg-negative) patients to assess liver inflammation/fibrosis, and mRNA levels of furin, IL-10, IL-12β, IFN-γ, PD-1, and PD-L1 were assessed by quantitative real-time PCR. ### Output: The disease is Fibrosis.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity IFNA1 and disease Fibrosis. ### Input: description Liver biopsies were performed on 20 chronically HBV-infected (15 HBeAg-positive and 5 HBeAg-negative) patients to assess liver inflammation/fibrosis, and mRNA levels of furin, IL-10, IL-12β, IFN-γ, PD-1, and PD-L1 were assessed by quantitative real-time PCR. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description The association of rare chromosomal rearrangements involving a specific 17q breakpoint with campomelic syndrome (CMPS) and/or sex reversal (SR) has led to an assignment of the CMPS1/SRA1 locus to 17q24.3-->q25.1. ### Output: The gene entity is CYFIP1.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description The association of rare chromosomal rearrangements involving a specific 17q breakpoint with campomelic syndrome (CMPS) and/or sex reversal (SR) has led to an assignment of the CMPS1/SRA1 locus to 17q24.3-->q25.1. ### Output: The disease is Sex reversal.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CYFIP1 and disease Sex reversal. ### Input: description The association of rare chromosomal rearrangements involving a specific 17q breakpoint with campomelic syndrome (CMPS) and/or sex reversal (SR) has led to an assignment of the CMPS1/SRA1 locus to 17q24.3-->q25.1. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Based on the hypothesis that abnormalities of innate immune responses are involved in carcinogenesis, we examined the presence or absence of the expression of Toll-like receptor 4 (TLR4), comprising one of the TLR families, in colorectal cancer tissues. ### Output: The gene entity is TLR4.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Based on the hypothesis that abnormalities of innate immune responses are involved in carcinogenesis, we examined the presence or absence of the expression of Toll-like receptor 4 (TLR4), comprising one of the TLR families, in colorectal cancer tissues. ### Output: The disease is Congenital Abnormality.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity TLR4 and disease Congenital Abnormality. ### Input: description Based on the hypothesis that abnormalities of innate immune responses are involved in carcinogenesis, we examined the presence or absence of the expression of Toll-like receptor 4 (TLR4), comprising one of the TLR families, in colorectal cancer tissues. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description To undertake analysis of hepatitis A viral load, alanine aminotransferase (ALT), and viral genotypes with duration of viremia, and to correlate these parameters with CD4(+)/ CD8(+) lymphocyte populations that control cell-mediated immunity. ### Output: The gene entity is GPT.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description To undertake analysis of hepatitis A viral load, alanine aminotransferase (ALT), and viral genotypes with duration of viremia, and to correlate these parameters with CD4(+)/ CD8(+) lymphocyte populations that control cell-mediated immunity. ### Output: The disease is Viral Load result.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity GPT and disease Viral Load result. ### Input: description To undertake analysis of hepatitis A viral load, alanine aminotransferase (ALT), and viral genotypes with duration of viremia, and to correlate these parameters with CD4(+)/ CD8(+) lymphocyte populations that control cell-mediated immunity. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Inhibition of MIR21, MIR23A, and MIR27A had synergistic effects in reducing proliferation of PDAC cells in culture and growth of xenograft tumors in mice. ### Output: The gene entity is MIR27A.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Inhibition of MIR21, MIR23A, and MIR27A had synergistic effects in reducing proliferation of PDAC cells in culture and growth of xenograft tumors in mice. ### Output: The disease is Neoplasms.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity MIR27A and disease Neoplasms. ### Input: description Inhibition of MIR21, MIR23A, and MIR27A had synergistic effects in reducing proliferation of PDAC cells in culture and growth of xenograft tumors in mice. ### Output: The relation type is biomarker.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description ]ryanodine binding sites (Bmax) and the expression levels of ryanodine receptor (RyR) mRNA and calcium-adenosine triphosphatase (Ca2+-ATPase) mRNA in atrial myocardial tissue from 13 patients with AF due to mitral valvular disease (MVD) and 9 patients with normal sinus rhythm (NSR). ### Output: The gene entity is MVD.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description ]ryanodine binding sites (Bmax) and the expression levels of ryanodine receptor (RyR) mRNA and calcium-adenosine triphosphatase (Ca2+-ATPase) mRNA in atrial myocardial tissue from 13 patients with AF due to mitral valvular disease (MVD) and 9 patients with normal sinus rhythm (NSR). ### Output: The disease is Diseases of mitral valve.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity MVD and disease Diseases of mitral valve. ### Input: description ]ryanodine binding sites (Bmax) and the expression levels of ryanodine receptor (RyR) mRNA and calcium-adenosine triphosphatase (Ca2+-ATPase) mRNA in atrial myocardial tissue from 13 patients with AF due to mitral valvular disease (MVD) and 9 patients with normal sinus rhythm (NSR). ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test: P = 0.06). ### Output: The gene entity is TP53.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test: P = 0.06). ### Output: The disease is Smoking.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity TP53 and disease Smoking. ### Input: description However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test: P = 0.06). ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. ### Output: The gene entity is FGF2.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. ### Output: The disease is Jacksonian Seizure.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity FGF2 and disease Jacksonian Seizure. ### Input: description Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. ### Output: The relation type is therapeutic.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Central to the molecular pathogenesis of HCC are mutations of various genes and genetic/chromosomal instability that result from chronic liver disease and the associated enhanced liver cell regeneration and mitotic activity. ### Output: The gene entity is FAM126A.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Central to the molecular pathogenesis of HCC are mutations of various genes and genetic/chromosomal instability that result from chronic liver disease and the associated enhanced liver cell regeneration and mitotic activity. ### Output: The disease is Chromosomal Instability.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity FAM126A and disease Chromosomal Instability. ### Input: description Central to the molecular pathogenesis of HCC are mutations of various genes and genetic/chromosomal instability that result from chronic liver disease and the associated enhanced liver cell regeneration and mitotic activity. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Taking into account the available data, pretreated NSCLC patients carrying the ALK-translocation require a selected targeted therapy which significantly improves activity, efficacy and symptoms control versus chemotherapy. ### Output: The gene entity is ALK.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Taking into account the available data, pretreated NSCLC patients carrying the ALK-translocation require a selected targeted therapy which significantly improves activity, efficacy and symptoms control versus chemotherapy. ### Output: The disease is Chromosomal translocation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity ALK and disease Chromosomal translocation. ### Input: description Taking into account the available data, pretreated NSCLC patients carrying the ALK-translocation require a selected targeted therapy which significantly improves activity, efficacy and symptoms control versus chemotherapy. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. ### Output: The gene entity is PDGFRB.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. ### Output: The disease is Eosinophilic disorder.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity PDGFRB and disease Eosinophilic disorder. ### Input: description Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. ### Output: The relation type is genomic_alterations.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In present study, functional and mechanism experiments were conducted to investigate the role of long intergenic non-protein coding RNA 00858 (LINC00858) on human osteosarcoma tumorigenesis. ### Output: The gene entity is LINC00858.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In present study, functional and mechanism experiments were conducted to investigate the role of long intergenic non-protein coding RNA 00858 (LINC00858) on human osteosarcoma tumorigenesis. ### Output: The disease is Carcinogenesis.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity LINC00858 and disease Carcinogenesis. ### Input: description In present study, functional and mechanism experiments were conducted to investigate the role of long intergenic non-protein coding RNA 00858 (LINC00858) on human osteosarcoma tumorigenesis. ### Output: The relation type is biomarker.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Lentiviral-mediated transduction of VE-cadherin and PECAM-1 into REH cells and antibody neutralization of VE-cadherin and PECAM-1 in SUP-B15 cells was used to delineate the role of these two proteins in mediating ALL adhesion to, and migration through, HBMEC monolayers. ### Output: The gene entity is HERPUD1.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Lentiviral-mediated transduction of VE-cadherin and PECAM-1 into REH cells and antibody neutralization of VE-cadherin and PECAM-1 in SUP-B15 cells was used to delineate the role of these two proteins in mediating ALL adhesion to, and migration through, HBMEC monolayers. ### Output: The disease is Tissue Adhesions.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity HERPUD1 and disease Tissue Adhesions. ### Input: description Lentiviral-mediated transduction of VE-cadherin and PECAM-1 into REH cells and antibody neutralization of VE-cadherin and PECAM-1 in SUP-B15 cells was used to delineate the role of these two proteins in mediating ALL adhesion to, and migration through, HBMEC monolayers. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness. ### Output: The gene entity is DAPK1.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness. ### Output: The disease is Hypoxia.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity DAPK1 and disease Hypoxia. ### Input: description miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description The ACE genotypes did not differ in terms of age, sex, body mass index, blood pressure, plasma lipids or lipoproteins. ### Output: The gene entity is ACE.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description The ACE genotypes did not differ in terms of age, sex, body mass index, blood pressure, plasma lipids or lipoproteins. ### Output: The disease is Body mass index.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity ACE and disease Body mass index. ### Input: description The ACE genotypes did not differ in terms of age, sex, body mass index, blood pressure, plasma lipids or lipoproteins. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Recently, the adenosine A2A receptor (A2AR) emerges as a novel inflammation regulator, therefore manipulation of A2AR may suppress the EMT process and as such protect against RIF. ### Output: The gene entity is ADORA2A.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Recently, the adenosine A2A receptor (A2AR) emerges as a novel inflammation regulator, therefore manipulation of A2AR may suppress the EMT process and as such protect against RIF. ### Output: The disease is Inflammation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity ADORA2A and disease Inflammation. ### Input: description Recently, the adenosine A2A receptor (A2AR) emerges as a novel inflammation regulator, therefore manipulation of A2AR may suppress the EMT process and as such protect against RIF. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. ### Output: The gene entity is GRIA3.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. ### Output: The disease is Feeling suicidal (finding).
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity GRIA3 and disease Feeling suicidal (finding). ### Input: description Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In conclusion, these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. ### Output: The gene entity is GLYAT.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In conclusion, these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. ### Output: The disease is Neuralgia.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity GLYAT and disease Neuralgia. ### Input: description In conclusion, these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In additional, HNSCC tumor tissue was analyzed to determine whether the wild-type p16 allele was lost or maintained. ### Output: The gene entity is CDKN2A.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In additional, HNSCC tumor tissue was analyzed to determine whether the wild-type p16 allele was lost or maintained. ### Output: The disease is Neoplasms.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CDKN2A and disease Neoplasms. ### Input: description In additional, HNSCC tumor tissue was analyzed to determine whether the wild-type p16 allele was lost or maintained. ### Output: The relation type is genomic_alterations.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Stromal cell-derived factor 1α (SDF-1α) and its receptor, CXC chemokine receptor 4 (CXCR4), has been implicated as a regulator of bone resorption, suggesting that agents that can suppress SDF1α/CXCR4 signaling might inhibit osteoclastogenesis, a process closely linked to bone resorption. ### Output: The gene entity is CXCR4.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Stromal cell-derived factor 1α (SDF-1α) and its receptor, CXC chemokine receptor 4 (CXCR4), has been implicated as a regulator of bone resorption, suggesting that agents that can suppress SDF1α/CXCR4 signaling might inhibit osteoclastogenesis, a process closely linked to bone resorption. ### Output: The disease is Bone Resorption.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CXCR4 and disease Bone Resorption. ### Input: description Stromal cell-derived factor 1α (SDF-1α) and its receptor, CXC chemokine receptor 4 (CXCR4), has been implicated as a regulator of bone resorption, suggesting that agents that can suppress SDF1α/CXCR4 signaling might inhibit osteoclastogenesis, a process closely linked to bone resorption. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR). ### Output: The gene entity is AGT.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR). ### Output: The disease is Lower Urinary Tract Symptoms.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity AGT and disease Lower Urinary Tract Symptoms. ### Input: description As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR). ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Splicing abnormalities of CHCHD2 mutants were analysed in SH-SY5Y cells. ### Output: The gene entity is CHCHD2.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Splicing abnormalities of CHCHD2 mutants were analysed in SH-SY5Y cells. ### Output: The disease is Congenital Abnormality.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CHCHD2 and disease Congenital Abnormality. ### Input: description Splicing abnormalities of CHCHD2 mutants were analysed in SH-SY5Y cells. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In order to address a potential role of the interaction of p53 with MDM2 for the regulation of cellularity in atherosclerotic tissue, 22 carotid atheromatous plaques from patients undergoing endarterectomy were studied to determine the presence of p53 immunoreactivity (IR), MDM2 IR, cell proliferation as evidenced by MIB1/Ki-67 IR and DNA fragmentation by in situ terminal transferase-mediated dUTP 3' end labelling (TUNEL), as a marker for apoptosis. ### Output: The gene entity is TP53.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In order to address a potential role of the interaction of p53 with MDM2 for the regulation of cellularity in atherosclerotic tissue, 22 carotid atheromatous plaques from patients undergoing endarterectomy were studied to determine the presence of p53 immunoreactivity (IR), MDM2 IR, cell proliferation as evidenced by MIB1/Ki-67 IR and DNA fragmentation by in situ terminal transferase-mediated dUTP 3' end labelling (TUNEL), as a marker for apoptosis. ### Output: The disease is Atheroma.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity TP53 and disease Atheroma. ### Input: description In order to address a potential role of the interaction of p53 with MDM2 for the regulation of cellularity in atherosclerotic tissue, 22 carotid atheromatous plaques from patients undergoing endarterectomy were studied to determine the presence of p53 immunoreactivity (IR), MDM2 IR, cell proliferation as evidenced by MIB1/Ki-67 IR and DNA fragmentation by in situ terminal transferase-mediated dUTP 3' end labelling (TUNEL), as a marker for apoptosis. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In this study, we examined the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR. ### Output: The gene entity is HOTAIR.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In this study, we examined the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR. ### Output: The disease is Metastatic malignant neoplasm to brain.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity HOTAIR and disease Metastatic malignant neoplasm to brain. ### Input: description In this study, we examined the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR. ### Output: No relation.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description These results suggest that the HLA-G 14-bp insertion/deletion polymorphism may not be associated with HCC susceptibility and liver cirrhosis development in the Korean population. ### Output: The gene entity is HLA-G.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description These results suggest that the HLA-G 14-bp insertion/deletion polymorphism may not be associated with HCC susceptibility and liver cirrhosis development in the Korean population. ### Output: The disease is Liver Cirrhosis.
Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity HLA-G and disease Liver Cirrhosis. ### Input: description These results suggest that the HLA-G 14-bp insertion/deletion polymorphism may not be associated with HCC susceptibility and liver cirrhosis development in the Korean population. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease. ### Output: The disease is Peripheral Nervous System Diseases.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity IGF1 and disease Peripheral Nervous System Diseases. ### Input: description Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease. ### Output: The relation type is therapeutic.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Protoporphyrinogen oxidase activity and ferrochelatase activity have been measured in blood lymphocytes from patients with prophyria variegata, and from some members of the family of one patient; the mean activity of protoporphyrinogen oxidase from patients was about 50% of that in lymphocytes from normal subjects; similar results were obtained from asymptomatic carriers in two generations of the patient's family. ### Output: The gene entity is PPOX.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Protoporphyrinogen oxidase activity and ferrochelatase activity have been measured in blood lymphocytes from patients with prophyria variegata, and from some members of the family of one patient; the mean activity of protoporphyrinogen oxidase from patients was about 50% of that in lymphocytes from normal subjects; similar results were obtained from asymptomatic carriers in two generations of the patient's family. ### Output: The disease is Asymptomatic.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity PPOX and disease Asymptomatic. ### Input: description Protoporphyrinogen oxidase activity and ferrochelatase activity have been measured in blood lymphocytes from patients with prophyria variegata, and from some members of the family of one patient; the mean activity of protoporphyrinogen oxidase from patients was about 50% of that in lymphocytes from normal subjects; similar results were obtained from asymptomatic carriers in two generations of the patient's family. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description BCL1/PRAD1 is the gene locus involved in the t(11;14)(q13;q32) translocation, which often occurs in a proposed subtype of non-Hodgkin's lymphoma of B-cell phenotype (B-NHL), named mantle cell lymphoma (MCL). ### Output: The gene entity is CCND1.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description BCL1/PRAD1 is the gene locus involved in the t(11;14)(q13;q32) translocation, which often occurs in a proposed subtype of non-Hodgkin's lymphoma of B-cell phenotype (B-NHL), named mantle cell lymphoma (MCL). ### Output: The disease is Chromosomal translocation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CCND1 and disease Chromosomal translocation. ### Input: description BCL1/PRAD1 is the gene locus involved in the t(11;14)(q13;q32) translocation, which often occurs in a proposed subtype of non-Hodgkin's lymphoma of B-cell phenotype (B-NHL), named mantle cell lymphoma (MCL). ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Western blot analysis indicated that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway was involved in the mechanisms underlying the in vitro and in vivo inhibitory effects of SIM on cardiac hypertrophy. ### Output: The gene entity is SIM2.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Western blot analysis indicated that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway was involved in the mechanisms underlying the in vitro and in vivo inhibitory effects of SIM on cardiac hypertrophy. ### Output: The disease is Cardiac Hypertrophy.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity SIM2 and disease Cardiac Hypertrophy. ### Input: description Western blot analysis indicated that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway was involved in the mechanisms underlying the in vitro and in vivo inhibitory effects of SIM on cardiac hypertrophy. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description CtBP2 is an ovarian cancer oncogene that may play a significant role in epigenetically silencing BRCA1 function in sporadic epithelial ovarian cancer. ### Output: The gene entity is BRCA1.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description CtBP2 is an ovarian cancer oncogene that may play a significant role in epigenetically silencing BRCA1 function in sporadic epithelial ovarian cancer. ### Output: The disease is Isolated cases.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity BRCA1 and disease Isolated cases. ### Input: description CtBP2 is an ovarian cancer oncogene that may play a significant role in epigenetically silencing BRCA1 function in sporadic epithelial ovarian cancer. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description hMOF, but not HDAC4, is mainly responsible for global histone H4K16ac acetylation in gastric cancer cells. ### Output: The gene entity is KAT8.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description hMOF, but not HDAC4, is mainly responsible for global histone H4K16ac acetylation in gastric cancer cells. ### Output: The disease is Malignant neoplasm of stomach.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity KAT8 and disease Malignant neoplasm of stomach. ### Input: description hMOF, but not HDAC4, is mainly responsible for global histone H4K16ac acetylation in gastric cancer cells. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Liver biopsies were performed on 20 chronically HBV-infected (15 HBeAg-positive and 5 HBeAg-negative) patients to assess liver inflammation/fibrosis, and mRNA levels of furin, IL-10, IL-12β, IFN-γ, PD-1, and PD-L1 were assessed by quantitative real-time PCR. ### Output: The gene entity is IFNA1.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Liver biopsies were performed on 20 chronically HBV-infected (15 HBeAg-positive and 5 HBeAg-negative) patients to assess liver inflammation/fibrosis, and mRNA levels of furin, IL-10, IL-12β, IFN-γ, PD-1, and PD-L1 were assessed by quantitative real-time PCR. ### Output: The disease is Fibrosis.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity IFNA1 and disease Fibrosis. ### Input: description Liver biopsies were performed on 20 chronically HBV-infected (15 HBeAg-positive and 5 HBeAg-negative) patients to assess liver inflammation/fibrosis, and mRNA levels of furin, IL-10, IL-12β, IFN-γ, PD-1, and PD-L1 were assessed by quantitative real-time PCR. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description The association of rare chromosomal rearrangements involving a specific 17q breakpoint with campomelic syndrome (CMPS) and/or sex reversal (SR) has led to an assignment of the CMPS1/SRA1 locus to 17q24.3-->q25.1. ### Output: The gene entity is CYFIP1.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description The association of rare chromosomal rearrangements involving a specific 17q breakpoint with campomelic syndrome (CMPS) and/or sex reversal (SR) has led to an assignment of the CMPS1/SRA1 locus to 17q24.3-->q25.1. ### Output: The disease is Sex reversal.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CYFIP1 and disease Sex reversal. ### Input: description The association of rare chromosomal rearrangements involving a specific 17q breakpoint with campomelic syndrome (CMPS) and/or sex reversal (SR) has led to an assignment of the CMPS1/SRA1 locus to 17q24.3-->q25.1. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Based on the hypothesis that abnormalities of innate immune responses are involved in carcinogenesis, we examined the presence or absence of the expression of Toll-like receptor 4 (TLR4), comprising one of the TLR families, in colorectal cancer tissues. ### Output: The gene entity is TLR4.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Based on the hypothesis that abnormalities of innate immune responses are involved in carcinogenesis, we examined the presence or absence of the expression of Toll-like receptor 4 (TLR4), comprising one of the TLR families, in colorectal cancer tissues. ### Output: The disease is Congenital Abnormality.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity TLR4 and disease Congenital Abnormality. ### Input: description Based on the hypothesis that abnormalities of innate immune responses are involved in carcinogenesis, we examined the presence or absence of the expression of Toll-like receptor 4 (TLR4), comprising one of the TLR families, in colorectal cancer tissues. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description To undertake analysis of hepatitis A viral load, alanine aminotransferase (ALT), and viral genotypes with duration of viremia, and to correlate these parameters with CD4(+)/ CD8(+) lymphocyte populations that control cell-mediated immunity. ### Output: The gene entity is GPT.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description To undertake analysis of hepatitis A viral load, alanine aminotransferase (ALT), and viral genotypes with duration of viremia, and to correlate these parameters with CD4(+)/ CD8(+) lymphocyte populations that control cell-mediated immunity. ### Output: The disease is Viral Load result.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity GPT and disease Viral Load result. ### Input: description To undertake analysis of hepatitis A viral load, alanine aminotransferase (ALT), and viral genotypes with duration of viremia, and to correlate these parameters with CD4(+)/ CD8(+) lymphocyte populations that control cell-mediated immunity. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Inhibition of MIR21, MIR23A, and MIR27A had synergistic effects in reducing proliferation of PDAC cells in culture and growth of xenograft tumors in mice. ### Output: The gene entity is MIR27A.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Inhibition of MIR21, MIR23A, and MIR27A had synergistic effects in reducing proliferation of PDAC cells in culture and growth of xenograft tumors in mice. ### Output: The disease is Neoplasms.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity MIR27A and disease Neoplasms. ### Input: description Inhibition of MIR21, MIR23A, and MIR27A had synergistic effects in reducing proliferation of PDAC cells in culture and growth of xenograft tumors in mice. ### Output: The relation type is biomarker.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description ]ryanodine binding sites (Bmax) and the expression levels of ryanodine receptor (RyR) mRNA and calcium-adenosine triphosphatase (Ca2+-ATPase) mRNA in atrial myocardial tissue from 13 patients with AF due to mitral valvular disease (MVD) and 9 patients with normal sinus rhythm (NSR). ### Output: The gene entity is MVD.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description ]ryanodine binding sites (Bmax) and the expression levels of ryanodine receptor (RyR) mRNA and calcium-adenosine triphosphatase (Ca2+-ATPase) mRNA in atrial myocardial tissue from 13 patients with AF due to mitral valvular disease (MVD) and 9 patients with normal sinus rhythm (NSR). ### Output: The disease is Diseases of mitral valve.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity MVD and disease Diseases of mitral valve. ### Input: description ]ryanodine binding sites (Bmax) and the expression levels of ryanodine receptor (RyR) mRNA and calcium-adenosine triphosphatase (Ca2+-ATPase) mRNA in atrial myocardial tissue from 13 patients with AF due to mitral valvular disease (MVD) and 9 patients with normal sinus rhythm (NSR). ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test: P = 0.06). ### Output: The gene entity is TP53.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test: P = 0.06). ### Output: The disease is Smoking.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity TP53 and disease Smoking. ### Input: description However, a trend for total pack-years of smoking was found when p53-positive cases were compared with p53-negative cases suggesting aetiological, heterogeneity (trend test: P = 0.06). ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. ### Output: The gene entity is FGF2.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. ### Output: The disease is Jacksonian Seizure.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity FGF2 and disease Jacksonian Seizure. ### Input: description Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. ### Output: The relation type is therapeutic.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Central to the molecular pathogenesis of HCC are mutations of various genes and genetic/chromosomal instability that result from chronic liver disease and the associated enhanced liver cell regeneration and mitotic activity. ### Output: The gene entity is FAM126A.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Central to the molecular pathogenesis of HCC are mutations of various genes and genetic/chromosomal instability that result from chronic liver disease and the associated enhanced liver cell regeneration and mitotic activity. ### Output: The disease is Chromosomal Instability.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity FAM126A and disease Chromosomal Instability. ### Input: description Central to the molecular pathogenesis of HCC are mutations of various genes and genetic/chromosomal instability that result from chronic liver disease and the associated enhanced liver cell regeneration and mitotic activity. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Taking into account the available data, pretreated NSCLC patients carrying the ALK-translocation require a selected targeted therapy which significantly improves activity, efficacy and symptoms control versus chemotherapy. ### Output: The gene entity is ALK.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Taking into account the available data, pretreated NSCLC patients carrying the ALK-translocation require a selected targeted therapy which significantly improves activity, efficacy and symptoms control versus chemotherapy. ### Output: The disease is Chromosomal translocation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity ALK and disease Chromosomal translocation. ### Input: description Taking into account the available data, pretreated NSCLC patients carrying the ALK-translocation require a selected targeted therapy which significantly improves activity, efficacy and symptoms control versus chemotherapy. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. ### Output: The gene entity is PDGFRB.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. ### Output: The disease is Eosinophilic disorder.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity PDGFRB and disease Eosinophilic disorder. ### Input: description Although patients with PDGFRB rearrangement mostly present with myeloproliferative neoplasm and eosinophilia, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have also been reported in this population. ### Output: The relation type is genomic_alterations.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In present study, functional and mechanism experiments were conducted to investigate the role of long intergenic non-protein coding RNA 00858 (LINC00858) on human osteosarcoma tumorigenesis. ### Output: The gene entity is LINC00858.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In present study, functional and mechanism experiments were conducted to investigate the role of long intergenic non-protein coding RNA 00858 (LINC00858) on human osteosarcoma tumorigenesis. ### Output: The disease is Carcinogenesis.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity LINC00858 and disease Carcinogenesis. ### Input: description In present study, functional and mechanism experiments were conducted to investigate the role of long intergenic non-protein coding RNA 00858 (LINC00858) on human osteosarcoma tumorigenesis. ### Output: The relation type is biomarker.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Lentiviral-mediated transduction of VE-cadherin and PECAM-1 into REH cells and antibody neutralization of VE-cadherin and PECAM-1 in SUP-B15 cells was used to delineate the role of these two proteins in mediating ALL adhesion to, and migration through, HBMEC monolayers. ### Output: The gene entity is HERPUD1.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Lentiviral-mediated transduction of VE-cadherin and PECAM-1 into REH cells and antibody neutralization of VE-cadherin and PECAM-1 in SUP-B15 cells was used to delineate the role of these two proteins in mediating ALL adhesion to, and migration through, HBMEC monolayers. ### Output: The disease is Tissue Adhesions.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity HERPUD1 and disease Tissue Adhesions. ### Input: description Lentiviral-mediated transduction of VE-cadherin and PECAM-1 into REH cells and antibody neutralization of VE-cadherin and PECAM-1 in SUP-B15 cells was used to delineate the role of these two proteins in mediating ALL adhesion to, and migration through, HBMEC monolayers. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness. ### Output: The gene entity is DAPK1.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness. ### Output: The disease is Hypoxia.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity DAPK1 and disease Hypoxia. ### Input: description miR-103/107 expression was increased in the presence of hypoxia, thereby potentiating DAPK and KLF4 downregulation and hypoxia-induced motility and invasiveness. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description The ACE genotypes did not differ in terms of age, sex, body mass index, blood pressure, plasma lipids or lipoproteins. ### Output: The gene entity is ACE.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description The ACE genotypes did not differ in terms of age, sex, body mass index, blood pressure, plasma lipids or lipoproteins. ### Output: The disease is Body mass index.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity ACE and disease Body mass index. ### Input: description The ACE genotypes did not differ in terms of age, sex, body mass index, blood pressure, plasma lipids or lipoproteins. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Recently, the adenosine A2A receptor (A2AR) emerges as a novel inflammation regulator, therefore manipulation of A2AR may suppress the EMT process and as such protect against RIF. ### Output: The gene entity is ADORA2A.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Recently, the adenosine A2A receptor (A2AR) emerges as a novel inflammation regulator, therefore manipulation of A2AR may suppress the EMT process and as such protect against RIF. ### Output: The disease is Inflammation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity ADORA2A and disease Inflammation. ### Input: description Recently, the adenosine A2A receptor (A2AR) emerges as a novel inflammation regulator, therefore manipulation of A2AR may suppress the EMT process and as such protect against RIF. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. ### Output: The gene entity is GRIA3.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. ### Output: The disease is Feeling suicidal (finding).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity GRIA3 and disease Feeling suicidal (finding). ### Input: description Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In conclusion, these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. ### Output: The gene entity is GLYAT.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In conclusion, these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. ### Output: The disease is Neuralgia.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity GLYAT and disease Neuralgia. ### Input: description In conclusion, these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In additional, HNSCC tumor tissue was analyzed to determine whether the wild-type p16 allele was lost or maintained. ### Output: The gene entity is CDKN2A.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In additional, HNSCC tumor tissue was analyzed to determine whether the wild-type p16 allele was lost or maintained. ### Output: The disease is Neoplasms.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CDKN2A and disease Neoplasms. ### Input: description In additional, HNSCC tumor tissue was analyzed to determine whether the wild-type p16 allele was lost or maintained. ### Output: The relation type is genomic_alterations.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Stromal cell-derived factor 1α (SDF-1α) and its receptor, CXC chemokine receptor 4 (CXCR4), has been implicated as a regulator of bone resorption, suggesting that agents that can suppress SDF1α/CXCR4 signaling might inhibit osteoclastogenesis, a process closely linked to bone resorption. ### Output: The gene entity is CXCR4.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Stromal cell-derived factor 1α (SDF-1α) and its receptor, CXC chemokine receptor 4 (CXCR4), has been implicated as a regulator of bone resorption, suggesting that agents that can suppress SDF1α/CXCR4 signaling might inhibit osteoclastogenesis, a process closely linked to bone resorption. ### Output: The disease is Bone Resorption.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CXCR4 and disease Bone Resorption. ### Input: description Stromal cell-derived factor 1α (SDF-1α) and its receptor, CXC chemokine receptor 4 (CXCR4), has been implicated as a regulator of bone resorption, suggesting that agents that can suppress SDF1α/CXCR4 signaling might inhibit osteoclastogenesis, a process closely linked to bone resorption. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR). ### Output: The gene entity is AGT.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR). ### Output: The disease is Lower Urinary Tract Symptoms.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity AGT and disease Lower Urinary Tract Symptoms. ### Input: description As hypertension (HT) is one of the risk factors for lower urinary tract symptoms, we investigated the effect of an angiotensin II type I receptor blocker, olmesartan, on bladder dysfunction in the spontaneously hypertensive rat (SHR). ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description Splicing abnormalities of CHCHD2 mutants were analysed in SH-SY5Y cells. ### Output: The gene entity is CHCHD2.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description Splicing abnormalities of CHCHD2 mutants were analysed in SH-SY5Y cells. ### Output: The disease is Congenital Abnormality.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity CHCHD2 and disease Congenital Abnormality. ### Input: description Splicing abnormalities of CHCHD2 mutants were analysed in SH-SY5Y cells. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In order to address a potential role of the interaction of p53 with MDM2 for the regulation of cellularity in atherosclerotic tissue, 22 carotid atheromatous plaques from patients undergoing endarterectomy were studied to determine the presence of p53 immunoreactivity (IR), MDM2 IR, cell proliferation as evidenced by MIB1/Ki-67 IR and DNA fragmentation by in situ terminal transferase-mediated dUTP 3' end labelling (TUNEL), as a marker for apoptosis. ### Output: The gene entity is TP53.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In order to address a potential role of the interaction of p53 with MDM2 for the regulation of cellularity in atherosclerotic tissue, 22 carotid atheromatous plaques from patients undergoing endarterectomy were studied to determine the presence of p53 immunoreactivity (IR), MDM2 IR, cell proliferation as evidenced by MIB1/Ki-67 IR and DNA fragmentation by in situ terminal transferase-mediated dUTP 3' end labelling (TUNEL), as a marker for apoptosis. ### Output: The disease is Atheroma.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity TP53 and disease Atheroma. ### Input: description In order to address a potential role of the interaction of p53 with MDM2 for the regulation of cellularity in atherosclerotic tissue, 22 carotid atheromatous plaques from patients undergoing endarterectomy were studied to determine the presence of p53 immunoreactivity (IR), MDM2 IR, cell proliferation as evidenced by MIB1/Ki-67 IR and DNA fragmentation by in situ terminal transferase-mediated dUTP 3' end labelling (TUNEL), as a marker for apoptosis. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description In this study, we examined the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR. ### Output: The gene entity is HOTAIR.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description In this study, we examined the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR. ### Output: The disease is Metastatic malignant neoplasm to brain.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity HOTAIR and disease Metastatic malignant neoplasm to brain. ### Input: description In this study, we examined the expression of HOTAIR in 77 NSCLCs, their corresponding normal lung tissues and 6 brain metastases by quantitative real-time RT-PCR. ### Output: No relation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the gene entity. ### Input: description These results suggest that the HLA-G 14-bp insertion/deletion polymorphism may not be associated with HCC susceptibility and liver cirrhosis development in the Korean population. ### Output: The gene entity is HLA-G.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the disease entity. ### Input: description These results suggest that the HLA-G 14-bp insertion/deletion polymorphism may not be associated with HCC susceptibility and liver cirrhosis development in the Korean population. ### Output: The disease is Liver Cirrhosis.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: only according to the description, identify the type of relation between gene entity HLA-G and disease Liver Cirrhosis. ### Input: description These results suggest that the HLA-G 14-bp insertion/deletion polymorphism may not be associated with HCC susceptibility and liver cirrhosis development in the Korean population. ### Output: No relation.