based, rather than Mac like my previous Instant Immersion software, was horrible -- very poorly organized, random, incoherent lessons with a terrible interface. The user is on their own for most of the lessons; they don't explain words in context (i.e., root word, verb, subject, etc.) I paid about $80 for this but would have been disappointed if it were $29.
A:
decreaseIt's in their self interest to live in a stable society that doesn't lead to a complete breakdown due to social and income inequality.

The problem is that a few millionaires alone can't make a difference. It would require all of the super wealthy to contribute, but we know that will never happen.

I know a guy who's a millionaire who said he hates people like Jeff Bezos who don't contribute much of their wealth back to society, because it leads to societal collapse (and look what happened when inequality got out of hand and the wealthy/educated were persecuted, like with the Chinese cultural revolution, Hitler's rise, French revolution, etc.) 

He mentioned he'd probably just move out of the country if things ever got that bad, but it requires not just a few millionaires to pay more taxes, it requires all of the wealthy to contribute equally.

It looks like history is set to repeat itself. Things do not look good for the US, and like George Carlin said 20 years ago, we're fucked.Hormonal Regulation of Oligodendrogenesis II: Implications for Myelin Repair.
Alterations in myelin, the protective and insulating sheath surrounding axons, affect brain function, as is evident in demyelinating diseases where the loss of myelin leads to cognitive and motor dysfunction. Recent evidence suggests that changes in myelination, including both hyper- and hypo-myelination, may also play a role in numerous neurological and psychiatric diseases. Protecting myelin and promoting remyelination is thus crucial for a wide range of disorders. Oligodendrocytes (OLs) are the cells that generate myelin, and oligodendrogenesis, the creation of new OLs, continues throughout life and is necessary for myelin plasticity and remyelination. Understanding the regulation of oligodendrogenesis and myelin plasticity within disease contexts is, therefore, critical for the development of novel therapeutic targets. In our companion manuscript, we review literature demonstrating that multiple hormone classes are involved in the regulation of oligodendrogenesis under physiological conditions. The majority of hormones enhance oligodendrogenesis, increasing oligodendrocyte precursor cell differentiation and inducing maturation and myelin production in OLs. Thus, hormonal treatments present a promising route to promote remyelination. Here, we review the literature on hormonal regulation of oligodendrogenesis within the context of disorders. We focus on steroid hormones, including glucocorticoids and sex hormones, peptide hormones such as insulin-like growth factor 1, and thyroid hormones. For each hormone, we describe whether they aid in OL survival, differentiation, or remyelination, and we discuss their mechanisms of action, if known. Several of these hormones have yielded promising results in both animal models and in human conditions; however, a better understanding of hormonal effects, interactions, and their mechanisms will ultimately lead to more targeted therapeutics for myelin repair.Recently, news stories circulated about incarcerated women in Arizona being denied access to menstrual products.
When we hear stories about prison conditions in the United States, people in Canada often believe that these injustices do not happen in our prisons and jails.
I have been hearing for a long time from women serving weekends in Central Nova Scotia Correctional Facility and their family members about the terrible conditions they are subjected to.
Women also allege that mental health services are not accessible over the weekends. One woman described how it took four years for her to be sentenced, and in that time the stress of her case resulted in significant mental and physical health challenges. During her weekend sentences, she experienced severe urges to self harm, but she was not able to talk to anyone.
Women have also reported that the weekend range is infested with ants. This problem has apparently existed for a long time, and is not improving. While the province is investing $1 million in body scanners, including two for use at the Central Nova Scotia jail, women are sleeping with ants crawling over their bodies, and they say they have been told that funds for extermination are limited. Women report that they have complained repeatedly, but nothing has been done.
The women also say they have no access to the day room while they are serving weekend time, so they cannot get books or other recreational products. One woman who is attempting to complete her GED during her sentence shared that although the GED books are available, she could not get a calculator to complete the math problems. Women also have had difficulty getting pens or paper. The inability to engage in basic activities like reading or writing to pass the time and occupy their minds also has a significant effect on the mental health of those serving sentences.
While the perception may be that since weekend sentences are “short” (Friday night to Monday morning), a couple of days without access to hygiene products or books or clean clothes is no big deal, denying women serving these sentences basic rights and dignity should not be acceptable just because they return to the community for the week. While no prisoner should be subjected to degrading conditions no matter what they are accused or convicted of, people serving weekends are convicted of extremely minor crimes, and many maintain jobs and are responsible for caring for children during the week. They should not be subjected to more severe conditions of incarceration just because they can shower or change on Monday.
Many women describe how the conditions they experience over the weekend significantly impact their mental health in the rest of their life — for example, one woman parenting a child with significant developmental challenges spoke about the difficulty of spending the weekend suffering in jail, and then spending the week at the hospital with her child while struggling with depression and anxiety caused by the conditions during her sentence.
Because they must return to the jail every weekend for their sentences, and because many of them feel their employment or custody is vulnerable because of their record, these women are afraid to speak out about the conditions they face in case they experience retaliation. Women reasonably fear that if they complain, their employers or families may find out that they are serving time.
This extreme vulnerability and fear of being exposed as “criminal” has made women unable to advocate for themselves and scared to contact services like the Ombudsman or justice advocates even when they are “free” during the week, and so the conditions have persisted. And because the women are serving on weekends, they have little or no access to what advocacy services there are inside the jail.
Editor’s note: We’ve asked the Justice Department for comment, and will update this post when they reply.
An inmate has died at the Southeast Regional Correctional Centre in Shediac, N.B.
The 49-year-old man was found unresponsive in his cell on Thursday night.
The Department of Justice and Public Safety says staff called 911 and tried to revive the man, but he died at 6:35 p.m.
“Efforts on behalf of correctional officers and medical staff to apply first aid, including the use of an automated external defibrillator (AED), were unsuccessful,” the department said in a statement.
Coroner Services and the RCMP were notified of the death and will be investigating. As well, Correctional Services Canada will launch an internal review.
The department says they will release the man’s name once next of kin are notified.
In New Brunswick, as in Nova Scotia, there is no requirement for a public inquiry following a death in custody.
A CBC News investigation has found that 13 people have died inside [New Brunswick] provincial jails since 2004 but only four cases have been subject to a public coroner’s inquest.
Details about the remaining nine cases remain largely secret.
The provincial government has agreed to start telling the public when an inmate dies in jail.
But the Department of Public Safety won’t apply its new policy retroactively to provide details about the 13 deaths.
In the death of Matthew Hines in Dorchester Penitentiary in 2015, officers who beat and then pepper sprayed Hines repeatedly in the shower while he begged for his life cleaned up bloodstains from the scene, and claimed they found Hines in distress. Staff filed false reports, and lied to Hines’ family. As Donkin reports, the guards involved were not disciplined until 15 months after Hines’ death. Two officers have since been charged with manslaughter and criminal negligence.
One day before the fire, the province’s ombud emailed the deputy minister of justice and public safety to raise alarm bells about rising tension at the Shediac jail between inmates in general population and protective custody.
Charles Murray’s office saw a spike in the “volume and nature” of calls with complaints about the jail. The ombudsman is responsible for investigating complaints for provincial inmates.
“None of our investigators (some of whom have been with us 20+ years) can recall anything comparable,” Murray wrote in an email to deputy minister Mike Comeau on Oct. 24.
Employees were doing their best, Murray wrote, but the tension level wasn’t coming down.
Ironically, the jail fire may have helped defuse some of the tension.
The unit that remains out of order housed maximum security inmates, who have all been moved to other jails, Murray said in an interview Friday.
He also believes the fire improved relationships between staff and inmates, who had to work together to escape the fire.
So we have a death in a jail where employees have recently been revealed to have been violating policy and bringing contraband to the facility, at a time where there were prior concerns about the likelihood of a major incident and an