document: reported to directly knocks down MEKK1, IKKα and ablates IKKα phosphorylation.45 Thus, we incorporate one EGFR siRNA sequence and one Let-7g sequence into the 3WJ RNA scaffold to obtain TrQβ@b-3WJsiEGFR Let-7g. We found that silencing those proteins of EGFR and IKKα, using TrQβ@b-3WJsiEGFR Let-7g enabled RNAi, reduced overall NF-κB expression and activity in the nucleus resulting in a suppression of DNA repair after radiotherapy. Our in vivo data provide a proof of principle that the designed