Challenges and opportunities for oral pre-exposure prophylaxis in the prevention of HIV infection: where are we in Europe? - Inserm
Jean-Michel Molina 1, 2, * Claire Pintado 2 Caroline Gatey 2 Diane Ponscarme 2 Pierre Charbonneau 2 Benedicte Loze 2 Willy Rozenbaum 2 Constance Delaugerre 1, 3
Claire Pintado 2 AuthorId : 942404
Caroline Gatey 2 AuthorId : 942405
Diane Ponscarme 2 AuthorId : 942406
Pierre Charbonneau 2 AuthorId : 942407
Benedicte Loze 2 AuthorId : 942408
Willy Rozenbaum 2 AuthorId : 942409
3 Laboratoire de virologie (Paris - France) StructId : 236059
Abstract : Following US Food and Drugs Administration approval in July 2012 of daily oral tenofovir and emtricitabine for pre-exposure prophylaxis (PrEP) to prevent HIV infection in high-risk individuals in the USA, there has been much controversy about the implementation of this PrEP regimen in other countries throughout the world, and in Europe in particular. In this review, we focus on the challenges and opportunities of a daily oral PrEP regimen to curb the rising incidence of HIV infection in high-risk groups, and particularly in men who have sex with men. A number of issues would need to be addressed before PrEP could be implemented, including assessing the real effectiveness and cost-effectiveness of daily PrEP, the sustainability of daily adherence, the risk of selecting resistance, the long-term safety, and the risk of change in sexual behavior that might offset the benefit of PrEP. Alternatives to a daily oral PrEP regimen are being explored.
Keywords : HIV Tenofovir Emtricitabine Men who have sex with men Intermittent PrEP Adherence
Jean-Michel Molina, Claire Pintado, Caroline Gatey, Diane Ponscarme, Pierre Charbonneau, et al.. Challenges and opportunities for oral pre-exposure prophylaxis in the prevention of HIV infection: where are we in Europe?. BMC Medicine, BioMed Central, 2013, 11 (1), pp.186. ⟨10.1186/1741-7015-11-186⟩. ⟨inserm-00903749⟩