document: provide a proof of principle that the designed 3WJ RNA enables to simultaneously block different signalling pathways of DNA repair mechanisms to enhance cellular response to X-ray irradiation thereby eradicating the tumour of GBMs and supressing tumour recurrence. Owing to the modular character of b-3WJ RNA scaffold, this approach can be adapted for silencing any other genes (i.e., Akt, Bcl-xL, VEGF, TNFα, STAT3, and et al.) by inserting different target sequences of siRNA/miRNA into b-3WJ RNA