document: siLUC with U87MG cells in the presence of DFHBI-1T allowed us to monitor the distribution of TrQβ@b-3WJsiEGFR siLUC and the cleavage status of b-3WJsiEGFR siLUC simultaneously in cells using a fluorescence microscope. As shown in Figure 4e, a large amount of TrQβ@b-3WJsiEGFR siLUC was endocytosed into U87MG cells to exhibit strong red fluorescence (TrQβ VLPs) and green fluorescence (b-3WJsiEGFR siLUC) after 24 h of incubation, indicating the b-3WJsiEGFR siLUC can be indeed delivered into tumour