CAS 51-28-5 4- Dinitrophenol Yellow Weight Loss Powder Reduced Fat DNP bodybuilding
2 , 4-Dinitrophenol
Other name:DNP
Synonyms:X32;EK,102;2,4-DNP;Dinitra;Dinofan;Fenoxyl;nsc1532;Aldifen;NSC 1532;Maroxol-50
Appearance: Yellow powder .
Application:Reduced fat
DNP was used extensively in diet pills from 1933 to 1938 after Cutting and Tainter at Stanford University made their first report on the drug's ability to greatly increase metabolic rate. After only its first year on the market Tainter estimated that probably at least 100,000 persons had been treated with DNP in the United States, in addition to many others abroad. DNP acts as a protonophore, allowing protons to leak across the inner
mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient. In effect, part of the energy that is normally produced from cellular respiration is wasted as heat. The inefficiency is proportional to the dose of DNP that is taken. As the dose increases and energy production is made more inefficient, metabolic rate increases (and more fat is burned) in order to compensate for the inefficiency and meet energy demands. DNP is probably the best known agent for uncoupling oxidative phosphorylation. The production or "phosphorylation" of ATP by ATP synthase gets disconnected or "uncoupled" from oxidation.
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