document: According to 2018 statistics of the American Cancer Society, an estimated 1,735,350 new cases of cancer will be diagnosed in the United States and 609,640 people will die from the disease. UCs are the fifth most common tumors (Siegel et al., 2018; Bray et al., 2018). They can be located in the lower (bladder and urethra) or upper (pelvicalyceal cavities and ureter) urinary tract. BC accounts for 90–95% of UCs and are the most common malignancy of the urinary tract (Babjuk et al., 2013). By