document: nanoparticle-encapsulated siRNA is confined by its low targeting efficiency, chemical and thermodynamic instability, and poor biocompatibility.15 Currently, three-way junction (3WJ) RNA nanoparticles to deliver microRNA (miRNA)/silencing RNA (siRNA) have been reported to address thermodynamic instability issues.16 The thermodynamically stable 3WJ motif derived from the bacteriophage phi29 DNA packaging motor (pRNA) core is composed of three oligos with a branched structure.17 In particular,