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Hyperoxaluria is a condition in which there are high levels of oxalate in the urine. Oxalate is found naturally in foods like spinach, nuts, chocolate, and tea. It is also a normal byproduct of metabolism. Normally, the excess oxalate is removed by the kidneys through your urine. However, when there is too much oxalate in your urine, it can form crystals that may cause inflammation or grow into kidney stones.
Some people’s livers make too much oxalate due to a genetic condition called primary hyperoxaluria. Another kind of hyperoxaluria occurs in people with an underlying malabsorptive gastrointestinal (GI) condition that leads to absorption of too much oxalate from foods—this is called enteric hyperoxaluria. People can develop enteric hyperoxaluria due to complications from gastric bypass surgeries or surgery to remove part of the intestine. GI conditions like Crohn’s disease, ulcerative colitis, and disorders of the pancreas due to cystic fibrosis or pancreatitis can also cause enteric hyperoxaluria.
How Allena can help
Currently there are no approved treatments for enteric hyperoxaluria. Our investigational product reloxaliase is an oral enzyme that breaks down oxalate within the GI tract and helps reduce the burden on the kidney. In a clinical trial, reloxaliase was well tolerated with no serious adverse events.
If you suffer from frequent kidney stones and are looking for potential new ways to prevent them from returning, you may want to consider participating in the UriROX-2 Study.
For additional information about hyperoxaluria,
please visit the Oxalosis & Hyperoxaluria Foundation.
For more information about Hyperuricemia and Gout, visit MedlinePlus.
Hyperuricemia is an excess of urate in the blood. The body produces urate when it breaks down purines—substances that are found naturally in the body. Purines are also found in foods such as red meat, shellfish, and alcoholic beverages. Fructose, a “simple sugar” found in honey, fruit, and sweetened beverages, increases purine metabolism, which can also raise blood urate levels.
Elevated urate in the blood can lead to kidney stones and the formation of needlelike crystals in the joints. These crystals can lead to “gouty flares” of the joints and can result in kidney stones.
Our product ALLN-346 is a first-in-class formulation of an enzyme that breaks down urate in the intestinal tract. It has the potential to reduce the burden on the kidney and lower the risk of gouty arthritis, gout attacks, and kidney stones.