Welcome to The Weekender where we have a big bumper episode packed with prizes and a look at the world of Age of Tyrants! If you like the idea of combined arms combat then stay tuned for our interview.
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Age of Tyrants, it's a start!
Today starts (6pm GMT) the Kickstarter of Age of Tyrants, the new project in the VOID / Urban Wars universe. I'm quite excited about this as I have always been a fan of this universe.
Ok first sample then to celebrate the starting of the KS later today: a Junker Venator!
Age of Tyrants : La campagne de financement participatif ouvre le feu demain a 19H sur Kickstarter!!! Aux Armes!!!
This time we are there!! After being pushed back a few days, the official campaign of AGE OF TYRANTS starts with a bang tomorrow night at 19h (French time)!!!
The Syntha infantry 3d models are now available to preview in SketchFab.Sub zero and forced subtitles in general

I have used an htpc since 2012, first xbmc then pht, now plex media player. This software can always recognized forced pgs subtitles in my blu ray files. 

However hdr on an htpc is limited to madvr and not working in plex media player. So i looked at a zappiti player which does not support forced pgs subtitle detection.

Honestly i dont know how anyone can bother with remuxing subtitles themselves or finding them, but I came across sub zero.

It works mostly for movies, but game of thrones blu ray has forced subtitles, it wont find any. And  i looked online and I cant even find them manually. Is their simply no real good resource for forced tv show subtitles? If so I have to stick with plex media player htpc and hope he figures out hdr.We will bring you to our main three attractive destinations.
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At Macgad, we look forward to individuals who have the creativity and ability in providing solution to everyday work challenge. We believe that determination to learn and gain lesson are of the same importance with experience. Apart from a group of young people who love to have fun, we turn our working environment into a lively atmosphere.+ The patient is a 14-year-old male who was initially presented at age 12 years 4 month with anemia, leukocytosis, and splenomegaly, when he was diagnosed with juvenile myelomonocytic leukemia (JMML). Chromosome analysis of bone marrow revealed loss of chromosome 7 (45,XY,-7). The patient achieved complete remission after bone marrow transplantation from a female donor following chemotherapy. At the follow-up visit, 7.5 months after BMT and 10 month after initial visit (AIV), he was found to have 31% blasts in his peripheral blood smear. Bone marrow evaluation was consistent with acute myeloid leukemia (AML) arising out of JMML. Eighteen months AIV the karyotype of 45,XY,-7[9]/45,Y,i(X)(q10),-7[11] was recorded. Chromosome analysis of bone marrow samples 21 and 23 month AIV showed similar karyotypes.
Hypercellular bone marrow (100%), with normal number of megakaryocytes with dyspoiesis, decreased erythropoiesis, increased and left shifted granulopoiesis, and 16% blasts.
Multicolor flow cytometric analysis reveals two abnormal populations: The first abnormal population was 36% large monocytic cells with the following immunophenotype: bright CD11b+, heterogeneous CD13+, CD14+, dim CD15+, heterogeneous CD16+, CD33+, CD36+, CD38+, bright CD45+, bright CD56+, CD64+, partial dim CD71+, CD117+ and heterogeneous HLA-DR+. These cells were negative for CD7 and CD34. CD61 is uniformly positive. It was unclear if this was due to high background staining from platelets versus aberrant expression. The second abnormal population was 4% large myeloid blasts with the following immunophenotype: CD7+, CD11B+, CD33+, CD34+, dim CD45+, CD117+, heterogeneous CD38+, heterogeneous CD56+, partial dim CD71+, and heterogeneous HLA-DR+. These cells are negative for CD13, CD14, CD15, CD16, CD36, CD61, and CD64. The analysis also identified 7.6% granulocytes.
4% atypical myeloid blasts (with expression of CD7,CD11b, heterogeneous CD56, heterogeneous HLA-DR and heterogeneous CD38 and lack of CD13) and an increased population of atypical monocytic cells (36%) (with expression of bright CD56, CD117 and heterogeneous HLA-DR).
Acute myeloid leukemia (AML) arising out of juvenile myelomonocytic leukemia (JMML).
Initially patient was diagnosed with JMML. The splenectomy followed by 2 cycles (28 days each) of low dose chemotherapy (consistent of oral mercaptopurine, cis-retinoic acid, low dose cytarabine). This is followed by allogeneic bone marrow transplant from HLA matched unrelated female donor. Preparative (conditioning) myeloablative regimen performed with busulfan, fludarabine, antithymocyte globulin (ATG) and graft versus host disease prophylaxis with mycophenolate mofetil and tacrolimus. BMT was performed after 2.5 month AIV and neutrophil engraftment was on day +26 and platelet engraftment on day +24 post-transplant. After BMT the patient received multiple courses of different chemotherapy and immunotherapy in order to achieve remission. Secondary AML arising from JMML was diagnosed after 10 month AIV and standard induction chemotherapy for AML was started (A10D3E5 according to COG-AML1031), due to failure to achieve remission status different agents in different combinations were administered including the following: Azacitadine, oral mercaptopurine, decitabine, lenalidomide, cis-retinoic acid, low dose cytarabine, high-dose cytarabine and mitoxantrone, hydroxyurea. First i(X)(q10) appearance was recorded after 18 month. Eventually the patient underwent a second bone marrow transplant with a different donor 23 month AIV, conditioning with fludarabine and total body irradiation. He is currently awaiting count recovery.
45,XY,-7[9]/45,Y,i(X)(q10),-7[11]. Twenty cells were analyzed and two cell lines were detected. Nine (9/20=45%) cells (clone 1) had a modal number of 45 chromosomes, including the X and Y chromosomes. These cells were missing a chromosome 7 [45,XY,-7]. The remaining eleven (11/20=55%) cells (clone 2) had a modal number of 45 chromosomes, including a Y chromosome, an isochromosome of the long arm of X chromosome, and monosomy 7 [45,Y,i(X)(q10),-7].
Fluorescence in situ hybridization (FISH) studies were performed on 300 nuclei using the DNA probes D7S522/CEP 7 [7q31/7cen]. This probe detects the D7S522 deletion [del(7)(q31)] in a fluorescence in situ hybridization dual color assay on cultured cells. The frequency of nuclei with a monosomy 7 signal pattern was 95.0%.
DNA Testing for FLT3 and NPM1 Mutations: PCR.
FIGURE 1: Bone marrow karyotype with monosomy 7 and i(Xq).
Here we describe a 14 year old male patient who was initially diagnosed with JMML and a bone marrow karyotype of (45,XY,-7[20]). He developed AML 7.5 month post-BMT. After 18 month AIV the first i(X)(q10) detected. The karyotype of 45,XY,-7[9]/45,Y,i(X)(q10),-7[11] recorded on month 21 AIV. Structural anomalies of X chromosome in hematological malignancies (HM) are uncommon and occur in approximately 1-1.5% of patients (Dewald, GW. et al. 1989, Byrd, JC. et all 2002). The most common anomaly is isodicentric X with idic(X)(q13). The i(X)(p10) and i(X)(q10) are observed less frequently. Most isochromosome X, observed in HM are affecting females. The reported cases in males include i(X)(q10