Sensors | Special Issue : Biosensor and Bioelectronics for Biomedical Applications
Biosensor and Bioelectronics for Biomedical Applications
Special Issue "Biosensor and Bioelectronics for Biomedical Applications"
Dr. Eileen Yu
Interests: bioelectrochemical systems; resource recovery; environmental engineering; electrochemical engineering and materials
Special Issue in Energies: Microbial Electrochemical Systems
Dr. Samet Şahin
Department of Bioengineering, Bilecik Şeyh Edebali University, 11230 Merkez/BİLECİK, Turkey
Interests: enzymatic biofuel cell; biosensors; bioelectronics; modified electrodes
Biosensors have become more and more important due to their essential role in the detection of various physiological markers for biomedical research. They can be highly specific, able to work in different physical parameters depending on the design, and reusable. These unique advantages of biosensors have attracted many researchers to develop different innovative strategies, such as point-of-care detection and wearable and implantable systems. The emerging field of bioelectronics, on the other hand, explores the relationship between biology and electronics for applications such as powering microelectronic systems, information processing, and storage using biological fuel cells, bionics, and biomaterials.
In this context, biosensor and bioelectronic systems play a crucial role in the diagnosis and monitoring of various diseases, and healthcare applications. There are challenges, particularly specificity, sensitivity, selectivity, and stability of the devices in need of advanced approaches and technologies. For final products, simplicity, adaptability, and integration are also critical issues.
This Special Issue is devoted to exploring new approaches, solutions, and applications in biosensor and bioelectronics for biomedical applications. We would like to invite you to contribute with original research papers, as well as comprehensive reviews (subject to editorial pre-approval), focusing on biosensing and bioelectronic solutions in biomedical applications. Contributions to address certain issues in biomedical applications might include but not limited to following topics:
Optic based biosensors
Point-of-care biosensing
Wearable biosensor and bioelectronics
Lab-on-chip bioelectronics
Self-powered bioelectronics
Biomaterials for biosensor and bioelectronics
DNA aptamers are short nucleotide oligomers selected to bind a target ligand with affinity and specificity rivaling that of antibodies. These remarkable features recommend aptamers as candidates for analytical and therapeutic applications that traditionally use antibodies as biorecognition elements. Numerous traditional and emerging [...] Read more.
DNA aptamers are short nucleotide oligomers selected to bind a target ligand with affinity and specificity rivaling that of antibodies. These remarkable features recommend aptamers as candidates for analytical and therapeutic applications that traditionally use antibodies as biorecognition elements. Numerous traditional and emerging analytical techniques have been proposed and successfully implemented to utilize aptamers for sensing purposes. In this work, we exploited the analytical capabilities offered by the kinetic exclusion assay technology to measure the affinity of fluorescent aptamers for their thrombin target and quantify the concentration of analyte in solution. Standard binding curves constructed by using equilibrated mixtures of aptamers titrated with thrombin were fitted with a 1:1 binding model and provided an effective Kd of the binding in the sub-nanomolar range. However, our experimental results suggest that this simple model does not satisfactorily describe the binding process; therefore, the possibility that the aptamer is composed of a mixture of two or more distinct Kd populations is discussed. The same standard curves, together with a four-parameter logistic equation, were used to determine “unknown” concentrations of thrombin in mock samples. The ability to identify and characterize complex binding stoichiometry, together with the determination of target analyte concentrations in the pM–nM range, supports the adoption of this technology for kinetics, equilibrium, and analytical purposes by employing aptamers as biorecognition elements. Full article