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Mellaril – general information
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Mellaril - General Information
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Mellaril has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618)
Mellaril is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Mellaril has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Mellaril Indication: For the treatment of schizophrenia and generalized anxiety disorder.
Mechanism Of Action: Mellaril blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Dosage Forms of Mellaril: Tablet Oral