This is a triallelic SNP - note that the sidebar (currently) only shows 3 of the 6 possible genotypes.
CRP[edit]
[PMID 18829218] claims that this SNP does not affect the serum concentration of CRP, while older resources seem to disagree. However, they do report an association between CRP levels and risk of abdominal aortic aneurysm (AAA).
[PMID 16731635] rs3091244 serum CRP level and cardiovascular risk in the NHLBI Family Heart Study.
[PMID 16731635] Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. rs3093059 rs3091244
[PMID 18500540 ] Weaker linkage disequilibrium in this region in African Americans allows the conclusion that basal CRP levels are influenced in an additive manner by the T allele.
Non CRP[edit]
[PMID 18055473] increased risk for the presence of severe hand osteoarthritis with an OR of 2.3 (95% confidence interval (C.I.) 1.2-4.3, P = 0.009)
[PMID 18182444] rs3093061 associated with SLE and functional haplotypes containing rs3091244/rs3093062
Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
0.20 [NR] mg/dl increase
According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.
[PMID 21831326 ] CRP gene variation affects early development of Alzheimer's disease-related plaques
[PMID 15897982 ] Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.
[PMID 16534007] Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.
[PMID 16550411 ] Allelic spectrum of the natural variation in CRP.
[PMID 17161935] Genotyping of triallelic SNPs using TaqMan PCR.
[PMID 19545442 ] Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.
[PMID 19946607 ] Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.
[PMID 20031577 ] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
[PMID 20494378] Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.
[PMID 21496483] Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.
[PMID 21773944] Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.
[PMID 22875596] Association study of CRP gene and ischemic stroke in a Chinese Han population
[PMID 24135623] C-reactive protein polymorphism rs3091244 is associated with abdominal aortic aneurysm
[PMID 32311164 ] Association between C-reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty.