document: RNase A degradation for more than 1 h (Figure S9). To verify the effectiveness of TrQβ@b-3WJsiEGFR Let-7g in the downregulation of NF-κB for enhanced radiotherapy, the expression of EGFR and NF-κB, and the translocation of NF-κB to the nucleus was confirmed by Western blotting and immunofluorescence staining. The results show that both rQβ@b-3WJsiEGFR Let-7gand TrQβ@b-3WJsiEGFR Let-7gcan downregulate the expression of IKKα and NF-κB (p65) compared with control and TrQβ VLPs groups. However, the