Beyond that research, the September 3, 2010, issue of the journal Cell reports the discovery by researchers at the University of California, San Diego School of Medicine of the mechanism used by omega-3 fatty acids in lowering insulin resistance and chronic inflammation. Using cell cultures in mice, Dr. Jerrold Olefsky, a professor of medicine and associate dean of scientific affairs, and colleagues found that exposure to omega-3 fatty acids activates the cellular receptor known as GPR120, which is located on macrophages in mature fat cells and, when activated, prevents the macrophages from causing inflammation. “It’s just an incredibly potent effect,” stated Dr. Olefsky. “Omega-3s are very potent activators of GPR120 on macrophages—more potent than any other anti-inflammatory we’ve ever seen…. Our work shows how fish oils safely do this and suggests a possible way to treating the serious problems of inflammation in obesity and in conditions such as diabetes, cancer, and cardiovascular disease through simple dietary supplementation.”
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