document: The abovementioned promising in vitro outcomes instigated our exploration into whether TrQβ@b-3WJsiEGFR Let-7g performed well in vivo. In the first, we investigated the gene silencing efficiency of rQβ@b-3WJsiEGFR Let-7g and TrQβ@b-3WJsiEGFR Let-7g to downregulate the expression of NF-κB by Western blot analysis and immunohistochemistry. The results demonstrated that the concentration of NF-κB in tumour tissue cells can be reduced when the tumour-bearing mice received one dose of rQβ@b-3WJsiEGFR