From natural products to biological tools*
Peter Wipf, Thomas H. Graham, and Jingbo Xiao
Department of Chemistry and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Abstract: The development of a total synthetic approach for the antimitotic disorazole C1 and the design of a peptide isostere linked to the reactive oxygen scavenger 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) demonstrate established as well as novel strategies for mining the therapeutic potential of natural products.
Keywords: natural products; disorazole; gramicidin S; antimitotic; mitochondria.