Sampling considerations for a potential Zika virus urosurvey in New York City
By Thompson, C. N. ; Lee, C. T. ; Immerwahr, S. ; ...
Title : Sampling considerations for a potential Zika virus urosurvey in New York City Personal Author(s) : Thompson, C. N.;Lee, C. T.;Immerwahr, S.;Resnick, S.;Culp, G.;Greene, S. K.; Published Date : August 08 2018;10-2018; Source : Epidemiol Infect. 146(13):1628-1634 URL : https://stacks.cdc.gov/view/cdc/84109
Thompson, C. N. ; Lee, C. T. ; Immerwahr, S. ; Resnick, S. ; Culp, G. ; ... More +
Thompson, C. N. ; Lee, C. T. ; Immerwahr, S. ; Resnick, S. ; Culp, G. ; Greene, S. K. ; Less -
In 2016, imported Zika virus (ZIKV) infections and the presence of a potentially competent mosquito vector (Aedes albopictus) implied that ZIKV transmission in New York City (NYC) was possible. The NYC Department of Health and Mental Hygiene developed contingency plans for a urosurvey to rule out ongoing local transmission as quickly as possible if a locally acquired case of confirmed ZIKV infection was suspected. We identified tools to (1) rapidly estimate the population living in any given 150-m radius (i.e. within the typical flight distance of an Aedes mosquito) and (2) calculate the sample size needed to test and rule out the further local transmission. As we expected near-zero ZIKV prevalence, methods relying on the normal approximation to the binomial distribution were inappropriate. Instead, we assumed a hypergeometric distribution, 10 missed cases at maximum, a urine assay sensitivity of 92.6% and 100% specificity. Three suspected example risk areas were evaluated with estimated population sizes of 479-4,453, corresponding to a minimum of 133-1244 urine samples. This planning exercise improved our capacity for ruling out local transmission of an emerging infection in a dense, urban environment where all residents in a suspected risk area cannot be feasibly sampled.	
Urosurvey
urn:sha256:8f57f9b4820958e50db12c6ae2a7f0fe2b05663a7857d91796087a8e3c38a3c2	
Notes: This tool summarizes general CDC guidance for the following scenarios. Please consult CDC or your state or local health department for case-spe...	