Topically Used To Relieve Itching, Burning, And Pain From Skin Inflammations, Injected As A Dental Anesthetic, Or As A Local Anesthetic For Minor Surgery
White Crystalline Pharmaceuticals Raw Powder Lidocaine Hydrochloride for Sale
Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.
Lidocaine is an antiarrhythmic agent (affects heart rhythm) as well as a local anesthetic (amide type). It is similar to bupivacaine and procaine. Lidocaine, like other local anesthetics causes a loss of sensation by reducing the flow of sodium in and out nerves to decrease the initiation and transfer of nerve signals. Compared to procaine, lidocaine has a more rapid onset, longer duration of action, and more potent activity. Lidocaine works as an antiarrhythmic by also decreasing conduction of electrical signals in damaged (ischemic) heart tissue. Lidocaine was approved by the FDA in November 1948.
(1) Anaesthesia
Lidocaine alters signal conduction in neurons by blocking the fast voltage-gated Na+ channels in the neuronal cell membrane responsible for signal propagation. With sufficient blockage, the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain, but by stopping them before they begin. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations also affect other modalities of neuron signaling.
(2) Antiarrhythmic
The same principle applies for this drug's actions in the heart. Blocking sodium channels in the conduction system, as well as the muscle cells of the heart, raises the depolarization threshold, making the heart less likely to initiate or conduct early action potentials that may cause an arrhythmia.
Function 1. Local anesthetic.
Identification BCDE Conforms
Comply with the requirement
Chloride Not more than 0. 0035% 0.00%
Impurity Not more than 0.01% Conforms
(26-dimethylaniline content)