document: treatments (Figure 4a, Lanes 2-7). Using a biotin-conjugated DNA probe complementary to the siEGFR strand of b-3WJsiEGFR siLUC, only the samples from the cells treated with Qβ@b-3WJsiEGFR siLUC still exhibited an obvious RNA signal (Figure 4b, Lanes 4-7), indicating that Qβ@b-3WJsiEGFR siLUC can be internalized into cells and release b-3WJsiEGFR siLUC. Furthermore, the delivered b-3WJsiEGFR siLUC began to be cleaved into small fragments as the incubation time increased. By comparison to the