document: RNA stability is one of the important factors affecting the success or failure of RNA interference (RNAi) therapy. However, packaging in rQβ VLPs protects b-3WJsiEGFR siLUC against urea-mediated denaturation and RNase A-mediated cleavage. We incubated rQβ@b-3WJsiEGFR siLUC with urea and RNase A and then mixed it with DFHBI-1T to assess the integrity of the b-3WJsiEGFR siLUC structure. After 144 h of incubation in the biological urea concentration (10 mM) urea at 37 °C, the b-3WJsiEGFR siLUC