document: incubation time increased. By comparison to the sample from the cells incubated with Qβ@b-3WJsiEGFR siLUC for 24 h (Figure 4b, Lane 4), the large fragments of b-3WJsiEGFR siLUC significantly decreased, while the small fragments significantly increased after an additional 48 h of incubation (Figure 4b, Lane 7 and Figure 4c), indicating that the delivered b-3WJsiEGFR siLUC could be released from Qβ@b-3WJsiEGFR siLUC and then cleaved by the Dicer enzyme to specifically degrade the complementary