document: However, slight recurrence was observed after 34 days of treatment (55.2 ± 36.5 mm3 on Day 41), most likely because carboplatin has only the function of enhancing the generation of DSBs without the ability of DNA repair inhibition. Only one of the ten mice (10%) that received CED infusion of two doses of carboplatin at a volume of 5 μL for each followed by 2Gy X-ray irradiation survived over 54 days (median survival = 51 days). Even so, its therapeutic efficiency is still better than that of