document: down the tumour cell growth rate, not directly kill tumour cells (Figure S20). Significant tumour growth inhibition was observed (18.9 ± 17.8 mm3 on Day 34) compared with the 2Gy X-ray irradiation group when the mice received 5 μL of carboplatin via CED infusion followed by 2Gy X-ray irradiation, most likely because carboplatin is known to sensitize cells to X-rays by enhancing the generation of DSBs and persistent single-strand breaks (SSBs).41 However, slight recurrence was observed after 34