 and greenhouse gas emissions.
Wrap gifts in recycled or reused paper. Get creative and use alternative gift wrapping, such as reused paper bags and pine tree branches, old calendars, newspaper or posters.
Walk and bike when possible.
Upgrade to energy-efficient LED holiday lights and recycle any old strands of lights. HolidayLEDs.com accepts old holiday lights for recycling via their mail-in program.
Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells.

Neuronal cell specific cyclin-dependent kinase 5 (Cdk5) is a known regulator of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. We report that Cdk5 also plays an important role in the proliferation of breast cancer cells MCF-7 and MDA MB-231 and is functionally involved in chemosensitivity as well as in cell death pathways induced by anti-cancer drug carboplatin (Carb). Here, we demonstrate that carboplatin induced Cdk5 activation under positive regulation of ERK, promotes cell death in MCF-7 and MDA MB-231 cells. DNA-damage stress enhanced ERK activity utilizes Cdk5 as one of its downstream targets for the execution of death signal in carboplatin induced death in MCF-7 and MDA MB-231 cells. Additionally, present data clearly indicates that activated Cdk5 modulates p53 transactivation in MCF-7 cells. However, in p53 mutant MDA MB-231 cells, Cdk5 mediated cell death is likely to be p53 independent. Collectively, our findings not only draw attention to the extra-neuronal functions of Cdk5 but also propose Cdk5 as a novel and potential therapeutic target of chemotherapeutic drugs.Assessment of arm function in stroke patients: Rivermead Motor Assessment arm section revised with Rasch analysis

Objective : To investigate the construct validity and unidimensionality of the Rivermead Motor Assessment, arm section, using Rasch analysis which transforms the ordinal scale into an interval scale with hierarchical ordering of items. Setting : Twelve stroke units and rehabilitation centres across Belgium, Germany and Switzerland. Subjects : Two hundred fifty-two stroke patients, average (SD) age of 63.5 (13.22) years. Main measures : Principal component analysis on the Rasch data gave additional information on unidimensionality. Differential item functioning established the stability of items for gender, age, country, hemiplegic side, stroke type, and time since stroke. Results : Four items did not meet the requirements for the Rasch model and were removed. These were `Lying, protract shoulder with arm in elevation', `Pick up tennis ball from table, release on midthigh, return to table, release', `Same exercise with pencil' and `Pick up piece of paper from table. Release five times'. Principal component analysis of the remaining 11 items revealed two dimensions in the scale, `static and dynamic control of movement', and `coordination'. All items were stable among the subgroups of the sample. Conclusion : The Rivermead Motor Assessment, revised arm section meets the required criteria for validity and unidimensionality. It consists of 11 individual items, which yield two subtotals of overall upper limb ability of the patients. It is a valid tool to evaluate upper limb function after stroke.I will leave my old blogs on here, and start using this blog for personal musings about life, work, family, fatherhood, and anything else that comes to mind!
If that is of interest to you, great….if you are only interested in ‘occupiers journal’ commentary on corporate real estate, workplace design and management, facilities and such like, then do please follow the OJL team at:
Thanks & regards,
Paul
paul.carder@occupiersjournal.com
Twitter: @occupiers … @paulcarder … @WorkAndPlace
AdvertisementsIn this guide, you will learn how to disable the Galaxy S8 automatic app updates. Galaxy S8 is a flagship smartphone and it works well even in 2020. It comes with the Snapdragon 835 which is still a very capable processor and it can easily beat the mid-range or upper mid-range smartphones available these days. However, it is also a fact that it is an old phone and with the time you will notice some downfall in its performance. It also comes with only 64 GB Storage which is not a lot and you just have to take some measures to save some storage and disabling automatic app updates is one of those measures and we will show you can do it. Let’s get started.
Google Play Store is the main store on Galaxy S8 and you can easily disable the automatic updates on Google Play Store. Here’s how you can do it.
Now tap the three parallel lines icon on the top left corner.
A side menu will appear on the screen, navigate through it and find Settings and tap it.
In the settings, go to General Section and Find Auto-Update Apps.
Tap it and it will display a pop-up on the screen with three options.
Select the “Don’t Auto-Update Apps”.
Congratulations! You have successfully disabled the auto-updates via Google Play Store. Now you will have to manually update the apps which you regularly use and you can ignore the ones which you don’t use very often.
Galaxy S8 also comes with the Galaxy Apps which is the official app store by Samsung. In some versions, Galaxy Apps is not available. If it is not available then don’t worry you are good. If it is available then you will need to disable the automatic app updates on it. Here’s how you can do it.
Open the Galaxy Apps.
Now tap the three parallel line icon on the top right corner to access settings.
In the settings, navigate to the Updates section and then tap it.
Now you will see a pop up on the screen with various options.
Select “Turn Off” to disable the automatic updates.
Congratulations! You have successfully disabled the automatic updates via Galaxy Apps.
That’s how you can disable Galaxy S8 Automatic updates. If you have disabled the automatic updates then we would recommend you to regularly check for the new updates because new updates not only brings new features but also fixes to the security loopholes in the apps. We would also recommend you to only install apps that you regularly use and uninstall the unnecessary apps because doing it will improve the overall performance of your smartphone. If you have any questions, please let us know in the comment section below. Also, if you want to learn how to disable app notifications, then visit our website.
In today’s business environment, it is almost a foregone conclusion that businesses of all sizes are prepared to handle electronic payments. Customers have come to expect the convenience of credit card, debit card, and/or online accessibility. For many businesses, this means working with a credit card payment processor to help accept and track these payments securely.
Choosing a merchant service or payment service provider can be a difficult undertaking. What exactly should you be looking for? Can you get away with a bare bones account or do you need something more robust? Today, we will be exploring the topic of selecting a credit card payment processor with these questions in mind.
What do Credit Card Payment Processors Do?
The old days of cash only businesses are quickly falling by the wayside. For the rest of us, payment processing is a reality of doing business. Even traditional cash/check businesses such as plumbers, landscapers, and food delivery services often offer mobile payment processing for customer convenience.
Credit card payment processors are the companies who process electronic payments via credit cards, debit cards, and sometimes alternative methods. Payment processors assist with the authorization, authentication, and settlement of credit card payments.
This involves interfacing directly with the issuing bank for credit and/or debit cards, the credit card company itself, and the bank receiving payment (the merchant’s bank). While it isn’t necessary to understand every little detail of this process, it is important to understand that payment processors take on the heavy lifting of clearing electronic payments.
Merchant accounts are ideal for businesses clearing over $10,000 in electronic payments per month. Merchant accounts are the more robust option and generally offer the best rates for higher volume businesses. One of the key advantages of a merchant account arrangement is that it comes with a direct relationship with the processing bank. This direct relationship comes with improved rates and potentially more responsive customer service.
PSP accounts are better suited for merchants who process $5,000 or less in electronic payments per month. Note that the $5k to $10k range is in the middle, and merchants in this range may want to consider both options before making an informed decision. PSP accounts flow through a third-party processor in lieu of the merchant having their own account. Even though rates may be higher, some small businesses still save money as PSP accounts generally have no monthly fees. The potential downside is less personalization and customer service accessibility.
What often gets lost in the shuffle of buzzwords and numbers is customer service and a solid platform. Payment processors are an incredibly important part of most businesses. For example, if there is an accusation of fraud, inferior payment processors may not have the knowledge or resources to help. This may lead to chargebacks, account suspensions, or even account terminations.
Choosing the correct payment processor is more than just looking at the basic rates. Many processors charge monthly fees, processing fees, qualified vs. non-qualified rates, and other hidden fees. Always strive to understand exactly how and what you will be charged before entering into a relationship with a payment processor. Look for payment processing organizations who are experienced with a proven track record of success.
Even the most high tech and well-fin