document: into mature miRNAs.31 To date, Northern blotting is a promising tool to observe the intracellular cleavage status of RNA with Dicer enzyme. In this study, to determine when the delivered b-3WJsiEGFR siLUC is cleaved in cells by Dicer enzyme, the extracted RNAs from cells with different treatments were analysed by Northern blotting. From 10% urea-PAGE stained with SYBR green II, the RNA signal was detected in all cell samples with different treatments (Figure 4a, Lanes 2-7). Using a