Cisplatin is used to treat cancer. There is some concern that black cohosh might decrease how well cisplatin works for cancer.
Some medications are changed and broken down by the liver. Black cohosh might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Black cohosh might harm the liver. Some medications can also harm the liver. Taking black cohosh along with a medication that can harm the liver might increase the risk of liver damage.
There is concern that black cohosh might harm the liver. Taking black cohosh with atorvastatin might increase the chance of liver damage.
Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates) interacts with BLACK COHOSH
Some medications are moved in and out of cells by pumps. Black cohosh might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Noguchi, M., Nagai, M., Koeda, M., Nakayama, S., Sakurai, N., Takahira, M., and Kusano, G. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull 1998;21(11):1163-1168. View abstract.
Nuntanakorn, P., Jiang, B., Einbond, L. S., Yang, H., Kronenberg, F., Weinstein, I. B., and Kennelly, E. J. Polyphenolic constituents of Actaea racemosa. J Nat Prod 2006;69(3):314-318. View abstract.
Nuntanakorn, P., Jiang, B., Yang, H., Cervantes-Cervantes, M., Kronenberg, F., and Kennelly, E. J. Analysis of polyphenolic compounds and radical scavenging activity of four American Actaea species. Phytochem.Anal. 2007;18(3):219-228. View abstract.
Onorato, J. and Henion, J. D. Evaluation of triterpene glycoside estrogenic activity using LC/MS and immunoaffinity extraction. Anal.Chem 10-1-2001;73(19):4704-4710. View abstract.
Palacio, C., Masri, G., and Mooradian, A. D. Black cohosh for the management of menopausal symptoms : a systematic review of clinical trials. Drugs Aging 2009;26(1):23-36. View abstract.
Petho A. Climacteric complaints are often helped with black cohosh. Ärztliche Praxis 1987;47:1551-1553.
Pierard, S., Coche, J. C., Lanthier, P., Dekoninck, X., Lanthier, N., Rahier, J., and Geubel, A. P. Severe hepatitis associated with the use of black cohosh: a report of two cases and an advice for caution. Eur J Gastroenterol Hepatol. 2009;21(8):941-945. View abstract.