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1 Department of Chemistry, Rutgers State University of New Jersey, New Brunswick 08903.
The observed sequence dependence of the mean twist angles in 38 B-DNA crystal structures can be understood in terms of simple geometrical features of the constituent base-pairs. Structures with low twist appear to unwind in response to severe steric clashes of large exocyclic groups (such as NH2-NH2) in the major and minor grooves, while those with high twist are subjected to lesser contacts (H-O and H-H). We offer a simple clash function that depends on base-pair morphology (i.e. the chemical constitution of base-pairs) and satisfactorily accounts for the twist angles of the ten common Watson-Crick dimer steps both in the solid state and in solution. The twist-clash correlation that we find here still holds when extended to modified bases. In addition to Calladine's purine-purine clashes, we add other close contacts between bases in the grooves, and consider the conformational restrictions on the geometry of the sugar-phosphate backbone (namely, we emphasize the tendency of DNA to conserve virtual backbone length). The significance of this finding is threefold: (1) sequence-dependent DNA twisting is directly involved in protein-DNA interactions; (2) strong correlation between Twist and Roll helps to elucidate the bending of the double helix as a function of base sequence; (3) it is possible to anticipate the effects of chemical modifications on twisting and bending. The mutual correlations of other structural parameters with the twist make this angle a primary determinant of DNA conformational heterogeneity.
Q: No realiza la acción "Llamada" al pulsar sobre "ImageButton" al concederle los permisos (Android 6+) Tengo un problema y es que quiero que me realice una llamada al pulsar sobre una "ImageButton" pero no lo hace con el código nuevo.
Código que tenía antes para realizar llamadas:
icon_des5.setOnClickListener(new View.OnClickListener() {
    @Override
    public void onClick(View v) {
        Intent i = new Intent(Intent.ACTION_CALL, Uri.parse("tel:0000000"));
        if(ActivityCompat.checkSelfPermission(MainActivity.this, Manifest.permission.CALL_PHONE)!=
        PackageManager.PERMISSION_GRANTED)
            return;
        startActivity(i);
        overridePendingTransition(R.anim.fade_in, R.anim.fade_out);
    }
});

El problema de ese código es que no me pedía los permisos en Android 6+, así que lo cambie por este:
final int MY_PERMISSIONS_REQUEST_CALL_PHONE = 10;

    @Override
    public void onRequestPermissionsResult(int requestCode, String permissions[], int[] grantResults) {
        switch (requestCode) {
            case MY_PERMISSIONS_REQUEST_CALL_PHONE : {
                if (grantResults.length > 0 && grantResults[0] == PackageManager.PERMISSION_GRANTED) {
                    // PERMISO CONCEDIDO, procede a realizar lo que tienes que hacer
                    Intent i = new Intent(Intent.ACTION_CALL, Uri.parse("tel:112"));
                } else {
                    // PERMISO DENEGADO
                }
                return;
            }
        }
    }

        icon_des5.setOnClickListener(new View.OnClickListener() {
            @Override
            public void onClick(View v) {
                if(ActivityCompat.checkSelfPermission(MainActivity.this, Manifest.permission.CALL_PHONE) == PackageManager.PERMISSION_GRANTED){
                    // Aquí ya está concedido, procede a realizar lo que tienes que hacer
                    Intent i = new Intent(Intent.ACTION_CALL, Uri.parse("tel:112"));
                }else{
                    // Aquí lanzamos un dialog para que el usuario confirme si permite o no el realizar llamadas
                    ActivityCompat.requestPermissions(MainActivity.this, new String[]{ Manifest.permission.CALL_PHONE}, MY_PERMISSIONS_REQUEST_CALL_PHONE);
                }
            }
        });

Y con este si me pide los permisos para realizar la llamada, pero no llama, no hace nada al pulsar sobre la ImageButton una vez concedido el permiso.
ManifestActivity:
public class MainActivity extends AppCompatActivity {

    ImageButton btn1;
    ImageButton btn2;
    ImageButton btn3;
    ImageButton btn4;
    ImageButton btn5;
    ImageButton icon_des1;
    ImageButton icon_des2;
    ImageButton icon_des3;
    ImageButton icon_des4;
    ImageButton icon_des5;
    ImageButton icon_des6;

    final int MY_PERMISSIONS_REQUEST_CALL_PHONE = 10;

    @Override
    public void onRequestPermissionsResult(int requestCode, String permissions[], int[] grantResults) {
        switch (requestCode) {
            case MY_PERMISSIONS_REQUEST_CALL_PHONE : {
                if (grantResults.length > 0 && grantResults[0] == PackageManager.PERMISSION_GRANTED) {
                    // PERMISO CONCEDIDO, procede a realizar lo que tienes que hacer
                    Intent i = new Intent(Intent.ACTION_CALL, Uri.parse("tel:112"));
                } else {
                    // PERMISO DENEGADO
                }
                return;
            }
        }
    }

    @Override
    protected void onCreate(Bundle savedInstanceState) {
        super.onCreate(savedInstanceState);
        setContentView(R.layout.activity_main);
        getSupportActionBar().setDisplayOptions(ActionBar.DISPLAY_SHOW_CUSTOM);
        getSupportActionBar().setCustomView(R.layout.text_des);

        