 CPU.

\-experience, fun project.

**Temperature** (during furmark + prime95 26.6 non avx):

GPU 62 C, fans at 1900RPM, Memory 96-100C - dropped about 6-7C with this mod from core, 10-12 from memory.

CPU 65 C, fans at 700 RPM - dropped 6-10C with this mod

Intakes are 900 RPM (3 A14s + F12)

Exhaust 700 RPM (1 A14 + S12A)Protein folding research stalled for decades because conventional experiments indicated that proteins fold slowly and in single strokes, whereas theory predicted a complex interplay between dynamics and energetics resulting in myriad microscopic pathways. Ultrafast kinetic methods turned the field upside down by providing the means to probe fundamental aspects of folding, test theoretical predictions and benchmark simulations. Accordingly, experimentalists could measure the timescales for all relevant folding motions, determine the folding speed limit and confirm that folding barriers are entropic bottlenecks. Moreover, a catalogue of proteins that fold extremely fast (microseconds) could be identified. Such fast-folding proteins cross shallow free energy barriers or fold downhill, and thus unfold with minimal co-operativity (gradually). A new generation of thermodynamic methods has exploited this property to map folding landscapes, interaction networks and mechanisms at nearly atomic resolution. In parallel, modern molecular dynamics simulations have finally reached the timescales required to watch fast-folding proteins fold and unfold in silico. All of these findings have buttressed the fundamentals of protein folding predicted by theory, and are now offering the first glimpses at the underlying mechanisms. Fast folding appears to also have functional implications as recent results connect downhill folding with intrinsically disordered proteins, their complex binding modes and ability to moonlight. These connections suggest that the coupling between downhill (un)folding and binding enables such protein domains to operate analogically as conformational rheostats.
Notem na figura de enovelamento de proteínas o formato da Estrela de Davi.OUR Rumanian party celebrated on May 18 the 40th anniversary of the revolutionary activity of its founder and ideological inspiration comrade Gherea. The Russian septuagenarian revolutionary “stopped off” in Rumania on the eve of the Russo-Turkish War and after only a few years this compatriot of ours had under the name of Gherea won a huge influence among first the Rumanian intelligentsia and then among the advanced workers. Literary criticism from a social standpoint was the main sphere in which Gherea, a writer by the “grace of God”, had developed the consciousness of the advanced groups of Rumanian intellectuals. From questions of ethics and personal morality he developed to scientific socialism. To be sure the epoch of intellectual socialism ended in Rumania with a more abrupt crash than anywhere else. Among Rumanian ministers, diplomats and prefects there can be found not a few of those who learnt the alphabet of political thinking from Gherea. Fortunately they are not the only ones. Since the 1890s Gherea took the first generation of Rumanian socialist workers through the school of Marxism. Along with Gherea and Rakovsky they were becoming during the period of the Russian revolution the initiators of a new workers’ socialist party.
In 1908 after the stormy uprising of the Rumanian peasants, Gherea published his book Neo-Serfdom, the chief work of his life.
All the contradictions of the social and political life of Rumania: the bondage of the peasants, judicially repealed but resurrected by the logic of economic relations; the parliamentary regime set up on the basis of Asiatic agrarianism; “British” freedoms in the cities, the old-style Turkish despotism in the countryside – all these phenomena are subjected in Gherea’s great book to a truly masterly analysis where clarity and simplicity go hand in hand with a genuine Marxist profundity. A translation of this book would be a valuable contribution to the literature of Russian socialism.
In the time of the Balkan War as now, Gherea carried on and will carry on an irreconcilable struggle against the expansionism of Rumanian imperialism and for the All Balkan Democratic Federation. He forged and sharpened the weapon with which the Rumanian workers have fought and are fighting against the patriotic schemers and poisoners. With his clear and calm penetrating mind he will remain an indispensable theoretical adviser to the Rumanian proletariat. While shaking the hand of our senior friend we warmly wish him strength and good health for the struggles to come. We shall not speak of enthusiasm and confidence in the future as there are ample of these qualities in Gherea.
Nashe Slovo, No.100, May 29, 1915
Last updated on: 10.4.2007Plethora’s automated factory now offers CNC milling and turning in 23 materials, including aluminum and copper alloys, plastics, steels and stainless steels. Their machining services support 3-axis and 5-axis-indexed machining, accommodating approach vectors for complex geometry from any angle.
“The hand built, enormously accurate Matsuura MX-520 is an exceptional choice for such a groundbreaking company as Plethora. We are honored to be a part of their revolutionary business model where they inspire customers who need fast, reliable, precision parts production,” said a Matsuura Machinery USA, Inc. Spokesperson.
With high-precision, performance, speed, accuracy and reliability, the MX-520 provides flexibility and versatility allowing full 5-axis functionality without multiple setups.
“With the addition of the Matsuura MX-520 and CAMplete software we have been able to run multiple parts at a time with simultaneous 5 axis toolpaths and have the confidence to run the programs without collisions,” said von Sothen.
“This increases our productivity by keeping the doors shut and the spindle running for longer periods of time,” von Sothen added.
The MX-520 5-Axis Vertical Machining is one of the most sought-after machining centers having all the expected qualities and features of a Matsuura machine, but with a very competitive price tag.
Plethora’s local Matsuura Machinery USA Distributor is Selway Machine Tool. Selway Machine Tool is the exclusive distributor of Matsuura products on the West Coast, offering a wide variety of manufacturing solutions including: machine tools, accessories, automation, service and application support.
Plethora has been exceptionally pleased with Selway Machine Tools.
“We purchased the Matsuura MX-520 from Selway and their applications engineers came on site for hands-on training with the machine and CAMplete software. The training covered everything we needed to get up and running customer parts on the first day with confidence, and all of the questions and roadblocks I’ve encountered since then have been addressed with urgency by Selway’s application engineers,” von Sothen explained.
Plethora machined joints for prosthetic legs for amputee athletes on the Matsuura MX-520. The components may be seen at the end of this post.
Plethora’s software is the first of its kind to provide instant feedback and connect users directly to a factory. The CAD add-in works directly within Autodesk Inventor, SolidWorks and NX and as a web-app platform giving instant pricing and manufacturing feedback to anyone with a CAD model. Plethora’s custom automation software automatically converts 3D files and specs into the code needed to machine the parts inside the company’s state of the art factory. Plethora controls every step of the process to guarantee that the customer’s parts are machined to their exact specifications and shipped on-time.
“We start with the design software: our CAD Add-in analyzes your model for manufacturability and price. This avoids the usual back-and-forth of quoting and feedback – letting you focus on making parts, not managing your suppliers,” said Plethora’s Product Line Manager, Natalie Klapper.
After the order is placed, the customer’s design files enter the Plethora Production System where their automated software converts them into the instructions the factory uses to produce and inspect the part. The company is committed to a “full stack” approach, considering it is the only way to truly transform the production process into an on-demand system of creation.
Transparency and quality customer service are important to Plethora and their processes keep customers up-to-date on the progress of their parts.
Plethora founders Jeremy Herrman, 30, and Nick Pinkston, 33, met in 2008 when they bonded of a shared love of tinkering and a mutual fascination with the 3D printing industry. The two heard the same complaint repeatedly: it was challenging for hardware entrepreneurs to find manufacturers willing to take on their projects.
In 2014, the two launched Plethora – a fully vertically integrated factory in the Dogpatch neighborhood of San Francisco, which they filled with advanced 3D printers, robots and traditional milling machines.
According to Hermann, he believes the industry has not changed much in 100 years.
“I feel like that visceral sense of holding what you build in your hand is a very strong emotion,” Hermann explained.
Plethora’s vision has brought in funding from Google Ventures, Founders Fund and others that hope to change the way manufacturing is done.
Learn more about Plethora at: plethora.com.
“At Matsuura, we understand quality customer service. The late Toshio Matsuura founded Matsuura Machinery in 1935 and his philosophy was simple: ‘Our entire company is a showroom.’ We maintain