document: Next, we assessed the gene silencing ability of TrQβ@b-3WJsiEGFR siLUC to EGFR and luciferase in luciferase-expressing U87MG cells. Incubation of luciferase-expressing U87MG cells with TrQβ@b-3WJsiEGFR siLUC decreased the expression of luciferase, as shown by bioluminescence imaging and Western blot analysis. The results show that incubation in 1 μM TrQβ@b-3WJsiEGFR siLUC for 72 h efficiently knocked down approximately 55% of luciferase expression compared with the control and TrQβ VLPs-treated