R1AT) and ABA response element (DRE2COREZMRAB17) are enriched in promoters of BR biosynthesis associated genes. BR response element (CGTG[T/C]G) is present in promoters of CK biosynthesis associated genes. Tsuda et al., 2009). Cross-talk between SA and JA is proposed to play a role in fine-tuning of plant defense response (Pieterse et al., 2012). In a study expression of thirteen OPR (12-oxophytodienoic acid reductase-enzyme that converts linolenic acid to jasmonic acid) isogenes was monitored under different stress conditions. It was found that OPR1, OPR2, OPR10, and OPR13 in rice were induced by SA (Jang et al., 2009). SA may regulate JA biosynthesis through intermediaries i.e., NPR1 or directly.
NPR1 is known to play an important role in SA-JA antagonism, NPR1 is required for functional salicylate signaling in Arabidopsis-Pseudomonas syringae pathosystem. When NPR1 is impaired through a mutation, it resulted in enhanced expression of LOX2, an important enzyme in JA biosynthesis (Spoel et al., 2003). We also found NPR1 to be up-regulated (fold change = 2.949) under blast infection. NPR1 is known to regulate expression of genes by enhancing DNA binding of TGA transcription factors (Després et al., 2003). We did find TGA binding CRE (ASF1MOTIFCAMV) in promoters of both SA and JA HB loci but TGA expression was not up-regulated under present condition. Thus, SA through NPR1 facilitated TGA binding to ASF1MOTIFCAMV may regulate SA and JA biosynthesis. However, either this does not require up-regulation of TGA or the time point, experimental conditions and data analysis strategy used for this study were inadequate to capture expression of TGA.
JA HB genes LOX and four OPR were found to be upregulated but none of them had any SA-responsive CRE in their promoters. Similarly out of three only one SA HB gene Os04g43800.1 contained one JA responsive CRE (T/GBOXATPIN2). Os04g43800.1 is a phenylalanine ammonialyase which is also associated with secondary metabolite phenylpropanoid derivative synthesis. Analysis of CRE in upregulated JA and SA HB genes under both drought and blast revealed no CRE (except one JA responsive CRE in SA loci) that can be tied to SA or JA response directly, so it is highly unlikely that these hormones directly affect each-other's biosynthesis.

CONCLUSION
Our investigations into CRE-mediated regulation of differentially up-regulated hormone biosynthesis associated loci under blast infection and drought stress revealed that hormone biosynthesis pathways are subjected to hormone cross-talk. Plant response to blast and drought is associated with transcriptional modulation of biosynthesis genes of several hormones and these hormones modulate bio-availability of each other through a complex regulatory network. Abscisic acid and Brassinosteroid regulates Cytokinin by modulating its conjugation. Conversely Brassinosteroid biosynthesis is effected by both Abscisic acid and Cytokinin. Through our analysis we found that DREB transcription factors may be important in modulation of both Jasmonic acid and Ethylene biosynthesis. Moreover we found that though DREB response are known to be ABA independent but at least DREB2A response may be regulated by ABA signaling through C2H2 zinc finger protein transcription factors. Interestingly we found no indication of direct interaction of Jasmonic acid or Salicylic acid with each other's biosynthesis pathways. Thus, multiple hormones may modulate several hormone biosynthesis pathways through a complex regulatory networks, where biosynthesis of one hormone is effected by several other contributing hormones.

AUTHOR CONTRIBUTIONS
AD, RG, and SK conceived the idea and designed the study. AD and RG collected the data. AD developed and executed computational pipelines and took part in result analysis. RG performed literature survey and result analysis. AD and RG wrote the manuscript. SK edited the manuscript and supervised the study. AD and RG contributed equally to this study. All authors read and approved the manuscript.

ACKNOWLEDGMENTS
AD acknowledges UGC (RFSMS), Government of India, for financial assistance. RG acknowledges Center of Excellence in Systems Biology and Biomedical Engineering for financial assistance. This work is supported by Center of Excellence in Systems Biology and Biomedical Engineering, University of Calcutta.

SUPPLEMENTARY MATERIAL
The Supplementary Material for this article can be found online at: http://journal.frontiersin.org/article/10.3389/fpls.2016. 01303 Table S1 | List of hormone biosynthesis associated loci with fold change > 2 and adjusted p-value < 0.05 for Magnaporthe oryzae infection and drought stress in rice leaves.  (B) Cliques of CREs associated with hormone biosynthesis genes up-regulated under drought stress. Horizontal axis represents the cliques and vertical axis represents number of loci a particular clique is associated with. Loci belonging to different HB pathways are represented by different colors. Hormone abbreviations: CK, cytokinin; SA, salicylic acid; JA, jasmonic acid; ET, ethylene; ABA, abscisic acid ; GA, gibberellic; BR, brassinosteroid.The ability of the liver to transport antigen-antibody complexes containing polymeric IgA was tested in a model system using the isolated perfused rat liver and soluble complexes formed between trinitrophenylated (TNP) antigens and MOPC 315, a polymeric mouse IgA protein with anti-TNP activity. A double-label strategy (125I and 131I) was used to separately follow antigen and antibody during isolation and transport by the isolated perfused liver. Complexes formed in antigen excess and isolated by gel filtration were added to the perfusate. The quantity of antigen or antibody transported was determined by counting the radioactivity in collected bile fractions. TNP-human albumin (TNP-HSA) complexed to polymeric IgA antibody was transported from blood to bile while the same antigen complexed to IgG antibody was not. The transport of IgA-(TNP-HSA) complexes was inhibited by preincubation with human secretory component (SC), which indicated that transport of such complexes proceeds though an SC-dependent mechanism previously described for uncomplexed polymeric IgA antibody. Complexes (m.w. congruent to 970,000) of trinitrophenylated bovine thyroglobulin (TNP-TG) and polymeric IgA were transported less well than IgA-(TNP-HSA) complexes (m.w. less than or equal to 460,000), even though both types of complexes bound SC. The possibility that the poor transport of IgA-(TNP-TG) complexes reflected a size restriction on hepatic transport from blood to bile is discussed.
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