document: with control and TrQβ VLPs groups. However, the TrQβ@b-3WJsiEGFR Let-7g showed higher gene silencing efficiency for IKKα and NF-κB (P65) than rQβ@b-3WJsiEGFR Let-7g because the TAT peptides on TrQβ@b-3WJsiEGFR Let-7geffectively increase tumour cell uptake and penetration (Figure 5c). Subsequently, the gene silencing efficiency of TrQβ@b-3WJsiEGFR Let-7gfor EGFR and NF-κB in U87MG cells was also confirmed by immunofluorescence staining, the EGFR expression (green fluorescence) on cell membrane