document: When the RNA duplex is delivered into the cells, the ribonuclease (RNase) III enzyme Dicer processes double-stranded RNAs (dsRNAs) into 21-22-nt-long duplexes with 2-nt 3′overhangs, guiding sequence-specific degradation of complementary messenger RNAs (mRNAs) once incorporated into the RNA-induced silencing complex (RISC).30 Dicer-2 (Dcr-2) processes long double-stranded precursors and generates siRNAs, while Dicer-1 (Dcr-1) processes pre-miRNAs into mature miRNAs.31 To date, Northern blotting