"Simvastatin efficiently controlled OCCC proliferation and migration, thus showing potential as a candidate drug for the treatment of OCCC."
Dr. Ingrid Hedenfalk from The Lund University said, "Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer (EOC) accounting for 5–10% of cases diagnosed in Europe and America, while the incidence in Asia is reported to be higher (10–20%)."
Figure 8: Down-regulation of AKT2 decreases tumorigenic capacity (A) Tumorigenic capacity in vivo. 1 × 106 cells were injected into the right flank of female Balb/c mice. Representative photo shows differential volume of tumor at 30 days after cisplatin treatment and tumor burden was assessed after every 3 days in injected animals, for a total of 30 days. Error bars represent mean ± S. D. versus control.
Correspondence to - Ingrid Hedenfalk - Ingrid.Hedenfalk@med.lu.se
Keywords - AKT isoform, CSCs, ABCG2, drug resistance, TNBCs