FORMULATION AND IN-VITRO EVALUATION OF BILAYER TABLETS OF SUMATRIPTAN SUCCINATE
*B. Raja Narender and D. Meghana
The aim of this work was to design mucoadhesive bilayered buccal tablets of Sumatriptan succinate. Sumatriptan succinate is a serotonin 5-HT1 receptor agonist, used in treatment of migraine. It is absorbed rapidly but incompletely when given orally and undergoes first-pass metabolism, resulting in a low absolute bioavailability. Mucoadhesive polymers like xanthun gum and guar gum along with methyl crystalline cellulose were used for the preparation of mucoadhesive bilayered tablets. The optimized formulation followed Non-Fickian release mechanism. The percentage relative bioavailability of Sumatriptan succinate from selected bilayered buccal tablets was found to be 98.7%. Bilayered buccal tablets of Sumatriptan succinate was successfully prepared and evaluated with improved bioavailability.
Keywords: Sumatriptan succinate, bilayered buccal tablets, mucoadhesive polymers.