import os
import tempfile
import requests
import torch
from typing import List
import chromadb
from chromadb.config import Settings
from transformers import AutoTokenizer, AutoModel

# Optional: Set your PubMed API key from environment variables
PUBMED_API_KEY = os.environ.get("PUBMED_API_KEY", "<YOUR_NCBI_API_KEY>")

#############################################
# 1) FETCH PUBMED ABSTRACTS
#############################################
def fetch_pubmed_abstracts(query: str, max_results: int = 5) -> List[str]:
    """
    Fetches PubMed abstracts for the given query using NCBI's E-utilities.
    Returns a list of abstract texts.
    """
    search_url = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi"
    params = {
        "db": "pubmed",
        "term": query,
        "retmax": max_results,
        "api_key": PUBMED_API_KEY,
        "retmode": "json"
    }
    r = requests.get(search_url, params=params)
    r.raise_for_status()
    data = r.json()

    pmid_list = data["esearchresult"].get("idlist", [])
    abstracts = []
    fetch_url = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi"
    for pmid in pmid_list:
        fetch_params = {
            "db": "pubmed",
            "id": pmid,
            "rettype": "abstract",
            "retmode": "text",
            "api_key": PUBMED_API_KEY
        }
        fetch_resp = requests.get(fetch_url, params=fetch_params)
        fetch_resp.raise_for_status()
        abstract_text = fetch_resp.text.strip()
        if abstract_text:
            abstracts.append(abstract_text)
    return abstracts

#############################################
# 2) CHROMA + EMBEDDINGS SETUP
#############################################
class EmbedFunction:
    """
    Wraps a Hugging Face embedding model to produce embeddings for a list of strings.
    """
    def __init__(self, model_name: str):
        self.tokenizer = AutoTokenizer.from_pretrained(model_name)
        self.model = AutoModel.from_pretrained(model_name)
        self.model.eval()
    
    def __call__(self, input: List[str]) -> List[List[float]]:
        if not input:
            return []
        tokenized = self.tokenizer(
            input,
            return_tensors="pt",
            padding=True,
            truncation=True,
            max_length=512
        )
        with torch.no_grad():
            outputs = self.model(**tokenized, output_hidden_states=True)
        last_hidden = outputs.hidden_states[-1]
        pooled = last_hidden.mean(dim=1)
        embeddings = pooled.cpu().tolist()
        return embeddings

EMBED_MODEL_NAME = "sentence-transformers/all-MiniLM-L6-v2"
embed_function = EmbedFunction(EMBED_MODEL_NAME)

# Use a temporary directory for persistent storage.
temp_dir = tempfile.mkdtemp()
print("Using temporary persist_directory:", temp_dir)

client = chromadb.Client(
    settings=Settings(
        persist_directory=temp_dir,
        anonymized_telemetry=False
    )
)

# Create or get the collection. Use a clear name.
collection = client.get_or_create_collection(
    name="ai_medical_knowledge",
    embedding_function=embed_function
)

# Force initialization: add a dummy document and perform a dummy query.
try:
    collection.add(documents=["dummy"], ids=["dummy"])
    _ = collection.query(query_texts=["dummy"], n_results=1)
    # Optionally, remove the dummy document if needed (Chromadb might not support deletion, so you can ignore it)
    print("Dummy initialization successful.")
except Exception as init_err:
    print("Dummy initialization failed:", init_err)

def index_pubmed_docs(docs: List[str], prefix: str = "doc"):
    """
    Adds documents to the Chromadb collection with unique IDs.
    """
    for i, doc in enumerate(docs):
        if doc.strip():
            doc_id = f"{prefix}-{i}"
            try:
                collection.add(documents=[doc], ids=[doc_id])
                print(f"Added document with id: {doc_id}")
            except Exception as e:
                print(f"Error adding document id {doc_id}: {e}")
                raise

def query_similar_docs(query: str, top_k: int = 3) -> List[str]:
    """
    Retrieves the top_k similar documents from Chromadb based on embedding similarity.
    """
    results = collection.query(query_texts=[query], n_results=top_k)
    return results["documents"][0] if results and results["documents"] else []

#############################################
# 3) MAIN RETRIEVAL PIPELINE
#############################################
def get_relevant_pubmed_docs(user_query: str) -> List[str]:
    """
    End-to-end pipeline:
      1. Fetch PubMed abstracts for the query.
      2. Index them in Chromadb.
      3. Retrieve the top relevant documents.
    """
    new_abstracts = fetch_pubmed_abstracts(user_query, max_results=5)
    if not new_abstracts:
        return []
    index_pubmed_docs(new_abstracts, prefix=user_query)
    top_docs = query_similar_docs(user_query, top_k=3)
    return top_docs