document: down the target genes in primary and/or recurrent tumours. RNA nanotechnology has been growing rapidly as a new generation platform for specific RNA target suppression.10 As nanotechnology rapidly evolves, encapsulation of small interfering RNA (siRNA) in nanoparticles is a promising way to improve the effectiveness of siRNA for cancer treatment using lipid-,11 polymer-,12 metal-,13 and virus-14 based nanoparticles. However, the application of nanoparticle-encapsulated siRNA is confined by its