document: 1c, left) and DFHBI-1T (Figure 1c, right). The results demonstrated that the b-3WJsiSCR MG was successfully packaged inside, and the structure folded correctly because the broccoli aptamer in the scaffold reacted with DFHBI-1T to emit a green fluorescence band at 237 nt. Furthermore, the reactivity of Qβ@b-3WJsiSCR MG with DFHBI-1T and MG was verified by incubating Qβ VLPs or Qβ@b-3WJsiSCR MG with DFHBI-1T and MG solution. As shown in Figure 1d and 1e, only Qβ@b-3WJsiSCR MG can react with