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- Assistant Store Manager buybuy Baby |.You've got this! I got sober on Oct 24 last year. Right before Halloween (I went to a boozy Halloween party on day 2! Wouldn't recommend it, but I can relate to what you're feeling right now) and only a month before the Holidays started. It was hard, but it made me more motivated with each holiday. Like, "im only x days sober, and I made it through a big drinking day without drinking! I feel amazing!"

 It helped me to keep telling myself "it's only a day. It doesn't mean I have to drink."What are the recent breakthroughs in physics in the fields of theoretical mechanics, optics & photics, meterials sciences, quantum mechanis, elecromagnetics, and statistical mechanis?
What counts as recent? Last 20 years or last 20 months?
May I suggest you subscribe the Physics News Update and find out for yourself?
A timeframe would be most helpful.
I would say that there's a lot of solid work going on in the fields of nonlinear dynamics and classical chaos.
Related Threads on What are the recent breakthroughs?
Finding out what are the recent problems!
Krumholz, Arie; Wang, Lidai; Yao, Junjie; Wang, Lihong V.
Characterization of tumor vasculature in mouse brain by USPIO contrast-enhanced MRI.
Gambarota, G.; Leenders, W.P.J.
Full Text Available Persistent fetal vasculature (PFV is a congenital developmental disorder manifesting as a fibrovascular remnant of the embryonal hyaloid vascular system within the vitreal space. Retinopathy of prematurity (ROP presents as varying degrees of non-vascularized retinal tissue with potentially devastating ocular complications. Both pathologies arise from ocular vascular system abnormalities, and various treatment modalities have been attempted in the past. In this report we describe a unique case of a late manifesting PFV that may be associated with the development of ROP, complicated by a visually significant cataract.
Leonard, A. S.; Lee, J.; Schubert, D.; Croen, L. A.; Fallin, M. D.; Newschaffer, C. J.; Walker, C. K.; Salafia, C. M.; Morgan, S. P.; Vvedensky, D. D.
The networks of veins and arteries on the chorionic plate of the human placenta are analyzed in terms of Voronoi cells derived from these networks. Two groups of placentas from the United States are studied: a population cohort with no prescreening, and a cohort from newborns with an elevated risk of developing autistic spectrum disorder. Scaled distributions of the Voronoi cell areas in the two cohorts collapse onto a single distribution, indicating common mechanisms for the formation of the complete vasculatures, but which have different levels of activity in the two cohorts.
Three-dimensional stereotactic atlas of the extracranial vasculature correlated with the intracranial vasculature, cranial nerves, skull and muscles.
Our objective was to construct a 3D, interactive, and reference atlas of the extracranial vasculature spatially correlated with the intracranial blood vessels, cranial nerves, skull, glands, and head muscles.The atlas has been constructed from multiple 3T and 7T magnetic resonance angiogram (MRA) brain scans, and 3T phase contrast and inflow MRA neck scans of the same specimen in the following steps: vessel extraction from the scans, building 3D tubular models of the vessels, spatial registration of the extra- and intracranial vessels, vessel editing, vessel naming and color-coding, vessel simplification, and atlas validation.This new atlas contains 48 names of the extracranial vessels (25 arterial and 23 venous) and it has been integrated with the existing brain atlas.The atlas is valuable for medical students and residents to easily get familiarized with the extracranial vasculature with a few clicks; is useful for educators to prepare teaching materials; and potentially can serve as a reference in the diagnosis of vascular disease and treatment, including craniomaxillofacial surgeries and radiologic interventions of the face and neck. Â© The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Radiologic Assessment of Native Renal Vasculature: A Multimodality Review.
Development of collagen fibers and vasculature of the fetal TMJ.
Using 12 human fetuses, histological development and changes in connective fiber structure and fine vascular patterns have been investigated in various fetal gestational stages by light and scanning electron microscopy. The main arterial supply of the articular disc was from the bilaminar region and pterygoideus lateralis muscle. The vascular network on the disc surface was related with fluid secretion. When the bilaminar region was compressed, it caused ischemia and fibrosis as the main pathological changes in TMJ derangement. A decrease in fluid from blood vessels might occur in TMJ degeneration. Collagen fibers in the disc passed mainly anteroposteriorly. In the anterior and posterior bands, muscular tendon fibers came from the pterygoideus lateralis muscle and superior stratum of the bilaminar region. In the posterior band three-dimensional structures of collagen fibers suitable for load bearing were observed. The compass network and process on the disc showed the normal structure that is formed gradually and has functions including dispersion, pressure bearing, friction-proofing and storage of the synovial fluid. Attachments of the disc were suitable for disc function. Large elastic fibers in the posterolateral part of the superior stratum of the bilaminar region may be antagonistic to the upper head of the pterygoideus lateralis muscle fibers passing medioanteriorly, indicating that this antagonism is available for disc function.
The effect of defibrotide on thromboembolism in the pulmonary vasculature of mice and rabbits and in the cerebral vasculature of rabbits.
Paul, W.; Gresele, P.; Momi, S.; Bianchi, G.; Page, C. P.
Cancer cells remodel themselves and vasculature to overcome the endothelial barrier.
Metastasis refers to the spread of cancer cells from a primary tumor to distant organs mostly via the bloodstream. During the metastatic process, cancer cells invade blood vessels to enter circulation, and later exit the vasculature at a distant site. Endothelial cells that line blood vessels normally serve as a barrier to the movement of cells into or out of the blood. It is thus critical to understand how metastatic cancer cells overcome the endothelial barrier. Epithelial cancer cells acquire increased motility and invasiveness through epithelial-to-mesenchymal transition (EMT), which enables them to move toward vasculature. Cancer cells also express a variety of adhesion molecules that allow them to attach to vascular endothelium. Finally, cancer cells secrete or induce growth factors and cytokines to actively prompt vascular hyperpermeability that compromises endothelial barrier function and facilitates transmigration of cancer cells through the vascular wall. Elucidation of the mechanisms underlying metastatic dissemination may help develop new anti-metastasis therapeutics. Copyright Â© 2014 Elsevier Ireland Ltd. All rights reserved.
Maternal separation diminishes Î±-adrenergic receptor density and function in renal vasculature from male Wistar-Kyoto rats.
Adult rats exposed to maternal separation (MatSep) are normotensive but display lower glomerular filtration rate and increased renal neuroadrenergic drive. The aim of this study was to determine the renal Î±-adrenergic receptor density and the renal vascular responsiveness to adrenergic stimulation in male rats exposed to MatSep. In addition, baroreflex sensitivity was assessed to determine a component of neural control of the vasculature. Using tissue collected from 4-mo-old MatSep and control rats, Î± 1 -adrenergic receptors (Î± 1 -ARs) were measured in renal cortex and isolated renal vasculature using receptor binding assay, and the Î±-AR subtype gene expression was determined by RT-PCR. Renal cortical Î± 1 -AR density was similar between MatSep and control tissues (B max = 44 Â± 1 vs. 42 Â± 2 fmol/mg protein, respectively); however, MatSep reduced Î± 1 -AR density in renal vasculature (B max = 47 Â± 4 vs. 62 Â± 4 fmol/mg protein, P adrenergic receptor expression and function in the renal vasculature could develop secondary to MatSep-induced overactivation of the renal neuroadrenergic tone. Copyright Â© 2017 the American Physiological Society.
A novel NDP mutation in an infant with unilateral persistent fetal vasculature and retinal vasculopathy.
Mutations in the Norrie Disease gene, Norrie Disease Pseudoglioma (NDP) lead to a phenotypically heterogeneous group of retinopathies. We report a novel mutation in the NDP gene identified in a patient whose clinical presentation was suggestive of unilateral persistent fetal vasculature (PFV). Ophthalmic examinations, ocular ultrasounds and sequence analysis of the exons of the NDP gene on peripheral blood DNA were performed. A four-month-old boy was referred to our institution for presumed unilateral retinoblastoma. The clinical and ultrasonographic exams were consistent with PFV and retinal detachment of the left eye as well as retinal fibrovascular changes in the right eye. A vitrectomy of the left eye revealed the absence of a retrolenticular stalk and mutation analysis of the NDP gene of the proband and mother demonstrated a novel missense mutation at codon 66, designated as