B1, ABCB1, and ABCG2 mRNA in liver tissue from a previously performed clinical trial in 29 patients randomized to treatment with placebo, 80 mg/day of atorvastatin, or 20 mg/day of fluvastatin for 4 weeks were measured using quantitative polymerase chain reaction. Treatment with atorvastatin (n = 10), but not with fluvastatin (n = 10), resulted in 3-fold higher expression of SLCO2B1 compared with placebo-treated patients (n = 9) (P < 0.05). Atorvastatin increased the expression of both ABCB1 and ABCG2 by more than 2-fold (P < 0.05). No difference was found in CYP2C9, CYP3A4, or SLCO1B1 mRNA expression in patients administered statins or those administered placebo. Premenopausal women (n = 8) had higher expression of CYP3A4 (P < 0.05) and lower expression of CYP2C9 (P < 0.05) compared with postmenopausal women (n = 10) and men (n = 11), respectively. Here we show for the first time that atorvastatin treatment leads to increased expression of the membrane transporters SLCO2B1, ABCB1, and ABCG2 in human liver tissue, which potentially may counteract the efficacy of the treatment, and our findings may cast light on the mechanisms of clinical problems with adverse reactions and drug interactions in statin treatment.Good evening all…. hope your week has been great for ya!! A little update here… Matthew is doing good today. Thank God.
On Tuesday, he went to the pediatrician and got his 6 month immunizations. That was no fun..for either of us. He got his head measured for a helmet. But looking at his head shape…I think daddy and I have been doing a good job of “shaping” it ourselves. lol… we literally rotate the poor kid like he’s rotisserie chicken haha… I have heard and read that having a helmet for a couple months or even weeks is hard on a kid.. so I am not really looking forward to it.. we shall see.
On Wednesday, Feb 3rd, we woke up before sunrise and headed to Loma Linda for weekly labs. Right after labs he went to his physical therapy session. The meeting went a lot better than I imagined. I had a vision of back flips and rolls and such… but in reality… it wasn’t like that. lol.. she did some good stretches and showed us some exercises we can do for him at home. his stiff neck is not as bad as it was a few months ago. he can practically look behind him when looking right…but looking left he can only get to his shoulders. we are hoping with what we learned, he will soon have full range of motion in his neck.
we have to work a little harder on tummy time. its just so hard with only an hour between feedings… he’s so full at the end of a feeding…then I only have a little bit of time before the next one starts… its all about time management.
**he was absolutely NOT happy today!
I really hope one day we can get to a normal range… I have seen so many babys on like 9 hrs.. 10 hrs… frustrating to see other babys do so well.. but my husband always reminds me that Matthew has always been that special boy! our miracle boy. and so with that.. I am grateful..i am happy… I am blessed!!!
….Today was one of those days for me… I read about a few people that I follow about their children.. some not doing so well… one that passed away this morning. I can only imagine the pain they, as parents, are feeling. It brought back so many fears and emotions for me. It was a tough morning. Just one of them days, I guess.
Well… baby twin Callia is crying.. so I gotta go now..haha.. I will update some more soon. thank you all for your continued prayers. love you guys!!
I was taught basic cooking techniques by my master. However, I prepare ise ebi my own way and give it my own personal interpretation. I use five different cooking methods to prepare it. I serve it roasted, stewed, soaked in oil, steamed or grilled, and then I add five different types of aroma – sea urchins, citrus and lemongrass, plums, caviar with coral vinaigrette, Kombu seaweed and soy, which I combine and serve to the guest’s taste.
I have loved prawns since I was a child. When I was 13, I had an unforgettable experience when I tasted ise ebi for the first time. It’s a wonderfully tender spiny lobster with a rich umami flavor. Since then, I have used it as a major central ingredient and themed dishes around it. I buy mine from Ise, in Mie Prefecture. In Japanese cooking, ise ebi (spiny lobster) is more popular than lobster, which tends to be used more frequently in Western countries.MINI SHOP
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But, as with any statistic, you can make them say anything you want.
The Kings will face the San Jose Sharks in Game 7 of the Western Conference semifinals at Staples Center on Tuesday and things do look bleak. They have lost their last two Game 7s (both to the Colorado Avalanche) by a combined score of 9-1.
So the Kings don’t stand a chance.
On the other hand, the Kings are undefeated against California teams in Game 7s.
The Kings overcame a 3-2 series deficit against the now-defunct Oakland Seals in 1969, forcing a Game 7 on Bill “Cowboy” Flett’s third-period goal in a 4-3 victory in Game 6.
In Game 7 against the Seals, Ted Irvine scored two first-period goals, but it was third-period goals by Flett and Lowell MacDonald that pushed the Kings into the second round.
So San Jose doesn’t stand a chance.
ALSO:
Kings fall to Sharks, 2-1, to force a Game 7
It's all on the line for Kings after Game 6 loss to Sharks
Kings' Jarret Stoll says he feels good, has no timetable for returnOur Christian Education Ministry expands beyond the borders of merely teaching Sunday school on Sunday morning. We are an all-inclusive ministry that is dedicated to the cultivating of an environment of learning that motivates/encourages/provokes the lost to respond to the invitation of Christ to discipleship. Furthermore, we are committed to teaching sound biblical truths based primarily on the doctrine of the Father, Son, and Holy Ghost through a host of vehicles e.g., Sunday Bible Study, Thursday night Bible class, newsletters, and other ministering materials (for adults and children).
Our teachers are well trained leaders who are continually being equipped to meet the needs (spiritual, physical, financial) of our congregation and community through a number of practicum’s such as, Leaders Summits, Worders Workshop, conferences, etc. (hosted by Maranatha and its sister churches).Sorry as well.  

Mhmm. As I look at it, we've all experienced something. But many, just don't feel as comfortable, to talk about it. So they don't, and focus on other things. She had also posted other pics, between the two subs. But I could see that, even with some of the positive commentary, from the positive sub. Could see the more pics she was posting to the other, was starting to set up, a bit more of a reward system for her. Like she would get bolder in saying stuff back with the guys and vice versa. And I guess, it was really tapping into, her need to be seen as something, if not someone.

And for the woman I was speaking of, for some of her pictures, she did get feedback. But it was one, where she was doing a look back, over her shoulder pose. Trying to be a little sexy. And not a single up vote. Which come to think of it, I probably should have did my part, and said something nice. Just at the time, I didn't know if I could say anything, in a group, I wasn't a part of. But yea, to see the nothing response from one group, to another. Just still really blows my mind. 

Exactly. We are all made different, so we can learn something from one another. Share in this human experience, and grow. Not be just like the next person, on a physical level. But on a deeper one. I'm sorry to hear your family felt they had to change themselves, to fit in. Tragically assimilation, is always going to be part of our society. But I'm here for celebrating cultural differences.

It could very well be, a self hatred thing. Heck, there is so much of that going on as well. People being colorists and finding false status, in being with those they think are better, etc. It really would be something for this to be discussed. Kind