document: Therefore, we replaced siLUC with Let-7 g miRNA in the 3WJ RNA scaffold and performed the production, named rQβ@b-3WJsiEGFR Let-7g (Figure 5b). The obtained rQβ@b-3WJsiEGFR Let-7g modified with TAT peptides on the surface (TrQβ@b-3WJsiEGFR Let-7g) can still emit green fluorescence in the presence of DFHBI-1T, indicating that the structure of b-3WJsiEGFR Let-7g still folded correctly after sequence exchange (Figure S8) and could be protected from RNase A degradation for more than 1 h (Figure S9).