DNA isa polymer of nucleotides whicharelinked to each other by 3′-5’phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?
A. Replace purine with pyrimidines.
B. Remove/Replace 3′ OH group in deoxyribose.
C. Remove/Replace 2′ OH group with some other group in deoxyribose.
D. Both ‘b’ and ‘c’.
Answer:B
DNA isa polymer of nucleotides whicharelinked to each other by 3′-5’phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?
A. Replace purine with pyrimidines. B. Remove/Replace 3′ OH group in deoxyribose. C. Remove/Replace 2′ OH group with some other group in deoxyribose. D. Both ‘b’ and ‘c’.