document: repair of DSBs after IR. The possible mechanism is that the downregulation of EGFR inhibits the expression of the IKK complex thereby inactivate NF-κB signalling to inhibit DNA repair38 but it remains to be determined in detail. Our second target, IKKα, forms the catalytic subunit with IKKβ to regulate subunit IKKγ thereby promoting IKK complex production. The IKK complex is a central regulator of NF-κB activation. Let-7g, a miRNA, has been reported to directly knocks down MEKK1, IKKα and