new

Get trending papers in your email inbox!

Subscribe

byAK and the research community

Mar 12

XMainframe: A Large Language Model for Mainframe Modernization

Mainframe operating systems, despite their inception in the 1940s, continue to support critical sectors like finance and government. However, these systems are often viewed as outdated, requiring extensive maintenance and modernization. Addressing this challenge necessitates innovative tools that can understand and interact with legacy codebases. To this end, we introduce XMainframe, a state-of-the-art large language model (LLM) specifically designed with knowledge of mainframe legacy systems and COBOL codebases. Our solution involves the creation of an extensive data collection pipeline to produce high-quality training datasets, enhancing XMainframe's performance in this specialized domain. Additionally, we present MainframeBench, a comprehensive benchmark for assessing mainframe knowledge, including multiple-choice questions, question answering, and COBOL code summarization. Our empirical evaluations demonstrate that XMainframe consistently outperforms existing state-of-the-art LLMs across these tasks. Specifically, XMainframe achieves 30% higher accuracy than DeepSeek-Coder on multiple-choice questions, doubles the BLEU score of Mixtral-Instruct 8x7B on question answering, and scores six times higher than GPT-3.5 on COBOL summarization. Our work highlights the potential of XMainframe to drive significant advancements in managing and modernizing legacy systems, thereby enhancing productivity and saving time for software developers.

With Greater Text Comes Greater Necessity: Inference-Time Training Helps Long Text Generation

Long text generation, such as novel writing and discourse-level translation with extremely long contexts, presents significant challenges to current language models. Existing methods mainly focus on extending the model's context window through strategies like length extrapolation. However, these approaches demand substantial hardware resources during the training and/or inference phases. Our proposed method, Temp-Lora, introduces an alternative concept. Instead of relying on the KV cache to store all context information, we embeds this information directly into a temporary Lora module. In the process of long text generation, this module is progressively trained with text generated previously. This approach not only efficiently preserves contextual knowledge but also prevents any permanent alteration to the model's parameters given that the module is discarded post-generation. Extensive experiments on the PG19 language modeling benchmark and the GuoFeng discourse-level translation benchmark validate the effectiveness of Temp-Lora. Our results show that: 1) Temp-Lora substantially enhances generation quality for long text, as indicated by a 13.2% decrease in perplexity (PPL) on a subset of PG19, and a 29.3% decrease in PPL along with a 113.2% increase in BLEU score on a subset of GuoFeng, 2) Temp-Lora is compatible with and enhances most existing long text generation methods, and 3) Temp-Lora can greatly reduce computational costs by shortening the context window. For example, we can ensure a moderate improvement in generation quality (a decrease of 3.8% in PPL) while enabling a 51.5% memory usage reduction and a 60.0% decrease in latency for inference.

Development of a Large-scale Dataset of Chest Computed Tomography Reports in Japanese and a High-performance Finding Classification Model

Background: Recent advances in large language models highlight the need for high-quality multilingual medical datasets. While Japan leads globally in CT scanner deployment and utilization, the lack of large-scale Japanese radiology datasets has hindered the development of specialized language models for medical imaging analysis. Objective: To develop a comprehensive Japanese CT report dataset through machine translation and establish a specialized language model for structured finding classification. Additionally, to create a rigorously validated evaluation dataset through expert radiologist review. Methods: We translated the CT-RATE dataset (24,283 CT reports from 21,304 patients) into Japanese using GPT-4o mini. The training dataset consisted of 22,778 machine-translated reports, while the validation dataset included 150 radiologist-revised reports. We developed CT-BERT-JPN based on "tohoku-nlp/bert-base-japanese-v3" architecture for extracting 18 structured findings from Japanese radiology reports. Results: Translation metrics showed strong performance with BLEU scores of 0.731 and 0.690, and ROUGE scores ranging from 0.770 to 0.876 for Findings and from 0.748 to 0.857 for Impression sections. CT-BERT-JPN demonstrated superior performance compared to GPT-4o in 11 out of 18 conditions, including lymphadenopathy (+14.2%), interlobular septal thickening (+10.9%), and atelectasis (+7.4%). The model maintained F1 scores exceeding 0.95 in 14 out of 18 conditions and achieved perfect scores in four conditions. Conclusions: Our study establishes a robust Japanese CT report dataset and demonstrates the effectiveness of a specialized language model for structured finding classification. The hybrid approach of machine translation and expert validation enables the creation of large-scale medical datasets while maintaining high quality.

Towards Accurate Differential Diagnosis with Large Language Models

An accurate differential diagnosis (DDx) is a cornerstone of medical care, often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive interfaces powered by Large Language Models (LLMs) present new opportunities to both assist and automate aspects of this process. In this study, we introduce an LLM optimized for diagnostic reasoning, and evaluate its ability to generate a DDx alone or as an aid to clinicians. 20 clinicians evaluated 302 challenging, real-world medical cases sourced from the New England Journal of Medicine (NEJM) case reports. Each case report was read by two clinicians, who were randomized to one of two assistive conditions: either assistance from search engines and standard medical resources, or LLM assistance in addition to these tools. All clinicians provided a baseline, unassisted DDx prior to using the respective assistive tools. Our LLM for DDx exhibited standalone performance that exceeded that of unassisted clinicians (top-10 accuracy 59.1% vs 33.6%, [p = 0.04]). Comparing the two assisted study arms, the DDx quality score was higher for clinicians assisted by our LLM (top-10 accuracy 51.7%) compared to clinicians without its assistance (36.1%) (McNemar's Test: 45.7, p < 0.01) and clinicians with search (44.4%) (4.75, p = 0.03). Further, clinicians assisted by our LLM arrived at more comprehensive differential lists than those without its assistance. Our study suggests that our LLM for DDx has potential to improve clinicians' diagnostic reasoning and accuracy in challenging cases, meriting further real-world evaluation for its ability to empower physicians and widen patients' access to specialist-level expertise.

Assessing Translation capabilities of Large Language Models involving English and Indian Languages

Generative Large Language Models (LLMs) have achieved remarkable advancements in various NLP tasks. In this work, our aim is to explore the multilingual capabilities of large language models by using machine translation as a task involving English and 22 Indian languages. We first investigate the translation capabilities of raw large language models, followed by exploring the in-context learning capabilities of the same raw models. We fine-tune these large language models using parameter efficient fine-tuning methods such as LoRA and additionally with full fine-tuning. Through our study, we have identified the best performing large language model for the translation task involving LLMs, which is based on LLaMA. Our results demonstrate significant progress, with average BLEU scores of 13.42, 15.93, 12.13, 12.30, and 12.07, as well as CHRF scores of 43.98, 46.99, 42.55, 42.42, and 45.39, respectively, using 2-stage fine-tuned LLaMA-13b for English to Indian languages on IN22 (conversational), IN22 (general), flores200-dev, flores200-devtest, and newstest2019 testsets. Similarly, for Indian languages to English, we achieved average BLEU scores of 14.03, 16.65, 16.17, 15.35 and 12.55 along with chrF scores of 36.71, 40.44, 40.26, 39.51, and 36.20, respectively, using fine-tuned LLaMA-13b on IN22 (conversational), IN22 (general), flores200-dev, flores200-devtest, and newstest2019 testsets. Overall, our findings highlight the potential and strength of large language models for machine translation capabilities, including for languages that are currently underrepresented in LLMs.

Deep Learning Segmentation of Ascites on Abdominal CT Scans for Automatic Volume Quantification

Purpose: To evaluate the performance of an automated deep learning method in detecting ascites and subsequently quantifying its volume in patients with liver cirrhosis and ovarian cancer. Materials and Methods: This retrospective study included contrast-enhanced and non-contrast abdominal-pelvic CT scans of patients with cirrhotic ascites and patients with ovarian cancer from two institutions, National Institutes of Health (NIH) and University of Wisconsin (UofW). The model, trained on The Cancer Genome Atlas Ovarian Cancer dataset (mean age, 60 years +/- 11 [s.d.]; 143 female), was tested on two internal (NIH-LC and NIH-OV) and one external dataset (UofW-LC). Its performance was measured by the Dice coefficient, standard deviations, and 95% confidence intervals, focusing on ascites volume in the peritoneal cavity. Results: On NIH-LC (25 patients; mean age, 59 years +/- 14 [s.d.]; 14 male) and NIH-OV (166 patients; mean age, 65 years +/- 9 [s.d.]; all female), the model achieved Dice scores of 0.855 +/- 0.061 (CI: 0.831-0.878) and 0.826 +/- 0.153 (CI: 0.764-0.887), with median volume estimation errors of 19.6% (IQR: 13.2-29.0) and 5.3% (IQR: 2.4-9.7) respectively. On UofW-LC (124 patients; mean age, 46 years +/- 12 [s.d.]; 73 female), the model had a Dice score of 0.830 +/- 0.107 (CI: 0.798-0.863) and median volume estimation error of 9.7% (IQR: 4.5-15.1). The model showed strong agreement with expert assessments, with r^2 values of 0.79, 0.98, and 0.97 across the test sets. Conclusion: The proposed deep learning method performed well in segmenting and quantifying the volume of ascites in concordance with expert radiologist assessments.