document: compared with the control and TrQβ VLPs-treated groups (Figure 5a). Moreover, TrQβ@b-3WJsiEGFR siLUC also showed excellent inhibition of EGFR expression, and approximately 91% expression of EGFR was suppressed in U87MG cells compared with the control group (Figure S7). The overall results indicate that inhibition is caused by delivered b-3WJsiEGFR siLUC, but not by TrQβ VLPs, and the TrQβ@b-3WJsiEGFR siLUC can simultaneously downregulate two target genes.