alling many things, including OnTime. Which installed fine (I just installed the 2009 version which I used previously) but after I installed its Customer Portal, it was not working properly: no matter which page I tried to view, it just redirected me to ErrorPage.aspx, which then further redirected me to itself in an infinite loop.
I thought I've seen this behavior before, but no matter what, I could not fix it. I tried everything. This included upgrading to the latest OnTime software version. Nothing. I changed the database authentication method to SQL authentication, creating an OnTime user. No luck. I messed around with every conceivable configuration setting of IIS. Didn't work. I can't even recall how many other things I tried. I also checked Axosoft's support site. The problem is mentioned there, but no real resolution is offered.
As I expected, the solution turned out to be banal. When you set up the Customer Portal, it tells you to locate your ontime.config file, right? Chances are that you locate this file in C:\Users\<your user name>\AppData\Roaming\Axosoft\OnTime Windows\10.0. Well... DON'T. Instead, copy this file to C:\inetpub\wwwroot\OnTime2010Portal (or wherever your Customer Portal is set up) before starting the Customer Portal configuration utility. If you are successful, it will create a web.config file in your Customer Portal folder and you're all set and ready to go.A patient was diagnosed with Cushing’s syndrome caused by a very rare cancer known as small cell carcinoma of the uvula — the small tissue that hangs at the back of the throat — in a case study that scientists think might be unique.
The study, “The First Report of Small Cell Cancer of the Uvula Presenting With Ectopic Adrenocorticotropic Hormone Syndrome,” was published in the World Journal of Oncology.
“To our knowledge, this is only the second case of [small cell carcinoma] of the uvula described in literature, and the first associated with any paraneoplastic syndrome,” the investigators wrote.
Paraneoplastic (meaning “associated with cancer”) Cushing’s syndrome, also known as ectopic Cushing’s syndrome, arises from the overproduction of adrenocorticotropic hormone (ACTH) by a malignant tumor outside the pituitary gland – most commonly, small cell lung cancer.
Small cell carcinomas are more common in older men, those in their 60s or 70s. Small cell carcinoma of the head and neck is extremely rare, with the most common site for such disease being the larynx, or voice box.
Moreover, there’s a relatively small number of articles reporting small cell carcinoma of the oropharynx — the part of the throat at the back of the mouth behind the oral cavity, which includes the uvula.
Investigators from the Advocate Illinois Masonic Medical Center, in Chicago, described the case of a 62-year-old woman with sore throat, difficulty swallowing, and nasal voice, who was admitted to the hospital with low potassium levels (hypokalemia).
The patient had been smoking since she was a child, plus had a history of alcohol abuse, high blood pressure and chronic obstructive pulmonary disease. She also complained of weight gain and generalized swelling. A brother was previously diagnosed with nasopharyngeal cancer, which affects the part of the throat connecting the back of the nose to the back of the mouth (the pharynx).
An examination revealed a uvular lesion and a computed tomography (CT) scan showed an abnormal mass in her throat with several enlarged lymph nodes, and the team suspected the same type of cancer as the brother.
“Biopsy of the lesion in the oropharynx revealed small cell cancer of the uvula … the patient was referred to the oncology clinic and on follow-up visit, she had shortness of breath and excess wheezing,” the scientists wrote.
Further physical examination and laboratory testing revealed an enlarged uvula, swollen legs, a high white blood cell count, low platelet count, and mildly elevated liver enzymes.
Imaging studies were suggestive of pneumonia, so the clinical team began treatment with azithromycin and ceftriaxone (both antibiotics), together with supplemental oxygen and bronchodilators to relieve her respiratory symptoms.
Magnetic resonance imaging (MRI) of the brain showed a mass in the lateral extension of the nasopharynx known as the fossa of Rosenmuller, which is consistent with small cell carcinoma of the uvula.
Researchers also noted thickening of the dura mater, the tough outer layer of tissue that covers and protects the brain and spinal cord, which led them to believe that the cancer might have spread.
Additional workup to determine the stage of the tumor revealed metastasis in the liver. While in the hospital, the woman had continuous high blood sugar and low potassium levels.
Such biochemical changes were suggestive of Cushing’s syndrome, since overproduction of ACTH leads to elevated cortisol levels, which in turn lowers potassium and raises blood sugar levels.
Blood testing showed high ACTH levels (479 pg/mL; normal range is -10-60 pg/mL), confirming ectopic Cushing’s syndrome due to excessive ACTH secretion by the small cell carcinoma of the uvula, the primary malignant mass revealed in the imaging scans.
“Patient was diagnosed with late metastatic small cell carcinoma of the uvula and she was determined to be a poor candidate for chemotherapy given worsening [low platelet count] and generally poor condition,” the investigators stated.
Tagged ACTH, case report, ectopic Cushing's syndrome, small cell cancer, uvula.
Share this Story: Cornwall seeking feedback on options for second water intake
Cornwall seeking feedback on options for second water intake
Handout/Cornwall Standard-Freeholder/Postmedia Network A diagram showing the location of the current intake and the path of the aqueduct leading to the purification plant.
The city is moving forward on work pertaining to a much-needed secondary water intake, beginning by seeking feedback from the public.
Cornwall seeking feedback on options for second water intake Back to video
“We are getting these comments from the public as a part of the Environmental Assessment process. We did have a public information centre scheduled for January that we needed to postpone due to pandemic restrictions. We are hoping to reschedule that,” said water purification plant supervisor Owen O’Keefe.
A public information centre will eventually be hosted by the city and the project consultant EBV Engineering. Residents will have the opportunity to attend a presentation, ask questions, and view display boards that highlight further project details.
Until the centre is rescheduled, residents can share their comments or concerns through the Engage with the City of Cornwall portal. The most-recent report from the environmental assessment process is also posted for residents to review.
“Some residents have been looking for information about where the new intake will be located and how it will be routed to the plant,” said O’Keefe.
City council first heard about the vulnerability of Cornwall’s current water intake system back in December 2019. Council authorized the process of seeking recommended options for a second intake in the summer of 2020.
The city’s only source of water is from a 65-year-old underwater intake that is part of the of Moses-Saunders Dam. If this intake were to become compromised, the result would be catastrophic, according to reports: Cornwall could be without water after about six hours, potentially impacting fire services, and more.
Second water intake could cost Cornwall $40 million
Potential for blockage threatens Cornwall's water supply
Assessment of options for Cornwall's second water intake begins
When asked if other nearby cities have experienced similar circumstances, O’Keefe explained that Cornwall’s situation is fairly isolated.
“We’re a little unique here with where our water plant is located on Second Street. A lot of facilities, when they are constructed, are located directly beside the source so that if anything were to happen they would be able to do a quick line…obviously we don’t have that luxury here; we are a ways away from our source of water.”
Council budgeted for an Environmental Assessment, and any supplementary assessments needed for project, in its 2022 budget. Funds for a condition assessment of the city’s current intake pipe wall was also requested. Overall, a new intake is estimated to cost the city around $40 million for a new pump intake, whether it be within the former Domtar site, or a second potential site on King Street.
“Right now, King Street is the preferred solution (due to cost projections). The next step would be completing a geotechnical investigation on the King Street location and seeing the results that come back, and if it looks favourable,” said O’Keefe, explaining the city would then look into land acquisition options.
Although the project was initially projected to take over five years, O’Keefe believes that 10 years is more realistic. At that time, Cornwall’s current raw water intake will have reached its lifespan of 75 years.
O’Keefe is hoping to have a location selected by the end of 2022.Security with remote start is what brought this customer in to our Northglenn location. After having his car broken into multiple times he decided it was a good time to invest in some kind of security to help keep people from trying to steal his car. At the time he decided he might as well take advantage of a combo and add Remote Start as well so that he could cool his car in the summer, and heat it up in the winter. He plans on coming back for some more alarm upgrades. He also wants to add a sound system now that he feels safe about it being in his vehicle. Come see us to get your