document: activation of NF-κB by various stimuli. The IKK complex consists of IKKα and IKKβ, which form the catalytic subunit, and the regulatory subunit IKKγ.36,37 Previous reports pointed out that the downregulation of EGFR expression would affect RIPK1/TAK-1/TRAF2 message transmission and thus inhibit the expression of the IKK complex.38 Let-7 g cleaves IKKα mRNA and may play an important role in the response to IR through the inhibition of NF-κB.39 Therefore, we replaced siLUC with Let-7 g miRNA in