.
damage signalling in low- and high-grade human gliomas, and analyze the sources of such endogenous genotoxic stress. Based on analyses of human glioblastoma multiforme (GBM) cell lines, normal astrocytes and clinical specimens from grade II astrocytomas (n=41) and grade IV GBM (n=60), we conclude...... that the DDR machinery is constitutively activated in gliomas, as documented by phosphorylated histone H2AX (gammaH2AX), activation of the ATM-Chk2-p53 pathway, 53BP1 foci and other markers. Oxidative DNA damage (8-oxoguanine) was high in some GBM cell lines and many GBM tumors, while it was low in normal...... brain and grade II astrocytomas, despite the degree of DDR activation was higher in grade II tumors. Markers indicative of ongoing DNA replication stress (Chk1 activation, Rad17 phosphorylation, replication protein A foci and single-stranded DNA) were present in GBM cells under high- or low...
Concern : that damn turf.
watching : Teddy and Williams!
Crazy prediction : Giants will score over 20 so Denver offense better score more.
care level : 5 on a scale of 10.
Supposedly Giants oline is awful. Broncos defense should feast.
My biggest concern is injuries to key players. This derailed last season from the very beginning.
I am looking forward to watching the defense. It has the players to be special. I just hope we are not being overly optimistic.
My crazy prediction is Teddy will have about 275 yards, 2 touchdowns, and 1 interception in a Broncos narrow win 23-20.
Must-win. Care Level: 10/10.
I expect a defensive struggle.
I'll say that the offense will take about 3-4 drives before they take off and start having good success. It will be a lot of running and short quick throws. I'll be in Gatlinburg over the weekend so I won't get to watch it more than likely.
Yes, I won’t get to watch the game where I live, either. I might have to search out a link to watch it.
Not sure how much of Surmur’s influence is still on the current Giants roster, but hopefully this helps his preparation of Teddy.
No significant worries, but a lackluster start could put us in a late dog fight. My guess is that we get our crap together early and win by 10.
That's what I would normally have to do. I'll take my laptop with me, but I just don't think I'll be back at the town house to watch it.
Interesting they picked TBW as captain. Nothing against him, but I would have expected it to be one of the veterans that have been on the team for awhile.
Yeah that does seem a little odd. Especially since he wasn't named the starter until two weeks before week 1. I guess they just want a QB to be a captain.
Could be. I guess it also shows a certain amount of respect he has earned from his teammates in such a short amount of time.
I am expecting that for the duration of 2021 season. Prove me wrong Teddy!
Crazy prediction : Giants rush game success will cause us all to panic about the defense.
my new liberal friend..."
IF Saquon plays, and he probably will play some, he'll be on a tight "pitch count."
Anybody know who his his backup is?
Yeah you do....
make his mama proud...
I'm not terribly worried about the Giants O-Line getting to the second level of anything.
He hurt his ankle in practice, played in the final preseason game a bit and I think are just letting him rest it. Seems like a minor tweak.March & 1003495030914
How often does the bug occur? Every time (100%)
Steps: How can we find the bug ourselves? Do party actions with multiple friends.
What do you expect to see? Friends show up to do action with my Sim.
Connection Type Wifi
Please select your region Europe
Country The Netherlands
Additional feedback Bubble blower: 'Blow bubbles with' Karaoke: 'Perform a duet with...' other Sim doesn't show up. Other actions work with singing. BBQ: 'Show off grill skills'
April 2019
April 2019
This just happened at a party i’m at, called a Sim to karaoke and they both just stood in place where they were before. Bubble blower worked with 3/4 sims.
April 2019
April 2019
Make your Sim talk to the child and then go to another room. The child might go out as well.
This usually works for me.
April - last edited April
This issue is not fixed. The karaoke machine is still the same, no Sims show up to sing.
I forgot to take a screenshot of the bubble blower but I canconfirm it is still the same. Two of three Sims show up for action.
The barbeque is still the same:
I also experienced the same issue with newly added items:Cruz Needles Trump in Tame GOP Debate
The Republican presidential hopefuls were on their best behavior at Thursday night's debate, with almost no insults, ad hominem attacks, mockery or commentary about candidate appendages.
Billionaire businessman Donald Trump and U.S. Sen. Ted Cruz at the GOP debate in Miami, Florida on March 10, 2016. CNN Screenshot
MIAMI — The Republican presidential hopefuls were on their best behavior at Thursday night's debate, with almost no insults, ad hominem attacks, mockery or commentary about candidate appendages.
Instead, the four remaining GOP contenders for the party nomination — U.S. Sen. Ted Cruz, Ohio Gov. John Kasich, Florida U.S. Sen. Marco Rubio and real estate magnate Donald Trump — tackled big issues and kept the discussion on immigration, trade and the Middle East.
"We're all in this together. We're going to come up with solutions," Trump said. "We're going to find the answers to things. And so, far I cannot believe how civil it's been up here."
The first half of the debate, and much of the closing, was primarily between Cruz and Trump, and offered a glimpse of the coming one-on-one fight between the two men that many in politics are anticipating.
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"Donald's right. There are only two of us up here that have a path to the nomination," Cruz said, acknowledging that expectation.
The debate took place ahead of the Tuesday's primaries, the first winner-take-all contests on the GOP primary schedule. The setting, Miami, meant that moderators focused also on Cuba and the flooding implications of global warming.
There will be 367 delegates at stake. Besides Florida, several other states and territories will host primary contests: Illinois, Missouri, North Carolina, Ohio and the Northern Mariana Islands.
Trump is widely blamed for the devolving tone in this cycle's debates. But without his mixture of testosterone and acid, the debate resembled the approaches of past cycles.
Even so, Cruz did needle Trump — but in a more subtle manner than in more recent debates.
When asked about recent physical attacks at Trump events, Cruz directed a stump speech line directly at Trump.
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"At Donald’s rallies recently, he’s taken to asking people in the crowd to raise their hand and pledge their support to him," he said. "I’ve got to say... I think that’s exactly backwards. This is a job interview. We are here pledging our support to you, not the other way around."
He also questioned Trump's grasp of foreign policy and repeatedly revisited Trump's past political donations to Democrats.
"When it comes to these deals, Cuba and Iran, they were negotiated by Hillary Clinton and John Kerry," he said. "There's a real difference between us. Donald supported Hillary Clinton and John Kerry."
On many occasions, Trump avoided returning fire and rather focused on explaining himself.
Rubio had one of his strongest nights, calmly countering many of Trump's most incendiary statements. But it is probably too late for the senator; his campaign's future rides on his performance in his home state on Tuesday, and there is little indication in recent polls that he will win there.
Cruz is scheduled to campaign Friday in Orlando..Welcome to the Canadian Phycological Culture Centre (CPCC), formerly known as the University of Toronto Culture Collection of Algae and Cyanobacteria (UTCC). Founded in 1987, the CPCC provides research quality cultures, culture medium, and other related services to educational institutions, government and commercial laboratories worldwide.
Housed at the University of Waterloo in the Department of Biology, the CPCC is internationally recognized as a major service collection of living freshwater algal, cyanobacterial and Lemna spp. (duckweed) cultures. Strains are often used for environmental research and biotechnology applications including:
- a potential source of biofuels and natural novel products
- carbon sequestration
- bioremediation
- bio-control and toxic effects of cyanobacteria
- toxin detection methods
- algal bloom studies
- ecotoxicity testing
- physiology and molecular basis of metal toxicity and tolerance in algae
- the impact of ultra-violet radiation on algae
- taxonomic identification of algae by DNA barcoding
- taste and odour problems in drinking water
- aesthetic landscaping (i.e., algae gardens)
Last updated: November 30,