Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis: A multicentre study of 1117 cases | Scinapse
Published on Jan 17, 2020in United European gastroenterology journal3.549
Søren Schou Olesen28
(AAU: Aalborg University), Jakob Lykke Poulsen15
(AAU: Aalborg University)+ 16 AuthorsAsbjørn Mohr Drewes78
BackgroundDiabetes mellitus is a common complication of chronic pancreatitis. It is traditionally considered to develop as a consequence of beta cell loss, but there might be additional factors. Re...
References (27)Citations (8)
Oct 1, 2019·Pancreatology3.63
#2Maria Valeryevna LisitskayaH-Index: 3
Last. Scandinavian Baltic Pancreatic ClubH-Index: 4
Abstract Background Pancreatic calcifications is a common finding in patients with chronic pancreatitis (CP), but the underlying pathophysiology is incompletely understood. Past studies for risk factors of calcifications have generally been focused on single parameters or limited by small sample sizes. The aim of this study was to explore several patient and disease characteristics and their associations with pancreatic calcifications in a large cohort of CP patients with diverse aetiological ri... more
#2Asbjørn Mohr DrewesH-Index: 78
Jul 1, 2019·Clinical and translational gastroenterology3.97
#1Mark O. Goodarzi (Cedars-Sinai Medical Center)H-Index: 67
#2Tanvi Nagpal (University of Pittsburgh)H-Index: 1
Introduction:Diabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to
The sentinel acute pancreatitis event hypothesis revisited.
#2Asbjørn Mohr Drewes (AAU: Aalborg University)H-Index: 78
Last. Camilla NøjgaardH-Index: 12
Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.
#1Sarah Jane Schwarzenberg (UMN: University of Minnesota)H-Index: 41
#2Aliye Uc (Boston Children's Hospital)H-Index: 27
Last. Mark E. LoweH-Index: 44
ABSTRACTObjectives:The aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.Me
Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors.
#2Camilla NøjgaardH-Index: 12
OBJECTIVES:Chronic pancreatitis (CP) is characterized by several disease-related complications and multiple etiological risk factors. Past studies of associations between complications and risk factors have mostly been limited to single complications or highly focused on single etiologies. Using an
#2Harika Kandlakunta (Mayo Clinic)H-Index: 2
Background & Aims Of patients with new-onset diabetes (NOD; based on glycemic status) older than 50 years, approximately 1% are diagnosed with pancreatic cancer (PC) within 3 years. We aimed to develop and validate a model to determine risk of PC in patients with NOD. Methods We retrospectively collected data from 4 independent and nonoverlapping cohorts of patients (N = 1,561) with NOD (based on glycemic status; data collected at date of diagnosis and 12 months previously) in the Rochester Epid... more
Fasting Blood Glucose Levels Provide Estimate of Duration and Progression of Pancreatic Cancer Before Diagnosis
Background & Aims It is unclear how long pancreatic ductal adenocarcinomas (PDACs) are present before diagnosis. Patients with PDAC usually develop hyperglycemia and diabetes before the tumor is identified. If early invasive PDACs are associated with hyperglycemia, the duration of hyperglycemia should associate with the time that they have had the tumor. Methods We collected data on patients with PDACs from medical databases in Olmsted County, Minnesota, from 2000 through 2015 and from the Mayo ... more
Apr 23, 2018·The Lancet Diabetes & Endocrinology25.34
#1Anna L. Gloyn (University of Oxford)H-Index: 67
#2Daniel J. Drucker (Lunenfeld-Tanenbaum Research Institute)H-Index: 138
Summary The study of type 2 diabetes has been driven by advances in human genetics, epigenetics, biomarkers, mechanistic studies, and large clinical trials, enabling new insights into disease susceptibility, pathophysiology, progression, and development of complications. Simultaneously, several new drug classes with different mechanisms of action have been introduced over the past two decades, accompanied by data about cardiovascular safety and non-glycaemic outcomes. In this Review, we critical... more
#2David C. Whitcomb (University of Pittsburgh)H-Index: 89
#2Rasmus Hagn-Meincke (AAU: Aalborg University)
Diabetes mellitus is a frequent complication of chronic pancreatitis (CP) and has traditionally been considered to develop as a consequence of pancreatic islet cell loss. However, additional mechan...
Islet cell dysfunction in patients with chronic pancreatitis.
Jul 15, 2020·World Journal of Diabetes3.25
Last. Biju PottakkatH-Index: 5
Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of the pancreas that eventually leads to pancreatic exocrine and endocrine insufficiency. Diabetes in the background of CP is very difficult to manage due to high glycemic variability and concomitant malabsorption. Progressive beta cell loss leading to insulin deficiency is the cardinal mechanism underlying diabetes development in CP. Alpha cell dysfunction leading to deranged glucagon secretion has been describe... more
Pancreatogenic diabetes, acute pancreatitis management, and pancreatic tuberculosis: Appraising the present and setting goals for the future.
#2Georgios I. Papachristou (The Ohio State University Wexner Medical Center)H-Index: 49