Frequent question: How do cancer cells avoid cell death? - Myths about oncology
Frequent question: How do cancer cells avoid cell death?
Do cancer cells undergo cell death?
What is the molecular basis of cancerous cell to evade apoptosis?
Is apoptosis good for cancer?
What encourages apoptosis?
Regulation of apoptosis in normal and cancer cells
Cancers cells are largely dependent upon pro-survival proteins of the BCL-2 family for evasion of apoptosis. Recent advances in understanding regulation of apoptosis have shown that BCL-2 proteins are under tight metabolic control. Several BH3 mimetics have been developed to target the primed state of cancer cells.
Targeting apoptosis is also effective for all types of cancer, as apoptosis evasion is a hallmark of cancer and is nonspecific to the cause or type of the cancer. There are many anticancer drugs that target various stages in both the intrinsic and extrinsic pathways [7,8,9].
Phenol compounds of this plant show cytotoxic activity through apoptosis in cancer cells. Resveratrol is a phytoalexin found in grapes. It was shown that resveratrol causes apoptosis in HL60 cells and T47D (breast carcinoma cells). It induces apoptosis through CD95 signaling–dependent apoptosis in HL60 and T47D cells.