document: Nuclear factor kappa B (NF-κB) is well established to be activated in response to a variety of DNA lesions, such as TMZ-induced SN1 methylation, cisplatin-induced DNA cross-linking, and IR-induced double-strand breaks (DSBs).33,34 Inhibition of NF-κB increases the sensitivity of cancer cells to the apoptotic action of chemotherapeutic agents and radiation exposure.35 In humans, the IkB kinase (IKK) complex serves as the master regulator for the activation of NF-κB by various stimuli. The IKK