 discretion.
The United States District Court for the Eastern District of Missouri, in a minority shareholders' appraisal proceeding, discussed the history, operations, and "fair value" of Siegel-RobertSee Swope v. Siegel-Robert, Inc., 74 F.Supp.2d 876, 879-910 (E.D.Mo.1999), aff'd in part and rev'd in part by 243 F.3d 486 (8th Cir.2001). In our review of that opinion, we held it was not appropriate under Missouri law, in the context of unwilling minority sellers' appraisals, to discount the value of shares due to a lack of marketability or due to minority shareholder status. Swope, 243 F.3d at 496-97. The issue before the court was the "fair value" of the minority shares rather than the "fair market value," which would have included market considerations such as minority status and the lack of willing buyers. See id. at 493 ("Because `fair market value' is irrelevant to the determination of fair value, market forces, such as the availability of buyers for the stock, do not affect the ultimate assessment of fair value in an appraisal proceeding."). Because of this difference, we determined that an IRS appraisal prepared for estate tax purposes was not relevant in the context of that appraisal proceeding. See id. at 498 ("Regardless, appraisals for estate tax purposes are not relevant to the determination of fair value pursuant to a dissenters' appraisal proceeding."). We nevertheless refer the reader to the Swope opinions because we do not set out the same detailed review of the corporation's history in this opinion.CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity.

Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host defense against pathogens. One subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, we demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole.Transformation of NHS face-to-face sexual health clinic to digital service in 8 weeks
Online sexual health testing service to tackle high clinic demand
- 8 weeks from an idea to a working online service
- 16 weeks from inception to NHS approved service
- 95% of people who start the order process go through to completion
- 60,000+ test kits ordered to date
SH:24 in numbers
1,600+
Orders dispatched per week
60,000+
Test kits ordered to date
Taking the process from the doctor’s waiting room to online
Following a string of negative headlines and a rise in STI rates in the Lambeth and Southwark areas, SH:24 came to us with an idea for a digital service: An online sexual health testing service for 620,000+ local residents. The vision was a self-service testing kit, ordered online, to tackle long queues at sexual health centers and dramatically increase public access to these services.
From the moment we met Unboxed, we felt they understood our approach and had a robust process for exploration and delivery.
Chris Howroyd, Director — SH:24
'Moving in' next door to users and partners
We co-located with the SH:24 part of the team in their offices in Lambeth for the discovery and alpha phases. Our location, close to the clinics, gave us direct access to the service users and our clinical partners. From the earliest sketches, through prototypes and models, to the final production code and kits, we were able to validate our thinking on a daily basis with real users of the service.
A new physical service with a digital core
Whilst the digital elements formed a critical part of the service, great care was taken to ensure that the experience of the physical product was equally as effective. The packaging and instructions, supporting information and messaging went through numerous iterations – for example the home blood sampling process changed radically and the instructions were tested and recreated several times.
Unboxed brought people together rapidly and helped us to deliver a full service in an incredibly short space of time.
Chris Howroyd, Director — SH:24
Building trust amongst stakeholders
Many different stakeholders had high hopes or deep concerns about the outcome of this mould-breaking project. So we held regular open workshops to establish enough trust to move fast. We identified the most significant issues first - patient record security and service quality – and directly addressed these immediately.
SH:24 in numbers since launch
78%
Kit return rate
98.4%
User satisfation rate
100+
Users involved in the design
95%
People starting the order process through to completion
Live service launched in 16 weeks
After just 8 weeks, users were able to order and complete an STI test at home, without any clinical support. A further 8 weeks and this live service was scaled and launched to the public, resulting in over 60,000+ tests being ordered to date. With a result pleasing users and stakeholders alike, SH:24 has rolled out across a further six UK areas. SH:24 won the 'Best User Experience’ award at the User Experience UK (UXUK) Awards 2016.
A great team with exactly the right mix of skills we needed.
Chris Howroyd, Director — SH:24
Unboxed team
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About the BlogHer Book Club
By Karen Ballum on March 29, 2011
Featured Member Post
BlogHer is thrilled to be collaborating with Penguin Group USA to bring you reviews of great upcoming books, author interviews, book discussions and much more! They’re all part of our new BlogHer Book Club. What's exciting about this partnership: BlogHer is paying writers to write balanced, editorial reviews of the BlogHer Book Club featured titles. Here's how it works.
Reviewers
Book Club Host Karen Ballum will recruit reviewers from our list of excellent writers. Each reviewer will receive a copy of the book and be paid to write and publish her editorial opinion of the book here for community discussion. We're excited about the diversity of opinions and perspectives we can bring to Penguin's list -- and we'll keep talking about other publisher titles, of course, in our ongoing BlogHer Book Chat group. Stay tuned for information on how to join our reviewer program.
Books
We firmly believe that there is a perfect book out there for everyone. BlogHer and Penguin are working together to select two books a month that will speak to you, our community. We'll be featuring both fiction and non-fiction titles on a variety of topics – perfect to give you insight into authors you love and new voices to discover.
Authors
We’re working with Penguin to bring