document: in GBMs is generally attributed to the hypoxic tumour microenvironment, which creates insufficient oxygen supply thereby rendering tumours highly resistant to radiation-induced killing through rapid DNA repair.4,5 Previous studies have also suggested that CD133-positive tumour cells represent the cellular population that confers glioma radiation resistance and could be the source of tumour recurrence after radiation.6,7 In addition, chemotherapy and radiation therapy-induced stress can lead to