 of in every-day life. Thus the true business college performs a twofold function. As a technical school it trains its students for a specific occupation, that of the accountant; at the same time it supplements the education not only...
... pistol, and a powder-flask on the table; two Irish emigrant women were seated on the floor (which swarmed with black beetles and ants), undressing a screaming child; a woman evidently in a fever was tossing restlessly on the sofa; two females in tarnished Bloomer habiliments were looking out of the window; and other extraordinary- looking human beings filled the room. I asked for accommodation for the night,...
... still be a boor; but a man can not be a person of good education and not be—so far as manner is concerned—a gentleman. Education, then, is a whole of which Instruction and Breeding are the parts. The man or the woman—even in this democratic country of ours—who deserves the title of gentleman or lady is always a person of education; i. e., he or she has a sufficient acquaintance with books and with the usages of social intercourse to acquit himself or herself...
... merchant. Here are some of the facts that he has recorded in his diary. LeGris, the Little Turtle, Richardville, and Blue Jacket, the Shawnee chief, were all in that vicinity. George Girty lived close by in a Delaware town. He had married an Indian woman and was really a savage. On the twenty-sixth of December 1789, Girty came to Miamitown to report to Hay. He said that the Delawares were constantly being told by the Miamis that the ground they occupied was not theirs; that the Delawares had answered that they were great fools to fight...
... son of Charles Buller (d. 1848), a member of a well-known Cornish family (see below), was born in Calcutta on the 6th of August 1806; his mother, a daughter of General William Kirkpatrick, was an exceptionally talented woman. He was educated at Harrow, then privately in Edinburgh by Thomas Carlyle, and afterwards at Trinity College, Cambridge, becoming a barrister in 1831. Before this date, however, he had succeeded his father as member of parliament for West Looe; after the passing of the Reform Bill of 1832 and...
... belonging to me who earned their livelihood in foreign countries and by dangerous ways, but you may trust your old mother to learn to do and bear what other mothers go through with. She will learn to love the sea because you are a sailor, but, Jack, you must always give her a woman's bitter-sweet privilege of saying good-bye, and of packing up your things. I am getting the time over till you come back with socks. I am afraid they will blister your feet. Martha does not like them because they are...
... the very air is full of stories concerning battles which have not been fought and victories which have not been won. From mouth to mouth, all along the lines, the stories run as fire runs along fuse, and no man born of woman can tell whence they came or where they will stop. Each soldier questioned swears the tale is true, because "'twas told to him by one who never lied." Yet, at evening, when the weary wretch who works for newspapers returns to his tent, with his boots worn through with fruitless search for...
... Twemlow, polite little gentleman that he is. 'A woman's tact is invaluable. To have the dear sex with us, is...
... specific facts, but erroneous in his general results. He will say the same of me, perhaps. Ballantyne and Cadell leave us. Enter Miss Sinclairs, two in number, also a translator, and a little Flemish woman, his wife—very good-humoured, rather a little given to compliment; name Fauconpret. They are to return at night in a gig as far as...
... pure, and almost transparent profile and the long, dark waves of the hair, which was smoothed down at the temples. I used to see this face standing out on the brilliant background of the window, which was lighted from a lamp in the bedroom. At times, too, I had heard a woman's voice saying a few words or giving some orders in the apartment. The slightly foreign, though pure accent, the vibrations of that soft, languid, and yet marvellously sonorous voice, of which I heard the harmony without understanding the words had interested me. Long after my window was closed that...
... true, that, before the revolution, I have here witnessed repeated accidents of the most serious nature, resulting from the exercise of this sort of ministerial privilege: on one occasion particularly, I myself narrowly escaped unhurt, when a decent, elderly woman was thrown down, close by my feet, and had both her thighs broken through the unfeeling wantonness of the coachman of the Baron de Breteuil, at that time minister for the department...
... them—but no words. His fingers touched her hair. When she looked at him again through her tears, the eyes were closed, and the face bore an austere look of preoccupation, as of one withdrawn from the business of life.... Afterwards the nurse touched the kneeling woman, the doctor came, she was led away. She knew that...
... horror tore its way from the throat of every sleeper at once, and shot into every cranny of the many-folded mountains, that my soul knocked shaking against the sides of my body, and I also shrieked aloud with the keen terror of the cry. For surely there was no sleeper there, man, woman, or child, who yelled not aloud in an agony of fear. And I knew that it could only be because of the unseen presence in their street of the outcast, the homeless, the loveless, the wanderer for ever, who had refused a stone to his maker whereon to rest his cross....
... already stood. He had an unyielding habit of tidiness and hated to see children playing in a road; and he hated worse to see a motor-car come faster round a corner than it did ought; or any sign of unsteady steps in a man or woman, who'd stopped too long at the 'Queen Anne' public-house, or anything like that. He weren't what you might call an amusing man and he hadn't yet reached the stage to make allowances and keep his weather eye shut when the occasion demanded...
The FDA has approved trastuzumab deruxtecan (fam-trastuzumab-deruxtecan-nxki, or ENHERTU) for patients with breast cancer with HER2+, unresectable and/or metastatic disease who failed ≥2 prior anti-HER2+ drug regimens.
This antibody-drug conjugate has high response rate (60.3%), but carries a boxed warning for interstitial lung disease (ILD).
Trastuzumab deruxtecan is an alternative to trastuzumab emtansine with more potent cytotoxicity.
A boxed warning requires monitoring for signs and symptoms of ILD, including cough and dyspnea.
If symptoms of ILD reach at least grade 2, the FDA says the antibody-drug conjugate should be permanently discontinued.
The European Medicines Agency has not yet approved the antibody-drug conjugate.
Recommended dose: 5.4 mg/kg by intravenous infusion every 3 weeks until disease progression or unacceptable toxicity.
4.3% with complete response.
56% with a partial response.
Median response duration: 14.8 (95% CI, 13.8-16.9) months.
ILD was reported in 9% of patients, 4 of whom died (2.6% of total patients).
The boxed warning also advises against receiving trastuzumab deruxtecan while pregnant because of embryo-fetal harm.LED products energy-saving, environmental protection of image has been deeply rooted in the hearts of the people
by：ALLTOP 2019-12-19
Heyuan city, a prefecture-level city affiliated to Guangdong province, is located in the northern part of Guangdong province and is one of the main settlements of Hakka people. As a third-tier city, Heyuan's tourism industry has developed rapidly in recent years. At the same time, commerce in various fields has also changed under the drive of tourism economy. Recently, I visited Heyuan city in Guangdong province to visit the lighting market of Hakka ancient city, which has a history of more than two thousand years. During the visit, the author found that with the rapid development of LED, the lighting market pattern in Heyuan city is also quietly changing. The competition in the industry has intensified, and the operation of physical stores is difficult. Unlike many cities, so far, there is no centralized lighting store in Heyuan city. The sales of lamps and lanterns are mainly in the form of hardware stores, scattered home building materials stores, and decorative materials supermarkets. Among them, hardware stores are located in all streets of Heyuan city, while home building materials stores and decoration materials supermarkets are concentrated on Hongxing Road on Zhongshan Avenue. There, the author visited the specialty stores of Rex, sanxiong, pinshang lighting and other brands, and learned that even Rex and sanxiong are giant brands in the domestic lighting industry, here, it can only be mixed with doors and windows, and other low-priced products of miscellaneous brands. The heads of the two stores said that the products of big brands in Heyuan city can only live through