 five and eight months of age, the T-lymphocytes in its immune system start attacking the insulin-producing beta cells in its pancreas. In humans, this process also occurs, but it’s gradual and can take a few years, so that type 1 diabetes is diagnosed in infancy or early adolescence,” Passos said.
The T-lymphocytes produced by the immune system of the NOD mice were isolated in the different stages of development, first in the thymus, then in the spleen and finally in the pancreas.
Using a functional genomics technique called a microarray, the researchers performed a complete study of T-lymphocyte gene expression in the NOD mice during each of these three stages.
In this study, the researchers identified messenger RNAs (mRNAs) and miRNAs in the animals’ T-lymphocytes. mRNAs convey DNA-encoded information from the cell nucleus to the cell cytoplasm, whereas miRNAs interact with mRNAs in the cytoplasm to prevent cells from producing proteins.
Using a bioinformatics tool to analyze the complete set of mRNAs and miRNAs, the researchers were able to identify which elements interacted during the evolution of T-lymphocytes.
“This is the first time a research group has demonstrated all the interactions between mRNAs and miRNAs in T-lymphocytes, from their development in the thymus through migration to the spleen to infiltration of the pancreas, in the context of type 1 diabetes,” Passos said.
The results of the analysis showed alteration of the expression of mRNAs that code for two proteins – Ccr7 and Cd247 (CD3 zeta) – in T-lymphocytes that attack the pancreas.
The researchers found that this alteration resulted from the action of a specific miRNA (miR-202-3p) and could lead to autoimmunity against the pancreas.
In his opinion, the study opens up prospects for the design of oligonucleotides – fragments of DNA or RNA – that could help to control type 1 diabetes.
Ataque autoimune das células beta pancreáticas causado por linfócitos T auto reativos/Divulgação.Brendan L. Loy is a top-rated attorney practicing in the Denver, Colorado area. Providing legal representation in Colorado for a variety of different issues, Brendan Loy was selected to Rising Stars for 2015, 2018 - 2019. He is admitted to practice before the courts in Colorado.
After completing undergraduate studies, Brendan L. Loy attended law school. Brendan Loy was enrolled at University of Notre Dame Law School. He earned a juris doctor degree in 2007. Brendan Loy would be admitted to the practice of law in 2008.
Brendan Loy represents clients with Appellate issues. Additional legal issues represented include Professional Liability: Defense, Employment Litigation: Defense and Civil Litigation: Defense.

CSS stand for Central Superior Services of Pakistan and every citizen having Pakistani nationality can apply for Civil Services Exams if he meets all the terms and conditions of the exams. Get CSS English Essay Notes for competitive exams consist of twelve papers in total including six compulsory and six optional papers. English is considered as one of the toughest papers in all the compulsory subjects that an applicant should pass to clear the civil services exams. It is the fact that most of the highly qualified and talented people can’t even pass the competitive English exams because it requires special techniques and knowledge to pass the exams.
What is English Subject Competitive Exam?
This consist of different sections and applicant has to pass all parts or sections of the English paper to qualify the exams. Course including comprehension, paragraph/expansion, and grammar and précis section. All the questions carry equal marks making total 200 for the CSS this paper.
English is imperative not only to qualify the exams but also to pass the viva and interview as well. English is part of official communication language, so it is important for the applicants to get hold of English as a language for effective communication in the office. It is one of the toughest papers to pass and most of the applicants unable to qualify for the exams due to their failure in the English paper.
Learning this subject as one of the subjects or getting a professional certification in written and spoken English helps applicants a lot in the Civil Service Exams. Writing flawless, creative and well-structured English is crucial to qualify the paper. Therefore, if you are planning to appear in the exams in the coming years, then you should take the class or get a professional degree that will help you to appear in the exams in the future. Though our education system is unable to deliver quality education that results in poor this subject, the low literacy rate in the country and lack of access to better education system result in an inadequate performance in the education sector, particularly in this subject. However, if you have any English degree, then it is entirely fine. There are many books, websites and tutors available that can help you to learn this subject over time.
This subject consists of multiple sections assessing writing, analytical and vocabulary of applicants through various questions. An applicant must have a good vocabulary, cram idioms, able to answer questions and they should also be able to write essay and comprehension answers. An applicant should be able to write flawlessly without grammar and spellings mistake to pass the paper. Essay, Précis, comprehension and a broad range of multiple choice questions must be cleared by the applicants to quality the paper.
English comprises of various branches, and each section assesses different skills of candidates.
The essay is the most important part of this subject, and it covers a broad range of topics. It doesn’t consist of any particular subject but rather include current affairs, national issues, social problems and a wide variety of topics for the CSS Exams. Most of the applicant also rely on the past papers for the exams and at the end they find it difficult to attempt the paper.
Practice makes the man perfect, so the same goes with précis and composition. The more you read, the better are the chances to attempt the comprehension in the CSS exams. The second part is paragraph/expansion, and there is a rule to complete this section of the exam which will discuss later.
There are lots of ways to prepare for the exams If you need online academic writing help, If you need online academic writing help, look at this CustomWritings.com – English essay writing service which hires real experts. First of all, the applicant should read books suggested by regulatory to cover most of the part. There are many websites to consult to prepare this course including the official forum of a competitive exam that offers lots of tips and tricks with material for the CSS aspirants. Consulting seniors, taking professional’s help and getting training from academies will help the CSS aspirants to pass the exams. Read daily newspaper, develop vocabulary and practice writing for the exams.
There is no key to success besides doing hard work and practice. So, if you want to pass the CSS exam and get qualified for the exams, use all the tips mentioned above.
EVERYONE LOVES AN UNDERDOG: Lessons from watching my first NBA Playoffs
If you haven’t been watching the NBA Playoffs, you have at least 1 more chance to watch history in the making!
I typically don’t watch basketball; but these past few weeks, I’ve been staying up way past my bedtime to watch these exciting games. I have been swept up in the fervor that is the Raptors vs. Warriors fight to the finish!
Admittedly, if the Raptors weren’t in the Playoffs, I probably wouldn’t be watching. I grew up just outside of Toronto and moved to the city for 5 years for school, so my Excited by Association feels are definitely at play; that “OMG I’m sorta kinda from there! This is MY TEAM, TOO!” feeling has got a hold on me.
But the other – and larger – factor that is making me absolutely PSYCHED to watch these teams duke it out is the love and support for the underdog team that is exuding from every corner of the North American continent right now.
The Limits of Raptor Fever Do Not Exist
I know some people reading this aren’t Raptors fans, but according to our Instagram poll, about 2/3 of our Synergee Athletes are cheering for the Raps. And according to this TSN article, most American fans are cheering right alongside the Canadian fans for the Raps.
But also, Toronto is a relatively new team that is rising to first-time heights in the NBA this year - which, Raptors fan or not, you gotta admit is pretty fricken cool!
The Raptors have shocked basketball fans across the nation. People are travelling across Canada and then lining up for DAYS to snag a spot outside – yes OUTSIDE! – the Scotiabank Arena and watch the game in “Jurassic Park”.
The Raptors unexpected, ground-breaking slew of wins has even resulted in McDonalds giving out an unprecedented over-two-million orders of free French fry across Ontario, amounting to $5.8 MILLION worth of fries to be given away! McDonalds signed a sponsorship deal to give away free fries in Ontario every time the Raptors made 12 three-point shots in a game. Unbeknownst to them, the Raptors would sink 12 or more three-pointers in over half their games this season, AND added another 5 during the playoffs. McDonalds was NOT expecting a) the Raptors to sink so many baskets, and b) Raptors fans to be such hungry fry fiends!
Everybody's Cheering for the Underdog
In short, the Raptors have been blowing peoples MINDS across the continent; and this team has been supported by an insanely excited and growing fan base throughout this season.