document: GBMs respond to DNA damage induced by ionizing radiation (IR) and TMZ treatment through increased expression of DNA repair enzymes, including the proteins O-6-methylguanine-DNA methyltransferase (MGMT) and poly(ADP-ribose) polymerase 1 (PARP-1).9 Thus, there is an urgent need to quickly identify the molecular basis of therapy resistance in the primary tumours of GBM patients and develop strategies to abrogate the repair by effectively knocking down the target genes in primary and/or recurrent