document: VLP can be designed using a variety of methods. First, different types of viruses can be selected as templates according to requirements. For example, if we want to deliver RNA, we can use RNA viruses to make this VLP. By selecting only the capsid protein sequence of RNA virus, the main structure of this VLP can be made. In terms of RNA design, the original virus packaging system (package binding site) can be used to fuse to the target RNA sequence to obtain an RNA with automatic packaging