 solutions, educational programs like those offered by the SIPfoundry are an absolute necessity.
“Converged communications are finally ready to compete head-to-head with traditional communications solutions, and programs like the open source sessions hosted by SIPfoundry are invaluable to developers building the next-generation of telecom applications,” explained Tehrani.
“TMC’s brand-new VoIP Developer Conference, and the established INTERNET TELEPHONY Conference & EXPO (being held for the 10th time this October), are premier events for educating industry and business/institutional users to the benefits derived from the integration of voice, data, fax and video. Together, the TMC and SIPfoundry programs address one of the most important drivers of that convergence,” added Tehrani.
SIPFoundry, a non-profit organization, is the leading open source enterprise communications community development project. It is organized under the Massachusetts Nonprofit Mutual Benefit Corporation Law for the mutual benefit of the developers, distributors and customers of open source software products and services. SIPfoundry is grounded in the belief that open source will deliver a fundamental change to the enterprise communications market, enabling market forces, not individual companies, to set the pace of innovation and product development. The mission of SIPfoundry is to promote and advance SIP-related Open Source projects, and to establish a mechanism whereby users, developers, and distributors of those projects can contribute to the adoption of SIP. The open source model is built on the premise that allowing the best technology to win in an open, competitive environment is better for the entire market eco-system. For more information, please visit www.sipfoundry.org.
Celebrating more than 30 years as a leading technology publisher, Technology Marketing Corporation (TMC) produces industry-leading trade magazines and events focused on technology and communications. TMC publishes two magazines: Customer Inter@ction Solutions, and Internet Telephony, and the online publications, TMCnet.com, WiFitelephony.com, The VoIP Developer Channel, Planet PDA? Magazine, Alternative Power and BiometriTech. TMC is also the first publisher to test new products in its own on-site laboratories, TMC Labs, and provide factual and unbiased product reviews. TMC produces INTERNET TELEPHONY Conference & EXPO, The VoIP Developer Conference and The Global Call Center Outsourcing Summit. TMCnet.com publishes more than 25 topical online newsletters. For more information about TMC, visit its Web site at www.tmcnet.com.How in the world is it already mid-August and how in the world is our wedding only two weeks away. I’m sure this is a sentiment that most people have before their wedding — Where did the time go?!
Well, with the wedding almost here, I thought I’d share some snaps from our engagement shoot a few weeks back. I never wanted to do an engagement shoot. Truth be told, I think they are a bit strange… but I’ve come around to them. I feel like most people planning weddings are a bit more in the “wedding” state of mind early in the process. It seems like everyone has their colours and themes figured out, they have their wedding party planned as soon as they say “yes.” They book their venue a year or two in advance and shortly thereafter, book their photographer.  Of course, I know that not everyone does this and this clearly hasn’t been our experience. I only really came around to that “wedding” state of mind about a month and a half ago… so we booked a DJ, photographer and set a wedding party.
I did a call out to my Bunz community for some help finding a photographer and there came Boeun! We loved her style and decided to go for it. Included in the package was an engagement session so we did it. Honestly, I was so awkward when the session started up and by the end, I felt a lot more at ease. Boeun was fantastic. She suggested some poses but overall we were just being ourselves. We recreated one of our typical beach days which have been a bit few and far between this summer on the account of I couldn’t make get down to the beach, but we took our time and made it work.
Next Post That time we got married!
2 weeks! i’m not ready yet!
so who won at chess?
Most excellent photos there, the photographer captured both of you in a pre wedding atmosphere. Do make a small album of them all and keep as special moment in your lives.
Finally a good excuse to use fortnight in regular speech! I agree that a lot of token professional photos seem weird to do, but I think the idea is that it’s a favour to your future self, even if it feels a little awkward at present. I don’t think my mom was dying to have her ’80s haircut immortalized in wedding photos (and didn’t appear super happy about it in them) but those are such treasured albums now. Here’s to what you guys will be saying about these shots in 20 years!
Viruses require entry into host cells for replication. This process involved attachment of the virus to host cell surface receptors, entry into the cell by endocytosis, and viral uncoating to release the viral genome into the cytoplasm.
Entry of SARS-CoV-2, the coronavirus that causes COVID-19, into host cells is mediated by binding of spike (S) protein to ACE2, expressed on the host cell surface. The S protein on the surface of SARS-CoV-2 is the largest protein within the virus and is heavily glycosylated. It consists of S1 and S2 domains, responsible for host cell binding and membrane fusion, respectively. The S protein forms extended trimeric structures that give this coronavirus its classical 'crown' shape, and disruption of S protein glycosylation has been shown to impair viral cell entry.
A key difference between the S protein on SARS-CoV-2 and SARS-CoV, the cause of a previous outbreak of severe acute respiratory syndrome (SARS) in 2002-2004, is the presence of a cleavage site for furin at the SARS-CoV-2 S1/S2 boundary. This differs from SARS-CoV, where S1/S2 cleavage is catalyzed by cathepsins (Figure 1). This difference is thought to be a factor in enhanced infectivity of SARS-CoV-2 compared to SARS-CoV, as the furin cleavage sequence fits the 'C-end rule' (CendR), by generation of RRAR binding motif at the C-terminal of S protein, enabling binding of the S protein to neuropilin-1 (NRP1). NRP1 is a membrane-bound co-receptor for VEGF and semaphorin receptor tyrosine kinase families, the expression of which promotes infection of SARS-CoV-2 in human cell lines. The NRP1 antagonist EG 00229 (Cat. No. 6986) inhibits NRP1-S binding and reduces infectivity in vitro.
Figure 1: Comparison of viral cell entry mechanisms of SARS-CoV-2 and SARS-CoV, showing SARS-CoV-2 S protein binding to NRP1.
ACE2 is a transmembrane protease and its primary function is to cleave vasoactive peptides of the renin-angiotensin system. The S protein receptor binding domain (RBD) in the S1 ectodomain binds to the extracellular enzymatic domain of ACE2, resulting in endocytosis and translocation of the virus and ACE2 into the host cell. For both SARS-CoV and SARS-CoV-2, priming of the S2 domain is required for fusion to the host cell. This is performed by TMPRSS2, a host serine protease. TMPRSS2 is coexpressed with ACE2 on human bronchial epithelial cells, a key site of SARS-CoV-2 infection in COVID-19. It has been shown that camostat (Cat. No. 3193), an orally active non-selective protease inhibitor, can partially block entry of SARS-COV-2 into lung cells in vitro, by inhibiting TMPRSS2.
Other coronaviruses utilize different transmembrane proteases as their host cell receptor, for example MERS-CoV binds to dipeptidyl peptidase 4 (DPP-IV; CD26) and HCoV-229E binds to aminopeptidase N.
Following fusion to the host cell membrane, the viral genome is released into the cytoplasm. At this point the virus co-opts the transcription and translation machinery of the host cell to replicate itself.
Tocris offers the following scientific literature for Viral Cell Entry to showcase our products. We invite you to request* or download your copy today!
This brochure provides an overview of our knowledge of the virus and highlights products available from Bio-Techne to enable research into finding a treatment.Napoli’s lawyer calls Amin Younes’ declarations “astonishing and disconcerting”, stating that he gave “a total of 31 signatures” for his move from Ajax.
The German international was all set to sign for the Partenopei in January, but changed his mind and went back to the Netherlands, ostensibly to be close to his ill grandfather.
However, it now appears that he has changed his mind about joining when his contract expires on June 30, and he claimed today that he hasn’t signed for Maurizio Sarri’s side.
“Younes’ declarations are astonishing and disconcerting, especially considering that he is a player of the German national team and Ajax,” Napoli’s lawyer Mattia Grassani said on Radio Kiss Kiss Napoli.
“You could almost smile, were it not for the fact that in the