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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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testing the paradigm of a single plastid origin in eukaryotes
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photosynthesis was acquired by eukaryotes through endosymbiosis with cyanobacteria which resulted in new cellular organelles the plastids from the origin of plastids evolved the first eukaryotic algae giving rise to land plants but also triggering the evolution of most photosynthetic eukaryotes by subsequent endosymbioses between these first algae and other eukaryotes thus the origin of plastids profoundly changed the course of eukaryotic life by being the launching point that shaped the biological diversity of most primary producers despite this importance our understanding of how plastids originated remains largely uncertain the current paradigm describes this transformative event as a single primary endosymbiosis but i argue here that critical data is lacking notably from the vast hidden environmental diversity of microbes to adequately test this hypothesis in this project i propose to gain insight into the origin of plastids by addressing the main questions 1 what is the currently hidden diversity of highranked taxa related to primary photosynthetic lineages 2 what are the feeding behaviors of these taxa and are they aplastidic 3 are some lineages genetically predisposed to establish plastids from the acquisition of foreign genes 4 what was the composition size and origin of the ancestral primary plastid proteomes to answer these questions i will link third generation environmental sequencing transcriptomics and genomics to cell structure and behavior of novel key lineages related to primary algae and produce crucially missing plastid proteomes to allow comprehensive comparative proteomic analysis my project will not only have immediate implications on our understanding of the origin of plastids and more generally the fundamental process of endosymbiosis but the approaches developed will be a test bed for future global studies aimed at understanding the evolution and ecology of the microbial majority of complex life
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stable isotope study of bone and dental remains hydrogen and oxygen methodological developments
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the study of the interactions between ancient societies and their environment is a key element to decisionmaking in the global context of climate change stable isotope analysis of biological bone and dental remains provides insights into climatic conditions dietary habits and geographical mobility of modern and past populations the ishod project sets up to refine the analysis and interpretation of two proxies the hydrogen d2h and oxygen d18o stable isotope compositions of animal and human remains from modern and archaeological contextstraditionally d2h and d18o values are respectively measured on distinct matrices bioapatite for d18o and collagen for d2h both proxies face analytical atom exchange during pretreatment procedures and interpretative what information are recorded challenges ishod aims to develop 1 d2h measurements of bioapatite and whole bone and 2 d18o measurements of collagen once operational protocols and setups will be used to explore how d2h and d18o values compare with other isotopic systems c n s sr and record climate diet and geographic origin they will be applied to investigate the medieval city of ieper western flanders belgiumi will be hosted at vrije universiteit brussels and supervised by prof christophe snoeck a renowned expert in bioarchaeology specialized in isotope analysis of animal and human remains during the fellowship i will be trained to improve my scientific stable isotope facility operating pretreatment expertise and interpersonal leadership networking skills ishod will lead to new chemical procedures and analytical setups to perform d2h and d18o measurements which will advance our understanding of how ancient european societies experienced and adapted to climate changes the projects outcomes will be presented at scientific conferences eaa ukas goldschmidt and publicly communicated during outreach events urban archaeology day dag van de wetenschap
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ocean night helping society understand the importance of the marine ecosystem
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life started in the oceans oceans cover the majority of earths surface and are the single largest ecosystem on the planet billions of humans live in coastal areas and depend on the functioning of this ecosystem to live unfortunately human activities are seriously endangering the health of the marine ecosystem it is therefore critical to raise awareness of the richness of this ecosystem its importance the challenges it faces and what we as citizens of the world can do to improve and preserve it through our personal choices with the mcsa researchers night proposal ocean night we aim to contribute to this challenge by raising marine science literacy across the general population and promoting the appreciation of the importance of the marine ecosystem our proposal brings together all public research institutes across spain working on marine science for a comprehensive 2years outreach program we will leverage the substantial outreach experience of the institutes to deliver a diverse and coherent program of events aimed at engaging a geographically wide and socially diverse set of regions within spain
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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space4earth
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globeeye provides a new unique and complete perspective on global economic environmental and social developmentsleveraging frontier technologies in space data and artificial intelligence it delivers valuable insights for decisionmakers in financebusiness and government it contributes to overcoming out times major challenges and arguably humanitys greatest threats ofclimate change biodiversity loss and natural capital depletionin particular globeeye is focused on developing next generation sustainability esg metrics thanks to stateofthe art deep learningmodels it combines satellite data with a vast range of remote sensing groundbased alternative and observational data to generateunprecedented information sets and predictions the result is independent verifiable and actionable sustainability esg indicatorsesg indicators have vast possible applications both in the private and in the public sector but are most crucial for green finance byproviding reliable data globeeye enables and supports the transition towards green finance and sustainable investment decisionsrisk management and related regulatory effortsour space4earth proposal highlights how the women tech eu programme can globeeye step up to the next stage of growth andhow it comes at the perfect time for our development stage the programme provides the needed funding coaching and contacts totake the business planning and management steps to prepare the startup for the next phase of funding and growth
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the best way to know your health we have integrated a medical device into a toilet allowing people to take an autonomous exam related to several health parameters with simplicity and regularity
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abluteis the best way to know your health by integrating a urinalysis device into a waterefficient toilet people can take exams with the simplicity of using a bathroom regular screening is the most reliable method to early detect diseases ablute delivers simplicity to health examination fostering regularity the equipment analysis several biomarkers simultaneously and delivers immediate results via software if a sign of a condition is detected an alert is emitted catching the physician and patients attention to that condition at its early stagesthe data transmitted is used for accessing patients health but also for rd purposes on one hand the biomarkers related to the analysis of diabetes chronic kidney disease inflammation and hypertension are already standardized thus the medical community already accepts them as the common used mean to monitor and detect those conditions on the other hand the biomarkers endorsed by ablute for the analysis of 5 types of cancer breast prostate colorectal bladder and ovarian even though already validated by the scientific community with high levels of sensitivity and specificity are still in progress for being perceived as valid by the medical community ablute combine the analyses of these innovative oncological biomarkers with the standard ones delivering relevant information while working on further validation the toilet can be used for common purposes however in order to perform urinalyses the user needs to enable a connection by pairing it with an nfc device or through facial recognition once connected the toilet will open itself automatically and the person can use it like a regular toilet ablute completely automatizes the process of taking a health screen it collects a urine sample analyzes it and delivers the results ablutes goal is to democratise health examination step by step we are providing people with the necessary means to be the healthiest version of themselves
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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ancient viruslike transposons from horizontal gene transfer to the evolution of novelty
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from antiparasitic toxins in butterflies to antifreeze proteins in fish horizontal gene transfer hgtthe nonsexual exchange of genes between specieshas been observed in all major eukaryotic lineages however one of its most fascinating aspects the transfer mechanism remains a mystery despite decades of research how can dna leave the donor species come in close contact with the germline of a second species and integrate in the genome of its new host our lab made a significant breakthrough in our understanding of this process that now allow us to address these questions experimentally we discovered that mavericks ancient eukaryotic transposable elements related to giant viruses and adenoviruses have mediated the widespread transfer of genes between highly divergent nematode species on a global scale the gene content of mavericks suggests that they have a dual lifestyle both as transposons and as infective enveloped viruses yet how they accomplish hgt at the molecular level is unknown having pioneered the identification of the first hgt vector in animals the objectives of the topgun proposal are to dissect the molecular basis of hgt elucidate its impact on evolution and reveal general principles of hgt across eukaryotes to achieve this i propose the following aims1 to uncover the life cycle of mavericks and reconstitute horizontal gene transfer in the lab2 to dissect the impact of mavericks and their cargos on molecular innovation and genome evolution3 to systemically discover vectors of horizontal gene transfer across eukaryotes in silicomy team and i will pursue these objectives by applying a multidisciplinary approach combining genetics functional genomics biochemistry and structural biology we believe that topgun will ignite hgt as a new experimental research field and catalyse the development of new payload delivery systems for parasitic nematodes most of which cannot be genetically modified due to their complex life cycle
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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synthetic antibody synab receptors for the detection and isolation of cyclic depsipeptide cdp toxins in food samples
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food safety plays a critical role in society when it comes to avoiding food poisoning most of the attention goes to preventing microbial growth in food products however the cause of intoxication is the presence of toxins produced by these microorganisms yet standard industrial or household food processing and preparation techniques effective at removing the producing microorganisms fail to remove the actual toxins as a result these toxins which typically are not detected in routine microbial food analysis are consumed daily by the general population beauvericin bea and enniatin b enn b are mycotoxins produced on crops that can easily end up in the final food or feed products other examples include cereulide cer which is produced by bacteria and has a high prevalence in readytoeat foods multiple consequences and even fatalities have been reported due to the consumption of food contaminated with beaenn or cer and as such the detection and sequestration of these toxins is of utmost importance both in public health and economic terms as well as from a broader stakeholder perspectivedespite numerous attempts worldwide the current state of the art does not allow the production of antibodies against cer bea or enn b via classical animal immunization this hampers the creation of a fast robust inexpensive and onfield kitbased detection system for these toxins in food commodities in the current project i intend to use artificial synthetic antibodies synabs that bind to these toxins ionophoric cyclic depsipeptides to produce valuable technologies for detecting and isolating these toxins in complex food samples
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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a step change in prediction mapping acceptance testing and costeffective mitigation for railway noise and vibration
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quieterrail aims to introduce a step change in predicting and mapping railway noise and vibration in the acceptance testing of rolling stock and in promoting costeffective noise mitigation the established twinsbased approach for rolling noise is extended to include curves squeal noise models are developed including flanging noise and multiple wheelrail contact points proposals are made for improving the cnossos curve noise factor based on project results to add flexibility to acceptance testing transposition methods are developed and tested for situations where there are larger differences eg between slab and ballast track measurement uncertainty in passby noise is studied including the effects of site geometry a virtual test method for the noise from freight wagons is proposed and information is gathered on the noise from trains with new propulsion technologyquieterrail produces guidelines and a data analysis tool for costeffective noise mitigation by controlling rail roughness using onboard measurement systems it also provides an opensource tool for whole track system optimisation addressing life cycle costs noise and vibration simultaneously the goal is to enhance the costeffectiveness and social benefits of railway infrastructure by reducing externalitiesa fastrunning hybrid vibration prediction method will be enhanced to include features pertinent to urban situations it will be implemented in a gisbased environment to allow mapping of vibration alongside noise the database with soil impedance and transfer functions and building correction factors will be substantially extended a trackindependent vehicle indicator is developed to allow a first step towards quantifying the vibration emission of trains and the introduction of vibration limit valuesextensive noise and vibration measurements at a mainline site and on an urban light rail network provide for validation of the results and expansion of relevant databases
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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improving green innovation for the blue revolution new tools and opportunities for a more sustainable animal farming
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animal health and welfare are issues of high research priority for european aquaculture in particular improving animal welfare whilst reducing the use of veterinary drugs are current research priorities in line with minimizing the environmental impact of the industry preventing or reducing the impact of disease is of prime importance for producers researchers and stakeholders in addition public awareness of aquatic animal health and welfare leads to the increased attention of policymakers scientific community and the consumers into new methods for disease preventionthe ignition project aims to unveil new knowledge regarding animal welfare in the context of climate change and propose new tools to mitigate the adverse effects of stress an improvement in animal welfare will translate in higherquality farmed animals thus improving farming productivity and sustainability performance through ignition it is expected to provide new knowledge through genotyping and molecular phenotyping techniques to develop future breeding strategies for fish and shellfish new innovative tools regarding immunization in fish will also be provided aiming at improving fish welfare and targeting early life stages animal feeds will be formulated to include bioactive compounds extracted from halophytes through a novel upstream cascade salt removal special emphasis will be given to the study and discovery of new noninvasive biomarkers of health and welfare which will in turn allow the development of biosensors and disease prediction through machine learning approaches the tools developed in ignition will be able to avoid the colonization and spread of pathogenic microorganisms including multiresistant microorganisms among farmed animals and the subsequent spread to humans through the food chain
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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when was greenland green perspectives from basal ice and sediments from ice cores
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green2ice will investigate the deepest and oldest ice and basal sediments drilled from the greenland ice sheet gris ice cores have been drilled the last 55 years but the deepest ice containing basal materials has been preserved until now and still holds undeciphered paleoclimatic messages the breakthrough of green2ice is to develop and apply cutting edge dating methods on this unique sample collection and hence to reconstruct the age and the stability of the gris a hypothesis to test is if the present gris formed at the time of the mid pleistocene transition 12 08 million years ago one innovation of green2ice is to gain paleoinformation of the past size of the gris to constrain future tipping points this knowledge will reduce the uncertainty on estimates of future sea level rise green2ice will bring together four pis from three world leading institutions with complementary skills to lift this strongly interdisciplinary program we will drill a replicate core at grip to supplement the available material from five existing ice cores and ensure retrieval of sediments and rock material from beneath the gris summit we will develop improve and apply novel dating techniques cosmogenic and radiogenic nuclides oslirsl modeling of gas and isotope diffusion to place constraints on past waxing and waning of the gris stateoftheart methodologies on fossil remains organic matter in situ produced and consumed greenhouse gases and ancient biomolecules will provide insights on the types of ecosystems and environmental conditions that emerged during icefree conditions interpretation will include ice sheet modelling with data benchmarking to establish the climatic sensitivity of the gris earth system modelling and collaboration with the groups preparing the ipcc ar7 will bring the knowledge of the past into the future the rare and unique basal ice and material can only be used once this is the main high risk high gain component of green2ice
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zeroco2 cement through carbonation of calcium silicates and aluminates
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contrabass zeroco2 cement through carbonation of calcium silicates and aluminateswe live in a world of concrete according to the global cement and concrete association gcca cement is consumed at a rate of 150 tonnes each second and it accounts for approximately 8 of all co2 emissions and 7 of industry energy use in order to mitigate the negative environmental impacts of concrete carbon capture and utilization ccu is the best available strategy the gcca estimates that ccu technologies will represent up to 42 of the co2 reductions necessary to reach the net zero industrial objective in 2050 the contrabass mscadn will act in this framework in the pathway towards the zeroco2 cement and concrete production building a highquality doctorate network dn to investigate the fundamental physicochemical processes governing the carbonation of the clinker phases and the cement paste as well as the subsequent formation of calcium carbonate cements cccs the carbonation ability of clinker and cement is well known yet for a full implementation of cccs by 2050 there is an urgent need of fundamental knowledge on the carbonation process in this scenario the contrabass dn aims to contribute to the global reduction of co2 emissions by accelerating the implementation of calcium carbonate cements developing fundamental knowledge practical knowhow and a generation of welltrained specialists to overcome the main challenges identified by our industrial and academic partners contrabass has 5 main objectives1 to identify the carbonation mechanisms of the clinker components specially calcium aluminates 2 to understand the carbonation processes of the csh gel and the cement paste3 to unravel the factors that govern caco3 polymorphism nucleation and growth rates4 to build databases for thermodynamic and reactivetransport modelling of carbonation5 to communicate effectively the benefits of cccs to society media and policy makers
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computational scanning for responding clonotypes in immune repertoires
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personalized medicine promises to exploit the diversity of human immune repertoires to design targeted t cell and b cellbased vaccines and therapeutics however even for mass vaccine design identifying responding clonotypes to new viruses is costly labor intensive and time consumingrespond turns existing algorithmic solutions for identifying responding immune clonotypes into a userfriendly platform to aid drug and therapeutics discovery respond combines different algorithmic solutions and finds the best computational approach to fit the users needs it is based on four methods developed during the erc cog struggle project alice noiset fstar and hlaguessr they are based on different properties of responding clonotypes from sequence similarity to abundance and publicness the idea of respond is to integrate these features in a userfriendly tool that exploits the strengths of all methods to find the best answer to the practitioners query respond will return lists of candidates for responding clonotypes and a statistical analysis of their occurrence in databssescollaborating with big pharma startups medical researchers and practitioners respond will develop computational solutions to reduce the costs of biotechnological discovery and significantly decrease the time to test new vaccines and treatments based on consulting and feedback we will aim to give the user what they need in an appealing interface the tool will be of use for everyone involved in exploiting immune repertoires for treatment and prophylactics from personalized medicine mass vaccine design to agriculture respond will pursue commercialization and market solutions both within academia the biotechnology and medical sectors
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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protein landscapes the political geography of the production and consumption of animal proteins
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despite the devastating effects of the meatdairy industry on climate and environment the production and consumption of animalbased protein is at historically high levels i refer to this as the protein paradox why are we collectively unable to reduce our reliance on meat and dairy from the extant literature we know that changing diet is difficult especially as the consumption of meat and dairy is culturally normalized in many societies the literature also reveals that the meatdairy industry has an outsize influence over consumers and governments these explanations however ignore the uneven geographies of production and consumption and how they intersect with the political contestation of meat and dairy entwining with processes of spatial and political polarizationproteinscapes thus asks how can the protein paradox be explained through the political geographies of the production and consumption of animal protein the research team will pursue 1 a quantitative study of the protein paradox and landscapes of production and consumption across all eu countries 2 indepth qualitative casestudy of the politics of consumption in the czech republic denmark the netherlands and portugal and 3 a crossnational comparative study of the role of geography in the political contestation of the transition away from animal proteinby extending and connecting theory on the geography of transitions and politicalspatial polarization to advance a new political geographical approach to study transitions to sustainability and by advancing the concept of protein landscapesproduced at the intersection of territories identities and materialitiesthe project will further our understanding of why the transition away from animal protein is so difficult the necessary first step in disentangling the wicked problem of the protein paradox
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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the chromite record of mafic crustal growth
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understanding earths crustal growth is crucial to understanding the evolution of its tectonics the birth of the first continents and the fundamental changes that transformed earth into a habitable planet however much of our understanding of earths crustal growth is predicated on a single mineral zircon that is strongly biased towards detecting felsic crustal growth this is particularly problematic for the early earth where average crustal compositions were far more mafic than today and the very first protocrust may be entirely undetectable using conventional methods i propose to access the mafic to ultramafic crustal growth record using detrital chromite preserved in sedimentary rocks from archaean cratons like zircon chromite chemical compositions reflect the magmas that they crystallised from and can be used to identify the provenance of the mafic portions of a sedimentary rock furthermore they can be dated using reos isotopes to identify the age of eroded mafic terranes this project has three main objectives1 develop techniques to identify the age and composition of chromite sources in ancient sedimentary rocks2 use a range of detrital chromite samples from sedimentary sequences in the superior craton to reconstruct a maficultramafic crustal growth curve for the craton3 search for evidence of earths mafic protocrust in some of the oldest known chromitebearing sedimentary rocksthese achievements will open a new avenue for studying sedimentary provenance unlock the archive of mafic crustal growth throughout earth history and provide insights on the nature and survival of earths earliest crust the techniques developed will be broadly applicable paving the way for a better understanding of earths crustal evolution
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identifications a psychoanalyticpolitical study of performances countering intraeuropean cultural racism
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the enlargement of the european union to include central and eastern europe 2004 2007 brought with it the rise of rightwing politics in western europe factors that contributed to the ensuing institutionalisation of rightwing parties include the european debt crisis 20092018 the imposing of austerity measures and the unprecedented influx of migrants from the middle east and africa during a period that has been termed the european migrant crisis 20152019 as living standards fell farright politicians blamed the decline on both internal and external immigrants and refugees by singling out incomers as a threat to economic and cultural stability the rightwing populists began galvanising processes of identification among citizens through the use of discourses of intolerance a newlyfortified cultural racism provided followers with a mechanism of legitimacy for their rightwing beliefs this research project will study the intricate interplay of performance and race it will investigate the ways in which both leftleaning civic performances civil protests speeches policies and artistic performances theatre dance music are capable of mobilising processes of identification that draw upon antiracist discourses that permeate and sustain democratic institutions turning to discourse theory and using a selfcritical western european lens the project will explore processes of identification that contest cultural racism
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strengthening the resilience of textile aerospace and construction smes to transition towards greener and more digital sectors with social and business innovation
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in transit aims to strengthen the resilience of textile aerospace and construction smes towards greener and more digital sectors withsocial and business model with a mixed support mechanism including individual assessment support and a lump sum and coachingto ensure their consolidation and sustainabilityin transit will provide an open online collaborative platform involving innovation actors from the aerospace construction and textilesectors that will serve as a space for sharing best practices and as a matchmaking system for new ideas for innovation and circulareconomy and new collaboration partnershipsfoster crossregional and crosssectoral links with dedicated learning visits in combination with innovation workshops andmatchmakings to establish the seed for collaboration among sectors by identifying potential partners for commercial and innovationcooperation that will ultimately generate growth opportunities for smesincrease resilience of smes by supporting their transition to more sustainable business models financing of a feasibility studyprototyping pilot testing demonstrating procurement of further specialized consultancy services and coaching services that cannotbe provided directly by the project partners an adaptation of business processes option to access to dihs testing facilities theintroduction of new it solutions and social innovation strategiesscaleup support to leverage additional funds in transit will connect successful smes with other initiatives for scaling up theinnovationsin transit will allocate 4 m directly for sme support out of 5m 80 of total budgetin transit partnership will allow to reach directly as cluster members 700 smes 140 large companies and over 150 research facilitiesacross 7 eucountries and indirectly over 5000 smes across 38 countries though euwide networks and european strategic clusterpartnerships
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towards reliable and safe gfr
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gascooled fast reactor gfr is considered as one of the six most promising advanced nuclear reactor technologies supported worldwide by the generation iv international forum and esnii in europe with concepts under development in europe and the usa it excels in versatility combining very high core outlet temperatures and the possibility to close the fuel cycle allowing for very efficient and sustainable electricity and industrial heat production replacing burning fossil fuels the treasure proposal presents a research and innovation action aiming at connecting european developers of gfr demonstrator allegro v4g4 centre of excellence with expert organizations with experience in gfr and htr research who will utilize their unique expertise and knowledge and bring fresh ideas to the gfr development it is divided into 6 work packages four of them dealing with open research and development problems of gfrs namely the core operation and safety optimization wp1 experimental validation of the dhr concept wp2 gfr as industrial heat and power source wp3 enhancing gfr safety wp4 dissemination and outreach activities are included in wp5 alongside with communication activities with regulators and relevant international organizations and education and training activities wp6 ensures smooth management and execution of the projectthe main objectives of the treasure project arefurther optimization of the gfr fuel design and fuel cycleexploring possibilities to further reduce produced waste and to further enhance proliferation resistance in gfrsallegro safety concept demonstration including largescale experimental verificationoptimization of operation flexibility and performance of gfrs using intermediate heat storage system cogeneration and hydrogen productionfurther enhancing allegro safety via use of passive and redundant safety systemsattracting students and young professionals to work on gfr development
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complex contagion of childcare strategies amongst lowincome parents
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background high quality childcare greatly improves outcomes in later life yet childcare access and usage are distributed unevenly leading to amplified inequalities in later life outcomes parents from lowincome households are 50 less likely to use formal childcare services than highincome households and use them when the child is older and less intensely research has shown that cost location and quality of childcare effects usage yet policy solutions aimed at removing these barriers have not reduced inequalities in usageaim in this project sociological economic demographic and social policy perspectives are synthesized within a framework of complex contagions to investigate how the use of formal childcare diffuses across low income populations with the aim of identifying barriers to uptake in formal childcareapproach this project breaks through the state of the art to more clearly describe why some childcare strategies that use formal childcare dont spread to low income households with a complex contagion people only adopt a new behaviour if they are repeatedly exposed to it from multiple diverse actors in their network low income households have personal networks with long weak ties and high multilayer clustering that make adopting new childcare strategies unlikely this project therefore examines how the childcare strategies present in work family and neighbourhood networks influences the childcare strategies of low income householdsinnovation impact the analysis will draw on unprecedented linked administrative and survey data to study the diffusion of childcare strategies network data are used in combination with multichannel sequence analysis and other longitudinal methods to identify the role of networks in shaping childcare strategies the project will completely reframe our understanding of not only childcare strategies but also parallel areas of social policy and the wider study of behaviour diffusion in
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the genetic basis of host resistance and pathogen virulence in the septoriawheat pathosystem
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increasing agricultural sustainability has become more than ever a priority in this sense wheat plays a central role in eu agriculture as a major crop and controlling yield losses due to diseases can be a serious bottleneck for agricultural sustainability septoria tritici blotch stb caused by zymoseptoria tritici is a globally occurring fungal disease that causes severe yield losses on wheat and is the source of a massive fungicide applications in the eu furthermore z tritici populations evolve rapidly and their adaptation to the proposed control measures monogenic resistance fungicides is a wellknown phenomenon thus breeding polygenic stbresistant varieties is timely and represent the most durable and economic way to limit disease epidemics and reduce fungicide dependecy however this cannot be achieved without a thorough understanding of hostpathogen interactions and an extensive knowledge of 1 host resistances and their effectiveness in pathogen populations 2 pathogen virulence factors and mechanisms of overcoming host resistance the research proposed here the genetic basis of host resistance and pathogen virulence in the septoriawheat pathosystem septowheat aims to address these gaps by using stateoftheart genomics and genetic resources to meet the challenges of stb resistance breeding and pathogens rapid adaptation the project will be articulated in three integrated objectives 1 genetic mapping of novel resistance locigenes from diverse tetraploid wheats 2 identification of the corresponding pathogen avirulence genes and 3 development of diagnostic molecular assays to accelerate resistance introgression into elite prebreeding material septowheat will have numerous outcomes on durable stb resistance reducing fungicide use within the eu and will significantly contribute to our understanding of hostpathogen genetic in an important agricultural system
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using museum specimens to understand mushroom population genomics
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museum collections and other repositories contain a vast amount of specimens associated with metadata detailing the locationhabitat and ecological observations of the specimen at the moment of collection since these specimens are biological tissues dnasequencing techniques can be used to study them however their application to fungi is still very limited one of such applications ispopulation genomics a field where fungal study is also severely lagging behind that of plants and animals the combination ofsequences from museum specimens and fresh material will allow us to study populations of two mushroomforming fungitrichaptum abietinum and phelopillus nigrolimitatus t abietinum is an abundant species that is emerging as a model for population studies with abundant information in scandinavia museum samples will allow us to detect potential changes in selective forces that have affected norwegian populations mainly associated with landscape changes over the xxth century p nigrolimitatus is a scandinavian nearly threatened species whose populations have been dwindling in association to land usechanges museum samples will allow us to compare past and current genetic diversity of norwegian populations which will helpinform conservation efforts the project will generate snp chips which will help future population and conservation studies by providing a reliable and costefficient analytical tool musheum will combine population genomic data with specimen metadata and ecological information to study selective pressures in the two species finally musheum will make use of the combined genome skimming data generated for the design of snp probes to generate de novo genome assemblies of the two species this advances will allow to repurpose data from population studies for the generation of reference assemblies
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a principled plan to prevent transient execution attacks
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ghostbuster is a research program to stop advanced transient execution attacks which by themselves already rank among the most advanced attacks everby finding vulnerable code fragments analyzing them for exploitability and injecting mitigations where needed the vulnerabilities such as spectre meltdown and others originate in vulnerable hardware and allow data leakage across all security boundaries recently my team and i showed that even more advanced attacks exist by combining transient execution with traditional software exploitation today we have no way of even detecting these hybrid attacks let alone stop them while we keep finding new variants vendors have indicated that they cannot fix them all as it would cripple performance the hope is that developers identify and harden vulnerable code snippets eg with instructions that stop transient execution unfortunately finding vulnerable snippets is hard beyond the abilities of top programmers and even more so for the new hybrid attacks can it be done automaticallythe challenge is daunting and involves all interaction between the code and a myriad of obscure cpu resources requiring expertise in hardware operating systems fuzzing program analysis etc stateoftheart and limited tools do not even aim for mitigation and simply report potential issueswith many false positives and negatives unlike existing solutions that detect the snippets through pattern matching ghostbuster takes a principled approach and considers the fundamental conditions enabling attackswithout resorting to say symbolic execution which scales poorly to large programs it models the fundamental conditions of steps of an attack in terms of control dataflow properties and translates the models into detectors after detecting the code that looks vulnerable it runs additional possibly heavyweight exploitability analysis and if need be mitigates the issue by removing some of the enabling conditions
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democratising and making sense out of heterogeneous scholarly content
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scilakes mission is to build upon the openaire ecosystem and eosc services to a facilitate and empower the creation interlinking and maintenance of scientificscholarly knowledge graphs skgs and the execution of data science and graph mining queries on top of them b contribute to the democratization of scholarly content and the related added value services implementing a communitydriven management approach and c offer advanced aiassisted services that exploit customised perspectives of scientific merit to assist the navigation of the vast scientific knowledge space in brief scilake will develop support and offer customisable services to the research community following a twotier service architecture first it will offer a comprehensive open transparent and customisable scientific datalakeasaservice service tier 1 empowering and facilitating the creation interlinking and maintenance of skgs both across and within different scientific disciplines on top of that it will build and offer a tier of customisable aiassisted services that facilitate the navigation of scholarly content following a scientific meritdriven approach tier 2 focusing on two merit aspects which are crucial for the research community at large impact and reproducibility the services in both tiers will leverage advanced ai techniques text and graph mining that are going to exploit and extend existing technologies provided by scilakes technology partners finally to showcase the value of the provided services and their capability to address current and anticipated needs of different research communities four scientific domains neuroscience cancer research transportation and energy have been selected to serve as pilots for each the developed services will be customised to accommodate differences in research procedures practices impact measures and types of research objects and will be validated and evaluated through realworld use cases
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bioeconomy and circular economy fair network digitally fair and accessible network for reducing ghg activities with circular and bioeconomy models
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bioeconomy and circular economy fair network biofairnet is designed to support hotspots and specific value chains heavily reliant on greenhouse gas ghgintensive industries into leaders of a sustainable biocircular economy via a digital cooperative network the network understood as a digital platform and stakeholder engagement maps informs transfers knowledge and provides an exchange of communication among stakeholders to support their ecological transition the following is achieved through instances of cocreation testing and validation the final product is constructed with those majorly involved aiming to close the gap on this topic between experts public administration businesses and other stakeholders the project is a deep dive into two sectors agriculture and mining and using a cocreation process describes the current practice envisions in both practical social and economic terms what these sectors will look like posttransition and then maps a pathway to get there the insights and tools required to support this pathway will be translated into a webbased transition tool that is both developed and implemented with endusers in fact the final product network identified as biofairnet that this project aims to build wants to be an item created with the stakeholders themselves
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supramolecular photocatalytic latestage ch functionalization
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organic synthesis is still one of the main limiting factors in drugdiscovery projects traditionally the generation of compounds libraries requires tedious synthetic routes to introduce modifications into the lead compound thus the implementation of new methodologies to modify drugs in a selective way in the late stages of their synthesis is highly attractivein supraphocat project several supramolecular receptors will be provided with catalytic activity and combined with photoredox catalysis to achieve unprecedent asymmetric ch funtionalization reactions with exquisite selectivity using co2 as nontoxic abundant c1 building block this ambitious project will establish new methodologies for ch latestage functionalization of drugs which is a key point towards the development of libraries of compounds according to eu green chemistry insightsthis marie sklodowska curie action will merge the expertise of the host group prof luca dellamico nanomolcat group from university of padova in co2 valorisation methods and photoredox catalysis with the expertise of the fellow on supramolecular chemistry molecular recognition and organocatalysis also this project has been designed to augment and complement the research and transferable skills sets of the fellow and will greatly enhance his career prospects to become a mature and independent scientist through the training and the research results arising the fellowship will be beneficial to the candidate the host institution and european scientific and social environmentthis research will allow a great improvement of the stateoftheart in the construction of active organic molecules through a new powerful and impacting synthetic methodology raising the standing of eu chemistry within this field at a global level hence supraphocat will constitute a significant contribution to the field and will suppose a benefit for synthetic organic chemists pharma agro and finechemicals industries in eu
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patronage and european perspective in brandenburg prussia the painter etcher johann friedrich wentzel 16701729
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eubrand sheds light on a forgotten chapter of europes intellectual and artistic history based on the following research question how did painting contribute to the creation of a visual language of absolutism during the reign of the first prussian king frederick i eubrand fosters research and innovation by combining historical enquiry and augmented reality technology at the very beginning of its life as a nation state brandenburg prussia and berlin in particular experienced the afflux of immigrants artists and masters fleeing france after the revocation of the edict of nantes 22 october 1685 their presence in berlin would change forever the city from a productive social artistic and aesthetic point of view brandenburg had never had before inborn artists the first ones become visible only after the huguenots migration one of them is the first berlinborn painter and etcher johann friedrich wentzel 16701729 whom frederick i king in prussia commissioned the monumental ceiling frescos of the newly transformed berlin castle eubrand emphasizes the importance of migration and movements of people across europe in the creation of an iconography of absolutism functional to fredericks dynastic project wentzels personal and artistic trajectory is exemplary in this respect his activity at the castle will provide the basis for an innovative app for visitors of the newly inaugurated humboldt forum highlighting the forgotten layers of brandenburgs history behind one of the major landmark of todays berlin eubrand speaks in a timely way to the ongoing debate on the restitution of the berlins castle allowing a better understanding of the site it contributes to the denationalization of german historiography and meets the need for accessibility and engaging storytelling in cultural heritage by exploiting the potential of the digital transition for research and curatorial purposes
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compressed sensing for climate a novel approach to localize quantify and characterize urban greenhouse gas emitters
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climate change is a defining issue of our time without significant rapid greenhouse gas ghg emission reductions we will face unpredictable consequences for climate and life to effectively reduce ghgs the emissions must be accurately quantified and unknown emitters found however measuring global ghg emissions is very challenging and hence current emission inventories rely mostly on bottomup calculations which lack accuracy and the ability to detect unknown sourcesin cosense4climate i will use the powerful mathematical theory of compressed sensing cs to revolutionize atmospheric inversion my goal is to develop a method to locate quantify and attribute ghg emitters with unmatched spatial resolution and accuracy cs has been used with great success in signal and image processing by taking advantage of the fact that most signals contain redundancies using cs in combination with domain transformations i will generate accurate high resolution emission fields and reveal unknown sources yet require less data than conventional methods i will develop a cs inversion framework not only for local sensor data but also for satellite data which upon success will lead to a breakthrough in monitoring urban ghg emissions globallyi am best suited to reach this goal i have gathered a unique dataset with my fully automated differential column ghg network muccnet the first of its kind with my rich experience in applying computational fluid dynamics cfd solarinduced fluorescence sif and machine learning ml for estimating ghg emissions i will additionally create a highresolution cfdbased atmospheric transport model a satellite sifbased urban co2 biogenic flux model and a ml method for source attribution based on ratios of ghg and air pollutant concentrationscosense4climate will establish a new standard for ghg emission monitoring and provide groundbreaking scientific methods to help solve one of todays most urgent problem climate change
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dso for digital twins
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dsos for digital twins accelerating the uptake of digital twins of the european electricity grid across europe
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science platform cloud infrastructure for outsize usage scenarios
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the spacious project aims to boost the scientific exploitation of esa mission data by offering a new computational framework for astrophysical research that requires big data and data mining technologies to be employed spacious will raise the competitiveness of the eu scientific community by increasing the big data and data mining expertise and providing easier access to these techniquesto reach this goal spacious aims to combine existing technologies in a new data mining environment to enable the analysis of esa missions data up to a level which is not possible without a dedicated infrastructure the ambition of spacious is to open this platform to the community while at the same time exploiting the data by developing astrophysical research in collaboration with external scientific teamsthe main idea is to facilitate and open the analysis of esa archives to the scientific community in new ways spacious will make the difference by providing access to the data and at the same time providing the infrastructure tools and methods to analyse these data spacious will be the tool enabling big data analysis of esa data products furthermore we expect spacious to make a change by influencing the future way to treat data in space sciencea key part of the project is to produce scientific value publications enhanced data products and knowledge we will face major scientific research data problems challenges whose analysis will be per se a key result of spacious four of these challenges will be defined internally based on the exploitation of the massive gaia and euclid datasets and used to drive the design requirements of the system serving as test cases and technology demonstrators of the big data analytics framework bdaf in a second phase we will open the system to the community through an open call for proposals and will select the most relevant both scientifically and technically challenges submitted for their implementation
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design study for a european infrastructure on advanced genomics technologies
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innovation in the genomics field is extremely intense and requires high upfront investments the toolbox of sequencing platforms with unique features that require specialized training and leverage extensive crossfunctional expertise is rapidly expanding the easigends project evolves from two eu infrastructure projects that have proven to be very successful in providing access to cuttingedge dna sequencing technologies to hundreds of researchers here we propose to carry out a design study for establishing a new european research infrastructure on advanced genomics technologies easigen in order to develop an excellent scientific technological and operational design we will conduct landscape studies stakeholder consultations and community surveying in parallel we will seek for the support and commitment of several national and eu stakeholders and user communities through a multifaceted dissemination plan we envision that easigen will encompass 1 a technology platform that will offer stateoftheart genomic analysis methods such as singlecell genomics spatial genomics and longread sequencing as well as populationscale genomics capacity and 2 a support platform that will provide standardization tools training coinnovation with industry and consulting for smaller facilities including those in widening countries both platforms will serve a vast community of users from the health biomedical and life science fields the consortium brings together 1 a network of eleven genomics facilities with distinct application specialities and an aggregated sequencing capacity of 450000 human genomes per year 2 four partners with specific and crucial expertise data stewardship ethical legal and social implications socioeconomic impact and innovation the new infrastructure will strengthen the european research area promote interconnections within the esfri landscape and boost an innovative biotechnologybased industry
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young international academics postdoctoral programme
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the young international academics postdoctoral programme yia is a career development program proposed by the university of luxembourg unilu to nurture earlycareer postdoctoral applicants to gain momentum in interdisciplinaryintersectoral research yia applicants are international talents willing to propose and realize their own interdisciplinary research projects through a bottomsup approach yia will welcome in two calls a total of 10 postdoctoral fellows with 36month contracts over 5 years yia is open to all disciplines and sectors involving unilu in the drive towards an increased interdisciplinarity and intersectorality which are strategic for unilu for the country and for europe a unique aspect of yia is its integration into unilus institute for advanced studiesluxembourg ias created in 2019 to promote interdisciplinarity and outreach towards the society this integration provides the yia fellows with 1 a supervision for interdisciplinary and intersectoral research with more than 350 potential cosupervisors and with about 350 potential publicprivate partners 2 peer and crossgenerational interactionsmentoring through the ias fellows invited distinguished senior scientists early career researchers and a mandatory academic or industrial secondment and 3 a truly international flavour in an environment that cherishes diversity and excellence yia fellows recruited at unilu are offered competitive contracts with mobility fellowships and access to excellent research infrastructures a professor of unilu provides supervision for the primary discipline of the applicants project and a cosupervisor covers the complementary disciplinesector the yia fellows are offered an la carte training including mandatory courses to suits the fellows career aspirations increase the fellows interdisciplinarity and employability the yia programme will support a rapid ramp into a longterm unilu funding of postdoctoral ias fellows
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social and human centered xr
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the social and human centered xr sun project aims at investigating and developing extended reality xr solutions that integrate the physical and the virtual world in a convincing way from a human and social perspective the virtual world will be a means to augment the physical world with new opportunities for social and human interactionwe will address the following limitationslack of solutions to develop scalable and costeffective new xr applicationslack of convincing solutions for mixing of the virtual and physical environmentlack of plausible and convincing human interaction interfaces in xrbarriers due to resource limitations of enduser deviceswe will develop solutions to surpass current limitations includingdevelopment of scalable solutions to obtain plausible and convincing virtual copies of physical objects and environmentsdevelopment of solutions for a seamless and convincing interaction between the physical and the virtual worlddevelopment of wearable sensors and haptic interfaces for convincing and natural interaction with the virtual environmentdevelopment of artificial intelligencebased solutions to address current computing memory and network limitations of wearable devicesthe developed solution will be demonstrated in three reallife scenarios1xr for rehabilitation after accidents or diseases2xr in the industry to increase safety and improve social interaction among workers3xr to remove interaction barriers for persons with disabilities
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making old objects valuable again the cultural economic challenges and sustainability opportunities of antiques in the 21st century
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what do old porcelain wooden furniture and silverware have in common all of these antiques fall into the category of informal heritage regardless of their cultural significance many of these objects remain on the margins both in cultural institutions and scholarly research as a result the question of how antiques are safeguarded valued traded perceived and consumed remains largely underexplored by studying the contemporary economy of antiques moovas prime objective is to highlight the potential of these objects regarding the safeguarding and promotion of informal heritage sustainable consumption new business models for ageing sectors and local city development more specifically moova aims to 1 demonstrate the patrimonial role of antique dealers as vital safeguarders of informal heritage 23 explore the market structures at play within the antiques trade its economic impact and the supply and demand for antiques in a digital economic context 4 understand how antiques are perceived by younger generations gen z and 5 develop a theoretical and practical model for renewing the meaning and value of these complex objects through selected case studies european decorative arts and a multitransversal approach crossmarkets objects countries the project will combine theories data and methods from art history cultural economics cognitive science and arts marketing to investigate this topic holistically the first stage will consist in data collection and processing using new databases of evidence drawn from primary and secondary sources incl interviews and sales results while the second will be dedicated to the development of the reevaluation model moovas overreaching goal is to progress towards more advanced scholarship in art market studies by providing tools that better fit the idiosyncrasies of markets for complex cultural goods and to address issues related to art education audience renewal and job opportunities
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overnight vulnerable emotion reset normalizing invalidating generalized hyperaroused tension
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anxiety and insomnia account for onethird of the global mental health burden prognosis is poor chronicity and relapse are common because treatment effectiveness is moderate while this situation calls for treatment innovation the required knowledge on targetable key mechanisms is lackingtheir shared core symptom is hyperarousal covering subjective physiological and clinical indicators hyperarousal is not just another overlapping symptom individual differences in hyperarousal determine severity prognosis and treatment response across insomnia anxiety and stressdisorders hyperarousal links their genetic and phenotypic overlapsince hyperarousal plays such a pivotal role in the development and chronicity of these disorders a transdiagnostic mechanistic understanding of hyperarousal would have major implications for the direly needed development of better treatment this project aims for a transdiagnostic mechanistic understanding of hyperarousal across wake and sleep and use to this insight to innovate treatmentthe project will do so by combining largescale datadriven approaches with targeted testing of the novel hypothesis that hyperarousal may be reset overnight crossing disciplines and diagnoses the project will first deliver an integrated account of the subjective brain structural brain functional and physiological hyperarousal landscape this approach will deliver unprecedented transdiagnostic insights into the lifetime development and underlying brain mechanisms of hyperarousal vulnerability and its consequences for mental health moreover this approach will yield both innovative stateofthe art tools as well as practical tools to quantify hyperarousal these tools will be employed in both experimental preclinical studies and immediately applicable transdiagnostic clinical interventions expected to considerably improve the perspectives of people suffering from the most common mental disorders by alleviating hyperarousal overnight
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green innovations in hydrogen for sustainable energy transition
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the h2start project aims to establish a centre of excellence coe in stara zagora to spearhead the advancement of innovative technologies for renewable hydrogen production and uptake as an essential component of the transition towards a lowcarbon and energysecure economy renewable hydrogen holds tremendous promise for bulgaria particularly in regions like stara zagora historically developed as the energy production heart of the region economically developed and well connected to infrastructure and transeuropean roadsthe coe situated in the heart of stara zagora is strategically positioned to lead the change in replacing coal mining with renewable energy and green hydrogen production deployments and export recognised as a hydrogen valley by the clean hydrogen partnership zahyr hv the regions successful transformation hinges on excellence ri activities attracting talents and gaining recognition and international collaboration led by tru and supported by bgh2a the coe aims to drive ri initiatives which will bring institutional change to the higher education sector in the whole system opening up to reforms linked to creating highly skilled employment opportunities and positioning bulgaria as an attractive hub for scientific and technological advancement collaboration with esteemed partners such as polito and cnr alongside the guidance of international recognized leaders will ensure robust governance management and administration systemsthe coe will revolutionize bulgarias research ecosystem offering modern infrastructure and services to attract nurture and retain research talent while fostering collaboration with industry for enhanced innovation and technology transfer as bulgarias research infrastructure outside of the capital sofia the coe in stara zagora will serve as a beacon for bringing ri in regions positioning the nation at the forefront of clean energy transition technologies based on renewable hydrogen production
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fair food and trade systems for africa through food convergence innovation
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the fci4africa project champions a holistic approach to african agriculture promoting fair sustainable climateneutral and healthpromoting trading practices while ensuring economic prosperity at all levels and respecting human rights it bridges the gap between technical compliance and social justice by empowering smallholder farmers and small and mediumsized enterprises facilitating trade compliance through a digital platform and enhancing food safety by evaluating the impact of certification criteria like deforestationfree organic and fair trade and guiding policymakers fci4africa fosters a just transition for african farmers processors and traders expanding their intraafrican and eu trading opportunities leveraging past projects and cuttingedge technologies fci4africa connects stakeholders across diverse regions and jurisdictions paving the way for a more sustainable and equitable african agricultural sector
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the politics of wildfires a comparative study of norms power and conflict in the global south
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extreme wildfires have been on the rise across the globe due to climate change and other human actions despite the abundant literature on fire ecology and a recognition of the linkages of wildfires to global warming a patchy understanding of the relationship between fire and anthropogenic actions and their political drivers persists social sciences scholarship has mostly focused on fire mitigation and management in the global north while complex relationships between societies and fires in the global south remain broadly unexplored these two gaps in the academic literature in terms of scope and geography are reflected in a narrow public understanding of wildfires as risks and natural disastersfirepol goes beyond the state of the art by leading the most rigorous crosscontinental study of the political drivers of wildfires in the global south through a radical multimethods approach and a comparative perspective my team and i will combine and analyse newly compiled fire policy and remote sensing data with qualitative case studies and ethnographic research the aim will be to understand and explain how a range of political factors linked to formal policies and institutions actordriven power dynamics and social contention shape the geographical distribution and social impact of wildfires and public narratives about them firepol is an ambitious highriskhighgain project that will deliver a new framework to understand and explain the connections between politics and wildfires at a timely moment when wildfires have been identified as crucial socioecological challenges within the global climate change agenda it will develop a new theoretical framework around the concept of wildfire commons as a way of engaging the academic community policy stakeholders and the general public in the coproduction of alternative pathways for the sustainable equitable and politically engaged management of wildfires
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derisking the drug discovery process of oncology and metabolic diseases
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excellence vitala technologies brings together organonchip ooc hyperpolarized magnetic resonance spectroscopic imaging hp mrsi and advanced data analysis tools to provide a patented and revolutionary test for the monitoring of the efficacy in treatment of a new drug moving through the metabolic pathways of a cell this new methodology provides the opportunity to set preclinical drug testing strategies that are more effective faster cheaper and reduce animal use the information obtained by this novel methodology will improve the future steps for drug candidates in advanced preclinical and clinical stages vitalas analysis allows defining and executing on preclinical testing strategies increasing the speed of the drug discovery process and reducing its costsimpact an increased accuracy in the early stages of the drug screening process will allow discarding inadequate pharmaceutical candidates before those reach the animal testing stage reducing the number of animals used in the whole preclinical process moreover our objective is to derisk and revolutionise the entire drug discovery process decreasing the direct and indirect costs associated with the preclinical drug discovery pipeline with our realtime nondestructive highly sensitive technology vitalas impact will expand to later phases of drug discovery by preventing invitro and in vivo as well as human testing of drugs that in the absence of translatable models could have been deemed appropriate to proceed to later clinical trial stagesimplementation and team vitala is formed by a management team of professionals with complementary backgrounds in the fields of microfluidics imaging technologies and business administration vitala has already filled a pct patent application and successfully completed an fto which gives our technology a green light to be exploited both in the eu and the usa with short and long term strategies in place
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accelerated additive manufacturing digital discovery of a new process generation
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additive manufacturing am by laser powder bed fusion lpbf has the potential to revolutionize future product development design and supply chains since the underlying multiscale physics are not well understood its potential can presently not be exploited suboptimal process conditions lead to severe defects on different scales rendering parts unsuitable for use critically known regimes of stable processing go along with very low built rates ie very high costs compared to other processes this limits lpbf to selected high value applications such as medical devices but prohibits applications in mass production where it otherwise could allow for entirely new technologies excelam aims at the digital discovery of novel highthroughput process regimes in lpbf to increase build rates by at least one order of magnitude computational modeling would be perfectly suited for this purpose since it allows to observe physics that are not accessible to measurement and to study novel process technologies that are not feasible with existing hardware unfortunately existing computational tools are by far not powerful enough given the complexity of lpbf therefore excelam will develop novel gamechanging methodologies grouped into two main classes first novel highfidelity multiphysics models will be developed capturing the complex multiscale nature of lpbf these are combined with cuttingedge high performance computing schemes allowing for predictions on unprecedented time spans and system sizes second novel databased learning approaches will be developed to enrich the physical models with process data while exploiting the manifold of existing data as effective as possible based on these cuttingedge tools excelam will push the limits of lpbf moreover by making them publicly available excelam will help scientists and practitioners in the field of production engineering and beyond to face the technological challenges of the 21st century
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philosophy of social physics
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philosophy of social physics sophy intends to explore the impact of physics on the genesis of the social sciences and to define the current use of social physics in the scientific discourse on big data related to crowd behaviors the general hypothesis is that physical narratives and notions such as force resistance balance and average have played a crucial role in shaping the concepts we use to think of society since the rise of the sociological thought in the 19th century and that in reconstructing the genealogy of the social sciences the reference to natural sciences cannot be limited to the biological frameworkthe goal is to provide new insights into the conceptual paradigms that have been underpinning democratic governance in modern and contemporary societies thus raising awareness about the rationale of increasingly databased patterns in social policies the social physics paradigm has not yet been analysed in depth through a politicalphilosophical perspective capable of showing the internal logic and history of the concepts employed additionally an analysis of the links between physicsrelated notions and political and social concepts in the 19th century is still to be outlined moreover there is still no historical conceptual and philosophicalpolitical study focusing on the origins of social physics as it is understood and structured todaysophy will use a methodology resulting from an original combination of the tradition of begriffsgeschichte foucauldian discourse analysis historical epistemology and history of social concepts this methodology will allow to analyse the historical semantics of concepts emphasizing their contingency and their cultural and social constructed nature while defining at the same time the epistemic structure in which they are produced and used
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joint sensing and communications for future interactive immersive and intelligent connectivity beyond communications
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the instinct project is going to enable globally sustainable interactive immersive and intelligent beyond communications 6g connectivity by developing three complementary but critical breakthrough technology pillarssensingassisted communication technologies thus allowing localization tracking mapping monitoring imaging incident detection and semantics become integral parts of connectivity services pillar 1intelligent surfaces holographic radios and cell free systems which offer wavefront engineering functionalities and tuneability of the wireless environment and can act as reconfigurable and intelligent sensors pillar 2 andmachine learning ml techniquesbased codesign of sensing and communications instinct proposes a revolutionary path to 6g and has the ambition to specify the relevant kpiskvis formulate suitable models devise the theoretical framework invent new technologies evaluate via simulations and validate by means of 2 hw and 1 sw demonstrators a networked intelligence concept able to meet the unprecedented 6g requirements to realise this vision instinct consortium brings together all relevant stakeholders from across europe with an impressive record of interdisciplinary research excellence technology innovation standardisation and transfer and implementation expertise
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boosting ingenium for excellence
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the bi4e project is born out from the ingenium alliance of european universities with the ambition of enhancing the existing interuniversity cooperation between the partner universities as well as with other entities both international and local and to strengthen the higher education institutions heis capacity to meet the diverse challenges faced by the higher education system and institutions the twin green and digital transition the fight against climate change the achievement of the agenda 2030 sdgs all of them profound societal challenges the universities must be ready to address the bi4e project intends to give a boost to the alliance making it an effective instrument to promote excellence in the partner heis particularly targeted to the alliance members in the widening countries the gheorghe asachi technical university of iasi and the medical university sofia and involving leading heis from six different member statesthis bi4e project is particularly focusing on the research and innovation missions completing the strategic and operational capacities of the partners especially those from the widening countries bi4e activities will directly touch six out of the seven transformation modules proposed by the policy report towards a 2030 vision on the future of universities in europethe project will improve hei capacity to address major challenges through the implementation of strategic planning adapted to their needs institutional transformation cooperation in terms of research fostering entrepreneurship and the promotion of international scientific careers the project will help to build closer cooperation links between the partners that will facilitate the exchange of information knowledge and experience at the end of the project the alliance will be much more prepared to become a fully operational european university alliance in which cooperation in education and research will be carried out seamlessly
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miniaturized plasma emission spectroscopybased breath analysis for unobtrusive athome monitoring and prediction of copd exacerbations
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patients suffering from chronic obstructive pulmonary disease copd suffer from persistent airway obstruction causing shortness of breath and extreme fatigue patients are repeatedly hospitalized due to acute flareups known as exacerbations which are largely responsible for the morbidity and mortality associated with copd exacerbations are diagnosed based on symptoms only and diagnosis is often too late there is an urgent need for a reliable technology for unobtrusive and continuous athome monitoring of copd patients to enable timely exacerbation prediction and treatment the breathsense consortium aims to develop the firstever handheld breathalyzer for noninvasive detection of breath biomarkers respiq has developed a breakthrough plasma emission spectroscopybased breath analysis technology and will collaborate with sensor development expert sintef userexperience and cocreation expert nell and clinical copd specialist kcl the consortium will combine innovative technological advancements with humancentric userexperience research to develop and validate a transformative clinical workflow for athome monitoring of copd patients with this digital biomarkerbased monitoring solution patients and clinicians will benefit from reliable and timely prediction of exacerbations leading to early treatment intervention and preventing up to 95 hospitalizations the breathsense workflow will deliver a paradigm shift in copd management from symptombased delayed diagnosis towards preventative athome monitoring prior to symptom worseningultimately the breathalyzer technology is a platform technology that can be applicable for a wide range of respiratory and gastrointestinal diseases that could also be monitored better continuously at home such as asthma lung cancer and ibs since novel biomarkers can be incorporated for different disease indications as such the breathsense technology has the potential to improve the health of millions of people
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Aşağıdaki prompt'a uygun bilimsel bir yanıt üret.
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beyond influence the connected histories of ethiopic and syriac christianity
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the innovative beinf project interrogates the connected histories of ethiopic and syriac christianity in their various complexities and nuances it accomplishes this task through a series of five discrete but complementary case studies addressing 1 aramaic loanwords in ethiopic 2 the socalled nagran episode in which the sixthcentury aksumite ruler kaleb intervened on behalf of syriac christians who were being persecuted in the arabian peninsula 3 the ethiopic abba grima gospels including especially their illumination programs 4 the hagiography of the nine saints who are alleged to have brought about a second christianisation of ethiopia in the late fifth and early sixth centuries 5 the ethiopic reception of syriac literature beinfs innovation is multifaceted it adopts a multidisciplinary approach that brings together methods that are traditionally categorized as distinct and disconnected including especially art history linguistics manuscript studies philology textual studies and history in addition it rejects area studies and unites fields that have traditionally been isolated and siloed off in problematic ways finally it proposes to move beyond influence as an analytical category for analysing connections contacts exchanges and the actors and cultural brokers responsible for them and instead adopts a methodological and theoretical stance inspired by connected history especially in the sense of histoire croise with these innovations beinf is positioned to make significant longlasting contributions to the field of ethiopic studies both in content and in concept while also serving as a paradigmshifting model for other projects in the humanities addressing areas of inquiry that have traditionally been dominated by illframed questions of influence and that are primed to move beyond influence to explore connected histories with all their nuance complexity and texture through a multidisciplinary approach
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resilient multimodal freight transport network
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remunet identifies and signals disruptive events and assesses their impact on multimodal transport corridors it reacts quickly and seamlessly upon disruptive events in realtime it supports tmsproviders to improve route planning resilience remunet communicates alternative predefined multimodal transport routes to logistics operators and subsequently to truck drivers locomotive drivers and barge captains through this it enables a faster and adaptive multimodal network response remunet orchestrates route utilization suggests transshipment points and optimizes capacity allocation minimizing damage and shortening the recovery time what is remunets core objectiveas trailblazer for the physical internet remunet pursues the vision to enable and incentivize synchromodal relaytransport on european rail road and inland waterways to increase the holistic network resilience it significantly reduces emissions and boosts freight transport corridor efficiency in case of disruptive events how will remunet achieve this1a standardized method to describe multimodal transport networks the proposed standard is derived from existing approaches and developed together with critical stakeholders to ensure europewide practicability and acceptance2an algorithm capable of calculating multimodal route alternatives and capacity utilization in the face of disruptive events it uses realtime data for dynamic synchromodal alternative route planning 3a collaborative platform connecting relevant freight operators and enables them to manage disruptions this is done by providing secure and resilient digital logistic and network management tools enabling alternative route planning information and orchestrating eventbased synchromodal relay transportation 4using reinforcement learning to model and evaluate alternative courses of action providing the basis for a selflearning adaptive multimodal european freight transport and logistics network
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autonomous learning agents in physics
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in recent years the use of machine learning ml for the study of physics has experienced a strong boost however most of the machines used are black boxes and the causal relation between inputs and outputs is often impossible to extract nonetheless a critical aspect when dealing with physical systems is not only to make correct predictions but to understand the physical laws which underlie these assessments recently an increasing number of works aim at developing interpretable ml methods from which such hidden laws can be extracted however their application to physics has been often limited to supervised and unsupervised learning approachesthe aim of this project is 1 construct an interpretable reinforcement learning method 2 extract hidden rules and features in timely and paramount problems in physics the method combines three wellestablished concepts of ml projective simulation graph neural networks gnn and hidden variable disentanglement ps provides interpretable rl agents that can be trained for a variety of tasks from the construction of quantum experiments via skill acquisition in robotics to the modelling of honeybee colonies by enhancing their learning power and interpretability with gnns and variable disentanglement we will extract the hidden features of the systems the rl agents have interacted with and ultimately the physical laws governing them in particular we will tackle problems in the field of condensed matter where particles diffuse either passively or actively to reach a target state moreover we will consider ensembles of rl agents so as to analyze not only the physical properties of the systems but also their interactions and communication dynamics in the quest of a common targetthe originality of the proposal is directly related to 1 the methods that will be developed 2 the systems of study 3 most importantly the information we will access and discover with the interpretable rl agents
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global estimates for nonlinear stochastic pdes
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the project is concerned with the global behaviour of solutions to stochastic partial differential equations spdes from mathematical physics which arise eg in the description of scaling limits of interacting particle systems and in the analysis of quantum field theories the equations contain noise terms which describe random fluctuations and act on all length scales in this situation the presence of a nonlinear term can lead to divergencies a subtle renormalisation procedure which amounts to removing infinite terms is needed over the last years the understanding of nonlinear spdes has been revolutionised and a systematic treatment of the renormalisation procedure has been achieved this led to a shorttime wellposedness theory on compact domains for a large class of highly relevant semilinear spdes in this project i will describe the global both in time and over infinite domains behaviour of solutions of some of the most prominent examples by combining pde techniques for the nonlinear equations without noise and the improved understanding of the subtle smallscale stochastic cancellations i have already pioneered such a programme in an important special case the dynamic phi4 model the project has three specific strands a proving estimates for the stochastic quantisation equations of the sinegordon and liouville quantum gravity models and eventually gauge theories and to giving a pdebased approach to the celebrated 123 scaling of the kpz equation b giving pdebased constructions of phi4 models in fractional dimension and describing phase transitions in terms of mixing properties of the dynamics c treating degenerate parabolic equations and exploring if systems that fail to satisfy a fundamental subcriticality scaling assumption can still be treated using spde techniques
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participatory algorithmic justice a multisited ethnography to advance algorithmic justice through participatory design
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ai comes with great promises but more critically it comes with demonstrated harms from racial and gender bias to discrimination wrongful arrests defamation surveillance or the extractive labor and practices required for its creation i contend that the most concerning aspect of ai is the exacerbation of existing structural inequalities and creation of new ones two prevailing responses have emerged to the social and ethical problems of ai ethicists and social scientists have focused largely on principlebased approaches and developers have focused on technical fixes for addressing problems in ai models this project speaks to an urgent gap between these approaches it centers the experiences of marginalized communities and develops interventions into ai concerns that are designed by and for those communities this project develops the novel approach of participatory algorithmic justice participatory algorithmic justice defines a concept and standards of practice for collaborative research to better understand who and what ai harms but also how these harms should be redressed the project investigates how economic cultural and political harms from ai are experienced by structurally marginalized groups through multisited intersectional ethnographic fieldwork this fieldwork informs participatory design workshops to develop specific interventions into problems identified by research collaborators this research is brought to life through an innovative combination of graphic storytelling and a publicfacing mapping platform participatory algorithmic justice brings the voices priorities and concerns of those affected by ai to the forefront of debates over what kinds of ai people want to live with tackling a critical problem of global technology justice this project is a crucial intervention for communities researchers and developers to redress ai harms
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giving voice to hispanic chant through a phylogenetic study of medieval plainchant
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plainchant the sacred christian chant is the most ancient western corpus preserved in musical notation before the unifying adoption of the gregorian liturgy throughout europe in the 9th century a number of liturgical families each one with its own chant repertoire emerged in the ancient western roman provinces among them the hispanic liturgy was recorded text and music in manuscripts between ca 700 and ca 1300 these sources allow us to know the liturgys ceremonies and texts but not the melodies themselves in fact notational signs do not indicate the specific intervals between the notes since they were written prior to the use of a notational system in which each individual sign contains precise pitch information as a consequence the hispanic musical notation is considered indecipherable and its thousands of melodies still remain silentresound aims to achieve what has so far been considered an impossible task bringing to life the sounds of hispanic chant to accomplish this goal we will use tools from the fields of bioinformatics genetics computational analysis aural architecture and virtual restoration of sound and images along with tools from the humanities including musical performance computational analysis aside these tools have never been used in the study of medieval chant let alone in combination by recovering the sounds of hispanic chant and establishing these innovative methods we will be able to offer new understandings of the generative and evolutionary dynamics of the european plainchant repertoires in this way we will not only recuperate the hispanic melodies but also restore a significant part of the soundscape of medieval europe thus by reversing the standard approach via focusing on a territory considered peripheral we will shed new light on the process of cultural creation in the european middle ages
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liberation analysis for optimizing extraction and processing of crms
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the crm act together with other eu policies towards the green and digital objetives of the ce and the eu current context pose some challenges and needs to the extractive and processing industries improve and facilitate access to raw materials and reduce eu dependency increase circularity ensure recycling into secondary raw materials and recovery from extractive waste ann also the mining and processing industry must be sustainable thus competitive socially responsible and efficient in terms of cost reducing energy consumption and gas emissions bloom aims to develop and demonstrate extraction and processing technologies to facilitate exploitation of the primary raw critical raw materials for this th ecollaboration with both ukraine and canada is envisioned 2 and 3 partners from these countries respectively clustering activities are envisioned through key partners and a a business case and exploitation strategy bloom will tackle the challenges through its strategic objective which is to facilitate exploitation of the primary crm minerals and metals only for the eu to strengthen the eu supply chains by increasing the efficiency on extraction and processing with a smart and modular solids analysis system consisting on an online mineral liberation analysis which enables the integration on mining sites of advanced control loops in different stages of the processing based on ml and ai techniques or datadriven extraction operations based on accurate mineralogy information from the site these actions are oriented to lowering the costs of extraction and processing increasing the financial viability thus also contributing to making profitable lowgrade deposits giving access to new suppliesbloom consortium is composed of a multidisciplinary group of 15 partners from 4 european countries 2 from ukraine 3 from canada and 1 from brazil one of the resourcericher countries in the world and lead by upc
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universal prevention of maternal perinatal mental disorders and its implementation as normalized routine practice
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maternal mental disorders are the most common complications during pregnancy and within the first year after childbirth defined as the perinatal period and are the leading cause of maternal suicide affected mothers cannot function properly causing a devastating impact on the entire family effective primary prevention interventions are urgently needed however the current scientific evidence is insufficient to implementing primary preventive programs at the population leveli aim to establish the effectiveness of universal preventive interventions for maternal perinatal mental disorders and to support their implementation as normalized routine practice in global healthcare services integrating classical and emerging methodological frameworks family systems selfdetermination theory and normalization process theory as well as the perspective of patient and public involvement in research i will a develop a personalized mobilehealth preventive intervention for mothers and their partners which integrates evidencebased psychological components and personalized health recommendations b test preventive intervention effectiveness for reducing the incidence of maternal depression and anxiety disorder reducing fatherpartner symptoms of depression and anxiety and promoting child health and development c apply a causal methodology to pinpoint the underlying mechanisms for the effectiveness of the preventive intervention and d understand the implementation process and identify the factors that can promote or inhibit implementationwith the multidisciplinary team that i lead and a largescale hybrid effectivenessimplementation trail in realworld maternal health services this research programme promises to be the first in its field the resulting robust scientific evidence and novel explanatory model will create a new research paradigm a toolkit for implementation research will enhance translation as normalized routine practice
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rylenediimidebistriazinyls synthesis characterization and magnetic properties
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polycyclic aromatic hydrocarbons pahs with stable openshell groundstates are needed for stateoftheart applications eg organic spintronics electronics energy storage etc herein we propose rylenediimides naphthalenediimide ndi perylenediimide pdi as promising pah scaffolds for building multifaceted blattertype diradical conjugates that are typically inherently stable but also readily prepared the introduction of ering fusion of the triazinyl moiety blattertype promotes planarization and rigidity of the rylenediimide core to allow spin delocalization which electronically stabilizes the rylenediimidesbistriazinyl conjugates dft calculations support the high spin delocalization across the ncnn tetrad triazinyl unit and the backbone ndipdis three rylenediimidemonotriazinyl and two rylenediimidebistriazinyl conjugates will be prepared and studied the latter were selected from dft computational studies of eleven possible ndipdibistriazinyl conjugates owing to low singlettriplet energy gaps 1 kcalmol that indicate potential singlet biradical behavior the triplet states of these conjugates could be accessible by heat or light which will open up the opportunity of having desirable switchable materials the selected five rylenediimidebistriazinyl conjugates will be synthesized via our previously optimized straightforward synthetic protocols after standard characterization magnetic and spintronic properties conductivity and film forming properties will be investigated single crystal xray crystallography epr and squid studies will validate spin states singlettriplet energy gaps and solidstate magnetic properties the project will advance the field of organic electronics
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the role of lasp1 and pdlim4 in stress fiber dynamics and mechanoresponsive signaling
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the lim domain proteins lasp1 and pdlim4 are associated with the actin cytoskeleton and implicated in many diseases however their precise molecular functions are poorly understood recent protein interaction studies from my host laboratory provided evidence that these two proteins associate with stress fibers sfs the contractile actomyosin structures of nonmuscle cells distant homologues of lasp1 and pdlim4 are also present in muscle sarcomeres suggesting a potential structural role of these proteins in sfs however several other lim domain proteins are involved in a widevariety proteinprotein interactions and signaling pathways suggesting possible roles for lasp1 and pdlim4 in signal transduction especially in mediating mechanosensing in sfs indeed previous studies proposed that lasp1 is a possible regulator of translation whereas pdlim4 may function as an adaptor between the cytoskeleton and kinases the aim of my work is to elucidate the molecular functions of pdlim4 and lasp1 using a combination of proteomics cell biological genetic and biochemical approaches my specific interest is to uncover whether pdlim4 and lasp1 are structural components of stress fibers or if they function as mechanosensitive regulators of translation or intracellular signaling the findings will uncover the roles of pdlim4 and lasp1 in cytoskeleton organization potentially providing new insights into various diseases including cancer additionally understanding the interplay between sfmediated mechanosensing and translation may reveal new mechanisms by which cells respond to mechanical cues overall this study will broaden our understanding of sfsignaling and has potential implications for therapeutic interventions in diseases linked to sfdysregulation
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gut microbiotainduced tregs for inflammatoryboweldisease ibd immunotherapy miti2
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our project focuses on the regulatory properties of a subset of microbiotaspecific tr1like regulatory t treg cells for which we have already shown an unprecedented association with the clinical outcome of patients in various inflammatory diseases for a therapeutic use in inflammatory bowel diseases ibd ibd is a disabling chronic inflammatory process that affects young individuals and causes many lifealtering symptoms and represents a risk factor for colon cancer existing treatments are complex with most people requiring lifelong medications as well as dietary and lifestyle modifications and some requiring surgery in this context the development of new therapeutic approaches appears essential and immunotherapy and cellbased therapy are particularly promising strategies for this diseaseteams from nantes have a strong expertise in the field of human immunology mucosal immunology and immunotherapeutic strategies applied to various pathological conditions including gut inflammatory diseases they recently identified a novel microbiotainduced treg subset associated with good prognosis in ibd patients thus representing a promising candidate for innovative immunotherapeutic approaches based on the limitation to develop immunotherapy approach for human diseases by using animal models due to immune system specificitiesdifferences and ethical considerations we opted for the development of an ex vivo human preclinical model that will reconstitute the physiological complexity of the human gut teams from strasbourg have a strong experience and already setup models of organoids in different pathological systems that will perfectly fit to be used as ex vivo preclinical models for this projectthis proposal aims thus at providing a preclinical package including i the proof of concept that a cellular immunotherapy using the identified tregs subset represents a treatment for ibds and ii the reglementary preclinical in vitro and in vivo toxicity
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medieval appetites food plants in multicultural iberia 5001100 ce
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the islamic conquest of iberia in the 8th century brought in profound changes in the political social and economic realms that transformed the everyday life of local rural and urban communities technological innovations and the arrival of new crops impacted their agriculture diet and culinary practicesplants were present in almost all aspects of medieval peoples ordinary lives food crafts medicines etc however they have been commonly sidelined in discussions of the past most of what we know about plants in this multicultural period in iberia is based on a limited number of archaeobotanical studies and on written sources which despite their undeniable value they often reflect issues related to the elites by contrast archaeology and more specifically archaeobotany and their associated sciencebased techniques are placed in an extraordinary position for approaching issues related to plant production processing preparation and consumption and how these connect to broader societal changes by integrating archaeobotany and written sources as well as applying groundbreaking techniques plant genomics and food remains analyses medapp aims to disentangle what range of plants were used in medieval iberia 6th11th ce where new species came from and when were they introduced who brought them and how people engaged with them through different practices the project sets a new holistic agenda for understanding the impact of the new political economic and social system on agriculture eating habits and culinary practices of iberian medieval communities this project aims at providing a stepchange in the way agriculture plant production preparation and consumption have been studied in medieval iberia it represents a golden opportunity to fill the voids of texts looking for clues in the archaeobotanical record an occasion to approach with a suite of scientific and innovative methods the unspoken information contained in these silences
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control of hydrogen and enrichedhydrogen reacting flows with water injection and intensive strain for ultralow emissions
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we are racing against time to find a clean yet abundant energy source able to arrest global warming hydrogen has all the characteristics to address this challenge it can be produced cleanly from water it is incredibly energetic and more importantly it is carbonfree however hydrogens strong reactivity and diffusivity make the control of its flame in energygeneration devices extremely challenging moreover toxic nitric oxides nox a major concern for air quality are still abundantly produced in a hydrogen flame enabling the use of hydrogen requires thus solutions where the flame is stable and with ultralow nox at the same time and at any power settingin this research i will study for the first time the combination of intensive strain and water injection in the context of lean premixed combustion my preliminary research has indicated that intensive strain improves the reactivity of the hydrogen flame and simultaneously pushes the nox down significantly a property yet to be understood water injection further pushes down the nox but it commonly causes flame extinctions and inefficiencies its combination with hydrogen and intensive strain by enhancing the flame offers a way of surpassing these limitations and further allows to operate the flame at richer conditions so preventing common instabilities from occurring in lean premixed combustionthe objective of this research is to push the hydrogen flame into a highstrain regime characterised by stable flame and ultralow nox and find the extreme limits and physical knowledge allowing full control of the reacting flow in such a regime the flame dynamics still unknown in this regime will be explored for the first time and fully characterised in this research by using highfidelity simulations experiments and theoretical analyses the gathered understanding will allow the control of hydrogen flames at any power setting this will pave the way for the exploitation of green energy
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minimisation of the offshore wind and tidal turbine acoustic footprint on marine life
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for renewable energies to be sustainable in the future their impact and harmful effects on the environment should be minimum recent evidences suggest that offshore wind and tidal turbines can have an acoustic damaging impact on marine life due to the sustained generation of noise which propagates very efficiently underwateroffcoustics combines numerical simulations and experiments to provide insights into the physics governing the aerohydroacoustic generation and propagation for offshore wind and tidal farms control of these physics will enable the design of silent offshore farms enabling renewable energy with zero acoustic impact first i propose to develop a novel aerohydroacoustic solver blending advanced high order numerical techniques through machine learning and trained with experiments to simulate flowacoustic signatures for wind and tidal turbines in realistic offshore environments including bathymetry airwater surface etc second an experimental campaign will generate aerohydroacoustic data for scaled turbines and farms to help elucidate the physics governing offshore acoustics and to guidevalidate the flowacoustic simulator third simulations and experiments will be combined to characterise turbines in complex offshore environments and to develop physicinformed surrogate models fourth using the developed surrogate models and optimisation offcoustics will propose new designs of silent farms that minimise the acoustic impact while ensuring energy productionmajor advances in multidisciplinary aspects are expected including fluid mechanics numerical simulations optimisation experimental acoustics aerohydroacoustics and offshore wind and tidal turbine physics
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on rosalyn turecks legacy for bach performance in the 21st century
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js bachs musical legacy is astonishingly rich we have been responding to his music for more than 300 years the american keyboardist rosalyn tureck 19132003 devoted more than six decades to performing researching teaching and writing about bachs works as well as music and arts in general she has left an abundant heritage on performance practice and scholarship for those who seek to understand perform and communicate bachs music this heritage remains mostly unrevealed bringing together efforts from music performance musicology aesthetic social studies new music technologies and composition the tureckbachxxi project aims at gathering exploring and questioning turecks ideas for bach performance in the aesthetic cultural social and technological mindset of the 21st century the main outcome of this project will be a commented edition of rosalyn turecks ideas and findings on concepts performance practices and techniques and stylistic prospects involved in the realization of bachs music and its connections with the music of today this will be useful not only to artist performers but also to musicologists composers and all enthusiasts interested in bachs legacy as well as for the evolution of music and the arts in addition this project investigates musicologicalperformance questions opened by rosalyn tureck that will bring new perspectives to performers as well as to researchers and bach enthusiasts finally the project questions the vitality and the longevity of a music of a past era in the technological cultural aesthetic and social environment of a new music era this will result in particular in a series of interviews with composers of today nourished with questions raised by rosalyn tureck testimonies about rosalyn tureck from the remaining people who worked with her will also be collected this interdisciplinary project opens new perspectives in the fields of bach studies and music performance
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taxonomy and azole resistance in aspergillus section flavi
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the project on taxonomy and azole resistance in aspergillus section flavi aims to investigate the classification and drug resistance patterns of fungal species within this specific section aspergillus section flavi comprises various species known to produce carcinogenic aflatoxins posing significant risks to human and animal healththe project involves taxonomic studies to accurately identify and classify different species within aspergillus section flavi this classification is essential for understanding the diversity and distribution of these fungi as well as their specific traits and potential virulence factors another crucial aspect of the project is the investigation of azole resistance in aspergillus section flavi azoles are commonly used antifungal drugs for treating aspergillus infections however reports of azole resistance in certain aspergillus species have raised concerns understanding the mechanisms behind azole resistance is crucial for developing effective treatment strategies and identifying potential targets for drug developmentthe project involves molecular analysis techniques to detect and characterize genetic mutations or other mechanisms associated with azole resistance in aspergillus section flavi additionally it may involve assessing the clinical impact of azole resistance on patient outcomes and exploring potential risk factors for the development and spread of resistant strainsby combining taxonomic studies with investigations into azole resistance the project aims to enhance our understanding of the diversity distribution and drug resistance profiles of aspergillus species within section flavi this knowledge can ultimately contribute to improved diagnostic methods treatment approaches and public health strategies to mitigate the impact of these fungal infections
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induction of neuromuscular plasticity for natural motor rehabilitation
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neurorehabilitation technologies aim to promote functional neural plasticity in patients suffering from neuromuscular disabilities noninvasive systems for the magnetic or electrical stimulation of the neural pathways are particularly promising for interfacing directly with the nervous system of the patients and restoring coordinated movements despise these potentials current neurorehabilitation systems have still significant limitations since they usually employ stimulation protocols based on specific assumptions on cortical and spinal connectivity an efficient way to overcome this problem will be to estimate neural adaptations during the rehabilitation procedure and optimize its parameters directly the project inception aims to develop innovative methods to estimate patterns of neural connectivity from the decomposition of highdensity surface emg signals and induce reorganization of the connectivity of motoneuron populations innervating the main arm and shoulder muscles using magnetic and electrical stimulation of cortical and sensory pathways the revolutionary concept of the project will be to implant a signature of motoneuron correlation to promote changes in neural connectivity and therefore functional recovery of movements in chronic stroke individuals and breast cancer survivors the approach will provide the possibility to better understand the mechanisms of neuroplasticity in the central nervous system and define efficient stimulation protocols to reestablish natural connectivity in the motoneuron pools of patient individuals by combining multidisciplinary contributions from the fields of neurorehabilitation computational neuroscience biomedical signal processing and neurophysiology the project inception aims to produce substantial progress toward a better understanding of the adaptation mechanisms involved in the connectivity of spinal motor neurons and its use in the next generation of neurorehabilitation systems
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the early exploitation of cetacean in western europe during the late upper palaeolithic
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the whalebone project builds upon new advances in the study of past human adaptations to coastal environments focusing on a key case study early interactions between late upper palaeolithic foragers and cetaceans at the end of the last glaciation in western europe over the last decade a growing body of evidence suggests that the exploitation of whales could have been one of the significant factors underlying the development of early coastal economies during the magdalenian culture between 18000 to 15000 years ago the recent identification of 54 whale bone artefacts in the cantabrian region northern spain during the previous postdoctoral research of the pr to which can be added the 109 previously known pyrenean examples revealed the existence of regular and structured communication networks for the longdistance circulation of these marine resources however these studies focused only on the bay of biscay and it is still unclear whether this phenomenon was a strictly local adaptation or was part of a wider shared coastal economy connecting different parts of europe to test this hypothesis whalebone proposes to identify cetacean bone objects outside the pyreneocantabrian region focusing on the spanish coasts as many magdalenian sites are close to the paleoshorelines that yielded rich osseous industries the mediterranean coast is a particularly crucial area of investigation direct dolphin bones and indirect whale barnacles evidence for the exploitation of cetaceans in its southern part confirms the early interest and management of marine mammals a multiproxy approach beyond traditional zooarchaeology including the first use of an innovative ancient proteomic technology zooms together with a minimally invasive dating program of cetacean bone objects will be undertaken by whalebone in order to address longstanding questions about longterm forager mobility patterns regional interactions and coastal adaptations on a european scale
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should we prohibit luxury emissions of greenhouse gases on top of price constraints
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many share the intuition that the luxury emissions of the global top 1 are morally wrong given the current state of the climate crisis yet the subsistenceluxury distinction has been used so far to justify a right to subsistence emissions rather than a ban on luxury and extravagant emissions prohiblux aims to develop a carbonlimits theory of emissionpermits distribution ie an ethical theory that clearly identifies luxury emissions indipendently of subsistence emissions and justifies their proibition prohiblux research is developed in three stagesfirst the candidate will analyse three possible ethical arguments that can support the carbonlimits claim the axiological argument the imageexternality argument and the moralcorruption argument each argument will be tested against two main objections the offsetting objection and the coercion objection second the candidate will provide identification criteria for carbon limits based on the ethical arguments that pass the objections test and he will address any mismatch by devising an integrated grid of identification criteria third the candidate will lead an ethicsandpolicy analysis of different implementation policies of carbon limits taking also into account the risk of luxury carbon leakage a ban a luxury carbon tax and a notrade individual cap through the training program the candidate will qualify as a researcher at the intersection of ethics and climate policies and acquire new skills related to income and funding generation project management student supervision and scientific communication prohiblux will contribute to the philosophical debate on climate change proposing a new critique of carbon inequality as an alternative to egalitarian utilitarian and subsistencebased arguments prohiblux will contribute to a fair and inclusive transition by developing policyready guidelines for the just implementation of carbon limits
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selflearning aibased transport optimization software as a service for the most complex logistics scenarios in realtime enabling doubledigit cost co2 and tyre wear savings
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smartlanes aibased dispatch software logisticsbrain is a selflearning cloudbased software for automated transport optimization smartlanes core technology the scenariobased optimization ai algorithms in combination with kpi and process analysis optimizes costs by 40 planning time by 90 resources co2 emissions and fine dust by 21 and service quality logisticsbrain is the enabler of full automation for logistic systems and dispatching processes that so far still are based on manual processes sensitivity analyses offer global transport optima by computing several hundreds of scenarios in parallel in this project partial routes are linked to form a network flow by crowdsourcing this allows for real time optimization of transport simply using one software instead of more than three individual solutions as today transport logistics planning challenges are solved by standardized interfaces even for freight forwarders with complex it environments
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worlds first devicebased treatment for small abdominal aortic aneurysms based on revolutionary new treatment paradigm
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the angiolutions device is a firstofitskind device stopping the lifethreatening progression of small abdominal aortic aneurysm aaa a pathological dilation of the aortaangiolutions awardwinning patentprotected solution leverages a fundamentally new understanding of aaa growth discovered by the founders at stanford university they showed that stiffness gradients between the compliant healthy aorta and the adjacent stiff diseased aneurysm serve as a motor for aaa growthbased on this principle together with key physicians we developed a minimallyinvasive nonactive aortic implant class iii the nitinolbased device is positioned adjacent to the aneurysm sack via simple catheterbased implantation it is specifically designed to focally increase aortic stiffness in the compliant aaa neck region thereby reducing stiffness gradients towards the stiff aaa sack that drive aneurysm growthhereby we achieve a fast lowrisk sizestabilizing treatment of small aaa
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european identity theft observatory system
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eithos will develop a novel identity theft observatory system empowering european citizens law enforcements agencies leas and policy makers to further contribute to the prevention detection and investigation of identity theft related crime it will provide a common gateway for identity theft information and intelligence in europe built on top of a modern technological back end based on two pillars 1 inform educate european citizens through the observatory itself and via innovative awareness campaigns regarding the safety of their personal data and identity 2 identify address the challenges that police authorities face against identity theft and develop a robust software toolset to support them and enhance their investigations the proposed system will provide easy access to information and intelligence about previous and current identity theft related trends such as the methods that fraudsters follow to steal information personal data protection or the ways that victims can be supported through its front end while offering a cuttingedge aibased technological toolkit via its back end additionally the project will analyse the societal impact of identity theft as well as the legal framework under which the utilisation of ai remote technologies and eevidence exchange can be achieved focusing on educating civil society and addressing the obstacles that hinder leas to efficiently fight identity theft eithos differentiates from previous projects and other market solutions which often concentrate on digital identity management and secure transactions
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in silico bioevolutio novel ai paradigm for molecular biology
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the success of phage therapies relies on correctly matching a therapeutic phage to bacterial strain however calibration of therapy recipe may last for years presented solution enable to accelerate this by in silico simulations on ai platform for in vitro it is able to find optimal phage that meets the phenotype imposed by the researcher especially predict given phage effectiveness against a specific bacteria strainindicate mutations that increase phage effectivenessgenerate explanations for predictionscurrently this process is performed by wetlab employees in vitro replacing it with an in silico process will reduce the number 90 out of 100 experiments significantly accelerating the process and improving phage therapy quality at the same time its the basis for modern probiotics for microbiome modulation at the same time it will enable dynamically generate personalized therapies for specific patients it is a novel endeavor in the area of molecular biology
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membrane electrode assembly for the high pressure electrochemical conversion of co2 to c2h4
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the electrochemical conversion of co2 to chemical fuels is a promising technology for recycling co2 and closing the carbon cycle amon the different products of the electrochemical reduction of co2 multicarbon c2 product are more desirable because of their high energy density and high market price among them ethylene is widely used for the production of raw materials and has a market price around 1000tons which suggests relatively low threshold towards profitability the development of such a technology to convert co2 to c2h4 is however limited by the lack of selectivity and efficient catalysts to drive the reaction while co2 mass transportation to the active sites limits the conversion rate during the course of our ercstg 2d4co2 we have developed cubased electrocatalysts modified with aromatic functions which demonstrated strongly improved selectivity for ethylene at industry relevant current density of 300 ma cm2 the aim of the hipceo2 project is to apply the novel cubased catalyst develop in our group in a highpressure membrane electrode assembly electrolyzer our specific goals are to realize a prototype with electrode size of 100 cm2 and verified stability of 1000 hours that will be used as a demonstrator to reach out potentials endusers and future partners
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celtic language and identity in northern italy and the alpine region
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the research project cliniar celtic language and identity in northern italy and the alpine region investigates the linguistic and sociolinguistic landscape of celtic northern italy and the alpine region in the iron age the project will be conducted at maynooth university mu ireland under the supervision of the leading authority in celtic linguistics professor david stifter with secondment to universit bordeaux montaigne ubm france under the supervision of dr coline ruiz darasse to receive training in gaulish epigraphy and historical sociolinguistics short visits to repositories in italy will be made for data collection through close linguistic analysis of the cisalpine celtic corpus of inscriptions and the subsequent integration of the data into their archaeological and historical context the project will result in a better understanding of the earliest attested celtic languages in their historical and social dimensions and offer new methodologies to scholars and professionals working in celtic studies fragmentary languages ancient history and digital humanities
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faithbased refugee relief in europe connecting the empirical and the ethical
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fabric develops a new ethics of migration by understanding and utilizing the moral insights and the moral ideas that faithbased refugee relief organizations develop and deploy in practice for the crossdisciplinary debate about the ethics of forced migration in europe globally forced migration is one of the most pressing and one of the most pervasive challenges europe has been pushed to a social and political breaking point over migration the fallout is a death toll that makes the border around the continent the deadliest border in the world faithbased organizations fbos have been at the forefront of this challenge preventing the collapse of the infrastructures of care combatting racist discourse and religious discrimination yet there is very little knowledge about the refugee relief of these fbos so their significance for the ethics of migration has been neither analyzed nor assessed fabric addresses this lack by conducting a comprehensive and comparative empirical exploration of fbos at an unprecedented scale covering activities by fbos from all three abrahamic faiths in mono and multireligious settings across the continent countering the lack of interaction between empirical and evaluative approaches so characteristic of the study of forced migration fabric presents a pragmatist understanding of ethics to enquire into the conditions constraints and consequences of practicing justice it offers a concrete account of faithbased refugee relief in order to formulate a new concept of mobility justice that considers crossconnections between social racial and climate justice on regional national and global scales thus fabric formulates a new ethics of migration from the bottom up putting the debate about the ethics of migration on an empirically more perceptive and ethically more productive footing that advances knowledge production on forced migration across the academy
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the epistemology of dark matter and modified gravity
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andromeda is an unprecedented study regarding the philosophy and epistemology of dark matter and modified gravity the project will synthesize existing knowledge from cosmology and philosophy of science in order to realize an innovative and original study of the epistemological foundations of the debate between theories of dark matter and theories of modified gravity as competing explanations of specific cosmological observations the main objectives of andromeda are a to develop a philosophically informed historical narrative of the parallel development of dark matter theory and modified gravity as an alternative b to identify the most appropriate epistemic values by which dark matter and modified gravity theories should be assessed and compared to each other and c to examine the extent to which certain models of dark matter and modified gravity theory should be evaluated as mutually exclusive and competing explanations of certain phenomena the clear elucidation of these issues will create new avenues for a constructive dialogue between the dark matter and modified gravity communities in physics and will advance the public understanding of theory choice in astrophysics demonstrating how philosophy can i make useful and substantial contributions to an important ongoing scientific problem and ii facilitate the communication of scientific challenges to the public
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structural and biophysical characterisation of insulin receptor and glutamate receptors ampar and nmdar in complex with sorcs coreceptors 1 and 2
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type ii diabetes t2d alzheimers disease ad and parkinsons disease pd are common agerelated diseases which have reached endemic levels and become a burden for the global health lifestyle and environment are risk factors but cannot explain all cases genes also predispose for these diseases common for t2d ad and pd is abnormal cell function associated with dysfunction of insulin receptor ampa receptor or nmda receptor the vacuolar protein sorting 10 protein vps10p family contain five neural type 1 transmembrane sorting receptors sortilin sorla sorcs1 sorcs2 and sorcs3 that play a central role in control of neuronal viability and function by sorting crucial proteins sorcs1 and sorcs2 interact with and sort ir ampar and nmdar and genetic deficiencies for sorcs1 and 2 are associated with accelerated onset of pathology thus implicating these receptors as critical regulators for normal cell function however the molecular mechanisms of sorcs1 and sorcs2 mediated sorting of target receptors are not known and with this proposal i want to determine structures and investigate interactions of sorcs1ir sorcs1ampar and sorcs2nmdar complexes determining the structures of transmembrane sorcs1ir sorcs1ampar and sorcs2nmdar complexes by cryogenic electron microscopy cryoem we will reveal molecular details about the interaction such as the role of interacting elements at cytoplasmic tails transmembrane helices and exodomains and how they define specificity sorcs1 vs sorcs2 function and regulation the proposed project can define new positions and in translational research that aims for drug discovery for t2d ad and pd
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dynamic resource scheduling in massive mimo based noma with rf imperfections and energy harvesting for 6g networks
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yahya6g aims to propose new signal processing solutions doped with machinelearning we will focus on the detectionand compensation of rf imperfections in mmimo massive multiple input multiple output based noma nonorthogonal multipleaccess pair in other hand yahya6g target is to minimize the longterm power consumption based on the stochastic optimization theory for mmimonoma iot networks with eh energy harvesting in presence of rf imperfections thus the objectives of the yahya6g project are1 identify major rf imperfections that may occur in a multiaccess multiantenna broadband system2 propose new solutions to optimize the energy efficiency at the rf transmitters this solution will focus on the power amplifier that represents 60 at 70 of the energy consumed in an rf transmitter3 analyze the impact of these rf imperfections on mobile radio systems exploiting noma technologies4 propose a deep learning online learning process to detect the noma channel characteristics and compensate the effect of hpa nonlinearity a joint detection of the noma interference and hpa high power amplifier nonlinearity will be studiedin mmimonoma system5 resolve a non convex based problem coping with the expected 6g requirements with a particular focus on optimal resource scheduling and computation capacity allocation and reducing energy consumption of wireless devices through a set of new algorithms 6 realize a demonstrator based on the sdr software defined radio usrp cards on which some algorithms developed inthe project will be implemented
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boosting excellence in environmental epigenetics
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the epiboost project joins a widening partner and two internationallyleading partners that will steer a solid capacitation strategy towards tackling the challenges to the recently proposed uptake of epigenomics by environmental assessment frameworks capacitation activities cover for 5 specific objectives the 1st is to optimize research protocols enhancing the practical skills and research profile of the widening partner for the development of excellent science in the field of environmental epigenetics this constitutes the nurturing stage where we will be twinning exchanges and training sessions under an overall philosophy of learning and advancingbydoing allowed by a preparatory research project which will build knowledge on the suitability of dna methylation signatures as informative biomarkers of environmental contamination and effects the 2nd objective is focused on the seeding of the talent that will sustain the european critical mass at the best worldclass standards in the field through the organization of several training events advanced courses summer schools and short courses in scientific meetings targeting young eu researchers the 3rd and 4th objectives regard the absolute need of a capacitated science management and administrative support to effectively grow worldclass research in the field these will be tackled through an immersive training programme focusing key core facilities ethics animal housing sequencing managers exchange for onsite training professional training and realtime funding application preparation the fifth addresses network growing and will be achieved through a systematic strategy for involving international flagship experts in capacitation activities and stakeholders in the project which will strengthen the consortium for new research and innovation ventures
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high throughtput electrophysiological measurements coupled with transcriptomics to reveal cellular dysfunction in type 2 diabetes
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in this project i will develop methods to simultaneously measure transcriptomes with singlecell resolution and perform highthroughput functional measurements of individual pancreatic islet cells i will focus on and cells which regulate glucose levels by secreting the two main glucoregulatory hormones insulin and glucagon and whose dysfunction is associated with diabetes the islet is a highly heterogenous miniorgan making it an ideal tissue to study the relationship between molecular and functional heterogeneity it has been recently developed the use of patchclamp electrophysiology and singlecell rna sequencing patchseq using wholecell electrophysiology in this work i will combine highdensity microelectrode array technology hdmea and transcriptomic methods to identify changes that lead to dysfunctional cellular states in type 2 diabetes to do so i will build a cell cherrypicking system to perform singlecell rna sequencing after electrophysiological measurements in the same islet cell then i will use this system to investigate subpopulations of and cells that have been previously identified in human islets from donors with type 2 diabetes using transcriptomic methods but whose implications in cell and tissue function are yet unclear
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citiobs enhancing citizen observatories for healthy sustainable resilient and inclusive cities
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citiobs will consolidate and apply tools and practicebased knowledge for cocreating data knowledge and local action via citizen observatories cos these tools will enhance existing and new citizen observatories to engage citizens and marginalised communities add value to environmental observations in the urban context increase and validate citizen observations of the urban environment as part of the existing insitu earth observation systems cocreate inclusive local actions for sustainability and ensure that co data contributes to research and policy development towards the objectives of the european green deal to ensure broad use the citiobs tools and approaches will be developed in cocreation with cos in 5 frontrunner cities finetuned with 30 implementer cities and showcased to 50 fellow citiesthe pressure on cities to speed up the process of emissions reduction from pollutants and climate gases is overwhelming the required measures are likely to be found not only in technological development but also in the required social transformations theseis transformations includes increasing citizen involvement and engagement with science and policy increasing awareness of the underlying issues and promoting societal actions to protect the urban environment technological innovations need to be considered within the context of multilevel vertical and horizontal governance structures where citizen participation is recognized and included citiobs will support citizen observatories in distinct cities to createenhanceor scale up inclusive and diverse citizen observatories fostering in particular an active role of citizens in the observation of the urban environment using lowcost sensor technologies and wearables with a particular focus on air quality and related environmental measures citiobs will formalise valorise and legitimise the role of citizen observations
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reprogramming endothelial cells in immunecold tumors
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lung cancer is the leading cause of cancerrelated deaths worldwide currently immunotherapy it is the standard of care for the treatment of some subtypes with only nominal success it works best in inflamed hot tumors and is often ineffective in immune celldesert cold tumors in krasmutated lung adenocarcinoma luad the most frequent type of lung cancer the presence of a mutation in the stk11lkb1 gene is linked to a cold tumor while the cooccurrence of a tp53 mutation corresponds to a hot tumor amongst different cell types in the tumor environment impacting immune cell composition endothelial cells ecs present an important and often overlooked modulator of immune profiles previous research has identified immunoregulatory genes expressed by ecs and proposed immunomodulatory roles of ecs i hypothesize that specific mutations cause the expression of immunosuppressive genes by ecs which might explain the association of gene mutations affecting the immune environment thus modulating ecs to reprogram them into immunostimulatory phenotypes in the immune cold tumors could present a promising strategy to improve it responses to identify the immunosuppressive gene signature in ecs in immune cold vs hot tumors i will utilize transgenic mouse models of luad krasg12d lkb1floxflox kl and krasg12d tp53floxflox kp mice first using scrnaseq i will establish an ec signature linked to the immune cold tumors and subsequently to identify ecspecific candidate immunosuppressive targets after that i will use stateoftheart technologies that enable efficient gene targeting to validate the discovered targets in kl mice i perform multidisciplinary approaches to delineate the molecular mode of action of the target exhibiting a substantial therapeutic effect in mice and overcoming the resistance to current anticancer it finally i will employ a humanized orthotopic lung pdx mouse model to further validate and test therapeutic opportunities
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biocatalytic fluorescence switchon polymerizations for signal amplification in ultrasensitive diagnostics and biosensing of malaria
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malaria is one of the most catastrophic infectious diseases causing nearly 250 million deaths in 2021 according to who although malaria is curable delayed diagnosis is the leading cause of death in malaria patients the major obstacle in malaria diagnosis is clinical assessment by conventional methods which requires welltrained clinicians and expensive equipment moreover pointofcare diagnostic tests are not sensitive enough to accurately detect low levels of parasitemia thus there is an urgent need for a rapid accurate and highly sensitive malaria diagnostic method based on the detection of parasite biomarkers in the bloodstream and amplification of weak parasite signals by novel methodsin recent years atom transfer radical polymerization atrp a controlled radical polymerization has been studied as an attractive method for signal amplification in biosensing because the chain reaction accumulates monomers in the form of polymers at the site of polymerization in addition clinically relevant metalloproteins have been detected using this polymerbased signal amplification techniqueherein the aim of this work is to develop biocatalytic fluorescent switchon polymerizations with a triple signal amplification strategy for ultrasensitive diagnostics and biosensing of malaria the polymerizations will be used in assays for malaria diagnosis based on hemozoin metabolic byproduct of all plasmodium species and in immunoassays that involve antibodyperoxidase conjugates lateral flow immunoassay enzymelinked immunosorbent assay elisa and immunofluorescence staining for low abundance malaria antigens the diagnostic platform will be a collective combination and use of multiple independent technologies in a unique design to detect realistic and feasible malaria biomarkers found in peripheral blood
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measuring and modelling tectonic co2 emissions through time
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geological processes governed paleoatmospheric co2 variations and exerted major control on past climate change beyond the millionyear time scale vast deep carbon reservoirs are known to be activated at continental rifts where the faulted lithosphere provides co2 pathways and where recent surveys detected massive co2 emissions however progress in quantifying natural co2 degassing and its impact on past climate is impeded for 3 reasons 1 current co2 flux measurement techniques require labourintensive field surveys that can cover only small areas 2 a consistent framework uniting geodynamic processes and co2 transport to the surface is missing 3 past co2 flux from rifts is difficult to quantify because compilations do not account for geodynamic characteristicsemerge will enter uncharted territory by linking 3 innovative approaches the project will 1 advance airborne co2 flux measurements via drones focusing on rifts in kenya ethiopia czech republic and iceland we will measure for the first time tectonic co2 flux distributions of entire regions allowing unprecedented insight into subsurface co2 pathways 2 characterise geodynamic controls on lithospheric co2 transport via novel numerical modelling techniques and 3 integrate data of all known rifts since 540 million years ago to understand the role of tectonic degassing in shaping earths climate through timezooming in on the geosphereatmosphere interface this project integrates interdisciplinary ideas and methods from geodynamics micrometeorology petrology and paleoclimatology emerge may generate broad impact on scientific and societal level dronebased co2 flux measurements will be a game changer in understanding tectonic co2 release at rifts and other plate boundaries worldwide the methodological and scientific advances may be essential for establishing a solid baseline of tectonic co2 emissions to accurately quantify controls on past and future climate change
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promoting ocean and water literacy in school communities
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probleu will expand and support the network of european blue schools attract a wide diversity of new members improve ocean and water literacy across school communities and contribute to the objectives of the mission in particular 1 to protect marine and freshwater ecosystems and biodiversity and 2 to prevent and eliminate pollution probleu recognises that a significant change in environmental education is needed to foster broad societal responsibility towards oceans and waters and to encourage related behavioural change probleu will develop and offer a pool of innovative practical resources based on methodologies of open schooling besides several actions to promote encourage participation in and increase the diversity of the network two resources currently lacking from the majority of school curricula are explored in probleu 1 those related to what is collectively known as citizen science with work undertaken by educators together with communities to advance science foster a broad scientific mentality or encourage democratic engagement which allows society to deal rationally with complex modern problems and 2 the interaction with scientists in the field collecting and analysing data through citizen science ensures that student activities contribute directly to fostering their ocean and water literacy students engaging with the work of scientists eg through direct interaction or following the work on ocean research cruises have shown improvements in learning in the past but this opportunity tends to be limited to relatively few or privileged schools these resources will be complemented by stimulating the connection between people and the places where they live by fostering relationships between the school communities and their local waters probleu will assist schools in developing project activities related to the mission
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croatiacyprus excellence hub on ecoinnovative technologies for healthy and productive seas
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the main goal of the seatechub project is to strengthen croatian and cyprus placebased innovation ecosystems and improve access to excellence for ri actors by crossborder collaboration on a common strategy and alongside value adding chains within the area of ecoinnovative technologies for healthy and productive seas focusing on sectors 1 aquaculture and fisheries 2 smart ports 3 maritime security and protection 4 research and education and 5 maritime technologies which are aligned with croatian and cypriot smart specialization strategies and have been identified as emerging and established sectors in the eu blue economy report 2021 the objectives of the seatechub project are 1 to facilitate longterm cross border and intersectoral collaboration to advance ecoinnovative technologies for healthy and productive seas 2 to perform joint research work to close knowledge gaps consolidate and reinforce quadruplehelix linkages and validate strategy and action and investment plans aips 3 to implement a set of mutual learning and skills development measures and 4 to raise visibility of croatiancyprus innovation ecosystems by implementing strategic measures in the form of organizing networking knowledge and experience transfer eventsthese objectives will be reached through a set of measures that include a development of the strategy and aips and their digitalization through an innovative platform utilizing blockchainbased tokenization b ri projects selected considering crossborder and crosssectoral needs within c conceptual design and preplanning for pilots and demonstrators and d a set of accompanying measures and outreach activitiesthe seatechub consortium covers the quadruple helix of croatian and cyprus ecosystems 2 research organizations 4 public authorities 5 business actors and 3 ngos strong willingness to actively participate has also been expressed by 49 institutions who have provided letter of support
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predicting the fate of plastic on beaches by their 3ddistribution and weathering processes
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recent global plastic pollution models predict that two thirds of the plastic mass released from land into the ocean since 1950s is likely to have stranded around the worlds shoreline yet our knowledge about the degradation burial and transportation fate of beached marine plastic debris mpd remains limited and little is known about the exact capacity of beaches to store mpd to fill in current knowledge gaps in global monitoring of mpd we propose a novel approach based on repeated fieldsurveys of surface and buried mpd and studying the physicochemical transformations induced by mpd aging on hawaiian beaches which are known hotspots for mpd due to their proximity to the north pacific garbage patch data collected from repeated surveys of surface and buried mpd on beaches will generate 3d maps of mpd and assessment of temporal mpd fluctuation and accumulation zones of mpd with respect to the type size and density of mpd present on the surface and in the sand column following the aging of plastic debris when stored on beaches will reveal dominating mpd transformations and rates including fragmentation rates which will provide key information eg changes in density buoyancy and fragmentation to model fate transportation and transformation of mpd in coastal environments we envision that outcomes from storage can timely provide scientific evidence supporting decision making within the present and future legislative measures against plastic pollution prompted by the eu and global agreements the interdisciplinary transfer of knowledge needed for storage will be facilitated through stays at the center for marine debris research cmdr at hawaii pacific university hpu in the us laboratoire structures matriaux avancs et sollicitations hyperbares smash at ifremer in france and a secondment at the research team at the ocean cleanup office in the netherlands and brings together key actors in mpd analysis and sampling plastic pollution modelling and polymer science
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fintech investor network and ecosystem
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fine aims to create more inclusive and connected networks between fintech ecosystems on a local and international level by promoting collaboration between investors through coinvestment for fintech startups thus creating a richer investment climate that will support innovation and company scaleup across borders fine will conduct a mapping of key ecosystem players in target countries ranging from developed to lessdeveloped fintech environments to create a knowledgebase containing information relevant to investing in that country including key players regulatory frameworks and uptodate news articles covering local investment trends and opportunities fine will promote an inclusive investment ecosystem by creating educational material on an online investoracademy that empowers new investors young investors and women and minority investors to learn investment fundamentals and casespecific knowledge about investing in fintech fine will actively manage communitybuilding activities between investors and local networks across countries by developing a matchmaking tool and animating introductions events workshops webinars and other activities fine will also set up a fintech ambassador network to support international investment and provide expertise to local and foreign actors policy recommendations will be formulated concerning strategies to attract investors in emerging ecosystems and how to attract new investors young investors women investors and other underrepresented groups moreover recommendations on incorporating esg principles in the investment screening process will be created hence fine aims to bring new investment and capital to lessconnected ecosystems enabling latestage growth of local startups by facilitating and animating increased investor deals with local actors and improving investor knowledge on regulatory frameworks and opportunities while supporting more inclusive and genderequal measures in investment
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ai engineering suite to support agile efficient software engineering
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ai4softeng represents an excellent chemistry of 13 partners including experts and practitioners in modeldrive software engineering and ai engineering particularly llms from across europe and usa with four usecases from software development healthcare cyberphysical system involving multiarchitectural and resourceconstrained systems and next generation battery management in evs the ai4sofeng mission is to significantly contribute to the transformation of agile software development into a sector turbocharged for designbycontact high efficiency reliability and securityprivacy compliant delivery this is to exploit advanced aipowered software development support to deliver highquality reliable fast timetomarket solutions that are socially responsible scalable sustainable and lend themselves to audible ethical and regulatory complianceai4softeng aims deliver aipowered support to software developers to help reduce worker stress past the painpoints in agile sw development pipelines and higher productivity thus enhanced job satisfaction and creativity accordingly the project will develop deliver and validate in 4 usecases a platform comprising a set of tools including aisysdev and test automation tool to support the software lifecycle endtoend for both functional and nonfunctional deliverables by supporting a host of tasks such as code generation crosscompilation advanced debugging and dynamic slicing adaptation securityprivacy by design reliability energy efficiency and adaptation as well as project management process quality and maintenance support through datadriven insights for informed design decisionmaking and strategic software development planning additionally with a commitment to advance usercentred design it will provide structured design in advanced prompt engineering to support software developers team to best exploit to capabilities of the platform
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dangerous liaisons classical antiquity and lgbtq movements in greece the uk and the us
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contemporary lesbian gay bisexual trans and queer lgbtq movements actively engage with the past through archival selection and historiographical accounts they construct interpret and preserve their collective identities the proposed project homoclassicisms focuses specifically on the cases of lgbtq movements in greece the uk and the us its research goal is to address through the use of innovative qualitative methodologies from a southern epistemological perspective the position of classical antiquity in lgbtq historiographies the project aims to investigate whether the movements might become complicit with racialised narratives of identity formation in their articulation of particular pasts embracing a bottomup approach the project adopts an intersectional and interdisciplinary perspective to map understand and critically analyse longstanding omissions in lgbtq historiographies indeed this is a timely and urgent undertaking in light of transnational migration and demographic dynamics currently challenging western societies investigating who is included and who is excluded within lgbtq historiographies becomes a critical project the project thus firmly aligns with the fourth key strategic orientation of horizon europe he creating a more resilient inclusive and democratic european society the projects publication plan includes four peerreviewed articles its extensive impact involves engaged modes of dissemination with international lgbtq communities archivists policymakers and the general public following hes paradigm change from an activitydriven to an impactdriven approach the fellow will acquire the necessary skills and research mentoring to analyse intersectional inequalities in relation to politicised uses of the past in a transnational context and to inform enrich and challenge theoretical debates originating from global north over lgbtq historiography providing policyrelevant results
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the first ivdrapproved commercial software solutions for aipowered rnabased companion and precision cancer diagnostics of acute myeloid leukaemia and bladder cancer
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qlucore is developing visualisationbased analytical solutions with an established position in the nextgeneration sequencing ngs market as pioneers in rnadata analysis we aim to revolutionise the field of companion and clinical diagnostics by developing software platforms integrating aipowered machinelearning classification models for gene expression signatures and gene fusion analysisby providing highly accurate and specific diagnoses our platform represents the future of precision oncology putting europe at the forefront of aipowered cancer classification a softwarebased setup speeds up the introduction of new clinical guidelines and companion diagnostic solutions with the ultimate purpose of increasing survival rates and overall health we aim to cover all cancer types relevant for gene expressionbased diagnostics and then scale up into noncancer indications eg cardiovascular and neurological diseases immunological disorders and other data types eg proteomics and singlecell rnaseq further disrupting the precision diagnostics industry currently we are preparing the solution with a classification model for bcell progenitor acute lymphoblastic leukaemia bcpall for the first ivdr certification proof of concept building on those achievements and leveraging regulatory and data management experience and progress in the proposed project we will focus on acute myeloid leukaemia aml and bladder cancer bc for aml and bc we will develop and cecertify classification models and companion diagnostics cdxspecific classification models the successful completion of this project will significantly improve europes position in genomics and aibased precision diagnostics and as such prompt similar initiatives across europe this will allow the eu to compete effectively with market leaders in particular the us and offer significant benefits to patients diagnosed with cancer and society as a whole
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mechanisms of human cotranslational quality control and its role in neural tissue
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ribosomeassociated quality control rqc is crucial for degrading truncated nascent proteins produced on aberrant mrnas this is done by elongation of the nascent chain on the large ribosomal subunit in the absence of mrna and the small ribosomal subunit cat tailing and by marking the nascent chain for degradation mutations in rqc components cause neurodegeneration both in animal models and human patients moreover rqc insufficiency and subsequent protein aggregation critically contribute to proteostasis impairment and systemic decline during ageing strikingly we lack mechanistic understanding of this crucial process in humansthis project stems from my postdoctoral research in which i have solved the structure of the yeast rqc complex and discovered a novel rqc factor the eif5a this conserved protein is critical in yeast rqc and was recently implicated in brain development and huntingtons disease moreover i have developed a human cellfree translation extract which enables structural studies of cotranslational processes in the human system in the proposed research we will provide mechanistic understanding of cat tailing and nascent chain degradation in human rqc using cryoem we will define working principles of rqc components and the mechanisms by which their diseasecausing mutations specifically affect neurons in vivo using the c elegans as a model organismour approach utilizes a multidisciplinary approach to provide detailed mechanistic understanding of the critical rqc system in combination with an in vivo study to reveal processes leading to rqcdriven pathological changes in neural tissue since the rqc pathway is conserved in all kingdoms of life and serves a pivotal role in protein homeostasis with critical implications for neurodegenerative disorders and ageing our findings will have important implications for human health and the potential to reveal novel drug targets
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the spatial organization of gene regulation in embryonic development
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master transcription factors tfs cooperate with chromatin in regulating genomic activity in animal development and stress response local clustering of tfs into dense submicrometer size condensates is emerging as a key feature of transcriptional regulation this includes intranuclear condensates formed by pioneer tfs during development transient clusters of rna polymerase ii complex and nuclear stress bodies formed during a heat shock despite the ubiquity of these assemblies we know little about the biophysical mechanism of their formation or physiological function the last years have seen the development of new frameworks to study such transient assemblies including various types of phase transitions and tools to probe and modulate them however this work has been limited mainly to cell culture and in vitro experiments that failed to incorporate the vital role of chromatin in organizing gene regulation i propose a crossdisciplinary strategy consisting of a novel in vitro assays and functional studies in a nematode caenorhabditis elegans to study the spatial organization of transcription in embryonic development and stress response the specific aims are1 understand the physiological relevance of transcriptional condensates in animal development and stress response2 determine the molecular composition and regulators of transcriptional condensates 3 dissect the mechanism of transcriptional condensate formation using a novel chromatin carpet assay we will use stateoftheart microscopybased tools to investigate the formation and function of nuclear condensates in developing animal embryos and develop innovative assays to probe the condensation of tfs on the surface of purified native chromatin the obtained results will provide an unprecedented insight into the composition assembly mechanism and physiological relevance of biomolecular condensates formed by the transcriptional apparatus during differentiation and stress response
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development of functional fish feed based on bioactive compounds of marine and herbal origin
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feedactiv focuses on the development of innovative aquaculture feed based on natural bioactive compounds that boost the immune system of farmed fish various species of marine microalgae as well as seaweed and land based herbal plants are going to be used as enrichment of the fish feed and hopefully as partial fishmeal substitution with low cost ingredients the use of natural compounds polyunsaturated fatty acids 3 6 and 7 phenols carotenoids and protein from marine and land based flora aims to improve the breeding and quality of farmed species while drastically reducing the annual cost of the aquaculture companies by focusing on the processes that boost the immune system of the fish the production of these functional products will cover the consumers demands for the consumption of foods with increased functionality and absence of any chemical additives giving them the following comparative advantage over the competition the overarching objective of this project is to form an international and intersectoral network of organizations working on a joint research programme in the fields of aquaculture and feed formulation therefore feedactiv will bring together experts from industry and academia that specialize in interdisciplinaryintersectorial yet highly complementally research areas of aquaculture animal feed production feedfood safety process analysis and design of food products it is a joint research and innovation project that will develop a strong partnership involving 8 partners from 3 european countries romania greece and italy and with different technical backgrounds from the academic and nonacademic sectors smes the execution of the project and the knowledge sharing will be based on secondments exchanges of research and innovation staff with an inbuilt return mechanism strengthening collaborative research among the different countries and sectors
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magnificoprecommercialization of multifunctional targeted mricontrast enhancing agents for brain research
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magnetic resonance imaging mri is a nondamaging and noninvasive imaging modality with the abilities to effortlessly image the entire brain at any depth however mri provides images with low contrast and very poor resolution and these are but an indirect description of features in the tissue eg cells because mri images water protons these aspects limit the use of mri in preclinical research settings eg biomedical research to study brain diseases resultantly pharmaceutical and biotechnology companies are constantly in search of novel methods that endow mri with capabilities to distinguish defined biological targets for the study of brain diseases in animal models currently there are no suitable solutions we specifically address these shortcomings and extend the capabilities of mri by developing an allinone solution the solution consists of the synthesis of novel targeted fluorescent contrast agents suitable for light microscopy computed tomography and mri and the parallel engineering of cells when combined cells in the brains of animals can be detected by mri in vivo lastly we provide a unique ex vivo protocol for validating the targets imaged by mri in vivo
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building vascular networks and bloodbrainbarriers through a biomimetic manufacturing technology for the fabrication of human tissues and organs
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tenths of millions of people with organ failures or suffering from degenerative diseases are waiting for a novel cellular therapy or for a transplant of a donor compatible organ and the immense majority of these patients will die before receiving the tissue or organ they need despite the significant advances in tissue engineering not a single artificial tissue has been used to replace a part of an organ with the exception of simple or avascular tissues like skin or cartilage thor proposes the development of a revolutionary tissue engineering technology capable to produce any type of human tissue for organ repair or replacement in case of illness trauma or degenerative diseases patienttailored tissues will be fabricated by pools of bioinspired minirobots in fully automated production plants using the breakthrough incremental technologies of the thor project selfassembling molecules inspired to the extracellular matrix selfassembling solid and hollow polymeric fibers materials functionalization using photoactivable crosslinkers cuttingedge mini robots to wave 3d selfassembling structures with factors and cells with micrometric precision thor tissue arises from highresolution 3d spatial positioning of selfassembling structures angiogenic factors and relevant cell lineages reprogrammed and expanded in a dedicated bioreactor under controlled conditions our longterm vision encompasses 1 the establishment of a tissue engineering industry for personalized organ repair producing any type of well vascularized and fully functioning tissues and 2 the maintenance of such tissues alive for long periods of time for an easy transportation to hospitals and clinics even far from the big cities thor will foster the rise of a new industry and of a new biomedical field while cadaveric donors transplants will not be necessary
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democracy autocracy and international cooperation
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one of the most consistent findings in the study of world politics is the positive relationship between democratic regimes and international cooperation yet events in recent years suggest a more complicated picture several democracies have withered in their support for international organizations while autocracies simultaneously have stepped up their commitments to cooperation this project will use recent developments as a backdrop for launching a new research agenda on the relationship between regime type and international cooperation guided by the overarching question of why how and under what conditions regime type affects international cooperation this project will conduct the most systematic and comprehensive analysis so far of this relationship theoretically it will break new ground by developing a novel framework for identifying how regime type may have varying and conditional effects on international cooperation empirically it will be more comprehensive than any previous research effort examining this relationship over a longer time period and across a broader range of international cooperation based on an extensive new data collection methodologically it will leverage an ambitious multimethod design combining largen statistical analysis experimental analysis and indepth case analysis in a complementary fashion and with a comparative orientation in addition the project will be policy relevant by generating insights on the resilience or not of international cooperation in an age of democratic decline
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strengthening research and innovation excellence in autonomous aerial systems
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built on lessons learned and experience gained upon successful implementation of twinning project aerotwin this proposal is conceived as an effort to stream aerotwin positive effects on a network of higher education institutions heis from croatia and bosnia and herzegovina in order to enlarge capacity for research and innovation and to prepare and establish a long lasting and integrated cooperation between those institutions and their partners in the local ecosystem the essential support to reach this objective and prepare the network to facilitate future synergies with the european universities initiative will come from three internationallyleading heis from spain czech republic and the netherlands additionally increase of innovation capabilities of widening heis will be achieved through close cooperation with fadacatec and technological corporation of andalusia cta leading european research and innovation intensive organizations deeply involved in the most relevant eu initiatives and projects the long lasting and integrated cooperation between institutions will be established in the field of autonomous aerial systems aas applications with emphasis on smart agriculture forestry and logistics the project objectives are i integrated and long term cooperation between heis from croatia and bosnia and herzegovina with partners from spain czech republic and the netherlands ii increased scientific excellence profiles of heis from croatia and bosnia and herzegovina in the field of autonomous aerial systems and shared capacities with partners from spain czech republic and the netherlands and iii improved quality of innovation management technology transfer and citizen involvement of heis from croatia and bosnia and herzegovina particular set of actions is planned for achieving those objectives such as common innovation strategy staff exchange experts visits workshops and tutorials handson trainings and phd students comentoring
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probing the finelyresolved 100 tev gammaray sky for ultraheavy dark matter
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dark100 will shine a light into an underexplored dark matter particle mass range driven by recent theoretical developments both in tools and motivation dark100 will search for dark matter particles between 100 tev and several tens of pev leveraging novel costeffective telescope technology dark100 will deploy an array of telescopes capable of probing dark matter annihilation improving on the sensitivity of currently operating and planned gammaray instruments by an order of magnitude with unprecedented energy and angular resolutiondark100 will build a unique dataset of deep gammaray observations of darkmatterrich astrophysical systems dark matter will potentially be detected or in the event of nondetection limits on its velocityweighted annihilation cross section will be set for a nondetection dark matter will be ruled out for part of the probed mass range and theoretical models constrained for the full probed mass rangethe impact of dark100 will be felt beyond the dark matter community by demonstrating a new gammaray telescope paradigm dark100 will enable a range of possible astrophysical studies with gamma rays above 100 tev including searches for galactic pevatrons and transient events its public data archive will encourage synergy with other gammaray instrumentsdark100 takes advantage of a unique moment in theoretical and technological development that enables its pioneering science goals while the theoretical motivation is fully developed and the technology is welltested the deployment of the dark100 array and collection and interpretation of its observations is an ambitious project that demands the resources of an erc consolidator grant the pis leadership in dark matter searches and gammaray analysis and simulation make her ideally suited to direct this program
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the roots of civility french renaissance literature as a laboratory of modern civility
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renaissance men and women had a passion for virtue and a genius for cruelty they had wonderful manners and barbaric inclinations lovely clothes and terrible diseases can they really teach us something about civility i think they can they were made of contradictions and so are we and both we and they dream of a society where politeness and respect reduce tensions and allow a peaceful and pleasant cohabitation for all the goal of this research project executed at the university of lille under the supervision of marieclaire thomine is to prove that the roots of civility go back to the 16th century and that there was a mature form of civility in the renaissance france a century before what is usually considered to be the beginning of the politesse française i will identify its main models and situate them in relation to the previous medieval ones and those from the century of louis xiv i will argue that renaissance authors used the literature as the principal means of wide diffusion of this new civility and this is precisely what makes this century a turning point in the history of manners in france and a part of the cultural reform initiated by the kings and queens of france to build a more cohesive and peaceful society furthermore i want also to prove that this evolution can be observed using the modern tools of historical pragmatics a branch of pragmatics that had developed strongly over the last twenty years but was not yet used to study the phenomenon of impoliteness in france during the renaissance i will accomplish those goals through a program of close reading of prose texts essentially literary dialogues and collections of short stories of the 15th and 16th centuries informed by the literature of civility and through corpusbased research to detect and define evolution in verbal and nonverbal behaviors in the time of the last kings of the valois dynasty
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the role of structural variation in adaptive radiation
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long distance dispersal and adaptive radiation events have produced some of the most species rich ecosystems in the world while colonizing lineages can adapt to new environments the selective processes by which they do so is unclear given the paucity of genetic diversity in founder populations recent interest in the evolutionary role of transposable elements suggests they may contribute in generating genetic diversity through structural variation doing so faster than the rate of background mutation despite research to date evidence for exact mechanisms of transposable element mediated adaptive evolution is sparse to address this i propose to study a radiating clade of diospyros ebenaceae species on new caledonia a biodiversity hotspot following a long distance dispersal event ca 30 species form an adaptive radiation and have larger genome sizes than congeners that arrived independently on the archipelago previous work has suggested that the divergence within the radiating lineage was driven largely by edaphic specialisation occurring independently multiple times here i plan to investigate whether genes involved in adaptation to soil type are associated with structural variants and whether these variants are mediated by transposable element activity i will use three pairs of sister species each of which is adapted to either fertile volcanic or poor ultramafic soils enabling me to test for repeated patterns of adaptive evolution this action will shed light on the potentially crucial but poorly understood contribution of transposable elements to adaptation speciation and biodiversity moreover this work will provide understanding of the adaptive limits of different lineages in the face of ecological upheavals relevant in the present context of environmental challenges
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formalizing verifying and applying isa security guarantees as universal contracts
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the instruction set architecture isa is the interface that processor hardware offers to software developers current isas do not explicitly specify the security properties guaranteed by that interface so that for example recent severe microarchitectural sidechannel vulnerabilities like spectre did not even violate the specifications this project proposes a fundamentally new approach to specify isa security properties by using what we call universal contracts these are formal contracts in a compositional program logic that automatically hold for arbitrary code such contracts capture isaenforced upper bounds on the effects of arbitrary even attackercontrolled software while this approach is widely different from traditional specifications the approach looks extremely promising universal contracts can be applied to general security primitives mechanically verified against the isas operational semantics and they make it possible to obtain fullsystem security proofs by manually verifying only the trusted code of a sytemin this project we will contribute reusable techniques and tools for applying universal contracts in realistic isas to this end we will 1 design prove and evaluate universal contracts for isas with stateofpractice security primitives 2 develop semiautomation machinery for verifying universal contracts of isas 3 extend universal contracts to deal with semantic complications like concurrency or microarchitectural sidechannels and 4 design implement and evaluate techniques which facilitate the construction of trusted software that relies on universal contracts particularly assemblylevel reasoning support and secure compilers if successful the project has the potential to fundamentally improve the security foundations of all softwarebased systems by 1 clearly dividing the security responsibilities between hardware and software developers and 2 enabling scalable rigorous fullsystem security proofs
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targetting neutrophilmediated neurotoxicity for the treatment of alzheimers disease
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with the neutrad erc poc project we present the first diseasemodifying alzheimers disease ad drugs that abrogate leukocytemediated neurotoxicity and represent a novel class of drugs in the treatment of adad is a neurological disorder characterized by progressive deterioration of cognitive function and leads to death within 39 years after diagnosis ad is highly prevalent in elderly and it is estimated that 35m patients suffer from the disease worldwide as a result ad has tremendous social and economic impact this is aggravated by the lack of diseasemodifying drugs as current therapies only provide shortterm symptomatic benefit hence novel therapeutic approaches are of critical importance to resolve this urgent and growing health crisis our novel antiad drug candidates use a neutrophiltargeted approach and unlock a novel avenue for the millions that suffer from ad growing evidence supports the role of inflammation in the development of neurodegeneration in ad for example our previous research has demonstrated a role for neutrophils in the induction of memory decline and neuropathological hallmarks of ad furthermore our data shows that a highly activated and degranulating neutrophil phenotype induces neurotoxicity in an in vitro ad context preliminary results have also demonstrated that our novel drug candidates rescue neuronal death and have diseasemodifying potential in adlike mouse modelsin neutrad we will explore the technical and commercial potential of our drug candidates as the first diseasemodifying drugs against ad specifically we will optimise and subsequently test the technical feasibility of our two drug candidates in adlike in vitro and in vivo models in parallel we will explore the commercial opportunity of our novel ad drugs and analyse the ip position and strategy as well as the market and existing and emerging competitors finally we will consolidate the project outcomes in an investorready business plan
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a leap towards sae l4 automated driving features
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the introduction of connected cooperative and automated mobility ccam can make a significant improvement to logistic chains the modi project will identify and largely resolve barriers on confined areas and on public roads for sae l4 ccam vehicles on the corridor from rotterdam to oslo and demonstrate the solutions coordination is a central element of development in this project it enables early integration of ccam in current logistic vehicle operations adding more efficiency benefits for logistics companies and thus creating an attractive path to deployment coordination is also needed for smart traffic management in the public domainthe project comprises five different use cases each describing a part of the logistics chain it identifies what is already possible on sae l4 and what is not possible yet for the public roads the project will focus on understanding and overcoming the regulatory barriers and pdi shortcomings on the motorway corridor with road authorities and oems of the project involved in cocreation with all stakeholders the project will search for an optimal combination of physical digital infrastructure and oem equipment easy to implement and low in costs for all partiesin addition to the demonstrations the project provides detailed business models for the logistics sector demonstrating that the use of ccam can lead to greater profits especially when vehicles drive on a coordinated waythe consortium consists of 8 industry partners oems its solutions providers test centers and logistical companies engineering and research providers with 4 rtos 3 universities and associations of logistical companies tier 1 companies its service providers complemented with road authorities and citiesregions along the corridor representing the complete value chain a strong stakeholder group is committed signed los
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facilitating innovations for resilient livestock farming systems
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the overall objective of relivestock is to evaluate and mobilize the adoption of innovative practices applied crossscale animal herd farm sector and region to reduce ghg emissions from livestock farming systems and increase their capacity to dealing with potential climate change impacts to reach our aim relivestock have brought together the excellence scientific expertise in europe and australia and across disciplines including coinnovation animal feeding breeding welfare farm management environmental and socioeconomic assessment and policy analysis to develop novel and scientifically supported integrated approaches specific for different dairy beef and pig systems and geographic regions in the context of climate change strong collaboration with industry stakeholders to identify the innovations and to codesign the validation will ensure relevance and maximise the adoption of best practices national groups of farmers case studies and stakeholder forums together with a european multiactor platform will allow for an engaged codesign of transition pathways whilst learning from innovation networks will allow for the testing and sharing of latest innovative solutions a community of practice will extend the multiactor approach to a broad range of stakeholders
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life cycle center for power cable diagnosis
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the eu goals for the clean energy transition require at least a 55 reduction in greenhouse gas emissions from 1990 levels by 2030 according to the fit for 55 package to achieve these goals electricity grids will be required to operate in an overall context of 50 electricity production from res of any scale by 2030 the huge rise in the share of solar pv and wind in total generation fundamentally reshapes the european power system and significantly increases the need to build new hvac or hvdc cable connections these will have a crucial role to link islands or offshore wind parks to mainland or to connect countries over long distances the cablegnosis project aims to deliver innovative cable technologies that will support the clean energy transition era for the 2050 targets set at european level cablegnosis project will develop innovative insulation and conductor design technologies high performance and environmentally friendly cable insulation materials ageing studies of superconducting cables recyclability technologies for the materials used in power cables as well as prefault condition aging and remote monitoring aibased tools a feasibility assessment framework and detailed analysis for the use of superconducting cables for submarine connections a respective feasibility analysis will be developed for the offshore wind parks in the netherlands and germany the cablegnosis technologies will be validated in five european countries italy uk greece hungary cyprus cablegnosis will deliver a complete deployment plan for supporting the development and operation of efficient reliable and environmentally friendly cable systems to support the energy transition the deployment plan will provide the scalability and replicability framework of using the cablegnosis technologies in future cable development projects with emphasis in the ukmorocco interconnection cyprusisrael interconnection offshore developments in the aegean sea
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environmental gentrification and emerging collectives in uncertain times
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in the global north in the face of the looming threats of manifold environmental crises there is an increasing sense of urgency to enhance cities sustainability yet topdown paradigms of urban regeneration can contribute creating enclaves of environmental privilege thereby excluding lower income and minority groups from their benefits much recent scholarly debate has focused on the multiple effects of evictions and displacements as well as on active practices of resistance but what happens if after years of protests grassroots groups become the main actors in processes of collective reappropriation and management of urban spacestakeback is an anthropological study of emerging forms of collective care at a moment where the interlocking crises of capitalism democracy and the environment have become more apparent than ever before it follows a comparative case study design through the analysis of different urban mobilizations focused on the collective reappropriation andor use of exindustrial areas in north america montreal canada and europe turin italy it is based on indepth ethnographic research which will include the analysis and production of visual materials by exploring evolving practices and understandings of care within activism takeback will contribute to debates on the shifting meanings of urban citizenship in an increasingly vulnerable worldthe project will be based at polytechnic of turin with an outgoing phase at concordia university montreal takeback will allow me to gain new knowledge in the areas of urban geography and visual ethnography to combine this with my previous expertise in political anthropology and ethnographic research and it will act as a pilot for my own erc starting grant ultimately the project will expand theoretical and practical knowledge about grassroots solutions to the challenge of building more equal and sustainable urban environments
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