document: after 0.5, 1, and 2 h of CED infusion. For brain tissue damaging situation evaluation, brain tissues from the mice after 5 days of different treatments [5 μL saline, 5 μL TrQβ VLPs (5 μM), and 5 μL TrQβ@b-3WJsiSCR MG (5 μM)] were stained by hematoxylin and eosin (H&E).