document: the scaffold, named b-3WJsiSCR MG (Figure 1a). The b-3WJsiSCR MG and Qβ capsid were co-expressed in a dual-plasmid E. coli expression system (Figure S2a). After induction using IPTG, the transcribed b-3WJsiSCR MG with Qβ hairpin on the 5΄ end and translated Qβ capsids self-assembled into Qβ VLPs with b-3WJsiSCR MG self-packaged inside, named Qβ@b-3WJsiSCR MG. Packaging of the b-3WJsiSCR MG in the capsid left the morphology of the Qβ@b-3WJsiSCR MG unchanged and showed uniform size distribution