document: of TAT peptides on Qβ@b-3WJsiEGFR siLUC to form TQβ@b-3WJsiEGFR siLUC. Subsequently, we incubated the U87MG cells with rQβ@b-3WJsiEGFR siLUC and TrQβ@b-3WJsiEGFR siLUC to compare their ability of getting into the cells. The distributions of TrQβ VLPs (red fluorescence) and b-3WJsiEGFR siLUC (green fluorescence) were both markedly higher in the whole tumour spheroid and can penetrate deeper into the tumour spheroid than in the absence of TAT peptide-modified rQβ@b-3WJsiEGFR siLUC (Figure 3g),