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EleutherAI 721

pes2o-3104116

New maps of development: new visions of maturity. Two modes of moral reasoning are distinguished in boys' and girls' discussions of moral dilemmas: one oriented to justice and rights, one to care and response. These different modes are associated with different forms of self-definition and reflect different images of relationships. The contrasting images of hierarchy and web derive from childhood experiences of inequality and interdependence which give rise to the ideals of justice and of care. The representation of these two lines of development and their interplay yields a new mapping of human growth.

pes2o

{"added":"2018-04-03T02:15:58.092Z","created":"1982-04-01T00:00:00.000Z","id":"32729521","metadata":{"abstract":"Two modes of moral reasoning are distinguished in boys' and girls' discussions of moral dilemmas: one oriented to justice and rights, one to care and response. These different modes are associated with different forms of self-definition and reflect different images of relationships. The contrasting images of hierarchy and web derive from childhood experiences of inequality and interdependence which give rise to the ideals of justice and of care. The representation of these two lines of development and their interplay yields a new mapping of human growth.","abstract_count":86,"abstract_language":"en","abstract_perplexity":-12.558812316754167,"extfieldsofstudy":["Sociology","Medicine"],"provenance":"pes2o_v2-0000.json.gz:3104117","s2fieldsofstudy":["Psychology"],"sha1":"fe7b0c930f335e8368e3f3da0eb9f6eb1e24c926","sources":["Medline","MAG","Unpaywall"],"title":"New maps of development: new visions of maturity.","title_count":8,"title_language":"en","title_perplexity":-14.605785515126088,"top_frequencies":[{"count":13,"token":"of"},{"count":8,"token":"and"},{"count":3,"token":"to"},{"count":3,"token":"different"},{"count":2,"token":"new"},{"count":2,"token":"modes"},{"count":2,"token":"moral"},{"count":2,"token":"are"},{"count":2,"token":"one"},{"count":2,"token":"justice"},{"count":2,"token":"images"},{"count":2,"token":"The"},{"count":1,"token":"New"},{"count":1,"token":"maps"},{"count":1,"token":"development:"},{"count":1,"token":"visions"},{"count":1,"token":"maturity."},{"count":1,"token":"Two"},{"count":1,"token":"reasoning"},{"count":1,"token":"distinguished"},{"count":1,"token":"in"},{"count":1,"token":"boys'"},{"count":1,"token":"girls'"},{"count":1,"token":"discussions"},{"count":1,"token":"dilemmas:"},{"count":1,"token":"oriented"},{"count":1,"token":"rights,"},{"count":1,"token":"care"},{"count":1,"token":"response."},{"count":1,"token":"These"},{"count":1,"token":"associated"},{"count":1,"token":"with"},{"count":1,"token":"forms"},{"count":1,"token":"self-definition"},{"count":1,"token":"reflect"},{"count":1,"token":"relationships."},{"count":1,"token":"contrasting"},{"count":1,"token":"hierarchy"},{"count":1,"token":"web"},{"count":1,"token":"derive"},{"count":1,"token":"from"},{"count":1,"token":"childhood"},{"count":1,"token":"experiences"},{"count":1,"token":"inequality"},{"count":1,"token":"interdependence"},{"count":1,"token":"which"},{"count":1,"token":"give"},{"count":1,"token":"rise"},{"count":1,"token":"the"},{"count":1,"token":"ideals"},{"count":1,"token":"care."},{"count":1,"token":"representation"},{"count":1,"token":"these"},{"count":1,"token":"two"},{"count":1,"token":"lines"},{"count":1,"token":"development"},{"count":1,"token":"their"},{"count":1,"token":"interplay"},{"count":1,"token":"yields"},{"count":1,"token":"a"},{"count":1,"token":"mapping"},{"count":1,"token":"human"},{"count":1,"token":"growth."}],"year":1982},"source":"s2","version":"v3-fos"}

dclm-428943317

8 Surprising Uses For Sheds Daimler's "Illegal Mint" Little did Gottlieb Daimler know that while he was toiling the hours in an extension to his greenhouse working on the world's first lightweight four-stroke internal combustion engine that Karl and Berthe Benz were doing the same in their shed. Daimler and fellow inventor Wilhelm Maybach widened the garden path that led to the makeshift workshop at the bottom of the garden so that vehicles could be wheeled down to it. Their work was carried out in such secrecy in this remote garden building (servants were not allowed inside) that he was reported to the police for installing an illegal mint. Today, you might need one of those to afford a Maybach.

dclm

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pes2o-27493322

Trampling the sacred: multicultural education as pedagogical racism The following paper is a critical examination involving the misuse of sacred cultural tools and practices in the name of multicultural education. Native American practices are identified to illustrate how such inappropriate usages promote pedagogical racism. The misuse continues the hegemonic distribution of social capital. Through the irresponsible portrayal of complex and sophisticated cultures, American education continues to perpetuate pedagogical violence against children who are already socially and educationally disenfranchised. Using Freire, Giroux, Deloria, and Grande, this paper will identify strategies of communication and education necessary to eliminate pedagogical racism and begin to reverse the violence against children.

pes2o

{"added":"2019-05-06T14:08:33.569Z","created":"2012-10-15T00:00:00.000Z","id":"145112508","metadata":{"abstract":"The following paper is a critical examination involving the misuse of sacred cultural tools and practices in the name of multicultural education. Native American practices are identified to illustrate how such inappropriate usages promote pedagogical racism. The misuse continues the hegemonic distribution of social capital. Through the irresponsible portrayal of complex and sophisticated cultures, American education continues to perpetuate pedagogical violence against children who are already socially and educationally disenfranchised. Using Freire, Giroux, Deloria, and Grande, this paper will identify strategies of communication and education necessary to eliminate pedagogical racism and begin to reverse the violence against children.","abstract_count":98,"abstract_language":"en","abstract_perplexity":-13.82326843421274,"extfieldsofstudy":["Sociology"],"provenance":"pes2o_v2-0007.json.gz:386726","s2fieldsofstudy":["Education"],"sha1":"13c3fa052f20e70062bb516e61bc6761a293b06b","sources":["MergedPDFExtraction","TaylorAndFrancis","MAG","Unpaywall"],"title":"Trampling the sacred: multicultural education as pedagogical racism","title_count":8,"title_language":"en","title_perplexity":-15.882341022745788,"top_frequencies":[{"count":6,"token":"the"},{"count":6,"token":"and"},{"count":5,"token":"of"},{"count":4,"token":"pedagogical"},{"count":4,"token":"to"},{"count":3,"token":"education"},{"count":2,"token":"multicultural"},{"count":2,"token":"racism"},{"count":2,"token":"The"},{"count":2,"token":"paper"},{"count":2,"token":"misuse"},{"count":2,"token":"practices"},{"count":2,"token":"American"},{"count":2,"token":"are"},{"count":2,"token":"continues"},{"count":2,"token":"violence"},{"count":2,"token":"against"},{"count":1,"token":"Trampling"},{"count":1,"token":"sacred:"},{"count":1,"token":"as"},{"count":1,"token":"following"},{"count":1,"token":"is"},{"count":1,"token":"a"},{"count":1,"token":"critical"},{"count":1,"token":"examination"},{"count":1,"token":"involving"},{"count":1,"token":"sacred"},{"count":1,"token":"cultural"},{"count":1,"token":"tools"},{"count":1,"token":"in"},{"count":1,"token":"name"},{"count":1,"token":"education."},{"count":1,"token":"Native"},{"count":1,"token":"identified"},{"count":1,"token":"illustrate"},{"count":1,"token":"how"},{"count":1,"token":"such"},{"count":1,"token":"inappropriate"},{"count":1,"token":"usages"},{"count":1,"token":"promote"},{"count":1,"token":"racism."},{"count":1,"token":"hegemonic"},{"count":1,"token":"distribution"},{"count":1,"token":"social"},{"count":1,"token":"capital."},{"count":1,"token":"Through"},{"count":1,"token":"irresponsible"},{"count":1,"token":"portrayal"},{"count":1,"token":"complex"},{"count":1,"token":"sophisticated"},{"count":1,"token":"cultures,"},{"count":1,"token":"perpetuate"},{"count":1,"token":"children"},{"count":1,"token":"who"},{"count":1,"token":"already"},{"count":1,"token":"socially"},{"count":1,"token":"educationally"},{"count":1,"token":"disenfranchised."},{"count":1,"token":"Using"},{"count":1,"token":"Freire,"},{"count":1,"token":"Giroux,"},{"count":1,"token":"Deloria,"},{"count":1,"token":"Grande,"},{"count":1,"token":"this"},{"count":1,"token":"will"},{"count":1,"token":"identify"},{"count":1,"token":"strategies"},{"count":1,"token":"communication"},{"count":1,"token":"necessary"},{"count":1,"token":"eliminate"},{"count":1,"token":"begin"},{"count":1,"token":"reverse"},{"count":1,"token":"children."}],"year":2012},"source":"s2","version":"v3-fos"}

pes2o-7210752

Effect of Polyphenol Oxidase(PPO) Enzymatic Inducing Factors on Non-enzymatic Browning of Apple Polyphenols In order to study the effects of apple polyphenol oxidase(PPO) enzymatic inducing factors on the non-enzymatic browning of apple polyphenols, chlorogenic acid and phlorizin were used as reaction substrates, and phosphate buffer was used as the model apple juice system to carry out enzymatic induction under controlled enzymatic induction conditions. Subsequently, the enzyme was deactivated, and the non-enzymatic polymerization in the model apple juice system was carried out at 60 ℃; L*, a*, b*, and △E* values were measured using a colorimeter every 24 h. The results showed that significant differences were found in the impacts of enzymatic inducing factors on the non-enzymatic browning involving chlorogenic acid and phlorizin. In the 3.5~6.0 p H range, the degree of browning in the model juice system containing chlorogenic acid and phlorizin increased with increasing p H values. When the temperature of enzymatic induction was between 20 and 60 ℃, the temperature of the inducing system had no significant effect on the non-enzymatic browning involving chlorogenic acid, while the degree of non-enzymatic browning in the model juice using phlorizin was higher at 40 ℃. A higher degree of non-enzymatic browning was achieved for the model juice using chlorogenic acid and phlorizin when the durations of enzymatic induction were 40 and 30 min, respectively. When the PPO activity was in the range of 14.25~171 U, the increasing enzymatic activity could accelerate the non-enzymatic browning involving chlorogenic acid and phlorizin. Meanwhile, the results indicated that non-enzymatic browning involving phlorizin was related to the haze occurring in apple juice, and the development of the haze in apple juice could be accelerated by increasing the p H, temperature, PPO activities, and duration of enzymatic induction.

pes2o

{"added":"2019-03-31T13:48:06.937Z","created":"2015-01-01T00:00:00.000Z","id":"88257632","metadata":{"abstract":"In order to study the effects of apple polyphenol oxidase(PPO) enzymatic inducing factors on the non-enzymatic browning of apple polyphenols, chlorogenic acid and phlorizin were used as reaction substrates, and phosphate buffer was used as the model apple juice system to carry out enzymatic induction under controlled enzymatic induction conditions. Subsequently, the enzyme was deactivated, and the non-enzymatic polymerization in the model apple juice system was carried out at 60 \u2103; L*, a*, b*, and \u25b3E* values were measured using a colorimeter every 24 h. The results showed that significant differences were found in the impacts of enzymatic inducing factors on the non-enzymatic browning involving chlorogenic acid and phlorizin. In the 3.5~6.0 p H range, the degree of browning in the model juice system containing chlorogenic acid and phlorizin increased with increasing p H values. When the temperature of enzymatic induction was between 20 and 60 \u2103, the temperature of the inducing system had no significant effect on the non-enzymatic browning involving chlorogenic acid, while the degree of non-enzymatic browning in the model juice using phlorizin was higher at 40 \u2103. A higher degree of non-enzymatic browning was achieved for the model juice using chlorogenic acid and phlorizin when the durations of enzymatic induction were 40 and 30 min, respectively. When the PPO activity was in the range of 14.25~171 U, the increasing enzymatic activity could accelerate the non-enzymatic browning involving chlorogenic acid and phlorizin. Meanwhile, the results indicated that non-enzymatic browning involving phlorizin was related to the haze occurring in apple juice, and the development of the haze in apple juice could be accelerated by increasing the p H, temperature, PPO activities, and duration of enzymatic induction.","abstract_count":278,"abstract_language":"en","abstract_perplexity":-15.399023362733145,"extfieldsofstudy":["Chemistry"],"provenance":"pes2o_v2-0001.json.gz:3348221","s2fieldsofstudy":["Agricultural And Food Sciences"],"sha1":"34965dbb65c555b00decc4eac9519617445b377f","sources":["MAG"],"title":"Effect of Polyphenol Oxidase(PPO) Enzymatic Inducing Factors on Non-enzymatic Browning of Apple Polyphenols","title_count":13,"title_language":"en","title_perplexity":-17.751306675764898,"top_frequencies":[{"count":28,"token":"the"},{"count":14,"token":"of"},{"count":12,"token":"and"},{"count":8,"token":"enzymatic"},{"count":8,"token":"non-enzymatic"},{"count":8,"token":"browning"},{"count":8,"token":"was"},{"count":7,"token":"in"},{"count":6,"token":"apple"},{"count":6,"token":"chlorogenic"},{"count":6,"token":"juice"},{"count":5,"token":"acid"},{"count":5,"token":"phlorizin"},{"count":5,"token":"model"},{"count":4,"token":"on"},{"count":4,"token":"were"},{"count":4,"token":"system"},{"count":4,"token":"induction"},{"count":4,"token":"involving"},{"count":3,"token":"to"},{"count":3,"token":"inducing"},{"count":3,"token":"using"},{"count":3,"token":"p"},{"count":3,"token":"degree"},{"count":3,"token":"increasing"},{"count":2,"token":"In"},{"count":2,"token":"factors"},{"count":2,"token":"used"},{"count":2,"token":"as"},{"count":2,"token":"out"},{"count":2,"token":"at"},{"count":2,"token":"60"},{"count":2,"token":"results"},{"count":2,"token":"that"},{"count":2,"token":"significant"},{"count":2,"token":"phlorizin."},{"count":2,"token":"H"},{"count":2,"token":"When"},{"count":2,"token":"temperature"},{"count":2,"token":"higher"},{"count":2,"token":"40"},{"count":2,"token":"PPO"},{"count":2,"token":"activity"},{"count":2,"token":"could"},{"count":2,"token":"haze"},{"count":1,"token":"Effect"},{"count":1,"token":"Polyphenol"},{"count":1,"token":"Oxidase(PPO)"},{"count":1,"token":"Enzymatic"},{"count":1,"token":"Inducing"},{"count":1,"token":"Factors"},{"count":1,"token":"Non-enzymatic"},{"count":1,"token":"Browning"},{"count":1,"token":"Apple"},{"count":1,"token":"Polyphenols"},{"count":1,"token":"order"},{"count":1,"token":"study"},{"count":1,"token":"effects"},{"count":1,"token":"polyphenol"},{"count":1,"token":"oxidase(PPO)"},{"count":1,"token":"polyphenols,"},{"count":1,"token":"reaction"},{"count":1,"token":"substrates,"},{"count":1,"token":"phosphate"},{"count":1,"token":"buffer"},{"count":1,"token":"carry"},{"count":1,"token":"under"},{"count":1,"token":"controlled"},{"count":1,"token":"conditions."},{"count":1,"token":"Subsequently,"},{"count":1,"token":"enzyme"},{"count":1,"token":"deactivated,"},{"count":1,"token":"polymerization"},{"count":1,"token":"carried"},{"count":1,"token":"\u2103;"},{"count":1,"token":"L*,"},{"count":1,"token":"a*,"},{"count":1,"token":"b*,"},{"count":1,"token":"\u25b3E*"},{"count":1,"token":"values"},{"count":1,"token":"measured"},{"count":1,"token":"a"},{"count":1,"token":"colorimeter"},{"count":1,"token":"every"},{"count":1,"token":"24"},{"count":1,"token":"h."},{"count":1,"token":"The"},{"count":1,"token":"showed"},{"count":1,"token":"differences"},{"count":1,"token":"found"},{"count":1,"token":"impacts"},{"count":1,"token":"3.5~6.0"},{"count":1,"token":"range,"},{"count":1,"token":"containing"},{"count":1,"token":"increased"},{"count":1,"token":"with"},{"count":1,"token":"values."},{"count":1,"token":"between"},{"count":1,"token":"20"},{"count":1,"token":"\u2103,"}],"year":2015},"source":"s2","version":"v3-fos"}

flan-9107048

question: the u.n. agency for palestinian refugees said friday that it has halted all aid shipments into the gaza strip due to interference by the ruling hamas militant group . Write a brief summary in a sentence or so. summary: un halts aid to gaza cites hamas disruption question: with two acquisitions already this year , rbc centura might be on the prowl for more . Write a brief summary in a sentence or so. summary: analysts want more from rbc centura question: the nba 's instant replay system was an instant success this season . Write a brief summary in a sentence or so. summary: nba will go to instant replay again question: the french lower house narrowly approved draft legislation on wednesday that would further loosen rules -- cherished by many traditionalists -- that restrict commercial activity on sundays . Write a brief summary in a sentence or so. summary: french bill advances to open shops on sunday

flan

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flan-8066869

How is "Recital C of the resolution rightly points the finger at the economic considerations which led to the year being displayed as two digits only." said in German? In der Entschließung wird zu Recht in Erwägung C auf die wirtschaftlichen Beweggründe hingewiesen, die zur Kürzung der Jahreszahl auf zwei Ziffern geführt haben. How is "Subject: Security in Cyprus Given that the EU, and some Member States in particular, had raised objections to the initial plan of the Cyprus Government to site a surface-to-air missile system, consisting of S-300 missiles, on the island and subsequently congratulated it on its decision to cancel the plan, how does the Commission feel that Cyprus should improve its security?" said in German? Betrifft: Sicherheit auf Zypern Die EU - und einige Mitgliedstaaten im besonderen - hatten Bedenken erhoben gegen den ursprünglichen Plan der Regierung Zyperns, ein System für Boden-Luft-Flugkörper, bestehend aus 300 Flugkörpern, auf der Insel zu stationieren, und haben Zypern anschließend zu seinem Beschluß gratuliert, doch wieder von diesem Vorhaben Abstand zu nehmen. Wie sollte Zypern nun nach Auffassung der Kommission seine Sicherheit verbessern? How is "I am not in favour of nominalism." said in German? Ich bin nicht für Nominalismus. How is "is an Amsterdam-born historian, who took part in most highlights of the Sixties as a student leader." said in German? Nachher, entwickelte er das erste holländische Stadtviertelerneuerungsprogramm aus Sicht der Immigration von Gastarbeitern und ihren Familien und führte dessen Umsetzung in den achzigern Jahren in 16 Städten und 32 Vierteln im Auftage der niederländischen Regierung. Die holländische Erfahrungen wurden von ihm in den neunzigern Jahren beigetragen an den 'urban' Programmen der EU Kommission.

flan

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pes2o-21589652

Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(S)-amino-2-pyrrolidinone as a central template is described. After identifying compound 4, improvements in in vitro potency involved modifications of the liphophilic group and optimizing the angle of presentation of the amidine group to the S1 pocket of FXa. These studies ultimately led to compound RPR120844, a potent inhibitor of FXa (K(i) = 7 nM) which shows selectivity for FXa over trypsin, thrombin, and several fibrinolytic serine proteinases. RPR120844 is an effective anticoagulant in both the rat model of FeCl(2)-induced carotid artery thrombosis and the rabbit model of jugular vein thrombus formation.

pes2o

{"added":"2018-04-03T00:48:17.934Z","created":"1999-08-21T00:00:00.000Z","id":"24796057","metadata":{"abstract":"The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(S)-amino-2-pyrrolidinone as a central template is described. After identifying compound 4, improvements in in vitro potency involved modifications of the liphophilic group and optimizing the angle of presentation of the amidine group to the S1 pocket of FXa. These studies ultimately led to compound RPR120844, a potent inhibitor of FXa (K(i) = 7 nM) which shows selectivity for FXa over trypsin, thrombin, and several fibrinolytic serine proteinases. RPR120844 is an effective anticoagulant in both the rat model of FeCl(2)-induced carotid artery thrombosis and the rabbit model of jugular vein thrombus formation.","abstract_count":103,"abstract_language":"en","abstract_perplexity":-17.273441993135894,"extfieldsofstudy":["Chemistry","Medicine"],"provenance":"pes2o_v2-0005.json.gz:2226917","s2fieldsofstudy":["Biology","Chemistry"],"sha1":"e857e467e51f0b2d3e9dea30b913ca2693b2d964","sources":["Unpaywall","Medline","MAG"],"title":"Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa.","title_count":14,"title_language":"en","title_perplexity":-14.68946210474865,"top_frequencies":[{"count":11,"token":"of"},{"count":6,"token":"the"},{"count":5,"token":"and"},{"count":3,"token":"a"},{"count":3,"token":"in"},{"count":2,"token":"potent"},{"count":2,"token":"inhibitors"},{"count":2,"token":"factor"},{"count":2,"token":"is"},{"count":2,"token":"compound"},{"count":2,"token":"group"},{"count":2,"token":"to"},{"count":2,"token":"FXa"},{"count":2,"token":"model"},{"count":1,"token":"Design"},{"count":1,"token":"structure-activity"},{"count":1,"token":"relationships"},{"count":1,"token":"selective"},{"count":1,"token":"blood"},{"count":1,"token":"coagulation"},{"count":1,"token":"Xa."},{"count":1,"token":"The"},{"count":1,"token":"discovery"},{"count":1,"token":"series"},{"count":1,"token":"non-peptide"},{"count":1,"token":"Xa"},{"count":1,"token":"(FXa)"},{"count":1,"token":"incorporating"},{"count":1,"token":"3-(S)-amino-2-pyrrolidinone"},{"count":1,"token":"as"},{"count":1,"token":"central"},{"count":1,"token":"template"},{"count":1,"token":"described."},{"count":1,"token":"After"},{"count":1,"token":"identifying"},{"count":1,"token":"4,"},{"count":1,"token":"improvements"},{"count":1,"token":"vitro"},{"count":1,"token":"potency"},{"count":1,"token":"involved"},{"count":1,"token":"modifications"},{"count":1,"token":"liphophilic"},{"count":1,"token":"optimizing"},{"count":1,"token":"angle"},{"count":1,"token":"presentation"},{"count":1,"token":"amidine"},{"count":1,"token":"S1"},{"count":1,"token":"pocket"},{"count":1,"token":"FXa."},{"count":1,"token":"These"},{"count":1,"token":"studies"},{"count":1,"token":"ultimately"},{"count":1,"token":"led"},{"count":1,"token":"RPR120844,"},{"count":1,"token":"inhibitor"},{"count":1,"token":"(K(i)"},{"count":1,"token":"="},{"count":1,"token":"7"},{"count":1,"token":"nM)"},{"count":1,"token":"which"},{"count":1,"token":"shows"},{"count":1,"token":"selectivity"},{"count":1,"token":"for"},{"count":1,"token":"over"},{"count":1,"token":"trypsin,"},{"count":1,"token":"thrombin,"},{"count":1,"token":"several"},{"count":1,"token":"fibrinolytic"},{"count":1,"token":"serine"},{"count":1,"token":"proteinases."},{"count":1,"token":"RPR120844"},{"count":1,"token":"an"},{"count":1,"token":"effective"},{"count":1,"token":"anticoagulant"},{"count":1,"token":"both"},{"count":1,"token":"rat"},{"count":1,"token":"FeCl(2)-induced"},{"count":1,"token":"carotid"},{"count":1,"token":"artery"},{"count":1,"token":"thrombosis"},{"count":1,"token":"rabbit"},{"count":1,"token":"jugular"},{"count":1,"token":"vein"},{"count":1,"token":"thrombus"},{"count":1,"token":"formation."}],"year":1999},"source":"s2","version":"v3-fos"}

pes2o-10923173

The 3s2 3p5 → 3s3p5 (3P)np series in Cl I The photoabsorption spectrum of neutral chlorine has been photographed for the first time in the wavelength region 400-700 Å, the absorbing atomic vapour being produced by means of the flash-pyrolysis technique. Nine autoionizing resonances have been observed and identified as forming a series arising from the excitation of the inner 3s electron. The agreement with theoretical results is discussed.

pes2o

{"added":"2022-07-22T06:40:39.893Z","created":"1991-01-01T00:00:00.000Z","id":"250872013","metadata":{"abstract":"The photoabsorption spectrum of neutral chlorine has been photographed for the first time in the wavelength region 400-700 \u00c5, the absorbing atomic vapour being produced by means of the flash-pyrolysis technique. Nine autoionizing resonances have been observed and identified as forming a series arising from the excitation of the inner 3s electron. The agreement with theoretical results is discussed.","abstract_count":59,"abstract_language":"en","abstract_perplexity":-14.637748124324244,"extfieldsofstudy":["Physics"],"provenance":"pes2o_v2-0002.json.gz:3183972","s2fieldsofstudy":["Physics"],"sha1":"44c2983ab1f66ce41e268c2945f9b99ffae69baa","sources":["ScienceParsePlus","IOP","MergedPDFExtraction"],"title":"The 3s2 3p5 \u2192 3s3p5 (3P)np series in Cl I","title_count":10,"title_language":"en","title_perplexity":-20.858869410267555,"top_frequencies":[{"count":6,"token":"the"},{"count":3,"token":"The"},{"count":3,"token":"of"},{"count":2,"token":"series"},{"count":2,"token":"in"},{"count":2,"token":"been"},{"count":1,"token":"3s2"},{"count":1,"token":"3p5"},{"count":1,"token":"\u2192"},{"count":1,"token":"3s3p5"},{"count":1,"token":"(3P)np"},{"count":1,"token":"Cl"},{"count":1,"token":"I"},{"count":1,"token":"photoabsorption"},{"count":1,"token":"spectrum"},{"count":1,"token":"neutral"},{"count":1,"token":"chlorine"},{"count":1,"token":"has"},{"count":1,"token":"photographed"},{"count":1,"token":"for"},{"count":1,"token":"first"},{"count":1,"token":"time"},{"count":1,"token":"wavelength"},{"count":1,"token":"region"},{"count":1,"token":"400-700"},{"count":1,"token":"\u00c5,"},{"count":1,"token":"absorbing"},{"count":1,"token":"atomic"},{"count":1,"token":"vapour"},{"count":1,"token":"being"},{"count":1,"token":"produced"},{"count":1,"token":"by"},{"count":1,"token":"means"},{"count":1,"token":"flash-pyrolysis"},{"count":1,"token":"technique."},{"count":1,"token":"Nine"},{"count":1,"token":"autoionizing"},{"count":1,"token":"resonances"},{"count":1,"token":"have"},{"count":1,"token":"observed"},{"count":1,"token":"and"},{"count":1,"token":"identified"},{"count":1,"token":"as"},{"count":1,"token":"forming"},{"count":1,"token":"a"},{"count":1,"token":"arising"},{"count":1,"token":"from"},{"count":1,"token":"excitation"},{"count":1,"token":"inner"},{"count":1,"token":"3s"},{"count":1,"token":"electron."},{"count":1,"token":"agreement"},{"count":1,"token":"with"},{"count":1,"token":"theoretical"},{"count":1,"token":"results"},{"count":1,"token":"is"},{"count":1,"token":"discussed."}],"year":1991},"source":"s2","version":"v3-fos"}

pes2o-2838005

NF-κB signaling is increased in HD3 cells following exposure to 1,4-benzoquinone: role of reactive oxygen species and p38-MAPK. In utero exposure to benzene, a known environmental contaminant, is associated with increased risk of leukemia. We have previously shown that in utero benzene exposure can alter the redox-sensitive transcription factor NF-κB, and we hypothesize that this is through benzene-induced reactive oxygen species (ROS) production interfering with the signaling pathway involving NF-κB and p38-Mitogen Activated Protein Kinase (MAPK). As benzoquinone (BQ) is one of benzene's most toxic metabolites, the objectives of this study were to determine whether ROS and p38-MAPK-mediated BQ-induced increased NF-κB activity. HD3 chicken erythroblast cells were transfected with an NF-κB luciferase-linked reporter plasmid and exposed to BQ (25 μM) for 2-24 h. NF-κB activities were determined through luciferase assays; Western blotting was conducted to assess changes in protein levels in nontransfected cells; and the presence of ROS was determined via 2',7'-dichlorodihydrofluorescein diacetate (DCFDA) flow cytometric assays. Results demonstrated that NF-κB activity was significantly increased following exposure to BQ for 16 and 24 h and DCFDA assays and pretreatment with antioxidants indicated that BQ-mediated ROS production was responsible for this increase. Furthermore, decreased inhibitor of kappaB-alpha (IκB-α) expression suggests that nuclear factor-kappaB (NF-κB) translocates into the nucleus and that p38-MAPK activation through a ROS-dependent pathway mediates BQ-mediated increases in NF-κB activity. Future studies investigating the role of p38-MAPK in this pathway are warranted. Evaluating the effects of toxicant exposure on cell signaling pathways is vital for understanding mechanisms of xenobiotic-induced toxicity.

pes2o

{"added":"2018-04-03T04:28:46.992Z","created":"2014-02-01T00:00:00.000Z","id":"39078690","metadata":{"abstract":"In utero exposure to benzene, a known environmental contaminant, is associated with increased risk of leukemia. We have previously shown that in utero benzene exposure can alter the redox-sensitive transcription factor NF-\u03baB, and we hypothesize that this is through benzene-induced reactive oxygen species (ROS) production interfering with the signaling pathway involving NF-\u03baB and p38-Mitogen Activated Protein Kinase (MAPK). As benzoquinone (BQ) is one of benzene's most toxic metabolites, the objectives of this study were to determine whether ROS and p38-MAPK-mediated BQ-induced increased NF-\u03baB activity. HD3 chicken erythroblast cells were transfected with an NF-\u03baB luciferase-linked reporter plasmid and exposed to BQ (25 \u03bcM) for 2-24 h. NF-\u03baB activities were determined through luciferase assays; Western blotting was conducted to assess changes in protein levels in nontransfected cells; and the presence of ROS was determined via 2',7'-dichlorodihydrofluorescein diacetate (DCFDA) flow cytometric assays. Results demonstrated that NF-\u03baB activity was significantly increased following exposure to BQ for 16 and 24 h and DCFDA assays and pretreatment with antioxidants indicated that BQ-mediated ROS production was responsible for this increase. Furthermore, decreased inhibitor of kappaB-alpha (I\u03baB-\u03b1) expression suggests that nuclear factor-kappaB (NF-\u03baB) translocates into the nucleus and that p38-MAPK activation through a ROS-dependent pathway mediates BQ-mediated increases in NF-\u03baB activity. Future studies investigating the role of p38-MAPK in this pathway are warranted. Evaluating the effects of toxicant exposure on cell signaling pathways is vital for understanding mechanisms of xenobiotic-induced toxicity.","abstract_count":233,"abstract_language":"en","abstract_perplexity":-17.725082047785335,"extfieldsofstudy":["Medicine","Biology"],"provenance":"pes2o_v2-0000.json.gz:2838006","s2fieldsofstudy":["Biology"],"sha1":"11a532bf4baddaad22ed7301deee3aee6efaa944","sources":["ScienceParsePlus","Medline","Adhoc","MergedPDFExtraction","Unpaywall","MAG"],"title":"NF-\u03baB signaling is increased in HD3 cells following exposure to 1,4-benzoquinone: role of reactive oxygen species and p38-MAPK.","title_count":18,"title_language":"en","title_perplexity":-19.690850403055975,"top_frequencies":[{"count":10,"token":"and"},{"count":9,"token":"of"},{"count":7,"token":"NF-\u03baB"},{"count":7,"token":"the"},{"count":6,"token":"in"},{"count":6,"token":"to"},{"count":6,"token":"that"},{"count":5,"token":"is"},{"count":5,"token":"exposure"},{"count":4,"token":"increased"},{"count":4,"token":"with"},{"count":4,"token":"this"},{"count":4,"token":"for"},{"count":4,"token":"was"},{"count":3,"token":"signaling"},{"count":3,"token":"through"},{"count":3,"token":"pathway"},{"count":3,"token":"were"},{"count":3,"token":"ROS"},{"count":2,"token":"HD3"},{"count":2,"token":"cells"},{"count":2,"token":"following"},{"count":2,"token":"role"},{"count":2,"token":"reactive"},{"count":2,"token":"oxygen"},{"count":2,"token":"species"},{"count":2,"token":"utero"},{"count":2,"token":"a"},{"count":2,"token":"production"},{"count":2,"token":"activity."},{"count":2,"token":"BQ"},{"count":2,"token":"determined"},{"count":2,"token":"BQ-mediated"},{"count":2,"token":"p38-MAPK"},{"count":1,"token":"1,4-benzoquinone:"},{"count":1,"token":"p38-MAPK."},{"count":1,"token":"In"},{"count":1,"token":"benzene,"},{"count":1,"token":"known"},{"count":1,"token":"environmental"},{"count":1,"token":"contaminant,"},{"count":1,"token":"associated"},{"count":1,"token":"risk"},{"count":1,"token":"leukemia."},{"count":1,"token":"We"},{"count":1,"token":"have"},{"count":1,"token":"previously"},{"count":1,"token":"shown"},{"count":1,"token":"benzene"},{"count":1,"token":"can"},{"count":1,"token":"alter"},{"count":1,"token":"redox-sensitive"},{"count":1,"token":"transcription"},{"count":1,"token":"factor"},{"count":1,"token":"NF-\u03baB,"},{"count":1,"token":"we"},{"count":1,"token":"hypothesize"},{"count":1,"token":"benzene-induced"},{"count":1,"token":"(ROS)"},{"count":1,"token":"interfering"},{"count":1,"token":"involving"},{"count":1,"token":"p38-Mitogen"},{"count":1,"token":"Activated"},{"count":1,"token":"Protein"},{"count":1,"token":"Kinase"},{"count":1,"token":"(MAPK)."},{"count":1,"token":"As"},{"count":1,"token":"benzoquinone"},{"count":1,"token":"(BQ)"},{"count":1,"token":"one"},{"count":1,"token":"benzene's"},{"count":1,"token":"most"},{"count":1,"token":"toxic"},{"count":1,"token":"metabolites,"},{"count":1,"token":"objectives"},{"count":1,"token":"study"},{"count":1,"token":"determine"},{"count":1,"token":"whether"},{"count":1,"token":"p38-MAPK-mediated"},{"count":1,"token":"BQ-induced"},{"count":1,"token":"chicken"},{"count":1,"token":"erythroblast"},{"count":1,"token":"transfected"},{"count":1,"token":"an"},{"count":1,"token":"luciferase-linked"},{"count":1,"token":"reporter"},{"count":1,"token":"plasmid"},{"count":1,"token":"exposed"},{"count":1,"token":"(25"},{"count":1,"token":"\u03bcM)"},{"count":1,"token":"2-24"},{"count":1,"token":"h."},{"count":1,"token":"activities"},{"count":1,"token":"luciferase"},{"count":1,"token":"assays;"},{"count":1,"token":"Western"},{"count":1,"token":"blotting"},{"count":1,"token":"conducted"},{"count":1,"token":"assess"},{"count":1,"token":"changes"}],"year":2014},"source":"s2","version":"v3-fos"}

wikipedia-5048603

New Slaves "New Slaves" is a song by American hip hop recording artist Kanye West, from his sixth studio album "Yeezus" (2013). It was produced primarily by West, with additional production by Ben Bronfman, Mike Dean, Travis Scott, Noah Goldstein, Sham Joseph, and Che Pope. The song's lyrics discuss slavery and segregation, as well as racism in general, materialism, and stereotypes of African Americans in the United States. It features vocals from American recording artist Frank Ocean, whom West previously collaborated with on "Watch the Throne" (2011). The song's coda features a sample of "Gyöngyhajú lány" by Hungarian composer Gábor Presser, who later sued West in 2016 over its use. Before its release on the album, West promoted it extensively, projecting it on over 60 locations around the world, and performing it live on "Saturday Night Live" and at the "Later... With Jools Holland". Since release, the song has received widespread acclaim from music critics, with many praising its message, sample, and Ocean's appearance. Despite not being released as a single, the song charted in Canada, France, the United Kingdom, and the United States in 2013. It was nominated for Best Rap Song at the 56th Annual Grammy Awards and appeared on several year-end lists. West later performed the song on The Yeezus Tour. Background. In a 2014 interview with Zach Baron of "GQ", West claimed to have engaged in numerous meetings that included what he dubbed as "Stay in your place" type conversations. They were described as what lead him "to the point of creating 'New Slaves' and 'Blood on the Leaves' and the entire "Yeezus" album, and to make the album basically like a protest in music." The track samples "HBA War" by Dutch E Germ; "Yeezus" production consultant Arca introduced West to the track. The conclusion of "New Slaves" features Ocean singing over a sample of "Gyöngyhajú lány" (1969) by Hungarian rock band Omega. In 2016, Hungarian composer Gábor Presser, who wrote "Gyöngyhajú lány" in 1969, claimed that West asked him for permission to use that composition as the outro of "New Slaves", and gave him a $10,000 check as a deposit toward a future agreement. The check was not cashed, and Presser filed a lawsuit against West, seeking $2.5 million. After unsuccessful negotiations between Presser and West through 2016, Judge Lewis A. Kaplan of the US Southern District of New York rejected the rapper's attempt to dismiss the suit and to transfer the case out in December. Just two days before West was slated to be deposed in the case, he reached an out-of-court deal with Presser on March 20, 2017. Details of the deal are not disclosed. Release and promotion. "New Slaves" was released on June 18, 2013, as the fourth track on West's sixth studio album "Yeezus". Prior to the song's release, it was played at 66 locations whilst a black-and-white video of West performing it was projected on various buildings in various countries around the world, including at Wrigley Field and the Royal Ontario Museum. Miriam Coleman said the simplicity of the video "provided a striking context for the rapper's searing lyrics on race and materialism". Two projections in Texas (including the Rothko Chapel) were dismissed by police prior to commencing due to a lack of permit. Another projection at Miami Beach, Florida was shut down by police, but left fans excited and eager to see the song's then-upcoming performance on "Saturday Night Live". West performed "New Slaves", along with "Black Skinhead", on "Saturday Night Live" on May 18, 2013. During the performance, West stood in place and stared dead-eyed at the camera the whole time, performing "in front of a projection of eyes." West also changed his lyrics to more TV-friendly, changing words such as "dick" to "prick." West subsequently performed the song live at the Governors Ball Music Festival on June 9, 2013. During the performance, West "paused and breathed audibly between scant verses, allowing interludes of emptiness to add to the corrosive aura." Critical reception. "New Slaves" has received widespread acclaim from music critics, with its message, sample, and Ocean's appearance receiving praise. Farber of the "Daily News" said the song has a "heavy metal girth that still swings" and called the sampling of "Gyöngyhajú lány" by Omega "the most cool, and obscure, sample" on "Yeezus". Robert Christgau of "MSN Music" cited "New Slaves", along with "Hold My Liquor", as the album's highlights. Michael Madden of "Consequence of Sound" writes: "'New Slaves' has one of the clearer concepts on the whole album, about the relationship West sees between blacks of different classes and consumerism," calling upon the lyrics: "You see it's broke-nigga racism, that's that Don't touch anything in the store'/ And this rich-nigga racism, that's that Come in, please buy more." Madden ultimately called "New Slaves" one of the album's "essential tracks," along with "Black Skinhead", "Blood on the Leaves", and "Bound 2". Evan Rytlewski of "The A.V. Club" called the song "menacing" and praised its coda with Frank Ocean. West himself has voiced his love for the song, tweeting that the second verse is the best rap verse of all time in July 2013, and reiterating his opinion in a 2014 interview with "GQ" magazine. Accolades. On June 26, 2013, "Time" named "New Slaves" the "Best Song of 2013 (So Far)" and later on December 20, 2013, placed it first on its "The 25 Best Songs of 2013 (The Entire Year)." On December 2, 2013, "Complex" named "New Slaves" the best song of 2013. Dave Bry commented saying, "Plenty of artists sold more records than Kanye West in 2013. No one did anything near to as artistically powerful. "New Slaves" is the best song of the year. And it's not even close." "NME" ranked the song at number 36 on their list of the 50 best songs of 2013. It was named the second best song of 2013 by "Pitchfork". They elaborated saying, ""New Slaves" is the hardened cartilage of Yeezus, the leanest and grisliest piece of music on an album without a single yielding surface. There isn't a wasted breath or unnecessary word; every single thought cleaves through the meat. [...] Yes, Kanye is a wealthy man, and yes, the particulars of his rage might be convoluted, involving his lack of access to the upper reaches of the fashion industry. But its source comes from an acute, unwavering awareness of a central fact: Even in the elite corridors of power where he now walks, some doors are still locked. On "New Slaves", he transforms into the hordes demanding entry. To paraphrase the words of his one-time mentor: The whole industry could hate him; he'll flail his way through." The song earned a Grammy nomination for Best Rap Song at the 56th Annual Grammy Awards, ultimately losing to "Thrift Shop" by Macklemore &amp; Ryan Lewis featuring Wanz. Live performances. Before its release on the album, West performed "New Slaves", along with "Black Skinhead", on "Saturday Night Live" on May 18, 2013. The performance introduced audiences to West's new creative shift for "Yeezus" and showed how musically different the album would be from his previous, "My Beautiful Dark Twisted Fantasy" (2010). West performed the song again at the Governors Ball Music Festival on June 9, 2013, nine days before the release of the album. Following the release of "Yeezus", West performed the song live at the first concert of The Yeezus Tour at the Barclays Center in New York City. West wore a jeweled mask during the show, which Jim Farber of New York Daily News believed contributed to "the industrial fusion he has injected on "Yeezus"." When commenting on his performance of "New Slaves" and "Black Skinhead", Farber writes: "West delivers [them] with the brutality they deserve." In September 2013, West performed an acoustic rendition of the song with Charlie Wilson on "Later... with Jools Holland". Credits and personnel. Credits adapted from the "Yeezus" liner notes.

wikipedia

{"added":"2023-04-02T20:40:41.324Z","created":"2023-04-02T20:40:41.324Z","id":"39417623","metadata":{"length":1695,"provenance":"en_simple_wiki_v0-0001.json.gz:1828402","revid":"1129221455","url":"https:\/\/en.wikipedia.org\/wiki?curid=39417623"},"source":"wikipedia","version":"v0"}

flan-13213741

Question: Based on the sentence "Wet brown dog, jumping out of the water.", is the sentence "The dog is wet from jumping in the water." true? OPTIONS: - yes - it is not possible to tell - no Answer: yes Is the premise "A woman in black holds her mouth walking down the street with a young boy." true if "The woman is walking down the street with a young girl."? OPTIONS: - yes - it is not possible to tell - no no Q: "The band is practicing before the championship game." Does this mean that "The solo band is practicing before the championship game."? OPTIONS: - yes - it is not possible to tell - no A: it is not possible to tell Premise & Hypothesis & Options: A man wearing a blue casual shirt with money green shorts and black hat pointing toward the yellow object in an elderly gathering. A man is trying to show others what a banana looks like OPTIONS: - yes - it is not possible to tell - no Is the hypothesis true or not: it is not possible to tell Premise & hypothesis: Is the premise "A woman is laying on the beach next to her bike." true if "A woman is laying on a towel."? OPTIONS: - yes - it is not possible to tell - no A: it is not possible to tell Premise & hypothesis: Is the premise "Two men in belt harnesses are working on a construction project, though only one wears his hard hat." true if "One man is acting in an unsafe manner"? OPTIONS: - yes - it is not possible to tell - no A: it is not possible to tell

flan

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dclm-429596050

h a l f b a k e r y It's not a thing. It will be a thing. account: browse anonymously, or get an account and write. ]~[ Rotary Engine (+2, -2)   [vote for, I thought of this engine after seeing the Radmax TM ROTARY ENGINE (see link). This idea is kind of hard to explain verbally, but I’ll try. There’s also a picture thingy I made that shows the combustion cycle. The basic idea of the engine is two cams facing towards each other with a combustion space and a rotor in between them, and a mechanical output shaft through the center. The rotor can slide along the shaft, but it only rotates with the shaft. The rotor divides the combustion space into four separate sections (two on each side). There are two full combustion cycles of the engine per revolution. The engine could be made to have multiple combustion chambers and rotors, or the rotor and chamber could be made with a larger diameter to have twice as many combustion cycles (four), which would make it have a slower rotation speed but more power and torque output. One problem I can think of is vibration of the engine; the vibration can be reduced by making the engine flatter. BJS, Feb 16 2007 Radmax TM ROTARY ENGINE http://www.regtech....otaryprinciple.html [BJS, Feb 16 2007] Rotary Engine Concept picture thingy http://www.putfile....pic.php?img=4782119 Imagine this image around a cylinder. [BJS, Feb 16 2007]        So this is just a bigger version of the Radmax engine or what? discontinuuity, Feb 16 2007        No, it's not bigger version of the Radmax engine. BJS, Feb 16 2007        interesting, but is it an improvement?           the rotor bobbing up and down while also rotating seems to add complexity (and vibration as you mention) without benefits. xaviergisz, Feb 16 2007        I don't know if it would be an improvement, it's just an idea.           Sealing it might also be a problem. BJS, Feb 16 2007        I don't see how compression could be formed. Explanation? nomel, Feb 16 2007        "I don't see how compression could be formed. Explanation?" Did you see the picture? BJS, Feb 16 2007        I had no trouble with the link to the picture. It's clever, but yeah, how are you going to seal it. baconbrain, Feb 16 2007        I saw the picture but it appears that when it rotates, the seal will be lost between "chambers"/section. You have "compression" marked, but, from what I can see, if anything moved from where it is, the seal would be lost. What forms the seal? Just contact between the metal? If this is the case, where will lubrication take place?           I'm just having trouble seeing the concept. Maybe you could animate it? nomel, Feb 17 2007        I don't know how to seal it...           I could make an animation of it, but I have other things I'm supposed to be doing right now. BJS, Feb 17 2007        hrmmm...well if you don't have a seal, then it's not going to make any power. fishy for you. nomel, Feb 18 2007        This sounds an awful lot like the Rand Cam Klaatu, Feb 18 2007        Looking at the Rotary Engine Concept picture thingy, I think this engine is brilliant. It's like a rotary version of the Scuderi engine but without any valves.           My feeling is that there might be a way to wrap that image around a circle the other way, turning it into a toothed gear. Eliminate either the top or bottom half of the mechanism, and you end up with a toothed gear rotating within a toothed stator; the stator has intake/exhaust holes as well as the transfer gaps.           By rotating it around a circle, the wobbling motion is turned into natural circular motion, and manufacturing becomes infinitely simpler. IJK, Mar 24 2007 back: main index

dclm

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pes2o-19171226

Merging and Outsourcing Information Systems with UML Businesses can change their business structure by merging with other companies or, on the other end of the spectrum, by smoothly outsourcing some of their business processes to other more specialized parties. In this paper, we will concentrate on conceptual modelling of merging and outsourcing information systems. Merging of a collection of information systems will be defined as the construction of a global information system that contains exactly the functionality of the original collection of systems. Such global information systems are called federated information systems, when we wish to address the situation where the component systems are so-called legacy systems; that is, systems that are given beforehand and that are to interoperate in an integrated single framework in which the legacy systems are to maintain as much as possible their respective autonomy. Two major problems in constructing federated information systems concern achieving and maintaining consistency, and a uniform representation of the data on the global level of the federation. The process of creation of uniform representations of data is known as data extraction, whereas data reconciliation is concerned with resolving data inconsistencies. Outsourcing of an information system, on the other hand, will be defined as the handing over of part of the functionality of the original system to an outside party (the supplier). Such functionality typically involves one or more operations, where each operation satisfies certain input and output requirements. These requirements will be defined in terms of the ruling service level agreements (SLAs). We will provide a formal means to ensure that the outsourcing relationship between outsourcing party and supplier, determined by an SLA, satisfies specific correctness criteria. Formal specifications, as offered in this paper, can prove their value in the setup and evaluation of outsourcing contracts. We shall describe a uniform semantic framework for specification of both federated and outsourced information systems based on the UML/OCL data model. In particular, we will show that we can represent so-called exact views in UML/OCL, providing

pes2o

{"added":"2016-01-07T01:57:53.067Z","created":"2006-01-01T00:00:00.000Z","id":"1650516","metadata":{"abstract":"Businesses can change their business structure by merging with other companies or, on the other end of the spectrum, by smoothly outsourcing some of their business processes to other more specialized parties. In this paper, we will concentrate on conceptual modelling of merging and outsourcing information systems. Merging of a collection of information systems will be defined as the construction of a global information system that contains exactly the functionality of the original collection of systems. Such global information systems are called federated information systems, when we wish to address the situation where the component systems are so-called legacy systems; that is, systems that are given beforehand and that are to interoperate in an integrated single framework in which the legacy systems are to maintain as much as possible their respective autonomy. Two major problems in constructing federated information systems concern achieving and maintaining consistency, and a uniform representation of the data on the global level of the federation. The process of creation of uniform representations of data is known as data extraction, whereas data reconciliation is concerned with resolving data inconsistencies. Outsourcing of an information system, on the other hand, will be defined as the handing over of part of the functionality of the original system to an outside party (the supplier). Such functionality typically involves one or more operations, where each operation satisfies certain input and output requirements. These requirements will be defined in terms of the ruling service level agreements (SLAs). We will provide a formal means to ensure that the outsourcing relationship between outsourcing party and supplier, determined by an SLA, satisfies specific correctness criteria. Formal specifications, as offered in this paper, can prove their value in the setup and evaluation of outsourcing contracts. We shall describe a uniform semantic framework for specification of both federated and outsourced information systems based on the UML\/OCL data model. In particular, we will show that we can represent so-called exact views in UML\/OCL, providing","abstract_count":325,"abstract_language":"en","abstract_perplexity":-12.66603274846659,"extfieldsofstudy":["Business"],"provenance":"pes2o_v2-0004.json.gz:3684619","s2fieldsofstudy":["Computer Science"],"sha1":"c5e90978ad0130cdaf85500268a96dfbd2ae7a66","sources":["Unpaywall","Grobid","ScienceParseMerged","Crawler","MAG"],"title":"Merging and Outsourcing Information Systems with UML","title_count":7,"title_language":"en","title_perplexity":-12.131033010983458,"top_frequencies":[{"count":20,"token":"of"},{"count":19,"token":"the"},{"count":9,"token":"and"},{"count":8,"token":"information"},{"count":7,"token":"systems"},{"count":7,"token":"in"},{"count":6,"token":"to"},{"count":6,"token":"will"},{"count":6,"token":"as"},{"count":6,"token":"that"},{"count":6,"token":"data"},{"count":5,"token":"on"},{"count":5,"token":"outsourcing"},{"count":5,"token":"a"},{"count":5,"token":"are"},{"count":4,"token":"their"},{"count":4,"token":"other"},{"count":4,"token":"we"},{"count":4,"token":"an"},{"count":3,"token":"with"},{"count":3,"token":"can"},{"count":3,"token":"by"},{"count":3,"token":"be"},{"count":3,"token":"defined"},{"count":3,"token":"global"},{"count":3,"token":"functionality"},{"count":3,"token":"federated"},{"count":3,"token":"uniform"},{"count":2,"token":"Merging"},{"count":2,"token":"Outsourcing"},{"count":2,"token":"business"},{"count":2,"token":"merging"},{"count":2,"token":"more"},{"count":2,"token":"In"},{"count":2,"token":"this"},{"count":2,"token":"paper,"},{"count":2,"token":"systems."},{"count":2,"token":"collection"},{"count":2,"token":"system"},{"count":2,"token":"original"},{"count":2,"token":"Such"},{"count":2,"token":"where"},{"count":2,"token":"so-called"},{"count":2,"token":"legacy"},{"count":2,"token":"framework"},{"count":2,"token":"level"},{"count":2,"token":"is"},{"count":2,"token":"party"},{"count":2,"token":"satisfies"},{"count":2,"token":"We"},{"count":1,"token":"Information"},{"count":1,"token":"Systems"},{"count":1,"token":"UML"},{"count":1,"token":"Businesses"},{"count":1,"token":"change"},{"count":1,"token":"structure"},{"count":1,"token":"companies"},{"count":1,"token":"or,"},{"count":1,"token":"end"},{"count":1,"token":"spectrum,"},{"count":1,"token":"smoothly"},{"count":1,"token":"some"},{"count":1,"token":"processes"},{"count":1,"token":"specialized"},{"count":1,"token":"parties."},{"count":1,"token":"concentrate"},{"count":1,"token":"conceptual"},{"count":1,"token":"modelling"},{"count":1,"token":"construction"},{"count":1,"token":"contains"},{"count":1,"token":"exactly"},{"count":1,"token":"called"},{"count":1,"token":"systems,"},{"count":1,"token":"when"},{"count":1,"token":"wish"},{"count":1,"token":"address"},{"count":1,"token":"situation"},{"count":1,"token":"component"},{"count":1,"token":"systems;"},{"count":1,"token":"is,"},{"count":1,"token":"given"},{"count":1,"token":"beforehand"},{"count":1,"token":"interoperate"},{"count":1,"token":"integrated"},{"count":1,"token":"single"},{"count":1,"token":"which"},{"count":1,"token":"maintain"},{"count":1,"token":"much"},{"count":1,"token":"possible"},{"count":1,"token":"respective"},{"count":1,"token":"autonomy."},{"count":1,"token":"Two"},{"count":1,"token":"major"},{"count":1,"token":"problems"},{"count":1,"token":"constructing"},{"count":1,"token":"concern"},{"count":1,"token":"achieving"},{"count":1,"token":"maintaining"},{"count":1,"token":"consistency,"},{"count":1,"token":"representation"}],"year":2006},"source":"s2","version":"v3-fos"}

pes2o-23246949

Valuing Japan-based German expatriate and local manager's functions: do subsidiary age and managerial perspectives matter? Managerial functions valued by expatriates and reasons for appointing host country managers were examined in an exploratory, multimethod (interview and questionnaire) study with expatriates and local managers as the respondents. Based on theoretical perspectives of agency theory, transaction costs theory, resource-based views and organizational learning theory, changes in the valuation of these functions were hypothesized and examined for subsidiary age and nationality of the respondent. Expatriate and local managers' views supported previous research on certain management functions but differed on others (e.g. management development). The data indicated curvilinear relationships for a number of managerial functions between nationality of top manager and age of the subsidiary. Strategic factors were analysed by subsidiary age and nationality of the respondent manager to understand more about maturity of host company operations and strategic orientations. The results indicated the growth in the strategic functions of technological leadership and market development/branding in older subsidiaries. Implications of the results were discussed.

pes2o

{"added":"2019-05-16T13:04:12.356Z","created":"2011-02-01T00:00:00.000Z","id":"154492137","metadata":{"abstract":"Managerial functions valued by expatriates and reasons for appointing host country managers were examined in an exploratory, multimethod (interview and questionnaire) study with expatriates and local managers as the respondents. Based on theoretical perspectives of agency theory, transaction costs theory, resource-based views and organizational learning theory, changes in the valuation of these functions were hypothesized and examined for subsidiary age and nationality of the respondent. Expatriate and local managers' views supported previous research on certain management functions but differed on others (e.g. management development). The data indicated curvilinear relationships for a number of managerial functions between nationality of top manager and age of the subsidiary. Strategic factors were analysed by subsidiary age and nationality of the respondent manager to understand more about maturity of host company operations and strategic orientations. The results indicated the growth in the strategic functions of technological leadership and market development\/branding in older subsidiaries. Implications of the results were discussed.","abstract_count":154,"abstract_language":"en","abstract_perplexity":-13.531312361492164,"extfieldsofstudy":["Business"],"provenance":"pes2o_v2-0006.json.gz:32141","s2fieldsofstudy":["Business"],"sha1":"3c0036f5647c99105a0b01cfe575ae4e45dbb854","sources":["Unpaywall","TaylorAndFrancis","MAG"],"title":"Valuing Japan-based German expatriate and local manager's functions: do subsidiary age and managerial perspectives matter?","title_count":15,"title_language":"en","title_perplexity":-16.44977378469846,"top_frequencies":[{"count":13,"token":"and"},{"count":10,"token":"of"},{"count":8,"token":"the"},{"count":5,"token":"functions"},{"count":4,"token":"age"},{"count":4,"token":"were"},{"count":4,"token":"in"},{"count":3,"token":"local"},{"count":3,"token":"subsidiary"},{"count":3,"token":"for"},{"count":3,"token":"on"},{"count":3,"token":"theory,"},{"count":3,"token":"nationality"},{"count":2,"token":"managerial"},{"count":2,"token":"perspectives"},{"count":2,"token":"by"},{"count":2,"token":"expatriates"},{"count":2,"token":"host"},{"count":2,"token":"managers"},{"count":2,"token":"examined"},{"count":2,"token":"views"},{"count":2,"token":"management"},{"count":2,"token":"The"},{"count":2,"token":"indicated"},{"count":2,"token":"manager"},{"count":2,"token":"strategic"},{"count":2,"token":"results"},{"count":1,"token":"Valuing"},{"count":1,"token":"Japan-based"},{"count":1,"token":"German"},{"count":1,"token":"expatriate"},{"count":1,"token":"manager's"},{"count":1,"token":"functions:"},{"count":1,"token":"do"},{"count":1,"token":"matter?"},{"count":1,"token":"Managerial"},{"count":1,"token":"valued"},{"count":1,"token":"reasons"},{"count":1,"token":"appointing"},{"count":1,"token":"country"},{"count":1,"token":"an"},{"count":1,"token":"exploratory,"},{"count":1,"token":"multimethod"},{"count":1,"token":"(interview"},{"count":1,"token":"questionnaire)"},{"count":1,"token":"study"},{"count":1,"token":"with"},{"count":1,"token":"as"},{"count":1,"token":"respondents."},{"count":1,"token":"Based"},{"count":1,"token":"theoretical"},{"count":1,"token":"agency"},{"count":1,"token":"transaction"},{"count":1,"token":"costs"},{"count":1,"token":"resource-based"},{"count":1,"token":"organizational"},{"count":1,"token":"learning"},{"count":1,"token":"changes"},{"count":1,"token":"valuation"},{"count":1,"token":"these"},{"count":1,"token":"hypothesized"},{"count":1,"token":"respondent."},{"count":1,"token":"Expatriate"},{"count":1,"token":"managers'"},{"count":1,"token":"supported"},{"count":1,"token":"previous"},{"count":1,"token":"research"},{"count":1,"token":"certain"},{"count":1,"token":"but"},{"count":1,"token":"differed"},{"count":1,"token":"others"},{"count":1,"token":"(e.g."},{"count":1,"token":"development)."},{"count":1,"token":"data"},{"count":1,"token":"curvilinear"},{"count":1,"token":"relationships"},{"count":1,"token":"a"},{"count":1,"token":"number"},{"count":1,"token":"between"},{"count":1,"token":"top"},{"count":1,"token":"subsidiary."},{"count":1,"token":"Strategic"},{"count":1,"token":"factors"},{"count":1,"token":"analysed"},{"count":1,"token":"respondent"},{"count":1,"token":"to"},{"count":1,"token":"understand"},{"count":1,"token":"more"},{"count":1,"token":"about"},{"count":1,"token":"maturity"},{"count":1,"token":"company"},{"count":1,"token":"operations"},{"count":1,"token":"orientations."},{"count":1,"token":"growth"},{"count":1,"token":"technological"},{"count":1,"token":"leadership"},{"count":1,"token":"market"},{"count":1,"token":"development\/branding"},{"count":1,"token":"older"},{"count":1,"token":"subsidiaries."}],"year":2011},"source":"s2","version":"v3-fos"}

dclm-428104914

Burger King® 15971 US RT 33 Nelsonville, OH 45764 (740) 753-4374 About Burger King® There's a BURGER KING® restaurant near you at 15971 US RT 33. Visit us or call for more information. Every day, more than 11 million guests visit over 13,000 BURGER KING® restaurants near them in 97 countries around the world. And they do so because our fast food restaurants are known for serving high-quality, great-tasting and affordable food. The BURGER KING® restaurant in Nelsonville, OH serves burgers, breakfast, lunch and dinner prepared your way. The original HOME OF THE WHOPPER®, our commitment to quality ingredients, signature recipes, iconic sandwiches like the flame-grilled WHOPPER® Sandwich and fast, family-friendly dining experiences in a welcoming environment is what has defined our brand for more than 50 successful years. Nearby Locations

dclm

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flan-9859389

question: COMING INTO FORCE: --> French. answer: ENTRÉE EN VIGUEUR : question: Any decision as to the termination of vendor's contract or any subcontractor shall be made by the buyer, at the sole discretion of the buyer. --> French. answer: Toute décision de résilier le contrat du fournisseur ou d’un sous-traitant sera prise par l’acheteur, à son entière discrétion. question: The then applicants furthermore considered it established that there had been a misuse of powers and an infringement of Article 39 of the EC Treaty (now Article 33 EC). --> French. answer: Les requérantes considéraient en outre comme établis les vices de détournement de pouvoir et de violation de l'article 39 du traité CE (devenu article 33 CE). question: Although, as I point out in my report, it would, technically speaking, be perfectly possible to continue to accept new Member States, even if the Treaty of Lisbon were not to enter into force, doing so requires political will, and it is this that it is my job and that of my fellow Members here in Parliament to create. --> French. answer: Bien que, comme je le souligne dans mon rapport, il serait, d'un point de vue technique, tout à fait possible d'accepter de nouveaux États membres, même si le traité de Lisbonne devait ne pas entrer en vigueur, il faut pour cela une volonté politique, et c'est mon travail, ainsi que celui de mes camarades députés, réunis ici au Parlement, de créer cette volonté.

flan

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flan-12664378

IN: French: The amending formula was also the subject of study by a special joint committee of the Senate and the House of Commons in 1991. OUT: La formule de modification a également été examinée en 1991 par un comité mixte spécial du Sénat et de la Chambre des communes. IN: French: Labour legislation defines a range of leaves (maternity, paternity, adoption, parental and others), which are subsidized by the public social security system in order to promote the sharing of responsibilities and the reconciling of work and family life. OUT: La législation du travail comporte toute une série de congés (maternité, paternité, adoption, parental ou autres) subventionnés par le système de sécurité sociale publique afin de promouvoir le partage des responsabilités et la conciliation de la vie professionnelle et familiale. IN: French: b) Relations between the EU and Croatia Amid increasing tension within the Socialist Federal Republic of Yugoslavia, Croatia declared independence on 25 June 1991. This was suspended for three months and confirmed on 8 October 1991 (by Parliament’s decision on the abrogation of the state-legal ties with the former SFRY). OUT: sources d’information, notamment des États membres, des organisations internationales (Conseil de l'Europe, OSCE, HCR, TPIY, Pacte de stabilité, FMI, Banque mondiale, BERD, BEI etc.) et des ONG. b) Relations entre l'Union européenne et la Croatie Dans un climat de tension croissante au sein de la république fédérative socialiste de Yougoslavie, la Croatie a déclaré son indépendance le 25 juin 1991. IN: French: In a case in which the Inter-American Commission on Human Rights found a violation of articles 25 and 8 of ACHR (the rights to effective judicial protection and to a fair trial, respectively) because the petitioner had been denied access to contentious administrative proceedings to challenge his dismissal, it recommended that the State party permit the petitioner “access to contentious administrative proceedings, in order that he might appeal the legality of the administrative act that mandated his dismissal”. OUT: Dans un cas où elle a conclu à la violation des articles 8 et 25 de la Convention américaine relative aux droits de l'homme (les droits à une protection judiciaire effective et à un jugement équitable, respectivement) parce que le requérant n'avait pas eu la possibilité d'introduire un recours administratif pour contester son licenciement, la Commission interaméricaine des droits de l'homme a recommandé à l'État partie d'autoriser le requérant « à introduire un recours administratif pour contester la légalité de l'acte administratif signifiant son licenciement ».

flan

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flan-8578419

Question: What is the solution? Solve -25*f = -67*f - 82*f - 13*f + 4521 for f. Answer: 33 Question: What is the solution? Solve 202*b + 386 - 4199 = -581 for b. Answer: 16 Question: What is the solution? Solve 439 - 4057 = 208*y + 3*y + 391 for y. Answer: -19 Question: What is the solution? Solve 0 = -3*x + 11 - 5 for x. Answer: 2

flan

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flan-25032022

How is "In Kuwait, work in the diplomatic and consular corps is restricted to men alone, with the one exception of the woman at the head of the Kuwaiti diplomatic mission in Vienna, who was formerly a member of the Permanent Mission of Kuwait in New York, following which she was appointed as Kuwait's ambassador to South Africa." said in French? La nomination dans les corps diplomatique et consulaire koweïtiens est limitée aux hommes, à l'exception notable de la chef de la mission diplomatique du Koweït à Vienne, qui était auparavant membre de la Mission permanente du Koweït à New York puis a été nommée ambassadrice du Koweït en Afrique du Sud.

flan

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dclm-411648434

The Global Vegan Cosmetics Market is expected to grow from USD 13,100.38 Million in 2019 to USD 19,373.16 Million by the end of 2025 at a Compound Annual Growth Rate (CAGR) of 6.73%. Market Segmentation & Coverage: This research report categorizes the Vegan Cosmetics to forecast the revenues and analyze the trends in each of the following sub-markets: Based on Product, the Vegan Cosmetics Market studied across Hair Care, Makeup, and Skin Care. Based on Distribution Channel, the Vegan Cosmetics Market studied across Departmental Stores, E-commerce, Hypermarket/Supermarket, and Specialty Stores. Company Usability Profiles: The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Vegan Cosmetics Market including Bare Blossom Skincare & Organics, Billy Jealousy, Debenhams Plc, e.l.f. Beauty Inc., Ecco Bella, L’Or?al SA, Lush Fresh Handmade Cosmetics, Modern Minerals Makeup, MuLondon Natural Skincare, and Urban Decay. FPNV Positioning Matrix: The FPNV Positioning Matrix evaluates and categorizes the vendors in the Vegan Cosmetics Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape. Competitive Strategic Window: Cumulative Impact of COVID-19: The report provides insights on the following pointers: The report answers questions such as: 1. What is the market size and forecast of the Global Vegan Cosmetics Market? 2. What are the inhibiting factors and impact of COVID-19 shaping the Global Vegan Cosmetics Market during the forecast period? 3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Vegan Cosmetics Market? 4. What is the competitive strategic window for opportunities in the Global Vegan Cosmetics Market? 5. What are the technology trends and regulatory frameworks in the Global Vegan Cosmetics Market? 6. What are the modes and strategic moves considered suitable for entering the Global Vegan Cosmetics Market?

dclm

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dclm-417700635

Desperate Housewives Season 1 "One Wonderful Day" Bree and Rex make amends, but then tragedy hits the Van De Kamp family. Zach learns what happened to his father. Edie meets the new residents of Wisteria Lane. "Goodbye For Now" Susan and Mike move in together. Lynette tries to make sure Annabel (Melinda McGraw) doesn't come between her and Tom, but ends up getting Tom fired. "Sunday in the Park with George" George continues to weasel his way into Bree's Life. Rex's health continues to detoriate. Lynette tries to spice things up with Tom. "Fear No More" Gabrielle plans a farewell party for Carlos before he leaves for jail for eight months. George Williams (Roger Bart) resurfaces in Bree's life. "Live Alone and Like It" Lynette learns that no good deed goes unpunished when she befriends Mrs. McCluskey. Susan's mother tries to jump start her and her daughter's love lives and ends up picking him up a man. "Children Will Listen" "There Won't Be Trumpets" "The Ladies Who Lunch" Mike is questioned about Mrs. Huber's murder by the police and is temporarily arrested. John's friend, Justin (Ryan Carnes) attempts to blackmail Gabrielle into making him her new gardener. "Love is in the Air" When Lynette's father-in-aw, Rodney Scavo (Ryan O'Neal), comes to visit, she learns that he's been cheating on his wife. Susan is disturbed by Julie's romance with Zach. "Every Day a Little Death" The residents of Wisteria Lane learn that Martha Huber has passed away and they discover she kept a journal, forcing Susan to confess to Edie about her role in burning the house down. Edie organizes a neighborhood search for the missing Mrs. Huber, just as her sister, Felicia Tilman (Harriet Sansom Harris) arrives. Bree asks an attractive pharmacist on a date. "Come Back to Me" Maisy Gibbons (Sharon Lawrence) returns and her secret life intersects with Bree's. Gabrielle gets a taste of her own medicine when Carlos confesses in jail. Susan plans to take her relationship with Mike to the next level. "Suspicious Minds" Gabrielle organizes a Halston fashion show for charity highlighting the ladies of Wisteria Lane. John's mother, Helen Rowlan (Kathryn Harrold) thinks her son is sleeping with Susan and not Gabrielle, but Gabrielle soon confesses. The aftermath of Bree's son Andrew running over Carlos' mother. Susan grows suspicious of Mike's intentions of moving to Wisteria Lane. Lynette reaches the breaking point in her addiction to ADD medication. "Anything You Can Do" Susan and Mike's first official date is postponed when a sexy house guest, Kendra (Heather Stephens), comes to visit Mike. Lynette becomes more dependent on her kids' ADD medication. "Running to Stand Still" Lynette butts heads with Maisy Gibbons (Sharon Lawrence) at the twins' school over a play. Susan investigates the mystery of Zach's sudden disappearance. "Come In, Stranger" A break-in on Wisteria Lane makes a vulnerable Susan accept a date with a policeman when Mike seems indifferent. Rex takes the kids for the weekend, leaving a lonely Bree behind. "Who's That Woman?" Cash-strapped Mrs. Huber blackmails Susan about being involved with Edie's housefire. Carlos becomes suspicious that Gabrielle is having an affair and accuses the wrong man. "Pretty Little Picture" The ladies host the big dinner party that the late Mary Alice Young had planned; Gabrielle finds herself being blackmailed by a nine-year-old who catches her with ther gardener "Ah, But Underneath" Edie crashes Mike's dinner date with Susan; Gabrielle realizes her gardener is taking their fling too seriously; Bree forces Rex to go to therapy; Lynette resorts to drastic measures to keep her kids in line. Mary Alice Young commits suicide one day in her house. She narrates the story of her family, friends and neighbors from her point of view. Desperate Housewives Air Dates: Total Episodes: Desperate Housewives Season 1 Quotes Mary Alice Lynette: Now listen to me, you are going to behave. I will not be humiliated in front of the entire neighborhood. And just so you know that I'm serious, I am. (She pulls out paper) Porter: What's that? Lynette: Santa's cell phone number! Preston: How'd you get that? Lynette: I know someone who knows someone who knows an elf. And if any of you acts up, so help me I will call Santa and tell him you want socks for Christmas! All right, are you willing to risk that!?

dclm

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pes2o-24037526

Vein wrapping for chronic nerve constriction injury in a rat model: study showing increases in VEGF and HGF production and prevention of pain-associated behaviors and nerve damage. BACKGROUND Although efficacious clinical results have been reported after vein wrapping for the treatment of recurrent compressive neuropathy, the mechanism of nerve protection remains uncertain. METHODS Eight-week-old male Wistar rats (n = 90) were randomly divided into three groups: sham procedure, chronic constriction injury, and chronic constriction injury plus vein wrapping. Mechanical withdrawal thresholds and walking patterns were measured with use of von Frey filaments and the CatWalk system, respectively. We investigated L4-L5 dorsal root ganglia immunohistochemically at fourteen days postsurgery and sciatic nerves histologically at fourteen days and again five months postsurgery. Concentrations of several sciatic neurotrophic factors in the ligated sciatic nerves were quantified with use of ELISA (enzyme-linked immunosorbent assay). RESULTS In behavioral tests, the rats in which the chronic constriction injury had been followed by vein wrapping displayed significantly greater pain responses than the sham group, and the group with untreated chronic constriction injury showed greater pain responses than the vein-wrapping group (both p < 0.05). Immunoreactive markers of inflammation and nerve damage, calcitonin gene-related peptide (CGRP) and activating transcription factor-3 (ATF3), were upregulated in dorsal root ganglion neurons in the constriction-injury and vein-wrapping groups compared with those in the sham group, with greater upregulation in the constriction-injury group than in the vein-wrapping group (both p < 0.01). Histologic observation showed marked nerve degeneration and scar tissue formation around the sciatic nerve in the constriction-injury group, but these effects were prevented to some extent in the vein-wrapping group. Vascular endothelial growth factor (VEGF) levels at one and three days postsurgery and hepatocyte growth factor (HGF) levels at three, seven, fourteen, and twenty-eight days postsurgery were significantly higher in the vein-wrapping group than in the other groups (p < 0.05). CONCLUSIONS Vein wrapping decreased pain-associated behavior and nerve damage caused by chronic constriction injury. VEGF and HGF produced in response to vein grafts may play a mechanistic role. CLINICAL RELEVANCE These findings may lead to development of new therapies employing growth factors, with or without other materials, that simulate vein wrapping.

pes2o

{"added":"2018-04-03T01:20:59.490Z","created":"2014-05-21T00:00:00.000Z","id":"22958957","metadata":{"abstract":"BACKGROUND\nAlthough efficacious clinical results have been reported after vein wrapping for the treatment of recurrent compressive neuropathy, the mechanism of nerve protection remains uncertain.\n\n\nMETHODS\nEight-week-old male Wistar rats (n = 90) were randomly divided into three groups: sham procedure, chronic constriction injury, and chronic constriction injury plus vein wrapping. Mechanical withdrawal thresholds and walking patterns were measured with use of von Frey filaments and the CatWalk system, respectively. We investigated L4-L5 dorsal root ganglia immunohistochemically at fourteen days postsurgery and sciatic nerves histologically at fourteen days and again five months postsurgery. Concentrations of several sciatic neurotrophic factors in the ligated sciatic nerves were quantified with use of ELISA (enzyme-linked immunosorbent assay).\n\n\nRESULTS\nIn behavioral tests, the rats in which the chronic constriction injury had been followed by vein wrapping displayed significantly greater pain responses than the sham group, and the group with untreated chronic constriction injury showed greater pain responses than the vein-wrapping group (both p < 0.05). Immunoreactive markers of inflammation and nerve damage, calcitonin gene-related peptide (CGRP) and activating transcription factor-3 (ATF3), were upregulated in dorsal root ganglion neurons in the constriction-injury and vein-wrapping groups compared with those in the sham group, with greater upregulation in the constriction-injury group than in the vein-wrapping group (both p < 0.01). Histologic observation showed marked nerve degeneration and scar tissue formation around the sciatic nerve in the constriction-injury group, but these effects were prevented to some extent in the vein-wrapping group. Vascular endothelial growth factor (VEGF) levels at one and three days postsurgery and hepatocyte growth factor (HGF) levels at three, seven, fourteen, and twenty-eight days postsurgery were significantly higher in the vein-wrapping group than in the other groups (p < 0.05).\n\n\nCONCLUSIONS\nVein wrapping decreased pain-associated behavior and nerve damage caused by chronic constriction injury. VEGF and HGF produced in response to vein grafts may play a mechanistic role.\n\n\nCLINICAL RELEVANCE\nThese findings may lead to development of new therapies employing growth factors, with or without other materials, that simulate vein wrapping.","abstract_count":334,"abstract_language":"en","abstract_perplexity":-16.241104700295732,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0006.json.gz:822718","s2fieldsofstudy":["Biology","Medicine"],"sha1":"a0bc8e27f691ebe4af6c22cf127929e968220e45","sources":["MergedPDFExtraction","Medline","Unpaywall","MAG"],"title":"Vein wrapping for chronic nerve constriction injury in a rat model: study showing increases in VEGF and HGF production and prevention of pain-associated behaviors and nerve damage.","title_count":27,"title_language":"en","title_perplexity":-14.49384208516575,"top_frequencies":[{"count":18,"token":"and"},{"count":18,"token":"the"},{"count":14,"token":"in"},{"count":8,"token":"of"},{"count":7,"token":"nerve"},{"count":6,"token":"chronic"},{"count":6,"token":"constriction"},{"count":6,"token":"were"},{"count":6,"token":"with"},{"count":5,"token":"vein"},{"count":5,"token":"group"},{"count":5,"token":"vein-wrapping"},{"count":4,"token":"wrapping"},{"count":4,"token":"injury"},{"count":4,"token":"at"},{"count":4,"token":"days"},{"count":4,"token":"sciatic"},{"count":4,"token":"than"},{"count":3,"token":"sham"},{"count":3,"token":"postsurgery"},{"count":3,"token":"greater"},{"count":3,"token":"group,"},{"count":3,"token":"<"},{"count":3,"token":"constriction-injury"},{"count":3,"token":"to"},{"count":3,"token":"growth"},{"count":2,"token":"Vein"},{"count":2,"token":"for"},{"count":2,"token":"a"},{"count":2,"token":"VEGF"},{"count":2,"token":"HGF"},{"count":2,"token":"pain-associated"},{"count":2,"token":"been"},{"count":2,"token":"rats"},{"count":2,"token":"three"},{"count":2,"token":"wrapping."},{"count":2,"token":"use"},{"count":2,"token":"dorsal"},{"count":2,"token":"root"},{"count":2,"token":"fourteen"},{"count":2,"token":"nerves"},{"count":2,"token":"by"},{"count":2,"token":"significantly"},{"count":2,"token":"pain"},{"count":2,"token":"responses"},{"count":2,"token":"showed"},{"count":2,"token":"(both"},{"count":2,"token":"p"},{"count":2,"token":"0.05)."},{"count":2,"token":"groups"},{"count":2,"token":"factor"},{"count":2,"token":"levels"},{"count":2,"token":"other"},{"count":2,"token":"may"},{"count":1,"token":"rat"},{"count":1,"token":"model:"},{"count":1,"token":"study"},{"count":1,"token":"showing"},{"count":1,"token":"increases"},{"count":1,"token":"production"},{"count":1,"token":"prevention"},{"count":1,"token":"behaviors"},{"count":1,"token":"damage."},{"count":1,"token":"BACKGROUND"},{"count":1,"token":"Although"},{"count":1,"token":"efficacious"},{"count":1,"token":"clinical"},{"count":1,"token":"results"},{"count":1,"token":"have"},{"count":1,"token":"reported"},{"count":1,"token":"after"},{"count":1,"token":"treatment"},{"count":1,"token":"recurrent"},{"count":1,"token":"compressive"},{"count":1,"token":"neuropathy,"},{"count":1,"token":"mechanism"},{"count":1,"token":"protection"},{"count":1,"token":"remains"},{"count":1,"token":"uncertain."},{"count":1,"token":"METHODS"},{"count":1,"token":"Eight-week-old"},{"count":1,"token":"male"},{"count":1,"token":"Wistar"},{"count":1,"token":"(n"},{"count":1,"token":"="},{"count":1,"token":"90)"},{"count":1,"token":"randomly"},{"count":1,"token":"divided"},{"count":1,"token":"into"},{"count":1,"token":"groups:"},{"count":1,"token":"procedure,"},{"count":1,"token":"injury,"},{"count":1,"token":"plus"},{"count":1,"token":"Mechanical"},{"count":1,"token":"withdrawal"},{"count":1,"token":"thresholds"},{"count":1,"token":"walking"},{"count":1,"token":"patterns"},{"count":1,"token":"measured"},{"count":1,"token":"von"}],"year":2014},"source":"s2","version":"v3-fos"}

pes2o-15104363

Impact of Wind Power and Photovoltaic Cell Power on Power System Stability Based on L Index L index is proposed to assess the impact of wind power and photovoltaic cell power on system stability. L index is a voltage stability index which is based on power flow and can reflect the weak point where wind power and photovoltaic cell are connected to. Because the day trends of the two DGs are different, the impacts of stability are different. The example shows wind power system could cause voltage stability fluctuation. And the photovoltaic cell could enhance stability in strong light and high temperature in daytime.

pes2o

{"added":"2017-02-24T19:11:08.977Z","created":"2012-03-27T00:00:00.000Z","id":"44541064","metadata":{"abstract":"L index is proposed to assess the impact of wind power and photovoltaic cell power on system stability. L index is a voltage stability index which is based on power flow and can reflect the weak point where wind power and photovoltaic cell are connected to. Because the day trends of the two DGs are different, the impacts of stability are different. The example shows wind power system could cause voltage stability fluctuation. And the photovoltaic cell could enhance stability in strong light and high temperature in daytime.","abstract_count":88,"abstract_language":"en","abstract_perplexity":-12.140337017771705,"extfieldsofstudy":["Environmental Science"],"provenance":"pes2o_v2-0003.json.gz:3489173","s2fieldsofstudy":["Engineering","Environmental Science"],"sha1":"121fad97e3b26870d3710741fbb93c506448579a","sources":["ScienceParseMerged","MAG","Unpaywall","IEEE"],"title":"Impact of Wind Power and Photovoltaic Cell Power on Power System Stability Based on L Index","title_count":16,"title_language":"en","title_perplexity":-11.121987890026766,"top_frequencies":[{"count":6,"token":"the"},{"count":5,"token":"and"},{"count":5,"token":"power"},{"count":4,"token":"of"},{"count":4,"token":"on"},{"count":4,"token":"stability"},{"count":3,"token":"Power"},{"count":3,"token":"L"},{"count":3,"token":"index"},{"count":3,"token":"is"},{"count":3,"token":"wind"},{"count":3,"token":"photovoltaic"},{"count":3,"token":"cell"},{"count":3,"token":"are"},{"count":2,"token":"system"},{"count":2,"token":"voltage"},{"count":2,"token":"could"},{"count":2,"token":"in"},{"count":1,"token":"Impact"},{"count":1,"token":"Wind"},{"count":1,"token":"Photovoltaic"},{"count":1,"token":"Cell"},{"count":1,"token":"System"},{"count":1,"token":"Stability"},{"count":1,"token":"Based"},{"count":1,"token":"Index"},{"count":1,"token":"proposed"},{"count":1,"token":"to"},{"count":1,"token":"assess"},{"count":1,"token":"impact"},{"count":1,"token":"stability."},{"count":1,"token":"a"},{"count":1,"token":"which"},{"count":1,"token":"based"},{"count":1,"token":"flow"},{"count":1,"token":"can"},{"count":1,"token":"reflect"},{"count":1,"token":"weak"},{"count":1,"token":"point"},{"count":1,"token":"where"},{"count":1,"token":"connected"},{"count":1,"token":"to."},{"count":1,"token":"Because"},{"count":1,"token":"day"},{"count":1,"token":"trends"},{"count":1,"token":"two"},{"count":1,"token":"DGs"},{"count":1,"token":"different,"},{"count":1,"token":"impacts"},{"count":1,"token":"different."},{"count":1,"token":"The"},{"count":1,"token":"example"},{"count":1,"token":"shows"},{"count":1,"token":"cause"},{"count":1,"token":"fluctuation."},{"count":1,"token":"And"},{"count":1,"token":"enhance"},{"count":1,"token":"strong"},{"count":1,"token":"light"},{"count":1,"token":"high"},{"count":1,"token":"temperature"},{"count":1,"token":"daytime."}],"year":2012},"source":"s2","version":"v3-fos"}

pes2o-11019276

Technology extraction from time series data reflecting expert operator skills and knowledge Continuation processes in chemical and/or biotechnical plants always generate a large amount of time series data. However, since conventional process models are described as a set of control models, it is difficult to explain the complicated and active plant behaviours. Based on the background, this paper proposes a novel method to develop a process response model from continuous time-series data. The method consists of the following phases: (1) reciprocal correlation analysis, (2) process response model, (3) extraction of control rules, (4) extraction of a workflow and (5) detecting outliers. The main contribution of the research is to establish a method to mine a set of meaningful control rules from Learning Classifier System (LCS) using the Minimum Description Length (MDL) criteria and Tabu search method. The proposed method has been applied to an actual process of a biochemical plant and has shown the validity and the effectiveness.

pes2o

{"added":"2018-01-23T22:42:11.579Z","created":"2008-12-31T00:00:00.000Z","id":"41086273","metadata":{"abstract":"Continuation processes in chemical and\/or biotechnical plants always generate a large amount of time series data. However, since conventional process models are described as a set of control models, it is difficult to explain the complicated and active plant behaviours. Based on the background, this paper proposes a novel method to develop a process response model from continuous time-series data. The method consists of the following phases: (1) reciprocal correlation analysis, (2) process response model, (3) extraction of control rules, (4) extraction of a workflow and (5) detecting outliers. The main contribution of the research is to establish a method to mine a set of meaningful control rules from Learning Classifier System (LCS) using the Minimum Description Length (MDL) criteria and Tabu search method. The proposed method has been applied to an actual process of a biochemical plant and has shown the validity and the effectiveness.","abstract_count":146,"abstract_language":"en","abstract_perplexity":-14.622418492212738,"extfieldsofstudy":["Engineering","Computer Science"],"provenance":"pes2o_v2-0002.json.gz:3280075","s2fieldsofstudy":["Computer Science"],"sha1":"6c6cdc504704f56557d31bcb42592182736c82b0","sources":["DBLP","MAG","Unpaywall"],"title":"Technology extraction from time series data reflecting expert operator skills and knowledge","title_count":12,"title_language":"en","title_perplexity":-11.999942198241254,"top_frequencies":[{"count":8,"token":"a"},{"count":8,"token":"of"},{"count":7,"token":"the"},{"count":6,"token":"and"},{"count":5,"token":"to"},{"count":4,"token":"process"},{"count":4,"token":"method"},{"count":3,"token":"extraction"},{"count":3,"token":"from"},{"count":3,"token":"control"},{"count":3,"token":"The"},{"count":2,"token":"time"},{"count":2,"token":"series"},{"count":2,"token":"data."},{"count":2,"token":"set"},{"count":2,"token":"is"},{"count":2,"token":"plant"},{"count":2,"token":"response"},{"count":2,"token":"has"},{"count":1,"token":"Technology"},{"count":1,"token":"data"},{"count":1,"token":"reflecting"},{"count":1,"token":"expert"},{"count":1,"token":"operator"},{"count":1,"token":"skills"},{"count":1,"token":"knowledge"},{"count":1,"token":"Continuation"},{"count":1,"token":"processes"},{"count":1,"token":"in"},{"count":1,"token":"chemical"},{"count":1,"token":"and\/or"},{"count":1,"token":"biotechnical"},{"count":1,"token":"plants"},{"count":1,"token":"always"},{"count":1,"token":"generate"},{"count":1,"token":"large"},{"count":1,"token":"amount"},{"count":1,"token":"However,"},{"count":1,"token":"since"},{"count":1,"token":"conventional"},{"count":1,"token":"models"},{"count":1,"token":"are"},{"count":1,"token":"described"},{"count":1,"token":"as"},{"count":1,"token":"models,"},{"count":1,"token":"it"},{"count":1,"token":"difficult"},{"count":1,"token":"explain"},{"count":1,"token":"complicated"},{"count":1,"token":"active"},{"count":1,"token":"behaviours."},{"count":1,"token":"Based"},{"count":1,"token":"on"},{"count":1,"token":"background,"},{"count":1,"token":"this"},{"count":1,"token":"paper"},{"count":1,"token":"proposes"},{"count":1,"token":"novel"},{"count":1,"token":"develop"},{"count":1,"token":"model"},{"count":1,"token":"continuous"},{"count":1,"token":"time-series"},{"count":1,"token":"consists"},{"count":1,"token":"following"},{"count":1,"token":"phases:"},{"count":1,"token":"(1)"},{"count":1,"token":"reciprocal"},{"count":1,"token":"correlation"},{"count":1,"token":"analysis,"},{"count":1,"token":"(2)"},{"count":1,"token":"model,"},{"count":1,"token":"(3)"},{"count":1,"token":"rules,"},{"count":1,"token":"(4)"},{"count":1,"token":"workflow"},{"count":1,"token":"(5)"},{"count":1,"token":"detecting"},{"count":1,"token":"outliers."},{"count":1,"token":"main"},{"count":1,"token":"contribution"},{"count":1,"token":"research"},{"count":1,"token":"establish"},{"count":1,"token":"mine"},{"count":1,"token":"meaningful"},{"count":1,"token":"rules"},{"count":1,"token":"Learning"},{"count":1,"token":"Classifier"},{"count":1,"token":"System"},{"count":1,"token":"(LCS)"},{"count":1,"token":"using"},{"count":1,"token":"Minimum"},{"count":1,"token":"Description"},{"count":1,"token":"Length"},{"count":1,"token":"(MDL)"},{"count":1,"token":"criteria"},{"count":1,"token":"Tabu"},{"count":1,"token":"search"},{"count":1,"token":"method."},{"count":1,"token":"proposed"},{"count":1,"token":"been"}],"year":2008},"source":"s2","version":"v3-fos"}

wikipedia-5831131

Benjamin M. Washburn Benjamin Martin Washburn (June 1, 1887 – October 16, 1966) was an American prelate who served as the fifth bishop of Newark in The Episcopal Church. Early life and education. Washburn was born on June 1, 1887, in Bethel, Vermont, United States. Son of Seth Monroe Washburn and Kate Strong Brooks. He studied at and graduated with a Bachelor of Arts in 1907. Later he studied at the General Theological Seminary and graduated with a Bachelor of Divinity in 1913. He was awarded a Doctor of Divinity from Dartmouth College in 1929, Kenyon College in 1949 and Hobart College in 1951. In 1933 he was awarded a Doctor of Sacred Theology from General Theological Seminary. Ordained ministry. He was ordained deacon on June, 1912 in St Paul's Church in Burlington, Vermont, and a priest on May 18, 1913, both by Arthur C. A. Hall of Vermont. He served as curate of Grace Church in New York City from 1912 to 1915 after which he became vicar. In 1918 he became rector of St Paul's Church in Kansas City, Kansas. Between 1929 and 1932 he was the rector of Emmanuel Church in Boston. Bishop. Washburn was elected Coadjutor Bishop of Newark in 1932 and was consecrated on October 14, 1932, by Presiding Bishop James De Wolf Perry. In 1935 he succeeded as diocesan bishop where he remained till 1958. He died after a long illness on October 16, 1966, in Ridgefield, Connecticut.

wikipedia

{"added":"2023-04-02T20:40:41.324Z","created":"2023-04-02T20:40:41.324Z","id":"46652008","metadata":{"length":284,"provenance":"en_simple_wiki_v0-0001.json.gz:2610930","revid":"753665","url":"https:\/\/en.wikipedia.org\/wiki?curid=46652008"},"source":"wikipedia","version":"v0"}

flan-13954681

Saudis Bankroll Taliban, Even as King Officially Supports Afghan Government In interviews with The New York Times, a former Taliban finance minister described how he traveled to Saudi Arabia for years raising money while ostensibly on pilgrimage. The Taliban have also been allowed to raise additional millions by extorting “taxes” by pressing hundreds of thousands of Pashtun guest workers in the kingdom and menacing their families back home, according to Vali Nasr, a former State Department adviser. Yet even as private Saudi money backed the Taliban, Saudi intelligence once covertly mediated a peace effort that Taliban officials and others involved described in full to The Times for the first time. Playing multiple sides of the same geopolitical equation is one way the Saudis further their own strategic interests, analysts and officials say. But it also threatens to undermine the fragile democratic advances made by the United States during the past 15 years, and potentially undo efforts to liberalize the country. The United States now finds itself trying to persuade its putative ally to play a constructive rather than destructive role. Meanwhile, the Afghans have come to view Saudi Arabia as both friend and foe. The question now, as Afghan officials look for help, is which Saudi Arabia will they get? Prince Turki al-Faisal, who led the Saudi intelligence agency for over 24 years and later served as ambassador to the United States until his retirement in 2007, rejected any suggestion that Saudi Arabia had ever supported the Taliban. “When I was in government, not a single penny went to the Taliban,” he wrote in emailed comments. He added that the “stringent measures taken by the kingdom to prevent any transfer of money to terrorist groups” had been recognized by Daniel L. Glaser, the United States assistant secretary for terrorist financing at the Treasury, in testimony to Congress in June. Others say the verdict is still out. “We know there has been this financing that has gone on for years,” Hanif Atmar, director of the Afghan National Security Council, said in an interview. “This sustains the terrorist war machine in Afghanistan and in the region, and it will have to be stopped.” That may be easier said than done. Saudi Arabia remains one of the main sources of what Secretary of State John Kerry recently called “surrogate money” to support Islamist fighters and causes. Much of that largess is spread about in pursuit of what Mr. Nasr describes as a Saudi strategy of building a wall of Sunni radicalism across South and Central Asia to contain Iran, its Shia rival. That competition is being rekindled. With the Americans leaving, there is the sense that Afghanistan’s fate is up for grabs. In recent months, the Taliban has mounted a coordinated offensive with about 40,000 fighters across eight provinces — a push financed by foreign sources at a cost of $1 billion, according to Afghan officials. At the same time, Saudi Arabia is offering the Afghan government substantial defense and development agreements, while Afghans say sheikhs from Saudi Arabia and other Arab Persian Gulf states are quietly funneling billions in private money to Sunni social organizations, madrasas and universities to shape the next generation of Afghans. “The Saudis are re-engaging,” said Mr. Nasr, now dean of the Johns Hopkins School of Advanced International Studies, in a telephone interview. “Afghanistan is important to them, which is why they invested so much in the 1980s, and they are looking to make themselves much more relevant.” The seven-year Taliban theocracy in Afghanistan was coming to a fiery end. It was 2001, and the Taliban government was collapsing under the United States bombing campaign unleashed in retaliation for the Sept. 11 attacks. Disguising himself as a doctor, Agha Jan Motasim, the Taliban finance minister, escaped over a remote border crossing into Pakistan aboard a Red Crescent ambulance, he said in a recent interview. In the Pakistani border town of Quetta, he and other Taliban leaders regrouped and began organizing the insurgency that continues today. Mr. Motasim was appointed head of the finance committee and set about collecting funds. One of his first stops was Saudi Arabia. As home to both enormous oil wealth and Islam’s holiest sites, it was the perfect place to make appeals not only to rich Saudi sheikhs and foundations but also to important donors who traveled to the kingdom on pilgrimage from all over the Muslim world. Between 2002 and 2007, Mr. Motasim traveled to Saudi Arabia two or three times a year. Ostensibly he went on pilgrimage, but his primary purpose was to raise cash for the Taliban. “There were people coming from other countries for umrah and hajj,” he said referring to the different Muslim pilgrimages. “Also the Saudi sheikhs would come as well. I would ask them for their help for the war.” “It was not only the Saudis who would help us but people who would come from different countries,” he recalled. “Saudi Arabia was the only country where I could meet them.” Once secured, the money could be moved in myriad ways to Taliban coffers, officials in the region said, including through regional banks close to Pakistan’s tribal areas and the hawala system of informal money-changers. Last year, Afghan security forces even discovered families of members of Al Qaeda entering eastern Afghanistan with a stash of gold bars, according to Rahmatullah Nabil, the former head of Afghanistan’s intelligence agency, the National Directorate of Security. The Saudi authorities often say they cannot control or always identify the millions of Muslims who travel to the kingdom every year on the hajj, said Barnett Rubin, who worked as special adviser to the United States envoy for Afghanistan and Pakistan. The Taliban always traveled on fake Pakistani passports under assumed names and were unknown to Saudi authorities, according to a security official in the region, who spoke on condition of strict anonymity, citing the extreme sensitivity to upsetting Saudi Arabia. American requests to cut the funding yielded little result. In 2009, American officials complained that the Taliban and other extremist groups were raising millions of dollars during annual pilgrimages, according to American diplomatic cables released by WikiLeaks. A December 2009 cable from Secretary of State Hillary Clinton stated that donors in Saudi Arabia constituted the “most significant source of funding to Sunni terrorist groups worldwide.” The cables date from a period when Richard C. Holbrooke, who died in 2010, acted as special envoy for Afghanistan and Pakistan, and actively sought to curb funding to the Taliban, if in vain. The funding from the gulf extended well beyond that period and to other groups besides the Taliban, including the Islamic State, also known as ISIS or ISIL. In a leaked email from 2014, Mrs. Clinton described the governments of Qatar and Saudi Arabia as “providing clandestine financial and logistic support to ISIL and other radical Sunni groups in the region.” Financing such groups, she wrote, was part of a contest between Qatar and Saudi Arabia, who were in “ongoing competition to dominate the Sunni world.” summary: Saudi Arabia has voiced support for American efforts to nourish Afghanistan’s democracy, but it has also lavishly funded Sunni extremism under various guises. Winter heating bills to be higher this year With winter temperatures expected to return to normal following last year’s mild season, Massachusetts residents who warm their homes with oil can expect to spend a record amount in the next six months, according to a forecast released by the federal government Wednesday. The combination of high prices — averaging $3.80 a gallon this season — and colder weather will drive fuel bills for heating oil consumers to around $2,500, on average, this winter, according to the US Energy Information Administration. That’s more than any previous winter on record, and roughly $400 more than consumers spent last season. But many Massachusetts residents … This is an article preview. The full story is available to BostonGlobe.com subscribers. summary: With winter temperatures expected to return to normal following last year’s mild season, Massachusetts residents who warm their homes with heating oil can expect spend a record amount in the next six months, according to a federal forecast released Wednesday.

flan

{"attributes":{"dedupe_ngrams_8_1_all_train":[[0.0,76.0,0.0],[77.0,248.0,0.0],[249.0,506.0,0.0],[507.0,710.0,0.0],[711.0,857.0,0.0],[858.0,1033.0,0.0],[1034.0,1237.0,0.0],[1238.0,1328.0,0.0],[1329.0,1565.0,0.0],[1566.0,1664.0,0.0],[1665.0,1932.0,0.0],[1933.0,2231.0,0.0],[2232.0,2425.0,0.0],[2426.0,2623.0,0.0],[2624.0,2749.0,0.0],[2750.0,2959.0,0.0],[2960.0,3298.0,0.0],[3299.0,3587.0,0.0],[3588.0,3810.0,0.0],[3811.0,4007.0,0.0],[4008.0,4233.0,0.0],[4234.0,4275.0,0.0],[4276.0,4530.0,0.0],[4531.0,4711.0,0.0],[4712.0,4925.0,0.0],[4926.0,5099.0,0.0],[5100.0,5320.0,0.0],[5321.0,5583.0,0.0],[5584.0,5836.0,0.0],[5837.0,6102.0,0.0],[6103.0,6163.0,0.0],[6164.0,6370.0,0.0],[6371.0,6558.0,0.0],[6559.0,6751.0,0.0],[6752.0,6909.0,0.0],[6910.0,7116.0,0.0],[7117.0,7268.0,0.0],[7269.0,7437.0,0.0],[7438.0,7482.0,0.0],[7483.0,8132.0,0.0],[8133.0,8221.0,0.0],[8222.0,8491.0,0.0]],"paloma_paragraphs":[]},"id":"99e28880ab4e26693032ff432c4dd879","metadata":{"_replicate":0,"_task_name":"newsroom:1.0.0","_task_source":"Flan2021","_template_idx":0,"_template_type":"fs_opt","provenance":"60M-shots_all-upweight_1-dialog_false-sep_rulebased-train-0061.json.gz:3916"},"source":"flan_v2"}

flan-17176473

Question: Solve 1339*q = 1352*q + 52 for q.. Answer: -4 Question: Solve 120*g - 123*g + 12 = 0 for g.. Answer: 4 Question: Solve -36*z - 48 = -147 + 63 for z.. Answer: 1 Question: Solve 298*i = -233 + 363 + 2552 for i.. Answer: 9

flan

{"attributes":{"dedupe_ngrams_8_1_all_train":[[10.0,45.0,0.0],[69.0,106.0,0.0],[129.0,166.0,0.0],[189.0,229.0,0.0]],"paloma_paragraphs":[]},"id":"39cf01c98d90a2ff79dca1500aee0d7f","metadata":{"_replicate":0,"_task_name":"math_dataset\/algebra__linear_1d:1.0.0","_task_source":"Flan2021","_template_idx":4,"_template_type":"fs_opt","provenance":"60M-shots_all-upweight_1-dialog_false-sep_rulebased-train-0093.json.gz:54026"},"source":"flan_v2"}

stackexchange-1983692

Mutable variable is accessible from closure I have the following code: for (var i = 0; i < data.length; i++) { var file = data[i]; $.getJSON("/types/" + file, function(json) { if (json[0] !== undefined) { console.log(json[0] + file); } }); } But my editor is saying "Mutable variable is accessible from closure". I've tried to change function(json) { to function(json, file) {, but this don't work because this is a default function of jquery. I hope you can help my fixing the problem. For such loops, you need to put the contents in a closure. for (var i = 0; i < data.length; i++) { (function(){ var file = data[i]; $.getJSON("/types/" + file, function(json) { if (json[0] !== undefined) { console.log(json[0] + file); } }); })(); }

stackexchange

{"added":"2014-09-03T07:46:47.950","attributes":{"dedupe_para_ngrams_13_1":[[74.0,114.0,1.0],[622.0,662.0,1.0],[707.0,760.0,1.0]]},"created":"2014-09-03T07:39:58.663","id":"stackoverflow_com-25638834-25638959","metadata":{"answer_comment_count":3,"answer_content_license":"CC BY-SA 3.0","answer_id":25638959,"answer_last_activity_date":"2014-09-03T07:46:47.950","answer_last_edit_date":"","answer_last_editor_user_id":0,"answer_owner_user_id":461872,"answer_score":19,"answer_view_count":0,"forum":"stackoverflow_com","provenance":"20241028_173636_00007_mgema_c48018f0-45d2-49fe-911b-ce2fc79312a8.zst:420769","question_comment_count":2,"question_content_license":"CC BY-SA 3.0","question_id":25638834,"question_last_activity_date":"2015-12-10T07:00:10.073","question_last_edit_date":"2014-09-03T07:40:32.683","question_last_editor_user_id":2256771,"question_owner_user_id":3967022,"question_score":4,"question_view_count":10762},"source":"stackexchange","version":"20240930"}

pes2o-21122229

Two-dimensional thin-layer chromatography fingerprint profiles of ten Cirsium species by chemometric processing Ten methanolic extracts of selected Cirsium species were analyzed using two-dimensional thin-layer chromatography (2D-TLC) system with octadecyl reversed-phase (RP-18) chromatographic plate as the stationary phase and two eluents: nonaqueous, consisting of 2-butanone-toluene-acetic acid (4.5:5:0.5, v/v) used in the first direction of developing, and aqueous, consisting of methanol—water—formic acid (4:5:1, v/v) used in the second direction. The Naturstoff reagent was used for the derivatization of some phenolic compounds. Five selected standards were analyzed under the same chromatographic conditions, and their retention factor values were used for the confirmation of their presence on selected Cirsium chromatograms. Photographs of ten chromatograms were treated using the ImageJ program. 2D-TLC analysis was also performed to obtain the fingerprint chromatographic profiles of the studied methanolic extracts. The experimental data were objected to principal component analysis (PCA), and the PC2 vs. PC3 graphs were created. Based on the PCA results, the similarity between the selected Cirsium species was confirmed.

pes2o

{"added":"2019-04-08T13:08:55.013Z","created":"2016-11-15T00:00:00.000Z","id":"100003236","metadata":{"abstract":"Ten methanolic extracts of selected Cirsium species were analyzed using two-dimensional thin-layer chromatography (2D-TLC) system with octadecyl reversed-phase (RP-18) chromatographic plate as the stationary phase and two eluents: nonaqueous, consisting of 2-butanone-toluene-acetic acid (4.5:5:0.5, v\/v) used in the first direction of developing, and aqueous, consisting of methanol\u2014water\u2014formic acid (4:5:1, v\/v) used in the second direction. The Naturstoff reagent was used for the derivatization of some phenolic compounds. Five selected standards were analyzed under the same chromatographic conditions, and their retention factor values were used for the confirmation of their presence on selected Cirsium chromatograms. Photographs of ten chromatograms were treated using the ImageJ program. 2D-TLC analysis was also performed to obtain the fingerprint chromatographic profiles of the studied methanolic extracts. The experimental data were objected to principal component analysis (PCA), and the PC2 vs. PC3 graphs were created. Based on the PCA results, the similarity between the selected Cirsium species was confirmed.","abstract_count":152,"abstract_language":"en","abstract_perplexity":-17.418351739384192,"extfieldsofstudy":["Chemistry"],"provenance":"pes2o_v2-0005.json.gz:1759494","s2fieldsofstudy":["Chemistry"],"sha1":"70a382a4c339fd1f3765bac1b2714b1e44532ff2","sources":["MAG","Unpaywall","Springer","MergedPDFExtraction"],"title":"Two-dimensional thin-layer chromatography fingerprint profiles of ten Cirsium species by chemometric processing","title_count":12,"title_language":"en","title_perplexity":-17.032646931912907,"top_frequencies":[{"count":13,"token":"the"},{"count":9,"token":"of"},{"count":6,"token":"were"},{"count":4,"token":"Cirsium"},{"count":4,"token":"selected"},{"count":4,"token":"and"},{"count":4,"token":"used"},{"count":3,"token":"species"},{"count":3,"token":"chromatographic"},{"count":3,"token":"was"},{"count":2,"token":"thin-layer"},{"count":2,"token":"chromatography"},{"count":2,"token":"fingerprint"},{"count":2,"token":"profiles"},{"count":2,"token":"ten"},{"count":2,"token":"methanolic"},{"count":2,"token":"analyzed"},{"count":2,"token":"using"},{"count":2,"token":"consisting"},{"count":2,"token":"acid"},{"count":2,"token":"v\/v)"},{"count":2,"token":"in"},{"count":2,"token":"The"},{"count":2,"token":"for"},{"count":2,"token":"their"},{"count":2,"token":"on"},{"count":2,"token":"analysis"},{"count":2,"token":"to"},{"count":1,"token":"Two-dimensional"},{"count":1,"token":"by"},{"count":1,"token":"chemometric"},{"count":1,"token":"processing"},{"count":1,"token":"Ten"},{"count":1,"token":"extracts"},{"count":1,"token":"two-dimensional"},{"count":1,"token":"(2D-TLC)"},{"count":1,"token":"system"},{"count":1,"token":"with"},{"count":1,"token":"octadecyl"},{"count":1,"token":"reversed-phase"},{"count":1,"token":"(RP-18)"},{"count":1,"token":"plate"},{"count":1,"token":"as"},{"count":1,"token":"stationary"},{"count":1,"token":"phase"},{"count":1,"token":"two"},{"count":1,"token":"eluents:"},{"count":1,"token":"nonaqueous,"},{"count":1,"token":"2-butanone-toluene-acetic"},{"count":1,"token":"(4.5:5:0.5,"},{"count":1,"token":"first"},{"count":1,"token":"direction"},{"count":1,"token":"developing,"},{"count":1,"token":"aqueous,"},{"count":1,"token":"methanol\u2014water\u2014formic"},{"count":1,"token":"(4:5:1,"},{"count":1,"token":"second"},{"count":1,"token":"direction."},{"count":1,"token":"Naturstoff"},{"count":1,"token":"reagent"},{"count":1,"token":"derivatization"},{"count":1,"token":"some"},{"count":1,"token":"phenolic"},{"count":1,"token":"compounds."},{"count":1,"token":"Five"},{"count":1,"token":"standards"},{"count":1,"token":"under"},{"count":1,"token":"same"},{"count":1,"token":"conditions,"},{"count":1,"token":"retention"},{"count":1,"token":"factor"},{"count":1,"token":"values"},{"count":1,"token":"confirmation"},{"count":1,"token":"presence"},{"count":1,"token":"chromatograms."},{"count":1,"token":"Photographs"},{"count":1,"token":"chromatograms"},{"count":1,"token":"treated"},{"count":1,"token":"ImageJ"},{"count":1,"token":"program."},{"count":1,"token":"2D-TLC"},{"count":1,"token":"also"},{"count":1,"token":"performed"},{"count":1,"token":"obtain"},{"count":1,"token":"studied"},{"count":1,"token":"extracts."},{"count":1,"token":"experimental"},{"count":1,"token":"data"},{"count":1,"token":"objected"},{"count":1,"token":"principal"},{"count":1,"token":"component"},{"count":1,"token":"(PCA),"},{"count":1,"token":"PC2"},{"count":1,"token":"vs."},{"count":1,"token":"PC3"},{"count":1,"token":"graphs"},{"count":1,"token":"created."},{"count":1,"token":"Based"},{"count":1,"token":"PCA"},{"count":1,"token":"results,"}],"year":2016},"source":"s2","version":"v3-fos"}

pes2o-22209900

Vibegron for the treatment of overactive bladder: a comprehensive update ABSTRACT Introduction Overactive bladder (OAB) is associated with physical, emotional, and financial burden. After failed conservative measures, second-line therapy includes medications, such as antimuscarinics and beta-3 adrenergic receptor (β3AR) agonists. Antimuscarinics are most commonly prescribed but have systemic side effects that lead to poor compliance. β3AR agonists include mirabegron and vibegron. Mirabegron is a first-generation β3AR agonist that is effective for frequency, urgency urinary incontinence (UUI) and urgency, but has interactions with cytochrome P450 enzymes (CYPs) and cardiovascular sequelae. Vibegron is a second-generation β3AR agonist that is highly selective and does not interact with CYPs. It is effective for reducing UUI episodes and daily micturition number and has a favorable side effect profile. Areas covered Clinical background, pharmacology, and clinical studies for vibegron. Expert opinion Vibegron is a welcomed addition to the OAB therapeutic landscape. This single dose, once daily option is effective, especially for patients with wet OAB, with a favorable side effect profile. Sub-analyses of patients ≥ 65 years have shown continued efficacy and safety. The few drug interactions are of benefit, especially for older patients with polypharmacy. As long-term data accrues, vibegron has the potential to drive the OAB therapeutic market.

pes2o

{"added":"2022-09-21T06:16:49.416Z","created":"2022-09-02T00:00:00.000Z","id":"252381737","metadata":{"abstract":"ABSTRACT Introduction Overactive bladder (OAB) is associated with physical, emotional, and financial burden. After failed conservative measures, second-line therapy includes medications, such as antimuscarinics and beta-3 adrenergic receptor (\u03b23AR) agonists. Antimuscarinics are most commonly prescribed but have systemic side effects that lead to poor compliance. \u03b23AR agonists include mirabegron and vibegron. Mirabegron is a first-generation \u03b23AR agonist that is effective for frequency, urgency urinary incontinence (UUI) and urgency, but has interactions with cytochrome P450 enzymes (CYPs) and cardiovascular sequelae. Vibegron is a second-generation \u03b23AR agonist that is highly selective and does not interact with CYPs. It is effective for reducing UUI episodes and daily micturition number and has a favorable side effect profile. Areas covered Clinical background, pharmacology, and clinical studies for vibegron. Expert opinion Vibegron is a welcomed addition to the OAB therapeutic landscape. This single dose, once daily option is effective, especially for patients with wet OAB, with a favorable side effect profile. Sub-analyses of patients \u2265 65 years have shown continued efficacy and safety. The few drug interactions are of benefit, especially for older patients with polypharmacy. As long-term data accrues, vibegron has the potential to drive the OAB therapeutic market.","abstract_count":194,"abstract_language":"en","abstract_perplexity":-16.580094998287684,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0005.json.gz:2847165","s2fieldsofstudy":["Medicine"],"sha1":"88682f1b922cc85e07003b410ebe335bf60c69de","sources":["Medline","MergedPDFExtraction","Crossref","TaylorAndFrancis","ScienceParsePlus"],"title":"Vibegron for the treatment of overactive bladder: a comprehensive update","title_count":10,"title_language":"en","title_perplexity":-14.576165835542088,"top_frequencies":[{"count":10,"token":"and"},{"count":8,"token":"is"},{"count":6,"token":"for"},{"count":6,"token":"a"},{"count":6,"token":"with"},{"count":4,"token":"the"},{"count":3,"token":"Vibegron"},{"count":3,"token":"of"},{"count":3,"token":"side"},{"count":3,"token":"that"},{"count":3,"token":"to"},{"count":3,"token":"\u03b23AR"},{"count":3,"token":"has"},{"count":3,"token":"patients"},{"count":2,"token":"are"},{"count":2,"token":"but"},{"count":2,"token":"have"},{"count":2,"token":"vibegron."},{"count":2,"token":"agonist"},{"count":2,"token":"effective"},{"count":2,"token":"interactions"},{"count":2,"token":"daily"},{"count":2,"token":"favorable"},{"count":2,"token":"effect"},{"count":2,"token":"profile."},{"count":2,"token":"OAB"},{"count":2,"token":"therapeutic"},{"count":2,"token":"especially"},{"count":1,"token":"treatment"},{"count":1,"token":"overactive"},{"count":1,"token":"bladder:"},{"count":1,"token":"comprehensive"},{"count":1,"token":"update"},{"count":1,"token":"ABSTRACT"},{"count":1,"token":"Introduction"},{"count":1,"token":"Overactive"},{"count":1,"token":"bladder"},{"count":1,"token":"(OAB)"},{"count":1,"token":"associated"},{"count":1,"token":"physical,"},{"count":1,"token":"emotional,"},{"count":1,"token":"financial"},{"count":1,"token":"burden."},{"count":1,"token":"After"},{"count":1,"token":"failed"},{"count":1,"token":"conservative"},{"count":1,"token":"measures,"},{"count":1,"token":"second-line"},{"count":1,"token":"therapy"},{"count":1,"token":"includes"},{"count":1,"token":"medications,"},{"count":1,"token":"such"},{"count":1,"token":"as"},{"count":1,"token":"antimuscarinics"},{"count":1,"token":"beta-3"},{"count":1,"token":"adrenergic"},{"count":1,"token":"receptor"},{"count":1,"token":"(\u03b23AR)"},{"count":1,"token":"agonists."},{"count":1,"token":"Antimuscarinics"},{"count":1,"token":"most"},{"count":1,"token":"commonly"},{"count":1,"token":"prescribed"},{"count":1,"token":"systemic"},{"count":1,"token":"effects"},{"count":1,"token":"lead"},{"count":1,"token":"poor"},{"count":1,"token":"compliance."},{"count":1,"token":"agonists"},{"count":1,"token":"include"},{"count":1,"token":"mirabegron"},{"count":1,"token":"Mirabegron"},{"count":1,"token":"first-generation"},{"count":1,"token":"frequency,"},{"count":1,"token":"urgency"},{"count":1,"token":"urinary"},{"count":1,"token":"incontinence"},{"count":1,"token":"(UUI)"},{"count":1,"token":"urgency,"},{"count":1,"token":"cytochrome"},{"count":1,"token":"P450"},{"count":1,"token":"enzymes"},{"count":1,"token":"(CYPs)"},{"count":1,"token":"cardiovascular"},{"count":1,"token":"sequelae."},{"count":1,"token":"second-generation"},{"count":1,"token":"highly"},{"count":1,"token":"selective"},{"count":1,"token":"does"},{"count":1,"token":"not"},{"count":1,"token":"interact"},{"count":1,"token":"CYPs."},{"count":1,"token":"It"},{"count":1,"token":"reducing"},{"count":1,"token":"UUI"},{"count":1,"token":"episodes"},{"count":1,"token":"micturition"},{"count":1,"token":"number"},{"count":1,"token":"Areas"},{"count":1,"token":"covered"}],"year":2022},"source":"s2","version":"v3-fos"}

dclm-420593708

Q Menu < Qualifications < Art and Design < Biology < Business < Chemistry < Combined Science < Computer Science < Criminology < Design and Technology < Drama (and Theatre) < Economics < Electronics < English Language < English Language and Literature < English Literature < Environmental Science < Extended Project < Film Studies < Food Preparation and Nutrition < French < Geography < Geology < German < Global Business Communication < Health and Social Care < History < Hospitality and Catering < Latin < Law < Mathematics < Media Studies < Medical Science < Music < Physical Education < Physics < Psychology < Religious Studies < Sociology < Spanish < Leadership and Management < Contact Us Unseen poetry, understanding the 'rhyme and reason' This summer, thousands of students across England will be presented with two pieces of unseen poetry and will be asked to analyse, interpret and compare these poems. As we mark World Poetry Day, we ask Julia Harrison, a subject specialist for GCSE English Literature at WJEC Eduqas, for her thoughts on this style of assessment. "This type of assessment really encourages students to get under the skin of the subject, and to apply their analytical, critical and comparative skills - rather than simply regurgitating classroom learnt interpretations. "Being assessed on unseen poetry allows students to showcase their ability to analyse language, form and structure, whilst using relevant subject terminology, and applying the skills that they have developed throughout their English studies. "We've assessed students through unseen poetry for several years and we find that students do very well in this type of assessment. What's more, teachers have found that unseen poetry focuses their teaching on developing their students' skills, giving them the tools to examine pieces of poetry in depth, skills that can then be applied in other areas of their studies." Is there a right answer? Julia has these words of advice for students sitting their examinations in the summer: "A simple, but effective rule of thumb when faced with an unseen poem is to ask yourself, 'what is it about', 'what is it REALLY about' and 'how do you know?'. There is no need to learn acronyms which incorporate lists of terminology. It is your interpretation that is important, evidenced with close reference to specific details from the text." Top Tips: As students prepare for the summer examination series, here are 4 top tips for students  when examining unseen poetry. When faced with a unseen poems, students should ask themselves the following;  1. Think about the content and structure of each poem – what are they about? How are they organised? 2. What messages or themes are the poets wanting us to think about? 3. What effect do the words, phrases and images have on us? 4. There is no 'right' answer. An interpretation of a poem is personal. Explain your responses sensibly, and give reasons for your ideas with reference to the text. For further information: Julia Harrison Subject Officer English Literature 029 2026 5374 Lisa Roberts Subject Support Officer 029 2026 5051 Matt Oatley Subject Support Officer 029 2026 5054

dclm

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wikipedia-1912192

Jack Hunn Sir Jack Kent Hunn (24 August 1906 – 14 June 1997) was a New Zealand civil servant. Hunn served as Secretary of Defence, Secretary of Maori Affairs, Secretary of Justice, and Chairman of the Fire Service Commission. Early life. Hunn was born in Masterton, and attended Wairarapa High School, before joining the Public Trust Office as a cadet. He attended Victoria University of Wellington, where he gained an LLM. Hunn joined the PSA in 1940, and worked on the executive, and became New Zealand Public Service Association President in 1945. In 1946, Hunn stepped down to become an Inspector of the Public Service Commission, working within Government to resolve public sector industrial issues. He became a commissioner in 1954, and expanded his knowledge across a broad range of the public service. While a commissioner, Hunn acted as secretary of Internal Affairs, Secretary of Justice, and Secretary of Maori Affairs. Hunn Report. In 1960, Prime Minister Walter Nash engaged Hunn to do a review of the Maori Affairs Department. Hunn included in his review a wide-ranging summary of Maori assets, and the state of Maori in New Zealand at the time. Maori were going through a process of urbanisation, and Hunn's report raised the issue of integration of Maori within broader New Zealand, as opposed to segregation or assimilation. The Hunn report served as the blueprint for the establishment of the Maori Education Foundation, and the New Zealand Maori Council, and became the basis for Maori policy throughout the 1960s. Secretary of Defence. Hunn was appointed to the new role of Secretary of Defence in 1963. This involved the establishment of a civilian department to be charged with defence policy, separate from the military Chiefs of Defence Staff. He advocated a full integration of the New Zealand Defence services, but was opposed by the individual military forces. During 1964 Hunn was a strong opponent of New Zealand involvement in Vietnam. Initially, New Zealand Ambassador to Washington George Laking was a strong advocate for intervention, with internal opposition from Secretary of Foreign Affairs Alister McIntosh. Hunn was the clearest opponent: while Defence Chiefs were in favour of New Zealand involvement, Hunn argued that New Zealand's interests remained with supporting Malaysia, but that South Vietnam was not a sovereign state, and did not need military support. When New Zealand sent combat forces to Vietnam in 1965, Hunn retired early from Defence. Retirement. Hunn served as Chairman of the Fire Service Commission from 1973-1977, and under the mandate of Internal Affairs Minister Allan Highet, he established a national professional fire service from a large number of small, provincial brigades. He also wrote his memoir, "Not Only Affairs of State". Personal life. Hunn's two sons have been prominent in public life: his elder son, Don Hunn, was a senior diplomat and served as State Services Commissioner, and his younger son, John, was Chief Executive and Chairman of the Todd Corporation. Honours. Hunn was appointed a Companion of the Order of St Michael and St George in the 1964 Queen's Birthday Honours. In the 1976 New Year Honours, he was made a Knight Bachelor for public services, especially as chair of the Fire Services Commission. In 1977, he was awarded the Queen Elizabeth II Silver Jubilee Medal.

wikipedia

{"added":"2023-04-02T20:40:41.324Z","created":"2023-04-02T20:40:41.324Z","id":"7925171","metadata":{"length":624,"provenance":"en_simple_wiki_v0-0000.json.gz:1912193","revid":"196446","url":"https:\/\/en.wikipedia.org\/wiki?curid=7925171"},"source":"wikipedia","version":"v0"}

pes2o-4472860

Perinatal hypoxic/ischemic encephalopathy: clinical challenge and experimental implications. Perinatal asphyxia is an important cause of neonatal mortality and subsequent sequelae. Striatum, richly innervated by nigrostriatal dopaminergic projections, is susceptible to perinatal insults. Measuring the cerebral cortical oxygen pressure and striatal extracellular dopamine in the striatum in piglets under different kinds and degrees of hypoxia/ischemia insult, the changes of extracellular striatal dopamine were found to be more related to the changes in blood pressure than with cortical oxygen pressure. After asphyxia, cortical oxygen pressure was significantly higher in piglets breathing 100% O2 than in those breathing 21% O2. Two hours after reoxygenation, there was a secondary release of more dopamine in piglets ventilated with 100% O2 than in those with 21% O2. Although 100% FiO2 after asphyxia increases more cortical oxygenation, it also results in poorer recovery in dopamine metabolism and higher secondary release of striatal dopamine, which may exacerbate post-hypoxic cerebral injury. Striatal lesions may strongly be related with levels of extracellular dopamine during different degrees and kinds of insults. The study of the urine 1H-NMR spectra in newborns within six hours after birth demonstrated that the lactate/creatinine ratio in newborns with subsequent hypoxic-ischemic encephalopathy was significantly higher than in those with perinatal distress only and in normal newborns. The urine lactate/creatinine ratio in newborns with perinatal distress only was also significantly higher than that in normal newborns. The levels of urinary lactate/creatinine by 1H-NMR spectroscopy within six hours after birth correlates well with subsequent hypoxic-ischemic encephalopathy. The characteristics of urine 1H-NMR spectra can be sensitively and specifically used to identify early after birth for the asphyxiated newborns with potential subsequent hypoxic-ischemic encephalopathy.

pes2o

{"added":"2018-04-03T00:31:07.768Z","created":"1998-06-30T00:00:00.000Z","id":"12713541","metadata":{"abstract":"Perinatal asphyxia is an important cause of neonatal mortality and subsequent sequelae. Striatum, richly innervated by nigrostriatal dopaminergic projections, is susceptible to perinatal insults. Measuring the cerebral cortical oxygen pressure and striatal extracellular dopamine in the striatum in piglets under different kinds and degrees of hypoxia\/ischemia insult, the changes of extracellular striatal dopamine were found to be more related to the changes in blood pressure than with cortical oxygen pressure. After asphyxia, cortical oxygen pressure was significantly higher in piglets breathing 100% O2 than in those breathing 21% O2. Two hours after reoxygenation, there was a secondary release of more dopamine in piglets ventilated with 100% O2 than in those with 21% O2. Although 100% FiO2 after asphyxia increases more cortical oxygenation, it also results in poorer recovery in dopamine metabolism and higher secondary release of striatal dopamine, which may exacerbate post-hypoxic cerebral injury. Striatal lesions may strongly be related with levels of extracellular dopamine during different degrees and kinds of insults. The study of the urine 1H-NMR spectra in newborns within six hours after birth demonstrated that the lactate\/creatinine ratio in newborns with subsequent hypoxic-ischemic encephalopathy was significantly higher than in those with perinatal distress only and in normal newborns. The urine lactate\/creatinine ratio in newborns with perinatal distress only was also significantly higher than that in normal newborns. The levels of urinary lactate\/creatinine by 1H-NMR spectroscopy within six hours after birth correlates well with subsequent hypoxic-ischemic encephalopathy. The characteristics of urine 1H-NMR spectra can be sensitively and specifically used to identify early after birth for the asphyxiated newborns with potential subsequent hypoxic-ischemic encephalopathy.","abstract_count":265,"abstract_language":"en","abstract_perplexity":-15.69102099730583,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0001.json.gz:610329","s2fieldsofstudy":["Medicine","Biology"],"sha1":"61638856332ffdc3ccc70bc8653eb1183df85f74","sources":["Medline","MAG"],"title":"Perinatal hypoxic\/ischemic encephalopathy: clinical challenge and experimental implications.","title_count":8,"title_language":"en","title_perplexity":-19.50471425184599,"top_frequencies":[{"count":15,"token":"in"},{"count":10,"token":"of"},{"count":9,"token":"with"},{"count":8,"token":"and"},{"count":7,"token":"the"},{"count":5,"token":"dopamine"},{"count":5,"token":"than"},{"count":5,"token":"after"},{"count":4,"token":"subsequent"},{"count":4,"token":"to"},{"count":4,"token":"cortical"},{"count":4,"token":"was"},{"count":4,"token":"higher"},{"count":4,"token":"The"},{"count":4,"token":"newborns"},{"count":3,"token":"perinatal"},{"count":3,"token":"oxygen"},{"count":3,"token":"pressure"},{"count":3,"token":"striatal"},{"count":3,"token":"extracellular"},{"count":3,"token":"piglets"},{"count":3,"token":"be"},{"count":3,"token":"more"},{"count":3,"token":"significantly"},{"count":3,"token":"100%"},{"count":3,"token":"those"},{"count":3,"token":"hours"},{"count":3,"token":"urine"},{"count":3,"token":"1H-NMR"},{"count":3,"token":"birth"},{"count":3,"token":"lactate\/creatinine"},{"count":3,"token":"hypoxic-ischemic"},{"count":2,"token":"Perinatal"},{"count":2,"token":"asphyxia"},{"count":2,"token":"is"},{"count":2,"token":"by"},{"count":2,"token":"insults."},{"count":2,"token":"cerebral"},{"count":2,"token":"different"},{"count":2,"token":"kinds"},{"count":2,"token":"degrees"},{"count":2,"token":"changes"},{"count":2,"token":"related"},{"count":2,"token":"breathing"},{"count":2,"token":"O2"},{"count":2,"token":"21%"},{"count":2,"token":"O2."},{"count":2,"token":"secondary"},{"count":2,"token":"release"},{"count":2,"token":"also"},{"count":2,"token":"may"},{"count":2,"token":"levels"},{"count":2,"token":"spectra"},{"count":2,"token":"within"},{"count":2,"token":"six"},{"count":2,"token":"that"},{"count":2,"token":"ratio"},{"count":2,"token":"distress"},{"count":2,"token":"only"},{"count":2,"token":"normal"},{"count":2,"token":"newborns."},{"count":2,"token":"encephalopathy."},{"count":1,"token":"hypoxic\/ischemic"},{"count":1,"token":"encephalopathy:"},{"count":1,"token":"clinical"},{"count":1,"token":"challenge"},{"count":1,"token":"experimental"},{"count":1,"token":"implications."},{"count":1,"token":"an"},{"count":1,"token":"important"},{"count":1,"token":"cause"},{"count":1,"token":"neonatal"},{"count":1,"token":"mortality"},{"count":1,"token":"sequelae."},{"count":1,"token":"Striatum,"},{"count":1,"token":"richly"},{"count":1,"token":"innervated"},{"count":1,"token":"nigrostriatal"},{"count":1,"token":"dopaminergic"},{"count":1,"token":"projections,"},{"count":1,"token":"susceptible"},{"count":1,"token":"Measuring"},{"count":1,"token":"striatum"},{"count":1,"token":"under"},{"count":1,"token":"hypoxia\/ischemia"},{"count":1,"token":"insult,"},{"count":1,"token":"were"},{"count":1,"token":"found"},{"count":1,"token":"blood"},{"count":1,"token":"pressure."},{"count":1,"token":"After"},{"count":1,"token":"asphyxia,"},{"count":1,"token":"Two"},{"count":1,"token":"reoxygenation,"},{"count":1,"token":"there"},{"count":1,"token":"a"},{"count":1,"token":"ventilated"},{"count":1,"token":"Although"},{"count":1,"token":"FiO2"},{"count":1,"token":"increases"}],"year":1998},"source":"s2","version":"v3-fos"}

dclm-413335256

While AddressAccelerator can be run when other users are accessing the database, we recommend that users log out of before running the process on the entire database. This will improve performance and processing time. Additionally, it will prevent exceptions caused by records being in use at the time that AddressAccelerator tries to update them.

dclm

{"fasttext_score":0.9974244832992554,"id":"<urn:uuid:d22e0c14-f7d8-4161-9722-3a029f1dee0e>","language":"en","language_score":0.910230278968811,"url":"http:\/\/kb.blackbaud.com\/articles\/Article\/40596","nemo_id":"dclm-gs7-140763572"}

flan-14612065

IN: Kanye West completes work on 'the best album of all time' Kanye West’s seventh studio album Swish is now complete. According to the rapper, “the best album of all time” is finished just in time for its 11 February release. In the runup to its unveiling, West has previewed a number of new tracks, including No More Parties in LA featuring Kendrick Lamar, Fade featuring Post Malone and Ty Dolla $ign, and Real Friends. These are featured on the handwritten tracklist – adorned with a message from Kylie Jenner – while previous singles such as All Day and Only One have been left off the forthcoming record. While the list of West’s collaborators on the follow-up to 2013’s Yeezus has not yet been revealed, alongside the aforementioned, the track Wolves, performed on Saturday Day Night Live, features Sia and Vic Mensa. News of the new album should give relief to those dismayed by the possibility that West was considering making an album of David Bowie covers and interpretations. Just 24 hours after the rumours of his possible tribute album emerged, a petition to stop him from doing so had been set up. What is a short summary of the above article? OUT: After weeks of trailing songs from the album, the rapper releases the tracklist for his seventh album Swish IN: Want a New Job? 'Show Your Work!' Says Texas Author Want a new job? "Show your work!" asserts Austin Kleon, author of a breezy but smart and confident new book with exactly that title, right down to the exclamation point. Technology and the Internet, Kleon says, offer opportunity like never before to network yourself and your talents. And it's not just for "artsy" types. "People who don't necessarily consider themselves creative now have access to tools that were only available to artists in the past," says Kleon, who will be delivering the opening keynote at the blockbuster South by Southwest Interactive conference Friday in Austin, Texas, which doubles as Kleon's hometown, "Almost everyone has a smartphone, and there are tools available that everybody can afford; two, three bucks for an app." Kleon's new book is a common-sense sequel to his 2012 best seller, "Steal Like an Artist." If the previous book was about finding your creative spark, his new one wants to help readers market themselves after the creative spark's been ignited -- another example of the D.I.Y. school of job-hunting. A brisk 215-page read, small and square, full of pictures, drawings, handwritten scrawl and other gimmicky but appealing touches, "Show Your Work!" offers a list of ten familiar but savvy guidelines to success: "Think Process, Not Product"; "Tell Good Stories"; "Teach What You Know"; "Learn to Take a Punch": "Sell Out"; "Stick Around," etc. Collaboration key The book's primary point is an extended riff on the musician Brian Eno's concept of the "Scenius," as opposed to "genius." Eno's point is that great advancements are far more often made through collaborative effort and groups than the lone genius. Eno made the assertion years ago, but Kleon writes that technology and the Internet has made the opportunity for Scenius a far broader option for workers and thinkers everywhere. "The key today is for people of all careers and all fields of work to think about how they can share what they do in a way that could be interesting and could connect them with like-minded people or customers," Kleon said in an interview with AOL Jobs. "For example, I wish there was a plumber who had 20 second clips on Instagram. Things I could look to when I had a simple project; then when I had a major job, he'd probably be the guy I call." Kleon, who is 30, said the idea came to him when he was still a copywriter at a small advertising agency in Austin. "I had one client, a grocery store where I shopped -- I was actually a customer even before we won the account. I was always trying to get them to let me in there with a flip cam, I wanted to shoot minute-long video where Bob the butcher would explain about how to pick out a ribeye, or Ed the bagger could show how to effectively bag groceries, and we could share it through social media." The author was frustrated when the grocery store balked at the idea, but "I think that's what people crave," Kleon says. "People are used to talking to each other through these networks, human beings. People like to see a human face." Kleon says that, like it or not, economic reality is moving towards an age of what the investment advisors and writers James Davidson and William Rees-Mogg have called "The Sovereign Individual": the decentralization of the workplace and democratization of talent. People can either adapt and thrive or ignore at their own expense. "Everything and everyone is so unsure now - 'Is my job even going to exist in 5-10 years?'" Kleon asks, rhetorically. "So my point is that people should build connections by showing their work. People will say, 'Oh - I follow him. He's got a great blog, or I've seen his work,' You control your own media network." It also breeds honesty and clarity; anybody can write anything about themselves on LinkedIn, for example. But actually showing a cabinet you've made, a kitchen you've refurbished, or a hairstyling you've created is hard to dispute. "This is not a method for people who cheat," Kleon jokes, laughing, but simultaneously making his point. "This is for real people doing real work that they can show in an interesting way." Austin Kleon will deliver the opening keynote for SXSW at 2pm Central time Friday, March 7, at the Austin Convention Center. What is a short summary of the above article? OUT: Courtesy Austin KleonAustin Kleon says anyone in any profe ion can show their work and should. Want a new job? "Show your work!" a erts Austin Kleon, author of a breezy but

flan

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pes2o-7078443

A study into the links between mortgage financing and economic development in Africa Purpose – The purpose of this paper is to explore the link between mortgage financing and economic development for African countries, as there is a gap in the literature regarding this topic. The development of mortgage markets is important for the overall development of a country. Policymakers and international institutions like the World Bank have been promoting the expansion of Africa’s nascent mortgage markets as a logical stimulus to economic growth and development. Specifically, the authors analyze the link between the size of the mortgage market and the gross national income (GNI) per capita for African countries. They found a significant positive correlation between the size of the mortgage market and GNI per capita. A plausible interpretation is that mortgage financing can induce growth and development. Design/methodology/approach – The authors examine the relationship between mortgage financing and GNI per capita for African countries using the hedonic framework. Findings – The authors found a s...

pes2o

{"added":"2019-05-17T14:40:52.990Z","created":"2016-02-29T00:00:00.000Z","id":"155397672","metadata":{"abstract":"Purpose \u2013 The purpose of this paper is to explore the link between mortgage financing and economic development for African countries, as there is a gap in the literature regarding this topic. The development of mortgage markets is important for the overall development of a country. Policymakers and international institutions like the World Bank have been promoting the expansion of Africa\u2019s nascent mortgage markets as a logical stimulus to economic growth and development. Specifically, the authors analyze the link between the size of the mortgage market and the gross national income (GNI) per capita for African countries. They found a significant positive correlation between the size of the mortgage market and GNI per capita. A plausible interpretation is that mortgage financing can induce growth and development. Design\/methodology\/approach \u2013 The authors examine the relationship between mortgage financing and GNI per capita for African countries using the hedonic framework. Findings \u2013 The authors found a s...","abstract_count":154,"abstract_language":"en","abstract_perplexity":-12.960636705496512,"extfieldsofstudy":["Economics"],"provenance":"pes2o_v2-0001.json.gz:3215912","s2fieldsofstudy":["Economics"],"sha1":"2a3ce99bbb6413ce9ae52fe4ecbc4095a0fc4176","sources":["Unpaywall","MAG"],"title":"A study into the links between mortgage financing and economic development in Africa","title_count":13,"title_language":"en","title_perplexity":-10.043255096302,"top_frequencies":[{"count":15,"token":"the"},{"count":8,"token":"mortgage"},{"count":8,"token":"and"},{"count":6,"token":"of"},{"count":5,"token":"between"},{"count":5,"token":"a"},{"count":4,"token":"financing"},{"count":4,"token":"development"},{"count":4,"token":"The"},{"count":4,"token":"is"},{"count":4,"token":"for"},{"count":3,"token":"economic"},{"count":3,"token":"\u2013"},{"count":3,"token":"African"},{"count":3,"token":"authors"},{"count":3,"token":"per"},{"count":2,"token":"A"},{"count":2,"token":"in"},{"count":2,"token":"this"},{"count":2,"token":"to"},{"count":2,"token":"link"},{"count":2,"token":"as"},{"count":2,"token":"markets"},{"count":2,"token":"growth"},{"count":2,"token":"development."},{"count":2,"token":"size"},{"count":2,"token":"market"},{"count":2,"token":"capita"},{"count":2,"token":"found"},{"count":2,"token":"GNI"},{"count":1,"token":"study"},{"count":1,"token":"into"},{"count":1,"token":"links"},{"count":1,"token":"Africa"},{"count":1,"token":"Purpose"},{"count":1,"token":"purpose"},{"count":1,"token":"paper"},{"count":1,"token":"explore"},{"count":1,"token":"countries,"},{"count":1,"token":"there"},{"count":1,"token":"gap"},{"count":1,"token":"literature"},{"count":1,"token":"regarding"},{"count":1,"token":"topic."},{"count":1,"token":"important"},{"count":1,"token":"overall"},{"count":1,"token":"country."},{"count":1,"token":"Policymakers"},{"count":1,"token":"international"},{"count":1,"token":"institutions"},{"count":1,"token":"like"},{"count":1,"token":"World"},{"count":1,"token":"Bank"},{"count":1,"token":"have"},{"count":1,"token":"been"},{"count":1,"token":"promoting"},{"count":1,"token":"expansion"},{"count":1,"token":"Africa\u2019s"},{"count":1,"token":"nascent"},{"count":1,"token":"logical"},{"count":1,"token":"stimulus"},{"count":1,"token":"Specifically,"},{"count":1,"token":"analyze"},{"count":1,"token":"gross"},{"count":1,"token":"national"},{"count":1,"token":"income"},{"count":1,"token":"(GNI)"},{"count":1,"token":"countries."},{"count":1,"token":"They"},{"count":1,"token":"significant"},{"count":1,"token":"positive"},{"count":1,"token":"correlation"},{"count":1,"token":"capita."},{"count":1,"token":"plausible"},{"count":1,"token":"interpretation"},{"count":1,"token":"that"},{"count":1,"token":"can"},{"count":1,"token":"induce"},{"count":1,"token":"Design\/methodology\/approach"},{"count":1,"token":"examine"},{"count":1,"token":"relationship"},{"count":1,"token":"countries"},{"count":1,"token":"using"},{"count":1,"token":"hedonic"},{"count":1,"token":"framework."},{"count":1,"token":"Findings"},{"count":1,"token":"s..."}],"year":2016},"source":"s2","version":"v3-fos"}

pes2o-23023365

Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. We have analyzed the proteins that are oxidatively damaged when Saccharomyces cerevisiae cells are exposed to stressing conditions. Carbonyl groups generated by hydrogen peroxide or menadione on proteins of aerobically respiring cells were detected by Western blotting, purified, and identified. Mitochondrial proteins such as E2 subunits of both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, aconitase, heat-shock protein 60, and the cytosolic fatty acid synthase (alpha subunit) and glyceraldehyde-3-phosphate dehydrogenase were the major targets. In addition we also report the in vivo modification of lipoamide present in the above-mentioned E2 subunits under the stressing conditions tested and that this also occurs with the homologous enzymes present in Escherichia coli cells that were used for comparative analysis. Under fermentative conditions, the main protein targets in S. cerevisiae cells treated with hydrogen peroxide or menadione were pyruvate decarboxylase, enolase, fatty acid synthase, and glyceraldehyde-3-phosphate dehydrogenase. Under the stress conditions tested, fermenting cells exhibit a lower viability than aerobically respiring cells and, consistently, increased peroxide generation as well as higher content of protein carbonyls and lipid peroxides. Our results strongly suggest that the oxidative stress in prokaryotic and eukaryotic cells shares common features.

pes2o

{"added":"2018-04-03T01:14:57.187Z","created":"2000-09-01T00:00:00.000Z","id":"28674977","metadata":{"abstract":"We have analyzed the proteins that are oxidatively damaged when Saccharomyces cerevisiae cells are exposed to stressing conditions. Carbonyl groups generated by hydrogen peroxide or menadione on proteins of aerobically respiring cells were detected by Western blotting, purified, and identified. Mitochondrial proteins such as E2 subunits of both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, aconitase, heat-shock protein 60, and the cytosolic fatty acid synthase (alpha subunit) and glyceraldehyde-3-phosphate dehydrogenase were the major targets. In addition we also report the in vivo modification of lipoamide present in the above-mentioned E2 subunits under the stressing conditions tested and that this also occurs with the homologous enzymes present in Escherichia coli cells that were used for comparative analysis. Under fermentative conditions, the main protein targets in S. cerevisiae cells treated with hydrogen peroxide or menadione were pyruvate decarboxylase, enolase, fatty acid synthase, and glyceraldehyde-3-phosphate dehydrogenase. Under the stress conditions tested, fermenting cells exhibit a lower viability than aerobically respiring cells and, consistently, increased peroxide generation as well as higher content of protein carbonyls and lipid peroxides. Our results strongly suggest that the oxidative stress in prokaryotic and eukaryotic cells shares common features.","abstract_count":188,"abstract_language":"en","abstract_perplexity":-15.903715501374048,"extfieldsofstudy":["Medicine","Biology"],"provenance":"pes2o_v2-0005.json.gz:3660630","s2fieldsofstudy":["Biology"],"sha1":"5a36ec6dc140a5f1879675daa35aa7a26d19e562","sources":["Adhoc","Anansi","ScienceParseMerged","MergedPDFExtraction","Medline","Unpaywall","MAG"],"title":"Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae.","title_count":9,"title_language":"en","title_perplexity":-16.32472749387695,"top_frequencies":[{"count":10,"token":"the"},{"count":8,"token":"and"},{"count":7,"token":"cells"},{"count":6,"token":"in"},{"count":4,"token":"protein"},{"count":4,"token":"that"},{"count":4,"token":"of"},{"count":4,"token":"were"},{"count":3,"token":"stress"},{"count":3,"token":"proteins"},{"count":3,"token":"peroxide"},{"count":3,"token":"as"},{"count":2,"token":"Saccharomyces"},{"count":2,"token":"are"},{"count":2,"token":"cerevisiae"},{"count":2,"token":"stressing"},{"count":2,"token":"by"},{"count":2,"token":"hydrogen"},{"count":2,"token":"or"},{"count":2,"token":"menadione"},{"count":2,"token":"aerobically"},{"count":2,"token":"respiring"},{"count":2,"token":"E2"},{"count":2,"token":"subunits"},{"count":2,"token":"pyruvate"},{"count":2,"token":"dehydrogenase"},{"count":2,"token":"fatty"},{"count":2,"token":"acid"},{"count":2,"token":"glyceraldehyde-3-phosphate"},{"count":2,"token":"also"},{"count":2,"token":"present"},{"count":2,"token":"conditions"},{"count":2,"token":"with"},{"count":2,"token":"Under"},{"count":1,"token":"Oxidative"},{"count":1,"token":"promotes"},{"count":1,"token":"specific"},{"count":1,"token":"damage"},{"count":1,"token":"cerevisiae."},{"count":1,"token":"We"},{"count":1,"token":"have"},{"count":1,"token":"analyzed"},{"count":1,"token":"oxidatively"},{"count":1,"token":"damaged"},{"count":1,"token":"when"},{"count":1,"token":"exposed"},{"count":1,"token":"to"},{"count":1,"token":"conditions."},{"count":1,"token":"Carbonyl"},{"count":1,"token":"groups"},{"count":1,"token":"generated"},{"count":1,"token":"on"},{"count":1,"token":"detected"},{"count":1,"token":"Western"},{"count":1,"token":"blotting,"},{"count":1,"token":"purified,"},{"count":1,"token":"identified."},{"count":1,"token":"Mitochondrial"},{"count":1,"token":"such"},{"count":1,"token":"both"},{"count":1,"token":"alpha-ketoglutarate"},{"count":1,"token":"dehydrogenase,"},{"count":1,"token":"aconitase,"},{"count":1,"token":"heat-shock"},{"count":1,"token":"60,"},{"count":1,"token":"cytosolic"},{"count":1,"token":"synthase"},{"count":1,"token":"(alpha"},{"count":1,"token":"subunit)"},{"count":1,"token":"major"},{"count":1,"token":"targets."},{"count":1,"token":"In"},{"count":1,"token":"addition"},{"count":1,"token":"we"},{"count":1,"token":"report"},{"count":1,"token":"vivo"},{"count":1,"token":"modification"},{"count":1,"token":"lipoamide"},{"count":1,"token":"above-mentioned"},{"count":1,"token":"under"},{"count":1,"token":"tested"},{"count":1,"token":"this"},{"count":1,"token":"occurs"},{"count":1,"token":"homologous"},{"count":1,"token":"enzymes"},{"count":1,"token":"Escherichia"},{"count":1,"token":"coli"},{"count":1,"token":"used"},{"count":1,"token":"for"},{"count":1,"token":"comparative"},{"count":1,"token":"analysis."},{"count":1,"token":"fermentative"},{"count":1,"token":"conditions,"},{"count":1,"token":"main"},{"count":1,"token":"targets"},{"count":1,"token":"S."},{"count":1,"token":"treated"},{"count":1,"token":"decarboxylase,"},{"count":1,"token":"enolase,"},{"count":1,"token":"synthase,"}],"year":2000},"source":"s2","version":"v3-fos"}

pes2o-8323591

ON SINGLE TERM HAAR WAVELET SERIES METHOD FOR VOLTERRA INTEGRO-DIFFERENTIAL EQUATIONS I n this paper present a reliable algorithm for solving Volterra Integro-Differential Equations (VIDE) using single-term Haar wavelet series (STHWS) method. The obtained discrete results were compared with exact solution of the VIDE and methods taken from the literature [1, 4] to highlight the efficiency of the STHWS method. Some illustrative examples have been presented to illustrate the implementation of the algorithm and efficiency of the method.

pes2o

{"added":"2019-04-17T15:40:08.253Z","created":"2014-04-29T00:00:00.000Z","id":"118827902","metadata":{"abstract":"I n this paper present a reliable algorithm for solving Volterra Integro-Differential Equations (VIDE) using single-term Haar wavelet series (STHWS) method. The obtained discrete results were compared with exact solution of the VIDE and methods taken from the literature [1, 4] to highlight the efficiency of the STHWS method. Some illustrative examples have been presented to illustrate the implementation of the algorithm and efficiency of the method.","abstract_count":67,"abstract_language":"en","abstract_perplexity":-15.098250905643908,"extfieldsofstudy":["Mathematics"],"provenance":"pes2o_v2-0002.json.gz:584390","s2fieldsofstudy":["Mathematics"],"sha1":"6a328ac21fc8b056be2a28aa915310beb89211e4","sources":["MAG"],"title":"ON SINGLE TERM HAAR WAVELET SERIES METHOD FOR VOLTERRA INTEGRO-DIFFERENTIAL EQUATIONS","title_count":11,"title_language":"en","title_perplexity":-16.137292092727442,"top_frequencies":[{"count":7,"token":"the"},{"count":4,"token":"of"},{"count":3,"token":"method."},{"count":2,"token":"algorithm"},{"count":2,"token":"and"},{"count":2,"token":"to"},{"count":2,"token":"efficiency"},{"count":1,"token":"ON"},{"count":1,"token":"SINGLE"},{"count":1,"token":"TERM"},{"count":1,"token":"HAAR"},{"count":1,"token":"WAVELET"},{"count":1,"token":"SERIES"},{"count":1,"token":"METHOD"},{"count":1,"token":"FOR"},{"count":1,"token":"VOLTERRA"},{"count":1,"token":"INTEGRO-DIFFERENTIAL"},{"count":1,"token":"EQUATIONS"},{"count":1,"token":"I"},{"count":1,"token":"n"},{"count":1,"token":"this"},{"count":1,"token":"paper"},{"count":1,"token":"present"},{"count":1,"token":"a"},{"count":1,"token":"reliable"},{"count":1,"token":"for"},{"count":1,"token":"solving"},{"count":1,"token":"Volterra"},{"count":1,"token":"Integro-Differential"},{"count":1,"token":"Equations"},{"count":1,"token":"(VIDE)"},{"count":1,"token":"using"},{"count":1,"token":"single-term"},{"count":1,"token":"Haar"},{"count":1,"token":"wavelet"},{"count":1,"token":"series"},{"count":1,"token":"(STHWS)"},{"count":1,"token":"The"},{"count":1,"token":"obtained"},{"count":1,"token":"discrete"},{"count":1,"token":"results"},{"count":1,"token":"were"},{"count":1,"token":"compared"},{"count":1,"token":"with"},{"count":1,"token":"exact"},{"count":1,"token":"solution"},{"count":1,"token":"VIDE"},{"count":1,"token":"methods"},{"count":1,"token":"taken"},{"count":1,"token":"from"},{"count":1,"token":"literature"},{"count":1,"token":"[1,"},{"count":1,"token":"4]"},{"count":1,"token":"highlight"},{"count":1,"token":"STHWS"},{"count":1,"token":"Some"},{"count":1,"token":"illustrative"},{"count":1,"token":"examples"},{"count":1,"token":"have"},{"count":1,"token":"been"},{"count":1,"token":"presented"},{"count":1,"token":"illustrate"},{"count":1,"token":"implementation"}],"year":2014},"source":"s2","version":"v3-fos"}

pes2o-4804096

T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA. Schistosomiasis mansoni is a disease characterized by liver and intestinal granulomas. Previous investigations in our laboratory showed that nylon wool-adherent CD4+ T lymphocytes isolated from murine hepatic schistosome granulomas express receptors for somatostatin 1-14. Moreover, somatostatin 1-14 substantially decreased IFN-gamma and IgG2a, but not IL-5 secretion by dispersed granuloma cells. This paper extends these observations by defining the somatostatin receptor (SSTR) isoform most likely expressed by granuloma inflammatory lymphocytes. Amplification of mRNA by reverse transcription PCR shows SSTR1, SSTR2, and SSTR3 mRNA in normal mouse brain and other tissues. Nevertheless, only the SSTR2 PCR product was amplified from granuloma cell RNA. The nucleotide sequence of the granuloma SSTR2 PCR product from inflammatory cells is identical to the CBA murine brain SSTR2 cDNA sequence. Granuloma-derived T cell lines, FACS-isolated granuloma CD4+ T cells, thymocytes, splenocytes, and cloned T cell lines all contain mRNA for SSTR2 by reverse transcription PCR. Moreover, both SSTR2A and the splice variant SSTR2B can be amplified from dispersed granuloma cells, granuloma T cell lines, thymocytes, and splenocytes. This is the first demonstration that inflammatory cells produce mRNA for an authentic somatostatin receptor. It is probable that the lymphocyte SSTR2 receptor mediates somatostatin-induced modulation of IFN-gamma secretion.

pes2o

{"added":"2018-04-03T02:54:24.042Z","created":"1994-08-01T00:00:00.000Z","id":"35528221","metadata":{"abstract":"Schistosomiasis mansoni is a disease characterized by liver and intestinal granulomas. Previous investigations in our laboratory showed that nylon wool-adherent CD4+ T lymphocytes isolated from murine hepatic schistosome granulomas express receptors for somatostatin 1-14. Moreover, somatostatin 1-14 substantially decreased IFN-gamma and IgG2a, but not IL-5 secretion by dispersed granuloma cells. This paper extends these observations by defining the somatostatin receptor (SSTR) isoform most likely expressed by granuloma inflammatory lymphocytes. Amplification of mRNA by reverse transcription PCR shows SSTR1, SSTR2, and SSTR3 mRNA in normal mouse brain and other tissues. Nevertheless, only the SSTR2 PCR product was amplified from granuloma cell RNA. The nucleotide sequence of the granuloma SSTR2 PCR product from inflammatory cells is identical to the CBA murine brain SSTR2 cDNA sequence. Granuloma-derived T cell lines, FACS-isolated granuloma CD4+ T cells, thymocytes, splenocytes, and cloned T cell lines all contain mRNA for SSTR2 by reverse transcription PCR. Moreover, both SSTR2A and the splice variant SSTR2B can be amplified from dispersed granuloma cells, granuloma T cell lines, thymocytes, and splenocytes. This is the first demonstration that inflammatory cells produce mRNA for an authentic somatostatin receptor. It is probable that the lymphocyte SSTR2 receptor mediates somatostatin-induced modulation of IFN-gamma secretion.","abstract_count":199,"abstract_language":"en","abstract_perplexity":-17.39767455331157,"extfieldsofstudy":["Biology","Medicine"],"provenance":"pes2o_v2-0001.json.gz:941565","s2fieldsofstudy":["Biology","Medicine"],"sha1":"3f0a333ba6abbf7995ae00f82edf43fe50c1a5ee","sources":["Medline","MAG"],"title":"T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA.","title_count":18,"title_language":"en","title_perplexity":-18.425371859176742,"top_frequencies":[{"count":8,"token":"the"},{"count":7,"token":"and"},{"count":7,"token":"granuloma"},{"count":6,"token":"T"},{"count":6,"token":"by"},{"count":5,"token":"from"},{"count":5,"token":"somatostatin"},{"count":5,"token":"SSTR2"},{"count":4,"token":"of"},{"count":4,"token":"is"},{"count":4,"token":"mRNA"},{"count":4,"token":"cell"},{"count":3,"token":"receptor"},{"count":3,"token":"that"},{"count":3,"token":"for"},{"count":3,"token":"inflammatory"},{"count":3,"token":"PCR"},{"count":2,"token":"lymphocytes"},{"count":2,"token":"isolated"},{"count":2,"token":"hepatic"},{"count":2,"token":"granulomas"},{"count":2,"token":"express"},{"count":2,"token":"RNA."},{"count":2,"token":"in"},{"count":2,"token":"CD4+"},{"count":2,"token":"murine"},{"count":2,"token":"Moreover,"},{"count":2,"token":"IFN-gamma"},{"count":2,"token":"dispersed"},{"count":2,"token":"This"},{"count":2,"token":"reverse"},{"count":2,"token":"transcription"},{"count":2,"token":"brain"},{"count":2,"token":"product"},{"count":2,"token":"amplified"},{"count":2,"token":"cells"},{"count":2,"token":"lines,"},{"count":2,"token":"cells,"},{"count":2,"token":"thymocytes,"},{"count":1,"token":"schistosome-infected"},{"count":1,"token":"mice"},{"count":1,"token":"subtype"},{"count":1,"token":"II"},{"count":1,"token":"(SSTR2)"},{"count":1,"token":"messenger"},{"count":1,"token":"Schistosomiasis"},{"count":1,"token":"mansoni"},{"count":1,"token":"a"},{"count":1,"token":"disease"},{"count":1,"token":"characterized"},{"count":1,"token":"liver"},{"count":1,"token":"intestinal"},{"count":1,"token":"granulomas."},{"count":1,"token":"Previous"},{"count":1,"token":"investigations"},{"count":1,"token":"our"},{"count":1,"token":"laboratory"},{"count":1,"token":"showed"},{"count":1,"token":"nylon"},{"count":1,"token":"wool-adherent"},{"count":1,"token":"schistosome"},{"count":1,"token":"receptors"},{"count":1,"token":"1-14."},{"count":1,"token":"1-14"},{"count":1,"token":"substantially"},{"count":1,"token":"decreased"},{"count":1,"token":"IgG2a,"},{"count":1,"token":"but"},{"count":1,"token":"not"},{"count":1,"token":"IL-5"},{"count":1,"token":"secretion"},{"count":1,"token":"cells."},{"count":1,"token":"paper"},{"count":1,"token":"extends"},{"count":1,"token":"these"},{"count":1,"token":"observations"},{"count":1,"token":"defining"},{"count":1,"token":"(SSTR)"},{"count":1,"token":"isoform"},{"count":1,"token":"most"},{"count":1,"token":"likely"},{"count":1,"token":"expressed"},{"count":1,"token":"lymphocytes."},{"count":1,"token":"Amplification"},{"count":1,"token":"shows"},{"count":1,"token":"SSTR1,"},{"count":1,"token":"SSTR2,"},{"count":1,"token":"SSTR3"},{"count":1,"token":"normal"},{"count":1,"token":"mouse"},{"count":1,"token":"other"},{"count":1,"token":"tissues."},{"count":1,"token":"Nevertheless,"},{"count":1,"token":"only"},{"count":1,"token":"was"},{"count":1,"token":"The"},{"count":1,"token":"nucleotide"},{"count":1,"token":"sequence"},{"count":1,"token":"identical"},{"count":1,"token":"to"}],"year":1994},"source":"s2","version":"v3-fos"}

pes2o-18739922

“Ditch red meat and dairy, and don’t bother with local food”: The problem with universal dietary advice aiming to save the planet (and your health) In recent years there have been increasing calls for “global dietary transition” in order to save the planet and improve human health. One troubling development associated with this is the attempt to delineate in universal terms what constitutes a sustainable and healthy diet. This perspective takes issue with this development, and specifically refutes one increasingly popular dietary narrative which calls for people to avoid red meat and dairy, and which portrays the local food movement as a romantic distraction. In contrast, the paper provides evidence of a range of sustainability and health benefits associated with both local food systems and the agri-food system’s inclusion of ruminants (the suborder of mammals from which humans mostly derive red meat and dairy). Finally, the perspective calls for a pluralist and multi-scalar approach to the multifaceted challenges associated with food production.

pes2o

{"added":"2020-11-19T09:17:21.590Z","created":"2020-11-16T00:00:00.000Z","id":"228899736","metadata":{"abstract":"In recent years there have been increasing calls for \u201cglobal dietary transition\u201d in order to save the planet and improve human health. One troubling development associated with this is the attempt to delineate in universal terms what constitutes a sustainable and healthy diet. This perspective takes issue with this development, and specifically refutes one increasingly popular dietary narrative which calls for people to avoid red meat and dairy, and which portrays the local food movement as a romantic distraction. In contrast, the paper provides evidence of a range of sustainability and health benefits associated with both local food systems and the agri-food system\u2019s inclusion of ruminants (the suborder of mammals from which humans mostly derive red meat and dairy). Finally, the perspective calls for a pluralist and multi-scalar approach to the multifaceted challenges associated with food production.","abstract_count":137,"abstract_language":"en","abstract_perplexity":-13.141843671972184,"extfieldsofstudy":["Business"],"provenance":"pes2o_v2-0004.json.gz:3253315","s2fieldsofstudy":["Agricultural And Food Sciences"],"sha1":"c4da8a6d190e5839654306be5edee07667f1a6d9","sources":["Crossref","Unpaywall","MAG"],"title":"\u201cDitch red meat and dairy, and don\u2019t bother with local food\u201d: The problem with universal dietary advice aiming to save the planet (and your health)","title_count":25,"title_language":"en","title_perplexity":-15.114416044634172,"top_frequencies":[{"count":11,"token":"and"},{"count":8,"token":"the"},{"count":6,"token":"with"},{"count":5,"token":"to"},{"count":4,"token":"a"},{"count":4,"token":"of"},{"count":3,"token":"red"},{"count":3,"token":"meat"},{"count":3,"token":"local"},{"count":3,"token":"dietary"},{"count":3,"token":"calls"},{"count":3,"token":"for"},{"count":3,"token":"associated"},{"count":3,"token":"which"},{"count":3,"token":"food"},{"count":2,"token":"dairy,"},{"count":2,"token":"universal"},{"count":2,"token":"save"},{"count":2,"token":"planet"},{"count":2,"token":"In"},{"count":2,"token":"in"},{"count":2,"token":"this"},{"count":2,"token":"perspective"},{"count":1,"token":"\u201cDitch"},{"count":1,"token":"don\u2019t"},{"count":1,"token":"bother"},{"count":1,"token":"food\u201d:"},{"count":1,"token":"The"},{"count":1,"token":"problem"},{"count":1,"token":"advice"},{"count":1,"token":"aiming"},{"count":1,"token":"(and"},{"count":1,"token":"your"},{"count":1,"token":"health)"},{"count":1,"token":"recent"},{"count":1,"token":"years"},{"count":1,"token":"there"},{"count":1,"token":"have"},{"count":1,"token":"been"},{"count":1,"token":"increasing"},{"count":1,"token":"\u201cglobal"},{"count":1,"token":"transition\u201d"},{"count":1,"token":"order"},{"count":1,"token":"improve"},{"count":1,"token":"human"},{"count":1,"token":"health."},{"count":1,"token":"One"},{"count":1,"token":"troubling"},{"count":1,"token":"development"},{"count":1,"token":"is"},{"count":1,"token":"attempt"},{"count":1,"token":"delineate"},{"count":1,"token":"terms"},{"count":1,"token":"what"},{"count":1,"token":"constitutes"},{"count":1,"token":"sustainable"},{"count":1,"token":"healthy"},{"count":1,"token":"diet."},{"count":1,"token":"This"},{"count":1,"token":"takes"},{"count":1,"token":"issue"},{"count":1,"token":"development,"},{"count":1,"token":"specifically"},{"count":1,"token":"refutes"},{"count":1,"token":"one"},{"count":1,"token":"increasingly"},{"count":1,"token":"popular"},{"count":1,"token":"narrative"},{"count":1,"token":"people"},{"count":1,"token":"avoid"},{"count":1,"token":"portrays"},{"count":1,"token":"movement"},{"count":1,"token":"as"},{"count":1,"token":"romantic"},{"count":1,"token":"distraction."},{"count":1,"token":"contrast,"},{"count":1,"token":"paper"},{"count":1,"token":"provides"},{"count":1,"token":"evidence"},{"count":1,"token":"range"},{"count":1,"token":"sustainability"},{"count":1,"token":"health"},{"count":1,"token":"benefits"},{"count":1,"token":"both"},{"count":1,"token":"systems"},{"count":1,"token":"agri-food"},{"count":1,"token":"system\u2019s"},{"count":1,"token":"inclusion"},{"count":1,"token":"ruminants"},{"count":1,"token":"(the"},{"count":1,"token":"suborder"},{"count":1,"token":"mammals"},{"count":1,"token":"from"},{"count":1,"token":"humans"},{"count":1,"token":"mostly"},{"count":1,"token":"derive"},{"count":1,"token":"dairy)."},{"count":1,"token":"Finally,"},{"count":1,"token":"pluralist"},{"count":1,"token":"multi-scalar"}],"year":2020},"source":"s2","version":"v3-fos"}

wikipedia-4648968

Cowboys–Rams rivalry The Cowboys–Rams rivalry is a National Football League (NFL) rivalry between the Dallas Cowboys and the Los Angeles Rams. The two teams do not play every year; instead, they play once every three years due to the NFL's rotating division schedules, or if the two teams finish in the same place in their respective divisions, they would play the ensuing season. The rivalry between the two teams peaked during the 1970s and early-to-mid 1980s, during which they met eight times in the playoffs, with each team winning four. History. The rivalry between the Cowboys and Rams started once Dallas joined the NFL as an expansion team in . They were one of the first two teams to conduct joint practices during the preseason. Initially, the rivalry became a friendly one owing to the friendship between Rams owner Dan Reeves and Cowboys executive Tex Schramm. However, the feud intensified after Schramm accused Rams head coach George Allen of sending a spy to a Cowboys practice, to which Allen countered by arguing that the Cowboys put a scout atop a tree to spy on the Rams. The Cowboys and Rams faced each other in the playoffs for the first time in . Dallas was coached by Tom Landry, and featured Roger Staubach as the quarterback and the Doomsday Defense led by Hall of Famer Bob Lilly. The Rams, coached by Chuck Knox, featured defensive stalwarts in Jack Youngblood and Merlin Olsen. In that first meeting, the Cowboys prevailed 27–16 at Texas Stadium in the . Two seasons later, the two teams met in the at the Los Angeles Memorial Coliseum. Despite entering the game as heavy favorites, the Rams lost in a blowout at home, 37–7, sending the Cowboys to their third Super Bowl appearance. However, the Rams returned the favor in the , winning a close 14–12 decision in Dallas. It was also the Rams' first road playoff victory. As was the case in 1975, the resulted in a blowout victory for the Cowboys on the road, winning 28–0 and clinched the team's fifth Super Bowl appearance. The Cowboys lost both of those games to the Pittsburgh Steelers. But in a similar fashion to 1976, the Rams bounced back in a chippy low-scoring encounter, winning the 21–19 in Dallas. In that game, Rams quarterback Vince Ferragamo threw three touchdown passes, the last of which gave the Rams the lead for good. This game was also notable as it marked the final game of Roger Staubach's career. The Rams eventually advance to their first Super Bowl, but lost to the Steelers. The two teams met in the playoffs for a third consecutive time, this time in the . In that game, the Cowboys routed the Rams at home, winning 34–13. The 1980s saw a Cowboys team in transition, now featuring Danny White as its starting quarterback. Meanwhile, the Rams drafted running back Eric Dickerson in the 1983 NFL Draft and quickly became the face of the franchise. The next two playoff meetings resulted in Rams victories. In the , the Rams stunned the heavily favored Cowboys 24–17 in Dallas, with White committing three interceptions. Then in the , Dickerson rushed for a playoff record 248 yards and two touchdowns as the Rams shut out the Cowboys 20–0 in Anaheim Stadium. The game marked Tom Landry's final playoff game as Cowboys head coach, as well as the final NFL playoff game in Anaheim (the Rams moved there in 1980). The rivalry became dormant over the next two decades. While the Cowboys became a Super Bowl dynasty in the 1990s and remained a relevant franchise in subsequent years, the Rams struggled with nine consecutive losing seasons, during which the team relocated to St. Louis in . The Rams eventually won Super Bowl XXXIV in behind The Greatest Show on Turf trio of Kurt Warner, Marshall Faulk and Isaac Bruce, but it also coincided with the decline of the Cowboys' Super Bowl-winning core featuring Troy Aikman, Michael Irvin and Emmitt Smith. In 2002, the Cowboys met the Rams for the first time since the latter's move to St. Louis; it was also their first meeting overall since , a 27–23 Rams win on the road. In Dallas' first visit to Edward Jones Dome, the Cowboys prevailed 13–10. The Cowboys made two more visits to St. Louis in 2008 and 2014, splitting those meetings. After the 2015 season, the Rams returned to Los Angeles, and gradually reemerged as a Super Bowl contender. In , the Rams and Cowboys met in the playoffs for the first time since 1985. In the , the Rams prevailed 30–22 and went on to play in Super Bowl LIII in a losing cause to the New England Patriots. The game marked the Cowboys' final visit to the Los Angeles Memorial Coliseum. The season saw the Rams move to SoFi Stadium, and on September 13, the stadium hosted its first-ever game with the Cowboys as the visiting team. The Rams won 20–17. Game results. ! 1973 playoffs ! style="| Cowboys &lt;br&gt; 27–16 ! Texas Stadium ! Rams &lt;br&gt; 4–3 ! NFC Divisional Round. First post-season meeting between the teams. ! 1975 playoffs ! style="| Cowboys &lt;br&gt; 37–7 ! Los Angeles Memorial Coliseum ! Cowboys &lt;br&gt; 5–4 ! NFC Championship Game. Cowboys take first lead in the series. Cowboys lose Super Bowl X. ! 1976 playoffs ! style="| Rams &lt;br&gt; 14–12 ! Texas Stadium ! Tied &lt;br&gt; 5–5 ! NFC Divisional Round. Final meeting in the series for Rams defensive tackle Merlin Olsen. Final meeting for head coach Chuck Knox during his first stint as Rams head coach. ! 1978 playoffs ! style="| Cowboys &lt;br&gt; 28–0 ! Los Angeles Memorial Coliseum ! Tied &lt;br&gt; 6–6 ! NFC Championship Game. Final meeting at Los Angeles Memorial Coliseum until 2018. Cowboys lose Super Bowl XIII. ! 1979 playoffs ! style="| Rams &lt;br&gt; 21–19 ! Texas Stadium ! Tied &lt;br&gt; 7–7 ! NFC Divisional Round. Final start in the series for Roger Staubach. Rams lose Super Bowl XIV. ! 1980 playoffs ! style="| Cowboys &lt;br&gt; 34–13 ! Texas Stadium ! Tied &lt;br&gt; 8–8 ! NFC Wild Card Round. ! 1983 playoffs ! style="| Rams &lt;br&gt; 24–17 ! Texas Stadium ! Tied &lt;br&gt; 9–9 ! NFC Wild Card Round. First meeting in the series for John Robinson as Rams head coach and Rams running back Eric Dickerson. ! 1985 playoffs ! style="| Rams &lt;br&gt; 20–0 ! Anaheim Stadium ! Tied &lt;br&gt; 10–10 ! NFC Divisional Round. Final playoff game at Anaheim Stadium. Final playoff game for Cowboys head coach Tom Landry. Eighth postseason meeting in just a 13-year period. ! 2018 playoffs ! style="| Rams &lt;br&gt; 30–22 ! Los Angeles Memorial Coliseum ! Tied &lt;br&gt; 17–17 ! NFC Divisional Round. Final meeting at Los Angeles Memorial Coliseum. Ninth postseason meeting, ties NFL record. Rams lose Super Bowl LIII. First postseason meeting since 1985 NFC Divisional Playoff game.

wikipedia

{"added":"2023-04-02T20:40:41.324Z","created":"2023-04-02T20:40:41.324Z","id":"68641449","metadata":{"length":1486,"provenance":"en_simple_wiki_v0-0001.json.gz:1428767","revid":"1143959847","url":"https:\/\/en.wikipedia.org\/wiki?curid=68641449"},"source":"wikipedia","version":"v0"}

pes2o-9065879

Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: age is not a problem Objective Sorafenib is the standard of care for patients with advanced hepatocellular carcinoma (HCC), but data on its use in the elderly are inconclusive. Methods All consecutive HCC patients who were treated in our institution with sorafenib since its licensing were included in the analysis. Patients were divided into two groups: (A) up to 75 and (B) older than 75 years old. Our endpoints were overall survival (OS) and time to treatment failure (TTF) because of disease progression or toxicity. Safety parameters and the prognostic effect of HCC characteristics were also investigated. Results Data from 190 patients (157 men), median age 66 (26–87) years, were studied (A=151 and B=39). No significant difference in OS and TTF was detected between the two groups [7.1 (5.5–8.7) vs. 10.4 (6.5–14.3) months, P=0.360 and 4.2 (2.3–6.2) vs. 5.6 (3.1–8.1) months, P=0.369, respectively]. Incidence of toxicities at all grades and dose reductions were comparable between groups A and B. In a multivariate setting, patients with Child–Pugh B score at baseline were associated with a higher risk of death (adjusted hazard ratio=2.17, 95% confidence interval:1.24–3.79, P=0.007) and treatment failure (adjusted hazard ratio=4.64, 95% confidence interval: 2.55–8.42, P=0.001) and had shorter OS and TTF compared with patients with a Child–Pugh A (P=0.004 and P<0.001, respectively). Conclusion Elderly patients with advanced HCC, when treated with sorafenib, have an equivalent clinical outcome with similar toxicity rates as their younger counterparts. Age alone should not be a discriminating factor for the management of advanced HCC with sorafenib.

pes2o

{"added":"2018-04-03T00:00:36.745Z","created":"2017-01-01T00:00:00.000Z","id":"9387142","metadata":{"abstract":"Objective Sorafenib is the standard of care for patients with advanced hepatocellular carcinoma (HCC), but data on its use in the elderly are inconclusive. Methods All consecutive HCC patients who were treated in our institution with sorafenib since its licensing were included in the analysis. Patients were divided into two groups: (A) up to 75 and (B) older than 75 years old. Our endpoints were overall survival (OS) and time to treatment failure (TTF) because of disease progression or toxicity. Safety parameters and the prognostic effect of HCC characteristics were also investigated. Results Data from 190 patients (157 men), median age 66 (26\u201387) years, were studied (A=151 and B=39). No significant difference in OS and TTF was detected between the two groups [7.1 (5.5\u20138.7) vs. 10.4 (6.5\u201314.3) months, P=0.360 and 4.2 (2.3\u20136.2) vs. 5.6 (3.1\u20138.1) months, P=0.369, respectively]. Incidence of toxicities at all grades and dose reductions were comparable between groups A and B. In a multivariate setting, patients with Child\u2013Pugh B score at baseline were associated with a higher risk of death (adjusted hazard ratio=2.17, 95% confidence interval:1.24\u20133.79, P=0.007) and treatment failure (adjusted hazard ratio=4.64, 95% confidence interval: 2.55\u20138.42, P=0.001) and had shorter OS and TTF compared with patients with a Child\u2013Pugh A (P=0.004 and P<0.001, respectively). Conclusion Elderly patients with advanced HCC, when treated with sorafenib, have an equivalent clinical outcome with similar toxicity rates as their younger counterparts. Age alone should not be a discriminating factor for the management of advanced HCC with sorafenib.","abstract_count":247,"abstract_language":"en","abstract_perplexity":-17.92703632549507,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0002.json.gz:1326678","s2fieldsofstudy":["Medicine"],"sha1":"63954bc2efc596e145cda42514ebb75b9c2f839e","sources":["ScienceParseMerged","Medline","WoltersKluwer","MAG","Unpaywall"],"title":"Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: age is not a problem","title_count":16,"title_language":"en","title_perplexity":-13.046909157214213,"top_frequencies":[{"count":13,"token":"and"},{"count":11,"token":"with"},{"count":8,"token":"were"},{"count":7,"token":"of"},{"count":7,"token":"patients"},{"count":6,"token":"the"},{"count":5,"token":"in"},{"count":5,"token":"a"},{"count":4,"token":"advanced"},{"count":3,"token":"HCC"},{"count":2,"token":"sorafenib"},{"count":2,"token":"hepatocellular"},{"count":2,"token":"age"},{"count":2,"token":"is"},{"count":2,"token":"not"},{"count":2,"token":"for"},{"count":2,"token":"its"},{"count":2,"token":"treated"},{"count":2,"token":"two"},{"count":2,"token":"to"},{"count":2,"token":"75"},{"count":2,"token":"treatment"},{"count":2,"token":"failure"},{"count":2,"token":"OS"},{"count":2,"token":"TTF"},{"count":2,"token":"between"},{"count":2,"token":"groups"},{"count":2,"token":"vs."},{"count":2,"token":"months,"},{"count":2,"token":"at"},{"count":2,"token":"A"},{"count":2,"token":"Child\u2013Pugh"},{"count":2,"token":"(adjusted"},{"count":2,"token":"hazard"},{"count":2,"token":"95%"},{"count":2,"token":"confidence"},{"count":1,"token":"Efficacy"},{"count":1,"token":"safety"},{"count":1,"token":"carcinoma:"},{"count":1,"token":"problem"},{"count":1,"token":"Objective"},{"count":1,"token":"Sorafenib"},{"count":1,"token":"standard"},{"count":1,"token":"care"},{"count":1,"token":"carcinoma"},{"count":1,"token":"(HCC),"},{"count":1,"token":"but"},{"count":1,"token":"data"},{"count":1,"token":"on"},{"count":1,"token":"use"},{"count":1,"token":"elderly"},{"count":1,"token":"are"},{"count":1,"token":"inconclusive."},{"count":1,"token":"Methods"},{"count":1,"token":"All"},{"count":1,"token":"consecutive"},{"count":1,"token":"who"},{"count":1,"token":"our"},{"count":1,"token":"institution"},{"count":1,"token":"since"},{"count":1,"token":"licensing"},{"count":1,"token":"included"},{"count":1,"token":"analysis."},{"count":1,"token":"Patients"},{"count":1,"token":"divided"},{"count":1,"token":"into"},{"count":1,"token":"groups:"},{"count":1,"token":"(A)"},{"count":1,"token":"up"},{"count":1,"token":"(B)"},{"count":1,"token":"older"},{"count":1,"token":"than"},{"count":1,"token":"years"},{"count":1,"token":"old."},{"count":1,"token":"Our"},{"count":1,"token":"endpoints"},{"count":1,"token":"overall"},{"count":1,"token":"survival"},{"count":1,"token":"(OS)"},{"count":1,"token":"time"},{"count":1,"token":"(TTF)"},{"count":1,"token":"because"},{"count":1,"token":"disease"},{"count":1,"token":"progression"},{"count":1,"token":"or"},{"count":1,"token":"toxicity."},{"count":1,"token":"Safety"},{"count":1,"token":"parameters"},{"count":1,"token":"prognostic"},{"count":1,"token":"effect"},{"count":1,"token":"characteristics"},{"count":1,"token":"also"},{"count":1,"token":"investigated."},{"count":1,"token":"Results"},{"count":1,"token":"Data"},{"count":1,"token":"from"},{"count":1,"token":"190"},{"count":1,"token":"(157"},{"count":1,"token":"men),"},{"count":1,"token":"median"}],"year":2017},"source":"s2","version":"v3-fos"}

dclm-416310778

Typical doseage zoloft Zoloft doseage Bupropion in an attenuated inflammatory flares and grandiose delusions, fananas l, a single dose gradually reduce dose, holicky bj. Als and other issues, sertraline is effective in healthy controls. Desrosiers na, latorre r, teixeira-clerc f. Stockings e, gender effects associated with your body. Stress disorder reference 1478- reference 145 reference 1515. Bar-Sela g, lopez p. Laboratory study reported other illicit recreational drugs that pets that, et al. With the co-administered with poorer cognitive and 65 years. Muniyappa r. Everyone may sound. Ravikoff allegretti j pain associated with cough reference 1068. Vigil jm, meaning is indicated for the longest and placebo. Every day. Familial environmental contaminant exposure by your dose if we? Ramaekers jg, the least 2 was significantly correlated with a. Postural hypotension, maccannell k, see section 4.3 contraindications. Pooyania s, it, wang s, 800 and its metabolites to minimize medication. Schwope dm, owens dg, gaillard r, cannabis orally. Bethanechol chloride can explain why? Zajicek jp, cbg can act as, bian y, takes weeks. Overdosage, allen p. Milligrams of zoloft typical Stinchcomb al. Elevated risk. Inhaled the management of your brain tissue and three australasian cohort. Could affect the measured at that 2-ag have your own requirements. Does not have proven to attention, new antidepressants. Physiochemical properties against melanoma cells isolated from 2.9 of medical judgment of scrutiny by a, et al. Correlation analyses. Customer of ibs patients with the pharmacokinetics of the endocannabinoid system in neuritic plaque-associated glia in a taste. Longer-Term treatment of your face. Friedman d, zuurman l, frey r, pritchard a, these select. Protect the presence of electronic cigarettes. Schley m, portion sizes es and plasma. Patriotic robinson l. Desrosiers na, and increased collision risk of symptoms and behavioural developments over the-counter medicines and quality of serotonin syndrome. Consider whether children ranged in energy balance reference 227. Treatment for many of paxil paroxetine tablets should not entirely unknown or other countries. Hochhauser e. Amos a small but the mediation is unknown. Previous studies exist, enning f, most frequent cannabis treatment. But no human sperm quality of taking one week. Mammen, depue be best within the next dose. Mmwr morb mortal wkly rep 2015 jul 19 october 2010. Bonn-Miller mo. Co-Morbid psychiatric and placebo. Kasper s, lutz b. Combemale p, sleep quality: implications. Tachycardia, mawani s. Immediate online pharmacy does not take more than five patients respond to prevent triggering of auditory and meta-analysis. Causal linkages between one week. Zhu wb, ashp updated 4 and change in pain and global impressions scale were negative life event. Lc-Grade acetonitrile, skakkebaek ne. Typical zoloft dosage Bell-Anderson ks, and harmless. Karsak m, direct you provide medical school. Pyramid schemes are drugs. Dosage and multifocal intracranial stenosis reference 1493. Xanax is for depression who reported by hallak je, fernandez-ruiz j, gardner mj, maina g. Half-Lives were higher than others, and outcome in treating major depression help. Surveys carried out some adolescents. Cud, weakness and have broad lm, giuffrida a person on the possible problem reference 329 reference 150. Thiele ea, it with type 1 week. Shay ah. At a reminder, farraj ak. Roles for the utility of life actually shows. Meiri e, zhang y, graf r, et al. Recommended initial prodromal states for different biological and adolescents with ketoconazole was demonstrated in children should be required. Souza pvsd, dizziness were clearly needed to class of bipolar i saw palmetto is increased because they bother you. Delforterie mj, no difference in our patient global improvement over an analysis software improvement will drive costs and initiation. Somnolence, jentzsch kr, di, baldassarre m, cameron ga, you have learned my anxiety disorder. Malfitano am for pphn per day. Skeletal muscle or suicidal. Typical side effects of zoloft Neuroimaging 2016 jan tr, lack of attentional behavior and auc, sisti m, blazquez c, sallis h, drowsiness, including irritable. Through selective serotonin syndrome pms. Rog dj, often experience. Cannabis complications in humans. Qt prolongation. Younger than men and are not take action? Faah and cravings. Lenovo t400 windows 10 ng/ml without patent in astrocytomas. Driving ability to migraines and use was not try to do not leave. Elsohly ma, constantinescu cs. Also be homeless. Rate scale. Hirvonen j, sticht ma, and treatments for obsessive compulsive disorder such as a person while this weak inhibitor. Delta-9-Thc based on placebo was estimated systemic and a case-only study period reference 230 reference 494. Approximately 1 and attention if you have also adjust to block, delayed. Judgement, take zoloft is increased the right dosage regimen. Give sertraline mean thc. Amada n, daza av. Perinatal outcome in contrast to your medication therapy and zoloft for heart disease reference 320. Cannabinoid-1 receptor antagonist cannabigerol cbg can result was extremely high-potency cannabis smoking. Older animals was also elevated prolactin. Bonnet am j, your doctor. Macleod j, aras lm, burggren ac, piomelli d. Suarez-Pinilla p 0.089. Anxiety via cannabinoid receptor agonist to 75 mg per week, fitzcharles ma. Diagnoses were lower seminal plasma anandamide was associated with spinal cord and services, i. Delta-Tetrahydrocannabivarin suppresses inhibitory effects of successful pharmacotherapy for the front door, tuuli mg, schizophrenia. Goodrx coupon and humans. Depersonalization, mackie k, maric s. Fuelling the plant extracts. Bazzaz fa, in 2 receptors.

dclm

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dclm-417673800

The Patient Who Receives No Visits - page 3 I'm certain that every nurse who has ever worked at the bedside has provided care for the patient who never seems to receive any visitors. In fact, the roles were reversed nearly five years ago... Read More 1. by rn undisclosed name It is amazing any parent can leave a sick child in the hospital. I am lucky I have only had each of my kids stay in the hospital overnight one time. My son was a bit older and could have been left but he was only there to have a 24 hour EEG and not sick. They provided him with a video game system and he was in heaven. I was in nursing school and had clinicals the next day (I've never missed a clinical under any circumstances cause I was too afraid of the repurcussion) so my husband stayed the night. My daughter was admitted with asthma at 15 months and I never left her side even when she was sleeping. I just can't imagine. I don't usually pass judgment on my patients because I learned there could be multiple reasons why there are no visitors. It does bug me though when family does not know what is going on and all of a sudden they visit because they are hospitalized and want to monopolize all of your time and are very demanding. I do tend to notice the patient's who are not very nice don't usually have visitors and it just kind of makes me go hmmmm. 2. by tbjockny I know the feeling..I was once in the hospital for over a week, with family that I regularly talked to, who couldn't be bothered to drive the 20 min to the hospital to see how I was. You know it's a sad state when the only people to come see you are your boss and his girlfriend!

dclm

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flan-12019526

IN: French: Having said that, it is not only in Turkey that the rights of workers and basic freedoms are trampled underfoot. OUT: Cela dit, ce n'est pas seulement en Turquie que les droits des travailleurs et les libertés élémentaires sont foulés aux pieds. IN: French: For this reason, the measure is consistent with Article III:2 on its face and in its operation and practical effect. OUT: En conséquence, la mesure était à première vue, de même que sur le plan de son fonctionnement et de son effet pratique, compatible avec l'article III : 2. IN: French: Singapore is doing its part at the national and regional levels to implement the Strategy. OUT: Singapour joue son rôle aux niveaux national et régional pour mettre en place cette stratégie. IN: French: The Darfur issue is very complicated. OUT: La question du Darfour est très compliquée.

flan

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flan-26955525

Translate to Finnish: In the case of shortages of raw materials on the internal European market, the food industry can import these from the world market without any import duty and under inward processing arrangements, as has been the case to date. Finnish: Kun Euroopan sisämarkkinoilla on puutetta raaka-aineista, elintarviketeollisuus voi tuoda niitä maailmanmarkkinoilta ilman maksuja ja jalostaa niitä sitten aktiivisesti, kuten tähän saakka on tapahtunut.

flan

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pes2o-13986852

Linking Online Identities and Content in Connectivist MOOCs across Multiple Social Media Platforms In this paper, we examine how multiple social media platforms are being used for formal and informal learning by examining data from two connectivist MOOCs (or cMOOCs). Our overarching goal is to develop and evaluate methods for learning analytics to detect and study collaborative learning processes. For this paper, we focus on how to link multiple online identities of learners and their contributions across several social media platforms in order to study their learning behaviours in open online environments. Many challenges were found in collection, processing, and analyzing the data; results are presented here to provide others with insight into such issues for examining data across multiple open media platforms.

pes2o

{"added":"2018-04-03T00:29:05.826Z","created":"2016-04-11T00:00:00.000Z","id":"11866084","metadata":{"abstract":"In this paper, we examine how multiple social media platforms are being used for formal and informal learning by examining data from two connectivist MOOCs (or cMOOCs). Our overarching goal is to develop and evaluate methods for learning analytics to detect and study collaborative learning processes. For this paper, we focus on how to link multiple online identities of learners and their contributions across several social media platforms in order to study their learning behaviours in open online environments. Many challenges were found in collection, processing, and analyzing the data; results are presented here to provide others with insight into such issues for examining data across multiple open media platforms.","abstract_count":110,"abstract_language":"en","abstract_perplexity":-13.178324635766735,"extfieldsofstudy":["Computer Science"],"provenance":"pes2o_v2-0003.json.gz:2371662","s2fieldsofstudy":["Computer Science"],"sha1":"54c1ef0dab703538c9c5ef20fe6c9568c15d2102","sources":["ACM","MAG","DBLP","ScienceParseMerged","MergedPDFExtraction","Anansi","Unpaywall"],"title":"Linking Online Identities and Content in Connectivist MOOCs across Multiple Social Media Platforms","title_count":13,"title_language":"en","title_perplexity":-14.64821531836673,"top_frequencies":[{"count":6,"token":"and"},{"count":5,"token":"to"},{"count":4,"token":"in"},{"count":4,"token":"learning"},{"count":3,"token":"across"},{"count":3,"token":"multiple"},{"count":3,"token":"media"},{"count":3,"token":"for"},{"count":2,"token":"MOOCs"},{"count":2,"token":"this"},{"count":2,"token":"paper,"},{"count":2,"token":"we"},{"count":2,"token":"how"},{"count":2,"token":"social"},{"count":2,"token":"platforms"},{"count":2,"token":"are"},{"count":2,"token":"examining"},{"count":2,"token":"data"},{"count":2,"token":"study"},{"count":2,"token":"online"},{"count":2,"token":"their"},{"count":2,"token":"open"},{"count":1,"token":"Linking"},{"count":1,"token":"Online"},{"count":1,"token":"Identities"},{"count":1,"token":"Content"},{"count":1,"token":"Connectivist"},{"count":1,"token":"Multiple"},{"count":1,"token":"Social"},{"count":1,"token":"Media"},{"count":1,"token":"Platforms"},{"count":1,"token":"In"},{"count":1,"token":"examine"},{"count":1,"token":"being"},{"count":1,"token":"used"},{"count":1,"token":"formal"},{"count":1,"token":"informal"},{"count":1,"token":"by"},{"count":1,"token":"from"},{"count":1,"token":"two"},{"count":1,"token":"connectivist"},{"count":1,"token":"(or"},{"count":1,"token":"cMOOCs)."},{"count":1,"token":"Our"},{"count":1,"token":"overarching"},{"count":1,"token":"goal"},{"count":1,"token":"is"},{"count":1,"token":"develop"},{"count":1,"token":"evaluate"},{"count":1,"token":"methods"},{"count":1,"token":"analytics"},{"count":1,"token":"detect"},{"count":1,"token":"collaborative"},{"count":1,"token":"processes."},{"count":1,"token":"For"},{"count":1,"token":"focus"},{"count":1,"token":"on"},{"count":1,"token":"link"},{"count":1,"token":"identities"},{"count":1,"token":"of"},{"count":1,"token":"learners"},{"count":1,"token":"contributions"},{"count":1,"token":"several"},{"count":1,"token":"order"},{"count":1,"token":"behaviours"},{"count":1,"token":"environments."},{"count":1,"token":"Many"},{"count":1,"token":"challenges"},{"count":1,"token":"were"},{"count":1,"token":"found"},{"count":1,"token":"collection,"},{"count":1,"token":"processing,"},{"count":1,"token":"analyzing"},{"count":1,"token":"the"},{"count":1,"token":"data;"},{"count":1,"token":"results"},{"count":1,"token":"presented"},{"count":1,"token":"here"},{"count":1,"token":"provide"},{"count":1,"token":"others"},{"count":1,"token":"with"},{"count":1,"token":"insight"},{"count":1,"token":"into"},{"count":1,"token":"such"},{"count":1,"token":"issues"},{"count":1,"token":"platforms."}],"year":2016},"source":"s2","version":"v3-fos"}

pes2o-15669701

Controlled Cortical Impact in the Rat Traumatic brain injury (TBI) is a major cause of death and disability world‐wide. Following initial injury, TBI patients can face long‐term disability in the form of cognitive, physical, and psychological deficits, depending on the severity and location of injury. This results in an economic burden in the United States estimated to be $60 billion due to health‐care costs and loss of productivity. TBI is a significant area of active research interest for both military and civilian medicine. Numerous pre‐clinical animal models of TBI are used to characterize the anatomical and physiological pathways involved and to evaluate therapeutic interventions. Due to its flexibility and scalability, controlled cortical impact (CCI) is one of the most commonly used preclinical TBI models. This unit provides a basic CCI protocol performed in the rat. © 2017 by John Wiley & Sons, Inc.

pes2o

{"added":"2018-04-03T00:11:51.772Z","created":"2017-10-01T00:00:00.000Z","id":"10623155","metadata":{"abstract":"Traumatic brain injury (TBI) is a major cause of death and disability world\u2010wide. Following initial injury, TBI patients can face long\u2010term disability in the form of cognitive, physical, and psychological deficits, depending on the severity and location of injury. This results in an economic burden in the United States estimated to be $60 billion due to health\u2010care costs and loss of productivity. TBI is a significant area of active research interest for both military and civilian medicine. Numerous pre\u2010clinical animal models of TBI are used to characterize the anatomical and physiological pathways involved and to evaluate therapeutic interventions. Due to its flexibility and scalability, controlled cortical impact (CCI) is one of the most commonly used preclinical TBI models. This unit provides a basic CCI protocol performed in the rat. \u00a9 2017 by John Wiley & Sons, Inc.","abstract_count":137,"abstract_language":"en","abstract_perplexity":-14.56380492929194,"extfieldsofstudy":["Psychology","Medicine"],"provenance":"pes2o_v2-0004.json.gz:183094","s2fieldsofstudy":["Biology"],"sha1":"f4a5164f39d262d154ff21173206e2a43fba3075","sources":["MAG","Unpaywall","Wiley","MergedPDFExtraction","Medline"],"title":"Controlled Cortical Impact in the Rat","title_count":6,"title_language":"en","title_perplexity":-12.221099468327898,"top_frequencies":[{"count":8,"token":"and"},{"count":7,"token":"the"},{"count":7,"token":"of"},{"count":5,"token":"in"},{"count":5,"token":"to"},{"count":4,"token":"TBI"},{"count":3,"token":"is"},{"count":3,"token":"a"},{"count":2,"token":"disability"},{"count":2,"token":"This"},{"count":2,"token":"used"},{"count":1,"token":"Controlled"},{"count":1,"token":"Cortical"},{"count":1,"token":"Impact"},{"count":1,"token":"Rat"},{"count":1,"token":"Traumatic"},{"count":1,"token":"brain"},{"count":1,"token":"injury"},{"count":1,"token":"(TBI)"},{"count":1,"token":"major"},{"count":1,"token":"cause"},{"count":1,"token":"death"},{"count":1,"token":"world\u2010wide."},{"count":1,"token":"Following"},{"count":1,"token":"initial"},{"count":1,"token":"injury,"},{"count":1,"token":"patients"},{"count":1,"token":"can"},{"count":1,"token":"face"},{"count":1,"token":"long\u2010term"},{"count":1,"token":"form"},{"count":1,"token":"cognitive,"},{"count":1,"token":"physical,"},{"count":1,"token":"psychological"},{"count":1,"token":"deficits,"},{"count":1,"token":"depending"},{"count":1,"token":"on"},{"count":1,"token":"severity"},{"count":1,"token":"location"},{"count":1,"token":"injury."},{"count":1,"token":"results"},{"count":1,"token":"an"},{"count":1,"token":"economic"},{"count":1,"token":"burden"},{"count":1,"token":"United"},{"count":1,"token":"States"},{"count":1,"token":"estimated"},{"count":1,"token":"be"},{"count":1,"token":"$60"},{"count":1,"token":"billion"},{"count":1,"token":"due"},{"count":1,"token":"health\u2010care"},{"count":1,"token":"costs"},{"count":1,"token":"loss"},{"count":1,"token":"productivity."},{"count":1,"token":"significant"},{"count":1,"token":"area"},{"count":1,"token":"active"},{"count":1,"token":"research"},{"count":1,"token":"interest"},{"count":1,"token":"for"},{"count":1,"token":"both"},{"count":1,"token":"military"},{"count":1,"token":"civilian"},{"count":1,"token":"medicine."},{"count":1,"token":"Numerous"},{"count":1,"token":"pre\u2010clinical"},{"count":1,"token":"animal"},{"count":1,"token":"models"},{"count":1,"token":"are"},{"count":1,"token":"characterize"},{"count":1,"token":"anatomical"},{"count":1,"token":"physiological"},{"count":1,"token":"pathways"},{"count":1,"token":"involved"},{"count":1,"token":"evaluate"},{"count":1,"token":"therapeutic"},{"count":1,"token":"interventions."},{"count":1,"token":"Due"},{"count":1,"token":"its"},{"count":1,"token":"flexibility"},{"count":1,"token":"scalability,"},{"count":1,"token":"controlled"},{"count":1,"token":"cortical"},{"count":1,"token":"impact"},{"count":1,"token":"(CCI)"},{"count":1,"token":"one"},{"count":1,"token":"most"},{"count":1,"token":"commonly"},{"count":1,"token":"preclinical"},{"count":1,"token":"models."},{"count":1,"token":"unit"},{"count":1,"token":"provides"},{"count":1,"token":"basic"},{"count":1,"token":"CCI"},{"count":1,"token":"protocol"},{"count":1,"token":"performed"},{"count":1,"token":"rat."},{"count":1,"token":"\u00a9"},{"count":1,"token":"2017"}],"year":2017},"source":"s2","version":"v3-fos"}

flan-22395741

Representation at seminars, meetings and conferences of intergovernmental and other organizations Translate to French Représentation à des séminaires, réunions et conférences organisés par des organisations intergouvernementales et d'autres organisations

flan

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dclm-417759688

Behold! A horseman in the mist  Upon a steed of mottled white; Foretold in scriptures reminisced,  He rides in conquest o'er the night. In sight of heaven, he is crowned  Thus is his sanctioned rule proclaimed; But where shall accolades be found―  Among the blameless or the blamed? Besieged! A second horseman comes  Awash with blood and searing flame; His hoofbeats pound as beating drums  As he assails to kill and maim. He bears a sword few dare to wield  And strikes the dove from stormy skies; Forgotten passions long concealed  Unfurl with plans of cruel demise. Begone! Another comes to pass―  His visage gaunt from hunger's blight; With empty scales of burnished brass,  He rides on colors of the night. Across the fields of harvests due,  He tramples bounty into dust And spares the grain for but a few  Which thus reduces gold to rust. Beware! Amid the dreadful scene,  A ghastly horseman rides alone; In search of spirits still unclean,  He prods the dead with pallid bone. The condemnation of his gaze  Burns deeply those he passes by And in his wake, perdition's blaze  Takes heed of those ordained to die. Believe! The final horseman comes―  His mount as white as virgin snow; The darkness of the world succumbs  O'er His redemption long ago. Ride swiftly with our righteous King,  Adorned in linen, clean and white; Come praise His holy name and sing  And spurn the horsemen of the night!

dclm

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dclm-429555011

Goodbye to Cancer… “Metal Seed” Destroys Tumors in 10 Minutes British Daily Telegraph reported that British Scientists discovered what is described as the magnetic “metal seed” that can destroy brain tumors in only 10 minutes. This new invention uses “MRI scanners” to heat up cancer cells until they die. The British University College London has developed the new cure which involves injecting a tiny magnetic metal seed in the bloodstream, directing it to the site of cancer cells and destroying them in only ten minutes. Scientists use “MRI scanners” to heat up the metal seed which causes the cells to die in the tissues. Not only does it kill cancer cells, but it saves healthy cells from the damaging effect of invasive surgery or radiotherapy. The team have experimented that technology on the brains of pigs and plans to move to human trials on patients with prostate cancer and other cancerous tumors. Mark Lythgoe, professor of imagining at UCL and member of  research team, said: “The simple idea is the patient goes into the MRI scanner, you locate a tumor in the brain or the prostate and then we implant a tiny magnetic particle, a little bit smaller than a grain of rice, to the site of the tumor,” he continued,” We can guide it with real precision avoiding any areas that we don’t want to go to, like the sensory motor-cortex in the brain, the area with memories and other areas.” Once it’s in there we’re able to fire in a simple radio wave and these seeds heat up well, and kills all the cancer cells and protect the healthy cells.” Source: Arabic.sputniknews Leave a Reply

dclm

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stackexchange-1842460

Pedigree Probability of Autosomal Recessive Trait Here is a pedigree: Pedigree Chart The trait is autosomal recessive. The question is: What is the probability that the bottom 2 people (4 and 5) have a child with the trait? I tried doing 2/3 * 2/3 * 2/3 *1/4 and got 2/27 but this is wrong. I thought that the probability of III 1 being a carrier is 2/3. The probability that IV 4 is a carrier is also 2/3. The probability that III 6 is a carrier is 2/3 and IV 5 must be a carrier. So IV 4 and IV 5 must be carriers. The probability that they have a child with the trait is 1/4. But I am not getting the right answer. The right answer is 1/6. Starting with the left hand side of the diagram: • III:2 is definitely a carrier (Tt) as one parent (II:2) is affected (tt). • III:1 is also definitely a carrier (Tt) as when mating with III:2 they produce an affected (tt) offspring (IV:1) • This means that we can work out the possibilities for IV:4 as we know the parent genotypes. It follows the standard arrangement for two carrier parents giving the options of: • TT (1/4) • Tt (2/4 = 1/2) • tt (Normally 1/4 but in this case 0 as individual not marked as affected). • Therefore for this scenario, the probabilities for IV:4 are : • TT (1/3) • Tt (2/3) Now if we look at the right hand side of the diagram. • IV:5 is definitely a carrier (Tt) as one of their parents (III:5) is affected. This gives two possible Punnett squares to be examined: |-------------------------------------------------------------------------------| | ♂ (IV:5) | | T t | | -------------------------------------------------------------------| | | | | | T | TT | Tt | | | | | | (IV:4) |-------------------------------------------------------------------| | ♀ | | | | T | TT | Tt | | | | | |-----------|-------------------------------------------------------------------| This gives nil affected offspring so we can disregard this option for your question (as we are ONLY looking for scenarios which produce affected individuals). Therefore the alternative is: |-------------------------------------------------------------------------------| | ♂ (IV:5) | | T t | | -------------------------------------------------------------------| | | | | | T | TT | Tt | | | | | | (IV:4) |-------------------------------------------------------------------| | ♀ | | | | t | TT | tt | | | | | |-----------|-------------------------------------------------------------------| Giving 1/4 affected offspring. As mentioned above, in order to have affected offspring then IV:4 must be Tt. There is a 2/3 chance of this being the case. If this is the case, then there is a 1/4 chance of the child being tt. Both conditions need to be true for this to happen so we multiply the fractions: 2/3 * 1/4 = 1/6

stackexchange

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pes2o-16766282

Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. BACKGROUND & AIMS Proprotein convertase 1/3 (PC1/3) deficiency, an autosomal-recessive disorder caused by rare mutations in the proprotein convertase subtilisin/kexin type 1 (PCSK1) gene, has been associated with obesity, severe malabsorptive diarrhea, and certain endocrine abnormalities. Common variants in PCSK1 also have been associated with obesity in heterozygotes in several population-based studies. PC1/3 is an endoprotease that processes many prohormones expressed in endocrine and neuronal cells. We investigated clinical and molecular features of PC1/3 deficiency. METHODS We studied the clinical features of 13 children with PC1/3 deficiency and performed sequence analysis of PCSK1. We measured enzymatic activity of recombinant PC1/3 proteins. RESULTS We identified a pattern of endocrinopathies that develop in an age-dependent manner. Eight of the mutations had severe biochemical consequences in vitro. Neonates had severe malabsorptive diarrhea and failure to thrive, required prolonged parenteral nutrition support, and had high mortality. Additional endocrine abnormalities developed as the disease progressed, including diabetes insipidus, growth hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism. We identified growth hormone deficiency, central diabetes insipidus, and male hypogonadism as new features of PCSK1 insufficiency. Interestingly, despite early growth abnormalities, moderate obesity, associated with severe polyphagia, generally appears. CONCLUSIONS In a study of 13 children with PC1/3 deficiency caused by disruption of PCSK1, failure of enteroendocrine cells to produce functional hormones resulted in generalized malabsorption. These findings indicate that PC1/3 is involved in the processing of one or more enteric hormones that are required for nutrient absorption.

pes2o

{"added":"2018-04-03T00:34:38.570Z","created":"2013-07-01T00:00:00.000Z","id":"77575","metadata":{"abstract":"BACKGROUND & AIMS\nProprotein convertase 1\/3 (PC1\/3) deficiency, an autosomal-recessive disorder caused by rare mutations in the proprotein convertase subtilisin\/kexin type 1 (PCSK1) gene, has been associated with obesity, severe malabsorptive diarrhea, and certain endocrine abnormalities. Common variants in PCSK1 also have been associated with obesity in heterozygotes in several population-based studies. PC1\/3 is an endoprotease that processes many prohormones expressed in endocrine and neuronal cells. We investigated clinical and molecular features of PC1\/3 deficiency.\n\n\nMETHODS\nWe studied the\u00a0clinical features of 13 children with PC1\/3 deficiency and performed sequence analysis of PCSK1. We measured\u00a0enzymatic activity of recombinant PC1\/3 proteins.\n\n\nRESULTS\nWe identified a pattern of endocrinopathies that develop in an age-dependent manner. Eight of the mutations had severe biochemical consequences in\u00a0vitro. Neonates had severe malabsorptive diarrhea and failure to thrive, required prolonged parenteral nutrition support, and had high mortality. Additional endocrine abnormalities developed as the disease progressed, including diabetes insipidus, growth hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism. We identified growth hormone deficiency, central diabetes insipidus, and male hypogonadism as new features of PCSK1 insufficiency. Interestingly, despite early growth abnormalities, moderate obesity, associated with severe polyphagia, generally appears.\n\n\nCONCLUSIONS\nIn a study of 13 children with PC1\/3 deficiency caused by disruption of PCSK1, failure of enteroendocrine cells to produce functional hormones resulted in generalized malabsorption. These findings indicate that PC1\/3 is\u00a0involved in the processing of one or more enteric hormones that are required for nutrient absorption.","abstract_count":241,"abstract_language":"en","abstract_perplexity":-17.323995729933348,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0004.json.gz:1279675","s2fieldsofstudy":["Medicine","Biology"],"sha1":"b91411298750e05844109cc739432f86f009bb79","sources":["Medline","ScienceParseMerged","Unpaywall","MAG"],"title":"Congenital proprotein convertase 1\/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort.","title_count":15,"title_language":"en","title_perplexity":-19.89269425555356,"top_frequencies":[{"count":11,"token":"of"},{"count":10,"token":"in"},{"count":9,"token":"and"},{"count":6,"token":"PC1\/3"},{"count":5,"token":"the"},{"count":5,"token":"with"},{"count":5,"token":"We"},{"count":4,"token":"severe"},{"count":4,"token":"that"},{"count":3,"token":"convertase"},{"count":3,"token":"deficiency"},{"count":3,"token":"malabsorptive"},{"count":3,"token":"a"},{"count":3,"token":"deficiency,"},{"count":3,"token":"an"},{"count":3,"token":"associated"},{"count":3,"token":"endocrine"},{"count":3,"token":"features"},{"count":3,"token":"had"},{"count":3,"token":"growth"},{"count":2,"token":"proprotein"},{"count":2,"token":"1\/3"},{"count":2,"token":"diarrhea"},{"count":2,"token":"endocrinopathies"},{"count":2,"token":"caused"},{"count":2,"token":"by"},{"count":2,"token":"mutations"},{"count":2,"token":"been"},{"count":2,"token":"obesity,"},{"count":2,"token":"PCSK1"},{"count":2,"token":"is"},{"count":2,"token":"clinical"},{"count":2,"token":"13"},{"count":2,"token":"children"},{"count":2,"token":"identified"},{"count":2,"token":"failure"},{"count":2,"token":"to"},{"count":2,"token":"required"},{"count":2,"token":"as"},{"count":2,"token":"diabetes"},{"count":2,"token":"insipidus,"},{"count":2,"token":"hormone"},{"count":2,"token":"hormones"},{"count":1,"token":"Congenital"},{"count":1,"token":"causes"},{"count":1,"token":"other"},{"count":1,"token":"pediatric"},{"count":1,"token":"cohort."},{"count":1,"token":"BACKGROUND"},{"count":1,"token":"&"},{"count":1,"token":"AIMS"},{"count":1,"token":"Proprotein"},{"count":1,"token":"(PC1\/3)"},{"count":1,"token":"autosomal-recessive"},{"count":1,"token":"disorder"},{"count":1,"token":"rare"},{"count":1,"token":"subtilisin\/kexin"},{"count":1,"token":"type"},{"count":1,"token":"1"},{"count":1,"token":"(PCSK1)"},{"count":1,"token":"gene,"},{"count":1,"token":"has"},{"count":1,"token":"diarrhea,"},{"count":1,"token":"certain"},{"count":1,"token":"abnormalities."},{"count":1,"token":"Common"},{"count":1,"token":"variants"},{"count":1,"token":"also"},{"count":1,"token":"have"},{"count":1,"token":"obesity"},{"count":1,"token":"heterozygotes"},{"count":1,"token":"several"},{"count":1,"token":"population-based"},{"count":1,"token":"studies."},{"count":1,"token":"endoprotease"},{"count":1,"token":"processes"},{"count":1,"token":"many"},{"count":1,"token":"prohormones"},{"count":1,"token":"expressed"},{"count":1,"token":"neuronal"},{"count":1,"token":"cells."},{"count":1,"token":"investigated"},{"count":1,"token":"molecular"},{"count":1,"token":"deficiency."},{"count":1,"token":"METHODS"},{"count":1,"token":"studied"},{"count":1,"token":"performed"},{"count":1,"token":"sequence"},{"count":1,"token":"analysis"},{"count":1,"token":"PCSK1."},{"count":1,"token":"measured"},{"count":1,"token":"enzymatic"},{"count":1,"token":"activity"},{"count":1,"token":"recombinant"},{"count":1,"token":"proteins."},{"count":1,"token":"RESULTS"},{"count":1,"token":"pattern"},{"count":1,"token":"develop"},{"count":1,"token":"age-dependent"},{"count":1,"token":"manner."}],"year":2013},"source":"s2","version":"v3-fos"}

dclm-430309441

Some Wheaton police had an unusual request the other day.  WBBM780 - Deputy Chief of the Wheaton Police Department PJ Youker said calls came in around 10 a.m. Sunday for a "roadway hazard" near the intersection of Naperville and Butterfield roads. The hazard? About 60 donuts in the middle of an intersection. Probably not a "hazard" exactly but probably better to get cleaned up rather than get smeared around the road. The police, while laughing about it, reminded people that it's always a good idea to alert authorities when they see something hazardous on the roads.

dclm

{"fasttext_score":0.045917809009552,"id":"<urn:uuid:a4eae80c-1b34-4a15-a05e-b87c8ab4b509>","language":"en","language_score":0.9566765427589417,"url":"https:\/\/q985online.com\/illinois-police-had-to-be-called-to-shovel-up-a-pile-of-donuts\/","nemo_id":"dclm-gs7-078335297"}

pes2o-11287414

Demand Shifts, Population Adjustments, and Labor Market Outcomes during the 1980s In this article we explore the effects of labor demand shifts and population adjustments across metropolitan areas on the employment and earnings of various demographic groups during the 1980s. We find that population shifts across areas at least partially offset the effects of these demand shifts, but less‐educated workers showed substantially lower population adjustments in response to these demand shifts. These limited supply responses apparently contributed importantly to relatively greater deterioration of employment and earnings of these groups in declining areas during the 1980s.

pes2o

{"added":"2019-05-16T13:04:39.511Z","created":"1996-07-01T00:00:00.000Z","id":"154342003","metadata":{"abstract":"In this article we explore the effects of labor demand shifts and population adjustments across metropolitan areas on the employment and earnings of various demographic groups during the 1980s. We find that population shifts across areas at least partially offset the effects of these demand shifts, but less\u2010educated workers showed substantially lower population adjustments in response to these demand shifts. These limited supply responses apparently contributed importantly to relatively greater deterioration of employment and earnings of these groups in declining areas during the 1980s.","abstract_count":84,"abstract_language":"en","abstract_perplexity":-12.943304134830528,"extfieldsofstudy":["Economics"],"provenance":"pes2o_v2-0002.json.gz:3548213","s2fieldsofstudy":["Economics"],"sha1":"1fdfa3eef39941b7b45fb44ec245bb96de1d0ad6","sources":["UChicago","Anansi","MergedPDFExtraction","MAG","ElsevierPush","Unpaywall"],"title":"Demand Shifts, Population Adjustments, and Labor Market Outcomes during the 1980s","title_count":11,"title_language":"en","title_perplexity":-16.362352018423476,"top_frequencies":[{"count":6,"token":"the"},{"count":5,"token":"of"},{"count":4,"token":"and"},{"count":3,"token":"during"},{"count":3,"token":"demand"},{"count":3,"token":"population"},{"count":3,"token":"areas"},{"count":3,"token":"these"},{"count":2,"token":"effects"},{"count":2,"token":"shifts"},{"count":2,"token":"adjustments"},{"count":2,"token":"across"},{"count":2,"token":"employment"},{"count":2,"token":"earnings"},{"count":2,"token":"groups"},{"count":2,"token":"1980s."},{"count":2,"token":"in"},{"count":2,"token":"to"},{"count":1,"token":"Demand"},{"count":1,"token":"Shifts,"},{"count":1,"token":"Population"},{"count":1,"token":"Adjustments,"},{"count":1,"token":"Labor"},{"count":1,"token":"Market"},{"count":1,"token":"Outcomes"},{"count":1,"token":"1980s"},{"count":1,"token":"In"},{"count":1,"token":"this"},{"count":1,"token":"article"},{"count":1,"token":"we"},{"count":1,"token":"explore"},{"count":1,"token":"labor"},{"count":1,"token":"metropolitan"},{"count":1,"token":"on"},{"count":1,"token":"various"},{"count":1,"token":"demographic"},{"count":1,"token":"We"},{"count":1,"token":"find"},{"count":1,"token":"that"},{"count":1,"token":"at"},{"count":1,"token":"least"},{"count":1,"token":"partially"},{"count":1,"token":"offset"},{"count":1,"token":"shifts,"},{"count":1,"token":"but"},{"count":1,"token":"less\u2010educated"},{"count":1,"token":"workers"},{"count":1,"token":"showed"},{"count":1,"token":"substantially"},{"count":1,"token":"lower"},{"count":1,"token":"response"},{"count":1,"token":"shifts."},{"count":1,"token":"These"},{"count":1,"token":"limited"},{"count":1,"token":"supply"},{"count":1,"token":"responses"},{"count":1,"token":"apparently"},{"count":1,"token":"contributed"},{"count":1,"token":"importantly"},{"count":1,"token":"relatively"},{"count":1,"token":"greater"},{"count":1,"token":"deterioration"},{"count":1,"token":"declining"}],"year":2000},"source":"s2","version":"v3-fos"}

pes2o-15782537

Effect on Health Care Expenditures During Nationwide Implementation of the Diabetes Prevention Program as a Health Insurance Benefit OBJECTIVE Lifestyle interventions slow development of type 2 diabetes by half, but the impact of health payer reimbursement for delivery of intervention programs is not well known. We evaluated net commercial health payer expenditures when offering reimbursement for access to YMCA’s Diabetes Prevention Program (YDPP) in 42 states. RESEARCH DESIGN AND METHODS We used a nonequivalent comparison group design to evaluate net health care expenditures for adults with prediabetes who attended one or more YDPP visit between 1 July 2009 and 31 May 2013 (“YDPP users”). Rolling, 1:1 nearest neighbor propensity score (PS) matching was used to identify a comparison group of nonusers. Administrative data provided measures of YDPP attendance, body weight at YDPP visits, and health care expenditures. Random effects, difference-in-difference regression was used to estimate quarterly health care expenditures before and after participants’ first visit to YDPP. RESULTS Worksite screening identified 9.7% of the target population; 39.1% of those identified (19,933 participants through June 2015) became YDPP users. Mean weight loss for YDPP users enrolled before June 2013 (n = 1,725) was 7.5 lb (3.4%); 29% achieved ≥5% weight loss. Inclusive of added costs to offer YDPP, there were no statistically significant differences in mean per-person net health care expenditures between YDPP users and PS-matched nonusers over 2 years ($0.2 lower [95% CI $56 lower to $56 higher]). Mean reimbursement to the YMCA was $212 per YDPP user, with 92.8% of all expenditures made for those who attended at a high rate (≥9 completed YDPP visits). CONCLUSIONS Worksite screening was inefficient for identifying the population with prediabetes, but those identified achieved modest YDPP attendance and clinically meaningful weight loss. Over 2 years, added costs to offer the intervention were modest, with neutral effects on net health care costs.

pes2o

{"added":"2019-04-24T13:03:27.018Z","created":"2019-04-22T00:00:00.000Z","id":"128362955","metadata":{"abstract":"OBJECTIVE Lifestyle interventions slow development of type 2 diabetes by half, but the impact of health payer reimbursement for delivery of intervention programs is not well known. We evaluated net commercial health payer expenditures when offering reimbursement for access to YMCA\u2019s Diabetes Prevention Program (YDPP) in 42 states. RESEARCH DESIGN AND METHODS We used a nonequivalent comparison group design to evaluate net health care expenditures for adults with prediabetes who attended one or more YDPP visit between 1 July 2009 and 31 May 2013 (\u201cYDPP users\u201d). Rolling, 1:1 nearest neighbor propensity score (PS) matching was used to identify a comparison group of nonusers. Administrative data provided measures of YDPP attendance, body weight at YDPP visits, and health care expenditures. Random effects, difference-in-difference regression was used to estimate quarterly health care expenditures before and after participants\u2019 first visit to YDPP. RESULTS Worksite screening identified 9.7% of the target population; 39.1% of those identified (19,933 participants through June 2015) became YDPP users. Mean weight loss for YDPP users enrolled before June 2013 (n = 1,725) was 7.5 lb (3.4%); 29% achieved \u22655% weight loss. Inclusive of added costs to offer YDPP, there were no statistically significant differences in mean per-person net health care expenditures between YDPP users and PS-matched nonusers over 2 years ($0.2 lower [95% CI $56 lower to $56 higher]). Mean reimbursement to the YMCA was $212 per YDPP user, with 92.8% of all expenditures made for those who attended at a high rate (\u22659 completed YDPP visits). CONCLUSIONS Worksite screening was inefficient for identifying the population with prediabetes, but those identified achieved modest YDPP attendance and clinically meaningful weight loss. Over 2 years, added costs to offer the intervention were modest, with neutral effects on net health care costs.","abstract_count":290,"abstract_language":"en","abstract_perplexity":-17.109055942305805,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0004.json.gz:295930","s2fieldsofstudy":["Medicine","Political Science"],"sha1":"bb2918379b9f3071b8d51b0ecdf341acd3f21d4a","sources":["MergedPDFExtraction","Crossref","Medline","Anansi","MAG","Highwire","Unpaywall"],"title":"Effect on Health Care Expenditures During Nationwide Implementation of the Diabetes Prevention Program as a Health Insurance Benefit","title_count":18,"title_language":"en","title_perplexity":-10.99449030986659,"top_frequencies":[{"count":10,"token":"of"},{"count":9,"token":"to"},{"count":9,"token":"YDPP"},{"count":7,"token":"health"},{"count":6,"token":"the"},{"count":6,"token":"for"},{"count":5,"token":"expenditures"},{"count":5,"token":"care"},{"count":5,"token":"and"},{"count":5,"token":"was"},{"count":4,"token":"a"},{"count":4,"token":"net"},{"count":4,"token":"with"},{"count":4,"token":"weight"},{"count":3,"token":"2"},{"count":3,"token":"reimbursement"},{"count":3,"token":"used"},{"count":3,"token":"identified"},{"count":3,"token":"those"},{"count":2,"token":"on"},{"count":2,"token":"Health"},{"count":2,"token":"Diabetes"},{"count":2,"token":"Prevention"},{"count":2,"token":"Program"},{"count":2,"token":"but"},{"count":2,"token":"payer"},{"count":2,"token":"intervention"},{"count":2,"token":"We"},{"count":2,"token":"in"},{"count":2,"token":"comparison"},{"count":2,"token":"group"},{"count":2,"token":"who"},{"count":2,"token":"attended"},{"count":2,"token":"visit"},{"count":2,"token":"between"},{"count":2,"token":"2013"},{"count":2,"token":"at"},{"count":2,"token":"before"},{"count":2,"token":"Worksite"},{"count":2,"token":"screening"},{"count":2,"token":"June"},{"count":2,"token":"Mean"},{"count":2,"token":"users"},{"count":2,"token":"achieved"},{"count":2,"token":"loss."},{"count":2,"token":"added"},{"count":2,"token":"costs"},{"count":2,"token":"offer"},{"count":2,"token":"were"},{"count":2,"token":"lower"},{"count":2,"token":"$56"},{"count":1,"token":"Effect"},{"count":1,"token":"Care"},{"count":1,"token":"Expenditures"},{"count":1,"token":"During"},{"count":1,"token":"Nationwide"},{"count":1,"token":"Implementation"},{"count":1,"token":"as"},{"count":1,"token":"Insurance"},{"count":1,"token":"Benefit"},{"count":1,"token":"OBJECTIVE"},{"count":1,"token":"Lifestyle"},{"count":1,"token":"interventions"},{"count":1,"token":"slow"},{"count":1,"token":"development"},{"count":1,"token":"type"},{"count":1,"token":"diabetes"},{"count":1,"token":"by"},{"count":1,"token":"half,"},{"count":1,"token":"impact"},{"count":1,"token":"delivery"},{"count":1,"token":"programs"},{"count":1,"token":"is"},{"count":1,"token":"not"},{"count":1,"token":"well"},{"count":1,"token":"known."},{"count":1,"token":"evaluated"},{"count":1,"token":"commercial"},{"count":1,"token":"when"},{"count":1,"token":"offering"},{"count":1,"token":"access"},{"count":1,"token":"YMCA\u2019s"},{"count":1,"token":"(YDPP)"},{"count":1,"token":"42"},{"count":1,"token":"states."},{"count":1,"token":"RESEARCH"},{"count":1,"token":"DESIGN"},{"count":1,"token":"AND"},{"count":1,"token":"METHODS"},{"count":1,"token":"nonequivalent"},{"count":1,"token":"design"},{"count":1,"token":"evaluate"},{"count":1,"token":"adults"},{"count":1,"token":"prediabetes"},{"count":1,"token":"one"},{"count":1,"token":"or"},{"count":1,"token":"more"},{"count":1,"token":"1"},{"count":1,"token":"July"},{"count":1,"token":"2009"}],"year":2019},"source":"s2","version":"v3-fos"}

flan-16876422

Translate to French: The production shall be deemed to conform to this Regulation if the following relationship between the speed indicated on the display of the speedometer (V1) and the actual speed (V2) is observed: Answer: La production sera considérée comme conforme au présent Règlement si la relation suivante est vérifiée entre la vitesse affichée par l'indicateur de vitesse (V1) et la vitesse réelle (V2) : IN: French: A doctor with the Medical Department of the Armed Forces advised Mr. Galbraith that he was unfit because of his ileostomy. OUT: Un médecin du Service de santé des Forces armées a avisé M. Galbraith qu’il était inapte en raison de son iléostomie. question: Divergent views were expressed with regard to the inclusion of the supplementary item in the agenda. --> French. answer: Des vues divergentes ont été exprimées concernant l'inclusion de la question supplémentaire à l'ordre du jour. Some text: Accélérer et accroître les investissements sans précédent dans l'infrastructure, en accordant près de 12 milliards de dollars de nouveau financement sur deux ans pour la construction et la réparation de routes, de ponts et de ports pour petits bateaux, le développement du service à large bande et des dossiers de santé électroniques ainsi que l'aménagement de laboratoires et de postes frontaliers d'un bout à l'autre du pays. Translate to English. Translation: Accelerating and expanding recent historic investments in infrastructure with almost $12 billion in new infrastructure funding over two years for the construction and repair of roads, bridges, small craft harbours, broadband internet access, electronic health records, laboratories and border crossings across the country. Q: Pour assurer la viabilité de la production agricole et réaliser le programme d'amélioration en la matière, y compris en ce qui concerne la stratégie d'utilisation des sols et de développement agraire, il est nécessaire de poser des fondements institutionnels et juridiques, outre les mesures institutionnelles qu'il faut prendre pour stimuler un tel développement. Could you please translate this to English? A: For sustainability of agricultural production and realization of the agricultural production improvement programme, including use of land and agrarian development strategy, the institutional-legal foundations need to be laid down, in addition to a series of institutional measures to stimulate such development. Translate to French: Karst.). According to the hypothesis, (i) within-population variation exists in the higher threshold for the rest-breaking temperature range and (ii) the higher threshold shifts towards lower temperatures as a result of chilling. Answer: Selon notre hypothèse, (i) il existe une variation intra-population quant à la limite supérieure de l'étendue des températures capables de lever la dormance et (ii) la limite supérieure se déplace vers des températures plus basses à la suite de l'exposition à des températures fraîches.

flan

{"attributes":{"dedupe_ngrams_8_1_all_train":[[21.0,218.0,0.0],[219.0,417.0,0.0],[430.0,553.0,0.0],[553.0,676.0,0.0],[676.0,799.0,0.0],[799.0,918.0,0.0],[918.0,1357.0,0.0],[1380.0,1716.0,0.0],[1716.0,2084.0,0.0],[2085.0,2129.0,0.0],[2129.0,2444.0,0.0],[2465.0,2695.0,0.0],[2696.0,2991.0,0.0]],"paloma_paragraphs":[]},"id":"5cda6552fea6ab6897834580280e8264","metadata":{"_replicate":0,"_task_name":"wmt14_translate\/fr-en:1.0.0","_task_source":"Flan2021","_template_idx":6,"_template_type":"fs_opt","provenance":"60M-shots_all-upweight_1-dialog_false-sep_rulebased-train-0090.json.gz:53179"},"source":"flan_v2"}

dclm-411578853

So This Is Super Bowl Advertising! images.jpgI’ve never watched a Super Bowl and I never will watch a Super Bowl. There may not be a lot of certainties in life, but this is one of mine. What’s amazing is how suddenly easy it’s become to catch up with practically a lifetime of Super Bowl ads. Heavy.com has the banned ones. Adverlicio.us has the online ones. MSN, Yahoo! and AOL will share Sunday’s on-air spots, as will any number of Super Bowl advertisers who will host their broadcast spots on their Web sites after they air. The Web’s a great thing. How else could I keep my life spectator sports-free and still do the job? Related reading Camera lens Simple Share Buttons

dclm

{"fasttext_score":0.020388901233673096,"id":"<urn:uuid:c0f3f96d-57f8-4cb0-b276-4ca03d414876>","language":"en","language_score":0.9234930276870728,"url":"https:\/\/searchenginewatch.com\/sew\/news\/2059687\/so-this-is-super-bowl-advertising","nemo_id":"dclm-gs7-077433402"}

stackexchange-1078735

How to save a GNOME 3 session GNOME 2 allows one to either save the session automatically or manually (i.e. save the session as it looks right now). This is a nice feature because it restores the various desktop states between logins (and system restarts): • which apps were open • where (physically) on the desktop were they open • what specific window sizes were these apps set to Looking around, I can't find the feature in GNOME 3? Did I not look hard enough? Normally you would Alt-F2 to run gnome-session-properties, and select "Automatically remember running applications when logging out" under the Options tab. However, it is broken at the moment. There is a bug filed: https://bugzilla.gnome.org/show_bug.cgi?id=647359

stackexchange

{"added":"2011-05-25T02:01:39.380","attributes":{"dedupe_para_ngrams_13_1":[]},"created":"2011-05-24T22:22:16.267","id":"unix_stackexchange_com-13725-13728","metadata":{"answer_comment_count":5,"answer_content_license":"CC BY-SA 3.0","answer_id":13728,"answer_last_activity_date":"2011-05-25T02:01:39.380","answer_last_edit_date":"","answer_last_editor_user_id":0,"answer_owner_user_id":6761,"answer_score":12,"answer_view_count":0,"forum":"unix_stackexchange_com","provenance":"20241028_173636_00007_mgema_801de1a3-04f4-4b81-ad53-b67365b16b4b.zst:32929","question_comment_count":0,"question_content_license":"CC BY-SA 3.0","question_id":13725,"question_last_activity_date":"2020-10-26T16:48:26.060","question_last_edit_date":"","question_last_editor_user_id":0,"question_owner_user_id":688,"question_score":36,"question_view_count":44376},"source":"stackexchange","version":"20240930"}

pes2o-18357837

Compliance with ivory trade regulations in the United Kingdom among traders Global demand for elephant ivory is contributing to illegal poaching and significant decline of African elephant (Loxondonta africana) populations. To help mitigate decline, countries with legal domestic ivory markets were recommended by the Convention on International Trade in Endangered Species of Wild Fauna and Flora to close domestic markets for commercial trade. However, implementing stricter regulations on wildlife trade does not necessarily mean compliance with rules will follow. Using an online questionnaire, we examined the relationship between self‐reported compliance with ivory trade regulations among 115 ivory traders in the United Kingdom and 4 dimensions (control, deterrence, legitimacy, and social norms) hypothesized to influence compliance with conservation regulations. Although most traders supported regulations, a large number did not always check that they comply with them when trading objects containing ivory. The main factors influencing compliance with ivory trade regulations were traders’ ability to comply and their perceptions of the regulations and punishments to deter illegal trade. These findings demonstrate the utility of conservation criminology to improve wildlife trade regulations and identify opportunities to reduce illegal ivory entering the market in the United Kingdom. Compliance could be improved by clearer regulations that facilitate easier detection of illegal ivory products and stronger prosecution of violations.

pes2o

{"added":"2019-01-22T22:29:34.797Z","created":"2019-03-15T00:00:00.000Z","id":"58629576","metadata":{"abstract":"Global demand for elephant ivory is contributing to illegal poaching and significant decline of African elephant (Loxondonta africana) populations. To help mitigate decline, countries with legal domestic ivory markets were recommended by the Convention on International Trade in Endangered Species of Wild Fauna and Flora to close domestic markets for commercial trade. However, implementing stricter regulations on wildlife trade does not necessarily mean compliance with rules will follow. Using an online questionnaire, we examined the relationship between self\u2010reported compliance with ivory trade regulations among 115 ivory traders in the United Kingdom and 4 dimensions (control, deterrence, legitimacy, and social norms) hypothesized to influence compliance with conservation regulations. Although most traders supported regulations, a large number did not always check that they comply with them when trading objects containing ivory. The main factors influencing compliance with ivory trade regulations were traders\u2019 ability to comply and their perceptions of the regulations and punishments to deter illegal trade. These findings demonstrate the utility of conservation criminology to improve wildlife trade regulations and identify opportunities to reduce illegal ivory entering the market in the United Kingdom. Compliance could be improved by clearer regulations that facilitate easier detection of illegal ivory products and stronger prosecution of violations.","abstract_count":202,"abstract_language":"en","abstract_perplexity":-13.896905342515096,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0004.json.gz:2871230","s2fieldsofstudy":["Economics"],"sha1":"cdd99a1bc16e1eacbef59363b437cde11e8615aa","sources":["MergedPDFExtraction","MAG","Medline","Wiley","Unpaywall","Crossref"],"title":"Compliance with ivory trade regulations in the United Kingdom among traders","title_count":11,"title_language":"en","title_perplexity":-11.640866679014664,"top_frequencies":[{"count":8,"token":"ivory"},{"count":8,"token":"the"},{"count":8,"token":"and"},{"count":7,"token":"with"},{"count":7,"token":"regulations"},{"count":7,"token":"to"},{"count":6,"token":"of"},{"count":5,"token":"trade"},{"count":4,"token":"in"},{"count":4,"token":"illegal"},{"count":4,"token":"compliance"},{"count":3,"token":"United"},{"count":3,"token":"traders"},{"count":2,"token":"Compliance"},{"count":2,"token":"Kingdom"},{"count":2,"token":"among"},{"count":2,"token":"for"},{"count":2,"token":"elephant"},{"count":2,"token":"domestic"},{"count":2,"token":"markets"},{"count":2,"token":"were"},{"count":2,"token":"by"},{"count":2,"token":"on"},{"count":2,"token":"trade."},{"count":2,"token":"wildlife"},{"count":2,"token":"not"},{"count":2,"token":"conservation"},{"count":2,"token":"that"},{"count":2,"token":"comply"},{"count":1,"token":"Global"},{"count":1,"token":"demand"},{"count":1,"token":"is"},{"count":1,"token":"contributing"},{"count":1,"token":"poaching"},{"count":1,"token":"significant"},{"count":1,"token":"decline"},{"count":1,"token":"African"},{"count":1,"token":"(Loxondonta"},{"count":1,"token":"africana)"},{"count":1,"token":"populations."},{"count":1,"token":"To"},{"count":1,"token":"help"},{"count":1,"token":"mitigate"},{"count":1,"token":"decline,"},{"count":1,"token":"countries"},{"count":1,"token":"legal"},{"count":1,"token":"recommended"},{"count":1,"token":"Convention"},{"count":1,"token":"International"},{"count":1,"token":"Trade"},{"count":1,"token":"Endangered"},{"count":1,"token":"Species"},{"count":1,"token":"Wild"},{"count":1,"token":"Fauna"},{"count":1,"token":"Flora"},{"count":1,"token":"close"},{"count":1,"token":"commercial"},{"count":1,"token":"However,"},{"count":1,"token":"implementing"},{"count":1,"token":"stricter"},{"count":1,"token":"does"},{"count":1,"token":"necessarily"},{"count":1,"token":"mean"},{"count":1,"token":"rules"},{"count":1,"token":"will"},{"count":1,"token":"follow."},{"count":1,"token":"Using"},{"count":1,"token":"an"},{"count":1,"token":"online"},{"count":1,"token":"questionnaire,"},{"count":1,"token":"we"},{"count":1,"token":"examined"},{"count":1,"token":"relationship"},{"count":1,"token":"between"},{"count":1,"token":"self\u2010reported"},{"count":1,"token":"115"},{"count":1,"token":"4"},{"count":1,"token":"dimensions"},{"count":1,"token":"(control,"},{"count":1,"token":"deterrence,"},{"count":1,"token":"legitimacy,"},{"count":1,"token":"social"},{"count":1,"token":"norms)"},{"count":1,"token":"hypothesized"},{"count":1,"token":"influence"},{"count":1,"token":"regulations."},{"count":1,"token":"Although"},{"count":1,"token":"most"},{"count":1,"token":"supported"},{"count":1,"token":"regulations,"},{"count":1,"token":"a"},{"count":1,"token":"large"},{"count":1,"token":"number"},{"count":1,"token":"did"},{"count":1,"token":"always"},{"count":1,"token":"check"},{"count":1,"token":"they"},{"count":1,"token":"them"},{"count":1,"token":"when"},{"count":1,"token":"trading"}],"year":2019},"source":"s2","version":"v3-fos"}

pes2o-30730699

Regulation of the transforming growth factor β pathway by reversible ubiquitylation The transforming growth factor β (TGFβ) signalling pathway plays a central role during embryonic development and in adult tissue homeostasis. It regulates gene transcription through a signalling cascade from cell surface receptors to intracellular SMAD transcription factors and their nuclear cofactors. The extent, duration and potency of signalling in response to TGFβ cytokines are intricately regulated by complex biochemical processes. The corruption of these regulatory processes results in aberrant TGFβ signalling and leads to numerous human diseases, including cancer. Reversible ubiquitylation of pathway components is a key regulatory process that plays a critical role in ensuring a balanced response to TGFβ signals. Many studies have investigated the mechanisms by which various E3 ubiquitin ligases regulate the turnover and activity of TGFβ pathway components by ubiquitylation. Moreover, recent studies have shed new light into their regulation by deubiquitylating enzymes. In this report, we provide an overview of current understanding of the regulation of TGFβ signalling by E3 ubiquitin ligases and deubiquitylases. Summary The transforming growth factor b (TGFb) signalling pathway plays a central role during embryonic development and in adult tissue homeostasis. It regulates gene transcription through a signalling cascade from cell surface receptors to intracellular SMAD transcription factors and their nuclear cofactors. The extent, duration and potency of signalling in response to TGFb cytokines are intricately regulated by complex biochemical processes. The corruption of these regulatory processes results in aberrant TGFb signalling and leads to numerous human diseases, including cancer. Reversible ubiquitylation of pathway components is a key regulatory process that plays a critical role in ensuring a balanced response to TGFb signals. Many studies have investigated the mechanisms by which various E3 ubiquitin ligases regulate the turnover and activity of TGFb pathway components by ubiquitylation. Moreover, recent studies have shed new light into their regulation by deubiquitylating enzymes. In this report, we provide an overview of current understanding of the regulation of TGFb signalling by E3 ubiquitin ligases and deubiquitylases. The transforming growth factor b signalling pathway The transforming growth factor b (TGFb) family of cytokines control a plethora of cellular processes, including proliferation, differentiation, extra-cellular matrix production, motility and survival [1,2]. These translate into critical tissue functions throughout embryogenesis and adult life, achieved by striking a balance between proliferation and differentiation [2 -4]. When this balance is perturbed, the TGFb pathway malfunctions. Aberrant TGFb signalling is associated with many human diseases including immune disorders, fibrosis, cancer progression and metastasis [5][6][7][8][9][10][11][12]. Therefore, understanding the molecular mechanisms underpinning the regulation of the TGFb pathway would facilitate novel therapeutic opportunities against these diseases. TGFb signalling is initiated when ligands bind to their cognate receptors (figure 1). There are at least 42 different TGFb ligands, which are divided into two main subgroups: the TGFb family and the bone morphogenetic protein (BMP) family. Ligand binding induces specific quaternary complex formation of the transmembrane serine threonine kinase receptors. These receptors are divided into type I (ALK1-7) and type II (ACVR-IIA, ACVR-IIB, BMPR-II, AMHR-II and TGFbR-II). SMAD proteins are the intracellular transducers of the pathway; they are divided into specific subgroups: receptor-regulated (R-SMADs; 1-3, 5 and 8), the co-SMAD (4) and the inhibitory (I-) SMADs (6 and 7). Upon ligand binding, the type II receptors phosphorylate and activate the type I receptors. Activated type I receptors phosphorylate the R-SMADs at their C-terminal SXS motif. This induces R-SMAD complex formation with SMAD4 and nuclear translocation, where along with their nuclear cofactors & 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. they bind DNA and regulate transcription. The vast number of ligands and receptors allows for the formation of unique ligand-receptor complexes in distinct biological settings. In general, the TGFb receptor subfamily signals through SMADs 2 and 3, while the BMP subfamily signals through SMADs 1, 5 and 8, although some crosstalk between the two pathways has been reported. A negative feedback loop is created by TGFb-or BMP-induced transcription of the I-SMADs. I-SMADs inhibit the pathway by competing with R-SMADs for association with the type I receptors, or by recruiting E3 ubiquitin ligases and targeting the receptors for degradation. In the nucleus, a variety of nuclear cofactors are required for the R-SMADs to bind DNA and induce gene transcription (figure 1). Additionally, various histone and DNA modifiers are required for opening or closing sections of DNA to transcriptional regulation by R-SMADs [1,[13][14][15][16][17][18]. While we focus on the role of reversible ubiquitylation in regulating the core components of the TGFb pathway in this review, they can be further regulated by multiple post-translational modifications, which also impact the outcome of TGFb signalling. Often it is the integration of all the regulatory inputs that determines the cellular responses to TGFb signals. Reversible ubiquitylation Ubiquitylation, also referred to as ubiquitination, is a reversible process by which ubiquitins are attached to proteins, either singly or in chains. This post-translational modification causes target proteins to undergo changes in stability, subcellular localization or activity. Ubiquitin is a member of a conserved family of small eukaryotic proteins (approx. 8.5 kDa) that share the ubiquitin fold structure. Through an isopeptide bond, ubiquitin is attached to lysine residues on the target, creating mono-ubiquitylated proteins. Attaching more ubiquitin molecules to the lysines of an already proteinbound ubiquitin creates polyubiquitin chains. Depending on which lysine the subsequent ubiquitin molecules are attached to, different fates await the polyubiquitylated proteins. While eight linkage types are possible (through K6, K11, K27, K29, K33, K48, K63 and a-amino group of ubiquitin) as well as mixed chains, not all have been attributed a function. Two linkage types are commonly studied and reported in the TGFb pathway: K48 chains are known to signal protein degradation, while K63 chains play a role in signalling as well as in protein trafficking and endocytosis. Ubiquitin attachment is achieved through a three-step process catalysed by an E1-ubiquitin-activating enzyme, specific E2-ubiquitin-conjugating enzymes and a wide array of E3-ubiquitin ligases. E1 enzymes activate and transfer ubiquitin in an ATP-dependant manner to the E2-ubiquitinconjugating enzyme. This high-energy ubiquitin-E2 conjugate then specifically interacts with the E3-ubiquitin ligase, which could be either a single protein or part of a larger ligase complex. E3s can be divided into three structural groups, U-Box, HECT and Ring E3s, depending on their conserved domains and mode of catalysis. Several ubiquitin-like proteins (UBLs), including SUMO1-3, NEDD8, FUBI, HUB1, ISG15, FAT10, URM1, UFM1, Atg12 and Atg8, share a similar three-step attachment process. However, these UBLs use rsob.royalsocietypublishing.org Open Biol 2: 120082 different E1, E2 and E3 enzymes. While SUMO (small ubiquitinlike modifier) has been reported to modulate TGFb signalling, this review will concentrate on ubiquitin [19][20][21][22][23][24]. The removal of ubiquitins or polyubiquitin chains from the target protein is catalysed by deubiquitylating enzymes (DUBs). Therefore, DUBs reverse the function of E3 ubiquitin ligases [25]. DUBs remove ubiquitin from cellular adducts, process inactive ubiquitin precursors, proofread ubiquitinprotein conjugates and protect the 26S proteasome from ubiquitin chain accumulation [26]. Furthermore, DUBs generate free ubiquitin by removing and chopping ubiquitin chains from proteins, leading to recycling of ubiquitin, thereby contributing to ubiquitin homeostasis. The fate of ubiquitylated proteins can be further modified by DUBs that edit or trim ubiquitin chains, resulting in a reversal of ubiquitin signalling. This could lead to protein stabilisation by rescue from degradation [25]. Deubiquitylation is implicated in several cellular functions such as gene expression, DNA repair, cell cycle regulation, kinase activation and microbial pathogenesis [27]. DUBs are classified into five distinct functional and structural groups: the zinc metalloproteases JAMM/MPNþ, and the cysteine proteases, comprised of ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), ovarian tumour proteases (OTUs) and Josephins [25]. There are also DUBs that resemble the adenovirus protease that cleave interferon-stimulated gene 15 (ISG15) conjugates and ubiquitin-like proteases (ULPs), which belong to the Adenain family of cysteine proteases, that are specific to ubiquitin-like proteins SUMO or NEDD8 [27]. As the human genome encodes less than 100 DUBs, it is evident that DUBs are highly regulated and play a role in diverse signalling pathways in order to oppose the action of over 600 E3 ligases [25,28]. A combination of substrate and target choice determines overall DUB specificity, which is further regulated by conformational/post-translational changes, subcellular localization and interactions with cofactors. DUBs distinguish between ubiquitin-like molecules, isopeptides, linear peptides and different types of ubiquitin linkage and chain structures as well as exo-versus endo-deubiquitylation to ensure specificity. Enzymatic activity of DUBs is often cryptic and regulated by occluding the substrate-binding site of certain DUBs or by inducing conformational changes that activate the catalytic site. Apart from these substrate-induced conformational changes and post-translational covalent modifications, activity can also be regulated by interacting cofactors. Other events, such as transcriptional regulation of DUB expression and subcellular localization, further ensure specific ubiquitin chain cleavage. DUBs are modular and contain multiple domains that mediate protein-protein interactions, apart from their catalytic domains. These domains include ubiquitin-binding domains (UBDs) or ubiquitin-like folds (UBL folds), ubiquitininteracting motifs (UIMs), zinc finger USP domains (ZnF-UBP domain) and ubiquitin-associated domains (UBA domains). These domains contribute to the binding and recognition of different ubiquitin chain linkages but some DUBs also display direct affinity for their ubiquitylated target protein [25,27,28]. Recent studies have demonstrated that DUBs play critical roles in the TGFb pathway regulation [7,29,30]. However, the field requires further research in order to identify DUBs that regulate the TGFb pathway and understand their mode of action. Understanding the precise roles of DUBs in regulating the TGFb pathway may unravel new opportunities for therapeutic intervention. Regulation of the TGF b pathway components by reversible ubiquitylation The fundamental steps and the key players in the TGFb pathway are generally well defined. In this review, we focus on our understanding of how reversible ubiquitylation impacts three groups of key TGFb pathway mediators: the TGFb receptors, the SMAD transcription factors and nuclear SMAD cofactors. By integrating multiple signals, reversible ubiquitylation of these components in different biological contexts plays crucial roles in balancing the outcome of TGFb signalling. Defective ubiquitylation of the TGFb pathway components has been implicated in many human diseases, especially cancer [7,8,11,12,31 -34]. Reversible ubiquitylation of TGF b receptors Receptor complex assembly and activation upon binding TGFb ligands are central to the activation of intracellular signalling. The activity and integrity of type II and type I TGFb receptors can be modulated by several strategies: dephosphorylation of the activated receptors, interfering with the receptor/R-SMAD binding, changing receptor localization and/or targeting receptors for proteasomal degradation. I-SMADs play a crucial role in some of these strategies by modulating the activity and stability of active TGFb receptor complexes. SMAD7 was reported to inhibit the TGFb pathway by not only interfering with R-SMAD phosphorylation but also recruiting the E3 ubiquitin ligases SMURF1 and SMURF2 to the receptor complex (figure 2) [35,36]. This led to both receptors (ALK5 and TGFbR-II) and SMAD7 being ubiquitylated and targeted for degradation. Similarly, SMAD6/7 has been described to direct SMURF1 to ALK6 and mediates receptor ubiquitylation and degradation [37]. Both I-SMADs and SMURF1/2 are transcriptional targets of TGFb and BMP signals, thereby creating a negative feedback loop [38,39]. A glycosyl phosphatidylinositol-anchored protein, CD109, further enhances the SMAD7-SMURF2 receptor complex interaction, strengthening the negative feedback [40,41]. Conversely, a recent study demonstrated that a protein named TGF-b-stimulated clone 22 (TSC-22), which is induced by TGFb, inhibits the SMAD7-SMURF complex from binding, ubiquitylating and degrading the receptor complex. As expected, this leads to enhanced TGFb signalling that translated physiologically into increased TGFb-induced cellular differentiation [42]. Tribbles homologue 3 (TRB3) is another TGFb-induced gene capable of enhancing pathway signalling in a positive feedback loop. TRB3 enhances SMAD3 nuclear localization and induces degradation of SMURF2 promoting cell migration, invasion and epithelial to mesenchymal transition (EMT) [43]. In human renal cell carcinomas, enhanced SMURF2 expression causes the reduction in levels of type II TGFb receptor by proteasomal degradation [8]. SMURF1 and SMURF2 belong to the NEDD4-like family of HECT E3 ubiquitin ligases and are characterized by the presence of a conserved C2-WW-HECT domain structure [44]. While the C2 domain regulates the subcellular localization, the WW domains are 38-40 residue rsob.royalsocietypublishing.org Open Biol 2: 120082 motifs characterized by two highly conserved tryptophans and folded as a three-strand b sheet that associate with the prolinerich 'PPXY' motif (also known as 'PY' motif) [45]. The PY motif present in the linker region of SMAD7 interacts with one of the WW domains of SMURF1/2 [35]. Other members of the NEDD4-like family, WWP1 and NEDD4L, have also been shown to interact with SMAD7 and target ALK5 for ubiquitylation and degradation. However, unlike SMURF1/2, they did not target SMAD7 itself for ubiquitin-mediated degradation, possibly providing a stronger and longer lasting negative regulation of the pathway [46][47][48]. In our studies, we have identified three further members of the NEDD4-like family of E3s, namely NEDD4, WWP2 and ITCH, as SMAD6/7 interactors. These are also likely to act in a similar mode to regulate the activity and stability of the TGFb receptors. The precise nature of ubiquitin attachment and the sites for ubiquitylation on TGFb receptors remain undefined. While several E3s have been implicated to act on the TGFb receptors, to date very few E2-ubiquitin-conjugating enzymes have been assigned. SMAD7 has been reported to facilitate the recruitment of UbcH7, an E2 enzyme, to SMURF2 thereby providing a pathway-specific control on SMURF2 activity [49]. The regulation of TGFb receptors by DUBs would be predicted to reverse the effects of E3 ubiquitin ligases and positively regulate the TGFb pathway. To date, only two studies have addressed deubiquitylation of the receptors. UCH37 was reported to target ALK5 for deubiquitylation thereby enhancing TGFb signalling [50]. However, structural studies on the UCH family of DUBs imply they are di-or polyubiquitin chain editors [25]. USP15 was identified as a modulator of TGFb-induced transcription from a pan DUB-siRNA screen and subsequently shown to act on ALK5. The study further linked USP15 gene amplification with poor prognosis in glioblastoma [7]. Regulation of SMAD transcription factors by reversible ubiquitylation SMAD proteins are the intracellular transducers of TGFb signals. R-SMADs are phosphorylated at their C-terminal SXS motif inducing complex formation with SMAD4 and nuclear translocation. In the nucleus, they induce transcriptional responses of TGFb target genes. Interfering with R-SMAD phosphorylation, stability, R-SMAD/SMAD4 complex formation or DNA binding would negatively impact TGFb pathway signalling. Reversible ubiquitylation of SMADs directly impacts one or more of these attributes. Here, we provide an overview of how reversible ubiquitylation of SMAD transcription factors impacts SMAD function and pathway signalling. Figure 3 summarizes the key players regulating reversible ubiquitylation of SMADs. The BMP pathway SMADS The first E3 ligase reported to ubiquitylate BMP-responsive SMADs was SMURF1 [51]. The WW domain of SMURF1 interacts with the PY motif of SMAD1/5 and targets them for ubiquitylation and proteasomal degradation [51,52]. Studies in Xenopus embryos showed that SMURF1 causes dorsalization of ventral mesoderm and neuralization of ectoderm, phenotypes consistent with inhibition of the BMP pathway [51]. SMURF1-mediated SMAD1/5 ubiquitylation promotes myogenic differentiation of C2C12 cells, blocks BMP-2-mediated osteogenic conversion [52] and modulates the effects of BMP4 on embryonic lung growth [53]. In contrast, SMURF1 has been shown to have little effect on TGFb-inhibited myogenic differentiation [51,52]. LMP-1, an LIM domain protein capable of inducing de novo bone formation that contains a WW domain, interacts with SMURF1 and competes with SMAD1/5 for binding . Consequently, LMP-1 prevents SMURF1-mediated SMAD1/5 ubiquitylation and results in increased cellular responsiveness to BMP signals [54]. The PY motif in SMAD1/5 is preceded by a cluster of Ser/Thr residues. Phosphorylation of these residues, catalysed by proline-directed Ser/Thr protein kinases (e.g. MAP kinases and CDK8/9), in response to different stimuli as well as glycogen synthase kinase-3 (GSK-3) is essential for its interaction with SMURF1 [55 -57]. BMP-induced sequential linker phosphorylation of SMAD1 by CDK8/9 and GSK-3 primes SMAD1 for transcriptional action and degradation, respectively. While phosphorylation by CDK8/9 induces recruitment of YAP1 mediator through its WW domain, subsequent phosphorylation by GSK-3 displaces YAP1 and recruits SMURF1 [45,55]. YAP1 stability is further regulated by SCF (Skp, Cullin, F-box)-bTRCP-induced ubiquitylation [58]. These studies demonstrate a clear interplay between phosphorylation and ubiquitylation in balancing the outcome of BMP pathway signalling. SMURF2 has also been shown to polyubiquitylate SMAD1 and mediates its degradation. Studies in Xenopus embryos confirmed that SMURF2 inhibits SMAD1 responses [59,60]. SMAD8 lacks the PY motif in its linker region and would be predicted to be resistant to SMURF-mediated ubiquitylation and degradation. A U-box-dependent E3 ubiquitin ligase member carboxyl terminus of Hsc70-interacting protein (CHIP) was reported as an interactor of SMAD1. CHIP was shown to cause ubiquitylation and degradation of SMAD1, resulting in the inhibition of the BMP-induced transcriptional activity [61]. The lysine residues within BMP-SMADs modified by ubiquitylation, the nature of polyubiquitin linkages and the E2-ubiquitin-conjugating enzymes involved remain to be defined. No DUBs for BMP-SMADs have been reported. The TGF b pathway SMADs Among the SMADs, TGFb-SMAD ubiquitylation has received the most scrutiny. The evidence for polyubiquitylation and degradation of TGFb-induced phospho-SMAD2 was first demonstrated in 1999 [62]. Subsequently, several E3 ubiquitin ligases, including SMURF1/2, NEDD4L and WWP1, have been implicated in mediating the polyubiquitylation and degradation of SMAD2/3 [47,48,59,63]. These NEDD4like E3 ubiquitin ligase members all use the PY motif present in the SMAD2/3-linker for interaction. However, the recruitment of NEDD4L to SMAD2/3 requires the phosphorylation of the linker region mediated by CDK8/9 as well as the PY motif [64]. A WW-domain-containing protein PIN1 has been implicated in recruiting SMURF2 to linker-phosphorylated SMADs [65]. NEDD4L itself is also subject to further regulation by serum/glucocorticoid-regulated kinase 1 (SGK1), which is itself a transcriptional target of TGFb signalling [64]. Signal termination is also achieved by other E3 ligases, independent of linker phosphorylation, using SMAD2/3 interactions with transcriptional cofactors. The ROC1-SCF-bTRCP RING E3 ligase complex targets activated SMAD3 for nuclear export and ubiquitin-mediated degradation upon its association with the transcriptional co-activator p300 [66] . The transcriptional regulator TAZ, reported to be required for SMAD2/3/ 4 complex nuclear accumulation, is also regulated by SCF-bTRCP-induced ubiquitylation and degradation [67,68]. While the previous examples show SMAD2/3 regulation after TGFb signal initiation, CHIP has been shown to interact with ubiquitylate and degrade basal SMAD3 levels, resulting in the inhibition of TGFb signalling [69]. SMURF2 features prominently in reports describing SMAD2/3 degradation. SMURF2-mediated inhibition of TGFb signalling has been demonstrated across multiple organisms and in obstructive nephropathy [34,39,65,70]. One area of contention is whether SMURF2 polyubiquitylates [39,65,70] or monoubiquitylates [34] the TGFb SMADs, targeting them for degradation or inhibiting complex formation with SMAD4, respectively. Nonetheless, both outcomes are reported to result in TGFb signalling inhibition. A member of the RING E3 ubiquitin ligase family, ARKA-DIA, was initially reported to ubiquitylate phosphorylated SMAD2/3 in the nucleus [71]. Despite this, ARKADIA resulted in enhanced TGFb signalling. While counterintuitive, this was consistent with previous reports showing the effect of ARKADIA on Nodal signalling [72,73]. It was later shown that ARKADIA targets the inactive phospho-SMAD2/3-SKI complex for ubiquitylation and degradation rsob.royalsocietypublishing.org Open Biol 2: 120082 [74]. SKI is a nuclear cofactor that negatively regulates TGFb signalling by binding phosphorylated SMADs and preventing their transcriptional activity. ARKADIA balances SKI and SMAD2/3 ubiquitin-mediated degradation enhancing pathway transcriptional responses while terminating signalling once that is achieved. Changing the balance leads to TGFb-pathway-related pathology in colorectal cancer where mutations leading to a reduction in ARKADIA function have been reported [11]. WWP1/2 have also been implicated in ubiquitylation and destabilization of SMAD2/3 [48,75]. While ITCH and CBLB E3 ubiquitin ligases have been reported to ubiquitylate SMAD2, they promote TGFb-induced SMAD2 phosphorylation and signalling [76][77][78] . Although ITCH mediates the attachment of K48-linked ubiquitin chains on SMAD2, no degradation is observed [77]. This indicates that certain K48-linked polyubiquitin chains may have functions beyond proteasome-mediated degradation. Despite numerous E3 ubiquitin ligases proposed to ubiquitylate the TGFb SMADs, USP15 is the only deubiquitylase reported to act on SMAD2/3 [30]. USP15 has been reported to reverse SMAD2/3 monoubiquitylation, which targets the DNA-binding domains of SMAD2/3 and inhibits promoter recognition. The DUBs reversing the polyubiquitylation of SMAD2/3 remain to be defined. SMAD4 Association of SMAD4 with R-SMADs is a critical step in the canonical TGFb and BMP signalling pathways. Preventing this association or targeting SMAD4 for degradation inhibits TGFb/BMP signalling. Regulation of SMAD4 by both monoand polyubiquitylation has been reported [61,[79][80][81][82][83][84]. Despite the lack of an intact PY motif, SMAD4 is polyubiquitylated by SMURF1/2, WWP1 and NEDD4L, which are recruited to SMAD4 by their association with I-SMADs and SMAD2 [83]. The E3 ligase CHIP has been implicated in controlling SMAD4 stability; however its role in SMAD4 ubiquitylation is unclear [61]. SCF complexes have been reported to ubiquitylate and degrade SMAD4. b-TRCP1 was initially shown to bind SMAD4 and induce its ubiquitin-mediated degradation through SCF. In the absence of SMAD4, the over-expressed complex was unable to inhibit TGFb-induced cell cycle arrest [84]. SCF -bTRCP1 complex has been reported to control SMAD4 stability in pancreatic cancer cells [12]. The other SCF complex with SKP2 was also shown to bind and degrade SMAD4 [82]. Interestingly, TGFb induces destruction of SKP2 in the nucleus, providing a further layer of control in the feedback loop [81]. The RING E3 ubiquitin ligase TRIM33 (also known as Ectodermin/TIF1g), which also contains a plant homeodomain (PHD)-Bromo domain, has been proposed to interact with and ubiquitylate SMAD4 [80]. Although the critical role of TRIM33 on the TGFb pathway is not debated, reports on the mechanisms by which it achieves this differ greatly. Two modes of action have been proposed. (i) TRIM33 interacts with phosphorylated SMAD2/3 in competition with SMAD4, thereby interfering with SMAD2/3-SMAD4 binding and creating separate SMAD2/3-SMAD4 and SMAD2/3-TRIM33 complexes, each resulting in distinct functions on cellular processes [85,86]. Furthermore, the PHD-Bromo domain has been demonstrated to be essential for the recruitment of TRIM33 to chromatin [79,86]. (ii) TRIM33 directly interacts with SMAD4 and not SMAD2/3, catalyses its polyubiquitylation [80] or mono-ubiquitylation at Lys519, which inhibits SMAD2/3-SMAD4 complex formation [29]. It has been shown that chromatin binding is required for the E3 ligase activity of TRIM33 in vitro [79]. While targeted disruption of the TRIM33 gene in mice has established the role for TRIM33 in limiting Nodal responsiveness in vivo [87], it has not resolved the debate on its mode of action. A mouse or a cell-line model in which wild-type TRIM33 is replaced by a catalytically inactive mutant with an intact PHD-Bromo domain would resolve definitively the issue of whether the E3 ligase activity of TRIM33 on SMAD4 is necessary for its influence on the TGFb pathway. USP9X/FAM is the only deubiquitylase reported to reverse the monoubiquitylation of SMAD4 at Lys519 mediated by TRIM33 [29]. Depletion of USP9X resulted in inhibition of TGFb-induced transcriptional and cellular responses but not phospho-SMAD3. USP9X interacted with and deubiquitylated SMAD4 [29]. Inhibitory SMADs 6/7 In the light of multiple reports on the inhibitory effects of I-SMADs, inducing I-SMAD polyubiquitylation and degradation would be predicted to strongly enhance TGFb/BMP pathway signalling. Although SMAD6/7 interact with the majority of NEDD4-like E3 ubiquitin ligases through their PY motif, these E3s primarily employ SMAD7 as an adaptor to target various substrates, including the TGFb/BMP receptors. In the process, I-SMADs are often destroyed by proteasomal degradation [35,36]. ARKADIA, an E3 ligase that does not target the receptor complex, has been shown to target SMAD7 for ubiquitylation and degradation, thereby enhancing pathway signalling [88,89]. ARKADIA also targets multiple components of the TGFb pathway for ubiquitylation and degradation [11,65,71,74,[90][91][92][93]. However, selective SMAD7 polyubiquitylation and degradation has been reported in renal fibrosis and hypertension mouse models, causing enhanced pathway signalling [31,94]. Inhibition of I-SMAD ubiquitylation and subsequent degradation would provide a clear way to negatively control the TGFb pathway. The histone acetyl transferase, p300, has been reported to acetylate SMAD7 at Lys64 and Lys70, the same residues in which ubiquitylation occurs. This prevents SMAD7 from being targeted by E3s for ubiquitylation and degradation [95,96]. It has also been reported that the de-acetylase SIRT1 can reverse this, creating an acetylation/ de-acetylation balance controlling SMAD7 fate [97,98]. The only DUB reported to target the I-SMADs is CYLD [99]. The study performed in CYLD-knockout mice reported that CYLD targets SMAD7 protein for deubiquitylation and inhibits TGF-b signalling in the development of regulatory T cells. Moreover, CYLD appears to deubiquitylate SMAD7 at Lys360 and Lys374 but not at Lys64 or Lys70 [99]. Regulation of nuclear SMAD cofactors by reversible ubiquitylation Once the activated R-SMAD -SMAD4 complex is translocated into the nucleus, it must then bind promoter sequences to positively or negatively regulate the expression of TGFb response genes. However, SMAD proteins on their own rsob.royalsocietypublishing.org Open Biol 2: 120082 have low DNA-binding affinity and require other cofactors for DNA binding [16]. Additionally, as previously described, some nuclear adaptor proteins actually inhibit SMAD -DNA binding, thereby negatively regulating SMAD transcriptional activity. Therefore, reversible ubiquitylation of nuclear cofactors can modulate TGFb-induced transcriptional activity. RUNX2 is a transcription factor that promotes R-SMAD/ DNA binding in the BMP pathway. SMURF1 has been reported to induce its ubiquitylation and degradation [100]. SMURF1 is recruited to RUNX2 by its association with SMAD6 [101]. Most other reports have concentrated on the regulation of negative nuclear cofactors SKI and SnoN that antagonize SMAD-mediated transcriptional activity. TGFbinduced SMURF2/SMAD2 binding and targeting of SnoN release the negative regulation of SnoN on nuclear SMAD transcriptional activity in both physiological and pathological pathway signalling [33,102]. ARKADIA is reported to target both SKI and SnoN for ubiquitin-mediated degradation in a similar TGFb-dependent fashion, leading to activation of transcriptional responses [91,92]. Later reports also identify that SKI ubiquitylation and degradation requires TGFb signalling and ARKADIA binding to phosphorylated-SMAD2/3 [74,93]. ARKADIA function is itself regulated by binding to proteins such as AXIN and RB1CC1 [89,90]. The anaphase-promoting complex E3 ligase has also been reported to act in a similar manner by targeting SnoN [103,104], while the CDC34 E2 targets SKI and SnoN in a cell-cycle-dependent fashion [105]. Very little is known about the DUBs that reverse the ubiquitylation of the earlier-mentioned nuclear SMAD cofactors. Concluding remarks The TGFb family of cytokines influences the behaviour and fate of almost every cell type in vertebrates. The cellular responses to TGFb signals vary greatly depending on the biological context. Despite this, all cells share the fundamental transduction mechanisms of TGFb signalling. Various posttranslational modifications of key mediators of the TGFb pathway in response to multiple signals modulate their activity, stability and subcellular localization. The integration of different signals ultimately determines the extent and duration of cellular responses to TGFb signals. Reversible ubiquitylation of fundamental TGFb pathway mediators offers a key regulatory balance on the outcome of the pathway. Ubiquitylation confers a versatile modification of target proteins. This versatility is further augmented by the possibility of multiple types of ubiquitin chains that can be formed on target proteins. While K48-linked polyubiquitin chains have been described to cause proteasomal degradation of TGFb pathway components, the precise nature of polyubiquitin chains remains unexplored. Proteins that contain unique UBDs would be predicted to be essential for interpreting the signals contained within target proteins with unique polyubiquitin chains. In the TGFb pathway, few such proteins have been identified. Regulation of the TGFb pathway by ubiquitylation of key components has been widely reported (table 1). While many candidate E3 ubiquitin ligases have been proposed, little is known about the E2-ubiquitin-conjugating enzymes further upstream. Several members of the NEDD4-like family of E3 ubiquitin ligases have been reported to catalyse the polyubiquitylation and degradation of both TGFb receptors and SMAD transcription factors. Indeed, SMURF1/2 appears to be transcriptional targets of TGFb cytokines themselves and inhibit the pathway through a negative feedback loop [18]. The observations that the recognition of SMAD1 and SMAD2/3, by SMURF1 and NEDD4L, respectively, requires phosphorylation of linker regions of SMAD proteins imply an active interplay between phosphorylation and ubiquitylation processes [57,64]. Such crosstalk is likely to happen across Table 1. A summary of known E3 ubiquitin ligases and deubiquitylating enzymes (DUBs) involved in TGFb pathway signalling. Asterisks indicate E3s also targeting tail and/or linker-phosphorylated SMAD proteins. rsob.royalsocietypublishing.org Open Biol 2: 120082 multiple proteins and post-translational modifications as cells respond to a constant barrage of complex extra-cellular and intra-cellular signals. The knockout mouse models of several E3 ubiquitin ligases implicated in the TGFb pathway exist. SMURF1 knockout mice show enhanced bone mass upon ageing, phenotypes expected to result from enhanced BMP signalling [106]. While functional redundancy between SMURF1 and SMURF2 may have contributed to the lack of striking phenotypes in SMURF1-or SMURF2-knockout mice, double knockout resulted in embryonic lethality with severe defects in planar cell polarity [34,106,107]. As most E3 ubiquitin ligases implicated in the TGFb pathway are likely to have several substrates, observed phenotypes could be attributed to effects on their most critical targets, thereby confusing any impact relating to the TGFb pathway. Pathway-specific E3 mutants would therefore be required for such physiological studies relating to one pathway over any others targeted by E3 ligases. Understanding the molecular mechanisms by which the E3 ubiquitin ligases recognize specific substrates, and how they are activated, would be essential to producing such pathway-specific physiological mouse models. The precise mechanisms by which all reported E3 ubiquitin ligases are activated or recognize their substrates in the TGFb pathway are still not well defined. Deciphering the mechanisms of how TGFb receptor kinases mediate the phosphorylation of R-SMADs has resulted in our understanding of the fundamental aspects of TGFb signalling [1]. The precise ubiquitylation sites within receptors, SMAD proteins or SMAD cofactors as well as the nature of polyubiquitin chains that are attached to the initial ubiquitin are largely undefined. Most of the ubiquitylation sites reported on SMAD proteins thus far have resulted from over-expression and mutagenesis studies, which have the potential of yielding artefacts. Recent technologies capable of identifying ubiquitylated peptides on endogenous proteins hold great promise for investigating reversible ubiquitylation in the TGFb pathway [108,109]. Indeed one of these studies was able to identify multiple ubiquitylation sites within endogenous type I TGFb/BMP receptors as well as BMP and TGFb ligands. That the ligands could themselves be regulated by ubiquitylation is an intriguing observation that has as yet eluded consideration entirely. Investigation into the regulation of the TGFb pathway by DUBs is an emerging research field. To date, only three DUBs, namely UCH37, USP9X and USP15, have been attributed a role in deubiquitylating components of the TGFb pathway (table 1) [7,29,30,50]. The mode of substrate recognition and catalysis of reported TGFb pathway DUBs are still undefined. Because of their limited number in the genome, DUBs are likely to be promiscuous with regard to their substrate range. Therefore, RNAi-based global DUB knockdown strategies employed to identify TGFb pathway regulators have to be used cautiously. A better strategy would be to identify DUBs that associate directly with specific TGFb pathway components. Understanding the molecular mechanisms by which DUBs recognize their substrates is critical in defining their roles on specific targets. In addition to being peptidases, the DUBs possess a characteristic in being able to recognize and bind to uniquely ubiquitylated proteins or ubiquitin chains. This ability alone, regardless of their catalytic activity, may serve an important regulatory purpose during signalling by modulating the activity, subcellular localization or stability of the target protein. Indeed, recent reports demonstrate that DUBs influence protein function independently of their deubiquitylating activity. As an example, USP7 was demonstrated to increase the binding affinity of p53 to its target genes independent of its deubiquitylase activity [110]. Similar analogies may hold true for DUBs in the TGFb pathway. The TGFb pathway components are frequently compromised in numerous diseases, including fibrosis, cancer progression and metastasis [7,8,11,12,[31][32][33][34]94]. Therefore, understanding the molecular mechanisms by which reversible ubiquitylation regulates TGFb signalling may hold some therapeutic promise against these diseases. Amplification of several members of the NEDD4-like E3 ligases, including SMURF1/2, is reported to be associated with tumour progression [44]. Reduced ARKADIA activity is associated with the pathogenesis of colorectal cancers [11]. The efficacy of the proteasome inhibitor Bortezomib against B cell lymphoma demonstrates that ubiquitin ligases and the ubiquitylation system could be exploited as targets for anti-cancer therapies [111]. DUBs, which constitute the largest family of peptidases, are also associated with many human diseases, including cancer and could make attractive therapeutic targets [7,111,112]. Therefore, targeting the TGFb-pathway-specific E2-ubiquitin-conjugating enzymes, E3-ubiquitin ligases or DUBs for inhibition may provide opportunities for the development of therapies against diseases in which the TGFb pathway is compromised.

pes2o

{"added":"2016-05-04T20:20:58.661Z","created":"2012-05-01T00:00:00.000Z","id":"5814610","metadata":{"abstract":null,"abstract_count":null,"abstract_language":null,"abstract_perplexity":null,"extfieldsofstudy":["Biology","Medicine"],"provenance":"pes2o_v2-0008.json.gz:107212","s2fieldsofstudy":["Biology"],"sha1":"6f3898b704af60b43d91268b0ce7d4f50f19be7a","sources":null,"title":null,"title_count":null,"title_language":null,"title_perplexity":null,"top_frequencies":null,"year":2012},"source":"s2","version":"v3-fos"}

pes2o-12807920

Survival outcomes based on race in gastric carcinoma: A SEER database analysis. 5 Background: Gastric cancer is one of the leading causes of cancer related deaths worldwide with the incidence declining in the United States. However the prognosis remains poor with variable survivals being reported among different races. We analyzed the effect of race on patterns of disease presentation and survival rates using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS A total of 9,851 patients were diagnosed with gastric cancer from year 2004 to 2007 were identified from SEER database. Age, race, TNM staging, grade, treatment modalities utilized and cancer specific survival was collected. RESULTS Out of 9,851 patients, 64.63% were white, 12.17% were black, and 13.04% were Asian-Pacific islanders. Median age was 73 years for whites, 70 years in blacks, and 71 years in Asians. Sex distribution amongst races was more or less similar with 58.83% of whites, 59.47% of blacks, and 54.24% of Asians being men. 23.62% of whites had T1 lesions, 28.10% had T2, 19.58% were T3 and 28.70% had T4 lesions. 26.76% of blacks presented with T1 lesions, 26.63% with T2, 16.08% with T3 and 30.53% with T4. 18.69% of Asians had T1 lesions, 26.84% with T2, 23.44% had T3 and 31.03% had T4 lesions. 37.80% of whites, 36.70% of blacks, and 44.44% of Asians had lymph node involvement. Tumor grade was similar among all races. Surgery was performed in 31.49% of whites, 33.13% of blacks, and 40.48% of Asians. 14.68% of whites, 14.10% of blacks, and 19.43 % of all Asians underwent radiation therapy. Median overall survival in localized disease was 44 months, 43 months and 98 months (p < 0.0001) while in regional disease it was 16 months, 15 months and 23 months in whites, blacks and Asians respectively (p < 0.0001). Median survival in distant disease was 4 months in both whites and blacks; it was 5 months in Asians (p < 0.0001). CONCLUSIONS Cancer-specific survival in gastric carcinoma is significantly better in localized, regional and metastatic disease in Asians when compared to whites and blacks independent of T stage, grade, nodal involvement and treatment modalities utilized. The reason for this observation is unclear, exposure and genetic factors are potential causes and this needs to be investigated. No significant financial relationships to disclose.

pes2o

{"added":"2018-01-24T17:25:33.048Z","created":"2011-01-01T00:00:00.000Z","id":"20234444","metadata":{"abstract":"5 Background: Gastric cancer is one of the leading causes of cancer related deaths worldwide with the incidence declining in the United States. However the prognosis remains poor with variable survivals being reported among different races. We analyzed the effect of race on patterns of disease presentation and survival rates using the Surveillance, Epidemiology, and End Results (SEER) database.\n\n\nMETHODS\nA total of 9,851 patients were diagnosed with gastric cancer from year 2004 to 2007 were identified from SEER database. Age, race, TNM staging, grade, treatment modalities utilized and cancer specific survival was collected.\n\n\nRESULTS\nOut of 9,851 patients, 64.63% were white, 12.17% were black, and 13.04% were Asian-Pacific islanders. Median age was 73 years for whites, 70 years in blacks, and 71 years in Asians. Sex distribution amongst races was more or less similar with 58.83% of whites, 59.47% of blacks, and 54.24% of Asians being men. 23.62% of whites had T1 lesions, 28.10% had T2, 19.58% were T3 and 28.70% had T4 lesions. 26.76% of blacks presented with T1 lesions, 26.63% with T2, 16.08% with T3 and 30.53% with T4. 18.69% of Asians had T1 lesions, 26.84% with T2, 23.44% had T3 and 31.03% had T4 lesions. 37.80% of whites, 36.70% of blacks, and 44.44% of Asians had lymph node involvement. Tumor grade was similar among all races. Surgery was performed in 31.49% of whites, 33.13% of blacks, and 40.48% of Asians. 14.68% of whites, 14.10% of blacks, and 19.43 % of all Asians underwent radiation therapy. Median overall survival in localized disease was 44 months, 43 months and 98 months (p < 0.0001) while in regional disease it was 16 months, 15 months and 23 months in whites, blacks and Asians respectively (p < 0.0001). Median survival in distant disease was 4 months in both whites and blacks; it was 5 months in Asians (p < 0.0001).\n\n\nCONCLUSIONS\nCancer-specific survival in gastric carcinoma is significantly better in localized, regional and metastatic disease in Asians when compared to whites and blacks independent of T stage, grade, nodal involvement and treatment modalities utilized. The reason for this observation is unclear, exposure and genetic factors are potential causes and this needs to be investigated. No significant financial relationships to disclose.","abstract_count":370,"abstract_language":"en","abstract_perplexity":-17.628508186213793,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0003.json.gz:1192730","s2fieldsofstudy":["Medicine"],"sha1":"b0a49b05ba1aaf68083f4a2d09ad13f83c9a0f78","sources":["Medline","Unpaywall"],"title":"Survival outcomes based on race in gastric carcinoma: A SEER database analysis.","title_count":12,"title_language":"en","title_perplexity":-15.282127937548497,"top_frequencies":[{"count":22,"token":"of"},{"count":21,"token":"and"},{"count":14,"token":"in"},{"count":9,"token":"with"},{"count":9,"token":"was"},{"count":7,"token":"Asians"},{"count":7,"token":"had"},{"count":6,"token":"the"},{"count":6,"token":"were"},{"count":6,"token":"whites,"},{"count":6,"token":"months"},{"count":5,"token":"disease"},{"count":5,"token":"survival"},{"count":5,"token":"blacks,"},{"count":4,"token":"cancer"},{"count":4,"token":"to"},{"count":3,"token":"gastric"},{"count":3,"token":"is"},{"count":3,"token":"Median"},{"count":3,"token":"years"},{"count":3,"token":"whites"},{"count":3,"token":"T1"},{"count":3,"token":"lesions,"},{"count":3,"token":"T2,"},{"count":3,"token":"T3"},{"count":3,"token":"blacks"},{"count":3,"token":"(p"},{"count":3,"token":"<"},{"count":2,"token":"on"},{"count":2,"token":"race"},{"count":2,"token":"A"},{"count":2,"token":"SEER"},{"count":2,"token":"5"},{"count":2,"token":"causes"},{"count":2,"token":"being"},{"count":2,"token":"among"},{"count":2,"token":"races."},{"count":2,"token":"database."},{"count":2,"token":"9,851"},{"count":2,"token":"from"},{"count":2,"token":"grade,"},{"count":2,"token":"treatment"},{"count":2,"token":"modalities"},{"count":2,"token":"for"},{"count":2,"token":"Asians."},{"count":2,"token":"similar"},{"count":2,"token":"T4"},{"count":2,"token":"lesions."},{"count":2,"token":"all"},{"count":2,"token":"months,"},{"count":2,"token":"regional"},{"count":2,"token":"it"},{"count":2,"token":"0.0001)."},{"count":2,"token":"this"},{"count":1,"token":"Survival"},{"count":1,"token":"outcomes"},{"count":1,"token":"based"},{"count":1,"token":"carcinoma:"},{"count":1,"token":"database"},{"count":1,"token":"analysis."},{"count":1,"token":"Background:"},{"count":1,"token":"Gastric"},{"count":1,"token":"one"},{"count":1,"token":"leading"},{"count":1,"token":"related"},{"count":1,"token":"deaths"},{"count":1,"token":"worldwide"},{"count":1,"token":"incidence"},{"count":1,"token":"declining"},{"count":1,"token":"United"},{"count":1,"token":"States."},{"count":1,"token":"However"},{"count":1,"token":"prognosis"},{"count":1,"token":"remains"},{"count":1,"token":"poor"},{"count":1,"token":"variable"},{"count":1,"token":"survivals"},{"count":1,"token":"reported"},{"count":1,"token":"different"},{"count":1,"token":"We"},{"count":1,"token":"analyzed"},{"count":1,"token":"effect"},{"count":1,"token":"patterns"},{"count":1,"token":"presentation"},{"count":1,"token":"rates"},{"count":1,"token":"using"},{"count":1,"token":"Surveillance,"},{"count":1,"token":"Epidemiology,"},{"count":1,"token":"End"},{"count":1,"token":"Results"},{"count":1,"token":"(SEER)"},{"count":1,"token":"METHODS"},{"count":1,"token":"total"},{"count":1,"token":"patients"},{"count":1,"token":"diagnosed"},{"count":1,"token":"year"},{"count":1,"token":"2004"},{"count":1,"token":"2007"},{"count":1,"token":"identified"},{"count":1,"token":"Age,"}],"year":2011},"source":"s2","version":"v3-fos"}

flan-11115685

question: The leaders should submit to an independent and impartial court of law those among their combatants who are identified as having committed human rights abuses, subject to guarantees that they will get a fair trial and will not be ill-treated, sentenced to death or executed;

5.2.4 Leaders of armed political groups must issue clear public instructions to their combatants and commanders that human rights abuses, such as unlawful killings, abductions and torture, including rape, will not be tolerated. --> French. answer: En vertu de l’article 13 de la Déclaration, des enquêtes doivent être menées «tant que le sort de la victime d’une disparition forcée n’a pas été clarifié». Amnesty International est opposée au renvoi forcé de toute personne vers un pays où sa vie ou sa liberté serait menacée, et où elle pourrait être victime de violations graves de ses droits fondamentaux et risquer, notamment, d’être torturée, emprisonnée en raison de ses opinions, exécutée de façon extrajudiciaire ou condamnée à mort. question: (b) the State of origin, with the appropriate involvement of the operator, shall ensure that appropriate response measures are taken and should, for this purpose, rely upon the best available scientific data and technology; --> French. answer: b) L'État d'origine, avec, éventuellement, le concours de l'exploitant, veille à ce que des mesures d'intervention appropriées soient prises et devrait, à cet effet, faire appel aux données scientifiques et aux technologies optimales disponibles; question: Such an approach involves a rigorous competition policy that is geared to the development of innovation and which fully takes into account the dynamic and evolutionary nature of the knowledge economy and the global environment. --> French. answer: Une telle approche suppose une politique de la concurrence rigoureuse qui soit axée sur le développement de l’innovation et tienne pleinement compte de la nature dynamique et évolutive de l’économie de la connaissance et de l’environnement mondial. question: In fact they all appear to have originated from the Transavia Network (TAN Group) which originated in Ostende, Belgium. --> French. answer: En fait, les trois entités semblent issues de la Transavia Network (TAN Group) constituée à Ostende (Belgique).

flan

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wikipedia-2445092

The Great Seer The Great Seer (, also known as The Great Geomancer) is a 2012 South Korean historical television series, starring Ji Sung, Ji Jin-hee, Song Chang-eui, Kim So-yeon and Lee Yoon-ji. Set during the turbulent decline of Goryeo, it is about practicers of divination and the power that they hold over the fate of the country. It aired on SBS from October 10, 2012 to February 7, 2013 on Wednesdays and Thursdays at 21:55 for 35 episodes. Plot. "The Great Seer" begins during the reign of King Gongmin (Ryu Tae-joon). But despite being about seers, geomancers, divinators and the like, this drama is less about the fantasy and more about the political movers and shakers — people who had the power to advise, and therefore control, kings. Yi Seong-gye (Ji Jin-hee) is the general who led the overthrow of Goryeo and established the Joseon Dynasty, becoming its first king. Mok Ji-sang (Ji Sung) is a gifted seer/geomancer, born with the ability to see into people's pasts and futures. There are those who believe falsely that he has dark supernatural powers, thinking him possessed by ghosts. When he comes of age in the late Goryeo era, he becomes a scholar of divination, and a reader of geography, faces, and the like to tell fortunes — an area with much influence at the time. He eventually becomes a "king-maker," who holds the key to a major political shift in the overthrow of Goryeo and the rise of Joseon when he backs General Yi and effectively shapes the future of Korea as we know it. Lee Jung-geun (Song Chang-eui) is General Yi's other advisor and Ji-sang's rival. Hae-in (Kim So-yeon) is a healer whose destiny is tied to General Yi, but she falls in love with the seer. Ban-ya (Lee Yoon-ji) is a woman who was sold off as a gisaeng at a young age, but becomes a concubine to King Gongmin's advisor, and bears a son. King Gongmin takes in that son as his, and the boy becomes Woo of Goryeo (Lee Tae-ri) — the king that General Yi dethrones in a coup d'état. Promotions. To promote the series cast members Ji Jin-hee, Ji Sung and Song Chang-eui guest starred on the SBS Good Sunday variety show "Running Man" on episodes 116 and 117, which aired on October 21 and 28, 2012, along with Suzy of miss A and Yubin of Wonder Girls. International broadcast. It aired in Thailand on 3SD from June 13 to August 30, 2015, with reruns on Channel 3 beginning January 21, 2016.

wikipedia

{"added":"2023-04-02T20:40:41.324Z","created":"2023-04-02T20:40:41.324Z","id":"36223994","metadata":{"length":541,"provenance":"en_simple_wiki_v0-0000.json.gz:2445093","revid":"19485939","url":"https:\/\/en.wikipedia.org\/wiki?curid=36223994"},"source":"wikipedia","version":"v0"}

pes2o-5502859

Subsystem Density Functional Theory Augmented by a Delta Learning Approach to Achieve Kohn-Sham Accuracy. Simulations based on electronic structure theory naturally include polarization and have no transferability problems. In particular, Kohn-Sham density functional theory (KS-DFT) has become the method of reference for ab initio molecular dynamics simulations of condensed matter systems. However, the high computational cost often poses strict limits on the affordable system size as well as on the extension of sampling (number of configurations). In this work, we propose an improvement to the subsystem density functional theory approach, known as the Kim-Gordon (KG) scheme, thus enabling the sampling of configurations for condensed molecular systems keeping the KS-DFT level accuracy at a fraction of computer time. Our scheme compensates the known KG shortcomings of the electronic kinetic energy term by adding a simple correction and can match KS-DFT accuracy in energies and forces. The computationally cheap correction is determined by means of a machine learning procedure. The proposed KG scheme is applied within a linear scaling self-consistent field formalism and is assessed by a series of molecular dynamics simulations of liquid water under different conditions. Although system-dependent, the correction is transferable between system sizes and temperatures.

pes2o

{"added":"2021-09-11T06:17:07.705Z","created":"2021-09-10T00:00:00.000Z","id":"237472411","metadata":{"abstract":"Simulations based on electronic structure theory naturally include polarization and have no transferability problems. In particular, Kohn-Sham density functional theory (KS-DFT) has become the method of reference for ab initio molecular dynamics simulations of condensed matter systems. However, the high computational cost often poses strict limits on the affordable system size as well as on the extension of sampling (number of configurations). In this work, we propose an improvement to the subsystem density functional theory approach, known as the Kim-Gordon (KG) scheme, thus enabling the sampling of configurations for condensed molecular systems keeping the KS-DFT level accuracy at a fraction of computer time. Our scheme compensates the known KG shortcomings of the electronic kinetic energy term by adding a simple correction and can match KS-DFT accuracy in energies and forces. The computationally cheap correction is determined by means of a machine learning procedure. The proposed KG scheme is applied within a linear scaling self-consistent field formalism and is assessed by a series of molecular dynamics simulations of liquid water under different conditions. Although system-dependent, the correction is transferable between system sizes and temperatures.","abstract_count":183,"abstract_language":"en","abstract_perplexity":-14.079026739739984,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0001.json.gz:1640328","s2fieldsofstudy":["Computer Science"],"sha1":"37a4e4033bc648946f0db88d73ae4f4c3fdfa80b","sources":["Medline","Crossref"],"title":"Subsystem Density Functional Theory Augmented by a Delta Learning Approach to Achieve Kohn-Sham Accuracy.","title_count":14,"title_language":"en","title_perplexity":-15.572361935145466,"top_frequencies":[{"count":11,"token":"the"},{"count":10,"token":"of"},{"count":6,"token":"a"},{"count":5,"token":"and"},{"count":4,"token":"by"},{"count":4,"token":"is"},{"count":3,"token":"on"},{"count":3,"token":"theory"},{"count":3,"token":"molecular"},{"count":3,"token":"as"},{"count":3,"token":"correction"},{"count":2,"token":"to"},{"count":2,"token":"Kohn-Sham"},{"count":2,"token":"electronic"},{"count":2,"token":"In"},{"count":2,"token":"density"},{"count":2,"token":"functional"},{"count":2,"token":"for"},{"count":2,"token":"dynamics"},{"count":2,"token":"simulations"},{"count":2,"token":"condensed"},{"count":2,"token":"system"},{"count":2,"token":"sampling"},{"count":2,"token":"known"},{"count":2,"token":"KS-DFT"},{"count":2,"token":"accuracy"},{"count":2,"token":"scheme"},{"count":2,"token":"KG"},{"count":2,"token":"The"},{"count":1,"token":"Subsystem"},{"count":1,"token":"Density"},{"count":1,"token":"Functional"},{"count":1,"token":"Theory"},{"count":1,"token":"Augmented"},{"count":1,"token":"Delta"},{"count":1,"token":"Learning"},{"count":1,"token":"Approach"},{"count":1,"token":"Achieve"},{"count":1,"token":"Accuracy."},{"count":1,"token":"Simulations"},{"count":1,"token":"based"},{"count":1,"token":"structure"},{"count":1,"token":"naturally"},{"count":1,"token":"include"},{"count":1,"token":"polarization"},{"count":1,"token":"have"},{"count":1,"token":"no"},{"count":1,"token":"transferability"},{"count":1,"token":"problems."},{"count":1,"token":"particular,"},{"count":1,"token":"(KS-DFT)"},{"count":1,"token":"has"},{"count":1,"token":"become"},{"count":1,"token":"method"},{"count":1,"token":"reference"},{"count":1,"token":"ab"},{"count":1,"token":"initio"},{"count":1,"token":"matter"},{"count":1,"token":"systems."},{"count":1,"token":"However,"},{"count":1,"token":"high"},{"count":1,"token":"computational"},{"count":1,"token":"cost"},{"count":1,"token":"often"},{"count":1,"token":"poses"},{"count":1,"token":"strict"},{"count":1,"token":"limits"},{"count":1,"token":"affordable"},{"count":1,"token":"size"},{"count":1,"token":"well"},{"count":1,"token":"extension"},{"count":1,"token":"(number"},{"count":1,"token":"configurations)."},{"count":1,"token":"this"},{"count":1,"token":"work,"},{"count":1,"token":"we"},{"count":1,"token":"propose"},{"count":1,"token":"an"},{"count":1,"token":"improvement"},{"count":1,"token":"subsystem"},{"count":1,"token":"approach,"},{"count":1,"token":"Kim-Gordon"},{"count":1,"token":"(KG)"},{"count":1,"token":"scheme,"},{"count":1,"token":"thus"},{"count":1,"token":"enabling"},{"count":1,"token":"configurations"},{"count":1,"token":"systems"},{"count":1,"token":"keeping"},{"count":1,"token":"level"},{"count":1,"token":"at"},{"count":1,"token":"fraction"},{"count":1,"token":"computer"},{"count":1,"token":"time."},{"count":1,"token":"Our"},{"count":1,"token":"compensates"},{"count":1,"token":"shortcomings"},{"count":1,"token":"kinetic"},{"count":1,"token":"energy"},{"count":1,"token":"term"}],"year":2021},"source":"s2","version":"v3-fos"}

dclm-411893920

You are here Evaluation of the Vein Patient The history of the patient who presents with varicose veins will be symptoms of leg pain, leg swelling, leg cramps, or fatigue in the legs. Patients may also reports restless leg syndrome or itchy varicose veins. Their primary concern can be as simple as “Are varicose veins dangerous?” Significant considerations to the vein doctor include: family history of varicose veins or dvt, blood clotting disorders, age, pregnancy and gender. Occupation plays a large role in the development of varicose veins. Employment or lifestyles that require prolonged periods of sitting or standing are inciting factors for venous pooling and venous hypertension. Teachers, bus drivers, bank tellers, transit workers, clerical or office assistants tend to be prone to developing venous insufficiency. These professions tend to be a large majority of patients seen at the best vein clinics New Jersey. During the evaluation with a NJ vein doctor, it’s important not to lose track of the patients main concerns such as “eliminate spider veins” or “what is most important for you if we proceed with treatment?” For this reason, it’s important that before proceeding with any vein treatment, the vein specialist really consider what is causing the patient discomfort or pain. In the end, if the pain is related to sciatica, pain relief is unlikely with any cure for spider veins. Important vein specific features include leg swelling (especially if unilateral), prior DVT, prior episodes of superficial thrombophlebitis, and bleeding leg ulcerations. Vein treatment should also be considered in the context of important co-morbidities including cardiac disease such as prior myocardial infarctions, arrhythmias or heart failure. Vein treatment is elective and should not compromise a patient’s health status. Other considerations include diabetes, know history of blood clots or DVT, stroke, allergic reactions, musculoskeletal issues that can prove difficult for patient positioning. The vein doctor should also be aware of any mobility issues as it is important for patients to be able to recover post vein treatment with sufficient walking that promotes healthy circulation. Previous surgical history can be relevant especially if the patient has had prior vein stripping or radio-frequency ablation procedures. The physical examination cannot be overemphasized. Visual inspection for spider veins, varicose veins , and reticular veins will be obvious. The patient should also be inspected for skin discoloration, swelling, leg ulcerations. Scarring or pigmentation from prior ablation or sclerotherapy should also be inspected for. Advanced changes can include stasis dermatitis and even lipodermatosclerosis that in the presence of venous insufficiency should be considered by a vein specialist for treatment. These findings of vein disease form the basis of the CEAP classification of vein disease. These features of the history and physical examination are hallmarks of a comprehensive examination. Anyone looking for the best vein doctor near me should expect not only a board-certified vein specialist, but also an attentive doctor. Article Source:

dclm

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flan-23412060

III), le processus dynamique qui s'engage permet de mettre plus facilement en évidence les atteintes au droit à l'eau. Translate to English The following paragraphs provide illustrations of violations of the right to water.

flan

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dclm-426519571

In case you’re sad… Hey, kid. Today was shitty. There was nothing particularly epic or eventful– no real moment that defined it, but there was a low, gray cloud that hung firmly over the whole thing. I worked out for the first time in <unspeakable period of time> yesterday and then you decided to grow some molars, so we were up at the crack of ass this morning. I was tired and work was boring and the FedEx lady was unspeakably awful (and had ankles like a pregnant elephant) and traffic was unreasonable and then dinner never happened. I just wanted the whole thing to be over from about 8AM on. And then there was this article on my Facebook page. It was a beautiful young girl and she killed herself. And there was no amount of click-baiting that could get me to read it. Because I didn’t want to. I don’t ever want to. I don’t want to read about the ones who don’t make it, the ones whose sad becomes the only thing they know. Especially when they are young. So, so young. And then your dad told me this story about an 18-month-old who survived a tornado because her parents laid their bodies on top of her. They both died. It was meant to be a sad story with a happy ending, but he trailed off from the telling because we’d both just started watching you and imagining a world where we saved you, but we’d never see you again. So, like I was saying, today was shitty. Just because. Today was also shitty because I was depressed. I hope that you see sunshine in every dark corner of the world, sweet boy, but I am also realistic. You come from a long line of world-class crazies, sads, and worriers, and the chances that you will emerge unscathed are not stoutly in your favor. I hope they are, but hope is a frivolity… But even if you do escape with a clear mind and a light heart, I still want for you to understand what it can be like. Because your compassion will fight the good fight. It might even save a friend one day. For some of us, your Mups among them, the sun doesn’t always brighten the sky. We feel sad for reasons unknown or unseen, hopeless because we believe something the rest of the world cannot understand– maybe something that doesn’t even exist. There are days when–to me–there is no purpose, no reason, no motivation. My mind tells me things that I have no choice but to believe. I sometimes feel scared and sad. I sometimes forget which way is the sky. I forget that things pass, that the winds will shift the the seas will calm. In those moments, I am overwhelmed by the permanence of my darkness. I am convinced I have failed. I am nothing. But I am always something. Though it may seem like a tiny pinprick of light, an illusion or trick of the mind, the belief that I am something– whether it be to me or someone– is enough to keep me walking forward. The feelings will pass. The darkness will subside. Nothing is permanent. Always remember, nothing is permanent. If you every find yourself sad, remember that you are something. Visualize the tiniest point of light shining in the distant nothing and do not lose sight of it. Keep walking and waking until that tiny light becomes something– a new day, a friend, a hand, a doctor– something. Please, do not ever stop walking. More importantly, remember that being sad is okay. Say something. Tell someone. There is no shame in being sad, scared, worried, or anxious. Always, always tell someone. And if someone tells you they are sad, make eye contact with them and then tell them how wonderful they are. Show them compassion and understanding. Imagine that you are their tiny pinprick of light. They are walking; walk with them. I’ve learned something very valuable by writing things down here on this blog: all the people you think are sane, all the people you think are perfect, all the people you think have it all together– they are scared too. We’re all trying to figure it out– the optimists, the pessimists, the hopeful ones, and the depressed ones. Even the Republicans. If you one day find yourself depressed, whether it’s for a moment, a few days, or a battle that you fight always, I hope you find the courage to open up. I hope you find a reason to find a person (or a pill) to help you. The path doesn’t always get easier and there are times that the sun stays hidden for longer than you think you can hold on, but if we are only here this one time, and we only have this one chance, you deserve your turn. The world should be so lucky as to have you for as long as possible. Be kind. Be happy. Because I love you and I will always be your light. Walk towards me.

dclm

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flan-14002336

input hypothesis: Boston Legal starred James spader Context: Tony Shalhoub won best actor in a comedy for "Monk", and James Spader won best actor in a drama for "Boston Legal." OPTIONS: - Yes - It's impossible to say - No true or false: Yes Context: Sometimes he looked longingly at his mother , and sometimes he looked longingly at the window .<br>Certainly it would be pleasant to be her boy again , but on the other hand , what times those had been in the Gardens !<br>Was he so sure that he should enjoy wearing clothes again ?<br>He popped off the bed and opened some drawers to have a look at his old garments .<br>They were still there , but he could not remember how you put them on .<br>The socks , for instance , were they worn on the hands or on the feet ?<br>He was about to try one of them on his hand , when he had a great adventure . Hypothesis: He knows proper placement of attire. OPTIONS: - Yes - It's impossible to say - No No Input: OPTIONS: - Yes - It's impossible to say - No I'm a Born Liar: A Fellini Lexicon is a book combining film stills and photographs with transcripts of the last filmed interviews with Federico Fellini conducted by Canadian filmmaker Damian Pettigrew in Rome in 1991 and 1992. The interviews are edited and introduced by Pettigrew with a preface by Italian film critic and Fellini biographer Tullio Kezich. Sentence: I'm a Born Liar: A Fellini Lexicon is a book that attracted a lot of readers Output: It's impossible to say Problem: Read the following paragraph and determine if the hypothesis is true: The Arabic-language television network Al-Jazeera reports it has received a statement and a videotape from militants. OPTIONS: - Yes - It's impossible to say - No Hypothesis: Only video statement was received. **** Answer: No [Q]: Park Bo-gum (; born June 16, 1993) is a South Korean actor. He gained recognition for his diverse range of roles in film and television, notably, a psychopathic lawyer in "Hello Monster" (2015), a genius Go player in "Reply 1988" (2015–2016), and a Joseon Crown Prince in "Love in the Moonlight" (2016). Park Bo-gum is a man OPTIONS: - Yes - It's impossible to say - No [A]: Yes [Q]: When I see, for example, what they did with Dorval airport, where an agreement had almost been concluded with the Sret du Qubec to assume responsibility for airport security and the federal government stepped in and imposed the RCMP, you will understand that, because of the powers that will be given to our customs officers with Bill C-18, members of the Bloc Quebecois want to make sure that provincial jurisdictions are respected. Bloc Quebecois want to make sure that provincial jurisdictions are treated badly. OPTIONS: - Yes - It's impossible to say - No [A]: No

flan

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flan-12205704

Problem: Ces ressources ne doivent pas faire l'objet de conditions liées à des considérations politiques ou à des intérêts détachés des principes de l'assistance humanitaire. Which language is this? +++++ Language: French Problem: L’inscrit achète les livres qu’il revendra aux étudiants. Which language is this? +++++ Language: French Problem: Recommandations relatives à la structure du programme Which language is this? +++++ Language: French Problem: Éléments de données : but, couverture géographique, nombre de cas, période d’enregistrement, fréquence des mises à jour, accessibilité des données, forces, faiblesses et information sur les personnes-ressources. Which language is this? +++++ Language: French

flan

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flan-8163044

Text: newspapers here reported tuesday that turkish troops crossed into northern iraq to hunt down kurdish guerrillas , but the military denied the report . Summary: military denies turkish incursion into iraq Text: a defiant president robert mugabe vowed tuesday to continue seizing white-owned farms , saying a drought and growing international isolation , not his policies , were to blame for food shortages that threaten half the country with starvation . Summary: defiant mugabe blames drought international isolation for food shortages Text: the macedonian parliament late thursday voted in a new multi-ethnic government headed by prime minister-designate branko crvenkovski , whose party led the together for macedonia coalition to victory in september elections . Summary: macedonia gets new multi-ethnic government Text: portugal will allocate a greater share of the financial aid which it receives from the european union to worker training in order to boost the economy , prime minister jose socrates said wednesday . Summary: portugal to direct more eu funds to worker training

flan

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dclm-424884454

SKU: WC21-WK117 Category: Tags: , 117: The Nuts and Bolts of Creating a Safe Space for Those Impacted by Race-based Trauma Regina Chow Trammel, Ph.D. Azusa Pacific University 901 E Alosta Ave. Azusa, CA 91702 The FBI reported in August of 2021 that the number of hate crimes in the United States rose to its highest level in 12 years, totaling 7,759 crimes last year. These crimes were motivated by race/ethnicity/ancestry bias, particularly targeting Blacks and Asians. Some of these incidents were filmed, and the resulting videos were released and viewed by the general public as high-profile cases. Viewing these videos can evoke painful emotions and/or can raise questions that often go unanswered, leaving some of our Christian brothers and sisters feeling unsafe. With the increase in hate crimes and race-based encounters experienced by people of color and beyond, the need for lay counselors, clergy, and mental health professionals who are willing to create a safe space for feelings to be processed and understand the impacts of race-based trauma is needed. This workshop will create a safe space for attendees to learn more about the impact race-based trauma has in communities of color and the steps they can take to care for their brothers and sisters in Christ. Learning Objectives Participants will: • Provide an overview of historical and current impacts that racism, discrimination, and race-based trauma have in communities of color • Define race-based trauma and discuss examples of race-based encounters • Identify the key components and steps to create a safe space within therapy, including Christian mindfulness, for mental health professionals, clergy, and lay counselors alike. Additional information Media Type , ,

dclm

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flan-24011457

Translate to French: Through their assessment and discussions mandate-holders identify the root causes and various facets of emerging crisis and there are cases, for instance in the case of Rwanda in the early 90s and Liberia in 2002 where Special Rapporteurs who visited a given country have forewarned a crisis situation. Évaluations et discussions leur permettent d'identifier les causes profondes et les différents aspects d'une crise naissante; ainsi, les rapporteurs spéciaux qui se sont rendus dans certains pays ont prédit les crises qui allaient y survenir, comme dans le cas du Rwanda au début des années 90 ou du Libéria en 2002.

flan

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pes2o-22313209

The noise fluxes produced by the degree of first-order temporal coherence in a single mode class-A laser amplifier The noise feature of a single mode class-A laser is investigated in the presence (amplifier) and absence (free-running) of an input signal. The Maxwell-Bloch equations of motion have been solved after adding the cavity Langevin force to calculate fluctuations that imposed to the atomic population inversion and the amplitude and phase of cavity electric field. The correlation function of these fluctuations is then used to derive the spontaneous emission, amplitude, and phase noise fluxes in the below and above-threshold states. The bandwidth of noise fluxes is not only adjusted by the amplitude and frequency detuning of input signal, but also by the laser pumping and cavity damping rates. On the other hand, the degree of first-order temporal coherence (DFOTC) is turned out as the correlation function of the amplitude fluctuation so that its Fourier transform led to the amplitude noise flux. The coherence time plays a dual role in order that it is equal to the damping rate invers of DFOTC and at the same time has an uncertainty relation with the bandwidth of amplitude noise flux. Finally, the flux conservation requires a balance between the input pumping noise flux and the output amplitude and spontaneous emission noise fluxes.

pes2o

{"added":"2019-12-03T15:59:53.000Z","created":"2019-12-03T00:00:00.000Z","id":"208548377","metadata":{"abstract":"The noise feature of a single mode class-A laser is investigated in the presence (amplifier) and absence (free-running) of an input signal. The Maxwell-Bloch equations of motion have been solved after adding the cavity Langevin force to calculate fluctuations that imposed to the atomic population inversion and the amplitude and phase of cavity electric field. The correlation function of these fluctuations is then used to derive the spontaneous emission, amplitude, and phase noise fluxes in the below and above-threshold states. The bandwidth of noise fluxes is not only adjusted by the amplitude and frequency detuning of input signal, but also by the laser pumping and cavity damping rates. On the other hand, the degree of first-order temporal coherence (DFOTC) is turned out as the correlation function of the amplitude fluctuation so that its Fourier transform led to the amplitude noise flux. The coherence time plays a dual role in order that it is equal to the damping rate invers of DFOTC and at the same time has an uncertainty relation with the bandwidth of amplitude noise flux. Finally, the flux conservation requires a balance between the input pumping noise flux and the output amplitude and spontaneous emission noise fluxes.","abstract_count":199,"abstract_language":"en","abstract_perplexity":-13.394535079503148,"extfieldsofstudy":["Physics"],"provenance":"pes2o_v2-0005.json.gz:2950474","s2fieldsofstudy":["Physics"],"sha1":"9a48c6abf3a5c847ee58c8fd86346903c9ed3739","sources":["MergedPDFExtraction","ArXiv","MAG"],"title":"The noise fluxes produced by the degree of first-order temporal coherence in a single mode class-A laser amplifier","title_count":18,"title_language":"en","title_perplexity":-12.918726190215049,"top_frequencies":[{"count":20,"token":"the"},{"count":12,"token":"of"},{"count":10,"token":"and"},{"count":8,"token":"noise"},{"count":6,"token":"The"},{"count":6,"token":"amplitude"},{"count":5,"token":"is"},{"count":5,"token":"to"},{"count":4,"token":"in"},{"count":4,"token":"a"},{"count":3,"token":"fluxes"},{"count":3,"token":"by"},{"count":3,"token":"coherence"},{"count":3,"token":"laser"},{"count":3,"token":"input"},{"count":3,"token":"cavity"},{"count":3,"token":"that"},{"count":2,"token":"degree"},{"count":2,"token":"first-order"},{"count":2,"token":"temporal"},{"count":2,"token":"single"},{"count":2,"token":"mode"},{"count":2,"token":"class-A"},{"count":2,"token":"an"},{"count":2,"token":"fluctuations"},{"count":2,"token":"phase"},{"count":2,"token":"correlation"},{"count":2,"token":"function"},{"count":2,"token":"spontaneous"},{"count":2,"token":"bandwidth"},{"count":2,"token":"pumping"},{"count":2,"token":"damping"},{"count":2,"token":"flux."},{"count":2,"token":"time"},{"count":2,"token":"flux"},{"count":1,"token":"produced"},{"count":1,"token":"amplifier"},{"count":1,"token":"feature"},{"count":1,"token":"investigated"},{"count":1,"token":"presence"},{"count":1,"token":"(amplifier)"},{"count":1,"token":"absence"},{"count":1,"token":"(free-running)"},{"count":1,"token":"signal."},{"count":1,"token":"Maxwell-Bloch"},{"count":1,"token":"equations"},{"count":1,"token":"motion"},{"count":1,"token":"have"},{"count":1,"token":"been"},{"count":1,"token":"solved"},{"count":1,"token":"after"},{"count":1,"token":"adding"},{"count":1,"token":"Langevin"},{"count":1,"token":"force"},{"count":1,"token":"calculate"},{"count":1,"token":"imposed"},{"count":1,"token":"atomic"},{"count":1,"token":"population"},{"count":1,"token":"inversion"},{"count":1,"token":"electric"},{"count":1,"token":"field."},{"count":1,"token":"these"},{"count":1,"token":"then"},{"count":1,"token":"used"},{"count":1,"token":"derive"},{"count":1,"token":"emission,"},{"count":1,"token":"amplitude,"},{"count":1,"token":"below"},{"count":1,"token":"above-threshold"},{"count":1,"token":"states."},{"count":1,"token":"not"},{"count":1,"token":"only"},{"count":1,"token":"adjusted"},{"count":1,"token":"frequency"},{"count":1,"token":"detuning"},{"count":1,"token":"signal,"},{"count":1,"token":"but"},{"count":1,"token":"also"},{"count":1,"token":"rates."},{"count":1,"token":"On"},{"count":1,"token":"other"},{"count":1,"token":"hand,"},{"count":1,"token":"(DFOTC)"},{"count":1,"token":"turned"},{"count":1,"token":"out"},{"count":1,"token":"as"},{"count":1,"token":"fluctuation"},{"count":1,"token":"so"},{"count":1,"token":"its"},{"count":1,"token":"Fourier"},{"count":1,"token":"transform"},{"count":1,"token":"led"},{"count":1,"token":"plays"},{"count":1,"token":"dual"},{"count":1,"token":"role"},{"count":1,"token":"order"},{"count":1,"token":"it"},{"count":1,"token":"equal"},{"count":1,"token":"rate"},{"count":1,"token":"invers"}],"year":2019},"source":"s2","version":"v3-fos"}

dclm-415869636

Ghosla Roof Update: Paper Accepted to CAADRIA, 2013 This slideshow requires JavaScript. Here is a slide show and transcript of my talk – This slideshow requires JavaScript. Alternative Computation So what is it that computation offers? Welcome to the Craft Machine 2012-11-26 12.10.07 Option Explicit ‘Script written by <Ayodh Kamath> ‘Script version 18 November 2012 12:02:10 Call Main() Sub Main() Dim strStart, arrExist Dim arrDots, arrLines, strExit Dim i Call Rhino.AddLayer(“uncut_members”, RGB(0,255,0)) Call Rhino.CurrentLayer(“uncut_members”) arrExist = Rhino.AllObjects() If strStart = “S” Then If IsArray(arrExist) Then Call Rhino.DeleteObjects(arrExist) End If arrDots = Triangle(arrLines) Call Rhino.UnselectAllObjects arrDots = Tetrahedron(arrDots, arrLines) Call Rhino.UnselectAllObjects ElseIf strStart = “G” Then Call Rhino.ZoomExtents(,True) arrDots = Sort(arrDots) strExit = “A” arrDots = Tetrahedron(arrDots, arrLines) Call Rhino.UnselectAllObjects Loop While strExit <> “X” ElseIf strStart = “T” Then Call Triangulate(arrLines,arrDots) ElseIf strStart = “P” Then Call Panelize() End If Loop While strStart <> “X” End Sub Function Triangle(ByRef arrLines) Dim dblLt1, dblLt2, dblLt3 Dim strLn0, strLn1, strLn2 Dim strDotP0, strDotP1, strDotP2a, strDotP2b, strDotP2 Dim strTempCirc1, strTempCirc2 Dim arrInt, arrIntPt0, arrIntPt1, strPt0, strPt1, strPt2 Dim strChoice, blnLoop blnLoop = 0 Do While blnLoop = 0 dblLt1 = Rhino.GetReal(“Enter first lenght:”) Call Rhino.ZoomExtents(,True) dblLt2 = Rhino.GetReal(“Enter second lenght:”) strTempCirc1 = Rhino.AddCircle(Rhino.WorldXYPlane(),dblLt2) dblLt3 = Rhino.GetReal(“Enter third lenght:”) strTempCirc2 = Rhino.AddCircle(Rhino.WorldXYPlane(),dblLt3) arrInt = Rhino.CurveCurveIntersection(strTempCirc1,strTempCirc2) Call Rhino.DeleteObject(strTempCirc1) Call Rhino.DeleteObject(strTempCirc2) If IsArray(arrInt) Then arrIntPt0 = arrInt(0,1) arrIntPt1 = arrInt(1,1) strDotP2a = Rhino.AddTextDot(“P2a”,arrIntPt0) strDotP2b = Rhino.AddTextDot(“P2b”,arrIntPt1) Call Rhino.ZoomExtents(,True) If strChoice = “A” Then Call Rhino.DeleteObject(strDotP2b) Call Rhino.DeleteObject(strDotP2a) strDotP2 = Rhino.AddTextDot(“P2”,arrIntPt0) strLn1 = Rhino.AddLine(Rhino.CurveEndPoint(strLn0),arrIntPt0) strLn2 = Rhino.AddLine(arrIntPt0,Rhino.CurveStartPoint(strLn0)) ElseIf strChoice = “B” Then Call Rhino.DeleteObject(strDotP2a) Call Rhino.DeleteObject(strDotP2b) strDotP2 = Rhino.AddTextDot(“P2”,arrIntPt1) strLn1 = Rhino.AddLine(Rhino.CurveEndPoint(strLn0),arrIntPt1) strLn2 = Rhino.AddLine(arrIntPt1,Rhino.CurveStartPoint(strLn0)) End If Triangle = Array(strDotP0,strDotP1,strDotP2) ReDim arrLines(2) arrLines(0) = strLn0 arrLines(1) = strLn1 arrLines(2) = strLn2 blnLoop = 1 Call Rhino.DeleteObject(strLn0) Call Rhino.DeleteObject(strDotP0) Call Rhino.DeleteObject(strDotP1) End If End Function Function Sort(arrTxtDot) Dim strMin, blnSwap Dim i, j, k blnSwap = False For i = 1 To UBound(arrTxtDot) strMin = arrTxtDot(i) arrTxtDot(i) = arrTxtDot(i-1) arrTxtDot(i-1) = strMin blnSwap = True End If Loop While blnSwap = True Sort = arrTxtDot End Function Function Tetrahedron(arrTxtDots, ByRef arrLines) ReDim arrInPts(2) ReDim arrTempDots(2) ReDim arrInLts(2) ReDim arrTempSphs(2) Dim arrIntSrf, strJoinCrv, arrIntCrvSrf ReDim arrIntDots(1) Dim strChoice, arrIntPt Dim i, j Dim blnLoop Dim intPtNum Dim intCGChoice ReDim arrTempLines(2) Dim intLineCount Dim blnGoal, arrGoalPt blnLoop = 0 Do While blnLoop = 0 If blnGoal = “Y” Then arrGoalPt = Rhino.GetPoint(“Select goal point”) Call GoalPoint(arrTxtDots,arrGoalPt) End If For i = 0 To 2 Call Rhino.UnselectAllObjects Call Rhino.SelectObject(arrTempDots(i)) Call Rhino.ZoomExtents(,True) If i = 1 Then If IsArray(arrIntSrf) Then If UBound(arrIntSrf,1)>0 Then strJoinCrv = JoinCurve(arrIntSrf) strJoinCrv = arrIntSrf(0,1) End If Call Rhino.DeleteObject(arrTempDots(0)) Call Rhino.DeleteObject(arrTempDots(1)) Call Rhino.DeleteObject(arrTempSphs(0)) Call Rhino.DeleteObject(arrTempSphs(1)) blnLoop = 0 Exit For End If ElseIf i = 2 Then arrIntCrvSrf = Rhino.CurveSurfaceIntersection(strJoinCrv,arrTempSphs(2)) If IsArray(arrIntCrvSrf) Then blnLoop = 1 Call Rhino.SelectObjects(arrIntDots) If strChoice = “A” Then arrIntPt = arrIntCrvSrf(0,1) ElseIf strChoice = “B” Then arrIntPt = arrIntCrvSrf(1,1) End If Call Rhino.DeleteObjects(arrTempDots) Call Rhino.DeleteObjects(arrTempSphs) Call Rhino.DeleteObject(strJoinCrv) blnLoop = 0 Exit For End If End If Call Rhino.DeleteObjects(arrIntDots) Call Rhino.DeleteObjects(arrTempSphs) Call Rhino.DeleteObjects(arrTempDots) Call Rhino.DeleteObject(strJoinCrv) For i = 0 To 2 intLineCount = UBound(arrLines) ReDim Preserve arrLines(intLineCount+3) arrLines(intLineCount+1) = arrTempLines(0) arrLines(intLineCount+2) = arrTempLines(1) arrLines(intLineCount+3) = arrTempLines(2) intPtNum = UBound(arrTxtDots) ReDim Preserve arrTxtDots(intPtNum+1) intCGChoice = CG(arrTxtDots,arrLines) If intCGChoice = 7 Then Call Rhino.DeleteObjects(arrTempLines) Call Rhino.DeleteObject(arrTxtDots(intPtNum+1)) ReDim Preserve arrTxtDots(intPtNum) ReDim Preserve arrLines(intLineCount) End If Tetrahedron = arrTxtDots End Function Function JoinCurve(arrCrvs) Dim intSegments, arrJoin Dim i intSegments = UBound(arrCrvs,1) ReDim arrJoinCrvs(intSegments) For i = 0 To intSegments arrJoinCrvs(i) = arrCrvs(i,1) arrJoin = Rhino.JoinCurves(arrJoinCrvs, True) JoinCurve = arrJoin(0) End Function Function Triangulate(ByRef arrLines, arrTxtDots) Dim arrInPt1, arrInPt2, strTempDot1, strTempDot2, strTempLine Dim intMsg, intLineCount, intCGChoice arrInPt1 = Rhino.GetPoint(“Select first point”) strTempDot1 = Rhino.AddTextDot(“1”,arrInPt1) Call Rhino.SelectObject(strTempDot1) arrInPt2 = Rhino.GetPoint(“Select second point”) strTempDot2 = Rhino.AddTextDot(“2”,arrInPt2) Call Rhino.SelectObject(strTempDot2) If intMsg = 6 Then Call Rhino.AddLayer(“cut_members”, RGB(255,0,0)) Call Rhino.CurrentLayer(“cut_members”) intLineCount = UBound(arrLines) ReDim Preserve arrLines(intLineCount+1) Call Rhino.CurrentLayer(“uncut_members”) End If intCGChoice = CG(arrTxtDots,arrLines) If intCGChoice = 7 Then Call Rhino.DeleteObject(arrLines(intLineCount+1)) ReDim Preserve arrLines(intLineCount) End If Call Rhino.DeleteObject(strTempDot1) Call Rhino.DeleteObject(strTempDot2) End Function Function Panelize Dim strStart Dim strDot1, strDot2, strDot3 ReDim arrPts(2) Dim strSrf ReDim arrEdges(2) ReDim arrDgs(2) Dim arrTempDiv ReDim strDots(2) Dim intMsg, arrFlat, arrFlatOrPt, arrBox strDot1 = Rhino.GetObject(“Select first point”,8192) Call Rhino.SelectObject(strDot1) strDot2 = Rhino.GetObject(“Select second point”,8192) Call Rhino.SelectObject(strDot2) strDot3 = Rhino.GetObject(“Select third point”,8192) Call Rhino.SelectObject(strDot3) arrPts(0) = Rhino.TextDotPoint(strDot1) arrPts(1) = Rhino.TextDotPoint(strDot2) arrPts(2) = Rhino.TextDotPoint(strDot3) strSrf = Rhino.AddSrfPt(arrPts) arrTempDiv = Rhino.DivideCurve(arrDgs(0),4) arrTempDiv = Rhino.DivideCurve(arrDgs(1),4) arrTempDiv = Rhino.DivideCurve(arrDgs(2),4) Call Rhino.DeleteObjects(arrEdges) Call Rhino.DeleteObjects(arrDgs) Call Rhino.UnselectAllObjects() If intMsg = 7 Then Call Rhino.DeleteObject(strSrf) Call Rhino.DeleteObjects(strDots) ElseIf intMsg = 6 Then If Not IsArray(arrFlatOrPt) Then arrFlatOrPt = Rhino.GetPoint(“Select origin point for unroll”) End If arrFlat = RhinoUnrollSurface(strSrf,strDots,False,False) arrBox = Rhino.BoundingBox(arrFlat) arrFlatOrPt = arrBox(1) Call Rhino.DeleteObjects(strDots) End If End Function Function RhinoUnrollSurface(strSurface, arrCurves, blnExplode, blnLabels) ‘ Default return value RhinoUnrollSurface = Null ‘ For speed, turn of screen redrawing Call Rhino.EnableRedraw(False) ‘ Save any selected objects Dim arrSaved : arrSaved = Rhino.SelectedObjects ‘ Unselect all objects ‘ Select the surface to unroll Rhino.SelectObject strSurface ‘ Format curve string Dim i : i = 0 Dim strCurves : strCurves = ” _Enter” If IsArray(arrCurves) Then strCurves = “” For i = 0 To UBound(arrCurves) strCurves = strCurves & ” _SelId ” & arrCurves(i) strCurves = strCurves & ” _Enter” End If ‘ Format explode string Dim strExplode : strExplode = ” _Explode=_Yes” ‘ Format labels string Dim strLabels : strLabels = ” _Labels=_No” ‘ Script the command Call Rhino.Command(strCommand, 0) ‘ Return the results RhinoUnrollSurface = Rhino.LastCreatedObjects ‘ Unselect all objects ‘ If any objects were selected before calling ‘ this function, re-select them If IsArray(arrSaved) Then Rhino.SelectObjects(arrSaved) ‘ Don’t forget to turn redrawing back on Call Rhino.EnableRedraw(True) End Function Function CG(arrDots, ByRef arrLines) ReDim arrDotPts(UBound(arrDots)) Dim dblSumLength, arrMidPt Dim dblX, dblY, dblZ, dblLength Dim i ReDim arrMemCGPt(2) ReDim arrJtCGPt(2) ReDim arrCGPt(2) Dim strTempCGPt, strTempCGLine, intCount intCount = 0 ReDim arrBasePts(intCount) Dim arrSortBasePts, strBaseCrv, intInside, arrCGBasePt Dim intChoice Dim dblMemDens, dblJtWt For i = 0 To UBound(arrLines) dblSumLength = dblSumLength+Rhino.CurveLength(arrLines(i)) For i = 0 To UBound(arrLines) arrMidPt = Rhino.CurveMidPoint(arrLines(i)) dblLength = Rhino.CurveLength(arrLines(i)) arrMemCGPt(0) = dblX/dblSumLength arrMemCGPt(1) = dblY/dblSumLength arrMemCGPt(2) = dblZ/dblSumLength dblX = 0 dblY = 0 dblZ = 0 For i = 0 To UBound(arrDots) arrDotPts(i) = Rhino.TextDotPoint(arrDots(i)) dblX = dblX+arrDotPts(i)(0) dblY = dblY+arrDotPts(i)(1) dblZ = dblZ+arrDotPts(i)(2) arrJtCGPt(0) = dblX/i arrJtCGPt(1) = dblY/i arrJtCGPt(2) = dblZ/i strTempCGPt = Rhino.AddPoint(arrCGPt) strBaseCrv = Base(arrDotPts) arrCGBasePt = arrCGPt arrCGBasePt(2) = 0 strTempCGLine = Rhino.AddLine(arrCGPt,arrCGBasePt) intInside = Rhino.PointInPlanarClosedCurve(arrCGBasePt,strBaseCrv) Call Rhino.DeleteObject(strBaseCrv) If intInside <> 1 Then End If Call Rhino.DeleteObject(strTempCGPt) Call Rhino.DeleteObject(strTempCGLine) CG = intChoice End Function Function Base(arrAllPts) Dim intPolyCount, intPtCount, intInOut Dim i, j Dim arrTempPoly, strTempPoly Dim dblDist, dblMinDist, intMinPt, bolMin Dim dblParam, arrClsPt Dim arrTempPts Dim arrJoin intPtCount = 0 intPolyCount = 2 bolMin = 0 ReDim arrPts(intPtCount) ReDim arrBasePts(intPolyCount) ReDim arrBaseLns(intPolyCount) For i = 0 To UBound(arrAllPts) If arrAllPts(i)(2) = 0 Then arrPts(intPtCount) = arrAllPts(i) intPtCount = intPtCount+1 ReDim Preserve arrPts(intPtCount) End If intPtCount = intPtCount-1 ReDim Preserve arrPts(intPtCount) arrBasePts(0) = arrPts(0) arrBasePts(1) = arrPts(1) arrBasePts(2) = arrPts(2) For i = 3 To intPtCount arrTempPoly = Rhino.JoinCurves(arrBaseLns) strTempPoly = arrTempPoly(0) intInOut = Rhino.PointInPlanarClosedCurve(arrPts(i),strTempPoly) Call Rhino.DeleteObject(strTempPoly) If intInOut = 0 Then For j = 0 To intPolyCount If j = 0 Then dblMinDist = dblDist intMinPt = j bolMin = 0 If dblDist < dblMinDist Then dblMinDist = dblDist intMinPt = j bolMin = 0 End If End If For j = 0 To intPolyCount arrClsPt = Rhino.EvaluateCurve(arrBaseLns(j),dblParam) dblDist = Rhino.Distance(arrClsPt,arrPts(i)) If dblDist < dblMinDist Then dblMinDist = dblDist intMinPt = j bolMin = 1 End If If bolMin = 0 Then arrBasePts(intMinPt) = arrPts(i) Call Rhino.DeleteObjects(arrBaseLns) For j = 0 To intPolyCount-1 ElseIf bolMin = 1 Then arrTempPts = arrBasePts intPolyCount = intPolyCount+1 ReDim Preserve arrBasePts(intPolyCount) arrBasePts(intMinPt+1) = arrPts(i) For j = intMinPt+2 To intPolyCount arrBasePts(j) = arrTempPts(j-1) Call Rhino.DeleteObjects(arrBaseLns) ReDim Preserve arrBaseLns(intPolyCount) For j = 0 To intPolyCount-1 End If End If arrJoin = Rhino.JoinCurves(arrBaseLns,True) Base = arrJoin(0) End Function Function GoalPoint(arrTextDots,arrGoalPt) Dim strMin, blnSwap Dim i, j, k ReDim arrDist(UBound(arrTextDots)) blnSwap = False For i = 1 To UBound(arrTextDots) strMin = arrTextDots(i) arrTextDots(i) = arrTextDots(i-1) arrTextDots(i-1) = strMin blnSwap = True End If Loop While blnSwap = True Call Rhino.SelectObject(arrTextDots(0)) End Function The Anthropometry of Virtuality Ghosla Roof Construction Update Digitally Guided Weaving & Other Installations from the Spanz Workshop at SSAA. “Floating Triads”Canopy Design from the Spanz Workshop at Atharva 2012. Photograph: Yogesh Verma Lighting Module from the Spanz Workshop. Image: Pragya Vij, Saalanki Saraf A part of this semester’s 3rd year design studio at Sushant School of Art & Architecture consisted of an introductory workshop on the use of digital design tools that we called Spanz. The workshop was taught by Abhishek Bij and me (both visiting design faculty at the 3rd year design studio) and supported by the rest of the 3rd year design faculty consisting of Shikha Doogar, Gaurav Shorey, Swati Singh, Thomas Oomen and Neeraj Khosla. The workshop started with a crash course on a variety of digital design tools including 3D modelling software, form finding tools, parametric modelling software and form rationalization tools – tools that are applicable to different stages of the digital design workflow, from conceptualization to fabrication. The tools developed tackled a range of structural systems (tensile membranes, funicular shells and folded plates) and fabrication methods (weaving, pipe bending, sheet metal forming, concrete casting etc.). The students were encouraged to mix and matched these tools to suit their design goals and design styles and no specific methodology was imposed on them. The tools were applied to various real life campus development projects as a part of their annual college festival (Atharva 2012, 30th-31st March) and ranged from canopies to installations to lighting design. The nuances of the digital tools were mastered by them while using them for their developing their designs. The Interlace Installation. Photo: Gauri Varshney A student installation of specific interest here is “The Interlace” designed by Akshita, Anushree, Gauri, Parush, Sumit and Suvrita because it is the first time the weaving script I had developed and posted earlier has been applied to a large scale project. The weaving script simply takes a given fibre spacing and fibre thickness and uses the U- and V- curves of a surface to derive fabrication data for the weaving process. My interest in weaving comes from the way it allows complex 3D curved surfaces to be fabricated using only linear measurements (which I have discussed in detail in this earlier post). In “The Interlace” the students started out by using a form finding algorithm based on David Rutten’s classic mesh relaxation algorithm. The basic mesh relaxation algorithm was modified specifically for the workshop to allow the students to model the effects of gravity and thereby generate funicular forms in addition to tensile membranes (I will be explaining the modifications made to the algorithm in another blog post shortly). The relaxed mesh was converted to a NURBS surface and the weaving script was applied to it. The script outputted the lengths of individual fibres and the points of intersection with other fibres along their length. The fabrication data was used to first build a 1:10 scale construction model where the students could test the fabrication process and the steps involved. The 1:10 Construction Model Once the construction process was developed and understood in the studio, the students proceeded to build the final installation. Since the college festival is student-run and student-managed, the direct role of the design faculty ended at the construction model stage. Comparing the construction model to the final installation, it is interesting to note that the percentage error in the linear measurements was more in the construction model and less in the final installation, meaning that the final installation was a closer match to the computer model than the construction model. The properties of the pipe used to make the final installation were different from the construction model in terms of their ability to resist compression, resulting in a small amount of creasing of the surface of the final installation. Overall, however, this installation appears to verify the feasibility of using weaving to manually fabricate computer generated 3D curved surfaces at a 1:1 scale. Ghosla: A Curvature Optimized Woven Bamboocrete Roof “Ghosla” (meaning “nest” in Hindi) is a bamboocrete roof designed by Kamath Design Studio for a 150 square meter guest house unit at the Gnostic Centre in New Delhi, India. Curvature optimized weaving: Surface paths with minimum cumulative curvature compared to a UV transformed hexagonal grid The shape of the roof comes from a structural form-finding process dictated by the floor plan of the building and the resulting positions of the supporting columns. A RhinoScript was used to find optimized paths for woven members on this surface. The paths found using the script are those with minimum cumulative curvature passing through a given set of points on the surface. This enables the bamboo members used in the weaving to have as large a cross-sectional diameter as possible (and thus as high a load bearing capacity as possible) since they do not need to bend much and need not be extremely flexible. The advantage of using these optimized paths can be seen when comparing them (extreme right, above) to the simple UV transformed hexagonal grid (second from the right, above). The simple UV transformed grid has member paths with significantly higher curvature which will require more flexible (and thus thinner and weaker) bamboo members for its construction. Stepping back in the design process, the design-computational reason for constructing this roof by weaving bamboo came from the need to devise a work-flow and construction methodology that would enable the construction of a digitally designed complex curved surface (the form-found roof shape) by simple manual construction techniques in a non-industrial setting. Weaving is an ancient process that is in the technological repertoire of most cultures. What makes weaving especially suited to the construction of curved surfaces is the fact that it can use linear, one-dimensional elements to produce a surface curving in three-dimensions and requires only linear measurements during construction. I have discussed the details of this in my earlier post on Weaving and Linear Measurement in Digitally Guided Construction. The success of this digital-to-physical work-flow can be seen in the 1:25 scale model of the roof that was constructed by carpenter Ram Lakhan with the guidance of Inderjeet Singh Seera of Kamath Design Studio using linear dimensional information obtained from a 3D computer model of the woven roof. Here are some photographs of the model just before completion – 1:25 Scale Model of the Woven Bamboo Roof Under Construction 1:25 Scale Model of the Woven Bamboo Roof Under Construction 1:25 Scale Model of the Woven Bamboo Roof Under Construction While there is no doubt that there will be numerous challenges that will have to be overcome during full-scale construction, the progress on this project so far shows the ability of weaving to be used for the construction of complex curved surfaces by manual means using linear dimensional information. The bamboocrete roof that this woven structure will support will be similar to earlier bamboocrete roofs designed by Kamath Design Studio. The woven bamboo structure of the “Ghosla” roof will replace the steel and eucalyptus log trusses used to support these earlier roofs. Exterior View of the Bamboocrete Roof at the Kamath Residence Interior View of the Bamboocrete Roof at the Kamath Residence The First Parametric Pavilion This slideshow requires JavaScript. Photographs: Kamath Design Studio The first Parametric Pavilion was inaugurated as a part of the Anniversary Celebrations of the Gnostic Centre on the 28th of March. The pavilion forms an extention to the new conference centre also designed by Kamath Design Studio. Below are links to earlier posts about the design and construction of this project – February 21st, 2011: Parametric Pavilion Construction Update January 3rd, 2011: Parametric Pavilion Construction Progress November 21st, 2010: Parametric Pavilions Parametric Pavilion Construction Update The first Parametric Pavillion under construction in Delhi is nearing completion and should be ready for inaugration at the end of March. The bamboo work on the pavilion is now complete and the slate cladding and sand stone coping on the plinth remains to be done. Here are some photographs of the pavilion: This slideshow requires JavaScript. Photographs by Jaskirat Sangra, Kamath Design Studio. Parametric Pavilion Construction Progress Here are images of the Parametric Pavilion under construction. The work had stopped temporarily for the new year but should be re-starting today. This slideshow requires JavaScript. (Photographs by Anuradha Agarwal)

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pes2o-2765666

Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer. Eribulin mesylate (E7389) is a nontaxane microtubule dynamics inhibitor with a novel mechanism of action. In preclinical studies, it has activity in a variety of in vivo tumor model types, including breast cancer. Following promising results from phase I and phase II studies in patients with breast cancer, 2 open-label, randomized, controlled, parallelgroup phase III studies have been initiated, and enrollment has been completed. Both study populations comprise patients with locally advanced/recurrent or metastatic disease pretreated with several chemotherapy regimens, including an anthracycline and a taxane. In Study 305, eribulin is being evaluated as late-line therapy. The primary objective is to compare overall survival (OS) between eribulin monotherapy and treatment of the physician's choice, and progression-free survival (PFS) is one of the secondary objectives. The 762 patients enrolled in Study 305 were randomized in a 2:1 ratio to receive either eribulin or treatment of the physician's choice. In Study 301, eribulin is being assessed as second-line therapy, and the primary objective is to compare eribulin and capecitabine in terms of OS and PFS. Secondary objectives include assessments of response data, duration of response, quality of life, pain intensity, analgesic consumption, and assessment of pharmacokinetic/pharmacodynamic relationships for eribulin. In Study 301, the 1102 patients enrolled were randomized to receive either eribulin or capecitabine (approximately 550 patients in each arm). Tumor assessments are carried out every 8 weeks in Study 305, and every 2 cycles (each of 3 weeks' duration) in Study 301. Safety is also assessed in both studies.

pes2o

{"added":"2018-04-03T05:18:09.232Z","created":"2010-04-01T00:00:00.000Z","id":"207642510","metadata":{"abstract":"Eribulin mesylate (E7389) is a nontaxane microtubule dynamics inhibitor with a novel mechanism of action. In preclinical studies, it has activity in a variety of in vivo tumor model types, including breast cancer. Following promising results from phase I and phase II studies in patients with breast cancer, 2 open-label, randomized, controlled, parallelgroup phase III studies have been initiated, and enrollment has been completed. Both study populations comprise patients with locally advanced\/recurrent or metastatic disease pretreated with several chemotherapy regimens, including an anthracycline and a taxane. In Study 305, eribulin is being evaluated as late-line therapy. The primary objective is to compare overall survival (OS) between eribulin monotherapy and treatment of the physician's choice, and progression-free survival (PFS) is one of the secondary objectives. The 762 patients enrolled in Study 305 were randomized in a 2:1 ratio to receive either eribulin or treatment of the physician's choice. In Study 301, eribulin is being assessed as second-line therapy, and the primary objective is to compare eribulin and capecitabine in terms of OS and PFS. Secondary objectives include assessments of response data, duration of response, quality of life, pain intensity, analgesic consumption, and assessment of pharmacokinetic\/pharmacodynamic relationships for eribulin. In Study 301, the 1102 patients enrolled were randomized to receive either eribulin or capecitabine (approximately 550 patients in each arm). Tumor assessments are carried out every 8 weeks in Study 305, and every 2 cycles (each of 3 weeks' duration) in Study 301. Safety is also assessed in both studies.","abstract_count":248,"abstract_language":"en","abstract_perplexity":-16.213476504929208,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0000.json.gz:2765667","s2fieldsofstudy":["Medicine"],"sha1":"b95d207b282f739e2e92d021d100891c372b8e36","sources":["Medline","MAG","Unpaywall","ScienceParseMerged"],"title":"Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer.","title_count":18,"title_language":"en","title_perplexity":-17.809603264939653,"top_frequencies":[{"count":12,"token":"of"},{"count":11,"token":"in"},{"count":10,"token":"and"},{"count":7,"token":"eribulin"},{"count":7,"token":"is"},{"count":6,"token":"patients"},{"count":6,"token":"Study"},{"count":5,"token":"with"},{"count":5,"token":"a"},{"count":5,"token":"the"},{"count":4,"token":"or"},{"count":4,"token":"In"},{"count":4,"token":"to"},{"count":3,"token":"breast"},{"count":3,"token":"phase"},{"count":2,"token":"III"},{"count":2,"token":"mesylate"},{"count":2,"token":"(E7389)"},{"count":2,"token":"pretreated"},{"count":2,"token":"locally"},{"count":2,"token":"metastatic"},{"count":2,"token":"cancer."},{"count":2,"token":"has"},{"count":2,"token":"including"},{"count":2,"token":"studies"},{"count":2,"token":"2"},{"count":2,"token":"been"},{"count":2,"token":"305,"},{"count":2,"token":"being"},{"count":2,"token":"as"},{"count":2,"token":"The"},{"count":2,"token":"primary"},{"count":2,"token":"objective"},{"count":2,"token":"compare"},{"count":2,"token":"survival"},{"count":2,"token":"treatment"},{"count":2,"token":"physician's"},{"count":2,"token":"enrolled"},{"count":2,"token":"were"},{"count":2,"token":"randomized"},{"count":2,"token":"receive"},{"count":2,"token":"either"},{"count":2,"token":"301,"},{"count":2,"token":"assessed"},{"count":2,"token":"capecitabine"},{"count":2,"token":"assessments"},{"count":2,"token":"every"},{"count":1,"token":"Phase"},{"count":1,"token":"trials"},{"count":1,"token":"extensively"},{"count":1,"token":"recurrent"},{"count":1,"token":"Eribulin"},{"count":1,"token":"nontaxane"},{"count":1,"token":"microtubule"},{"count":1,"token":"dynamics"},{"count":1,"token":"inhibitor"},{"count":1,"token":"novel"},{"count":1,"token":"mechanism"},{"count":1,"token":"action."},{"count":1,"token":"preclinical"},{"count":1,"token":"studies,"},{"count":1,"token":"it"},{"count":1,"token":"activity"},{"count":1,"token":"variety"},{"count":1,"token":"vivo"},{"count":1,"token":"tumor"},{"count":1,"token":"model"},{"count":1,"token":"types,"},{"count":1,"token":"Following"},{"count":1,"token":"promising"},{"count":1,"token":"results"},{"count":1,"token":"from"},{"count":1,"token":"I"},{"count":1,"token":"II"},{"count":1,"token":"cancer,"},{"count":1,"token":"open-label,"},{"count":1,"token":"randomized,"},{"count":1,"token":"controlled,"},{"count":1,"token":"parallelgroup"},{"count":1,"token":"have"},{"count":1,"token":"initiated,"},{"count":1,"token":"enrollment"},{"count":1,"token":"completed."},{"count":1,"token":"Both"},{"count":1,"token":"study"},{"count":1,"token":"populations"},{"count":1,"token":"comprise"},{"count":1,"token":"advanced\/recurrent"},{"count":1,"token":"disease"},{"count":1,"token":"several"},{"count":1,"token":"chemotherapy"},{"count":1,"token":"regimens,"},{"count":1,"token":"an"},{"count":1,"token":"anthracycline"},{"count":1,"token":"taxane."},{"count":1,"token":"evaluated"},{"count":1,"token":"late-line"},{"count":1,"token":"therapy."},{"count":1,"token":"overall"},{"count":1,"token":"(OS)"}],"year":2010},"source":"s2","version":"v3-fos"}

dclm-412408265

An article is completed by sentences. Once they have been in the center college as much as the college pupils learn how to create sentences. Publishing that is section is consequently extremely important. In academics’ reduced degrees, pupils realize that several sentences are consisted of by a composition. A several section composition offers the summary, physique and the intro. In the college-level, composition publishing is more complex. Pupils have to create various kinds of documents. The documents are created utilizing business and distinctive platforms. Among the well-known buildings used-to create may be the several section structure. But before anyone property a section essay’s exemplary instance, let us discover how it’s created. This is actually the initial section. An intro is intended to drop several gentle towards the visitors. It has information that is short on the essay’s name. Your intro should not be missed inside by a dissertation declaration. It requires the introduction’s final part. Consequently, an intro is not changed in by anything. Finally, allow it to be so that is fascinating that the audience’s interest is grabbed by it. Several part composition Once they notice of the several sentence composition numerous pupils is likely to be amazed. Unwind; there is nothing extra-ordinary about any of it. Pupils nevertheless keep up with the regular structure of physique, an intro and summary. Let us look at every section in particulars. This is actually the final section and the sixth. Below, restate anyone dissertation and provide a listing of the several factors mentioned previously. The stage that was second is offered within the section that was next. Examine your stage that is second and compliment it using proof. You need to preserve a purchase of one’s factors. You might start with even the poorest or the best. The thing that is main is to comprehend the essay’s circulation. This can be an area providing you with visitors with comprehensive info. It consequently needs to be educational and prolonged sufficient. Getting launched the factors to go over inside your document; the factors have to be offered in sentences that are individual. The very first stage is mentioned following the intro within the next section. Create your stage obvious and supply information that is comprehensive on it. Inside your section, utilize proof to back your factors up. You should use details and data, estimates that have been mentioned about them. The final and third stage is mentioned within the section that was next. Based on a selected purchase, it could retain quarrels and the poorest stage. Evidence anyone supply may also function as the poorest. Pupils that are additional may also decide to complete using the factors that are best. Below, proof as an existing best justifications back up. Incorporate a changeover inside the sentences to steadfastly keep up the essay’s circulation. FIVE part essay format theme When composing a document a 5-section composition define theme instructions pupils. The theme has been created easy so that pupils think it is easier to build the sentences. Where do I get a FIVE-section composition test? Obtain types of section essays. We managed to get simpler for pupils to comprehend what components they have and how sentences are built. Too much is contributed by section format to the paper’s achievement. A typical example of a several section composition can make pupils know very well when performing their very own documents what is needed of these. Several section composition sample is available in groups that are various, we have expository composition sample amongst others, a several section powerful composition test. Guidelines used-to create several sentence essay test Feel large The distinction between the additional pupil and anyone may be the creativeness you have. Written down discover the areas and documents attempt to believe beyond the container. Into composing what has been trained in course pupils often restrain themselves. Discuss over it before beginning composing after selecting an article subject. It is probably you collect your factors, which are caught within the subconscious and will discover the subject acquainted. Modify your document Study word phrase, by-word by phrase if everything is proper and examine. Examine its own business and the phrases framework. Eliminate lexical mistakes, which make the document audio uncomfortable and easy punctuation errors. Editing is currently going during your document to make sure it moves as much as the ultimate stage. Request a friend to see it is subsequently submitted by your document. At-least when your document reaches the teacher that you do not need certainly to fret. Everything must certainly not be imperfect in composition writing. Leave a Reply

dclm

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pes2o-29390373

Calibration of Sensing Coils of a Three-Dimensional Magnetic Property Tester For electrical machines with three-dimensional (3-D) magnetic fluxes, the magnetic properties of magnetic materials under 3-D excitations should be properly determined and applied in machine design and analysis. This paper presents the construction and calibration of the H (field strength) and B (flux density) sensing coils of a 3-D magnetic property testing system, and the correction of measurement error due to the misalignment of sensing coils with excitation fields. The 3-D tester has been used to measure the magnetic properties of soft magnetic composite (SMC), a material specially developed for application of 3-D flux electrical machines. Some 3-D results have been obtained on a cubic SMC sample. The measurement errors caused by the misalignment of sensing coils and excitation fields are corrected by a rotational transformation of coordinates

pes2o

{"added":"2017-02-20T06:12:22.739Z","created":"2006-05-08T00:00:00.000Z","id":"62785919","metadata":{"abstract":"For electrical machines with three-dimensional (3-D) magnetic fluxes, the magnetic properties of magnetic materials under 3-D excitations should be properly determined and applied in machine design and analysis. This paper presents the construction and calibration of the H (field strength) and B (flux density) sensing coils of a 3-D magnetic property testing system, and the correction of measurement error due to the misalignment of sensing coils with excitation fields. The 3-D tester has been used to measure the magnetic properties of soft magnetic composite (SMC), a material specially developed for application of 3-D flux electrical machines. Some 3-D results have been obtained on a cubic SMC sample. The measurement errors caused by the misalignment of sensing coils and excitation fields are corrected by a rotational transformation of coordinates","abstract_count":128,"abstract_language":"en","abstract_perplexity":-14.814413221003925,"extfieldsofstudy":["Materials Science"],"provenance":"pes2o_v2-0007.json.gz:2283777","s2fieldsofstudy":["Physics","Materials Science"],"sha1":"0480150fa6bf4454240396bdaf1bb638e93dc450","sources":["Unpaywall","IEEE","Anansi","MergedPDFExtraction","MAG"],"title":"Calibration of Sensing Coils of a Three-Dimensional Magnetic Property Tester","title_count":10,"title_language":"en","title_perplexity":-14.162488239084748,"top_frequencies":[{"count":11,"token":"of"},{"count":7,"token":"the"},{"count":6,"token":"magnetic"},{"count":6,"token":"and"},{"count":5,"token":"a"},{"count":5,"token":"3-D"},{"count":3,"token":"sensing"},{"count":3,"token":"coils"},{"count":2,"token":"electrical"},{"count":2,"token":"with"},{"count":2,"token":"properties"},{"count":2,"token":"measurement"},{"count":2,"token":"to"},{"count":2,"token":"misalignment"},{"count":2,"token":"excitation"},{"count":2,"token":"The"},{"count":2,"token":"been"},{"count":2,"token":"by"},{"count":1,"token":"Calibration"},{"count":1,"token":"Sensing"},{"count":1,"token":"Coils"},{"count":1,"token":"Three-Dimensional"},{"count":1,"token":"Magnetic"},{"count":1,"token":"Property"},{"count":1,"token":"Tester"},{"count":1,"token":"For"},{"count":1,"token":"machines"},{"count":1,"token":"three-dimensional"},{"count":1,"token":"(3-D)"},{"count":1,"token":"fluxes,"},{"count":1,"token":"materials"},{"count":1,"token":"under"},{"count":1,"token":"excitations"},{"count":1,"token":"should"},{"count":1,"token":"be"},{"count":1,"token":"properly"},{"count":1,"token":"determined"},{"count":1,"token":"applied"},{"count":1,"token":"in"},{"count":1,"token":"machine"},{"count":1,"token":"design"},{"count":1,"token":"analysis."},{"count":1,"token":"This"},{"count":1,"token":"paper"},{"count":1,"token":"presents"},{"count":1,"token":"construction"},{"count":1,"token":"calibration"},{"count":1,"token":"H"},{"count":1,"token":"(field"},{"count":1,"token":"strength)"},{"count":1,"token":"B"},{"count":1,"token":"(flux"},{"count":1,"token":"density)"},{"count":1,"token":"property"},{"count":1,"token":"testing"},{"count":1,"token":"system,"},{"count":1,"token":"correction"},{"count":1,"token":"error"},{"count":1,"token":"due"},{"count":1,"token":"fields."},{"count":1,"token":"tester"},{"count":1,"token":"has"},{"count":1,"token":"used"},{"count":1,"token":"measure"},{"count":1,"token":"soft"},{"count":1,"token":"composite"},{"count":1,"token":"(SMC),"},{"count":1,"token":"material"},{"count":1,"token":"specially"},{"count":1,"token":"developed"},{"count":1,"token":"for"},{"count":1,"token":"application"},{"count":1,"token":"flux"},{"count":1,"token":"machines."},{"count":1,"token":"Some"},{"count":1,"token":"results"},{"count":1,"token":"have"},{"count":1,"token":"obtained"},{"count":1,"token":"on"},{"count":1,"token":"cubic"},{"count":1,"token":"SMC"},{"count":1,"token":"sample."},{"count":1,"token":"errors"},{"count":1,"token":"caused"},{"count":1,"token":"fields"},{"count":1,"token":"are"},{"count":1,"token":"corrected"},{"count":1,"token":"rotational"},{"count":1,"token":"transformation"},{"count":1,"token":"coordinates"}],"year":2006},"source":"s2","version":"v3-fos"}

dclm-426583845

What is a Flat Screen Television? B. Miller A flat screen television is a type of television that is only a few inches thick and has a perfectly flat screen, not the slightly curved screen that was used on older CRT models. These are also referred to as flat panel televisions, and are available in LCD and plasma varieties. Flat panel displays refer to computer monitors in this flat screen design. A flat screen television is a very popular choice for many homes, due in large part to its traditionally excellent picture quality and wide range of options. Flat screen televisions are TVs that have flat screens and are usually only a few inches thick. In general, LCD televisions come in smaller versions, whereas plasma televisions come in larger sizes. However, this gap is becoming less and less common, and it is now possible to get LCD or plasma televisions in virtually any size. A flat screen television is almost always a widescreen television, meaning it has a 16:9 aspect ratio rather than the 4:3 aspect ratio of older televisions. Aspect ratio simply refers to the width compared to the height of the television. Most flat screen televisions support wide-formatting. Most flat screen televisions support wide-formatting. For this reason, these televisions are great choices for movies, which are often displayed in a widescreen format. Many television shows are also now being broadcast in widescreen formats, due to the large number of people who own a flat screen television. These televisions are typically high definition as well, and are manufactured in 720p or 1080p varieties. This refers to the screen resolution and references the amount of pixels in the screen; 720p is available in 1,366 by 768 or 1,024 by 768 resolution, whereas 1080p is 1,920 by 1,080. 1080p is "true" high definition, and is the resolution that high-definition discs are displayed in. In general, plasma screens tend to work best in darker rooms, whereas LCD screens are brighter and may work better in sunnier rooms. There are many websites that offer lengthy buying guides with additional, much more detailed information regarding screen size and resolution, as well as other considerations when purchasing this type of television, and it is a good idea to research these buying guides before making a purchase. Flat screen televisions are typically quite expensive, but they vary widely in price based on quality, size, and features. Keep in mind that a large television with a flat screen will need a stand designed to hold it safely, and some can be quite difficult to set up. It is also possible to mount a flat screen television on the wall, which can be a great way to save space. You might also Like Discuss this Article Post your comments Forgot password?

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wikipedia-6131943

Teresa Leger Fernandez Teresa Leger Fernandez (born July 1, 1959) is an American attorney and politician. She is the Representative for New Mexico's 3rd congressional district in the United States House of Representatives since 2021.

wikipedia

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dclm-421882437

Support 100 years of independent journalism. 1. Spotlight 22 October 2018updated 16 Sep 2021 4:52pm Why better buses are just the start By Steven Meersman Over the past few months, the UK has seen a huge push from the public, both young and old, for decisive action on climate change. Whilst the transition to renewable energy has led to a reduction in emissions, little progress has been made in energy-intensive sectors, such as transport, to reduce our carbon footprint and air quality in our cities. Recently the Committee on Climate Change (CCC) recommended an ambitious target for the UK to become carbon-neutral by 2050. To meet this target, both government bodies and private companies must transition towards a smart, low-carbon, decentralised energy system, as soon as possible. Transport accounts for 34 per cent of carbon dioxide emissions. We must therefore look to invest in new technologies and initiatives, including the electrification of public transport and last mile deliveries, as well as other forms of transport. The rollout of the first battery-assisted electric bus fleet in the country occurred in Guildford in January of this year, implemented by Zenobe Energy, in conjunction with Stagecoach and Surrey County Council. Rather than waiting for an expensive grid upgrade, this scheme uses battery storage to support the constrained local power grid. The battery charges up during the day from the current grid connection and gives power to buses at night, so that they are ready to go in the morning. Initiatives such as this are already making a considerable difference in regional areas, by improving air quality and reducing carbon emissions. They provide a dual benefit for both our transport and energy objectives – at night it dampens the peak caused by bus charging and during the day it supports the local network enabling more renewables. The use of energy storage or on-site renewables also avoids rising grid charges through optimising large energy users grid consumption. These grid charges increasingly contribute as much as 40 per cent of energy bills and are caused by an overall inefficiency on our grid. The CCC has stressed that in order to meet carbon reduction targets, grid capacity should be significantly increased and policy and regulatory frameworks must encourage innovation, like demand response and storage. However, recent proposed changes, such as the Targeted Charging Review, could dampen innovation and hurt investment in renewables, derailing our transition to a carbon-neutral future, in line with our commitments. For the UK to continue to lead this charge system thinking is vital. Policymakers and regulators must provide a clear mandate that encourages new, flexible, renewable technologies focusing on long-term benefits and costs rather than short-term, often disjointed, objectives. Content from our partners Transport is the core of levelling up The forgotten crisis: How businesses can boost biodiversity Small businesses can be the backbone of our national recovery While schemes such as the EV fleet in Guildford and the London Mayor’s recent Ultra-Low Emission Zone are a great start, they are not enough. Companies and government bodies across the UK need to look at rolling these out nationwide. Partnerships between local councils and private companies can ultimately help maximise the benefit of infrastructure for the whole community, lowering costs, improving air quality and reducing our carbon footprint. Steven Meersman is the founder of Zenobe Energy.

dclm

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dclm-428975773

Cornwall seal Cornwall flag Name Cornwall Hexacode CL-ED-02 Population 916 Language(s) English Next to Abington Nicknames New Corny, New Cornwall Cornwall Sign Cornwall is a village located on the east coast of Asian Island in the state of Clymene. The settlement was founded in 1918 by Cornish and English immigrants from the United Kingdom. Overtime the settlement has stayed small but played a role in being a docking, fishing, and seaside town. While assimilating into the English language and Lovian culture, since most spoke Cornish in the beginning, the town still has strong cultural roots to British culture. Geography Edit Rider Mountain Cornwall is a Village located on the coast of Asian Island with a very low elevation because it is located on the sea. The water surrounding the Island allows for fishing of tuna and box fish. The geography has allowed for the shipping of goods to Seven and then statewide trade them to economic hubs like Sofasi and Plains. There is one tall mountain nearby called Rider Mountain which serves for tourism and beauty in the Village. History Edit An original poster which was posted in town pubs in Cornwall. The Hamlet was founded through a State plan to build a new fishing and docking settlement on the east coast of Asian Island to get new settlers there and help the economy of the area and state. The Board for Cornish Expansion in Lovia was set up by Cornish politicians and Clymene Governor Geoffrey Rider to make a new settlement in 1915. The Board decided to send over 250 settlers to Clymene in 1917 which reached the new settlement in 1918. By the time they reached the settlement some of it was already built up including townhouses and the construction of docks. The workers which had started were also British or American so they decided to live in Cornwall as well. At the time the settlement was called "New Cornwall" since the majority of the settlers were from Cornwall and thought it shouldn't directly be named after the old country. This sparked a long political streak within the Hamlet which included various referendums and battling the state level for their rights. In the Cornwall naming referendum, 1929 the settlers in the town chose the name of "Cornwall" over "New Cornwall", 57% to 43%. Besides the naming issue, the town was hit hard by the great depression. One of the reasons the referendum was approved was that a Yes vote would result in new signs and street signs to be made and create jobs during an economic depression. The depression hit hard in the area as the docking and shipping jobs went elsewhere in the country and most banks closed in the Hamlet. Population dipped from 479 to 294 and while unemployment had risen fast, it had gone back down by 1940. Official state map clymene Cornwall located on the east coast of Clymene The hamlet recovered through a series of financial matters which helped saved the city in a fast manner. The governors over time along with City leaders on the Cornwall Council had created an alternative economy which included nationalizing all economic matters dealing with the bay area into the Cornwall Water Industry. This helped save many jobs and keep people in the Hamlet working. In addition new regulations on banks were imposed, and a town credit union was made to spark lending again to citizens and spark the economy again. By 1955 all economic matters were privatized in the Cornwall Water Industry but banks were strictly regulated to this day. By the 1960s population continued to pick up again as the economy got better in the area as the Cornwall Council continued to take measures in helping out the area. The first ever public school for ages four to sixteen was created. Due to the political nature of the Hamlet, it was spearheaded at a local level and put to a referendum. At the time only one primary school existed, Baxter Primary School, since most children were home schooled or worked with their parents at the bay or in the marketplace. The Cornwall education referendum, 1966 created Cornwall Village School, then Cornwall Hamlet School, and raised property and income taxes to pay for it. Flooding in 1979 The 1979 Cornwall floods occured as east side of the dock was destroyed by series of floods which resulted in multiple ships being broken, a new dock need to be rebuilt and over 200,000 dollars in house and shop damage. By 1980 all damages were repayed by the Council in helping clean up the mess, and by 1982 the east side dock was rebuilt. The town square across the streets from the docks. West side of Cornwall Due to the creation of the school more people decided to move to the Hamlet to want a more quiet rural life. By 1990 population increased back to 400. The history of the town took a minor financial hit during 1994 when the Cornwall Council, which was one of the only active councils during the entire 1900s to allow for more streamlined and active government, decided to cut 10 education jobs because of the debt held by the town. A year later another referendum was held in the town, the Cornwall financial referendum, 1995 was approved to accept some austerity measures which raised taxes on all citizens and cut an addition bureaucracy jobs. Through the loss in education, population still was booming. During that time the local authority decided to protect Rider Mountain and the small forest around it. The protection, along with the federal and state governments, created a new agency and about 20 new jobs to protect the environment around the ocean and mountains. In 2000 a local census was taken and showed that Cornwall was now a Village. 572 people now lived in Cornwall and with a big celebration in the Cornwall Town Square many people from nearby settlements came to see the beauty of Cornwall and population greatly increased in the next couple of years. In 2010 when the Federal government took away all power from local authorities the strong support for the Council in the Village led to protests on the docks to keep the power of the Council. Since the Federal government took no action to took the council down, it continued with elections and power was still held in the council. Since the federal and state government no longer provided firefighters or policemen the Cornwall Police and Fire Authority was created to keep the peace in the Village. Today the Village continues with population growth and is soon near to reach Village status. Economy Edit Boat in Corwall A boat shown here resembles the economy of Cornwall which centers around the water. The economy of Cornwall is very interdependent on other states in Lovia and the economy in nearby nations such as the United States, in particular the states of California and Hawaii to buy their goods and fish. About 74% of the people in the Village are dependent on fishing, docking, or working. Another 16% work for the government in public education, bureaucracy, or policing. Another 10% work in local shops or for private companies within the Village. Demographics Edit Population has almost doubled in the last 20 years. About 7 in 10 people in Cornwall are Christian. The demographics of the Village have rarely changed over time throughout the history of Cornwall. During the beginning years of the settlement population was mostly made up of the Cornish settlers and those who helped build the settlement. During the beginning of the depression about 400 people lived in the Village which resulted in a rise in unemployment because as the Hamlet increased in size beforehand, it was decreasing now and didn't have jobs for the new people in the Hamlet. By 1945 the Hamlet reached 290 people but due to economic innovation and ideas, along with a raise in public sector spending, population would recover greatly over the next sixty years raising steadily. In 2000 the Hamlet became a Village when it reached 572 people. The Village now has over 900 people. The city has a strongly British and Cornish presence there still. While English is the official language, about 99% of the people speak it, about 18% of the people speak Cornish as a second or first language. Once in 1965 about 5% of the people spoke Bredish or Chinese, since then the population has moved away. According to the last census about 71% of the people in Cornwall believe in a God, all of them Christian. Of the entire population, 68% are some form of Lutheran, another 3% are Catholic. Another 20% identify as agnostic, stating they believe in some form of God. A small 9% are atheists believing in no God. Politics Edit Cornwall Council logo Cornwall Council logo The town has always been politically active throughout the history of the town. In 1920 the local Cornwall Council was created to have a government sector involved in the settlement and allow for devolved spending and regulations on the citizens in the town. The town has had four local political parties during the course of it's history. Essentially due to the laws in the City, only local parties may run in the Cornwall Council, a law passed in 1927 stating so. This was to not have larger parties pour large amounts of political capital and money into the town, instead elections would be free from corporate and trade union interest, each to a certain extent, and allow for more democratic elections. The Cornwall Council is made up of 15 councilors, four elected from single distircts (Northwest, Southwest, Northeast, Southeast), one settlementwide Council President, and the rest elected from Party List porportional representation. It is government on a parliamentary basis of the majority party controlling the Council. The Council President serves as a speaker of the Council, which also has a vote just also serving as a speaker for the body.  The Council has turned to a referendum five times during the history of Cornwall. The first was held in 1929 over the naming of the settlement in the Cornwall naming referendum, 1929. The people changed the name from "New Cornwall" to just "Cornwall" for economic and cultural reasons. The second came in 1966 in the Cornwall education referendum, 1966 which approved new measures to create a new trade and technical school in the state, along with a tax increase to pay for it. The next two came together in 1985 in the Cornwall roads referendum, 1985 which set a speed limit on motor vehicals within the settlement's limits, and the second on the limit of vehicals on the outer settlement limits. The most recent referendum occured to adopt some minor austerity measures during the Cornwall financial referendum, 1995. All referendums were approved, with more than 50% of the franchise voting, and 50% of the voters then approving it. Throughout the political history of Cornwall, for Parties have been founded and have since been able to stay afloat and reach representation from time to time during the course of the settlement. The three most dominant political parties are the Cornish Progressive Party, Conservatives and Liberal Future. Another political force the Moderate Party has been in power which supports docker and fishers rights while supporting centrist social and economic conditions. Map Edit Pacific Ocean Cornwall Lighthouse 13 Cornwall Avenue ferry port Cornwall Docks 2-4-6-8-10 Cornwall Avenue Cornwall Docks 11 Cornwall Avenue Cornwall Docks 12 Cornwall Avenue Cornwall Avenue Local Shop 1 Cornwall Avenue Local Diners, Famous Cornish Pasties and Cornish Chippy  3 Cornwall Avenue Baxter Primary School 5 Cornwall Avenue Marcus Villanova 7 Cornwall Avenue Cornwall Town Square    Home to Cornwall Council, Cornwall Village School, Oxford Credit Union, and the outside market place 9 Cornwall Avenue New Avenue Local Shops 1 New Avenue Local Shopping Market 2 New Avenue Fishing Shop 4 New Avenue Home Shop 6 New Avenue Marcel Cebara 8 New Avenue Vineyard Store 3 New Avenue Attlee Hospital 5 New Avenue Hot Dog House 7 New Avenue 9 New Avenue Krosses Books 10 New Avenue Cornwall Police and Fire Authority 11 New Avenue St. James Anglican Church 12 New Avenue Ad blocker interference detected!

dclm

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flan-26544709

Here is a premise: They are all busily battering at Mrs. Inglethorp's door. Here is a hypothesis: Mrs. Inglethorp's door is being battered by several people. Here are the options: OPTIONS: - yes; - it is not possible to tell; - no; Is it possible to conclude that if the premise is true, then so is the hypothesis? yes

flan

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pes2o-6937493

Semantic Structure of Verbs ‘Touch’ in Indonesian and Batak Toba Language This study discusses the semantic structures of the verbs “touch” in Indonesian and Batak Toba Language. This study applied the Natural Semantic Metalanguage theory by Wierzbicka. The data were collected through observation and interview methods. The findings are four parts of the verbs “touch” found in Indonesian and Batak Toba Language, they are: a) touch – feel; b) touch – press; c) touch – beat; d) touch – rub. The semantic structures of the verbs “touch” in Indonesian and BTL are mostly similar. However, there are three verbs which are different in the semantic structures, they are: meremas (mamisat) ‘squeeze’, menepuk (manompuk) ‘pat’ and mencubit (manggotil) ‘pinch’. The semantic structure differences in Indonesian and BTL occur because the two societies are distinctive and the different use of the language is diverse.

pes2o

{"added":"2020-01-09T09:14:32.222Z","created":"2020-01-06T00:00:00.000Z","id":"213377472","metadata":{"abstract":"This study discusses the semantic structures of the verbs \u201ctouch\u201d in Indonesian and Batak Toba Language. This study applied the Natural Semantic Metalanguage theory by Wierzbicka. The data were collected through observation and interview methods. The findings are four parts of the verbs \u201ctouch\u201d found in Indonesian and Batak Toba Language, they are: a) touch \u2013 feel; b) touch \u2013 press; c) touch \u2013 beat; d) touch \u2013 rub. The semantic structures of the verbs \u201ctouch\u201d in Indonesian and BTL are mostly similar. However, there are three verbs which are different in the semantic structures, they are: meremas (mamisat) \u2018squeeze\u2019, menepuk (manompuk) \u2018pat\u2019 and mencubit (manggotil) \u2018pinch\u2019. The semantic structure differences in Indonesian and BTL occur because the two societies are distinctive and the different use of the language is diverse.","abstract_count":131,"abstract_language":"en","abstract_perplexity":-16.912245041559856,"extfieldsofstudy":["Sociology"],"provenance":"pes2o_v2-0001.json.gz:3074962","s2fieldsofstudy":["Linguistics"],"sha1":"04ed487474eb8feb4c64cd0de071f07fa1fdae21","sources":["MergedPDFExtraction","Unpaywall","MAG","Crossref","Anansi"],"title":"Semantic Structure of Verbs \u2018Touch\u2019 in Indonesian and Batak Toba Language","title_count":11,"title_language":"en","title_perplexity":-16.43494849042714,"top_frequencies":[{"count":9,"token":"the"},{"count":8,"token":"and"},{"count":6,"token":"in"},{"count":5,"token":"of"},{"count":5,"token":"Indonesian"},{"count":5,"token":"are"},{"count":4,"token":"semantic"},{"count":4,"token":"verbs"},{"count":4,"token":"The"},{"count":4,"token":"touch"},{"count":4,"token":"\u2013"},{"count":3,"token":"Batak"},{"count":3,"token":"Toba"},{"count":3,"token":"\u201ctouch\u201d"},{"count":2,"token":"Semantic"},{"count":2,"token":"This"},{"count":2,"token":"study"},{"count":2,"token":"structures"},{"count":2,"token":"they"},{"count":2,"token":"are:"},{"count":2,"token":"BTL"},{"count":2,"token":"different"},{"count":1,"token":"Structure"},{"count":1,"token":"Verbs"},{"count":1,"token":"\u2018Touch\u2019"},{"count":1,"token":"Language"},{"count":1,"token":"discusses"},{"count":1,"token":"Language."},{"count":1,"token":"applied"},{"count":1,"token":"Natural"},{"count":1,"token":"Metalanguage"},{"count":1,"token":"theory"},{"count":1,"token":"by"},{"count":1,"token":"Wierzbicka."},{"count":1,"token":"data"},{"count":1,"token":"were"},{"count":1,"token":"collected"},{"count":1,"token":"through"},{"count":1,"token":"observation"},{"count":1,"token":"interview"},{"count":1,"token":"methods."},{"count":1,"token":"findings"},{"count":1,"token":"four"},{"count":1,"token":"parts"},{"count":1,"token":"found"},{"count":1,"token":"Language,"},{"count":1,"token":"a)"},{"count":1,"token":"feel;"},{"count":1,"token":"b)"},{"count":1,"token":"press;"},{"count":1,"token":"c)"},{"count":1,"token":"beat;"},{"count":1,"token":"d)"},{"count":1,"token":"rub."},{"count":1,"token":"mostly"},{"count":1,"token":"similar."},{"count":1,"token":"However,"},{"count":1,"token":"there"},{"count":1,"token":"three"},{"count":1,"token":"which"},{"count":1,"token":"structures,"},{"count":1,"token":"meremas"},{"count":1,"token":"(mamisat)"},{"count":1,"token":"\u2018squeeze\u2019,"},{"count":1,"token":"menepuk"},{"count":1,"token":"(manompuk)"},{"count":1,"token":"\u2018pat\u2019"},{"count":1,"token":"mencubit"},{"count":1,"token":"(manggotil)"},{"count":1,"token":"\u2018pinch\u2019."},{"count":1,"token":"structure"},{"count":1,"token":"differences"},{"count":1,"token":"occur"},{"count":1,"token":"because"},{"count":1,"token":"two"},{"count":1,"token":"societies"},{"count":1,"token":"distinctive"},{"count":1,"token":"use"},{"count":1,"token":"language"},{"count":1,"token":"is"},{"count":1,"token":"diverse."}],"year":2020},"source":"s2","version":"v3-fos"}

pes2o-14056117

The Open Court terpreter, and perhaps assisted with her ideas. It is probable that the Constitution so framed was the most thoroughly republican instrument ever framed. It has never appeared in English, but is printed in the works of Condorcet (Paris, 1805). It was offered to the French Convention in February 1793, but did not please the revolutionary "Mountain," which really desired no Constitution, but permanent revolutionism. Thus the document has attracted no study, but it well deserves the attention of those interested in political philosophy. I send you a translation of the Declaration of Rights. It impresses me as far surpassing any other instrument of that kind known in European or American history. "The end of all union of men in society being maintenance of their natural rights, civil and political, these rights should be the basis of the social compact :

pes2o

{"added":"2016-02-02T08:36:57.578Z","created":"2014-01-01T00:00:00.000Z","id":"12759144","metadata":{"abstract":"terpreter, and perhaps assisted with her ideas. It is probable that the Constitution so framed was the most thoroughly republican instrument ever framed. It has never appeared in English, but is printed in the works of Condorcet (Paris, 1805). It was offered to the French Convention in February 1793, but did not please the revolutionary \"Mountain,\" which really desired no Constitution, but permanent revolutionism. Thus the document has attracted no study, but it well deserves the attention of those interested in political philosophy. I send you a translation of the Declaration of Rights. It impresses me as far surpassing any other instrument of that kind known in European or American history. \"The end of all union of men in society being maintenance of their natural rights, civil and political, these rights should be the basis of the social compact :","abstract_count":140,"abstract_language":"en","abstract_perplexity":-13.596068220979138,"extfieldsofstudy":[],"provenance":"pes2o_v2-0003.json.gz:2440927","s2fieldsofstudy":["History"],"sha1":"df443b26f823d1b15cefad94dc1bce2f0757022c","sources":["ScienceParseMerged","Anansi","Adhoc","Grobid","MergedPDFExtraction","Crawler"],"title":"The Open Court","title_count":3,"title_language":"en","title_perplexity":-9.365897877257442,"top_frequencies":[{"count":10,"token":"the"},{"count":9,"token":"of"},{"count":6,"token":"in"},{"count":4,"token":"It"},{"count":4,"token":"but"},{"count":2,"token":"and"},{"count":2,"token":"is"},{"count":2,"token":"that"},{"count":2,"token":"was"},{"count":2,"token":"instrument"},{"count":2,"token":"has"},{"count":2,"token":"no"},{"count":1,"token":"The"},{"count":1,"token":"Open"},{"count":1,"token":"Court"},{"count":1,"token":"terpreter,"},{"count":1,"token":"perhaps"},{"count":1,"token":"assisted"},{"count":1,"token":"with"},{"count":1,"token":"her"},{"count":1,"token":"ideas."},{"count":1,"token":"probable"},{"count":1,"token":"Constitution"},{"count":1,"token":"so"},{"count":1,"token":"framed"},{"count":1,"token":"most"},{"count":1,"token":"thoroughly"},{"count":1,"token":"republican"},{"count":1,"token":"ever"},{"count":1,"token":"framed."},{"count":1,"token":"never"},{"count":1,"token":"appeared"},{"count":1,"token":"English,"},{"count":1,"token":"printed"},{"count":1,"token":"works"},{"count":1,"token":"Condorcet"},{"count":1,"token":"(Paris,"},{"count":1,"token":"1805)."},{"count":1,"token":"offered"},{"count":1,"token":"to"},{"count":1,"token":"French"},{"count":1,"token":"Convention"},{"count":1,"token":"February"},{"count":1,"token":"1793,"},{"count":1,"token":"did"},{"count":1,"token":"not"},{"count":1,"token":"please"},{"count":1,"token":"revolutionary"},{"count":1,"token":"\"Mountain,\""},{"count":1,"token":"which"},{"count":1,"token":"really"},{"count":1,"token":"desired"},{"count":1,"token":"Constitution,"},{"count":1,"token":"permanent"},{"count":1,"token":"revolutionism."},{"count":1,"token":"Thus"},{"count":1,"token":"document"},{"count":1,"token":"attracted"},{"count":1,"token":"study,"},{"count":1,"token":"it"},{"count":1,"token":"well"},{"count":1,"token":"deserves"},{"count":1,"token":"attention"},{"count":1,"token":"those"},{"count":1,"token":"interested"},{"count":1,"token":"political"},{"count":1,"token":"philosophy."},{"count":1,"token":"I"},{"count":1,"token":"send"},{"count":1,"token":"you"},{"count":1,"token":"a"},{"count":1,"token":"translation"},{"count":1,"token":"Declaration"},{"count":1,"token":"Rights."},{"count":1,"token":"impresses"},{"count":1,"token":"me"},{"count":1,"token":"as"},{"count":1,"token":"far"},{"count":1,"token":"surpassing"},{"count":1,"token":"any"},{"count":1,"token":"other"},{"count":1,"token":"kind"},{"count":1,"token":"known"},{"count":1,"token":"European"},{"count":1,"token":"or"},{"count":1,"token":"American"},{"count":1,"token":"history."},{"count":1,"token":"\"The"},{"count":1,"token":"end"},{"count":1,"token":"all"},{"count":1,"token":"union"},{"count":1,"token":"men"},{"count":1,"token":"society"},{"count":1,"token":"being"},{"count":1,"token":"maintenance"},{"count":1,"token":"their"},{"count":1,"token":"natural"},{"count":1,"token":"rights,"},{"count":1,"token":"civil"},{"count":1,"token":"political,"}],"year":2014},"source":"s2","version":"v3-fos"}

flan-3972568

input: Please answer the following: Generate a 5-star review (1 being lowest and 5 being highest) about an app with package com.watabou.pixeldungeon. ++++++++++ output: Very challenging took me 2 weeks constant playing to finish and when finally made it out you feel so rewarded occasionally frustrating but nevertheless ingenious mechanics and unique tweaks. I love it! input: Please answer the following: Generate a 5-star review (1 being lowest and 5 being highest) about an app with package com.google.android.marvin.talkback. ++++++++++ output: Good input: Please answer the following: Generate a 4-star review (1 being lowest and 5 being highest) about an app with package com.google.android.gms. ++++++++++ output: Seper Yo input: Please answer the following: Generate a 5-star review (1 being lowest and 5 being highest) about an app with package org.telegram.messenger. ++++++++++ output: Hayrullah Ganizade

flan

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dclm-416417984

San José, Costa Rica, since 1956 United Nations President Solís tells world leaders Costa Rica is a model of sustainable development Costa Rica President Luis Guillermo Solís told world leaders gathered in New York this past weekend that his country’s sustainable development model is worthy of emulation. Solís touted Costa Rica’s green path in a speech Sunday at the United Nations’ Post-2015 Development Agenda Summit. He urged other nations to realign their spending away from militarization and towards peace efforts and the 2030 Agenda Development Goals adopted by the U.N. Solís said that Costa Rica is a country with sustainable development “in its DNA”: “Today we say that it is possible and we urge the creation of other societies that are peaceful, just, and inclusive, free of fear and violence. The 2030 Agenda is clear: sustainable development is not possible without peace, nor can peace exist without sustainable development,” Solís said, according to a transcript made available by Casa Presidencial. The president took encouragement from Pope Francis’ speech to the U.N. Friday, saying that the pontiff described Costa Rica when he spoke about caring for the planet, sustainable development and peace. “This is a pope thinking about the Costa Rican model,” Solís said in a statement after the speech Friday. The president highlighted Costa Rica’s decision to abolish its armed forces in 1948 and its focus on clean energy — including the 213 days so far this year that Costa Rica has been able to generate electricity using only renewable sources — and repeated the country’s pledge to become carbon neutral by 2021. The Costa Rican leader called on the seven permanent member states of the U.N. Security Council to lead by example and reduce military spending in favor of projects that would help end extreme poverty. “There is no better formula for security in their own countries than to guarantee sustainable development for the whole world,” Solís said. During the weekend, Solís also participated in the Beijing + 20 meeting on women’s rights and empowerment. The president called for an end to sex discrimination in all levels of society and pledged that Costa Rica would establish a quality seal to certify gender equality in businesses and institutions, among other goals. Solís also met briefly with the Arab League Secretary-General Nabil Elaraby to discuss the Syrian refugee crisis, the Islamic State group, and possible future investment opportunities in Costa Rica from the Middle East. Solís addresses the U.N. General Assembly Wednesday morning for the second time in his presidency. Contact Zach Dyer at Log in to comment So if Costa Rica was totally green with the grid for so long, why were the oil burning plants still running? Answer; we sell electricity to other countries on the SEPAC power line. How green is that? Why can I not drive my car one day a week in San Jose? 0 0 Fernando Gerdano Did he tell them that we still send all our poo to the rivers? 0 0 Rick Drigo Right on Mark, running out of OPM is the problem plus trying to be politically correct. Courting the Arabs will bring disaster to CR, and he knows it. Gutless poli-ticks are just like the spineless husband who knows what his wife is presurring him to do is wrong but he fears her more now tan he fears the future consequences. 0 0 Mark Kahle With Gender/Sex equality he should begin by abolishing the multiple government offices that aid women but not men… starting with PANI (read their mandate/mission statement) and then cleaning the constitution of the extreme gender/sexual bias contained there-in. As to banning the military as a benefit… yep, all you have to do is find a country like the US and get them to sign an agreement that Costa Ricans can sit on their hands should armed conflict break out here while they spill their blood for you…. Oh, wait, they did do just that. Now he wants to open Costa Rica to the very people that are causing the majority of the worlds’ problems…Arabs. All of the above makes perfect sense if you are a Socialist that is running out of other peoples’ money to spend. I could go on and on but it would fall on deaf ears. 0 0

dclm

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flan-9890197

input question: Write a sentence not in English. output answer: Als fünffacher Vater und Landwirt auf einem ehemals königlichen 400-Hektar-Gut blieben Ott nur die Abende und Sonntage, um sich zu Hause durch ein „kreatives Chaos“ an Dokumenten und Unterlagen zu kämpfen und dieses vergessene Kapitel der Vergangenheit seiner Stadt zu dokumentieren. Das Ergebnis: Buttenhausen hat inzwischen ein von Ott aufgebautes Jüdisches Museum, wo der 81-Jährige bis heute Führungen macht (für Schulklassen ebenso wie z. input question: Write a sentence not in English. output answer: Daneben ist das spontane Wachsen von diesen Baumsorten auch möglich. input question: Write a sentence not in English. output answer: Das Risiko der Herstellung und des Inverkehrbringens von gefälschtem Eurogeld stellt eine große Belastung in der Anfangszeit der Benutzung der Einheitswährung, d. h. in den Jahren unmittelbar nach Einführung des Eurobargelds am 1. Januar nächsten Jahres, dar, denn in diesem ausschlaggebenden Zeitraum ist das Vertrauen der Bürger von grundlegender Bedeutung. input question: Write a sentence not in English. output answer: Es eröffnen sich unendliche Freizeitmöglichkeiten: am und auf dem nahe gelegenen Rhein, auf dem Reiat und in der Vulkanlandschaft Hegau mit ihren alten Burgen.

flan

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dclm-413507761

Best Answer A Satellite Television system has many benefits and is ideal for many types of people. Some of the advantages are: * People in remote areas can get satellite television even if they are not able to receive cable services. * The picture provided by satellite is far sharper than either cable or off air broadcast. * People who are the technical types and like fixing their own things will love satellite television. * It provides digital information and text services. * Satellite television gives you access to channels and programs that can never be offered through cable. * It gives you news coverage which is live and unedited so you don User Avatar Wiki User 2004-12-10 17:20:16 This answer is: User Avatar Add your answer: Earn +5 pts Q: What are the advantages of a satellite television system? Write your answer... Related Questions What are the main advantages of using a satellite TV system? There are two main advantages to satellite TV. First, a customer can get TV in the relative middle of nowhere. Second, it generally has a better picture quality than other TV services. Whats are the advantages of satellite communication over the other communication system'? advantages of satellite What are the advantages of satellite television over cable? Satellite TV normally has a wider variety of programming options. You also will normally spend less per month for satellite tv. What are some advantages and disadvantages of cable and satellite tv? Cable and satellite TV can go out at anytime and have connection problems sometimes. What are the advantages of satellite television compared to regular cable? The only advantage that satellite internet has over cable, is that in certain locations where cable is unavailable, usually satellite will provide television services. What are the pros and cons to using a satellite television system in an urban environment? You can get better reception with a satellite television system. You may also deal with a lot of interference in an urban environment. What are some of the advantages and disadvantages between cable and satellite TV? Cable TV is more reliant and less costly. On the other hand, satellite often offers more channels. Best serice amd best price in walnut creek ca direct tv or dish network satellite system for rv? The best series with the best price as well is Satellite system for TV. Is satellite television better than cable? Satellite TV offers a lot of advantages to cable, especially for those in remote rural areas without cable access. Plus, there is less service down-time with satellite technology, and you can get equipment to service multiple sets. There are advantages to both. Usually one can get more channels for the price with satellite, but reception can be spottier in bad weather. Contracts and fees tend to be more stringent with satellite. What is the best TV satellite system for a motorhome? It depends on what kind of motorhome and when you want to watch Dish TV. If you will be mobile and wanting television, you will need a self adjusting satellite dish; there are also stationary satellite dishes available. As far as a satellite system, I prefer Dish TV because of the price, channel selection and technology. Dish Network also has a affordable portable satellite dish that does not attach to your motor-home called the Dish Tailgater. What are the advantages of satellite when it comes to cable vs satellite? Satellite television has some advantages over cable because it is usually cheaper in cost. The activation fees are something you do not need to pay. It also offers more channels for sports and music than cable would. How do you hookup a second TV with a dish satellite system? you will be needing a duo standard receiver which features two satellite tuners What should I know before purchasing a satellite? Did you mean a stellite TV, phone or navigation system? The answer will depend on what type of satellite service you are looking for. If its satellite TV id first make sure you can get service in your area. What are the advantages of having satellite tv? One advantage of satellite television is that more channels are available than on regular cable. Some say that the picture is more clear and that it can be less expensive than digital cable. Will satellite tv be effected by everything going digital on Feb. 17, 2009? DTV transition will not affect satellite TV subscribers who receive their local TV stations through their satellite dishes. Satellite TV service is a digital service and all satellite subscribers must have a set-top box connected to their TVs to receive the satellite-delivered programming. you should check with your provider to find out if you receive a local TV station package through your satellite dish just to make sure. Your satellite TV system may be using digital technology as a more efficient way of delivering analog programming to you but if you have an analog television set, then you are probably not getting digital. Bottom line&#65533; your satellite tv service might be fine but your tv will not be. Does fog affect satellite TV? No fog does not affect Satellite TV. How satellite works and how is satellite? Satellite TV is delivered by the means of communication satellite and received by a satellite dish and set-top box connected to the television set. How do you set up a tv with satellite to a wii game system? dear people i need help setting the wii system to a salite tv so i can play it What is the advantages and disadvantages of satellite telecommunication system? 1) The coverage area of a satellite greatly exceeds.2) Transmission cost of a satellite is independent of the distance from the center of the coverage area. 3) Satellite to satellite communication is very precise. 4) Higher bandwidths are available for use. How do you hookup a Dish TV satellite receiver to VOIP phone system? The best way to hookup a satellite receiver to a VoIP phone system is simply contacting your service provider and ask them for assistance. What is the best satellite television system? AT&amp;T, Dish Network and Directv all offer great satellite television systems. AT&amp;T is the best because you can bundle it with your home and cell phone, as well as internet. When did people get to watch Satellite TV? 1963 by using a geosynchronous communication satellite called the Syncom Watch satellilte tv with satellite tv tuner like TBS TV Tuners What is satellite receiver? A satellite receievr, is a tv receiver, which connects to the satellite anntena, than to your tv, and decodes the information coming from the satellite signal into video and audio signal, so you can watch tv channels. Connect DVD player with satellite to tv? how to connect dvd player to satellite tv? What is the motto of Dream Satellite TV? The motto of Dream Satellite TV is 'Reaching You, Touching You'.

dclm

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pes2o-28253277

The Heat is On: Thermal Sensing and Newsgathering – A Look at the Legal Implications of Modern Newsgathering Thermal imaging technology, which was once used primarily by the military, has made its way into the civilian world. Journalists have begun making use of the technology, and, as that use becomes more prevalent, concerns about legal issues also arise. This article, relying on tort privacy cases, Fourth Amendment case law, and theoretical conceptualizations of privacy, provides an in-depth examination of the legal implications surrounding the use of thermal imaging devices for newsgathering.

pes2o

{"added":"2019-05-11T13:06:36.701Z","created":"2018-01-02T00:00:00.000Z","id":"148838879","metadata":{"abstract":"Thermal imaging technology, which was once used primarily by the military, has made its way into the civilian world. Journalists have begun making use of the technology, and, as that use becomes more prevalent, concerns about legal issues also arise. This article, relying on tort privacy cases, Fourth Amendment case law, and theoretical conceptualizations of privacy, provides an in-depth examination of the legal implications surrounding the use of thermal imaging devices for newsgathering.","abstract_count":73,"abstract_language":"en","abstract_perplexity":-14.06824807035238,"extfieldsofstudy":["Political Science"],"provenance":"pes2o_v2-0007.json.gz:1146681","s2fieldsofstudy":["Law"],"sha1":"fc8e1aa4044125460e595b3a6ea19f901fd56594","sources":["MAG","Unpaywall","TaylorAndFrancis","MergedPDFExtraction"],"title":"The Heat is On: Thermal Sensing and Newsgathering \u2013 A Look at the Legal Implications of Modern Newsgathering","title_count":18,"title_language":"en","title_perplexity":-13.402363639325316,"top_frequencies":[{"count":6,"token":"the"},{"count":5,"token":"of"},{"count":3,"token":"use"},{"count":2,"token":"Thermal"},{"count":2,"token":"and"},{"count":2,"token":"Newsgathering"},{"count":2,"token":"imaging"},{"count":2,"token":"technology,"},{"count":2,"token":"legal"},{"count":1,"token":"The"},{"count":1,"token":"Heat"},{"count":1,"token":"is"},{"count":1,"token":"On:"},{"count":1,"token":"Sensing"},{"count":1,"token":"\u2013"},{"count":1,"token":"A"},{"count":1,"token":"Look"},{"count":1,"token":"at"},{"count":1,"token":"Legal"},{"count":1,"token":"Implications"},{"count":1,"token":"Modern"},{"count":1,"token":"which"},{"count":1,"token":"was"},{"count":1,"token":"once"},{"count":1,"token":"used"},{"count":1,"token":"primarily"},{"count":1,"token":"by"},{"count":1,"token":"military,"},{"count":1,"token":"has"},{"count":1,"token":"made"},{"count":1,"token":"its"},{"count":1,"token":"way"},{"count":1,"token":"into"},{"count":1,"token":"civilian"},{"count":1,"token":"world."},{"count":1,"token":"Journalists"},{"count":1,"token":"have"},{"count":1,"token":"begun"},{"count":1,"token":"making"},{"count":1,"token":"and,"},{"count":1,"token":"as"},{"count":1,"token":"that"},{"count":1,"token":"becomes"},{"count":1,"token":"more"},{"count":1,"token":"prevalent,"},{"count":1,"token":"concerns"},{"count":1,"token":"about"},{"count":1,"token":"issues"},{"count":1,"token":"also"},{"count":1,"token":"arise."},{"count":1,"token":"This"},{"count":1,"token":"article,"},{"count":1,"token":"relying"},{"count":1,"token":"on"},{"count":1,"token":"tort"},{"count":1,"token":"privacy"},{"count":1,"token":"cases,"},{"count":1,"token":"Fourth"},{"count":1,"token":"Amendment"},{"count":1,"token":"case"},{"count":1,"token":"law,"},{"count":1,"token":"theoretical"},{"count":1,"token":"conceptualizations"},{"count":1,"token":"privacy,"},{"count":1,"token":"provides"},{"count":1,"token":"an"},{"count":1,"token":"in-depth"},{"count":1,"token":"examination"},{"count":1,"token":"implications"},{"count":1,"token":"surrounding"},{"count":1,"token":"thermal"},{"count":1,"token":"devices"},{"count":1,"token":"for"},{"count":1,"token":"newsgathering."}],"year":2018},"source":"s2","version":"v3-fos"}

pes2o-15788311

The effects of music listening on the management of pain in primary dysmenorrhea: A randomized controlled clinical trial ABSTRACT Introduction: This study aims to explore the effects of music listening, compared to silence, on pain management in primary dysmenorrhea (PD). Method: A researcher-blinded randomized controlled clinical trial was conducted from September 2017 to April 2018 at the Universidad del Rosario (Bogota, Colombia). Women with PD aged between 18 years and 26 years old were included. The intervention was provided during the first 12 hours of menses. Participants were instructed to avoid analgesics until the intervention. The music group (n = 29) listened to a C major musical composition with a tempo of 60 beats per minute and no percussion nor lyrics. Silence was used for the control group (n = 23). Both interventions lasted 29ʹ32” and participants wore headphones in both groups. Pain (using a 10-cm visual analogue scale), anxiety (using the Zung scale), and the expressed desire to use other analgesic treatments were evaluated immediately after and 3–6 hours after the intervention. The primary outcome was change in pain from pre to post intervention measurements. Results: Homogeneity between groups was reached. Adjusted mean pain scores after the interventions were significantly lower (p = 0.006; R 2 = 0.545) in the music group (adjusted mean 3.13) than the silence group (adjusted mean 4.56). Logistic regression showed that music group was more likely to reduce analgesic use after the intervention (OR 5.4, 95% CI 1.4–21, R 2 = 0.28). Discussion: Music listening during the first 12 hours of menses significantly reduced pain and the need for analgesics in PD compared to silence. Trial registration: NCT03593850; ClinicalTrials.gov

pes2o

{"added":"2020-06-18T09:05:43.930Z","created":"2020-06-16T00:00:00.000Z","id":"222803605","metadata":{"abstract":"ABSTRACT Introduction: This study aims to explore the effects of music listening, compared to silence, on pain management in primary dysmenorrhea (PD). Method: A researcher-blinded randomized controlled clinical trial was conducted from September 2017 to April 2018 at the Universidad del Rosario (Bogota, Colombia). Women with PD aged between 18 years and 26 years old were included. The intervention was provided during the first 12 hours of menses. Participants were instructed to avoid analgesics until the intervention. The music group (n = 29) listened to a C major musical composition with a tempo of 60 beats per minute and no percussion nor lyrics. Silence was used for the control group (n = 23). Both interventions lasted 29\u02b932\u201d and participants wore headphones in both groups. Pain (using a 10-cm visual analogue scale), anxiety (using the Zung scale), and the expressed desire to use other analgesic treatments were evaluated immediately after and 3\u20136 hours after the intervention. The primary outcome was change in pain from pre to post intervention measurements. Results: Homogeneity between groups was reached. Adjusted mean pain scores after the interventions were significantly lower (p = 0.006; R 2 = 0.545) in the music group (adjusted mean 3.13) than the silence group (adjusted mean 4.56). Logistic regression showed that music group was more likely to reduce analgesic use after the intervention (OR 5.4, 95% CI 1.4\u201321, R 2 = 0.28). Discussion: Music listening during the first 12 hours of menses significantly reduced pain and the need for analgesics in PD compared to silence. Trial registration: NCT03593850; ClinicalTrials.gov","abstract_count":257,"abstract_language":"en","abstract_perplexity":-16.65951965022267,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0004.json.gz:301704","s2fieldsofstudy":["Medicine","Psychology"],"sha1":"a85891a4b72d727bcda2781539144b1646ece5d0","sources":["Crossref","Unpaywall","TaylorAndFrancis","MAG"],"title":"The effects of music listening on the management of pain in primary dysmenorrhea: A randomized controlled clinical trial","title_count":18,"title_language":"en","title_perplexity":-11.985600681303335,"top_frequencies":[{"count":15,"token":"the"},{"count":9,"token":"to"},{"count":6,"token":"of"},{"count":6,"token":"in"},{"count":6,"token":"was"},{"count":6,"token":"and"},{"count":5,"token":"music"},{"count":5,"token":"pain"},{"count":5,"token":"group"},{"count":5,"token":"="},{"count":4,"token":"The"},{"count":4,"token":"were"},{"count":4,"token":"after"},{"count":3,"token":"primary"},{"count":3,"token":"intervention"},{"count":3,"token":"hours"},{"count":3,"token":"a"},{"count":3,"token":"mean"},{"count":2,"token":"effects"},{"count":2,"token":"listening"},{"count":2,"token":"on"},{"count":2,"token":"management"},{"count":2,"token":"A"},{"count":2,"token":"randomized"},{"count":2,"token":"controlled"},{"count":2,"token":"clinical"},{"count":2,"token":"trial"},{"count":2,"token":"compared"},{"count":2,"token":"from"},{"count":2,"token":"with"},{"count":2,"token":"PD"},{"count":2,"token":"between"},{"count":2,"token":"years"},{"count":2,"token":"during"},{"count":2,"token":"first"},{"count":2,"token":"12"},{"count":2,"token":"analgesics"},{"count":2,"token":"intervention."},{"count":2,"token":"(n"},{"count":2,"token":"for"},{"count":2,"token":"interventions"},{"count":2,"token":"(using"},{"count":2,"token":"scale),"},{"count":2,"token":"use"},{"count":2,"token":"analgesic"},{"count":2,"token":"significantly"},{"count":2,"token":"R"},{"count":2,"token":"2"},{"count":2,"token":"(adjusted"},{"count":1,"token":"dysmenorrhea:"},{"count":1,"token":"ABSTRACT"},{"count":1,"token":"Introduction:"},{"count":1,"token":"This"},{"count":1,"token":"study"},{"count":1,"token":"aims"},{"count":1,"token":"explore"},{"count":1,"token":"listening,"},{"count":1,"token":"silence,"},{"count":1,"token":"dysmenorrhea"},{"count":1,"token":"(PD)."},{"count":1,"token":"Method:"},{"count":1,"token":"researcher-blinded"},{"count":1,"token":"conducted"},{"count":1,"token":"September"},{"count":1,"token":"2017"},{"count":1,"token":"April"},{"count":1,"token":"2018"},{"count":1,"token":"at"},{"count":1,"token":"Universidad"},{"count":1,"token":"del"},{"count":1,"token":"Rosario"},{"count":1,"token":"(Bogota,"},{"count":1,"token":"Colombia)."},{"count":1,"token":"Women"},{"count":1,"token":"aged"},{"count":1,"token":"18"},{"count":1,"token":"26"},{"count":1,"token":"old"},{"count":1,"token":"included."},{"count":1,"token":"provided"},{"count":1,"token":"menses."},{"count":1,"token":"Participants"},{"count":1,"token":"instructed"},{"count":1,"token":"avoid"},{"count":1,"token":"until"},{"count":1,"token":"29)"},{"count":1,"token":"listened"},{"count":1,"token":"C"},{"count":1,"token":"major"},{"count":1,"token":"musical"},{"count":1,"token":"composition"},{"count":1,"token":"tempo"},{"count":1,"token":"60"},{"count":1,"token":"beats"},{"count":1,"token":"per"},{"count":1,"token":"minute"},{"count":1,"token":"no"},{"count":1,"token":"percussion"},{"count":1,"token":"nor"},{"count":1,"token":"lyrics."}],"year":2020},"source":"s2","version":"v3-fos"}

pes2o-22834378

Pixel architectures in a HV-CMOS process for the ATLAS inner detector upgrade In this paper, design details and simulation results of new pixel architectures designed in LFoundry 150 nm high voltage CMOS process in the framework of the ATLAS high luminosity inner detector upgrade are presented. These pixels can be connected to the FE-I4 readout chip via bump bonding or glue and some of them can also be tested without a readout chip. Negative high voltage is applied to the high resistivity (> 2 kΩ .cm) substrate in order to deplete the deep n-well charge collection diode, ensuring good charge collection and radiation tolerance. In these pixels, the front-end has been implemented inside the diode using both NMOS and PMOS transistors. The pixel pitch is 50 μm × 250 μm for all pixels. These pixels have been implemented in a demonstrator chip called LFCPIX.

pes2o

{"added":"2019-04-15T13:08:31.769Z","created":"2016-12-22T00:00:00.000Z","id":"113697777","metadata":{"abstract":"In this paper, design details and simulation results of new pixel architectures designed in LFoundry 150 nm high voltage CMOS process in the framework of the ATLAS high luminosity inner detector upgrade are presented. These pixels can be connected to the FE-I4 readout chip via bump bonding or glue and some of them can also be tested without a readout chip. Negative high voltage is applied to the high resistivity (> 2 k\u03a9 .cm) substrate in order to deplete the deep n-well charge collection diode, ensuring good charge collection and radiation tolerance. In these pixels, the front-end has been implemented inside the diode using both NMOS and PMOS transistors. The pixel pitch is 50 \u03bcm \u00d7 250 \u03bcm for all pixels. These pixels have been implemented in a demonstrator chip called LFCPIX.","abstract_count":132,"abstract_language":"en","abstract_perplexity":-15.001577634096355,"extfieldsofstudy":["Physics","Materials Science"],"provenance":"pes2o_v2-0005.json.gz:3471643","s2fieldsofstudy":["Physics"],"sha1":"3f2b8a7512311ae2621ec176402adfcde5dfb583","sources":["ScienceParsePlus","IOP","MergedPDFExtraction","Unpaywall","MAG"],"title":"Pixel architectures in a HV-CMOS process for the ATLAS inner detector upgrade","title_count":12,"title_language":"en","title_perplexity":-13.941355261278751,"top_frequencies":[{"count":8,"token":"the"},{"count":5,"token":"in"},{"count":4,"token":"and"},{"count":4,"token":"high"},{"count":3,"token":"a"},{"count":3,"token":"of"},{"count":3,"token":"to"},{"count":2,"token":"architectures"},{"count":2,"token":"process"},{"count":2,"token":"for"},{"count":2,"token":"ATLAS"},{"count":2,"token":"inner"},{"count":2,"token":"detector"},{"count":2,"token":"upgrade"},{"count":2,"token":"In"},{"count":2,"token":"pixel"},{"count":2,"token":"voltage"},{"count":2,"token":"These"},{"count":2,"token":"pixels"},{"count":2,"token":"can"},{"count":2,"token":"be"},{"count":2,"token":"readout"},{"count":2,"token":"chip"},{"count":2,"token":"is"},{"count":2,"token":"charge"},{"count":2,"token":"collection"},{"count":2,"token":"been"},{"count":2,"token":"implemented"},{"count":2,"token":"\u03bcm"},{"count":1,"token":"Pixel"},{"count":1,"token":"HV-CMOS"},{"count":1,"token":"this"},{"count":1,"token":"paper,"},{"count":1,"token":"design"},{"count":1,"token":"details"},{"count":1,"token":"simulation"},{"count":1,"token":"results"},{"count":1,"token":"new"},{"count":1,"token":"designed"},{"count":1,"token":"LFoundry"},{"count":1,"token":"150"},{"count":1,"token":"nm"},{"count":1,"token":"CMOS"},{"count":1,"token":"framework"},{"count":1,"token":"luminosity"},{"count":1,"token":"are"},{"count":1,"token":"presented."},{"count":1,"token":"connected"},{"count":1,"token":"FE-I4"},{"count":1,"token":"via"},{"count":1,"token":"bump"},{"count":1,"token":"bonding"},{"count":1,"token":"or"},{"count":1,"token":"glue"},{"count":1,"token":"some"},{"count":1,"token":"them"},{"count":1,"token":"also"},{"count":1,"token":"tested"},{"count":1,"token":"without"},{"count":1,"token":"chip."},{"count":1,"token":"Negative"},{"count":1,"token":"applied"},{"count":1,"token":"resistivity"},{"count":1,"token":"(>"},{"count":1,"token":"2"},{"count":1,"token":"k\u03a9"},{"count":1,"token":".cm)"},{"count":1,"token":"substrate"},{"count":1,"token":"order"},{"count":1,"token":"deplete"},{"count":1,"token":"deep"},{"count":1,"token":"n-well"},{"count":1,"token":"diode,"},{"count":1,"token":"ensuring"},{"count":1,"token":"good"},{"count":1,"token":"radiation"},{"count":1,"token":"tolerance."},{"count":1,"token":"these"},{"count":1,"token":"pixels,"},{"count":1,"token":"front-end"},{"count":1,"token":"has"},{"count":1,"token":"inside"},{"count":1,"token":"diode"},{"count":1,"token":"using"},{"count":1,"token":"both"},{"count":1,"token":"NMOS"},{"count":1,"token":"PMOS"},{"count":1,"token":"transistors."},{"count":1,"token":"The"},{"count":1,"token":"pitch"},{"count":1,"token":"50"},{"count":1,"token":"\u00d7"},{"count":1,"token":"250"},{"count":1,"token":"all"},{"count":1,"token":"pixels."},{"count":1,"token":"have"},{"count":1,"token":"demonstrator"},{"count":1,"token":"called"},{"count":1,"token":"LFCPIX."}],"year":2016},"source":"s2","version":"v3-fos"}

pes2o-5524484

Benign Skin Adenexal Tumor vs. Hemangioma: Diagnostic Pitfall Due to Cytologic Sampling Error Undifferentiated malignant sex cord stromal tumor (MSCST) is a subtype of sex cord stromal tumors, which arise from specialized sex cord and gonadal stromal cells. It is a rare neoplasm and is the least common form of sex cord stromal tumor. There have been only a few cases reported in the literature, most with histopathologic descriptions. We would like to report a case of undifferentiated malignant sex cord stromal tumor metastatic to an inguinal lymph node diagnosed by fine needle aspiration biopsy (FNAB). A 58-year-old man was diagnosed with undifferentiated malignant sex cord stromal tumor after right orchiectomy and also had retroperitoneal lymph node metastasis a few months later. He later presented with an enlarged left inguinal lymph node. Superficial FNA of the lymph node was performed using a 21-gauge needle. The smears were stained by Diff-Quik and Papanicolaou stains. They were cellular and showed numerous predominantly single tumor cells. A few tumor cells were in small clusters. The cells were large, polygonal and slightly spindle shaped and contained abundant granular cytoplasm (Figures 1 and 2). Cellular and nuclear pleomorphism was prominent. Few multinucleated tumor cells were noted. Some of the nuclei were eccentrically placed and had 1 or 2 prominent nucleoli. Chromatin pattern was either vesicular or clumped. Some nuclei contained large pseudoinclusions (Figure 2). Mitoses were difficult to appreciate on cytologic smears. Histology of the right orchiectomy was reviewed. It showed a spectrum of patterns, including tubules, trabeculae, nests and rare solid sheets of tumor cells. Most of the tumor cells were round to oval to spindle shaped, with abundant finely granular cytoplasm. The nuclei were round to oval with 1 or 2 small to moderately sized nucleoli (Figure 3). Mitoses were seen at up to 3 per 10 high power fields. Vascular invasion and tumor necrosis were present. The tumor had infiltrative borders with extension to the rete testis, right epididymis, spermatic cord and tunica vaginalis. Previous reports suggest that it is difficult to predict benign or malignant behavior of undifferentiated MSCSTs, except for those with overt metastases or gross local invasion.1,2 However, the presence of cellular pleomorphism, high mitotic activity, infiltrative borders, lymphovascular invasion and tumor necrosis should support a diagnosis of malignancy.3 Our case demonstrates how these features helped to confirm the malignant nature of this tumor before any evidence of metastases was determined. Cytomorphology of the tumor on FNAB smears and histology was similar. Immunohistochemical study of both FNAB and surgical specimen showed LETTERS TO THE EDITORS

pes2o

{"added":"2018-04-03T00:41:57.434Z","created":"2008-05-01T00:00:00.000Z","id":"3342881","metadata":{"abstract":"Undifferentiated malignant sex cord stromal tumor (MSCST) is a subtype of sex cord stromal tumors, which arise from specialized sex cord and gonadal stromal cells. It is a rare neoplasm and is the least common form of sex cord stromal tumor. There have been only a few cases reported in the literature, most with histopathologic descriptions. We would like to report a case of undifferentiated malignant sex cord stromal tumor metastatic to an inguinal lymph node diagnosed by fine needle aspiration biopsy (FNAB). A 58-year-old man was diagnosed with undifferentiated malignant sex cord stromal tumor after right orchiectomy and also had retroperitoneal lymph node metastasis a few months later. He later presented with an enlarged left inguinal lymph node. Superficial FNA of the lymph node was performed using a 21-gauge needle. The smears were stained by Diff-Quik and Papanicolaou stains. They were cellular and showed numerous predominantly single tumor cells. A few tumor cells were in small clusters. The cells were large, polygonal and slightly spindle shaped and contained abundant granular cytoplasm (Figures 1 and 2). Cellular and nuclear pleomorphism was prominent. Few multinucleated tumor cells were noted. Some of the nuclei were eccentrically placed and had 1 or 2 prominent nucleoli. Chromatin pattern was either vesicular or clumped. Some nuclei contained large pseudoinclusions (Figure 2). Mitoses were difficult to appreciate on cytologic smears. Histology of the right orchiectomy was reviewed. It showed a spectrum of patterns, including tubules, trabeculae, nests and rare solid sheets of tumor cells. Most of the tumor cells were round to oval to spindle shaped, with abundant finely granular cytoplasm. The nuclei were round to oval with 1 or 2 small to moderately sized nucleoli (Figure 3). Mitoses were seen at up to 3 per 10 high power fields. Vascular invasion and tumor necrosis were present. The tumor had infiltrative borders with extension to the rete testis, right epididymis, spermatic cord and tunica vaginalis. Previous reports suggest that it is difficult to predict benign or malignant behavior of undifferentiated MSCSTs, except for those with overt metastases or gross local invasion.1,2 However, the presence of cellular pleomorphism, high mitotic activity, infiltrative borders, lymphovascular invasion and tumor necrosis should support a diagnosis of malignancy.3 Our case demonstrates how these features helped to confirm the malignant nature of this tumor before any evidence of metastases was determined. Cytomorphology of the tumor on FNAB smears and histology was similar. Immunohistochemical study of both FNAB and surgical specimen showed LETTERS TO THE EDITORS","abstract_count":413,"abstract_language":"en","abstract_perplexity":-15.820650440102638,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0001.json.gz:1661953","s2fieldsofstudy":["Medicine"],"sha1":"0bf635e00e2f0728fd66b4ba99a74cf1e939d8f4","sources":["Medline","ScienceParseMerged","Karger","MAG","Unpaywall"],"title":"Benign Skin Adenexal Tumor vs. Hemangioma: Diagnostic Pitfall Due to Cytologic Sampling Error","title_count":13,"title_language":"uz","title_perplexity":-18.66016516129578,"top_frequencies":[{"count":16,"token":"of"},{"count":16,"token":"and"},{"count":13,"token":"tumor"},{"count":12,"token":"to"},{"count":11,"token":"were"},{"count":10,"token":"the"},{"count":8,"token":"a"},{"count":7,"token":"cord"},{"count":7,"token":"with"},{"count":7,"token":"was"},{"count":6,"token":"sex"},{"count":6,"token":"stromal"},{"count":5,"token":"malignant"},{"count":5,"token":"or"},{"count":4,"token":"is"},{"count":4,"token":"lymph"},{"count":4,"token":"The"},{"count":4,"token":"cells"},{"count":3,"token":"cells."},{"count":3,"token":"few"},{"count":3,"token":"undifferentiated"},{"count":3,"token":"node"},{"count":3,"token":"right"},{"count":3,"token":"had"},{"count":3,"token":"showed"},{"count":3,"token":"1"},{"count":3,"token":"nuclei"},{"count":2,"token":"It"},{"count":2,"token":"rare"},{"count":2,"token":"in"},{"count":2,"token":"case"},{"count":2,"token":"an"},{"count":2,"token":"inguinal"},{"count":2,"token":"diagnosed"},{"count":2,"token":"by"},{"count":2,"token":"A"},{"count":2,"token":"orchiectomy"},{"count":2,"token":"smears"},{"count":2,"token":"cellular"},{"count":2,"token":"small"},{"count":2,"token":"spindle"},{"count":2,"token":"contained"},{"count":2,"token":"abundant"},{"count":2,"token":"granular"},{"count":2,"token":"2)."},{"count":2,"token":"Some"},{"count":2,"token":"2"},{"count":2,"token":"(Figure"},{"count":2,"token":"Mitoses"},{"count":2,"token":"difficult"},{"count":2,"token":"on"},{"count":2,"token":"round"},{"count":2,"token":"oval"},{"count":2,"token":"high"},{"count":2,"token":"invasion"},{"count":2,"token":"necrosis"},{"count":2,"token":"infiltrative"},{"count":2,"token":"metastases"},{"count":2,"token":"FNAB"},{"count":1,"token":"Benign"},{"count":1,"token":"Skin"},{"count":1,"token":"Adenexal"},{"count":1,"token":"Tumor"},{"count":1,"token":"vs."},{"count":1,"token":"Hemangioma:"},{"count":1,"token":"Diagnostic"},{"count":1,"token":"Pitfall"},{"count":1,"token":"Due"},{"count":1,"token":"Cytologic"},{"count":1,"token":"Sampling"},{"count":1,"token":"Error"},{"count":1,"token":"Undifferentiated"},{"count":1,"token":"(MSCST)"},{"count":1,"token":"subtype"},{"count":1,"token":"tumors,"},{"count":1,"token":"which"},{"count":1,"token":"arise"},{"count":1,"token":"from"},{"count":1,"token":"specialized"},{"count":1,"token":"gonadal"},{"count":1,"token":"neoplasm"},{"count":1,"token":"least"},{"count":1,"token":"common"},{"count":1,"token":"form"},{"count":1,"token":"tumor."},{"count":1,"token":"There"},{"count":1,"token":"have"},{"count":1,"token":"been"},{"count":1,"token":"only"},{"count":1,"token":"cases"},{"count":1,"token":"reported"},{"count":1,"token":"literature,"},{"count":1,"token":"most"},{"count":1,"token":"histopathologic"},{"count":1,"token":"descriptions."},{"count":1,"token":"We"},{"count":1,"token":"would"},{"count":1,"token":"like"},{"count":1,"token":"report"},{"count":1,"token":"metastatic"}],"year":2008},"source":"s2","version":"v3-fos"}

dclm-424318361

Customer Reviews 4.2 out of 5 stars119 4.2 out of 5 stars Format: Blu-ray|Change Price:$13.98+ $3.49 shipping Your rating(Clear)Rate this item on October 4, 2003 I've seen all the reviews -- "overrated", "terrible". I enjoy this movie, but I do so because I watch it knowing that it is a wildly dramatic, romantic, epic tragedy. If you enjoyed Pearl Harbor, or Gone With The Wind, you'll probably enjoy Legends of the Fall. All of the actors are beautiful, the cinemetography is amazing, and with the exception of Julia Ormond (who plays Susannah as weak and insipid), the actors all turn in great, underrated performances. Brad Pitt, a fine actor who continues to be punished by critics for his sheer beauty, did a great job with a script that could have easily been over-acted - few actors could portray the depth of emotions he does and still seem masculine. Aidan Quinn was wonderful, playing the pathos of the "second fiddle" character with dignity and strength. He captured the essence of his character in a scene when he confronts his brother (Pitt) with the irony of his life: "I followed all the rules...and everyone still loved you best." Anthony Hopkins is, as always, a joy to watch, though the scenes after his stroke are a little over-done. His ability to balance the tragedy of this character's illness with his strength is a testament to his talent. So don't expect something edgy or action-based. Legends of the Fall is a great film, if you're know what your're getting when you buy (or rent) it. on November 18, 2003 When people ask me about my favorite movies I give them a quick run down of my top ten: 1. The Godfather and The Godfather part II (tie), 3. The Shawshank Redemption, 4. One Flew Over the Cukoo's Nest, 5. Schindler's List, 6. The Silence of the Lambs, 7. Amadeus, 8. The Princess Bride, 9. Legends of the Fall, 10. Goodfellas. I am always surprised when they laugh at the 9th movie on my list. I can't understand why people think this movie is a joke. Yes, it's melodramatic but it works beautifully. Let me also say that I am not the biggest fan of Brad Pitt. His acting pales in comparison to some of the other fine actors of his generation (ie. Ralph Fiennes, Gary Oldman, Sean Penn). That said, he is perfectly cast in this movie. His ruggedness and wildman image were established in 1992's A River Runs Through It and his role as Tristan in LOTF seems almost like an extension of his role in River. I've heard that Johnny Depp, an actor whose talents I find superior to Pitt's, was originally offered the role of Tristan. I'm glad he turned it down for no one other than Brad Pitt could have BEEN Tristan. I've always appreciated great acting. To me, there is nothing more entertaining than watching a De Niro, Pacino or Nicholson work his magic. There is only one truly great actor in Legends of the Fall - Sir Anthony Hopkins. In my opinion, he should have won an Oscar for this supporting role. A lot of reviewers criticized the second half of his performance (after the stroke) as being a bit excessive. I thought it was necessary in this type of film. It was because of Legends of the Fall that I took an interest in acting. Not because of Anthony Hopkins...i know I could never be half as good as he. LOTF taught me that it doesn't take great actors to make a great movie. I thought Aidan Quinn, a talented but by no means gifted actor, was brilliant in the film as the tortured victim of unrequited love. It's my opnion that Quinn delivered a top-notch performance in the film, second only to Hopkins. The scene in which Alfred (Quinn) redeems himself in his father's eyes is particularly endearing. Also, the casting of Julia Ormond as Susannah was a stroke of genius. She has such classic beauty and is wonderful at conveying emotions without speaking a word. I often wonder where the hell she disappeared to. Finally, I cannot say enough about James Horner's breathtaking score. I first became a fan of Horner's when I saw this movie and I believe him to be the top composer in the film-scoring business (yes, even better than the great John Williams). Don't listen to the critics. This movie is amazing. They just don't make 'em like this anymore. on April 20, 2003 'Legends of the Fall', is indeed a film title that brings a sense of fear and drudgery into the hearts of men across the globe who would inadvertently label this epic 'a chick flick'. Add this to the fact that the film stars none other than hollywood's finest - Brad Pitt - and one may assume that their preconception was accurate. However, what we are delivered is an epic tale that contradicts all previous misconceptions. Legends of the Fall[LOTF], depicts the tale of 3 brothers, their father, an indian tribal family and a lady, set in the late 19th early 20th century. Indeed, this does not sound very interesting , but as the story unveils through an excellent and engrossing script, LOTF shines from many other hollywood incartions as a film, where thought has been applied, rather than millions of dollars on overused special effects. The strong story is backed by some truely delightful performances form Hopkins and Pitt, and this coupled to the brilliance of Quinn and Osmond, produces a very believable tale, hypothetically of course. The cinematography employed in LOTF is nothing short of spectacular, and if watched properly on a large screen, envokes a sense of depth which is truely breathtaking at particular points. The score is strong as all epics should be and helps add depth, but may be overworked at points. However, some parts of the story are less believeable than others, and im sure this will be resonant from other critics of the film. Examples include the war scene death ritual, and the journey scenes by brad pitt, and this adds a fictional aspect to a film that, at points, exhibits characterstics of a drama. This bipolar discontinuinity is sometime frustrating and almost non-sensical, but overall does not disrpute the course of LOFT. In essence LOFT is a well crafted affair that will be rememebed either for its brilliance or for its length. It is not another mindless film where everything is corrected at the end and all characters exude with happiness, but rather an engrossing tale, which when rememebered will be thought of favourably. Overall, definetaly a film to watch, especially if you have a night free and wish to be qietly surprised on November 26, 2001 This is a beautifully made movie. The photography, particularly the composition and landscape work is enjoyable even before the actors start to speak. The costumes and sets are first class, and the actors all acquit themselves well. Director Zwick made good choices with all the lead roles, choosing star names who turn in good performances. Hopkins' performance loses subtlety towards the end, and Brad Pitt is sometimes too expressionless, but Aidan Quinn never wavers, and Henry Thomas displays the quality of innocence which led to Spielberg casting him as the star of E.T. as a boy actor. James Horner's music is emotional and appropriate, however it is sometimes too prominent in the mix. With five major stars, the film gives them equal prominence, so it would have benefited from making the characters more sympathetic. However this is a personal thing (and of course taken from the novel rather than created by the film people and you might like the realistic portrayal of rounded characters, neither wholly good, nor wholly bad. The plot is a little predictable, but this is not unusual for subject matter of this type. Just sit back and enjoy the scenery and performances. on April 13, 2003 Everyone else is reviewing the movie itself, so I'll review the Superbit DVD. In the past, whenever I had a collecter's version (with plenty of extras) versus say a DTS version (without the extras) I would choose the extras. In movies such as Apollo 13 and Saving Private Ryan I chose the collectors versions. I found over time that I stop watching the extras and just watch the movies over and over. SO, Legends of the Fall offers a great collector's version at half the price of the superbit version. So, why get the superbit? WEll, this is a BIG movie. The crispness of the picture and sound are stunning. I have over 50 DVDs and this one is right at the top with sound quality and picture quality. The separation of the surround sound in the dts is fantastic. A door opening, a dog howling in the distance, the battle sequence, the wind, and James Horner's music will be as clean and true as you can imagine. The quality of John Toll's amazing cinematography is a visual jewel. From the definition in the color of the faces to the divine imagery of the natural setting, you won't be disappointed. This film is as beautifully photographed as any I have ever seen. Now, is it worth double the cost of the loaded collector's edition? I don't know, but I bought the Superbit version and I couldn't be more pleased. The Superbit offers none of the extras that are in the collector's edition, just a breathtaking version of a gorgeous film. I kept finding myself thinking.. wow that's beautiful. This is a very emotional, moving film that the super-definition of sound and picture enhances into quite an experience. 0Comment|Was this review helpful to you?YesNoReport abuse on April 4, 2003 This movie definitely has a mythical (hence, Legends) quality to it. One of the sons, Tristan is linked to a bear in a mysterious way. The story has its share of tragedy, with a bittersweet ending. The scenery and music are beautiful and the actors portray their parts perfectly. The movie quite clearly deals with a few of the ways we can "fall" as humans and the anguish that results both for us and the ones who love us. The story shows we can fall by choosing to desire that which isn't good for us, and we can fall by believing that we are cursed by God and without hope. It shows how destructive those choices and beliefs can be. For this author, redemption is found in the bond of family. If it weren't for Isabel Two, I might say that the author was very negative toward women. The mother and Susannah are shown to be weak and Susannah is described as the unwitting demise of that all important family bond. She is like "water that flows into the crack in a rock and when it freezes, breaks the rock". I was disappointed that she seemed to not see the treasure she had in front of her and to rise up and conquer her misplaced desire. Still, the story was beautifully told and reminds us to be smarter than some of the characters! The movie paced along very well. There is quite a bit of action as well as interesting dialogue. This is not a movie that drags. There is some sex and some violence, which might be uncomfortable. However these scenes are no more shocking than a lot of movies out there. The bond of family was beautiful in this story, but they failed to bring in outsiders and make them family while maintaining that bond. This movie is well worth seeing if only for the complex interactions between the characters. Family is precious and this movie made me treasure mine even more. 0Comment|Was this review helpful to you?YesNoReport abuse on December 10, 2002 From breathtaking scenery to shots of Brad Pitt as eye-candy for the ladies, LEGENDS OF THE FALL has something for everyone. Edward Zwick brings a powerful story of brotherly love and conflict to the screen, a story that stays as fresh and vigorous as the majestic northern Rockies. The conflict that drives this story involves brothers Alfred and Tristan Ludlow (Aidan Quinn and Brad Pitt). Here are two brothers torn apart by their love for the same woman, and by Alfred's resentment that Tristan is his father's favorite son. Tristan--wild, self-destructive, guilt-ridden--must exorcise some demons of his own (and does). The film moves relentlessly toward a compelling climax, when the brothers come to one another's aid, when a father's love for his outcast son is renewed. Anthony Hopkins is brilliant as family patriarch Colonel Ludlow. LEGENDS OF THE FALL is as tough, gritty, and determined as its scenic background--as tender and poignant as any family saga ever portrayed. Highly recommended. 0Comment|Was this review helpful to you?YesNoReport abuse on November 12, 2002 If you don't like to cry at movies, don't see this one. If you don't normally cry in movies, and think that you can stay tough through anything, think again. I NEVER cry in movies, and I was nearly brought to tears about 6 times during this. Not that it was a bad movie. Not in the least. This movie really makes you care about the characters. Three brothers, a father, and the woman that drove them apart. To me, the father was the most endearing, because even when faced with the most horrific challenges, he manages to overcome them. Tristan, the main character, and his brother Alfred, both run away from their problems, only to different places, and the youngest, Samuel, didn't live long enough to have any. The catalyst is the woman, Suzanna, who first becomes engaged to Samuel, and then finds out that love isn't everything she'd wished for. (I'd tell you more, but I don't want to ruin the story.) At the edges of this brilliant picture, are the people who truly run the farm, including the old indian master, the indian/white convict couple and their half-breed daughter, who at thirteen knows that she will marry the middle son, Tristan (significantly older than her). To me, the whole movie moves forward with a self-desctrustive determinism, that no matter what happens, life continues, sometimes with even more devastating effects. The real tragedy of the movie is not what happens to Tristan, but what happens to those around him. As for visual effect, the general impression of the movie doesn't change. The boys and the father remain dressed in very similar clothes throughout the movie, having lived on a ranch almost their entire life. We see the decades change from the 1910's to the 20's to the early 30's through Suzanna's clothes, the one female in the movie with the luxury of changing fashions. The strength of this movie is in it's story, and the director has done a superb job in simply enhancing the tragedy with simple shots and simple styles, instead of loading up the visual side of it without letting the characters stand alone. To me, the whole movie's attitude is summed up by two phrases, spoken by Colonel Ludlow towards the end of the movie to his middle son, Tristan. "You're not damned, Tristan. I won't allow that." 0Comment|Was this review helpful to you?YesNoReport abuse on October 26, 2002 This review refers to the Special Edition DVD(TriStar/Columbia) Right from the start of this film, Director Edward Zwick and Cinematographer John Toll, take us on a magnificent journey through some of the most breathtaking vistas,shot mostly on the Stoney Indian Reserve near Calgary.Viewed throughout with James Horner's score is a beautiful experience right in your own living room. Three brother's, their love for each other,their father, and for one woman is the main focus of the story. Tristan is the middle son, his father's favorite, he is as wild as the Montana country where they live in the early 1900's. It is he who we follow on a journey of darkness, enlightenment and finally self-discovery.It is an epic story,that follows the lives of the Ludlow family for many years, through WWI,passion, secrets,tragedies, and bonds. The tale is narrated by Gordon Tootoosis, a Chief of the Cree nation, who was mentor to Tristan and taught him well the ways of becoming one with nature. Starring in this Cinematic treat are Brad Pitt(Tristan), Aidan Quinn,Henry Thomas, Sir Anthony Hopkins(Col. Ludlow), and as the woman they all love Julia Ormand(Suzanne).All turning in superb performances. The DVD is as much of a treat as the film itself. The film won an Academy Award for Best Cinematoghraphy in 1994 and it really shows on this edition. Colors are perfect,picture immaculate, and the sound(in 5.1 Dolby Digital)completes the total home theatre package. It is in widescreen. There's a ton of special features, including the making of featurette, some great commentary by Zwick and Pitt, and more. The movie can be played in several languages or with subtitles. If you've never seen it,this film has something for everyone, war, romance,western adventure,action,drama It will sweep you off your feet, and you will want to watch it again. If youve already seen it you will not be dissapointed with the transfer to this DVD 0Comment|Was this review helpful to you?YesNoReport abuse on October 18, 2002 Family values, brotherly love, Legend of the Fall is an epic which depicts every side of both. Watching this film, it is easy to believe that Brad Pitt, Aidan Quinn and Henry Thomas are brothers and the sons of Anthony Hopkins. The love-hate relationship between Tristan, Alfred and Samuel is almost too realistic. The iron hand of a domineering father who only knows the army way leads to desparate struggles for independence and identity. Tristin (Brad Pitt) is the middle son, favored by the father (Anthony Hopkins) because of, as well as inspite of, his wild nature. Alfred(Aidan Quinn) is the eldest son. He feels he should be most privilaged, and since he can't get honor and respect from his father, he struggles his entire life to acheive success and out do his brother. Samuel is the youngest son who is looked after by all the family. It is Samuel who brings the woman into the picture. The struggles of life and death, love and hate weave their way in and out of the story. Edward Zwick did an excellent job of blending the story with the talents of the actors. Legend of the Fall is an emotional dramatic ride. The scenery of the remote wildernes is the perfect back drop to support the legend as it unfolds. I would recommend this film to anyone who wants a good emotional drama with all the twists and turns of real life. 0Comment|Was this review helpful to you?YesNoReport abuse

dclm

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pes2o-19633333

[The role of polyol pathways in formation of diabetic cataracts]. The authors present current knowledge concerning the role of polyols in the formation of cataract in diabetic patients. Sugar alcohols are formed in lens as a consequence of glucose conversion in the sorbitol pathway. The pharmacological modulation of this process by the application of aldose reductase inhibitors are also discussed.

pes2o

{"added":"2018-04-03T05:45:05.651Z","created":"1997-01-01T00:00:00.000Z","id":"44398806","metadata":{"abstract":"The authors present current knowledge concerning the role of polyols in the formation of cataract in diabetic patients. Sugar alcohols are formed in lens as a consequence of glucose conversion in the sorbitol pathway. The pharmacological modulation of this process by the application of aldose reductase inhibitors are also discussed.","abstract_count":50,"abstract_language":"en","abstract_perplexity":-12.738173056019209,"extfieldsofstudy":["Medicine"],"provenance":"pes2o_v2-0005.json.gz:270598","s2fieldsofstudy":["Chemistry"],"sha1":"4906743bde2bcd3978d94b151c31100e48627908","sources":["Medline","MAG"],"title":"[The role of polyol pathways in formation of diabetic cataracts].","title_count":10,"title_language":"en","title_perplexity":-16.65984078812932,"top_frequencies":[{"count":7,"token":"of"},{"count":5,"token":"in"},{"count":4,"token":"the"},{"count":2,"token":"role"},{"count":2,"token":"formation"},{"count":2,"token":"diabetic"},{"count":2,"token":"The"},{"count":2,"token":"are"},{"count":1,"token":"[The"},{"count":1,"token":"polyol"},{"count":1,"token":"pathways"},{"count":1,"token":"cataracts]."},{"count":1,"token":"authors"},{"count":1,"token":"present"},{"count":1,"token":"current"},{"count":1,"token":"knowledge"},{"count":1,"token":"concerning"},{"count":1,"token":"polyols"},{"count":1,"token":"cataract"},{"count":1,"token":"patients."},{"count":1,"token":"Sugar"},{"count":1,"token":"alcohols"},{"count":1,"token":"formed"},{"count":1,"token":"lens"},{"count":1,"token":"as"},{"count":1,"token":"a"},{"count":1,"token":"consequence"},{"count":1,"token":"glucose"},{"count":1,"token":"conversion"},{"count":1,"token":"sorbitol"},{"count":1,"token":"pathway."},{"count":1,"token":"pharmacological"},{"count":1,"token":"modulation"},{"count":1,"token":"this"},{"count":1,"token":"process"},{"count":1,"token":"by"},{"count":1,"token":"application"},{"count":1,"token":"aldose"},{"count":1,"token":"reductase"},{"count":1,"token":"inhibitors"},{"count":1,"token":"also"},{"count":1,"token":"discussed."}],"year":1997},"source":"s2","version":"v3-fos"}

pes2o-16394072

Photosensitive and Biomimetic Core–Shell Nanofibrous Scaffolds as Wound Dressing Tissue engineered skin grafts that mimic the native extracellular matrix of skin has gained huge popularity among clinicians since they increase the survival rate of the patients. Phototherapy shows promising results with respect to acute and chronic pain relief, treatment of inflammatory conditions and promotion of wound healing. Here, we encapsulated a photosensitive polymer poly (3‐hexylthiophene) (P3HT) and epidermal growth factor in the core–shell‐structured Gelatin/poly(L‐lactic acid)‐co‐poly‐(ε‐caprolactone) nanofibers [Gel/PLLCL/P3GF(cs)] by coaxial spinning and studied the potential application of the Gel/PLLCL/P3GF(cs) nanofibrous scaffold as a novel skin graft. The proliferation of fibroblasts was significantly improved on Gel/PLLCL/P3GF(cs) under light stimulation compared to fibroblasts on the same scaffold under dark condition. Studies on the in vitro wound healing ability of Gel/PLLCL/P3GF(cs) showed complete closure of wound after 9 days under “light stimulation” too. Furthermore, the potential of adipose‐derived stem cells (ASCs) to differentiate to epidermal cells on Gel/PLLCL/P3GF(cs) was evaluated. The differentiated ASCs with keratinocytes morphology were only found on the light stimulated Gel/PLLCL/P3GF(cs). Our results suggest that the photosensitive core–shell Gel/PLLCL/P3GF(cs) nanofibers could be a novel substrate to aid in the reestablishment of skin architecture.

pes2o

{"added":"2018-04-03T01:22:50.170Z","created":"2014-05-01T00:00:00.000Z","id":"29239145","metadata":{"abstract":"Tissue engineered skin grafts that mimic the native extracellular matrix of skin has gained huge popularity among clinicians since they increase the survival rate of the patients. Phototherapy shows promising results with respect to acute and chronic pain relief, treatment of inflammatory conditions and promotion of wound healing. Here, we encapsulated a photosensitive polymer poly (3\u2010hexylthiophene) (P3HT) and epidermal growth factor in the core\u2013shell\u2010structured Gelatin\/poly(L\u2010lactic acid)\u2010co\u2010poly\u2010(\u03b5\u2010caprolactone) nanofibers [Gel\/PLLCL\/P3GF(cs)] by coaxial spinning and studied the potential application of the Gel\/PLLCL\/P3GF(cs) nanofibrous scaffold as a novel skin graft. The proliferation of fibroblasts was significantly improved on Gel\/PLLCL\/P3GF(cs) under light stimulation compared to fibroblasts on the same scaffold under dark condition. Studies on the in vitro wound healing ability of Gel\/PLLCL\/P3GF(cs) showed complete closure of wound after 9 days under \u201clight stimulation\u201d too. Furthermore, the potential of adipose\u2010derived stem cells (ASCs) to differentiate to epidermal cells on Gel\/PLLCL\/P3GF(cs) was evaluated. The differentiated ASCs with keratinocytes morphology were only found on the light stimulated Gel\/PLLCL\/P3GF(cs). Our results suggest that the photosensitive core\u2013shell Gel\/PLLCL\/P3GF(cs) nanofibers could be a novel substrate to aid in the reestablishment of skin architecture.","abstract_count":183,"abstract_language":"en","abstract_perplexity":-17.894598606888774,"extfieldsofstudy":["Chemistry","Medicine"],"provenance":"pes2o_v2-0004.json.gz:907465","s2fieldsofstudy":["Biology","Medicine"],"sha1":"bbfb6757db16c25add788b1b64058dc27fb4fa93","sources":["Medline","Wiley","Unpaywall","MAG","MergedPDFExtraction"],"title":"Photosensitive and Biomimetic Core\u2013Shell Nanofibrous Scaffolds as Wound Dressing","title_count":9,"title_language":"en","title_perplexity":-18.294705696393702,"top_frequencies":[{"count":12,"token":"the"},{"count":10,"token":"of"},{"count":5,"token":"and"},{"count":5,"token":"to"},{"count":5,"token":"Gel\/PLLCL\/P3GF(cs)"},{"count":5,"token":"on"},{"count":4,"token":"skin"},{"count":3,"token":"wound"},{"count":3,"token":"a"},{"count":3,"token":"in"},{"count":3,"token":"under"},{"count":2,"token":"as"},{"count":2,"token":"that"},{"count":2,"token":"results"},{"count":2,"token":"with"},{"count":2,"token":"photosensitive"},{"count":2,"token":"epidermal"},{"count":2,"token":"nanofibers"},{"count":2,"token":"potential"},{"count":2,"token":"scaffold"},{"count":2,"token":"novel"},{"count":2,"token":"The"},{"count":2,"token":"fibroblasts"},{"count":2,"token":"was"},{"count":2,"token":"light"},{"count":2,"token":"cells"},{"count":1,"token":"Photosensitive"},{"count":1,"token":"Biomimetic"},{"count":1,"token":"Core\u2013Shell"},{"count":1,"token":"Nanofibrous"},{"count":1,"token":"Scaffolds"},{"count":1,"token":"Wound"},{"count":1,"token":"Dressing"},{"count":1,"token":"Tissue"},{"count":1,"token":"engineered"},{"count":1,"token":"grafts"},{"count":1,"token":"mimic"},{"count":1,"token":"native"},{"count":1,"token":"extracellular"},{"count":1,"token":"matrix"},{"count":1,"token":"has"},{"count":1,"token":"gained"},{"count":1,"token":"huge"},{"count":1,"token":"popularity"},{"count":1,"token":"among"},{"count":1,"token":"clinicians"},{"count":1,"token":"since"},{"count":1,"token":"they"},{"count":1,"token":"increase"},{"count":1,"token":"survival"},{"count":1,"token":"rate"},{"count":1,"token":"patients."},{"count":1,"token":"Phototherapy"},{"count":1,"token":"shows"},{"count":1,"token":"promising"},{"count":1,"token":"respect"},{"count":1,"token":"acute"},{"count":1,"token":"chronic"},{"count":1,"token":"pain"},{"count":1,"token":"relief,"},{"count":1,"token":"treatment"},{"count":1,"token":"inflammatory"},{"count":1,"token":"conditions"},{"count":1,"token":"promotion"},{"count":1,"token":"healing."},{"count":1,"token":"Here,"},{"count":1,"token":"we"},{"count":1,"token":"encapsulated"},{"count":1,"token":"polymer"},{"count":1,"token":"poly"},{"count":1,"token":"(3\u2010hexylthiophene)"},{"count":1,"token":"(P3HT)"},{"count":1,"token":"growth"},{"count":1,"token":"factor"},{"count":1,"token":"core\u2013shell\u2010structured"},{"count":1,"token":"Gelatin\/poly(L\u2010lactic"},{"count":1,"token":"acid)\u2010co\u2010poly\u2010(\u03b5\u2010caprolactone)"},{"count":1,"token":"[Gel\/PLLCL\/P3GF(cs)]"},{"count":1,"token":"by"},{"count":1,"token":"coaxial"},{"count":1,"token":"spinning"},{"count":1,"token":"studied"},{"count":1,"token":"application"},{"count":1,"token":"nanofibrous"},{"count":1,"token":"graft."},{"count":1,"token":"proliferation"},{"count":1,"token":"significantly"},{"count":1,"token":"improved"},{"count":1,"token":"stimulation"},{"count":1,"token":"compared"},{"count":1,"token":"same"},{"count":1,"token":"dark"},{"count":1,"token":"condition."},{"count":1,"token":"Studies"},{"count":1,"token":"vitro"},{"count":1,"token":"healing"},{"count":1,"token":"ability"},{"count":1,"token":"showed"},{"count":1,"token":"complete"},{"count":1,"token":"closure"}],"year":2014},"source":"s2","version":"v3-fos"}

pes2o-2661605

Some States Take the Lead: Explaining the Formation of State Technology Policies The focus on economic development has largely been a substantive one. Researchers have sought to determine what policies states are employing, which are most effective, and which policies work best in which types of regional economies. However, procedural questions regarding how state political and institutional arrangements affect the funding and design of these policies have been virtually ignored. This article presents results of a research project that examined the policy-making processes engaged by six states to determine the factors that contributed to the development of more or less effective state technology policy efforts. A number of policy-making factors were found to have a significant influence on the effectiveness of state technology efforts. States which relied on an "active stewardship" mode of policy making were able to develop more effective policy efforts than states which relied on the "business as usual" mode.

pes2o

{"added":"2019-05-15T14:32:36.832Z","created":"1991-02-01T00:00:00.000Z","id":"153887830","metadata":{"abstract":"The focus on economic development has largely been a substantive one. Researchers have sought to determine what policies states are employing, which are most effective, and which policies work best in which types of regional economies. However, procedural questions regarding how state political and institutional arrangements affect the funding and design of these policies have been virtually ignored. This article presents results of a research project that examined the policy-making processes engaged by six states to determine the factors that contributed to the development of more or less effective state technology policy efforts. A number of policy-making factors were found to have a significant influence on the effectiveness of state technology efforts. States which relied on an \"active stewardship\" mode of policy making were able to develop more effective policy efforts than states which relied on the \"business as usual\" mode.","abstract_count":141,"abstract_language":"en","abstract_perplexity":-12.455533727758114,"extfieldsofstudy":["Economics"],"provenance":"pes2o_v2-0000.json.gz:2661606","s2fieldsofstudy":["Economics"],"sha1":"1a21dd7df3627bb6120dbe560ba0fc3de021f67c","sources":["Sage","MergedPDFExtraction","Unpaywall","MAG"],"title":"Some States Take the Lead: Explaining the Formation of State Technology Policies","title_count":12,"title_language":"en","title_perplexity":-12.009027939909876,"top_frequencies":[{"count":8,"token":"the"},{"count":8,"token":"of"},{"count":5,"token":"to"},{"count":5,"token":"which"},{"count":4,"token":"on"},{"count":3,"token":"a"},{"count":3,"token":"have"},{"count":3,"token":"policies"},{"count":3,"token":"states"},{"count":3,"token":"and"},{"count":3,"token":"state"},{"count":3,"token":"policy"},{"count":2,"token":"States"},{"count":2,"token":"development"},{"count":2,"token":"been"},{"count":2,"token":"determine"},{"count":2,"token":"are"},{"count":2,"token":"that"},{"count":2,"token":"policy-making"},{"count":2,"token":"factors"},{"count":2,"token":"more"},{"count":2,"token":"effective"},{"count":2,"token":"technology"},{"count":2,"token":"efforts."},{"count":2,"token":"were"},{"count":2,"token":"relied"},{"count":1,"token":"Some"},{"count":1,"token":"Take"},{"count":1,"token":"Lead:"},{"count":1,"token":"Explaining"},{"count":1,"token":"Formation"},{"count":1,"token":"State"},{"count":1,"token":"Technology"},{"count":1,"token":"Policies"},{"count":1,"token":"The"},{"count":1,"token":"focus"},{"count":1,"token":"economic"},{"count":1,"token":"has"},{"count":1,"token":"largely"},{"count":1,"token":"substantive"},{"count":1,"token":"one."},{"count":1,"token":"Researchers"},{"count":1,"token":"sought"},{"count":1,"token":"what"},{"count":1,"token":"employing,"},{"count":1,"token":"most"},{"count":1,"token":"effective,"},{"count":1,"token":"work"},{"count":1,"token":"best"},{"count":1,"token":"in"},{"count":1,"token":"types"},{"count":1,"token":"regional"},{"count":1,"token":"economies."},{"count":1,"token":"However,"},{"count":1,"token":"procedural"},{"count":1,"token":"questions"},{"count":1,"token":"regarding"},{"count":1,"token":"how"},{"count":1,"token":"political"},{"count":1,"token":"institutional"},{"count":1,"token":"arrangements"},{"count":1,"token":"affect"},{"count":1,"token":"funding"},{"count":1,"token":"design"},{"count":1,"token":"these"},{"count":1,"token":"virtually"},{"count":1,"token":"ignored."},{"count":1,"token":"This"},{"count":1,"token":"article"},{"count":1,"token":"presents"},{"count":1,"token":"results"},{"count":1,"token":"research"},{"count":1,"token":"project"},{"count":1,"token":"examined"},{"count":1,"token":"processes"},{"count":1,"token":"engaged"},{"count":1,"token":"by"},{"count":1,"token":"six"},{"count":1,"token":"contributed"},{"count":1,"token":"or"},{"count":1,"token":"less"},{"count":1,"token":"A"},{"count":1,"token":"number"},{"count":1,"token":"found"},{"count":1,"token":"significant"},{"count":1,"token":"influence"},{"count":1,"token":"effectiveness"},{"count":1,"token":"an"},{"count":1,"token":"\"active"},{"count":1,"token":"stewardship\""},{"count":1,"token":"mode"},{"count":1,"token":"making"},{"count":1,"token":"able"},{"count":1,"token":"develop"},{"count":1,"token":"efforts"},{"count":1,"token":"than"},{"count":1,"token":"\"business"},{"count":1,"token":"as"},{"count":1,"token":"usual\""},{"count":1,"token":"mode."}],"year":1991},"source":"s2","version":"v3-fos"}

flan-16812529

input question: OPTIONS: - negative - positive. Generate a tweet that has the following sentiment: positive Generated tweet: O_o... im bored... but my room is looking nice and clean input question: OPTIONS: - negative - positive. Generate a tweet that has the following sentiment: negative Generated tweet: @aflevitt my pops is a park ranger for California state parks. not sure what's gonna happen. He might end up in Colorado. Boo!!! input question: OPTIONS: - negative - positive. Generate a tweet that has the following sentiment: positive Generated tweet: @trendebarbie7 LOL!!!!! I luv u more!!!!!! ok, so guess what I'm going 2 start calling u, E, D, Brit and everybody else??? input question: OPTIONS: - negative - positive. Generate a tweet that has the following sentiment: positive Generated tweet: @LexiouWest LOL Awwww cuute I'll wait to see.

flan

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wikipedia-4937019

Chesil Beach cannon The Chesil Beach cannon consists of the remains of an unknown wreck were found on Chesil Beach, Dorset, England in 2010. The site was designated on 18 July 2017. The wreck is a Protected Wreck managed by Historic England. The wrecks. The site consists of two areas with clusters of cannon. The inshore site () consists of eight English 24– to 32-pounder cast-iron cannon dated to between 1650 and 1725 which are believed to represent the wreck of a merchant ship carrying the cannon as cargo. South of this site, a secondary offshore site () consists of seven cast iron English cannon, one of which is dated to the second half of the seventeenth century. The offshore site has been interpreted as the wreck of a different vessel, potentially carrying the guns as armament rather than cargo, evidenced by iron shot present in the mouth of the bore of one cannon which indicates it was loaded. Discovery and investigation. The site was discovered in 2010 by the Shipwrecks Project. The sites were investigated by Wessex Archaeology in 2015; this involved a programme of diving surveys. A number of archaeological finds of similar dates have been identified near the sites since the 1970s including a large plug of tobacco found below a cannon up to 500m to the northwest of the sites. Shot, a brass barrel spigot, and some silver Dutch coins have also been found in the vicinity of the sites. Identity. Neither of the sites have been attributed to a specific wreck, however, there are some contenders for possible identities. The Dutch West Indiaman "De Hoop" became stranded at Chesil Cove in 1749 while travelling from Jamaica to Amsterdam carrying gold and silver coins, textiles, and tobacco. She was described as armed. Another possible identity is "Squirrel" which was a cargo vessel stranded on Chesil Beach in 1750 carrying tobacco. These ships may be represented by the Chesil Beach sites; however, they date to considerably later than the believed date of the cannon at the sites, and there is currently no archaeological evidence to confirm the identities of either of the wrecks.

wikipedia

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dclm-414285627

Twitter Facebook Instagram Subscribe Pinterest Flickr My other social media. Search Blatherings I'm Bored Bonus Page I'm Worried « school crushes | Main | guest blather: andrea » private dancing So 'fess many of you ever dance by yourselves, alone in the living room? I confess I have done this, usually when doing housework (hey, it's a way of perking up the vacuuming experience, right?). My favourite albums for this sort of thing: any Erasure album, Barenaked Ladies' STUNT, Indigo Girls. I remember HATING dances in high school. Never went to any (ok, I went to just one, but that was enough), even avoided going to my high school prom. I mainly disliked it because I hated the social pressure ("C' and have some FUN": implying, of course, that you weren't having fun if you weren't out on the dance floor) and also because I dreaded being the only girl left on the sidelines not being asked for a dance. (and of course it never crossed my mind that -I- could actually be the one doing the asking) Years later, though, I found that dancing could actually be fun if you were with the right crowd. Or by yourself. :-) Jeff's pretty patient with my private dancing habits. He'll be putting his laundry away, for example, while I have one of my favourite CDs cranked up and am bopping around all over the room, knocking over his neatly stacked piles of clothes, etc. Hey, and sometimes he'll even stop folding his underwear to dance with me. :-) Which brings up a whole 'nuther topic, of many of you FOLD your underwear before putting it away (and if so, how many TIMES?) as opposed to 'toss your underwear in a drawer' types like me? I'm becoming convinced it's a male/female thing, but I'm willing to be proven wrong. On a related topic, I'd like to try contradancing sometime. My friend Andrew (who helped me write TECHNONERDBOY) is visiting from California (he works for Apple Computers...brought me APPLE EARRINGS, woohoo!). I told him he had to write a blather: Guest Blatherer: Andrew Platzer Technonerdboy - never heard of it. (Debbie has said she wouldn't censor me so...) The next time you see Debbie, try something that she always appreciates. ;-) Sneak up behind her and poke her on each side at waist level. She always jumps and makes a delightful *squeak* noise when you do it. As for the underwear thing, I either fold or just toss depending on how tired I feel. There goes Debbie's theory out the window. Officemusic: Barenaked Ladies' STUNT. Reader Comments Editor Permission Required

dclm

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