document: and self-packaging, (2) multigene silencing, (3) real-time monitoring of intracellular RNA cleavage by Dicer enzyme using fluorescence microscopy, (4) RNA stability enhancement, and (5) great biosafety. Herein, we incorporated EGFR siRNA and miRNA Let-7 g into the 3WJ RNA scaffold to produce rQβ@b-3WJsiEGFR Let-7g, which was delivered to tumour tissues through the convection-enhanced delivery (CED) method to overcome the blood-brain barrier (BBB) challenge and enhance radiotherapy in GBMs