document: than the pore size of the rQβ VLPs.32 There was no detectable intact b-3WJsiEGFR siLUC remaining after the same incubation time for naked b-3WJsiEGFR siLUC under the same conditions (Figure S6b). Taken together, the results show that packaged RNA in rQβ VLPs degrades slowly at 37 °C in the presence of urea and RNase A without complex structural modifications that has considerable potential for the development of nucleic acid drugs.