Jin Ho Kwon1121111111
2Department of Biostatistics and Data Innovation, Soonchunhyang University Seoul Hospital, Seoul, Korea
Correspondence Young Shin Cho ,Tel: 02-709-9790, Fax: 02-710-3199, Email: emcys@schmc.ac.kr,
Received: September 25, 2020; Revised: October 27, 2020 Accepted: October 30, 2020. Published online: October 31, 2021.	
This study aimed to compare the effects of high-flow nasal cannula (HFNC) treatment and conventional oxygen therapy (COT) in patients with heart failure (HF) admitted to the emergency department (ED).
This study was a single-center, retrospective, observational study. The subjects were divided into HFNC and COT groups. The characteristics were compared, and vital signs and arterial blood gas (ABG) results were analyzed. In addition, mortality, intubation rate, intensive care unit (ICU) admission, and length of stay (LOS) were analyzed for clinical outcome.
Among 252 patients, 91 and 161 were treated with HFNC and COT. Two groups showed differences in vital signs, ABG results, and pulmonary edema. The HFNC group showed no difference in mortality and LOS, but more intubation and ICU admission were observed (P=0.005, P<0.001). Due to the changes in vital signs and ABG results, the HFNC group reduced blood pressure, heart rate and respiratory rate, improved SpO2, increased pH, and decreased PaCO2.
HFNC therapy effectively improved vital signs and ventilation when administered to relatively unstable patients with HF admitted to the ED.	
Key words: Heart failure; High-flow nasal cannula; Intubation	
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