document: IKKα simultaneously and thereby inactivate NF-κB signalling to inhibit DNA repair. Delivery of TrQβ@b-3WJsiEGFR Let-7g through convection-enhanced delivery (CED) infusion followed by 2 Gy X-ray irradiation demonstrated that the median survival was prolonged to over 60 days compared with the 2 Gy X-ray irradiated group (median survival: 31 days). Altogether, the results of this study could be critical for the design of RNAi-based genetic therapeutics, and CED infusion serves as a powerful