Daily Papers

The rapid advancement of Artificial Intelligence (AI) in biomedical imaging and radiotherapy is hindered by the limited availability of large imaging data repositories. With recent research and improvements in denoising diffusion probabilistic models (DDPM), high quality synthetic medical scans are now possible. Despite this, there is currently no way of generating multiple related images, such as a corresponding ground truth which can be used to train models, so synthetic scans are often manually annotated before use. This research introduces a novel architecture that is able to generate multiple, related PET-CT-tumour mask pairs using paired networks and conditional encoders. Our approach includes innovative, time step-controlled mechanisms and a `noise-seeding' strategy to improve DDPM sampling consistency. While our model requires a modified perceptual loss function to ensure accurate feature alignment we show generation of clearly aligned synthetic images and improvement in segmentation accuracy with generated images.

Known for efficient computation and easy storage, hashing has been extensively explored in cross-modal retrieval. The majority of current hashing models are predicated on the premise of a direct one-to-one mapping between data points. However, in real practice, data correspondence across modalities may be partially provided. In this research, we introduce an innovative unsupervised hashing technique designed for semi-paired cross-modal retrieval tasks, named Reconstruction Relations Embedded Hashing (RREH). RREH assumes that multi-modal data share a common subspace. For paired data, RREH explores the latent consistent information of heterogeneous modalities by seeking a shared representation. For unpaired data, to effectively capture the latent discriminative features, the high-order relationships between unpaired data and anchors are embedded into the latent subspace, which are computed by efficient linear reconstruction. The anchors are sampled from paired data, which improves the efficiency of hash learning. The RREH trains the underlying features and the binary encodings in a unified framework with high-order reconstruction relations preserved. With the well devised objective function and discrete optimization algorithm, RREH is designed to be scalable, making it suitable for large-scale datasets and facilitating efficient cross-modal retrieval. In the evaluation process, the proposed is tested with partially paired data to establish its superiority over several existing methods.

Antibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in the design of better therapeutics has been constrained by the sheer volume and complexity of the data. To address this challenge, we present IgBert and IgT5, the best performing antibody-specific language models developed to date which can consistently handle both paired and unpaired variable region sequences as input. These models are trained comprehensively using the more than two billion unpaired sequences and two million paired sequences of light and heavy chains present in the Observed Antibody Space dataset. We show that our models outperform existing antibody and protein language models on a diverse range of design and regression tasks relevant to antibody engineering. This advancement marks a significant leap forward in leveraging machine learning, large scale data sets and high-performance computing for enhancing antibody design for therapeutic development.

The introduction of large, foundational models to computer vision has led to drastically improved performance on the task of semantic segmentation. However, these existing methods exhibit a large performance drop when testing on images degraded by weather conditions such as rain, fog, or snow. We introduce a general paired-training method that can be applied to all current foundational model architectures that leads to improved performance on images in adverse weather conditions. To this end, we create the WeatherProof Dataset, the first semantic segmentation dataset with accurate clear and adverse weather image pairs, which not only enables our new training paradigm, but also improves the evaluation of the performance gap between clear and degraded segmentation. We find that training on these paired clear and adverse weather frames which share an underlying scene results in improved performance on adverse weather data. With this knowledge, we propose a training pipeline which accentuates the advantages of paired-data training using consistency losses and language guidance, which leads to performance improvements by up to 18.4% as compared to standard training procedures.

It is very challenging for various visual tasks such as image fusion, pedestrian detection and image-to-image translation in low light conditions due to the loss of effective target areas. In this case, infrared and visible images can be used together to provide both rich detail information and effective target areas. In this paper, we present LLVIP, a visible-infrared paired dataset for low-light vision. This dataset contains 30976 images, or 15488 pairs, most of which were taken at very dark scenes, and all of the images are strictly aligned in time and space. Pedestrians in the dataset are labeled. We compare the dataset with other visible-infrared datasets and evaluate the performance of some popular visual algorithms including image fusion, pedestrian detection and image-to-image translation on the dataset. The experimental results demonstrate the complementary effect of fusion on image information, and find the deficiency of existing algorithms of the three visual tasks in very low-light conditions. We believe the LLVIP dataset will contribute to the community of computer vision by promoting image fusion, pedestrian detection and image-to-image translation in very low-light applications. The dataset is being released in https://bupt-ai-cz.github.io/LLVIP. Raw data is also provided for further research such as image registration.

Recent advancements in Large Multimodal Models (LMMs) have leveraged extensive multimodal datasets to enhance capabilities in complex knowledge-driven tasks. However, persistent challenges in perceptual and reasoning errors limit their efficacy, particularly in interpreting intricate visual data and deducing multimodal relationships. Addressing these issues, we introduce a novel dataset format, PIN (Paired and INterleaved multimodal documents), designed to significantly improve both the depth and breadth of multimodal training. The PIN format is built on three foundational principles: knowledge intensity, scalability, and support for diverse training modalities. This innovative format combines markdown files and comprehensive images to enrich training data with a dense knowledge structure and versatile training strategies. We present PIN-14M, an open-source dataset comprising 14 million samples derived from a diverse range of Chinese and English sources, tailored to include complex web and scientific content. This dataset is constructed meticulously to ensure data quality and ethical integrity, aiming to facilitate advanced training strategies and improve model robustness against common multimodal training pitfalls. Our initial results, forming the basis of this technical report, suggest significant potential for the PIN format in refining LMM performance, with plans for future expansions and detailed evaluations of its impact on model capabilities.

Image editing using diffusion models has witnessed extremely fast-paced growth recently. There are various ways in which previous works enable controlling and editing images. Some works use high-level conditioning such as text, while others use low-level conditioning. Nevertheless, most of them lack fine-grained control over the properties of the different objects present in the image, i.e. object-level image editing. In this work, we consider an image as a composition of multiple objects, each defined by various properties. Out of these properties, we identify structure and appearance as the most intuitive to understand and useful for editing purposes. We propose Structure-and-Appearance Paired Diffusion model (PAIR-Diffusion), which is trained using structure and appearance information explicitly extracted from the images. The proposed model enables users to inject a reference image's appearance into the input image at both the object and global levels. Additionally, PAIR-Diffusion allows editing the structure while maintaining the style of individual components of the image unchanged. We extensively evaluate our method on LSUN datasets and the CelebA-HQ face dataset, and we demonstrate fine-grained control over both structure and appearance at the object level. We also applied the method to Stable Diffusion to edit any real image at the object level.

Learning visual representations of medical images (e.g., X-rays) is core to medical image understanding but its progress has been held back by the scarcity of human annotations. Existing work commonly relies on fine-tuning weights transferred from ImageNet pretraining, which is suboptimal due to drastically different image characteristics, or rule-based label extraction from the textual report data paired with medical images, which is inaccurate and hard to generalize. Meanwhile, several recent studies show exciting results from unsupervised contrastive learning from natural images, but we find these methods help little on medical images because of their high inter-class similarity. We propose ConVIRT, an alternative unsupervised strategy to learn medical visual representations by exploiting naturally occurring paired descriptive text. Our new method of pretraining medical image encoders with the paired text data via a bidirectional contrastive objective between the two modalities is domain-agnostic, and requires no additional expert input. We test ConVIRT by transferring our pretrained weights to 4 medical image classification tasks and 2 zero-shot retrieval tasks, and show that it leads to image representations that considerably outperform strong baselines in most settings. Notably, in all 4 classification tasks, our method requires only 10\% as much labeled training data as an ImageNet initialized counterpart to achieve better or comparable performance, demonstrating superior data efficiency.

Deep learning-based methods have achieved remarkable success in image restoration and enhancement, but are they still competitive when there is a lack of paired training data? As one such example, this paper explores the low-light image enhancement problem, where in practice it is extremely challenging to simultaneously take a low-light and a normal-light photo of the same visual scene. We propose a highly effective unsupervised generative adversarial network, dubbed EnlightenGAN, that can be trained without low/normal-light image pairs, yet proves to generalize very well on various real-world test images. Instead of supervising the learning using ground truth data, we propose to regularize the unpaired training using the information extracted from the input itself, and benchmark a series of innovations for the low-light image enhancement problem, including a global-local discriminator structure, a self-regularized perceptual loss fusion, and attention mechanism. Through extensive experiments, our proposed approach outperforms recent methods under a variety of metrics in terms of visual quality and subjective user study. Thanks to the great flexibility brought by unpaired training, EnlightenGAN is demonstrated to be easily adaptable to enhancing real-world images from various domains. The code is available at https://github.com/yueruchen/EnlightenGAN

Effective information retrieval (IR) from vast datasets relies on advanced techniques to extract relevant information in response to queries. Recent advancements in dense retrieval have showcased remarkable efficacy compared to traditional sparse retrieval methods. To further enhance retrieval performance, knowledge distillation techniques, often leveraging robust cross-encoder rerankers, have been extensively explored. However, existing approaches primarily distill knowledge from pointwise rerankers, which assign absolute relevance scores to documents, thus facing challenges related to inconsistent comparisons. This paper introduces Pairwise Relevance Distillation (PairDistill) to leverage pairwise reranking, offering fine-grained distinctions between similarly relevant documents to enrich the training of dense retrieval models. Our experiments demonstrate that PairDistill outperforms existing methods, achieving new state-of-the-art results across multiple benchmarks. This highlights the potential of PairDistill in advancing dense retrieval techniques effectively. Our source code and trained models are released at https://github.com/MiuLab/PairDistill

Neural Radiance Fields (NeRFs) excel in photorealistically rendering static scenes. However, rendering dynamic, long-duration radiance fields on ubiquitous devices remains challenging, due to data storage and computational constraints. In this paper, we introduce VideoRF, the first approach to enable real-time streaming and rendering of dynamic radiance fields on mobile platforms. At the core is a serialized 2D feature image stream representing the 4D radiance field all in one. We introduce a tailored training scheme directly applied to this 2D domain to impose the temporal and spatial redundancy of the feature image stream. By leveraging the redundancy, we show that the feature image stream can be efficiently compressed by 2D video codecs, which allows us to exploit video hardware accelerators to achieve real-time decoding. On the other hand, based on the feature image stream, we propose a novel rendering pipeline for VideoRF, which has specialized space mappings to query radiance properties efficiently. Paired with a deferred shading model, VideoRF has the capability of real-time rendering on mobile devices thanks to its efficiency. We have developed a real-time interactive player that enables online streaming and rendering of dynamic scenes, offering a seamless and immersive free-viewpoint experience across a range of devices, from desktops to mobile phones.

Predicting which proteins interact together from amino-acid sequences is an important task. We develop a method to pair interacting protein sequences which leverages the power of protein language models trained on multiple sequence alignments, such as MSA Transformer and the EvoFormer module of AlphaFold. We formulate the problem of pairing interacting partners among the paralogs of two protein families in a differentiable way. We introduce a method called DiffPALM that solves it by exploiting the ability of MSA Transformer to fill in masked amino acids in multiple sequence alignments using the surrounding context. MSA Transformer encodes coevolution between functionally or structurally coupled amino acids. We show that it captures inter-chain coevolution, while it was trained on single-chain data, which means that it can be used out-of-distribution. Relying on MSA Transformer without fine-tuning, DiffPALM outperforms existing coevolution-based pairing methods on difficult benchmarks of shallow multiple sequence alignments extracted from ubiquitous prokaryotic protein datasets. It also outperforms an alternative method based on a state-of-the-art protein language model trained on single sequences. Paired alignments of interacting protein sequences are a crucial ingredient of supervised deep learning methods to predict the three-dimensional structure of protein complexes. DiffPALM substantially improves the structure prediction of some eukaryotic protein complexes by AlphaFold-Multimer, without significantly deteriorating any of those we tested. It also achieves competitive performance with using orthology-based pairing.

Retrieval-augmented generation has gained significant attention due to its ability to integrate relevant external knowledge, enhancing the accuracy and reliability of the LLMs' responses. Most of the existing methods apply a dynamic multiple retrieval-generating process, to address multi-hop complex questions by decomposing them into sub-problems. However, these methods rely on an unidirectional forward reasoning paradigm, where errors from insufficient reasoning steps or inherent flaws in current retrieval systems are irreversible, potentially derailing the entire reasoning chain. For the first time, this work introduces Retroactive Retrieval-Augmented Generation (RetroRAG), a novel framework to build a retroactive reasoning paradigm. RetroRAG revises and updates the evidence, redirecting the reasoning chain to the correct direction. RetroRAG constructs an evidence-collation-discovery framework to search, generate, and refine credible evidence. It synthesizes inferential evidence related to the key entities in the question from the existing source knowledge and formulates search queries to uncover additional information. As new evidence is found, RetroRAG continually updates and organizes this information, enhancing its ability to locate further necessary evidence. Paired with an Answerer to generate and evaluate outputs, RetroRAG is capable of refining its reasoning process iteratively until a reliable answer is obtained. Empirical evaluations show that RetroRAG significantly outperforms existing methods.

We propose an adaptive training scheme for unsupervised medical image registration. Existing methods rely on image reconstruction as the primary supervision signal. However, nuisance variables (e.g. noise and covisibility), violation of the Lambertian assumption in physical waves (e.g. ultrasound), and inconsistent image acquisition can all cause a loss of correspondence between medical images. As the unsupervised learning scheme relies on intensity constancy between images to establish correspondence for reconstruction, this introduces spurious error residuals that are not modeled by the typical training objective. To mitigate this, we propose an adaptive framework that re-weights the error residuals with a correspondence scoring map during training, preventing the parametric displacement estimator from drifting away due to noisy gradients, which leads to performance degradation. To illustrate the versatility and effectiveness of our method, we tested our framework on three representative registration architectures across three medical image datasets along with other baselines. Our adaptive framework consistently outperforms other methods both quantitatively and qualitatively. Paired t-tests show that our improvements are statistically significant. Code available at: https://voldemort108x.github.io/AdaCS/.

Transformers are quickly becoming one of the most heavily applied deep learning architectures across modalities, domains, and tasks. In vision, on top of ongoing efforts into plain transformers, hierarchical transformers have also gained significant attention, thanks to their performance and easy integration into existing frameworks. These models typically employ localized attention mechanisms, such as the sliding-window Neighborhood Attention (NA) or Swin Transformer's Shifted Window Self Attention. While effective at reducing self attention's quadratic complexity, local attention weakens two of the most desirable properties of self attention: long range inter-dependency modeling, and global receptive field. In this paper, we introduce Dilated Neighborhood Attention (DiNA), a natural, flexible and efficient extension to NA that can capture more global context and expand receptive fields exponentially at no additional cost. NA's local attention and DiNA's sparse global attention complement each other, and therefore we introduce Dilated Neighborhood Attention Transformer (DiNAT), a new hierarchical vision transformer built upon both. DiNAT variants enjoy significant improvements over strong baselines such as NAT, Swin, and ConvNeXt. Our large model is faster and ahead of its Swin counterpart by 1.6% box AP in COCO object detection, 1.4% mask AP in COCO instance segmentation, and 1.4% mIoU in ADE20K semantic segmentation. Paired with new frameworks, our large variant is the new state of the art panoptic segmentation model on COCO (58.5 PQ) and ADE20K (49.4 PQ), and instance segmentation model on Cityscapes (45.1 AP) and ADE20K (35.4 AP) (no extra data). It also matches the state of the art specialized semantic segmentation models on ADE20K (58.1 mIoU), and ranks second on Cityscapes (84.5 mIoU) (no extra data).

The privacy concerns of providing deep learning inference as a service have underscored the need for private inference (PI) protocols that protect users' data and the service provider's model using cryptographic methods. Recently proposed PI protocols have achieved significant reductions in PI latency by moving the computationally heavy homomorphic encryption (HE) parts to an offline/pre-compute phase. Paired with recent optimizations that tailor networks for PI, these protocols have achieved performance levels that are tantalizingly close to being practical. In this paper, we conduct a rigorous end-to-end characterization of PI protocols and optimization techniques and find that the current understanding of PI performance is overly optimistic. Specifically, we find that offline storage costs of garbled circuits (GC), a key cryptographic protocol used in PI, on user/client devices are prohibitively high and force much of the expensive offline HE computation to the online phase, resulting in a 10-1000times increase to PI latency. We propose a modified PI protocol that significantly reduces client-side storage costs for a small increase in online latency. Evaluated end-to-end, the modified protocol outperforms current protocols by reducing the mean PI latency by 4times for ResNet18 on TinyImageNet. We conclude with a discussion of several recently proposed PI optimizations in light of the findings and note many actually increase PI latency when evaluated from an end-to-end perspective.

Event cameras have recently gained significant traction since they open up new avenues for low-latency and low-power solutions to complex computer vision problems. To unlock these solutions, it is necessary to develop algorithms that can leverage the unique nature of event data. However, the current state-of-the-art is still highly influenced by the frame-based literature, and usually fails to deliver on these promises. In this work, we take this into consideration and propose a novel self-supervised learning pipeline for the sequential estimation of event-based optical flow that allows for the scaling of the models to high inference frequencies. At its core, we have a continuously-running stateful neural model that is trained using a novel formulation of contrast maximization that makes it robust to nonlinearities and varying statistics in the input events. Results across multiple datasets confirm the effectiveness of our method, which establishes a new state of the art in terms of accuracy for approaches trained or optimized without ground truth.

Offline paired preference optimization algorithms have become a popular approach for fine-tuning on preference data, outperforming traditional supervised fine-tuning in various tasks. However, traditional implementations often involve redundant computations, especially for tasks with long shared prompts. We introduce prefix sharing for preference tuning, a novel technique that processes chosen and rejected responses as one sequence with a shared prefix. To prevent cross-response contamination, we use a custom block-sparse attention mask. Our method achieves 1.1-1.5times improvement in training throughput on popular DPO datasets, without any effect on convergence. When combined with sequence packing, we observe consistent 1.3-1.6times speedups, benefiting even datasets with smaller sequence lengths. While we focus on Direct Preference Optimization (DPO), our approach is applicable to other paired preference tuning methods. By enhancing computational efficiency, our work contributes to making preference-based fine-tuning more accessible for a wider range of applications and model sizes. We open-source our code at https://github.com/frankxwang/dpo-prefix-sharing.

In this work, we present MedImageInsight, an open-source medical imaging embedding model. MedImageInsight is trained on medical images with associated text and labels across a diverse collection of domains, including X-Ray, CT, MRI, dermoscopy, OCT, fundus photography, ultrasound, histopathology, and mammography. Rigorous evaluations demonstrate MedImageInsight's ability to achieve state-of-the-art (SOTA) or human expert level performance across classification, image-image search, and fine-tuning tasks. Specifically, on public datasets, MedImageInsight achieves SOTA in CT 3D medical image retrieval, as well as SOTA in disease classification and search for chest X-ray, dermatology, and OCT imaging. Furthermore, MedImageInsight achieves human expert performance in bone age estimation (on both public and partner data), as well as AUC above 0.9 in most other domains. When paired with a text decoder, MedImageInsight achieves near SOTA level single image report findings generation with less than 10\% the parameters of other models. Compared to fine-tuning GPT-4o with only MIMIC-CXR data for the same task, MedImageInsight outperforms in clinical metrics, but underperforms on lexical metrics where GPT-4o sets a new SOTA. Importantly for regulatory purposes, MedImageInsight can generate ROC curves, adjust sensitivity and specificity based on clinical need, and provide evidence-based decision support through image-image search (which can also enable retrieval augmented generation). In an independent clinical evaluation of image-image search in chest X-ray, MedImageInsight outperformed every other publicly available foundation model evaluated by large margins (over 6 points AUC), and significantly outperformed other models in terms of AI fairness (across age and gender). We hope releasing MedImageInsight will help enhance collective progress in medical imaging AI research and development.

The field of robotics has made significant advances towards generalist robot manipulation policies. However, real-world evaluation of such policies is not scalable and faces reproducibility challenges, which are likely to worsen as policies broaden the spectrum of tasks they can perform. We identify control and visual disparities between real and simulated environments as key challenges for reliable simulated evaluation and propose approaches for mitigating these gaps without needing to craft full-fidelity digital twins of real-world environments. We then employ these approaches to create SIMPLER, a collection of simulated environments for manipulation policy evaluation on common real robot setups. Through paired sim-and-real evaluations of manipulation policies, we demonstrate strong correlation between policy performance in SIMPLER environments and in the real world. Additionally, we find that SIMPLER evaluations accurately reflect real-world policy behavior modes such as sensitivity to various distribution shifts. We open-source all SIMPLER environments along with our workflow for creating new environments at https://simpler-env.github.io to facilitate research on general-purpose manipulation policies and simulated evaluation frameworks.

Invasive plant species are detrimental to the ecology of both agricultural and wildland areas. Euphorbia esula, or leafy spurge, is one such plant that has spread through much of North America from Eastern Europe. When paired with contemporary computer vision systems, unmanned aerial vehicles, or drones, offer the means to track expansion of problem plants, such as leafy spurge, and improve chances of controlling these weeds. We gathered a dataset of leafy spurge presence and absence in grasslands of western Montana, USA, then surveyed these areas with a commercial drone. We trained image classifiers on these data, and our best performing model, a pre-trained DINOv2 vision transformer, identified leafy spurge with 0.84 accuracy (test set). This result indicates that classification of leafy spurge is tractable, but not solved. We release this unique dataset of labelled and unlabelled, aerial drone imagery for the machine learning community to explore. Improving classification performance of leafy spurge would benefit the fields of ecology, conservation, and remote sensing alike. Code and data are available at our website: leafy-spurge-dataset.github.io.

A style mapper applies some fixed style to its input images (so, for example, taking faces to cartoons). This paper describes a simple procedure -- JoJoGAN -- to learn a style mapper from a single example of the style. JoJoGAN uses a GAN inversion procedure and StyleGAN's style-mixing property to produce a substantial paired dataset from a single example style. The paired dataset is then used to fine-tune a StyleGAN. An image can then be style mapped by GAN-inversion followed by the fine-tuned StyleGAN. JoJoGAN needs just one reference and as little as 30 seconds of training time. JoJoGAN can use extreme style references (say, animal faces) successfully. Furthermore, one can control what aspects of the style are used and how much of the style is applied. Qualitative and quantitative evaluation show that JoJoGAN produces high quality high resolution images that vastly outperform the current state-of-the-art.

We present the Neural Waveshaping Unit (NEWT): a novel, lightweight, fully causal approach to neural audio synthesis which operates directly in the waveform domain, with an accompanying optimisation (FastNEWT) for efficient CPU inference. The NEWT uses time-distributed multilayer perceptrons with periodic activations to implicitly learn nonlinear transfer functions that encode the characteristics of a target timbre. Once trained, a NEWT can produce complex timbral evolutions by simple affine transformations of its input and output signals. We paired the NEWT with a differentiable noise synthesiser and reverb and found it capable of generating realistic musical instrument performances with only 260k total model parameters, conditioned on F0 and loudness features. We compared our method to state-of-the-art benchmarks with a multi-stimulus listening test and the Fr\'echet Audio Distance and found it performed competitively across the tested timbral domains. Our method significantly outperformed the benchmarks in terms of generation speed, and achieved real-time performance on a consumer CPU, both with and without FastNEWT, suggesting it is a viable basis for future creative sound design tools.