document: the cell viability of U87MG cells through the pre-treatment with TrQβ@b-3WJsiEGFR Let-7g for 72 h followed by 2Gy X-ray irradiation was decreased to 8.7 ± 3.4% compared with the 2Gy X-ray irradiated group (cell viability: 41.6 ± 4.9%) and rQβ@b-3WJsiEGFR Let-7g + 2Gy X-ray irradiated group (cell viability: 28.7 ± 5.4%). These findings indicate that the b-3WJsiEGFR Let-7g can be efficiently delivered by TrQβ VLPs to perform dual-target gene (EGFR and IKKα) silencing for further radiotherapy