ropharyngeal, and hypopharyngeal cancer patients were stained with PD-L1, PD-L2, PD-1, and CTLA-4 antibodies. Proportion of tumor-infiltr...
Head and neck squamous cell carcinoma in people living with HIV in France.
Association of TET3 epigenetic inactivation with head and neck cancer.
Authors: Misawa K, Imai A, Mochizuki D, Mima M, Endo S, Misawa Y, Kanazawa T, Mineta H Abstract The aim of this study was to clarify the epigenetic regulation of ten eleven translocation protein (TET) family genes, which can provide insights into the mechanisms of tumorigenesis and the risk of disease recurrence in head and neck squamous cell carcinoma (HNSCC). We generated methylation profiles of TET1, TET2 and TET3 genes in tumor samples obtained from 233 patients with HNSCC; these included 57 hypopharynx, 44 larynx, 69 oral cavity, and 63 oropharynx tumor samples. The mRNA expression and promoter DNA methylation...
Paprika Spanish De la Vera Smoked Hot by La Dalia has been milled with a blend of different types of Spanish peppers in order to give it an intensely smoky aroma, rust red color, and deep, mildly spicy flavor. Paprika Spanish De la Vera Smoked Hot by La Dalia tastes similar to smoked paprika, but the use of hand-harvested “ocáleas” and bola peppers that were smoked with encina oak wood for 15 days gives this paprika a uniquely Spanish feel. The peppers used for Paprika Spanish De la Vera Smoked Hot by La Dalia were grown around the Tietar River in La Vera, the ideal climate for their growth with mild temperatures and plentiful rain.
Suggested Applications: Paprika Spanish De la Vera Smoked Hot by La Dalia is an indispensable ingredient for many types of Spanish sausages including chorizo and lomo pork loin, and is perfect for adding and authentic flavor to paellas. Paprika Spanish De la Vera Smoked Hot by La Dalia is also used in American cuisine for seasoning barbecue pork, lamb stews, and kebabs.
Founded in 1913, La Dalia was the first company to produce the famous smoked paprika of LA Vera. La Dalia is a family owned company that has continued to produce the finest quality pimentón for generations by using traditional production methods and traditional tools, including stone mills. La Dalia produces Pimentón de La Vera that is Denominación de Origen (D.O.), ensuring its authenticity and quality.
<filename>src/index.tsx<gh_stars>0
export { default as Button } from './Button'
export { default as Portal } from './Portal'
The movie ” The Big Short “ is the big screen adaptation of the Michael Lewis’s book about the disturbing period of Great Recession of the year 2008 and some people who generated huge profits while the economy collapsed.
Michael Lewis earlier earned huge accolades for his previously written books – ‘Moneyball’ and ‘The Blind Side’. The Big Short is a story of eccentric traders who anticipated the US housing bubble and generated huge amount of profits out of it. It is a story of those fund managers and bankers who created rubbish securities backed by mortgages. The movie has beautiful ladies – Margot Robbie and Selena Gomez explaining about subprime loans and Collateralized Debt Obligations (security on a security). The story consists of eccentric traders and financial organizations betting blindly for the very selfish motive of making money.
The movie shows several investors betting blindly on housing market. Instead of being part of flock of sheep, they could have stopped and analyzed that something fishy was going on in the market. The bankers creating unnecessary derivatives, investors investing copiously without having any prior sane thoughts, mortgage companies coming up with risky securities and entering public markets with sky-rocketing valuations and the whole economy in a party hangover. Nobody cared about the after effects, or I would say, the side effects of all these practices. People kept on lending money, others kept on betting and so on and so forth. And when their hangover was finally over, they saw themselves in the most unfortunate pit of distressed economy.
The movie shows an exotic dancer claiming to own five houses in front of a hedge fund manager named Baum (played by Steve Carell) and Baum is left puzzled. An exotic dancer cannot be possessing five houses as her source of income is not regular. Just like her, several people bet their life stakes and availed subprime loans – loans that were offered at a rate above prime to individuals who do not qualify for the loans at prime rate due their credit history. Investors saw this as a golden chance of making huge amount of money and becoming rich without even thinking for twice that if it was that much easy to get rich, everyone would be.
Christian Bale plays a socially challenged computer geek fund manager while Steve Carell played a role of another fund manager. And both of them did a proper and thorough research on CDOs (Collaterised Debt Obligations) and subprime mortgages and came to a common conclusion that the economy was gonna collapse due to huge market crash. After all, its your money that you are investing. So, it is strongly advisable to go for a proper research of the securities and various investment products. Even if you don’t understand what you are actually investing in, it is strongly recommended that you should not invest. A proper know how of something is a must. Mere mouth publicity regarding something does not hold good. It is wisely said that, half knowledge about anything is dangerous, so without proper research, it’s a just a gamble.
It is brilliantly portrayed in the movie that even credit ratings agencies were paid by the banks for subprime loans. If one agency refuses to rate the products, banks simply take their business to other agency. In the movie, S&P rates those faulty loans AAA and that is something very foolish. Investors banked on credit rating agencies for making smart and effective investments. Hence, it is an very important lesson to learn that even rating agencies are a business to make money. Therefore, instead of trusting blindly on the products rated AAA or similar, one must check for the product history. And if the product is new to the market, one must show patience, sit back and analyze before making any investment.
It is the law of financial markets that what goes up must comes down. Prior to 2007-08, people of America were having world’s greatest party as they had access to huge sum of money, and if not money, they had mortgage backed securities and loans with very less and easy credentials to bank upon. The valuations of these bank products were sky-rocketing, even the exotic dancers claimed to have own five houses just because of the backing of subprime loans. But in the year 2007-08, it was a catastrophe in the US economy. Due to this, an estimated 8.7 million people lost their jobs, the stock market tanked and the Americans lost a total of about $1 trillion which was a huge blow to the US economy.
Try to be a market watchdog. Try not to trust your financial advisors and brokers blindly. Find out as much as about them – their experience, their license, their reputation and qualification. Learn to understand the market fundamentals and cultivate the ability to act prudential. After all, it’s your life savings that you are putting in.
<reponame>fanvyr/YappyGitLab<gh_stars>0
const EventResponse = require('../EventResponse');

class NoteIssue extends EventResponse {
  constructor(...args) {
    super(...args, {
      description: 'This event gets fired when someone comments on an issue',
    });
  }

  embed(data) {
    const comment = data.object_attributes;
    const issue = data.issue;
    return {
      color: 0x996633,
      title: `Commented on issue #${issue.iid}: \`${issue.title}\``,
      description: comment.note,
    };
  }

  text(data) {
    const actor = data.user.name;
    const comment = data.object_attributes;
    const issue = data.issue;
    return [
      `**${actor}** commented on issue **#${issue.iid}** _${issue.title}_`,
      `    ${comment.note.slice(0, 100).replace(/\n/g, '\n   ')}`,
      `${comment.url}`,
    ].join('\n');
  }
}

module.exports = NoteIssue;
Definition of "Abortion"
Induced abortion is the intentional killing of a fetus/embryo, by forcing it out of a womb before it is able to survive of its own.
Late termination of pregnancy (aka late-term abortion) is an induced abortion of a fetus that may be able to survive on its own.
Ethics aside, there's lots of reasons why mothers' might decide to abort a fetus. How is this done?
There are 2 ways. Using medications, or surgery. In the 1st trimester, medications are just as effective as surgery, and there's less complications, so we opt for that. In the 2nd trimester, we usually do surgery. We can either manually remove the child using a vacuum, or surgically scraping it out.
14 the third of three major theoretical treatment approaches, and treatment implications kathryn hall he prevalence of severely fibrotic corpora