document: 41). No obvious improvement in survival rate was observed (median survival = 31 days for both groups) compared with the control and TrQβ VLPs-treated groups by the log-rank analysis (Table S1), indicating that (1) the 2Gy X-ray may not cause enough double-strand breaks (DSBs) and that the cells still process DNA repair to promote tumour cell growth, (2) the TrQβ@b-3WJsiEGFR Let-7g can only perform gene silencing to inhibit the DNA repair and slow down the tumour cell growth rate, not directly