document: TrQβ@b-3WJsiEGFR Let-7g showed a robust ability to protect packaged RNA scaffolds from unwanted threats (i.e., enzymatic digestion), high tumour cell penetration efficiency, and surrounded the whole tumour with a high concentration of b-3WJsiEGFR Let-7g by CED infusion, which can bypass the blood-brain barrier BBB to reduce systemic toxicity. Conspicuously, these genetic therapeutics provide a chance to serve as a powerful gene-silencing-enhanced radiotherapy for clinical GBM treatment and other