document: increased nearly 1.5-fold to 194% when the mice received the combination of TrQβ@b-3WJsiEGFR Let-7g pre-treatment with 2Gy of X-ray irradiation, which means that the TrQβ@b-3WJsiEGFR Let-7g can enter tumour tissue cells more efficiently compared with rQβ@b-3WJsiEGFR Let-7g, and the therapeutic efficiency of radiotherapy was substantially promoted by TrQβ@b-3WJsiEGFR Let-7g-based gene-silencing-enhanced radiotherapy. Finally, the toxicity of Qβ VLP-based therapeutics (TrQβ VLPs and