 State University
    gradYear: '1998'
    degree: Doctorate of Veterinary Medicine
  title: Speaker of the House
  spouse name: Kelly
  number of children: '2'
  birth place: Gillette
  occupation: 'Rancher, Veterinarian '
  leadership:
  - startYear: '2021'
    endYear: '2022'
    position: 'Speaker of the House                              '
    currentLeader: true
  - startYear: '2019'
    endYear: '2020'
    position: House Majority Floor Leader
    currentLeader: false
  house years: 'House:  2013-Present'
  prior service:
  - chamber: House
    startYear: 2013
    endYear: Present
    district:'District 03, '
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According to a new study, reducing blood glucose levels can partially restore reproductive hormone levels in obese females, leading to enhanced fertility.
The findings suggest that a common type 2 diabetes medicine that lowers blood glucose levels can partially restore abnormal levels of reproductive hormones in a well-established mouse model of obesity. Many obese women who have fertility problems have changed amounts of reproductive hormones. There is currently no effective treatment for this.
The development of a medicine that not only improves women’s metabolic health but also addresses obesity-related infertility would be a big step forward, potentially improving the quality of life for many people.
Although fertility issues in obese women are well known, there is a lack of effective and tailored treatments to address them. Obesity is an increasing health problem, which means that more women are experiencing reproductive difficulties.
Obesity-related fertility concerns are complicated, but data suggests that they are linked in part to changes in energy metabolism, which lead to changed levels of reproductive hormones, which can subsequently disrupt the menstrual cycle and ovulation. Obese people are more likely to acquire type 2 diabetes, and they frequently have high blood glucose levels as well as other metabolic abnormalities.
The MC4R gene knock-out (KO) mouse is a well-studied obese model that also has irregular reproductive cycles and altered hormone levels, resulting in decreased fertility. Because the mouse reproductive cycle is similar to that of humans in terms of the profile of hormone level changes, but being much shorter in duration, the MC4R KO mouse provides an excellent, representative model for preliminary studies of metabolic and reproductive function in obesity.
Dapagliflozin is a medicine routinely used to treat type 2 diabetes, where it lowers blood glucose levels and improves other metabolic health markers, although its effects on reproductive health and fertility are unknown.
Professor Chen and colleagues from Australia’s University of Queensland evaluated the effects of dapagliflozin medication on metabolic health and reproductive hormone levels in the MC4R mouse model of obesity in this study. When compared to non-treated mice, blood glucose levels were normal after only 8 weeks of treatment, body weight was lowered, the reproductive cycle was normalised, and levels of reproductive hormones and ovulation were partially recovered.
The researchers plan to look into the molecular mechanisms implicated in the use of dapagliflozin to improve reproductive function, which could lead to better targets for future fertility treatments in women.
Mohenjo Daro, one of the greatest cities of the Indian Bronze Age, was a major city of the Indus Valley Civilization.
Located in present-day Pakistan, it was built in the 3rd millennium BC. JC and since its rediscovery in the 20th century AD, it has been one of the most important sources of information on this forgotten civilization of the Indus Valley.
A site full of treasures where many objects and artefacts have been found, as well as the writing of this civilization—one of the oldest writings in the world—which has still not been deciphered until now!
On the front of this t-shirt have been chosen and assembled three characters of this mysterious writing from the Indus Valley civilization.
One of the most complex and mysterious seals that have been found from this civilization.
Next time you’re caught in a thunderstorm and feel the urge to make out with someone, blame the movies. We can thank pop culture for molding certain romantic tropes, like kissing in the rain, leaping into a lover’s arms in airports, and associating fireworks with epic romance. Still, no act of passion is more iconic than a tryst on the sand or in the waves. Thanks to From Here to Eternity, many have attempted the clumsy, difficult, close-to-impossible act of sex on the beach.
Sex on the beach is one of those things that, at first, seems like a good idea. But when you consider free-range sand particles, aggressive waves, and potential arrest for public exposure, you start be thinking otherwise.
That said, if you’re still doggedly pursuing the idea of an eternal summer, look no further than these movie scenes for instructions on beachside passion. They’ll teach you the Hollywood ways of love better than anyone. Watch these movies, then head out to catch your wave.
BOSTON, Massachusetts (CNN) -- The operator of a Boston trolley that rear-ended another in May was indicted Wednesday on a charge of gross negligence, the Suffolk County district attorney said.
Passengers walk past firefighters at a Green Line station in Boston after the trolley collision in May.
Aiden Quinn, 24, has admitted to investigators he was text-messaging seconds before the collision, National Transportation Safety Board member Debbie Hersman told CNN in May.
According a news release from the office of District Attorney Daniel Conley, "as Quinn was texting, he ran through yellow and red warning lights at about 25 mph within the subway tunnel. Quinn's train then struck the two-car train ahead of him, which was stopped at another red light and had its brake lights on."
The collision knocked the stationary trolley cars about 36 feet down the track and caused more than $9 million in damage, officials said.
Sixty-two people were injured in the crash, the Massachusetts Bay Transportation Authority said.
If convicted, Quinn could be sentenced to up to three years in state prison and fined up to $5,000.
Quinn's attorney, Michelle Menken, argued the charge is excessive because the crime wasn't one of violence and there was no criminal intent.
"It doesn't seem appropriate to be charging Aiden Quinn criminally," she said.
Investigators for the transportation authority and the National Transportation Safety Board found that the brakes on Quinn's train were working properly and that there were no defects in the tunnel lights or tracks. They classified the cause of the collision as human error.
The crash happened at 7:18 p.m. May 8 as the Green Line trains were westbound between the Park Street and Government Center stations in downtown Boston.
CNN's Laura Batchelor contributed to this report.
All About U.S. National Transportation Safety Board • BostonScroll down to view highlights from the final week of our 30 Ways in 30 Days anniversary campaign including a Latinx cultural celebration led by our Women of Color Affinity Group, Mosaics and Mimosas service brunch, our first Learning and Development Day, and more!
LDDs are here & we’re excited to welcome our FIRST guest facilitator! Jessie Gerson, Co-Director of Write Boston will join us for one of our favorite trainings... If you build it they will come - ACMs will learn best practices for developing strong & resilient relationships with students. Develop a toolkit for dealing with difficult behaviors in the classroom!We did yesterday! We got to AK about 8:30 and headed straight to Pandora. There was a huge mob waiting to get in the actual section and then we all got moved in and pretty much everyone went to get in the FOP line. We officially got to the FOP line at like 8:40 and we started moving pretty quickly. We went through the full queue and pre show and ended up only waiting about an hour for the actual ride. I'd recommend it. I wasn't going to rope drop because I heard people get there at like 7:30 but it worked alright for us. :)Taylor Swift strikes again.
A fan said Wednesday that the “You Need to Calm Down” singer had performed another random act of kindness by giving her $3,000, approximately £2,524, to pay her rent during the coronavirus pandemic.
And she was one of several Swifties who shared similar stories.
really wishing i had taken a shower this afternoon instead of putting it off LOL— samantha (@manthapaige13) March 26, 2020
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