The oral fluoropyrimidines in cancer chemotherapy
E B Lamont, R L Schilsky
https://web.archive.org/web/20181126104111/http://clincancerres.aacrjournals.org:80/content/clincanres/5/9/2289.full.pdf
A classic example of a rationally developed class of anticancer drugs, the fluoropyrimidines are now the focus of further rational approaches to cancer chemotherapy as they are transformed into oral formulations. Given alone, oral 5-fluorouracil (5-FU) has erratic absorption and nonlinear pharmacokinetics. However, when oral 5-FU is given as a prodrug and/or paired with a dihydropyrimidine dehydrogenase inhibitor, the resultant 5-FU has linear pharmacokinetics that may approximate the less more » ... imate the less myelosuppressive continuous i.v. infusion schedule of 5-FU administration without the use of infusion catheters and pumps. We review the preclinical and clinical experience of several of the oral fluoropyrimidines.
pmid:10499595 fatcat:ih2mbxiv7nccbnzzpkmlocayvq
E B Lamont, R L Schilsky. "The oral fluoropyrimidines in cancer chemotherapy." Clinical Cancer Research 5.9 (1999) 2289-96