. Probiotics are popular for their role in different pathologies, mostly in the intestinal related ones. Their impact on gut microorganisms is crucial because they can positively (i.e., biodetoxification from mycotoxin, fungi, acrylamide, metals, virus, reduce pro-inflammatory responses, antimutagenic and anti-carcinogenic activities) and negatively (i.e., transfer of antibiotic resistance) modulate human health. Considering that consumers respond differently to probiotics according to age, genetic characteristics of gut bacteria, diet, antibiotic use, and environmental cues, precautions are necessary before their use, and for this reason, they should be recommended only by health care personnel/clinicians, while more concerns are in their market distribution.
The biodetoxification mechanisms of the action of probiotics belonging to Lactobacillus, Bifidobacterium, Saccharomyces, and other types of more or less popular genera (Bacillus, Enterococcus, Escherichia, Streptomyce, Pediococcus) are proved to be influenced by factors specific to (i) bacteria genus and strain; (ii) environmental dependent factors; and (iii) toxin dependent factors. Probiotics belonging to Lactobacillus are the most studied ones and are more correlated with the ability to bind toxins (mycotoxins, heavy metals, etc.) on the cell wall. Reactive functional groups and compounds present in the cell wall, such as proteins, peptidoglycan, and polysaccharides; 1,3-β-glucan for the yeast cell wall, are recognized to be responsible for probiotic binding capacity. The differences between the strains in relation to toxin absorption and binding are given probably due to the diversity in cell wall structures and bacterial cell membranes.
Other probiotic biodetoxification pathways are correlated with probiotic metabolites, co-cultivation of different probiotics or different probiotic/compound formulations (i.e., lactulose), gene expression, and sustaining fecal excretion.
Due to the fact that probiotics decrease toxin absorption and by reducing its toxicity, they are correlated with strong anti-carcinogenesis and anti-mutagenesis action.
Based on a thorough review of the capacity of probiotics to react with pathogens, fungi infection, mycotoxins, acrylamide toxicity, benzopyrene, and heavy metals, we conclude that specific probiotic strains and combinations offer significant health outcomes and positively impact in vitro and in vivo detoxification processes. Despite the fact that there are many publications on the biodetoxification properties of probiotics, their application in practice in the detoxification of food and/or feed has been narrow. To increase this utilization, we concluded that specific mechanism pathways should be elucidated, the toxicity of degradation products should be also studied, and there should be safety regulation on the use of probiotic strains towards food matrices and in vivo systems.

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