document: expression (green fluorescence) on cell membrane was significantly downregulated by TrQβ@b-3WJsiEGFR Let-7gand much lower than that by rQβ@b-3WJsiEGFR Let-7g (Figure 5d). Not only that, the translocation of NF-κB to the nucleus of U87MG cells was also significantly inhibited (no green fluorescence exhibited in nucleus) after treatment with TrQβ@b-3WJsiEGFR Let-7g compared with control (PBS), TrQβ VLPs, and rQβ@b-3WJsiEGFR Let-7g treated groups (Figure 5e). We then quantified the gene silencing