MICROBIOME - Biom Pharmaceuticals
MICROBIOMEBindu2021-02-20T05:31:23+00:00	
THE REAL STORY OF OUR GENETIC COMPLEXITY
Two parallel genomes: MICROBIOME vs GENOME
Two parallel genomes:
MICROBIOME vs GENOME
Collection of all commensal microbial genes in body
TOTAL MICROBIAL CELLS: 40000000
TOTAL GENES: 3000000
Inherited from mother environment,other sources
High variability within and between individuals
Dysbiosis causes desease conditions
Microbiome diversity:monitored easily
High degree of pasticity or adaptability
Can be modulated by targeted interventions
Collection of all human genes in body
Total human celles: 40000000
Total genes:23000
Inherited from both parents
Stable limited degree of plasticity
Genome mutations causes desease conditions
Diversity:limited
Gene modulations:risky
Health & Well-being/Disease prevention/Longevity
The gut microbiota has a crucial role in metabolic health, but researchers are only just determining the mechanisms underpinning this effect. Studies have found that specific class of bacteria that degrades mucin in the gut lining and can have beneficial effects on metabolic disorders, has a key role in systemic glucose metabolism. These classes of bacteria modulates glucose metabolism by altering gene expression of certain key biomolecules in ileum.
Everyone’s microbiome appears to be unique and is readily modified by diet, its multiple microorganisms seem to have overlapping roles and applied microbiome interventions could revolutionize the way we think about gut bacteria in relation to weight loss, immunity, disease and the creation of essential nutrients.Changes in microbiome composition and diversity are associated with the development of metabolic diseases and microbiome is considered as the next big platform for diagnostic and drug discovery for treating autoimmune, metabolic and infectious diseases. There are a number of benefits in microbiome-based approach in controlling or treating metabolic diseases unlike human genome sequence-based interventions. Further, emerging scientific information shows the importance of microbiome in determining your healthy life-span.